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Cobalt-Substituted Hydroxyapatite As A Potential Basis Of Biomaterials: Synthesis, Crystal-Chemistry Properties And Antibacterial Activity, Maria M. Vlasova, Ksenia S. Stasenko, Evgeny Bulanov

Turkish Journal of Chemistry

This paper presents the results of the synthesis of solid solutions of cobalt-substituted hydroxyapatite of the composition Ca10-xCox(PO4)6(OH)2 by the solid-phase and solution method. The formation of only the composition of Ca9.5Co0.5(PO4)6(OH)2 has been reliably established, whereas an increase in the cobalt content, as well as an increase in the temperature of synthesis and calcination of the samples prepared in solution, leads to the formation of stable mixtures of calcium and cobalt phosphates. The crystal structure has been refined for Ca9.5Co0.5(PO4)6(OH)2 (a = 9.4121(28) Å, c = 6.8762(20) Å, V = 527.54(35) Å3; R-Bragg = 2.455%) under the assumption of …

Cover And Contents

Turkish Journal of Agriculture and Forestry

No abstract provided.

The Effect Of Seedling Age On Nickel (Ni) Accumulation In Maize (Zea Mays L.), Tuba Göçergi̇l, Hava Şeyma İnci̇

Turkish Journal of Agriculture and Forestry

One of the most significant problems facing different ecosystems worldwide is the pollution of soil and water resources with heavy metals, which are harmful to biota. Metals are absorbed by plant roots through soil-plant interaction, leading to accumulation in plants. The plant's growth phase is one of the most important factors in heavy metal uptake and accumulation. Among heavy metal elements, nickel is one of the serious environmental pollutants and plant growth inhibitors due to its toxicity and persistent nature at high concentrations, as well as its bioaccumulation in ecosystems. This study aims to investigate how nickel accumulation in plant …

Species-Specific Metal Uptake Thresholds In Riparian Macrophytes: A Biological Framework For Ecological Risk Assessment, Reyhan Sağlam, Ferhat Gökbulak

Turkish Journal of Agriculture and Forestry

Anthropogenic pressures on freshwater ecosystems have increased metal contamination in riparian zones; however, biological thresholds that distinguish tolerable exposure from ecologically significant accumulation remain poorly defined. This study investigated species-specific thresholds for heavy metal uptake in riparian macrophytes to establish a biologically grounded framework for ecological risk assessment in impacted streams. A gradient encompassing five sites was used to sample four dominant macrophyte species: Typha latifolia, Phragmites australis, Lythrum salicaria, and Persicaria lapathifolia. Concentrations of cadmium (Cd), chromium (Cr), copper (Cu), iron (Fe), nickel (Ni), lead (Pb), and zinc (Zn) in aboveground plant biomass were examined in relation to their …

Integrating Fine-Scale Topography And Stand Structure To Explain Herb-Layer Diversity In Forest Ecosystems, Carla-Maria Aparaschive, Paul Sestras, Alina M. Truta, Irina M. Morar, Catalina Dan, Monica Boscaiu, Florin Ioras, Adriana F. Sestras

Turkish Journal of Agriculture and Forestry

Herb-layer diversity in temperate forests emerges from the interaction between stand structure and fine-scale environmental variation. We studied eight mixed beech–hornbeam and oak–hornbeam plots distributed along a short altitudinal gradient (170–310 m) and contrasting slope aspects in East Europe. For each plot, we measured tree diameter, height and crown-base height, and derived stand structural indices (tree density, basal area, Gini coefficients for DBH diameter at breast height and total height, and median crown base height). Herb-layer communities were characterized using standard diversity indices and Ellenberg indicator values. We then used Jaccard similarity to explore tree–herb cooccurrence and Spearman correlations to …

Strigolactone-Mediated Regulation Of Physiological, Biochemical, And Gene Expression Responses Enhances Salinity Tolerance In Strawberry (Fragaria × Ananassa), Nora M. Al Aboud, Aishah Alatawi, Maryam Maryam, Mi̇kdat Şi̇mşek, Adel A. Rezk, Hossam S. El-Beltagi, Bader Y. Alsubaie, Othman Al-Dossary, Ahmed M. Ismail, Anvar İbrahimov

Turkish Journal of Agriculture and Forestry

Salinity stress is a limiting factor that restricts growth, physiology, and fruit quality of strawberry (Fragaria × ananassa), particularly in irrigated and arid regions across the globe. The current investigation focused on unveiling the role of strigolactone (GR24, 5 µM) in the mitigation of NaCl-induced stress (100 mM) under greenhouse conditions. Salinity stress massively reduced plant performance, including fresh biomass (16.5 g), dry biomass (4.3 g), photosynthetic rate (7.9 μmol CO2 m−2 s−1), and fruit yield (6 fruits per plant), along with a decline in fruit quality (7.2 °Brix). In contrast, foliar application of strigolactone sig-nificantly enhanced the growth and …

The Diamond, October 16, 2026, Dordt University

Dordt Diamond

• Front Page: Defender Days Sports Preview: What's Going on this Weekend?; Two Years of Collaboration Bring Perennial Game to Iowa Schools; Student Engagement in Midterm Elections
• Feature: Baja Buggy Blast: Dordt Students Build Offroad Racing Vehicle; Caffeine Craze: Coffee Habits on a College Campus; At Large: Campus Cats and What They Can Tell Us; The Truth About Office Hours; Celebrating Scholarship: "Dordt Writes" on October 16; Dordt's New Symphonic Band
• News: El Niño: What It Is and Its Impacts for 2026; Dordt University Ranks Among Top Christian Colleges Nationally; Behind the Break: A Look Inside the Heartland Conference Weekend
• Politics: …

Cover And Contents

Turkish Journal of Biology

No abstract provided.

The Collagen-Derived Tripeptide Gly-Pro-Hyp Suppresses Fgf-5 Expression And Promotes Anagen Induction In C3h/Hej Mice, Yun-Ho Kim, Jin Seok Kim, Woong Yong Kim, Hyun Jung Jo, Zhe Piao, Yeo Cho Yoon

Turkish Journal of Biology

Background/aim: Collagen-derived peptides have shown potential in promoting hair growth, yet their effects on catagen-inducing factors remain unexplored. In this study, the hair growth-promoting effects and molecular mechanisms of Collagen-Tripep20 (CTP), a collagen tripeptide preparation containing 3.2% Gly-Pro-Hyp (GPH), were explored, with a specific focus on fibroblast growth factor 5 (FGF-5) regulation.

Materials and methods: Female C3H/HeJ mice were randomly assigned to four groups (n = 10/group): control, CTP-LOW (400 mg/ kg/day), CTP-HIGH (800 mg/kg/day), and GPH (25.6 mg/kg/day). Following dorsal depilation, test substances were administered dailyvia oral gavage for 7 weeks. Hair regrowth was assessed by visual scoring, histological …

Pifithrin-Α Enhances Ex Vivo Hematopoietic Stem Cell Expansion, Nesli̇han Meri̇ç, Pinar Çolakoğlu Erkan, Fati̇h Kocabaş

Turkish Journal of Biology

Background/aim: Hematopoietic stem cells (HSCs) are essential for treating hematological disorders; however, their low abundance and limited proliferative capacity restrict their clinical use. This study investigated whether pifithrin-α (PFT-α), a small-molecule p53 inhibitor with known genoprotective properties, could enhance the ex vivo expansion of HSCs.

Materials and methods: Mouse lineage-negative (Lin⁻) cells were isolated by magnetic depletion, while human umbilical cord blood (hUCB) and mouse bone marrow (mBM) mononuclear cells were obtained using density gradient centrifugation. CD34⁺ cells were subsequently isolated by fluorescence-activated cell sorting using an antimouse CD34 antibody. The isolated cells were cultured in StemSpan SFEM II (STEMCELL …

Anti-Helicobacter Pylori Activity Of Polycation-Coated Plga Nanoparticles Loaded With Juglone–Silver Complex, Tural Safarov, Emrah Şefi̇k Abamor, Serap Acar, Murat Topuzoğullari, Bükre Kiran Üner, Kübra Karadaş, Seçi̇l Kaya, Zi̇şan Toprak

Turkish Journal of Biology

Background/aim: The rising antibiotic resistance of Helicobacter pylori requires the development of novel treatment approaches. Although natural products (e.g., juglone (5-hydroxy-1,4-naphthoquinone)) and metal antimicrobials (e.g., silver) hold some promise as alternatives, drawbacks like the toxicity and instability of these materials limit their clinical use. Combining juglone and silver with coordination bonds can overcome these drawbacks and yield a more effective antimicrobial complex.

Materials and methods: Juglone–silver (J–Ag) complex was synthesized, encapsulated into PLGA nanoparticles (J–Ag@PLGA), and coated with Eudragit (J–Ag@PLGA+eu). Structural and physicochemical properties of the produced samples were examined using MALDI-TOF MS, FTIR, and UV–Vis spectroscopies; dynamic light scattering; …

Understanding Antimicrobial Peptide Activation In Mesenchymal Stem Cells Through The Aryl Hydrocarbon Receptor Pathway And Inflammatory Signals, Cansu Özdemi̇r Saka, Beyza Turgut, Ceren Tuncay, Cemi̇l Can Eylem, Emi̇rhan Nemutlu

Turkish Journal of Biology

Background/aim: Antimicrobial peptides (AMPs) are small peptides involved in host defense and have been widely studied for their roles in innate immunity against microbial pathogens. Mesenchymal stem cells (MSCs), which provide stromal support in tissues such as bone marrow, are also capable of secreting AMPs, although the signaling pathways controlling this function remain unclear. The present study investigates the role of the aryl hydrocarbon receptor (AHR) signaling, a xenobiotic response pathway, in AMP production by MSCs.

Materials and methods: To assess AMP activation, human MSCs were stimulated with the agonist FICZ and antagonist SR1. TNF-α + IL-1β and LPS were …

Design And Synthesis Of A Novel Benzoxazine-Based Fluorophore With Potential For Lipid Droplet Targeting In Cancer Cells, Eda Açikgöz, Burak Kuzu, Mustafa Çakir

Turkish Journal of Biology

Background/aim: Fluorescence-based visualization of lipid droplets is essential for understanding lipid-related mechanisms in cancer and other metabolic diseases. This study aimed to design and evaluate a novel benzoxazine-based fluorescent probe for selective lipid droplet imaging compatible with multiplexed fluorescence applications.

Materials and methods: A novel benzoxazine-based fluorophore (EA), inspired by the structural features of Nile Red, was synthesized via a two-step strategy. Structural characterization was performed using nuclear magnetic resonance and high-resolution mass spectrometry. Biological performance was assessed in cancer cells under fixed- and live-cell imaging conditions, including cytotoxicity evaluation and compatibility with dual staining.

Results: EA selectively localized to …

Msx2 Is An Erα-Associated Transcription Factor That Sustains Proliferative Capacity And Is Associated With Favorable Prognosis In Luminal Breast Cancer​​, Gamze Turan, Eli̇f Kansiz, Gözde Korkmaz, Hande Özkan

Turkish Journal of Biology

Background/aim: Breast cancer (BC) is the most frequently diagnosed malignancy among women and exhibits substantial molecular heterogeneity. Luminal tumors represent the largest molecular subtype and are primarily driven by estrogen receptor alpha (Erα), ahormone-dependent transcription factor (TF) that regulates gene expression programs controlling proliferation, differentiation, and endocrine response. Herein, the study aimed to identify functionally relevant TFs regulated by ERα as part of a complex regulatory program in luminal BC.

Materials and methods: An integrative transcriptomic approach was applied to identify TFs regulated by ERα in luminal BC. Differential gene expression analysis was integrated with RNA-seq data obtained from estrogen …

Comparison Of Tnfα, Ifnγ, And Dss In Modeling Inflammatory Bowel Disease In Murine Enteroids And Assessment Of The Role Of Zonulin Inhibitor Larazotide Acetate, Sema Nur Gür, Burcu Pervi̇n, Mehmet Emi̇n Şeker, Fati̇ma Aerts Kaya

Turkish Journal of Biology

Background/aim: Inflammatory bowel disease (IBD) is characterized by chronic inflammation of the gastrointestinal tract. We hypothesized that the zonulin inhibitor larazotide acetate (LA), designed to regulate loss of tight junctions between intestinal cells and currently used for the treatment of celiac disease, could also have potential therapeutic value in the treatment of IBD.

Materials and methods: BALB/c enteroids were exposed to dextran sulfate sodium (DSS), tumor necrosis factor-alpha (TNFα), or interferon-gamma (IFNγ) for 48 h to induce an IBD-like environment, followed by treatment with LA. Organoids were assessed for intestinal permeability, viability, and expression of the zonulin (Hp), occludin (Ocln), …

Targeting Mitochondrial And Inflammatory Pathways In Abdominal Aortic Aneurysm: Discovery Of Sigma-1 And Ppar-Γ Agonists Through Plasma Microrna Profiling, Defne Çiğ Kabakcioğlu, İrem Peker Eyüboğlu, Medi̇ Kori̇, Fatma Betül Çeli̇k, Semra Meli̇s Soyer, Mustafa Çalişkan, Can Erzi̇k, Kazim Yalçin Arga, Ceyda Kasavi̇

Turkish Journal of Biology

Background/aim: Abdominal aortic aneurysm (AAA) is a life-threatening vascular disease marked by progressive aortic dilation, high rupture-associated mortality, and a complete lack of effective pharmacological therapies. Because microRNAs (miRNAs) are key regulators of vascular inflammation, extracellular matrix remodeling, and smooth muscle cell function, they represent highly promising therapeutic targets. The aim of this study was to employ an integrative systems biology framework to identify novel miRNA-drug regulatory axes for AAA intervention.

Materials and methods: AAA transcriptome data were integrated with experimentally validated miRNA–mRNA interactions to prioritize candidate miRNAs. A total of 22 previously unreported miRNAs were selected for further analysis. …

Resveratrol Modulates Oxidative Stress-Associated Responses And Restores Keratinocyte Migration Following Lps-Induced Inflammatory Injury, Şeyma Dümür, Burcu Bi̇lteki̇n, Hafi̇ze Uzun

Turkish Journal of Biology

Background/aim: Persistent inflammation disrupts keratinocyte migration and contributes to delayed wound healing. Lipopolysaccharide (LPS)-induced inflammatory models are widely used to investigate impaired reepithelialization and inflammatory cellular dysfunction. Resveratrol, a naturally occurring polyphenolic compound, exhibits antiinflammatory and antioxidant properties; however, its therapeutic effects on established inflammatory dysfunction remain insufficiently characterized. This study investigates the effects of resveratrol on LPS-induced keratinocyte dysfunction and compares them with those of boric acid (BA) under inflammatory conditions.

Methods: Human HaCaT keratinocytes were exposed to 10 μg/mL LPS to establish an inflammatory microenvironment. Following LPS pretreatment, the cells were treated with resveratrol (2, 5, or 10 …

Pgcc-Derived Daughter Cells Are Associated With Aggressive Phenotypes In Gastric Cancer​, Özlem Türksoy Terzi̇oğlu

Turkish Journal of Biology

Background/aim: Polyploid giant cancer cells (PGCCs) have been implicated in tumor recurrence, therapeutic resistance, and cellular plasticity; however, the biological properties of PGCC-derived daughter cells (PGCC-DCs) in gastric cancer remain poorly understood. The present study aimed to evaluate the molecular and functional characteristics of these progeny cells in a gastric cancer model.

Methods: The PGCCs were induced in HGC-27 gastric cancer cells using cobalt(II) chlorideCoCl2-mediated hypoxic stress and enriched by size-based filtration. The PGCC-DCs were isolated through single-cell culture and characterized using molecular and functional assays. Clinical assessments of the cellular parameters were conducted by comparing the PGCC-DCs with parental …

Astaxanthin Elicits A Shared Transcriptional Core And Divergent Cell-Type-Specific Responses In Mcf-7 Breast And Ovcar-3 Ovarian Carcinoma Cells, Duygu Aygüneş Jafari

Turkish Journal of Biology

Background/aim: Astaxanthin, a marine carotenoid, shows antiproliferative activity across cancer models, but its reported mechanisms vary widely by cell type and comparative studies with a common protocol are scarce. This study compared MCF-7 breast (estrogen/ progesterone receptor-positive; wild-type TP53) and OVCAR-3 ovarian carcinoma (high-grade serous; homozygous TP53 R248Q) cells after astaxanthin treatment at cell-line-specific IC50 concentrations.

Materials and methods: Cytotoxicity was measured by WST-1, apoptosis by annexin V/propidium iodide flow cytometry, and 43 cancer-associated genes by a pathway-focused RT-qPCR array (n = 3). Relative expression was calculated by comparative ΔΔCt method with ACTB as the reference gene.

Results: At 72 …

Genetic Inheritance Of Leaf Rolling As An Adaptive Trait For Fog Capture And Drought Tolerance In Wheat, Sabah Merrium, Zulfiqar Ali, Latifa Alhusnain, Muneera D.F. Alkahtani, Sadia Hakeem, Sajid Fiaz, Muhammad Ali Sher, Kotb A. Attia, Seung Hwan Yang, Muhammad Abu Bakar Saddique, Muhammad Hammad Nadeem Tahir

Turkish Journal of Agriculture and Forestry

Wheat is a primary source of sustenance for around 2 billion people worldwide; however, its production is threatened by the water scarcity associated with climate change. In the search for climate-smart wheat varieties, atmospheric moisture in the form of fog and dew is gaining attention as a sustainable, self-irrigating water source for crops. Leaf rolling (LR) is a well-known adaptive trait under water deficit conditions that supports fog moisture capture in wheat; however, little is known about its genetic potential and inheritance pattern, particularly given its high environmental influence. This study assesses the genetic heritability, combining ability, and diversity of …

Valorization Of Buttermilk As A Functional Ingredient In Yogurt Soup: Effects On Physicochemical Properties, Aroma Profile, Amino Acid Composition, And Bioactivities, Emi̇ne Maci̇t, Fatma Zehra Özyilmaz

Turkish Journal of Agriculture and Forestry

​In this study, the feasibility of using buttermilk as a functional ingredient in yogurt soup, a traditional fermented dairy product, was investigated with the aim of valorizing dairy industry by-products. Soup samples prepared with different buttermilk ratios (0%, 25%, 50%, 75%, and 100%) were evaluated for their physicochemical and sensory properties, aroma and amino acid profiles, antioxidant capacity, and antidiabetic activity. The incorporation of buttermilk resulted in statistically significant differences in total solids, ash, and titratable acidity (p < 0.01 and p < 0.05), while no significant changes were observed in fat, protein, or pH values. Increasing buttermilk levels led to higher L* and b* values and lower a* values. Sensory analysis showed that flavor scores increased with buttermilk content, with the highest score observed in the sample containing 100% buttermilk (T5). In the control sample, hexanoic acid, benzoic acid, acetic acid, methyl salicylate, and several ketones were identified as dominant aroma compounds, whereas buttermilk-enriched samples were characterized mainly by hexanoic acid, acetic acid, butanoic acid, ethyl acetate, higher alcohols, and ethanol. Increasing buttermilk content resulted in a higher proportion of alcohols and a reduction in acids, ketones, and aldehydes. Samples with higher buttermilk levels exhibited increased essential amino acid content, while functional amino acids such as γ-aminobutyric acid, β-aminoisobutyric acid, ethanolamine, proline, and alanine reached their highest levels in the T5 sample. The T5 sample showed a DPPH radical scavenging activity of 5.98%, whereas the highest α-amylase inhibition was observed in the control sample. Overall, the results indicate that buttermilk can be effectively used as a functional ingredient in yogurt soup formulations, improving nutritional quality and sensory characteristics.

Tuber Yield Amplification In Dahlia Variabilis L. Under Humic Acid And Fertilizer Combinations, Kedar Mahadev Gheware, Nomita Laishram, Arvinder Singh, Sarabdeep Kour, Sourav Sharma, Aytan Samadova, Melekber Sülüşoğlu Durul, Hali̇l İbrahi̇m Tuzlaci

Turkish Journal of Agriculture and Forestry

Dahlia variabilis L. is a valued tuberous ornamental crop grown worldwide for its attractive flowers. Optimizing nutrient management is crucial for maximizing dahlia growth and tuber yield. In this field study, we evaluated the combined effects of humic acid (HA) and chemical fertilizers on the tuber production of Dahlia variabilis L. A factorial randomized complete block design was used with treatments combining three fertilizer levels (100%, 75%, and 50% of recommended NPK dose) and multiple HA treatments. HA was applied as a soil amendment and foliar spray in combination with inorganic NPK fertilizer. Results showed that integrating HA with reduced …

Bioactive Compounds In Fruits Of Newly Introduced Sweet Cherry Cultivars In Herzegovina, Jasmina Aliman, Mirjana Radović, Ahmed Džubur, Jasna Hasanbegović, Dženan Vukotić, Aleksandra Šupljeglav Jukić, Senad Murtić, Mihajlo Lizdek

Turkish Journal of Agriculture and Forestry

This study evaluated the biochemical characteristics and bioactive compounds of 3 newly introduced Italian sweet cherry cultivars (Sweet Valina, Sweet Stephany, and Sweet Gabriel) grown under the agroecological conditions of Herzegovina (Mostar and Trebinje). The analysis included total soluble solids, total acidity, sweetness index, total phenolic contents, total flavonoid contents, and antioxidant capacity in fruit skin and flesh. Significant differences were observed among cultivars, locations, and their interactions for most analyzed parameters. Fruits from Trebinje generally exhibited higher antioxidant capacity, total phenolic contents in the skin, soluble solids contents, and sweetness index values. Sweet Valina, particularly at the Trebinje location, …

Retraction Notice To “Characterization Of Tfiie-Regulated Genes By Transcriptome Analysis” [Turkish Journal Of Biology, Volume 48, Issue 6, Pages 442–455,Https://Doi.Org/10.55730/1300-0152.2718], Turkish Journal Of Biology

Turkish Journal of Biology

This article has been retracted.

Following concerns raised after publication, the matter was referred to the TÜBİTAK Committee on Research and Publication Ethics (AYEK) for investigation. An Expression of Concern was published while the investigation was ongoing; it was published in the Turkish Journal of Biology, Volume 49, Issue 3, https://journals.tubitak.gov.tr/biology/vol49/iss3/11/.

The investigation has now been concluded. Based on the findings, the project idea and research design underlying the study were used without appropriate attribution or permission. The investigation also determined that a researcher who had contributed to the intellectual foundation of the work—including the development of the …

Characteristics Of Immersion Freezing Ice Nucleating Particles During Dust Season In Beijing, Ke Cao, Manni Chen, Zhaolong Wu, Angnuo Tian, Yangze Ren, Kai Bi, Ping Tian, Qinghong Zhang, Huiwen Xue

Michigan Tech Publications

Atmospheric dust is a primary source of ice nucleating particles (INPs), yet their concentrations at temperatures warmer than −20°C are not fully characterized during Asian dust events. This study uses a membrane filtering method to collect aerosol samples and a droplet freezing method to measure daily immersion-mode INP concentrations in Beijing during the dust season throughout March 2022. Daily aerosol samples are categorized into low, moderate, and heavy dust conditions using volume depolarization ratios from a Micro Pulse Lidar (MPL). Observed INP spectra exhibit a day-to-day variability of up to two orders of magnitude at a given temperature. The INP …

Molecular Evidence For The Atmospheric Transformation Of Trash Burning Aerosol Into Organonitrate- And Organosulfate-Rich Haze: A Case Study From The Eastern Indo-Gangetic Plain, Amna Ijaz, Susan Mathai, Zezhen Cheng, Simeon Schum, Nurun Nahar Lata, William Kew, Claudio Mazzoleni, Lynn Mazzoleni, Swarup China

Michigan Tech Publications

Open burning of solid waste is projected to contribute up to 29% of global anthropogenic PM2.5 emissions, yet its role in secondary aerosol formation remains largely absent from current assessments. Using 21-T Fourier transform-ion cyclotron resonance mass spectrometry, we show that fresh trash burning organic aerosol (tbOA) in the Indo-Gangetic plain, specifically West Bengal, India, during wintertime is dominated by more volatile, low-oxygenation CHO species (66% of the formulae), including markers of plastic and biomass combustion. The downwind ambient aerosol in haze was dominated by less volatile, highly oxygenated organonitrates and organosulfates (>85% of the formulae), consistent with substantial …

Artificial Intelligence For Brain Cancer Management: Multimodal Digital Workflows For Diagnosis, Treatment Planning, And Longitudinal Monitoring, Ganesan Saibaba, Olawumi Giwa, Thomas C. Booth, Terezia Kiskova-Simkova, Arban Uka, Florenc Skuka, Bilal Javed, Dário Ferreira, Sandra Ferreira, Jewel Sengupta, Muhammet Karaman, Gabriel F. Calvo, Xinzhong Li, Tatjana Mitrović, Annalisa Occhipinti, Claudio Angione, Nabiha Missaoui, Milana Frenkel-Morgenstern

Research Outputs: 2025-Present

Brain cancers, especially glioblastoma, remain among the deadliest adult cancers, with outcomes largely unchanged despite multimodal treatments. This review summarizes cutting-edge artificial intelligence (AI) and machine learning (ML) advances transforming neuro-oncology in diagnostics, molecular profiling, treatment planning, and monitoring. Key findings show AI-driven radiomics and deep learning (DL) reaching over 90% accuracy in tumour segmentation and grading from MRI and whole-slide images, non-invasive IDH/MGMT prediction through liquid biopsy (LB) analysis, and augmented reality-guided resection that maximizes tumour removal while safeguarding expressive cortex. Treatment planning benefits from hybrid Convolutional Neural Networks (CNN)-Transformer models for immunotherapy stratification and blood-brain barrier penetrant drug …

Ribosomal Biogenesis In Acute Myeloid Leukemia: A Less-Attended Process With Profound Implications For Oncogenesis And Therapeutic Vulnerability, Muhammad-Redha Abdullah-Zawawi, Nadiah Abu, Nurul Syakima Ab Mutalib, Farah Azima Abdul Muttlib, Hafiza Alauddin

Saudi Medical Journal

No abstract provided.

Sinonasal Inverted Papilloma: Demographics, Recurrence Predictors, And Surgical Outcomes — A 10-Year Retrospective Review At A Tertiary Center In Saudi Arabia, Ali J. Asiry, Majed A. Alali, Nasir A. Magboul, Salem A. Alrasheed, Ibraheem M. Alkanhal, Mohammed A. Alabduljabbar, Raid H. Almadi, Abdullah S. Aldughaither, Faisal S. Alfawaz, Ali Majrashi, Saud Alromaih, Ghassan Alokby, Tamadar Al Doheyan

Saudi Medical Journal

Objectives: To characterize the demographic, clinical, and radiological profile of patients with sinonasal inverted papilloma (IP) managed at a tertiary center in Saudi Arabia, to determine recurrence rates in primary versus revision cases, and to identify factors associated with recurrence.
Methods: This retrospective observational study included 59 adult patients with histopathologically confirmed sinonasal inverted papilloma (IP). Demographic, clinical, radiological, and surgical data were extracted from medical records. Tumors were staged using the Krouse system. Patients were stratified into primary or revision cases, and associations with recurrence were evaluated.
Results: Most patients were men (72.9%) and older than 45 (79.7%) years …

Beyond Chronological Age: Performance Status And Clinical Frailty Predict Survival In Saudi Geriatric Lymphoma Patients: A Competing Risk Analysis, Musa Fares Alzahrani, Ghazi S. Alotaibi, Sarah S. Sewaralthahab, Fatima A. Alshalati, Ibrahim N. Alrumaih, Badraa A. Muharib, Kazi Nur Asfina, Saleh Ahmed Alkholaif, Shaden A. Albassam, Saleh Abdullah Aljanah, Shahad A. Al Hemidin, Ahmed Y. Jamal, Fadi S. Alakeel, Walid A. Alkeridy, Farjah H. Algahtani, Aamer Aleem

Saudi Medical Journal

Objective: To evaluate the prognostic impact of performance status, frailty, and treatment intensity on survival outcomes in a geriatric lymphoma cohort using a competing risk framework. In Saudi Arabia, despite a growing aging population, there is a lack of literature detailing frailty or survival dynamics for geriatric lymphoma patients.
Methods: We conducted retrospective cohort study in Tertiary center in Riyadh, Saudi Arabia. Geriatric patients (≥ 60 years) diagnosed with lymphoma during 2011–2024 were analyzed. Baseline demographics, laboratory parameters, pathology, and frailty status were extracted. Survival dynamics were modeled using cumulative incidence functions to isolate lymphoma-related mortality (LRM) from age-related competing …