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Implementation Of Medicinal Leech Preparation To Investigate The Connection Between The Motor Neuron And Muscle Fiber Via Sharp Electrode Electrophysiology, Chandra Nikole Miller

Master's Theses

There are forty registered organophosphates in the United States and they range from pesticides and insecticides to nerve agents or neurotoxins such as sarin. Organophosphates (OP’s) have been used in chemical warfare for years and tend to lead to death due to an attack on the nervous system. Chemical assays and mass microscopy have been used to assess the concentration of OP’s in the environment, but both methods require the body to metabolize the OP first, which can be detrimental to the victim. It is crucial to come up with a method to investigate and detect these neurotoxins without causing …

Impact Of Collateral Enlargement On Smooth Muscle Phenotype, Alexander Jerome Bynum

Master's Theses

Peripheral Artery Disease is a very serious disease characterized by an arterial occlusion due to atherosclerotic plaques. In response to an arterial occlusion, arteriogenesis occurs, causing smooth muscle cells to transition from a contractile to synthetic state. Also following an arterial occlusion, functional impairment was seen in the collateral circuit. An immunofluorescence protocol was developed in order to assess the impact of collateral enlargement (arteriogenesis) on smooth muscle phenotype at various time points. Smooth muscle α-actin was used to mark all smooth muscle cells, Ki-67 was used to label proliferating smooth muscle cells, and a fluorescent nuclear stain was used …

Fear And Fascination: A Study Of Thomas Hardy And The New Woman, Anita Sandlin

College of Graduate Studies: Theses & Dissertations

The tragic outcomes of most of his fictional heroines have led many to accuse Thomas Hardy of being a misogynist, harshly punishing women for their open defiance of Victorian social expectations. However, by writing about sexually-charged issues at a time when subjects such as premarital sex, rape, illegitimate children, adultery, and divorce were taboo, Hardy challenged his readers to consider the destructive power caused by hypocrisy and double standards, making many consider him to be among the first feminists. These conflicting perspectives reflect the internal ambiguities of a gifted man torn between wanting to maintain the conservative comfort of the …

Annual Financial Report 2011, University Of Montana--Missoula

University of Montana Annual Financial Reports, 1918-2012

University of Montana annual financial report for fiscal year ending June 30, 2011.

Curriculum Subcommittee Agenda, December 1, 2011, Utah State University

Educational Policies Committee

Department of Animal, Dairy and Veterinary Sciences

• New Course
• Credit Hour Change
• Title Change, Course Description Change
• Credit Hour Change, Course Description Change
• Title Change, Credit Hour Change, Course Description Change
• Inactivate Course
• Delete Course

Department of Nutrition, Dietetics and Food Sciences

• Credit Hour Change

School of Applied Sciences, Technology and Education

• Title Change, Prerequisite Change, Description Change
• Title Change, Description Change
• Title Change, Credit Hour Change, Prerequisite Change, Description Change
• Title Change

Department of Art and Design

• University Studies Request

Department of Theatre Arts

• Prerequisite Change
• Title Change, Prerequisite Change
• Title Change, Credit Hour Change, Prerequisite Change, Course Description …

Transient Receptor Potential Channel M4 And M5 In Magnocellular Cells In Rat Supraoptic And Paraventricular Nuclei, R. Teruyama, M. Sakuraba, H. Kurotaki, W. E. Armstrong

Faculty Publications

The neurohypophysial hormones, vasopressin (VP) and oxytocin (OT), are synthesised by magnocellular cells in the supraoptic nucleus (SON) and the paraventricular nucleus (PVN) of the hypothalamus. The release of VP into the general circulation from the neurohypophysis increases during hyperosmolality, hypotension and hypovolaemia. VP neurones increase hormone release by increasing their firing rate as a result of adopting a phasic bursting. Depolarising after potentials (DAPs) following a series of action potentials are considered to be involved in the generation of the phasic bursts by summating to plateau potentials. We recently discovered a fast DAP (fDAP) in addition to the slower …

Repetitive Elements May Comprise Over Two-Thirds Of The Human Genome, A. P.Jason De Koning, Wanjun Gu, Todd A. Castoe, Mark A. Batzer, David D. Pollock

Faculty Publications

Transposable elements (TEs) are conventionally identified in eukaryotic genomes by alignment to consensus element sequences. Using this approach, about half of the human genome has been previously identified as TEs and low-complexity repeats. We recently developed a highly sensitive alternative de novo strategy, P-clouds, that instead searches for clusters of high-abundance oligonucleotides that are related in sequence space (oligo "clouds"). We show here that P-clouds predicts >840 Mbp of additional repetitive sequences in the human genome, thus suggesting that 66%-69% of the human genome is repetitive or repeat-derived. To investigate this remarkable difference, we conducted detailed analyses of the ability …

Infectious Disease And The Worldwide Distribution Of Iq, Christopher Guiles Eppig

Biology ETDs

We show that infectious disease is a major contributor to the worldwide distribution of human cognitive ability, as measured by psychometric IQ. In areas where infectious disease is high, average human intelligence tends to be lower, and in areas where infectious disease is low, average human intelligence tends to be higher. In separate studies, we tested this across world nations (chapter 2) and across states of the USA (chapter 3). In efforts to disseminate our research to wider audiences, I reviewed the findings contained in chapters 2 and 3 using language that is accessible to non-biologists (chapter 4). Although it …

Lateralization Of The Developing Rat Hippocampal Formation, Amanda Lynn Gross

Biology ETDs

Differences between the left and right hemisphere of the brain have been observed in humans and rodents (Broca, 1861; Wernicke, 1881), including the hippocampal formation, a region of the brain that is necessary for some forms of learning and memory (Olton and Samuelson, 1976; deToledo-Morrell et al., 1988; Bernasconi-Guastalla et al., 1994; Tabibnia et al., 1994; Poe et al., 2000; Lister et al., 2006; Hanlon et al., 2005; Sommer et al., 2005; Moskal et al., 2006; Thompson et al., 2008; Klur et al., 2009). Although lateralization of the hippocampal formation has been studied in the adult, few have sought to …

The Pan American (2011-12-01), Alma E. Hernandez, Roxann Garcia

UTPA Archives - The Pan American Newspaper

Vol. 68, No. 12

Production And Fate Of Transparent Exopolymer Particles In The Ocean, Oliver Wurl, Lisa Miller, Svein Vagle

OES Faculty Publications

The production and fate of transparent exopolymer particles (TEP) have been investigated in various oceanic regions (tropical, temperate, and polar), from the sea surface microlayer (SML) to the deep ocean. Accumulation of TEP within the mixed layer was observed even in the absence of phytoplankton blooms, indicating abiotic processes are important in TEP production. The abiotic TEP aggregation rates measured in the tropical and temperate North Pacific and the Arctic Ocean averaged between 8 and 12 μmol C L^-1 d-¹. Depth profiles from under sea ice in the Arctic revealed the highest TEP concentrations, potentially released by …

Electrical Detection Of Mechanical Resonance In Nanotubes And Semiconducting Nanowires, Doyl Dickel

All Dissertations

In recent years, there has been substantial interest in the development of microelectro-mechanical systems (MEMS) and even nanoelectro-mechanical systems (NEMS) for use in a wide variety of applications both as experimental tools (refs) and in a continuing effort to decrease the size and cost and increase the efficiency of electrical components. In particular, cantilevered nanometer beams have been a recent focus due to a number of interesting properties, including enhanced field emission, high tensile strength, and piezoelectric properties. The ability to accurately determine the electrical and mechanical properties of these cantilevers is paramount in assessing their feasibility as MEMS and …

An Examination Of Adaptive Leadership Processes Using Action Research, Margaret Bright

All Dissertations

School districts are knowledge producing organizations faced with adaptive challenges that require new learning, innovation, and new patterns of behavior. Traditional, entity-based models of leadership rely on the knowledge of only a handful of leaders at the top of the bureaucratic ladder and fail to tap collective creativity inherent at all levels of a school or district. The purpose of this study was to engage in action research to identify emergent, interactive dynamics that resulted in a creative solution to an adaptive special education problem of closing the achievement gap for students with disabilities in one geographical area of a …

Single Particle And Ensemble Spectroscopy Of Conjugated Polymer Nanoparticles And Their Development For Photodynamic Therapy, Jennifer Grimland

All Dissertations

Energy transport in conjugated polymers is the combination of energy transfer and exciton diffusion. There is considerable ongoing research in this field, converging to develop better organic photovoltaics, polymer light emitting diodes (PLEDs) and organic solar cells, to name a few. One way these phenomena can be explored is by doing solution dependent studies on conjugated polymer nanoparticles. With experiments on CP dots in an aqueous solution and the addition of a water miscible organic solvent in varying concentrations, dynamics occurring in the folding process can be better understood, and also exciton and fluorescence quenching properties can be extracted as …

A Tale Of Two Eddies: Diagnosing Coherent Eddies Through Acoustic Remote Sensing, T. Rossby, C. Flagg, P. Ortner, C. Hu

Marine Science Faculty Publications

A 38 kHz vessel-mounted acoustic Doppler current profiler is used to explore in detail the dynamics of an anticyclonic and a cyclonic eddy during two transits of the cruise vessel Explorer of the Seas from the Caribbean to New Jersey in July 2007. The radial scale of the two eddies is similar, but whereas the cyclone is strongly surface intensified, the anticyclone has its maximum expression with near–solid body rotation between 200 and 800 m depth. The anticyclone has a minimum in relative vorticity very close to −f at 800 m depth and the cyclone has a maximum of about …

Jay Meijia On Bipolar Disorder, Hillary Mulan

The Synapse: Intercollegiate science magazine

No abstract provided.

A Qualitative Case Study That Explores The Use Of Visual Thinking Journals In An Urban Arts Magnet High School, Shannon E. Machina

Art Education Projects

This qualitative case study research project investigated the question, “What can be learned from a study that explores how an art teacher uses visual thinking journals and how students respond to the use of visual thinking journals in an urban arts high school setting?” The participants of this study were the art educator Mrs. Carlson and the students enrolled in her ninth grade Graphic Design and 12^th grade Advanced Drawing and Painting courses. Over an eight week period data was collected and analyzed utilizing constructivist pedagogy to investigate the variety of ways high school art teachers and students …

Pulmonary Endothelial Calcium Entry Following Chronic Hypoxia, Steven D. Menicucci

Biomedical Sciences ETDs

Background and Specific Aims: Chronic hypoxia (CH) induced pulmonary hypertension is mediated in part by endothelial dysfunction, involving reduced intracellular Ca2+ levels and decreased production of endothelium-derived vasodilators and anti-mitogenic compounds. Agonist-induced endothelial Ca2+ entry is decreased following CH due to a derangement in T-type voltage-gated calcium channels (T-channels) and caveolin-1 containing membrane lipid domains that regulate calcium influx in these cells. Considering the importance of store-operated Ca2+ entry (SOCE) to agonist-induced Ca2+ entry, we hypothesized that CH impairs pulmonary endothelial SOCE through altered caveolin-1 regulation of T-channels. To test this hypothesis, we addressed the following specific aims: Specific Aim …

Role Of Endothelial Bkca Channel Activity In Diminished Vasoconstrictor Reactivity Following Chronic Hypoxia, Melissa Anne Riddle

Biomedical Sciences ETDs

Vasoconstrictor responsiveness of the systemic circulation is attenuated following prolonged exposure to hypoxia. Previous work from our laboratory has demonstrated vasoconstrictor reactivity is diminished due to hyperpolarization of the vascular wall in systemic arterioles. The hyperpolarization of the vascular wall was found to be dependent upon the endothelium, heme oxygenase (HO), and calcium-activated large conductance potassium channel (BKCa) as removal of the endothelium or blockade of HO or BKCa restored vasoreactivity. Interestingly, recent evidence for HO and BKCa association has emerged in carotid body glomus cells where HO and BKCa form oxygen sensing complexes. In these novel oxygen sensing complexes, …

Functional Genomics Reveals An Essential And Specific Role For Stat1 In Protection Of The Central Nervous System Following Herpes Simplex Virus Corneal Infection, Tracy J. Pasieka, Cristian Cilloniz, Victoria S. Carter, Pamela Rosato, Michael G. Katze, David A. Leib

Dartmouth Scholarship

Innate immune deficiencies result in a spectrum of severe clinical outcomes following infection. In particular, there is a strong association between loss of the signal transducer and activator of transcription (Stat) pathway, breach of the blood-brain barrier (BBB), and virus-induced neuropathology. The gene signatures that characterize resistance, disease, and mortality in the virus-infected nervous system have not been defined. Herpes simplex virus type 1 (HSV-1) is commonly associated with encephalitis in humans, and humans and mice lacking Stat1 display increased susceptibility to HSV central nervous system (CNS) infections. In this study, two HSV-1 strains were used, KOS (wild type [WT]), …

Application Of Threshold Concepts To Improve A Design-Focused Course In Transportation Engineering, Dan Cernusca, Ghulam Bham

Civil, Architectural and Environmental Engineering Faculty Research & Creative Works

Design is an integral part of engineering courses. to address its associated problems, however, is a challenging task in instruction because of design's open-endedness and complexity. in this study, two theoretical models were implemented in an introductory transportation engineering course to address the challenges associated with design of a highway. First, the theoretical framework proposed by the threshold concepts model was used to identify a candidate concept for the instructional redesign process. Two major characteristics of threshold concepts, integrativity and transformativity, were used to identify horizontal alignment as a candidate concept for the highway design process. Second, concept mapping was …

Perceived Peer Social Support Dan Psychological Distress Mahasiswa Universitas Indonesia, Astri Dewayani, Augustine D. Sukarlan, Sherly S. Turnip

Makara Human Behavior Studies in Asia

This study investigated the difference of psychological distress between students of Universitas Indonesia who have and who does not have perceived peer social support. This quantitative study has been done by adapting HSCL-25 questionnaire to know psychological distress to differentiate students of Universitas Indonesia who perceived peer social support. Participants are 666 students of Universitas Indonesia obtained by random/probability sampling. There is no significant difference in psychological distress between students of Universitas Indonesia who have and who does not have perceived peer social support. It is assumed that there are many other factors that influence the psychological distress student.

Developing A Strawberry Yogurt Fortified With Marine Fish Oil 1, J. D. Estrada, C. Boeneke, P. Bechtel, S. Sathivel

Faculty Publications

Fortified dairy products appeal to a wide variety of consumers and have the potential to increase sales in the yogurt industry and help increase intake of long-chain n-3 fatty acids. The objectives of this study were to develop a strawberry yogurt containing microencapsulated salmon oil (MSO; 2% wt/vol) and evaluate its characteristics during 1 mo of storage. Unpurified salmon oil (USO) was purified (PSO) and both USO and PSO were analyzed for peroxide value (PV), anisidine value (AV), total oxidation, free fatty acids (FFA), and moisture content. A stable emulsion was prepared with 7% PSO, 22% gum arabic, 11% maltodextrin, …

Laboratory Host Range Assessment Of A Predatory Pentatomid, Podisus Maculiventris (Hemiptera: Pentatomidae) For Field Release On Guam, Gadi V.P. Reddy, Rosalie Kikuchi

Faculty Publications

Predation by Podisus maculiventris (Say) (Hemiptera: Pentatomidae) was evaluated with Erionota thrax (L.) (Lepidoptera: Hesperidae), Pericyma cruegeri (Butler) (Lepidoptera: Noctuidae), Pareuchaetes pseudoinsulata Rego Barros (Lepidoptera: Arctiidae), Papilio polytes (L.) (Lepidoptera: Papilionidae) and Eudocima phalonia (L.) comb. nov. (Lepidoptera: Noctuidae). Both free-choice and no-choice experiments indicated that the P. maculiventris attacked and consumed all the larvae of the 5 species included in the tests. Although the larvae died at different intervals, most of them were dead within 24120 h of the introduction of the predatory species. Since the P. maculiventris is polyphagous in nature and the present findings indicate that these …

Effect Of Soil Type And Exposure Duration On Mortality And Transfer Of Chlorantraniliprole And Fipronil On Formosan Subterranean Termites (Isoptera: Rhinotermitidae), Bal K. Gautam, Gregg Henderson

Faculty Publications

The uptake and potential transfer of chlorantraniliprole and fipronil by the Formosan subterranean termite, Coptotermes formosanus Shiraki, was investigated in the laboratory by using donor-recipient model bioassays. Two different types of substrates, sandy loam soil (18.6% organic matter) and sand (0.19% organic matter), were used to evaluate how these treated substrates impact the direct mortality and transfer efficiency of the two nonrepellent termiticides tested at different concentrations. Chlorantraniliprole exhibited a more delayed mortality on termites than fipronil in sand. In soil, chlorantraniliprole did not cause higher mortality to either donor or recipient termite at any of the tested concentrations during …

Efficacy Of Genetically Modified Bt Toxins Against Insects With Different Genetic Mechanisms Of Resistance, Bruce E. Tabashnik, Fangneng Huang, Mukti N. Ghimire, B. Rogers Leonard, Blair D. Siegfried, Murugesan Rangasamy, Yajun Yang, Yidong Wu, Linda J. Gahan, David G. Heckel, Alejandra Bravo, Mario Soberón

Faculty Publications

Transgenic crops that produce Bacillus thuringiensis (Bt) toxins are grown widely for pest control, but insect adaptation can reduce their efficacy. The genetically modified Bt toxins Cry1AbMod and Cry1AcMod were designed to counter insect resistance to native Bt toxins Cry1Ab and Cry1Ac. Previous results suggested that the modified toxins would be effective only if resistance was linked with mutations in genes encoding toxin-binding cadherin proteins. Here we report evidence from five major crop pests refuting this hypothesis. Relative to native toxins, the potency of modified toxins was >350-fold higher against resistant strains of Plutella xylostella and Ostrinia nubilalis in which …

Alu Pair Exclusions In The Human Genome, George W. Cook, Miriam K. Konkel, James D. Major, Jerilyn A. Walker, Kyudong Han, Mark A. Batzer

Faculty Publications

Background: The human genome contains approximately one million Alu elements which comprise more than 10% of human DNA by mass. Alu elements possess direction, and are distributed almost equally in positive and negative strand orientations throughout the genome. Previously, it has been shown that closely spaced Alu pairs in opposing orientation (inverted pairs) are found less frequently than Alu pairs having the same orientation (direct pairs). However, this imbalance has only been investigated for Alu pairs separated by 650 or fewer base pairs (bp) in a study conducted prior to the completion of the draft human genome sequence. Results: We …

Production Of F 1 Offspring With Vitrified Sperm From A Live-Bearing Fish, The Green Swordtail Xiphophorus Hellerii, Rafael Cuevas-Uribe, Huiping Yang, Jonathan Daly, Markita G. Savage, Ronald B. Walter, Terrence R. Tiersch

Faculty Publications

This study reports the first production of offspring with vitrified sperm from a live-bearing fish Xiphophorus hellerii. The overall goal of this study was to develop streamlined protocols for integration into a standardized approach for vitrification of aquatic species germplasm. The objectives were to (1) estimate acute toxicity of cryoprotectants, (2) evaluate vitrification solutions, (3) compare different thawing methods, (4) evaluate membrane integrity of post-thaw sperm vitrified in different cryoprotectants, and (5) evaluate the fertility of vitrified sperm. Nine cryoprotectants and two commercial vitrification additives were tested for acute toxicity and glass forming ability, alone and in combination. Two vitrification …

Magnesium, A Drug Of Diverse Use, Mohammad Irfan Akhtar, Hameed Ullah, Mohammad Hamid

Department of Anaesthesia

Magnesium has evolved as a drug with diverse clinical applications. Mg++ is an important caution and its homeostasis is very important for normal body functioning. The physiological role of Mg is due to its calcium channel blocking properties at smooth muscle, skeletal muscle and conduction system levels. The analgesic properties are due to NMDA receptor blocking action. Mg++ is beneficial in acute Myocardial Infarction, protection during open heart surgery and treatment and prevention of heart rhythm disturbances. Mg has an established role in the management of preeclampsia and eclampsia. Magnesium prevents or controls convulsions by blocking neuromuscular transmission and decreasing …

Cross-Cultural Readings Of Intent: Form, Fiction, And Reasonable Expectations, Deborah Waire Post

Scholarly Works

No abstract provided.