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The Spinnaker [Vol. 33 No. 69], University Of North Florida

Spinnaker

Student newspaper for the UNF community. Date: September 21, 2011

Structure-Based Development Of Small Molecule Pfkfb3 Inhibitors: A Framework For Potential Cancer Therapeutic Agents Targeting The Warburg Effect, Minsuh Seo, Jeong Do Kim, David Neau, Inder Sehgal, Yong Hwan Lee

Faculty Publications

Cancer cells adopt glycolysis as the major source of metabolic energy production for fast cell growth. The HIF-1-induced PFKFB3 plays a key role in this adaptation by elevating the concentration of Fru-2,6-BP, the most potent glycolysis stimulator. As this metabolic conversion has been suggested to be a hallmark of cancer, PFKFB3 has emerged as a novel target for cancer chemotherapy. Here, we report that a small molecular inhibitor, N4A, was identified as an initial lead compound for PFKFB3 inhibitor with therapeutic potential. In an attempt to improve its potency, we determined the crystal structure of the PFKFB3•N4A complex to 2.4 …

What's New In Orthopaedic Trauma, William M. Ricci, Christopher Mcandrew, David Merriman, Michael J. Gardner

Open Access Publications

No abstract provided.

Daily Eastern News: September 21, 2011, Eastern Illinois University

September

No abstract provided.

Genome Of Mycoplasma Haemofelis, Unraveling Its Strategies For Survival And Persistence, Andrea P. Santos, Ana Ms Guimaraes, Naila C. Do Nascimento, Phillip J. Sanmiguel, Samuel W. Martin, Joanne Messick

Department of Comparative Pathobiology Faculty Publications

Mycoplasma haemofelis is a mycoplasmal pathogen (hemoplasma) that attaches to the host’s erythrocytes. Distributed worldwide, it has a significant impact on the health of cats causing acute disease and, despite treatment, establishing chronic infection. It might also have a role as a zoonotic agent, especially in immunocompromised patients. Whole genome sequencing and analyses of M. haemofelis strain Ohio2 was undertaken as a step toward understanding its survival and persistence. Metabolic pathways are reduced, relying on the host to supply many of the nutrients and metabolites needed for survival. M. haemofelis must import glucose for ATP generation and ribose derivates for …

Composition Of Suspended And Benthic Particulate Matter In The Tidal Freshwater James River, Anne Schlegel

Theses and Dissertations

Investigating linkages between the compositions of suspended (seston) and benthic particulate matter is important to the understanding of organic matter (OM) cycling and nutrient retention in aquatic systems. We compared the quantity and quality of the truly suspended (TS) and settleable (SB) fractions of seston as well as benthic particulate matter in the tidal freshwater James River, Virginia. The mass of seston and OM was consistently higher in the TS fraction compared to the SB fraction. OM was preferentially retained in the TS fraction relative to seston. The proportional contribution of OM constituents (chlorophyll a, particulate organic carbon and nitrogen) …

Earth Jurisprudence And Lockean Theory: Rethinking The American Perception Of Private Property, Traci Lynne Timmons

Environmental and Earth Law Journal (EELJ)

Earth Jurisprudence and Lockean Theory

Abstract by Traci Lynne Timmons

Thomas Berry, father of the Earth Jurisprudence movement, called for re-examining human-Earth relations. Earth Jurisprudence aspires to promote a greater respect for nature and all living things on Earth, aiming to intertwine Earth’s natural law with the body of law that governs humanity. This paper explores Earth Jurisprudence as an alternative to the property regime in the United States. It examines the fundamental principles of property ownership, frequently attributed to the philosophy of John Locke, but digs deeper into these “Lockean” roots to reveal important caveats to Locke’s general principles …

A Strawberry Knox Gene Regulates Leaf, Flower And Meristem Architecture, Mithu Chatterjee, Claudia L. Bermudez-Lozano, Maureen A. Clancy, Thomas M. Davis, Kevin M. Folta

Biological Sciences

The KNOTTED-LIKE HOMEODOMAIN (KNOX) genes play a central role in maintenance of the shoot apical meristem. They also contribute to the morphology of simple and compound leaves. In this report we characterize the FaKNOX1 gene from strawberry (Fragaria spp.) and demonstrate its function in trasgenic plants. The FaKNOX1 cDNA was isolated from a cultivated strawberry (F.×ananassa) flower EST library. The sequence is most similar to Class I KNOX genes, and was mapped to linkage group VI of the diploid strawberry genome. Unlike most KNOX genes studied, steady-state transcript levels were highest in flowers and fruits. Transcripts were also detected in …

The Good 5 Cent Cigar (9/20/2011), University Of Rhode Island

The Good 5 Cent Cigar (Student Newspaper Archives)

This is a digitized, downloadable version of the University of Rhode Island school newspaper.

Combining Tower Mixing Ratio And Community Model Data To Estimate Regional-Scale Net Ecosystem Carbon Exchange By Boundary Layer Inversion Over 4 Flux Towers In The U.S.A., Xuerui Dang, Chun-Ta Lai, David Y. Hollinger, Andrew J. Schauer, Jingfeng Xiao, J. William Munger, Clenton Owensby, James R. Ehleringer

All Materials

We evaluated an idealized boundary layer (BL) model with simple parameterizations using vertical transport information from community model outputs (NCAR/NCEP Reanalysis and ECMWF Interim Analysis) to estimate regional-scale net CO2 fluxes from 2002 to 2007 at three forest and one grassland flux sites in the United States. The BL modeling approach builds on a mixed-layer model to infer monthly average net CO2 fluxes using high-precision mixing ratio measurements taken on flux towers. We compared BL model net ecosystem exchange (NEE) with estimates from two independent approaches. First, we compared modeled NEE with tower eddy covariance measurements. The second approach (EC-MOD) …

Landscapes Of Wealth & Desire, Ryan B. Anderson

Faculty Publications

This paper explores the historical background to a proposed study of political disputes over the value of large-scale tourism development in Baja California Sur. The paper starts with a review of anthropological discussions of value — focusing on the work of Kluckhohn, Graeber, Elyachar and Appadurai. The aim is to use an anthropological approach to value to place current conflicts over land and resources arising from recent developments within a historical perspective. The paper then investigates how actors in different time periods have contributed to collective and often contradictory constructions of the area as a place of subsistence, adventure, possibilities, …

Rna Oxidation Adducts 8-Ohg And 8-Oha Change With Aβ42 Levels In Late-Stage Alzheimer's Disease, Adam M. Weidner, Melissa A. Bradley, Tina L. Beckett, Dana M. Niedowicz, Amy L.S. Dowling, Sergey V. Matveev, Harry Levine, Mark A. Lovell, M. Paul Murphy

Sanders-Brown Center on Aging Faculty Publications

While research supports amyloid-β (Aβ) as the etiologic agent of Alzheimer's disease (AD), the mechanism of action remains unclear. Evidence indicates that adducts of RNA caused by oxidation also represent an early phenomenon in AD. It is currently unknown what type of influence these two observations have on each other, if any. We quantified five RNA adducts by gas chromatography/mass spectroscopy across five brain regions from AD cases and age-matched controls. We then used a reductive directed analysis to compare the RNA adducts to common indices of AD neuropathology and various pools of Aβ. Using data from four disease-affected brain …

Micrornas And Phylogenomics Resolve The Relationships Of Tardigrada And Suggest That Velvet Worms Are The Sister Group Of Arthropoda, Lahcen I. Campbell, Omar Rota-Stabelli, Gregory D. Edgecombe, Trevor Marchioro, Stuart J. Longhorn, Maximilian J. Telford, Hervé Philippe, Lorena Rebecchi, Kevin J. Peterson, Davide Pisani

Dartmouth Scholarship

Morphological data traditionally group Tardigrada (water bears), Onychophora (velvet worms), and Arthropoda (e.g., spiders, insects, and their allies) into a monophyletic group of invertebrates with walking appendages known as the Panarthropoda. However, molecular data generally do not support the inclusion of tardigrades within the Panarthropoda, but instead place them closer to Nematoda (roundworms). Here we present results from the analyses of two independent genomic datasets, expressed sequence tags (ESTs) and microRNAs (miRNAs), which congruently resolve the phylogenetic relationships of Tardigrada. Our EST analyses, based on 49,023 amino acid sites from 255 proteins, significantly support a monophyletic Panarthropoda including Tardigrada and …

Report: The Illinois State University Faculty-Staff Newsletter, September 20, 2011, Illinois State University

Illinois State University Report (1966-2012)

Illinois State University bi-weekly employee newsletter.

The Sun Star, Vol. 31 No. 03 (September 20, 2011), N/A N/A

Sun Star

No abstract provided.

Targeted Enrichment Of Ancient Pathogens Yielding The Ppcp1 Plasmid Of Yersinia Pestis From Victims Of The Black Death, Verena J. Schuenemann, Kristen Bos, Sharon Dewitte, Hendrik N. Poinar, Sarah Schmedes, Joslyn Jamieson, Alissa Mittnik, Stephen Forrest, Brian K. Coombes, James W. Wood, David J.D. Earn, William White, Johannes Krause, Hendrik N. Poinar

Faculty Publications

Although investigations of medieval plague victims have identified Yersinia pestis as the putative etiologic agent of the pandemic, methodological limitations have prevented large-scale genomic investigations to evaluate changes in the pathogen's virulence over time. We screened over 100 skeletal remains from Black Death victims of the East Smithfield mass burial site (1348–1350, London, England). Recent methods of DNA enrichment coupled with high-throughput DNA sequencing subsequently permitted reconstruction of ten full human mitochondrial genomes (16 kb each) and the full pPCP1 (9.6 kb) virulence-associated plasmid at high coverage. Comparisons of molecular damage profiles between endogenous human and Y. pestis DNA confirmed …

The Current Volume 22 : Issue 5, Nova Southeastern University

Student Newspapers

No abstract provided.

Miscanthus 3 Giganteus Productivity: The Effects Of Management In Different Environments, Matt Maughan, German Bollero, D.K. Lee, Robert Darmody, Stacy Bonos, Laura Cortese, James Murphy, Roch E. Gaussoin, Matthew Sousek, David Williams, Linda Williams, Fernando Miguez, Thomas Voigt

Department of Agronomy and Horticulture: Faculty Publications

Miscanthus 9 giganteus is a C4 perennial grass that shows great potential as a high-yielding biomass crop. Scant research has been published that reports M. 9 giganteus growth and biomass yields in different environments in the United States. This study investigated the establishment success, plant growth, and dry biomass yield of M. 9 giganteus during its first three seasons at four locations (Urbana, IL; Lexington, KY; Mead, NE; Adelphia, NJ) in the United States. Three nitrogen rates (0, 60, and 120 kg ha -1) were applied at each location each year. Good survival of M. 9 giganteus during its first …

Aggression And Welfare In A Common Aquarium Fish, The Midas Cichlid, Ronald G. Oldfield

Faculty Scholarship

Many species of fishes are aggressive when placed in small aquaria. Aggression can negatively affect the welfare of those individuals toward whom it is directed. Animals may behave aggressively in order to defend resources such as food, shelter, mates, and offspring. The decision to defend depends on the distribution of resources and on ecological factors such as number of competitors, amount of available space, and amount of habitat complexity. This study tested the effects of these factors on aggression in a common aquarium fish, the Midas cichlid (Amphilophus citrinellus). The study found that time spent behaving aggressively was not associated …

Highly Variable Recessive Lthal Or Nearly Lethal Mutation Rates During Germ-Line Development Of Male Drosophila Melanogaster, Jian-Jun Gao, Xue-Rong Pan, Jing Hu, Li Ma, Jian-Min Wu, Ye-Lin Shao, Sara A Barton, Ronny C Woodruff, Ya-Ping Zhang, Yun-Xin Fu

Faculty, Staff and Student Publications

Each cell of higher organism adults is derived from a fertilized egg through a series of divisions, during which mutations can occur. Both the rate and timing of mutations can have profound impacts on both the individual and the population, because mutations that occur at early cell divisions will affect more tissues and are more likely to be transferred to the next generation. Using large-scale multigeneration screening experiments for recessive lethal or nearly lethal mutations of Drosophila melanogaster and recently developed statistical analysis, we show for male D. melanogaster that (i) mutation rates (for recessive lethal or nearly lethal) are …

Volume 109, Number 4 - Tuesday, September 20, 2011, Saint Mary's College Of California

The Collegian

No abstract provided.

A Growing Debate Over The Rights Of Posthumously Conceived Children: Part Two In A Two-Part Series Of Columns, Joanna L. Grossman

Hofstra Law Faculty Scholarship

In Beeler v. Astrue, a recent case that I discussed at length in Part One of this series of columns, the U.S. Court of Appeals for the Eighth Circuit ruled that a child known as B.E.B. was not the legal daughter of Bruce Beeler, whose sperm had been used to impregnate his widow about a year after he died.

The paternity issue arose because B.E.B.’s mother, Patti Beeler, had applied to the Social Security Administration on B.E.B.’s behalf for surviving-child benefits. The appellate court ruled that a survivor is a “child” of a wage-earning decedent only if intestacy law …

The Wilderness Myth: How The Failure Of The American National Park Model Threatens The Survival Of The Iyaelima Tribe And The Bonobo Chimpanzee, Mark Hopson

Environmental and Earth Law Journal (EELJ)

The Wilderness Myth

Abstract by Mark Hopson

Contrary to popular opinion, and the vast majority of legal scholarship on the subject, the traditional American model for a national park is scientifically and logically unsound. Further, this model has been adopted at a terrible social cost to the indigenous tribes who lived on the land that became national parks. Every government that has chosen to implement the American national park model has done so at the expense of indigenous people.

This article chronicles the creation of the world’s first national parks, Yosemite and Yellowstone, and the legal battles involved. The article …

Book Review: The Soft Voice Of Reason, Emanuel E. Garcia, Md

Jefferson Journal of Psychiatry

FREUD AS AN EXPERT WITNESS

K. R. Eissler

Madison, Connecticut, International Universities Press 1986, 449 pages.

The Chanticleer, 2011-09-19, Coastal Carolina University

The Chanticleer Student Newspaper

The editorially independent student produced weekly newspaper of Coastal Carolina University.

Lanthorn, Vol. 46, No. 08, September 19, 2011, Grand Valley State University

Volume 46, July 14, 2011 - June 18, 2012

Lanthorn is Grand Valley State's student newspaper, published from 1968 to the present.

Spartan Daily September 19, 2011, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 137, Issue 11

The Statesman, V. 55, I. 03, Stony Brook University

Stony Brook Statesman-Sucolian

v. 55, i. 03

Current, September 19, 2011, University Of Missouri-St. Louis

Current (2010s)

No abstract provided.

2011-2012 Us Army War College Key Strategic Issues List, Antulio J. Echevarria Ii

Articles & Editorials

No abstract provided.