Digital Commons Network^™

Oxidative Stress And Down Syndrome: A Route Toward Alzheimer-Like Dementia, Marzia Perluigi, D. Allan Butterfield

Chemistry Faculty Publications

Down syndrome (DS) is one of the most frequent genetic abnormalities characterized by multiple pathological phenotypes. Indeed, currently life expectancy and quality of life for DS patients have improved, although with increasing age pathological dysfunctions are exacerbated and intellectual disability may lead to the development of Alzheimer's type dementia (AD). The neuropathology of DS is complex and includes the development of AD by middle age, altered free radical metabolism, and impaired mitochondrial function, both of which contribute to neuronal degeneration. Understanding the molecular basis that drives the development of AD is an intense field of research. Our laboratories are interested …

Encouraging Further Innovation: Ariad V. Eli Lilly And The Written Description Requirement, Joseph Jakas

Seton Hall Law Review

No abstract provided.

Assessing The Therapeutic Effect Of 630 Nm Light-Emitting Diodes Irradiation On The Recovery Of Exercise-Induced Hand Muscle Fatigue With Surface Electromyogram, Dandan Yang, Xiaoying Wu, Wensheng Hou, Xiaolin Zheng, Jun Zheng, Yingtao Jiang

Electrical & Computer Engineering Faculty Research

This paper aims to investigate the effect of light emitting diode therapy (LEDT) on exercise-induced hand muscle fatigue by measuring the surface electromyography (sEMG) of flexor digitorum superficialis. Ten healthy volunteers were randomly placed in the equal sized LEDT group and control group. All subjects performed a sustained fatiguing isometric contraction with the combination of four fingertips except thumb at 30% of maximal voluntary contraction (MVC) until exhaustion. The active LEDT or an identical passive rest therapy was then applied to flexor digitorum superficialis. Each subject was required to perform a re-fatigue task immediately after therapy which was the same …

Dr. King's Speech: Surveying The Landscape Of Law And Justice In The Speeches, Sermons, And Writings Of Dr. Martin Luther King, Jr., Carlton Waterhouse

Minnesota Journal of Law & Inequality

No abstract provided.

Smyrna's Ashes: Humanitarianism, Genocide And The Birth Of The Middle East, Michelle Tusan

History Faculty Research

Today the West tends to understand the Middle East primarily in terms of geopolitics: Islam, oil, and nuclear weapons. But in the nineteenth century it was imagined differently. The interplay of geography and politics found definition in a broader set of concerns that understood the region in terms of the moral, humanitarian, and religious commitments of the British empire. Smyrna’s Ashes reevaluates how this story of the “Eastern Question” shaped the cultural politics of geography, war, and genocide in the mapping of a larger Middle East after World War I.

Introduction: Continuity And Change In Russian Culture, Dmitri N. Shalin

Russian Culture

This project on Russian culture goes back to the Spring of 1990 when several American and Russian scholars converged at the Russian Research Center at Harvard University and decided to join forces in a study of changes sweeping the Soviet Union. From the start, the participants agreed that they would not try to chase fast breaking news from Russia -- a hopeless task given the pace of recent changes, but rather would focus on the continuity and change in Russian culture, on the long-term social forces that compel the Russian people to reexamine old ways and reevaluate old values.

Religious Culture: Faith In Soviet And Post-Soviet Russia, Jerry Pankhurst

Russian Culture

The former Soviet Union is undergoing a religious revival. People inside and outside the Russian Orthodox church are reexamining its ancient ways, rediscovering its long-forgotten saints, searching its institutional memory for answers to urgent questions facing the nation. The Western reaction to this remarkable resurgence of religion in Russia has been mixed. All observers welcome the fact that free inquiry about religion and free religious worship have been restored in the Russian Federation. At the same time, many are concerned about the xenophobic tendencies that have accompanied the religious revival in Russia and that became especially evident after the liberal …

Soviet Everyday Culture: An Oxymoron?, Svetlana Boym

Russian Culture

Mikhail Mishin, a Soviet satirist, wrote that Russians recognize themselves in the famous fairy-tale character Ivan the Fool. He bides his time napping on the heated furnace and gets up only to undertake major heroic feats. Ivan the Fool might be a great hero, but he has no idea how to survive his everyday life. Everyday life, captured in the Russian word byt, is a more dangerous enemy to him than the multi-headed fire-spitting dragon. The everyday is Russia 's cultural monster. The nation might worship its heroes and their fabled ability to withstand hell or high water, but …

Literary Culture: "New Soviet Man" In The Mirror Of Literature, Maurice Friedberg

Russian Culture

The roots of Soviet literary culture extend beyond the establishment of the Soviet state itself. Maxim Gorky's Mother written, ironically, some years before the Bolshevik Revolution in the United States (the country, it might be noted, that also contributed to the cause of the tradition of May Day observances) is one hallmark of that culture avant la lettre. Nikolai Chernyshevsky's What Is to Be Done, a novel often cited in Communist hagiographies as the inspiration of generations of nineteenth-century Russian revolutionaries (including, significantly, the founder of Soviet state himself, as well as his martyred brother) is another. And yet, we …

Artistic Culture: The Trial By Freedom, Daniil Dondurei

Russian Culture

"The poet in Russia is more than just a poet." This line from Evgeny Yevtushenko's verse hints at the unique place that artistic culture has occupied in Russia 's tragic history. From Radishchev and Tolstoy to Solzhenitsyn and Tarkovsky, writers, painters, film makers -- cultural producers of every kind -- undertook to explain Russian society to itself. The common view that depicts Soviet art as subservient to ideology is well grounded in facts, but it tends to conceal as much as it reveals. Soviet artists served the state, and thus could not help but being influenced by the nation's poisonous …

Colonizing Chaos: Russian Literature At The End Of The Twentieth Century, Alexander Genis

Russian Culture

Culture sets the parameters of our reality, defines its boundaries, gives each of us a system of values and reference points and, most important, provides our subconscious with the materials necessary for an awareness of chaos and the universe, space and time, cause and effect. Beginning my essay with these broadest categories, I will attempt to sketch the coordinates of that landscape in which the stormy drama of post-Soviet literature is played out. This will be followed by an analysis of the literary situation in the period directly preceding our own. Coming next will be some brief sketches of nine …

Russian Literature In The Christian Context, Boris Paramonov

Russian Culture

In examining Russia’s cultural history one encounters an incontestable fact: the literary nature of its spirituality. At the same time, Russian literature is distinguished by its high caliber. If one examines Russia’s cultural significance in the context of the Western world, or generally attempts to evaluate the nation’s achievements on a Western European scale, one finds that Russian literature stands out with particular distinction. The West places Leo Tolstoy and Dostoyevsky on a par with Shakespeare, while Chekhov’s plays enjoy a popularity comparable with the Bard’s in the sheer number of theatrical performances, even in England, where Chekhov’s Western renown …

The Russian Cinematic Culture, Oksana Bulgakova

Russian Culture

The cinema has always been subject to keen scrutiny by Russia's rulers. As early as the beginning of this century Russia's last czar, Nikolai Romanov, attempted to nationalize this new and, in his view, threatening medium: "I have always insisted that these cinema-booths are dangerous institutions. Any number of bandits could commit God knows what crimes there, yet they say the people go in droves to watch all kinds of rubbish; I don't know what to do about these places." The plan for a government monopoly over cinema, which would ensure control of production and consumption and thereby protect the …

Russian Architecture Between Anorexia And Bulimia, Vladimir Paperny

Russian Culture

The Russian visual sensibilities (if there is such thing) are formed by two contrasting influences. On the one hand, there is a natural attraction to decorative surfaces, to richness of colors and shapes. Historians tell us that in the 10 th century Prince Vladimir decided to convert to Christianity mainly because of the visual experience his emissaries had had in Constantinople: “The Greeks led us to the building where they worship their God,” they wrote to the Prince, “and we knew not whether we were in heaven or on earth. For on earth there is no such splendor or such …

The Art Of Dissent: Parody, Travesty And Irony In Late Soviet Culture, Dmitri N. Shalin

Russian Culture

Irony is the favorite tool of Russian postmodernists fighting discourse totalitarianism. They wield it like a crowbar to pry open in the simulacrum, to tear down the Potemkin portable villages built by forced discursive labor. Every new blow the ironist strikes against the official reality reaffirms his intonational freedom amidst the most coercive discourse. An ultimate weapon of the spiritual proletariat, irony proves to the intellectual that he is a subject rather than an object of discourse. Alas, ironic vigil takes its toll. The self busily disclaiming identity with itself loses track of what it really is. It knows not …

Souls/Soles Of Signs Tell Totems And The Sphinx Wager, Darryl A. Smith M.Div., Ph.D.

Occasional Papers

This paper develops a philosophy of play through an analysis of the foot wager of the Sphinx. Applying a construction of the cosmology of Plato along with a Socratic etymology of her riddle’s answer, it provides a reading of Sphingian contestation consistent with contemporary practices of deception found in modern games like poker. I argue that such deception is constitutive of the excessive illumination of signaling tells in games and that such excess, in turn, is indicative in allied political contexts of a covetous and acquisitive obsession with light. This theory makes use also of Ralph Ellison’s refiguring of Oedipal …

Post-Traumatic Stress Disorder: A Look Into The Cause, Gender Differences, And Treatment, Barbara Wallen

McNair Poster Presentations

Posttraumatic stress disorder, better known as PTSD came to light during the Vietnam Era. Throughout history, this stress disorder has been called various things in the 150 years since it was first recognized. However, each new word had several characteristics in common, such as re-experiencing, numbing and physiological arousal.

The process of Darwinian “natural selection” corroborated the evolution of people with highly developed stress responses. Those pre-historic people with the most useful “fight or flight” reflexes became our ancestors. An example of this is that during the 19^th Century, PTSD was called “Railway Spine” and was associated with what …

Transcriptome Analysis Of Glue Secretion In Drosophila, William Mccurdy, Pawel Parafianowicz, Andrew Andres

McNair Poster Presentations

Steroid hormones control important developmental and physiological responses in animals, including humans. It is known that when a cell is exposed to a steroid hormone, there is an immediate change in the genes that are expressed into proteins. Of notable importance is steroid regulation in the salivary glands of larval Drosophila melanogaster and the corresponding physiological responses that are governed by treatment with the conserved insect steroid, 20-hydroxyecdysone (20E). Exposure to the steroid hormone 20E causes a change in gene expression that facilitates the secretion of glue glycoproteins from inside the cells into the lumen of the tissue. Altered gene …

Hyperactivation Of The Hypothalamo-Pituitary-Adrenocortical Axis In Streptozotocin Diabetic Rats: Effect Of Tinospora Cordifolia (Willd.) And Insulin Therapy, Nagaraja Puranik, Sheela Devi Devi, Kararshaha Kammar

Turkish Journal of Medical Sciences

In the present study, we investigated the extent to which changes in corticosterone level and food and water intake behavior occur in diabetes and explored the effect of Tinospora cordifolia extracts and insulin therapy in streptozotocin-induced diabetic rats. Materials and methods: Female albino rats of the inbred Wistar strain (body weight: 180-210 g) were used in this study. Experimental diabetes was induced by injecting freshly prepared streptozotocin once at the dose of 55 mg/kg body weight intravenously in 0.1 M citrate buffer, pH 4.5. The drug was administered orally for 10 days and 30 days in different groups containing 6 …

Cytotoxic Effect Of Cigarette Smoke Condensate On Mice And Rat Mesenchymal Stem Cells And Hela Cells, Aftab Ahmad, Abdul Rauf Shakoori

Turkish Journal of Medical Sciences

Aim: To study the effect of cigarette smoke condensate (CSC) on HeLa cells and mesenchymal stem cells (MSCs) of mice (mMSC) and rats (rMSC). Cigarette smoking results in the deaths of millions of people annually. The constituents of cigarette smoke produce oxidants in the cells that result in inflammation, carcinogenesis, and apoptosis. Materials and methods: CSC was collected on filter paper and dissolved in dimethyl sulfoxide, and 10-100 µg/mL was added to HeLa cells, mMSCs, and rMSCs in a 96-well plate. The cytotoxic effect of CSC was measured after 48 h using a neutral red uptake assay. Images of the …

Combretazet-3 A Novel Synthetic Cis-Stable Combretastatin-A4-Azetidinone Hybrid With Enhanced Stabilityand Therapeutic Efficacy In Colon Cancer, Lisa M. Greene, Shu Wang, Niamh O'Boyle, Sandra A. Bright, Jane E. Reid, Patrick Kelly, Mary J. Meegan, Daniela M. Zisterer

Articles

In recent years an extensive series of synthetic combretastatin A-4 (CA-4)-azetidinone (β-lactam) hybrids were designed and synthesised with a view to improve the stability, therapeutic efficacy and aqueous solubility of CA-4. Lead compounds containing a 3,4,5-trimethoxy aromatic ring at position 1 and a variety of substitution patterns at positions 3 and 4 of the β-lactam ring were screened in three adenocarcinoma-derived colon cancer cell lines (CT-26, Caco-2 and the CA-4 resistant cell line, HT-29). In both CT-26 and Caco-2 cells all β-lactam analogues analysed displayed potent therapeutic efficacy within the nanomolar range. Substitution of the ethylene bridge of CA-4 with …

Withholding Political Authority: Civil Society And People's Power In Zimbabwe, A. Scott Dupree

Electronic Theses and Dissertations

The relationship of civil society to the state is rarely antagonistic and at most times supportive. The political regime and civil society are taken to be interdependent social structures that interact through hegemonic, supportive and socially constructed dimensions. Given this interdependency, when does civil society challenge authority or does its efforts rise to the level of a people's power revolution? When does it act to dismantle the political regime or seek to reconstruct it? This project attempts to shed light on how civil society mobilizes a people's power capable of challenging political authority through the story of its ongoing struggles …

The Genetics Of Neuroendocrine Prostate Cancers: A Review Of Current And Emerging Candidates, M Hammad Ather, Tahmeena Siddiqui

Department of Surgery Docs

Prostate cancer (PC) displays a strong familial link and genetic factors; genes regulating inflammation may have a pivotal role in the disease. Epigenetic changes control chromosomal integrity, gene functions, and, ultimately, carcinogenesis. The most widely studied epigenetic event in PC is aberrant DNA methylation (hypo- and hypermethylation); besides this, chromatin remodeling and micro RNA (miRNA) are other studied alterations in PC. These all lead to genomic instability and inappropriate gene expression. Causative dysfunction of histone modifying enzymes results in generic and locus-specific changes in chromatin remodeling. miRNA deregulation also contributes to prostate carcinogenesis, including interference with androgen-receptor signaling and apoptosis. …

Reality Television And Its Effect On The Academic Achievement Of Inner-City High School Students, Natifia Mullings

Communication & Leadership Dissertations and Theses

The impact of heavy television viewing and the effects it has on young viewers has been a dominant topic since the 1960s. With the ever-changing landscape of television programming, reality television has become increasingly popular, especially among the pre-teen and teen audiences. This study explores George Gerbner‘s Cultivation Theory (1998), which assumes that television has the ability to influence the attitudes and perceptions of its viewers, and uses it as a foundation to determine if there is an association between reality television consumption and the attitudes inner-city high school students have towards education. A total of 251 inner-city high school …

An Investigation Into The Neural Substrates Of Virtue To Determine The Key Place Of Virtues In Human Moral Development, Andrew P.J Mullins

Theses

Virtues, as described by Aristotle and Aquinas, are understood as dispositions of character to behave in habitual, specific, positive ways; virtue is a critical requirement for human flourishing. From the perspective of Aristotelian-Thomistic anthropology which offers an integrated vision of the material and the rational in the human person, I seek to identify the neural bases for the development and exercise of moral virtue. First I review current neuroscientific knowledge of the capacity of the brain to structure according to experience, to facilitate behaviours, to regulate emotional responses and support goal election. Then, having identified characteristics of moral virtue in …

This Just In: Breaking News With Social Media By The Newspaper Organizations In The Southwestern Corner Of New York State, Chris Chapman

Communication & Leadership Dissertations and Theses

Social media is the newest form of technology to tempt journalists. What is it? How can it be used to bring their information to the consumers? This thesis examines the ability of eight papers in the southwestern corner of New York state to break news on social media like Facebook and Twitter. The study, conducted by a survey of the journalists working for those papers, takes a look at the policies that govern social media within their organization. Through the lens of the agenda-setting theory, the data shows that the rural region of New York state has yet to find …

Bridging The Gap Between Academic And Practical Crisis Response Strategy Using A Public Risk Perception Model, Kyle Davidson

Communication & Leadership Dissertations and Theses

As risk is inherent in any profitable or viable business, it can be assumed that at some point an organization may face a crisis stemming from known or unknown risks. As such, it is important for organizations to understand how to respond to crises. Crisis communication really has one simple goal in mind: to minimize the effects of the crisis on the organization’s reputation. William Benoit’s “Image Restoration Theory” and Timothy Coombs’ “Situational Crisis Communication Theory” set a framework for how organizations can respond successfully in crisis situations. Yet much of the contemporary academic theory fails to translate from academic …

Disease-Branding And Drug-Mongering: Could Pharmaceutical Industry Promotional Practices Result In Tort Liability?, Jason S. Cetel

Student Works

No abstract provided.

Regulating The Sex Trade, John Avery

Student Works

No abstract provided.

Killing For Possession And Killing For Survival: Gender And The Criminal Law Of Provocation And Self-Defense, Danielle Rosiejka

Student Works

No abstract provided.