Digital Commons Network^™

The -Omics Era- Toward A Systems-Level Understanding Of Streptomyces, Zhan Zhou, Jianying Gu, Yi-Ling Du, Yong-Quan Li, Yufeng Wang

Publications and Research

Streptomyces is a group of soil bacteria of medicinal, economic, ecological, and industrial importance. It is renowned for its complex biology in gene regulation, antibiotic production, morphological differentiation, and stress response. In this review, we provide an overview of the recent advances in Streptomyces biology inspired by -omics based high throughput technologies. In this post-genomic era, vast amounts of data have been integrated to provide significant new insights into the fundamental mechanisms of system control and regulation dynamics of Streptomyces.

Proteases In Malaria Parasites - A Phylogenomic Perspective, Hong Cai, Rui Kuang, Jianying Gu, Yufeng Wang

Publications and Research

Malaria continues to be one of the most devastating global health problems due to the high morbidity and mortality it causes in endemic regions. The search for new antimalarial targets is of high priority because of the increasing prevalence of drug resistance in malaria parasites. Malarial proteases constitute a class of promising therapeutic targets as they play important roles in the parasite life cycle and it is possible to design and screen for specific protease inhibitors. In this mini-review, we provide a phylogenomic overview of malarial proteases. An evolutionary perspective on the origin and divergence of these proteases will provide …

Sagp/Ssips 2011 Program, Anthony Preus

The Society for Ancient Greek Philosophy Newsletter

No abstract provided.

Korean Futures: Challenges To U.S. Diplomacy Of North Korean Regime Collapse, Ferial Ara Saeed, James J. Przystup

INSS Strategic Perspectives

There is no shortage of plausible scenarios describing North Korean regime collapse or how the United States and North Korea’s neighbors might respond to such a challenge. Yet comparatively little attention has been paid to the strategic considerations that may shape the responses of the United States, the Republic of Korea (ROK), Japan, China, and Russia to a North Korean crisis. These states are most likely to take action of some kind in the event the North Korean regime collapses. For the ROK (South Korea), North Korean regime collapse presents the opportunity for Korean reunification. For the other states, the …

Review Of The Species Described In Leptostilbus Casey In North America (Coleoptera: Phalacridae: Xanthocomus Guillebeau), Matthew L. Gimmel

Insecta Mundi

The species of Phalacridae (Coleoptera) historically included in Leptostilbus Casey, 1916, are reviewed. Leptostilbus rutilans Casey, 1916, is here designated as the type species of Leptostilbus. The genus Leptostilbus is synonymized with Xanthocomus Guillebeau, 1893, syn. nov., resulting in two new combinations, Xanthocomus concinnus (Casey, 1916) and X. rutilans (Casey, 1916). Lectotypes are here designated for these two species. Acylomus elongatulus (Casey, 1890), comb. nov., formerly placed in Leptostilbus, is excluded from Xanthocomus. A key and illustrations are provided to aid in recognition of the two species of Xanthocomus in North America, and detailed distribution maps are …

Effects Of In Situ Freezing On Soil Net Nitrogen Mineralization And Net Nitrification In Fertilized Grassland Of Northern China, X. Zhang, W. Bai, Frank S. Gilliam, Q. Wang, X. Han, L. Li

Biological Sciences Faculty Research

Effects of soil freezing on nitrogen (N) mineralization have been the subject of increased attention in the ecological literature, though fewer studies have examined N mineralization responses to successive mild freezing, severe freezing and cyclic freeze–thaw events. Even less is known about relationships of responses to soil N status. This study measured soil N mineralization and nitrification in the field along an experimental N gradient in a grassland of northern China during the dormant season (October 2005–April 2006), a period in which freezing naturally occurs. Net N mineralization exhibited great temporal variability, with nitrification being the predominant N transformation process. …

Selenium And Mercury, University Of North Dakota. Energy And Environmental Research Center

EERC Brochures and Fact Sheets

Fact sheet on selenium. Includes information on nutritional benefits, dietary sources, and mitigating the risks of mercury consumption. [This item is an outdated or superseded version and retained for historical purposes only. It may no longer reflect current information, policies, or practices.]

Increased Floral Divergence In Sympatric Monkeyflowers, Dena L. Grossenbacher, Justen B. Whittall

Biology

Sympatric sister species are predicted to have greater divergence in reproductive traits than allopatric sister species, especially if mating system shifts, such as the evolution of self-fertilization, are more likely to originate within the geographic range of the outcrossing ancestor. We present evidence that supports this expectation-sympatric sister species in the monkeyflower genus, Mimulus, exhibit greater divergence in flower size than allopatric sister species. Additionally, we find that sympatric sister species are more likely to have one species with anthers that overtop their stigmas than allopatric sister species, suggesting that the evolution of automatic self-pollination may contribute to this pattern. …

Watching Avatar Through Deleuzian 3d, Desire, Deterritorialization, And Doubling: A Postcolonial Eco-Theological Review, Jea Sophia Oh

Philosophy Faculty Publications

No abstract provided.

University Of South Florida St. Petersburg Student Research Journal, Vol. 1, Issue 1, Article 3 : Modeling A Molecular Dynamic Simulation Of The Stat3 Monomer, Jessica Ruekberg, Demetrios Kiriopoulos, Kevin Moore, Deby L. Cassill, Leon Hardy

USF St. Petersburg Campus Faculty Publications

STAT3, also known as signal transducer and activator of transcription 3, is a DNA transcription enzyme. In mammals including humans, STAT3 regulates the expression of a variety of genes that play a role in embryonic development. Specifically, STAT3 regulates cell division, cell differentiation and cell death (apoptosis). During embryonic development, STAT3 proteins are phosphorylated in a cell's cytoplasm in response to chemical growth factors. Once phosphorylated, STAT3 proteins pair up to form homodimers that act like pliers. STAT3 homodimers are transferred into the cell nucleus, where they bind to DNA to regulate embryonic development. When mutations of the STAT3 gene …

The Mediatization Of War: A Comparison Of The American And German Media Coverage Of The Vietnam And Iraq Wars, Gerd Horten

CUP Faculty Research

The last fifty years have seen the further expansion of the role of media during times of war. Although no longer dominated by large-scale propaganda agencies as during the two world wars, the media nevertheless have become ever more integral to the planning and conduct of wars. This article applies the concept of mediatization in an attempt to capture the ever-increasing role of the media during war times as part of an ongoing and accelerating historical process. It uses a comparative analysis to highlight the commonalities of this process as well as to emphasize national particularities. The article argues that …

Hexapod Herald - Vol. 23, No. 5, September 2011

Hexapod Herald and Other Entomology Department Newsletters

Welcome

Congratulations

Publications

Meet and Off-Campus Student

Grants

Faculty News

Student News

Travel

This N That

Condolences

Implications Of Simultaneity In A Physical Damage Function, Kelly M. Cobourn, Hannah J. Burrack, Rachael E. Goodhue, Jeffrey C. Williams, Frank G. Zalom

Economics Faculty Publications and Presentations

A modeler must often rely on highly simplified representations of complex physical systems when analyzing associated economic issues. Herein, we consider a management problem in which a bioeconomic system exhibits simultaneity in processes governing productivity and damage. In this case, it may benefit the producer to sacrifice productivity to reduce the costs associated with increased damage. We specify empirically a structural damage relationship that explains the biological process by which an invasive species damages a host and estimate the structural model and its reduced form with an exceptional dataset on infestation of olives by the olive fruit fly. We contrast …

The Summer Season: 1 June - 31 July 2011, Richard L. Knight, Dick D. Preston, Phillip D. Casteel, Richard P. Lewis

The Migrant - Tennessee Ornithological Society

No abstract provided.

Enhancing Genome Investigations In The Mosquito Culex Quinquefasciatus Via Bac Library Construction And Characterization, Paul V. Hickner, Becky Debruyn, Diane D. Lovin, Akio Mori, Christopher Saski, David W. Severson

Publications

Background

Culex quinquefasciatus (Say) is a major species in the Culex pipiens complex and an important vector for several human pathogens including West Nile virus and parasitic filarial nematodes causing lymphatic filariasis. It is common throughout tropical and subtropical regions and is among the most geographically widespread mosquito species. Although the complete genome sequence is now available, additional genomic tools are needed to improve the sequence assembly.

Findings

We constructed a bacterial artificial chromosome (BAC) library using the pIndigoBAC536 vector and HindIII partially digested DNA isolated from Cx. quinquefasciatus pupae, Johannesburg strain (NDJ). Insert size was estimated by Not …

Off-Label Promotion Reform: A Legislative Proposal Addressing Vulnerable Patient Drug Access And Limiting Inappropriate Pharmaceutical Marketing, Tim Mackey, Bryan A. Liang

University of Michigan Journal of Law Reform

Off-label promotion occurs when pharmaceutical manufacturers engage in promotion of unapproved or "off-label" uses of their drugs. These off label uses may lack adequate clinical data to substantiate marketing claims, have led to corporate investigations and penalties, and can endanger public health. However there is adequate evidence to suggest that off-label uses are entirely appropriate for some vulnerable patient populations, and that physicians have accepted such uses as standard. Historically, U.S. law has prohibited direct off-label promotion to physicians and patients. However, failed government guidance, industry-based litigation, and the diminished capacity of regulators to police illegal practices have had dire …

Is The Policy Window Open For High-Speed Rail In The United States: A Perspective From The Multiple Streams Model Of Policymaking, Zhenhua Chen

Transportation Law Journal

No abstract provided.

Ternary Solubilities Of Anthracene In Pressurized Binary Water/Ethanol Mixtures At Temperatures Ranging From 393 K To 473 K, W.H. Teoh, R. Mammucari, N.R. Foster

Research Publications (2011 to 2015)

Solubility measurements were conducted for (1-x) water – x ethanol mixtures at mole fractions, x = 0, 0.02, 0.03 and 0.04 of ethanol in pressurized water/ethanol system at 50 bar between 393 K and 473 K. A static equilibrium method was utilized to measure the solubilities of anthracene. Experimental data shows that the addition of a small amount of a volatile co-solvent to an aqueus mixture enhances the solubility of a hydrophobic compound. It was found that the addition of ethanol is much more effective in enhancing the solubility of anthracene at the higher temperatures. At every concentration of ethanol …

Sex Chromosome Mosaicism And Hybrid Speciation Among Tiger Swallowtail Butterflies, Krushnamegh Kunte, Cristina Shea, Matthew Aardema, J. Mark Scriber, Thomas E. Juenger, Lawrence E. Gilbert, Marcus R. Kronforst

Department of Biology Faculty Scholarship and Creative Works

Hybrid speciation, or the formation of a daughter species due to interbreeding between two parental species, is a potentially important means of diversification, because it generates new forms from existing variation. However, factors responsible for the origin and maintenance of hybrid species are largely unknown. Here we show that the North American butterfly Papilio appalachiensis is a hybrid species, with genomic admixture from Papilio glaucus and Papilio canadensis. Papilio appalachiensis has a mosaic phenotype, which is hypothesized to be the result of combining sex-linked traits from P. glaucus and P. canadensis. We show that P. appalachiensis' Z-linked genes associated with …

Robust Cns Regeneration After Complete Spinal Cord Transection Using Aligned Poly-L-Lactic Acid Microfibers, Andres Hurtado, Jared M. Cregg, Han B. Wang, Dane F. Wendell, Martin Oudega, Ryan J. Gilbert, John W. Mcdonald

Chemical and Biochemical Engineering Faculty Research & Creative Works

Following spinal cord injury, axons fail to regenerate without exogenous intervention. In this study we report that aligned microfiber-based grafts foster robust regeneration of vascularized CNS tissue. Film, random, and aligned microfiber-based conduits were grafted into a 3 mm thoracic rat spinal cord gap created by complete transection. Over the course of 4 weeks, microtopography presented by aligned or random poly- l-lactic acid microfibers facilitated infiltration of host tissue, and the initial 3 mm gap was closed by endogenous cell populations. This bulk tissue response was composed of regenerating axons accompanied by morphologically aligned astrocytes. Aligned fibers promoted long distance …

T10c12-Cla Maintains Higher Bone Mineral Density During Aging By Modulating Osteoclastogenesis And Bone Marrow Adiposity, Md M. Rahman, Ganesh V. Halade, Paul J. Williams, Gabriel Fernandes

Internal Medicine Faculty Publications

Conjugated linoleic acid (CLA) has been shown to positively influence calcium and bone metabolism. Earlier, we showed that CLA (equal mixture of c9t11-CLA and t10c12-CLA) could protect age-associated bone loss by modulating inflammatory markers and osteoclastogenesis. Since, c9t11-CLA and t10c12-CLA isomers differentially regulate functional parameters and gene expression in different cell types, we examined the efficacy of individual CLA isomers against age-associated bone loss using 12 months old C57BL/6 female mice fed for 6 months with 10% corn oil (CO), 9.5% CO+0.5% c9t11-CLA, 9.5% CO+0.5% t10c12-CLA or 9.5% CO+0.25% c9t11-CLA+0.25% t10c12-CLA. Mice fed a t10c12-CLA diet maintained a significantly higher …

Reflections On Teaching Chinese Language Films At American Colleges, Haili Kong

Chinese Faculty Works

No abstract provided.

The Genome Of The Extremophile Crucifer Thellungiella Parvula, Maheshi Dassanayake, Dong Ha Oh, Jeffrey S. Haas, Alvaro Hernandez, Hyewon Hong, Shahjahan Ali, Dae Jin Yun, Ray A. Bressan, Jian Kang Zhu, Hans J. Bohnert, John M. Cheeseman

Faculty Publications

Thellungiella parvula is related to Arabidopsis thaliana and is endemic to saline, resource-poor habitats, making it a model for the evolution of plant adaptation to extreme environments. Here we present the draft genome for this extremophile species. Exclusively by next generation sequencing, we obtained the de novo assembled genome in 1,496 gap-free contigs, closely approximating the estimated genome size of 140 Mb. We anchored these contigs to seven pseudo chromosomes without the use of maps. We show that short reads can be assembled to a near-complete chromosome level for a eukaryotic species lacking prior genetic information. The sequence identifies a …

Enhancing Arabidopsis Leaf Growth By Engineering The Brassinosteroid Insensitive1 Receptor Kinase, Man Ho Oh, Jindong Sun, Dong Ha Oh, Raymond E. Zielinski, Steven D. Clouse, Steven C. Huber

Faculty Publications

The BRASSINOSTEROID INSENSITIVE1 (BRI1) receptor kinase has recently been shown to possess tyrosine kinase activity, and preventing autophosphorylation of the tyrosine-831 regulatory site by site-directed mutagenesis enhances shoot growth. In this study, we characterized the increased leaf growth of Arabidopsis (Arabidopsis thaliana) plants expressing BRI1(Y831F)-Flag compared with BRI1-Flag (both driven by the native promoter and expressed in the bri1-5 weak allele background) and provide insights into the possible mechanisms involved. On average, relative leaf growth rate was increased 16% in the Y831F plants (in the bri1-5 background), and the gain of function of the Y831F-directed mutant was dominant in the …

Stat5a Expression In Swiss 3t3 Cells Promotes Adipogenesis In Vivo In An Athymic Mice Model System, William C. Stewart, Lisa A. Pearcy, Z. Elizabeth Floyd, Jacqueline M. Stephens

Faculty Publications

Many studies from our laboratories and others have shown that STAT5 expression and activity are increased during adipogenesis of murine and human adipocytes. Ectopic expression of STAT5A in fibroblasts or preadipocytes can confer or enhance adipogenesis. To determine whether STAT5A also plays a role in adipogenesis in vivo, we injected athymic mice with Swiss 3T3 cells expressing an empty pBABE retrovirus, Swiss cells expressing a pBABE retrovirus-containing STAT5A, or 3T3-F442A preadipocytes. Athymic mice injected with either 3T3-F442A cells or Swiss 3T3 cells expressing STAT5A resulted in fat pad formation at the site of injection. However, mice injected with Swiss cells …

Functional Genomics Of Physiological Plasticity And Local Adaptation In Killifish, Andrew Whitehead, Fernando Galvez, Shujun Zhang, Larissa M. Williams, Marjorie F. Oleksiak

Faculty Publications

Evolutionary solutions to the physiological challenges of life in highly variable habitats can span the continuum from evolution of a cosmopolitan plastic phenotype to the evolution of locally adapted phenotypes. Killifish (Fundulus sp.) have evolved both highly plastic and locally adapted phenotypes within different selective contexts, providing a comparative system in which to explore the genomic underpinnings of physiological plasticity and adaptive variation. Importantly, extensive variation exists among populations and species for tolerance to a variety of stressors, and we exploit this variation in comparative studies to yield insights into the genomic basis of evolved phenotypic variation. Notably, species of …

Faculty Senate Newsletter, September 2011, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Message from President: It would be fair enough to borrow from Shakespeare and proclaim the long budget crisis, which bodes to run from 2008 until 2013, as the fully nuclear winter of our discontent. Alas for the spirits of sorrow, the perpetual summer of our tropical state leaves us without adequate imagery to describe the gloom that pervades a campus that has been daunted by the people’s penury and demoralized by unaccountable private critics of exposed public servants. As Shakespeare well understood when he analyzed King Richard III, the deformity of the world eventually deforms even the strongest soul. Several …

Calophya Latiforceps, A New Species Of Jumping Plant Lice (Hemiptera: Calophyidae) Associated With Schinus Terebinthifolius (Anacardiaceae) In Brazil, D. Burckhardt, J. P. Cuda, V. Manrique, R. Diaz, W. A. Overholt, D. A. Williams, L. R. Christ, M. D. Vitorino

Faculty Publications

Brazilian peppertree, Schinus terebinthifolius Raddi, is a perennial woody plant native to Brazil, Argentina, and Paraguay that is recognized as one of the most invasive weeds in Florida. A new species of leaflet galling psyllid was discovered attacking Brazilian peppertree in Bahia, Brazil in March 2010. In this paper, a formal morphological description of the new psyllid Calophya latiforceps sp. nov. (Hemiptera: Calophyidae) is presented along with molecular evidence confirming new species designation. This previously unknown natural enemy may have potential as a biological control agent for the Brazilian peppertree. Copyright © 2011 BioOne All rights reserved.

Swosu Fact Book Fall 2011, Denisa Engelman

Fact Books

I am proud to introduce the 20th annual Southwestern Oklahoma State University Fact Book. The Fact Book provides a ready source of information to answer frequently asked questions about the University and its operations. Unless otherwise noted, the information in this Fact Book came from computer-generated reports that

are printed following the tenth class day of each fall semester. Because of student fluctuations during the semester, numbers will not match other published enrollment numbers that may be based on enrollment at the end of a semester.

Portland State Magazine, Portland State University. Office Of University Communications

Portland State Magazine

PSU’s alumni magazine, published 2-3 times a year. In this issue: Research shows that bad bosses can make their employees not just miserable, but actually sick; companies and their busy employees gain new skills through the Professional Development Center; integrity of craftsmanship is defining new ways of doing business in Portland; a vision for campus in the next 25 years; and more.