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2011

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Infrared Surface Plasmons On Heavily Doped Silicon, Monas Shahsad, Gautam Medhi, Robert E. Peale, Walter R. Buchwald, Justin W. Cleary, Richard Soref, Glenn D. Boreman, Oliver Edwards Jan 2011

Infrared Surface Plasmons On Heavily Doped Silicon, Monas Shahsad, Gautam Medhi, Robert E. Peale, Walter R. Buchwald, Justin W. Cleary, Richard Soref, Glenn D. Boreman, Oliver Edwards

Faculty Bibliography 2010s

Conductors with infrared plasma frequencies are potentially useful hosts of surface plasmon polaritons (SPP) with sub-wavelength mode confinement for sensing applications. A challenge is to identify such a conductor that also has sharp SPP excitation resonances and the capability to be functionalized for biosensor applications. In this paper we present experimental and theoretical investigations of IR SPPs on doped silicon and their excitation resonances on doped-silicon gratings. The measured complex permittivity spectra for p-type silicon with carrier concentration 6 x 10(19) and 1 x 10(20) cm(-3) show that these materials should support SPPs beyond 11 and 6 mu m wavelengths, …

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Inactivation And Reactivation Of The Mitochondrial Alpha-Ketoglutarate Dehydrogenase Complex, Qingli Shi, Hui Xu, Haiqiang Yu, Nawei Zhang, Yaozu Ye, Alvaro G. Estevez, Haiteng Deng, Gary E. Gibson Jan 2011

Inactivation And Reactivation Of The Mitochondrial Alpha-Ketoglutarate Dehydrogenase Complex, Qingli Shi, Hui Xu, Haiqiang Yu, Nawei Zhang, Yaozu Ye, Alvaro G. Estevez, Haiteng Deng, Gary E. Gibson

Faculty Bibliography 2010s

Reduced brain metabolism is an invariant feature of Alzheimer Disease (AD) that is highly correlated to the decline in brain functions. Decreased activities of key tricarboxylic acid cycle (TCA) cycle enzymes may underlie this abnormality and are highly correlated to the clinical state of the patient. The activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), an arguably rate-limiting enzyme of the TCA cycle, declines with AD, but the mechanism of inactivation and whether it can be reversed remains unknown. KGDHC consists of multiple copies of three subunits. KGDHC is sensitive to oxidative stress, which is pervasive in AD brain. The present …

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A Novel Three-Protein Complex Regulates In Vitro Vtv-Golgi Fusion, S. A. Siddiqi, E. Nafi-Valencia, S. Siddiqi, A. Rahim Jan 2011

A Novel Three-Protein Complex Regulates In Vitro Vtv-Golgi Fusion, S. A. Siddiqi, E. Nafi-Valencia, S. Siddiqi, A. Rahim

Faculty Bibliography 2010s

No abstract provided.

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A Selenium-Dependent Xanthine Dehydrogenase Triggers Biofilm Proliferation In Enterococcus Faecalis Through Oxidant Production, Milan Srivastava, Chris Mallard, Theresa Barke, Lynn E. Hancock, William T. Self Jan 2011

A Selenium-Dependent Xanthine Dehydrogenase Triggers Biofilm Proliferation In Enterococcus Faecalis Through Oxidant Production, Milan Srivastava, Chris Mallard, Theresa Barke, Lynn E. Hancock, William T. Self

Faculty Bibliography 2010s

Selenium has been shown to be present as a labile cofactor in a small class of molybdenum hydroxylase enzymes in several species of clostridia that specialize in the fermentation of purines and pyrimidines. This labile cofactor is poorly understood, yet recent bioinformatic studies have suggested that Enterococcus faecalis could serve as a model system to better understand the way in which this enzyme cofactor is built and the role of these metalloenzymes in the physiology of the organism. An mRNA that encodes a predicted selenium-dependent molybdenum hydroxylase (SDMH) has also been shown to be specifically increased during the transition from …

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A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication And Unfolding/Translocation Of The Cholera Toxin A1 Subunit, Michael Taylor, Tuhina Banerjee, Fernando Navarro-Garcia, Jazmin Huerta, Shane Massey, Mansfield Burlingame, Abhay H. Pande, Suren A. Tatulian, Ken Teter Jan 2011

A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication And Unfolding/Translocation Of The Cholera Toxin A1 Subunit, Michael Taylor, Tuhina Banerjee, Fernando Navarro-Garcia, Jazmin Huerta, Shane Massey, Mansfield Burlingame, Abhay H. Pande, Suren A. Tatulian, Ken Teter

Faculty Bibliography 2010s

Cholera toxin (CT) travels as an intact AB(5) protein toxin from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin. Translocation of CTA1 from the ER to the cytosol is then facilitated by the quality control mechanism of ER-associated degradation (ERAD). Thermal instability in the isolated CTA1 subunit generates an unfolded toxin conformation that acts as the trigger for ERAD-mediated translocation to the cytosol. In this work, we show by circular dichroism and fluorescence spectroscopy that exposure to 4-phenylbutyric acid (PBA) inhibited the …

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Protein-Disulfide Isomerase Displaces The Cholera Toxin A1 Subunit From The Holotoxin Without Unfolding The A1 Subunit, Michael Taylor, Tuhina Banerjee, Supriyo Ray, Suren A. Tatulian, Ken Teter Jan 2011

Protein-Disulfide Isomerase Displaces The Cholera Toxin A1 Subunit From The Holotoxin Without Unfolding The A1 Subunit, Michael Taylor, Tuhina Banerjee, Supriyo Ray, Suren A. Tatulian, Ken Teter

Faculty Bibliography 2010s

Protein-disulfide isomerase (PDI) has been proposed to exhibit an "unfoldase" activity against the catalytic A1 subunit of cholera toxin (CT). Unfolding of the CTA1 subunit is thought to displace it from the CT holotoxin and to prepare it for translocation to the cytosol. To date, the unfoldase activity of PDI has not been demonstrated for any substrate other than CTA1. An alternative explanation for the putative unfoldase activity of PDI has been suggested by recent structural studies demonstrating that CTA1 will unfold spontaneously upon its separation from the holotoxin at physiological temperature. Thus, PDI may simply dislodge CTA1 from the …

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Interpretations Of Pre-Hispanic Ritual Violence At Tucume, Peru, From Cut Mark Analysis, J. Marla Toyne Jan 2011

Interpretations Of Pre-Hispanic Ritual Violence At Tucume, Peru, From Cut Mark Analysis, J. Marla Toyne

Faculty Bibliography 2010s

Archaeological residues of ritual are often ephemeral, and reconstructing the dynamics of performed actions that create deposits can be difficult. Rituals associated with the dead are common across many cultures since all human,groups have specific means of disposing of corpses. Evidence of peri- and postmortem manipulation of human remains,such as cutting. dismemberment, or disarticulation can provide details of the sequence of actions performed related to the circumstances surrounding death and the possible social meaning of those behaviors. Cur marks observed on the upper chest and throat of 93 percent of 117 children and men found interred at the Temple oldie …

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Regulation Of The Oncoprotein Klf8 By A Switch Between Acetylation And Sumoylation, Alison M. Urvalek, Heng Lu, Xianhui Wang, Tianshu Li, Lin Yu, Jinghua Zhu, Qishan Lin, Jihe Zhao Jan 2011

Regulation Of The Oncoprotein Klf8 By A Switch Between Acetylation And Sumoylation, Alison M. Urvalek, Heng Lu, Xianhui Wang, Tianshu Li, Lin Yu, Jinghua Zhu, Qishan Lin, Jihe Zhao

Faculty Bibliography 2010s

KLF8 regulates target genes by recruiting the p300 and PCAF co-activators via glutamines (Q) 118 and 248, the CtBP co-repressor to 86PVDLS90 or SUMO to lysine (K) 67. Here we examined how these interactions coordinate to regulate KLF8 transactivity. Mass spectrometry and immunoprecipitations determined that p300 and/or PCAF promoted KLF8 acetylation at K67, K93, and K95 and this acetylation was abolished in lysine-to-arginine (R) mutants. Treatment with HDAC inhibitors or expression of co-activators inhibited sumoylation at K67. K93R or K95R mutation exerted high levels of sumoylation while the acetylation mimetic mutations K93Q and K95Q blocked the sumoylation. Interestingly, CtBP promoted …

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Professional School Counselors' Perspectives On The Effects Of Military Parental Deployment On School Aged Children And Adolescents, Cheryl G. Mccloud Jan 2011

Professional School Counselors' Perspectives On The Effects Of Military Parental Deployment On School Aged Children And Adolescents, Cheryl G. Mccloud

Electronic Theses and Dissertations

This qualitative study used an exploratory phenomenological approach to examine professional school counselors‘ perspectives on the effects of military parental deployment on school aged children and adolescents. The voices of school counselors who work with military connected children are absent from the literature. The research site was a professional counseling conference in Germany in the fall of 2010. Participants consisted of 12 professional school counselors who work with school-aged children and adolescents who have experienced parental military deployment. Participants adopted pseudonyms though several indicated an affiliation with Department of Defense Dependent Schools (DODDS) and therefore offered their unique perspectives as …

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Electromagnetic Propagation Anomalies In Waveguiding Structures And Scattering Systems, Alessandro Salandrino Jan 2011

Electromagnetic Propagation Anomalies In Waveguiding Structures And Scattering Systems, Alessandro Salandrino

Electronic Theses and Dissertations

The effects related to diffraction and interference are ubiquitous in phenomena involving electromagnetic wave propagation, and are accurately predicted and described within the framework of classical electrodynamics. In the vast majority of the cases the qualitative features of the evolution of a propagating wave can be inferred even without detailed calculations. A field distribution will spread upon propagation, will accumulate phase along the direction of power flow, will exert mechanical forces upon scattering objects in the direction of propagation etc. When such predictions fail, counterintuitive effects and new functionalities can be engineered. In this work a series of exceptional cases …

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Stable Carbon And Nitrogen Isotope Analyses Of Subfossil Rats From Liang Bua (Flores, Indonesia), Kelly C. Anderson Jan 2011

Stable Carbon And Nitrogen Isotope Analyses Of Subfossil Rats From Liang Bua (Flores, Indonesia), Kelly C. Anderson

Electronic Theses and Dissertations

This research study investigated the level of bone collagen preservation of rat femora from Liang Bua cave on the island of Flores, Indonesia, as well as conducted carbon and nitrogen stable isotopic analyses on well preserved samples. Although Flores is located in a hot intermediate tropical zone and the burial environment of the bone samples within the cave is considered less than optimal for collagen preservation, significant preservation of the bone collagen was found. Collagen yields, C:N ratio and carbon and nitrogen concentrations were investigated. However, this research study argues that carbon and nitrogen concentrations are an appropriate means to …

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Birth Of A Mother, Ashley Rae Curran Jan 2011

Birth Of A Mother, Ashley Rae Curran

Electronic Theses and Dissertations

Birth of a Mother is a memoir that tells the story of how my unplanned pregnancy helps me to transform from a damaged adolescent into an empowered mother. Using a first person, present tense narrative, I relive the nine months leading up to the unmedicated home birth of my first child, exploring the conflicts I faced over my obesity, over having no job and no place to call home, and over developing a relationship with a man who was not the baby's father. Weaving in past tense vignettes, I attempt to show how I prepared myself for impending motherhood by …

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A Paleopathological Assessment Of Osteoarthritis In The Lower Appendicular Joints Of Individuals From The Kellis 2 Cemetery In The Dakhleh Oasis, Egypt, Joshua B. Robin Jan 2011

A Paleopathological Assessment Of Osteoarthritis In The Lower Appendicular Joints Of Individuals From The Kellis 2 Cemetery In The Dakhleh Oasis, Egypt, Joshua B. Robin

Electronic Theses and Dissertations

Osteoarthritis (OA) is a degenerative pathological condition of the appendicular joints which affects the cartilage and underlying bone. OA is relatively common in both the archaeological and clinical context, and a significant amount of research has been conducted on this osteological condition. The purpose of this thesis is to assess the incidence, demographic prevalence, and general severity of hip and knee OA in a Roman-Christian period (50 A.D – 450 A.D) population sample from the Dakhleh Oasis, Egypt. The bioarchaeological sample originates from the Kellis 2 cemetery which is associated with the ancient town of Kellis. The town of Kellis …

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Gender Composition Of Online Technical Communication Collaborations, Erika A. Wardell Jan 2011

Gender Composition Of Online Technical Communication Collaborations, Erika A. Wardell

Electronic Theses and Dissertations

Online collaborations are more prevalent in society due to electronic communication allowing students and professionals to communicate with each other, without needing to spend time or money traveling. The lack of visual cues in electronic communication means writing styles primarily set the tone of a message. A group member‟s gender can affect his or her writing style and what he or she assumes about the message. The differing writing styles and potential gender bias can cause misunderstandings, which delay projects and sometimes lead to ostracizing a group member. The gender composition of an online collaboration, therefore, can have a positive …

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Peak Performance Training, Matthew Gabriel Hallett Jan 2011

Peak Performance Training, Matthew Gabriel Hallett

Electronic Theses and Dissertations

Peak performance is defined as an “episode of superior functioning” where an individual performs up to (and sometimes exceeds) their full potential (Privette, 1983, p. 1361). Most individuals do not consistently experience episodes of peak performance. After accounting for biological factors, motivation, and external constraints, the inability to achieve peak performance consistently is due to the challenge of successfully selecting and accessing knowledge and skills on demand while under pressure (Brown, 2009). This thesis describes the psychology of peak performance and skill training for peak performance. A peak performance training program is designed specifically for business professionals. The program was …

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The Collector As Arbiter Of Art A Phenomenological Investigation Of Collectors' Critical Judgment Development And Their Understanding Of Art Toward A Theoretical Model For Appreciation And Criticism In Art Education, Anne C. Grey Jan 2011

The Collector As Arbiter Of Art A Phenomenological Investigation Of Collectors' Critical Judgment Development And Their Understanding Of Art Toward A Theoretical Model For Appreciation And Criticism In Art Education, Anne C. Grey

Electronic Theses and Dissertations

The purpose of this study was to investigate art collectors’ specific method of developing and making critical judgments in the context of their understanding of art. Phenomenological research methods were employed to obtain data through interviews with collectors of Contemporary African American art, Latin American art, and Minimalist and Conceptual art. Based on the findings, collectors’ approaches to critical judgment can be categorized into three areas. First, critical skills are both intuitive and developed over time, through a holistic and aesthetic process set in the art world. Collectors’ edification requires commitment, and intense looking enabling them to see how works …

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Intracavity Laser Absorption Spectroscopy Using Quantum Cascade Laser And Fabry-Perot Interferometer, Gautam Medhi Jan 2011

Intracavity Laser Absorption Spectroscopy Using Quantum Cascade Laser And Fabry-Perot Interferometer, Gautam Medhi

Electronic Theses and Dissertations

Intracavity Laser Absorption Spectroscopy (ICLAS) at IR wavelengths offers an opportunity for spectral sensing of low vapor pressure compounds. We report here an ICLAS system design based on a quantum cascade laser (QCL) at THz (69.9 m) and IR wavelengths (9.38 and 8.1 m) with an open external cavity. The sensitivity of such a system is potentially very high due to extraordinarily long effective optical paths that can be achieved in an active cavity. Sensitivity estimation by numerical solution of the laser rate equations for the THz QCL ICLAS system is determined. Experimental development of the external cavity QCL is …

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Modeling Mass Care Resource Provision Post Hurricane, Tammy Marie Muhs Jan 2011

Modeling Mass Care Resource Provision Post Hurricane, Tammy Marie Muhs

Electronic Theses and Dissertations

Determining the amount of resources needed, specifically food and water, following a hurricane is not a straightforward task. Through this research effort, an estimating tool was developed that takes into account key demographic and evacuation behavioral effects, as well as hurricane storm specifics to estimate the number of meals required for the first fourteen days following a hurricane making landfall in the State of Florida. The Excel based estimating tool was created using data collected from four hurricanes making landfall in Florida during 2004-2005. The underlying model used in the tool is a Regression Decision Tree with predictor variables including …

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Biology, Ecology And Control Of The Invasive Channeled Apple Snail, Pomacea Canaliculata, Christina M. Trexler Jan 2011

Biology, Ecology And Control Of The Invasive Channeled Apple Snail, Pomacea Canaliculata, Christina M. Trexler

Electronic Theses and Dissertations

Invasive species are detrimental to native biotas worldwide. Recently, Florida was invaded by a freshwater snail (Pomacea canaliculata) native to Argentina. This snail is a serious pest of rice crops in Asia, but little is known about its interactions within Florida ecosystems. Possible competitive exclusion of the native congener (P. paludosa) is a concern because it is the almost exclusive prey of the federally endangered Everglades snail kite (Rostrhamus sociabilis). My research consisted of three parts. First, to identify possible methods to control P. canaliculata in the egg stage, I experimentally evaluated the effects of photoperiod, substrate availability, and food …

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Characterization Of Composite Broad Band Absorbing Conjugated Polymer Nanoparticles Using Steady-State, Time-Resolve And Single Particle Spectroscopy, Maxwell Scotland Bonner Jan 2011

Characterization Of Composite Broad Band Absorbing Conjugated Polymer Nanoparticles Using Steady-State, Time-Resolve And Single Particle Spectroscopy, Maxwell Scotland Bonner

Electronic Theses and Dissertations

As the global economy searches for reliable, inexpensive and environmentally friendly renewable energy resources, energy conservation by means of photovoltaics has seen near exponential growth in the last decade. Compared to state-of-the-art inorganic solar cells, organic photovoltaics (OPVs) composed of conjugated polymers are particularly interesting because of their processability, flexibility and the potential for large area devices at a reduced fabrication cost. It has been extensively documented that the interchain and intrachain interactions of conjugated polymers complicate the fundamental understanding of the optical and electronic properties in the solid-state (i.e. thin film active layer). These interactions are highly dependent on …

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Are We Becoming Superhuman Cyborgs? How Technomorphism Influences Our Perceptions Of The World Around Us, Heather Christina Lum Jan 2011

Are We Becoming Superhuman Cyborgs? How Technomorphism Influences Our Perceptions Of The World Around Us, Heather Christina Lum

Electronic Theses and Dissertations

Although traditionally researchers have focused on making robotics more user-friendly from a human perspective, a new theory has begun to take shape in which humans take on the perspective of a robotic entity. The following set of studies examined the concept of technomorphism defined as the attribution of technological characteristics to humans. This concept has been mentioned anecdotally and studied indirectly, but there is nothing currently available to tap in to the various forms that technomorphism may take. Therefore, one goal of this dissertation was to develop a scale to fill that purpose. The results of the Technomorphic Tendencies Scale …

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The Innate Anti-Hiv-1 Activity Of Human Seminal Plasma, Julie A. Martellini-Moore Jan 2011

The Innate Anti-Hiv-1 Activity Of Human Seminal Plasma, Julie A. Martellini-Moore

Electronic Theses and Dissertations

Human immunodeficiency virus (HIV) has become a global pandemic over the past few decades, with new infections and related deaths in the millions each year. There is no cure in sight for HIV-1 infection, and there has been little progress in developing an efficacious vaccine. Heterosexual transmission of HIV-1 remains the principal mode of transmission throughout the world and thus measures, such as topical vaginal microbicides, to prevent infection of the female reproductive tract are actively being explored. Recent trials of topical vaginal microbicides have shown that their interaction with the mucosal surfaces of the female reproductive tract as well …

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Florida School Indicator Report Data As Predictors Of High School Adequate Yearly Progress (Ayp), John D. Carr Jan 2011

Florida School Indicator Report Data As Predictors Of High School Adequate Yearly Progress (Ayp), John D. Carr

Electronic Theses and Dissertations

The focus of this research was to identify variables reported in the 2008-2009 Florida School Indicator Report (FSIR) that had a statistical impact, positive or negative, on the likelihood that a school would achieve Adequate Yearly Progress (AYP) in reading or mathematics using the logistic regression technique. This study analyzed four broad categories reported by the FSIR to include academic, school, student, and teacher characteristics. FSIR and AYP data was collected for 468 Florida high schools that were categorized by the Florida Department of Education as presenting a comprehensive curriculum to grades 9-12 or grades 10-12. It was determined in …

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Do Immigrant Students Consume Less Energy Than Native-Born American Students?, Lei Lei Jan 2011

Do Immigrant Students Consume Less Energy Than Native-Born American Students?, Lei Lei

Electronic Theses and Dissertations

This paper uses a sociological model to compare the residential energy consumption between immigrant students and native-born American students and to explain the difference by demographic characteristics, values, and specific attitudes. Further, it tries to explore whether the relationship between immigration status and residential energy consumption is mediated by value orientation towards frugality and specific attitudes towards energy conservation. The data of an online survey among native-born and foreign-born students at the University of Central Florida are used. The results suggest that immigrants consume less energy at home than native-born Americans, but the time stayed in the US doesn’t have …

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Variability Of Carbon Stock In Florida Flatwoods Ecosystems Undergoing Restoration And Management, Kathryn Elizabeth Becker Jan 2011

Variability Of Carbon Stock In Florida Flatwoods Ecosystems Undergoing Restoration And Management, Kathryn Elizabeth Becker

Electronic Theses and Dissertations

The global community is struggling with mitigating the effects of widespread habitat loss and degradation; the effects of which are being further magnified in the face of global climate change. Quality natural habitat is becoming increasingly limited and atmospheric carbon levels continue to rise. Therefore, land managers responsible for multiuse management are often faced with the dilemma of managing ecosystems for biodiversity, as well as optimizing ecosystem services such as carbon storage and sequestration. However, some management techniques used to meet these objectives may yield conflicting results, specifically, the management tool of prescribed fire. Fire is crucial in maintaining species …

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Stem Cell Biology And Strategies For Therapeutic Development In Degenerative Diseases And Cancer, Angel A. Alvarez Jan 2011

Stem Cell Biology And Strategies For Therapeutic Development In Degenerative Diseases And Cancer, Angel A. Alvarez

Electronic Theses and Dissertations

Stem cell biology is an exciting field that will lead to significant advancements in science and medicine. We hypothesize that inducing the expression of stem cell genes, using the embryonic stem cell gene nanog, will reprogram cells and dedifferentiate human mesenchymal stem cells into pluripotent stem cells capable of neural differentiation. The aims of initial studies are as follows: Aim 1: Demonstrate that forced expression of the embryonic stem cell gene nanog induces changes in human mesenchymal stem cells to an embryonic stem cell-like phenotype. Aim 2: Demonstrate that induced expression of nanog up-regulates the expression of multiple embryonic stem …

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Surface Entropy Reduction To Increase The Crystallizability Of The Fab-Rna Complex, Priyadarshini Palaniandy Ravindran Jan 2011

Surface Entropy Reduction To Increase The Crystallizability Of The Fab-Rna Complex, Priyadarshini Palaniandy Ravindran

Electronic Theses and Dissertations

Crystallizing RNA has been an imperative facet and a challenging task in the world of RNA research. Assistive methods such as Chaperone Assisted RNA Crystallography (CARC), employing monoclonal antibody fragments (Fabs) as crystallization chaperones have enabled us to obtain RNA crystal structures by increasing the crystal contacts and providing initial phasing information. Using this technology the crystal structure of [delta]C209 P4-P6 RNA (an independent folding domain of the self-splicing Tetrahymena group I intron) complexed to Fab2 (high affinity binding Fab) has been resolved to 1.95 Å (1). Although the complexed class I ligase ribozyme has also been crystallized using CARC …

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Applications Of Airborne And Portable Lidar In The Structural Determination, Management, And Conservation Of Southeastern U.S. Pine Forests, Claudia De Mendonca Costa Synek Listopad Jan 2011

Applications Of Airborne And Portable Lidar In The Structural Determination, Management, And Conservation Of Southeastern U.S. Pine Forests, Claudia De Mendonca Costa Synek Listopad

Electronic Theses and Dissertations

Active remote sensing techniques, such as Light Detection and Ranging (LiDAR), have transformed the field of forestry and natural resource management in the last decade. Intensive assessments of forest resources and detailed structural assessments can now be accomplished faster and at multiple landscape scales. The ecological applications of having this valuable information at-hand are still only being developed. This work explores the use of two active remote sensing techniques, airborne and portable LiDAR for forestry applications in a rapidly changing landscape, Southeastern Coastal Pine woodlands. Understanding the strengths and weaknesses of airborne and portable LiDAR, the tools used to extract …

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Nanoceria Inhibit The Development And Promote The Regression Of Pathologic Retinal Neovascularization In The Vldlr Knockout Mouse, Xiaohong Zhou, Lily L. Wong, Ajay S. Karakoti, Sudipta Seal, James F. Mcginnis Jan 2011

Nanoceria Inhibit The Development And Promote The Regression Of Pathologic Retinal Neovascularization In The Vldlr Knockout Mouse, Xiaohong Zhou, Lily L. Wong, Ajay S. Karakoti, Sudipta Seal, James F. Mcginnis

Faculty Bibliography 2010s

Many neurodegenerative diseases are known to occur and progress because of oxidative stress, the presence of reactive oxygen species (ROS) in excess of the cellular defensive capabilities. Age related macular degeneration (AMD), diabetic retinopathy (DR) and inherited retinal degeneration share oxidative stress as a common node upstream of the blinding effects of these diseases. Knockout of the Vldlr gene results in a mouse that develops intraretinal and subretinal neovascular lesions within the first month of age and is an excellent model for a form of AMD called retinal angiomatous proliferation (RAP). Cerium oxide nanoparticles (nanoceria) catalytically scavenge ROS by mimicking …

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Mutagenesis Of Tryptophan199 Suggests That Hopping Is Required For Maug-Dependent Tryptophan Tryptophylquinone Biosynthesis, Nafez Abu Tarboush, Lyndal M. R. Jensen, Erik T. Yukl, Jiafeng Geng, Aimin Liu, Carrie M. Wilmot, Victor L. Davidson Jan 2011

Mutagenesis Of Tryptophan199 Suggests That Hopping Is Required For Maug-Dependent Tryptophan Tryptophylquinone Biosynthesis, Nafez Abu Tarboush, Lyndal M. R. Jensen, Erik T. Yukl, Jiafeng Geng, Aimin Liu, Carrie M. Wilmot, Victor L. Davidson

Faculty Bibliography 2010s

The diheme enzyme MauG catalyzes the posttranslational modification of the precursor protein of methylamine dehydrogenase (preMADH) to complete biosynthesis of its protein-derived tryptophan tryptophylquinone (TTQ) cofactor. Catalysis proceeds through a high valent bis-Fe(IV) redox state and requires long-range electron transfer (ET), as the distance between the modified residues of preMADH and the nearest heme iron of MauG is 19.4 angstrom. Trp199 of MauG resides at the MauG-preMADH interface, positioned midway between the residues that are modified and the nearest heme. W199F and W199K mutations did not affect the spectroscopic and redox properties of MauG, or its ability to stabilize the …

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