Digital Commons Network^™

Personal Environmental Information: The Promise And Perils Of The Emerging Capacity To Identify Individual Environmental Harms, Katrina Fischer Kuh

Elisabeth Haub School of Law Faculty Publications

This Article begins from the premise that successful regulation of environmentally significant individual behaviors could achieve meaningful environmental benefits and argues that (1) technology is increasingly making information about individual environmental behaviors and associated harms more accessible; (2) better information about environmentally significant individual behaviors could substantially enhance fledgling efforts to regulate those behaviors; and (3) use of technology-enabled personal environmental information in support of regulation will require the resolution of myriad privacy concerns. The Article seeks to generate and inform a discussion about the appropriate balance between access to personal environmental information and privacy by identifying how regulation can …

Rethinking The New Public Health, Lindsay Wiley

Scholarly Articles in Law Reviews & Journals

This Article contributes to an emerging theoretical debate over the legitimate scope of public health law by linking it to a particular doctrinal debate in public nuisance law. State and local governments have been largely stymied in their efforts to use public nuisance litigation against harmful industries to vindicate collectively-held, common law rights to non-interference with public health and safety. The ways in which this litigation has failed are instructive for a broader movement in public health that is only just beginning to take shape. In response to evolving scientific understanding about the determinants of health, public health advocates are …

Blue Light (470 Nm) Effectively Inhibits Bacterial And Fungal Growth, A.J. De Lucca, C. Carter-Wientjes, K.A. Williams, D. Bhatnagar

United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications

Blue light (470 nm) LED antimicrobial properties were studied alone against bacteria and with or without the food grade photosensitizer, erythrosine (ERY) against filamentous fungi. Leuconostoc mesenteroides (LM), Bacillus atrophaeus (BA) or Pseudomonas aeruginosa (PA) aliquots were exposed on nutrient agar plates to Array 1 (AR1, 0•2 mW cm^-2) or Array 2 (AR2, 80 mW cm^-2), which emitted impure or pure blue light (0–300 J cm-²), respectively. Inoculated control (room light only) plates were incubated (48 h) and colonies enumerated. The antifungal properties of blue light combined with ERY (11•4 and 22•8 µmol l …

Infection Control And Health Care Associated Infection (Hcai) In The Nursing Home: A Study To Determine The Impact Of An Educational Video And Pamphlet About Infection Control On Knowledge And Perception Of Hand Hygiene In Certified Nurse Assistants, Kathe Hypes

Electronic Theses and Dissertations

The impact of an education program on perception, knowledge, and infection rate was evaluated in this study. The educational intervention consisted of a video on infection control and a World Health Organization (WHO) pamphlet for hand hygiene. The study was conducted in one nursing home in the Southeastern United States. The survey sample consisted of 66 certified nurse assistants (CNAs). A pre- and post-intervention design was employed using the WHO’s Hand Hygiene Knowledge Questionnaire and the WHO Perception Survey. Friedman’s test and central tendencies showed no statistical relationship between the educational intervention and the overall knowledge scores of the sample. …

Arctic Justice: Addressing Persistent Organic Pollutants, Elizabeth Burleson

Elisabeth Haub School of Law Faculty Publications

This article recommends enhanced governance of persistent organic pollutants through incentives to develop environmentally sound, climate friendly technologies as well as caution in developing the Arctic. It highlights the toxicity challenges presented by POPs to Arctic people and ecosystems.

Brucellosis Transmission Between Wildlife And Livestock In The Greater Yellowstone Ecosystem: Inferences From Dna Genotyping, Michael Patrick O'Brien

Graduate Student Theses, Dissertations, & Professional Papers

Brucellosis transmission between wildlife species and cattle in the greater Yellowstone ecosystem has been difficult to assess because the causative agent Brucella abortus bacteria is extremely difficult to isolate for DNA genotyping. We examined transmission of B. abortus between bison, elk, and cattle using nine variable-number tandem repeat (VNTR) markers on DNA from 98 isolates of B. abortus recovered from elk, bison, and cattle. All specimens were from geographically distinct populations in Idaho, Montana, and Wyoming. A haplotype network consisting of 54 individual haplogroups was generated from these isolates using Network v4.61. Network assessments of genetic relatedness among Brucella isolates …

Protegrin-1 Inhibits Dengue Ns2b-Ns3 Serine Protease And Viral Replication In Mk2 Cells, H.A. Rothan, A.Y. Abdulrahman, P.G. Sasikumer, S. Othman, N. Abd Rahman, R. Yusof

Research Publications (2011 to 2015)

Dengue diseases have an economic as well as social burden worldwide. In this study, the antiviral activity of protegrin-1 (PG-1, RGGRLCYCRRRFCVCVGR) peptide towards dengue NS2B-NS3pro and viral replication in Rhesus monkey kidney (MK2) cells was investigated. The peptide PG-1 was synthesized by solid-phase peptide synthesis, and disulphide bonds formation followed by peptide purification was confirmed by LC-MS and RPHPLC. Dengue NS2B-NS3pro was produced as a single-chain recombinant protein in E. coli. The NS2B-NS3pro assay was carried out by measuring the florescence emission of catalyzed substrate. Real-time PCR was used to evaluate the inhibition potential of PG-1 towards dengue serotype-2 (DENV-2) …

Evaluation Of Antibodies Against Glycoprotein D (Gd) And Glycoprotein G (Gg) In Hsv-1 Infected Individuals' Serum Samples, Z. Meshkat, M.N. Roostaee, M. Soleimanjahi, K. Zandi

Research Publications (2011 to 2015)

Background and Objectives: Glycoproteins D (gD) and G (gG) of herpes simplex virus type 1 (HSV-1) are virus envelope glycoproteins that are able to induce HSV-1 antibody production in infected persons. Therefore, those proteins could be in interest to develop the serodiagnostic test(s) for HSV antibody detection. The aim of present study was the comparison of anti-gD and anti-gG antibodies in HSV-1 infected individuals serum samples. Materials and Methods: In this study, recombinant gD and gG were prepared and used for western blot test to detect the antibodies against HSV-1. Results: Our data showed the total gD antibody titer was …

Language Impairment In Children Perinatally Infected With Hiv Compared To Children Who Were Hiv-Exposed And Uninfected, Mabel L. Rice, L. Buchanan, George K. Siberry, Kathleen M. Malee, Bret Zeldow, Toni Frederick, Murli U. Purswani, Howard J. Hoffman, Patricia A. Sirois, Renee Smith, Peter Torre Iii, Susannah M. Allison, Paige L. Williams

Pharmacy Practice and Clinical Research Faculty Publications

Objective - To investigate risk for language impairment in children perinatally infected or exposed to HIV.

Methods - We evaluated the prevalence of language impairment (LI) in 7–16 year old children with perinatal HIV infection (HIV+) compared to children HIV-exposed and uninfected (HEU), using a comprehensive standardized language test (CELF-4). LI was classified as primary LI (Pri-LI) (monolingual English exposure and no cognitive or hearing impairment), concurrent LI (Con-LI) (cognitive or hearing impairment), or no LI. Associations of demographic, caregiver, HIV disease and antiretroviral treatment (ART) factors with LI category were evaluated using univariate and multivariable logistic regression models.

Results …

Plants Of The Western United States: Expanding The Collection And Biological Testing Of Extracts, Fernando N. Galvan

Undergraduate Honors Theses

The goal of this research was to find compounds with the potential for use as medicines. Many microorganisms use a mechanism known as active efflux to move antibiotics out of cells. As a result, the effectiveness of antibiotics may be partially or completely reduced allowing the pathogen to survive. A major theme of this research was to look for compounds in plants that inhibit active efflux processes and that are related to multi-drug resistance. After the diffusion of an antibiotic into a bacterial cell, an efflux pump inhibitor may prevent the antibiotic from being expelled from the organism, leading to …

Toward The Synthesis Of 5-Benzyl-3-Hydroxy-1,3-Azaborines As Potential Inhibitors Of Hiv-1 Protease, Julia Jennings

Undergraduate Honors Theses

Currently, approximately 33.3 million people are living with HIV/AIDS worldwide and each year an additional 2.1 million people become infected. The goal of this research is to develop 1,3-azaborines that could potentially inhibit HIV-1 protease. HIV-1 protease is an enzyme involved in the protein processing step of the replication cycle. By inhibiting HIV-1 protease, the drug would slow the progression of HIV into AIDS. The target compounds are expected to have both competitive and associative inhibition and may inhibit mutated HIV viruses as well. To synthesize these compounds, boronic acids were coupled with a chiral directing/protecting group. A homologation was …

Aleuria Aurantia Lectin (Aal)-Reactive Immunoglobulin G Rapidly Appears In Sera Of Animals Following Antigen Exposure., Songming Chen, Chen Lu, Hongbo Gu, Anand Mehta, Jianwei Li, Patrick B Romano, David Horn, D Craig Hooper, Carthene R Bazemore-Walker, Timothy Block

Department of Cancer Biology Faculty Papers

We have discovered an Aleuria Aurantia Lectin (AAL)-reactive immunoglobulin G (IgG) that naturally occurs in the circulation of rabbits and mice, following immune responses induced by various foreign antigens. AAL can specifically bind to fucose moieties on glycoproteins. However, most serum IgGs are poorly bound by AAL unless they are denatured or treated with glycosidase. In this study, using an immunogen-independent AAL-antibody microarray assay that we developed, we detected AAL-reactive IgG in the sera of all animals that had been immunized 1-2 weeks previously with various immunogens with and without adjuvants and developed immunogen-specific responses. All of these animals subsequently …

Aleuria Aurantia Lectin (Aal)-Reactive Immunoglobulin G Rapidly Appears In Sera Of Animals Following Antigen Exposure., Songming Chen, Chen Lu, Hongbo Gu, Anand Mehta, Jianwei Li, Patrick B Romano, David Horn, D Craig Hooper, Carthene R Bazemore-Walker, Timothy Block

Department of Cancer Biology Faculty Papers

We have discovered an Aleuria Aurantia Lectin (AAL)-reactive immunoglobulin G (IgG) that naturally occurs in the circulation of rabbits and mice, following immune responses induced by various foreign antigens. AAL can specifically bind to fucose moieties on glycoproteins. However, most serum IgGs are poorly bound by AAL unless they are denatured or treated with glycosidase. In this study, using an immunogen-independent AAL-antibody microarray assay that we developed, we detected AAL-reactive IgG in the sera of all animals that had been immunized 1-2 weeks previously with various immunogens with and without adjuvants and developed immunogen-specific responses. All of these animals subsequently …

Symptom Intrusiveness, Chronic Conditions And Health-Related Quality Of Life: Development Of Conceptual And Measurement Models, Jill Marie Monfre

MUSC Theses and Dissertations

Background: The number of patients in the United States living with chronic conditions is increasing as patients are surviving conditions that were previously fatal. This increase in survival has resulted in a shift in the disease burden in the United States from infectious to chronic diseases. Many patients with chronic conditions experience associated symptoms that impact their health-related quality of life more significantly than those without associated symptoms. To enable patients to achieve what they determine to be an acceptable state of wellbeing, health care providers must first be aware of the factors and the relationships among the factors that …

Rate-Based Robust Adaptive Performance Tracking Control Of Network Flows, Xiaoyan Mei

Dissertations

Network flow control methods have been studied for years to ensure the efficient usage of network resources. By adopting a representation reminiscent of the sliding surface representation, this work explores a highly adaptive network flow control strategy. The rate-based network flow control scheme is investigated through a novel model description in the matrix notation, and guaranteed to be stable under mild assumptions. The control law has a simple form but the proof of robust stability is quite involved via the Lyapunov theory. Simulations demonstrated that the developed adaptive algorithms are robust and effective in maintaining good link price and backlog …

Childhood Unintentional Injuries: Need For A Community-Based Home Injury Risk Assessments In Pakistan., Adnan A. Hyder, Aruna Chandran, Uzma R. Khan, Nukhba Zia, Cheng-Ming Huang, Sarah Stewart De Ramirez, Junaid Razzak

Department of Emergency Medicine

Background. A substantial proportion of the annual 875,000 childhood unintentional injury deaths occur in the home. Very few printed tools are available in South Asia for disseminating home injury prevention information. Methods. Three tools were planned: an injury hazard assessment tool appropriate for a developing country setting, an educational pamphlet highlighting strategies for reducing home injury hazards, and an in-home safety tutorial program to be delivered by a trained community health worker. Results. The three tools were successfully developed. Two intervention neighborhoods in Karachi, Pakistan, were mapped. The tools were pretested in this local setting and are now ready for …

Nitric Oxide Metabolites As Biomarkers For Influenza-Like Acute Respiratory Infections Presenting To The Emergency Room, Asad Mian, Federico R Laham, Andrea T Cruz, Harsha Garg, Charles G Macias, A. Chantal Caviness, Pedro A Piedra

Department of Emergency Medicine

Aims: Nitric oxide (NO) is increased in the respiratory tract in pulmonary infections. The aim was to determine whether nasal wash NO metabolites could serve as biomarkers of viral pathogen and disease severity in children with influenza-like illness (ILI) presenting to the emergency department (ED) during the 2009 influenza A H1N1 pandemic.
Methods: Children ≤18 years old presenting to the ED with ILI were eligible. Nasal wash specimens were tested for NO metabolites, nitrate and nitrite, by HPLC and for respiratory viruses by real-time PCR.
Results: Eighty-nine patients with ILI were prospectively enrolled during Oct-Dec, 2009. In the …

The Brilliant Career Of Section 7 Of The Charter, Peter W. Hogg

The Supreme Court Law Review: Osgoode’s Annual Constitutional Cases Conference

Section 7 of the Charter of Rights was not intended by the framers to be a provision that authorized extensive judicial review of legislation. The protection of property was deliberately not included in its text in order to reduce its scope — and the potential for judicial review. and the phrase “the principles of fundamental justice” was intended to cover only procedural due process. Contrary to expectations in 1982, over the succeeding 30 years the Supreme Court of Canada has given an expansive interpretation to section 7 and used it to strike down a variety of laws, including the criminalization …

Inmates Of New York State With Hiv V. New York, Legal Aid Society Of New York

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Youth - A Scare Commodity Within An Ageing World, Sarah Harper

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Health Care Reform: The Way Forward, Paul Ryan

Notre Dame Journal of Law, Ethics & Public Policy

No abstract provided.

Human Trafficking And Health Care Professionals: Assessment Of Medical And Nursing Education Programs' Curricula On Recognizing And Helping Victims Of Human Trafficking, Nurlanbek Sharshenkulov

Electronic Theses and Dissertations

This study was conducted with the focus on medical and nursing education programs in the U.S. in order to learn if they include training for their students on dealing with victims of human trafficking. In order to address this goal, the survey among professors and instructors of 650 randomly selected medical and nursing education programs was conducted, where they were asked if their programs' curricula include training on recognizing victims of trafficking, as well as providing them with health care services and assistance to escape from their traffickers. The analysis of 116 received responses revealed that the majority of medical …

Box Traps For Feral Swine Capture: A Comparison Of Gate Styles In Texas, David B. Long, Tyler A. Campbell

United States Department of Agriculture Wildlife Services: Staff Publications

Many different types of traps have been developed to increase feral swine (Sus scrofa) capture efficiency. Though not previously compared, gate styles may influence capture success. Our objectives were to report feral swine capture data from 31 trapping campaigns conducted in 17 counties from 2005 to 2011 in Texas, USA, compare capture rates by demographic category between side-swing and rooter gates, and evaluate influences of moisture, using the Palmer Drought Severity Index (PDSI), on juvenile capture rates. We trapped feral swine during all months of the year. Our trap configurations were identical with the exception of gate style. Traps had …

Identification And Analysis Of The First 2009 Pandemic H1n1 Influenza Virus From U.S. Feral Swine, A. Clavijo, Amir Nikooienejad, M. S. Esfahani, Richard P. Metz, Scott Schwartz, Esmaeli Atashpaz-Gargari, Thomas J. Deliberto, M. W. Lutman, Kerri Pedersen, L. R. Bazan, L. G. Koster, M. Jenkins-Moore, S. L. Swenson, M. Zhang, T. Beckham, Charles D. Johnson, Mohammad Bounpheng

United States Department of Agriculture Wildlife Services: Staff Publications

The first case of pandemic H1N1 influenza (pH1N1) virus in feral swine in the United States was identified in Texas through the United States Department of Agriculture (USDA) Wildlife Services’ surveillance program. Two samples were identified as pandemic influenza by reverse transcriptase quantitative PCR (RT-qPCR). Full-genome Sanger sequencing of all eight influenza segments was performed. In addition, Illumina deep sequencing of the original diagnostic samples and their respective virus isolation cultures were performed to assess the feasibility of using an unbiased whole-genome linear target amplification method and multiple sample sequencing in a single Illumina GAIIx lane. Identical sequences were obtained …

Quantitative Pcr Estimates Angiostrongylus Cantonensis (Rat Lungworm) Infection Levels In Semi-Slugs (Parmarion Martensi), Susan I. Jarvi, Margaret E.M. Farias, Kay Howe, Steven Jacquier, Robert Hollingsworth, William Pitt

United States Department of Agriculture Wildlife Services: Staff Publications

The life cycle of the nematode Angiostrongylus cantonensis involves rats as the definitive host and slugs and snails as intermediate hosts. Humans can become infected upon ingestion of intermediate or paratenic (passive carrier) hosts containing stage L3 A. cantonensis larvae. Here, we report a quantitative PCR (qPCR) assay that provides a reliable, relative measure of parasite load in intermediate hosts. Quantification of the levels of infection of intermediate hosts is critical for determining A. cantonensis intensity on the Island of Hawaii. The identification of high intensity infection ‘hotspots’ will allow for more effective targeted rat and slug control measures. qPCR …

Exploring Conformational Variability Of An Rna Domain In The Ribosome: From Structure And Function To Potential Antibiotic Targeting, Yogo Sakakibara

Wayne State University Dissertations

RNA in nature is modified at many specific sites to order to gain extra functions or to expand the genetic code. One of such RNAs is ribosomal RNA (rRNA), which contains several modified bases, particularly around the functionally significant sites. We have focused on understanding the influences of modified base on RNA structure and function by employing helix 69 (H69), which is a good region to evaluate the roles of modified bases since it contains three pseudouridines in the loop region and exists at the core of the ribosome.

Previous model studies using small hairpin H69 showed the conformational differences …

In Vivo Display: A Selection And Its Derivatives For Antimicrobial Peptide Lead Identification, Wesley David Colangelo

Wayne State University Dissertations

The rise of antibiotic resistance necessitates new approaches for the isolation of new antimicrobials with novel inhibitory mechanisms, bypassing the development of rapid resistance by modification of pre-existing resistance mechanisms. In response, we have developed a series of systems for the rapid isolation and identification of peptides that inhibit the growth of Escherichia coli and other bacteria, termed in vivo display (IVD).

IVD harnesses the cellular processes of E. coli for the expression of a library of random peptides at the terminus of a display protein. A library of 12-amino acid random peptide sequences was added to either the C- …

"Still Here, Trying To Find My Way": Understanding The Experiences Of Hiv Disruption And Reorganization Among Older African Americans In Detroit, Andrea Nevedal

Wayne State University Dissertations

Adults aged fifty and older are the fastest growing age group with HIV/AIDS. Research on older adults with HIV has focused primarily on health status and physiological changes that occur as people age with HIV. However, little is known about the socio-cultural consequences that occur when older adults are diagnosed with HIV and as they age with HIV. Drawing from an anthropological approach to the life course and Becker's (1997) framework of life disruption, this dissertation research explored to what extent people experienced disruption from living with HIV and reorganized their lives after experiencing disruption.

The specific aims included identifying …

Uab Magazine - Fall 2012, University Of Alabama At Birmingham

UAB Magazine

No abstract provided.

Unm Health Sciences Center Data Book 2011-12, University Of New Mexico - Health Sciences Center

Health Sciences Center Databook (1990-ongoing)

No abstract provided.