Digital Commons Network^™

Self-Assembly Of Anti-Inflammatory Peptide Amphiphiles For Mucosal Health, Maria José Gómara, Ignacio Pérez-Pomeda, Ramon Pons, Paul Ziprin, Carolina Herrera, Isabel Haro

CONRAD Publications

Broad spectrum anti-inflammatory peptide amphiphiles (AIF-PAs) have been developed as an innovative strategy for the treatment of chronic mucosal inflammation and the prevention of HIV transmission. Novel lipopeptides based on two linear sequences of anti-inflammatory peptides were obtained by solid-phase peptide chemistry. In a pilot study, ex vivo exposure of colorectal tissue explants from Crohn's disease patients to AIF-PAs induced a downregulation of the proinflammatory profile. Furthermore, the HIV inhibitory potency of AIF-PAs was evaluated ex vivo in colorectal tissue explants, obtaining sub-micromolar IC₅₀ values. Characterization of AIF-PAs self-aggregation in aqueous solution revealed that the net charge distribution within the …

Artificial Intelligence And Machine Learning In Smart Vaginal Formulation Development, Deborah A. Ogundemuren, Vivek Agrahari, Andrew P. Wong, Carolina Herrera, Margaret O. Ilomuanya, Gustavo F. Doncel

CONRAD Publications

Vaginal drug delivery in women's health remains underutilized and insufficiently studied, largely due to the complexity and dynamic nature of the vaginal microenvironment. Variations in vaginal pH, hormonal levels, and microbiota composition introduce significant biological variability, complicating formulation design and contributing to inconsistent therapeutic outcomes and poor patient adherence. Conventional vaginal formulations often fail to account for these individual differences, highlighting the need for more adaptive and predictive approaches. Emerging advances in artificial intelligence (AI) and machine learning (ML) offer promising strategies to address these challenges by enabling multi-parameter, data-driven formulation development that explicitly considers biological variability. Despite their transformative …

Eeg Signatures Of Motor Development In Early Childhood: A Systematic Review, Sonia Khurana, Ashwini Kulkarni, Thomas C. Bulea, Hunter J. Bennett

Rehabilitation Sciences Faculty Publications

Background

Early identification of motor developmental disorders is limited due to lack of objective neural markers that characterize typical neurodevelopmental patterns. This systematic review interprets and synthesizes existing evidence to propose a framework of EEG signatures associated with motor development in children aged 0-5 years, which may help inform future benchmarks for early assessment and intervention.

Methods

Following PRISMA guidelines, we searched published and gray literature across five databases between 2000 and 2025 (registered protocol). Included studies examined EEG during task-based, resting-state, or sleep studies linked to motor milestones, task performance, or standardized motor assessments. Study quality was assessed using …

Characterization Of Phytoplankton-Excreted Metabolites Mediating Carbon Flux Through The Surface Ocean, Yuting Zhu, Hanna S. Anderson, Eli Salcedo, Samuel E. Miller, Krista Longnecker, Melissa C. Kido Soule, Sheean T. Haley, Gretchen J. Swarr, Rogier Braakman, Sonya T. Dyhrman, Elizabeth B. Kujawinski

Chemistry & Biochemistry Faculty Publications

The marine labile dissolved organic carbon (DOC) pool is a dynamic reservoir of thousands of molecules that cycles approximately one-quarter of Earth’s primary production within days to weeks. After excretion by phytoplankton and other microbes, metabolites are rapidly consumed, resulting in low standing concentrations (picomolar to low nanomolar). Despite the decades-long search for labile DOC sources and molecular identities, marine phytoplankton exometabolomes are not well characterized, largely due to difficulties in measuring small polar molecules in saline water. Here, we profiled the exometabolomes of six axenic phytoplankton species representing key functional groups including a diatom (Thalassiosira pseudonana CCMP1335), a …

Expanded Scorpionate And Siderophore-Inspired Ligands: From Foundational Designs To Modern Applications, Austin Winfield Medley, Trandon Allen Bender

Chemistry & Biochemistry Faculty Publications

Scorpionate ligands have been advanced significantly through systematic modifications of their apical atoms and heterocyclic arms, expanding their structural diversity and chemical reactivity. Recent biologically inspired variants now enable accurate modeling of complex bioinorganic motifs, such as the Fe₄S₄ clusters of nitrogenase, and support enzyme‐like reactivity under mild aqueous conditions. These developments have broadened the impact of scorpionate chemistry across bioinorganic modeling, homogeneous catalysis, and biorthogonal transformations. In particular, expanded tripodal scaffolds provide modular, tunable platforms for mimicking enzyme active sites and probing biological nitrogen fixation pathways. Beyond fundamental insight, these ligands present practical opportunities for sustainable catalysis by enabling …

The Coral Microbiome Under Climate Change: Shifting Symbiotic Interactions, Katherine E. Parker, Kate M. Quigley

Biological Sciences Faculty Publications

Host–microbe symbioses are central to organismal health, yet these complex partnerships are often strongly shaped by the environment. Climate change is increasingly altering environmental conditions, disrupting the balance of host–microbe interactions and pushing them along a continuum from mutualism (both partners benefit) toward parasitism (one partner gains at the other’s expense). Reef-building corals provide a clear example of this vulnerability, as the coral holobiont, an ecological unit comprising diverse photosynthetic algal symbionts (Symbiodiniaceae) and other microbial partners, depends largely on these mutualistic interactions for nutrition, immunity, and stress tolerance. Increasingly, evidence suggests that under heat stress, the algal symbionts retain …

[Review Of The Book A Conspectus Of The North American Isoetaceae, By D. F. Brunton, J. T. Kartesz, M. Nishino, And P. C. Sokoloff]., Lytton John Musselman

Biological Sciences Faculty Publications

Isoetes (Isoetaceae; Lycopodiopsida; quillworts) constitutes a highly successful, cosmopolitan genus with over 200 species. Isoetes is derived from isos Greek for equal and eter for year, referring to the typically long persisting leaves of the sole genus in this ancient plant family. The leaves resemble a ‘quill-of-feather,’ hence the common name ‘Quillworts,’ wort, from old Germanic wurti, meaning plant. In large measure due to its simple form, inconspicuous appearance and negligible economic value, it represents one of the least studied and least collected of all North American genera. Isoetes constitutes a taxonomically enigmatic group with numerous polyploid species that arose …

Mitochondrial Genome Of The Indo-Pacific Mesophotic Coral Leptoseris Columna (Scleractinia: Agariciidae) Assembled Using Pacbio Long-Read Sequencing, Nomita Rani Adhikary, Daniel J. Barshis, J. Antonio Baeza

Biological Sciences Faculty Publications

Leptoseris columna, a mesophotic coral species belonging to the family Agariciidae, is distributed throughout the Indo-Pacific region. This species is considered as of "Least concern" by the IUCN, yet, faces multiple local and global stressors. To support conservation plans, this study sequenced and characterized the complete mitochondrial genome of L. columna. The complete mitochondrial genome of Leptoseris columna was assembled using PacBio long-reads with a coverage of 459× per bp. The AT-rich mitochondrial genome of Leptoseris columna is 18,546 bp long and comprises 13 protein-coding genes (PCGs), 2 transfer RNA genes (trnM and trnW), and 2 ribosomal RNA …

Larval Genomics As A Viable, Fisheries-Independent Tool For Investigating Population Structure In Tropical Pacific Tunas, Jacob E. Jaskiel, Hannah E. Aichelman, Giulia Anderson, Louw Claassens, James E. Fifer, Christina M. Hernandez, Alexa K. Huzar, Joel K. Llopiz, Jan W. Witting, Sean P. Mullen, Randi D. Rotjan

Biological Sciences Faculty Publications

Understanding how dispersal, life history, and environmental variability shape genetic connectivity in the open ocean remains a central challenge in evolutionary biology. Highly migratory marine predators like tunas have traditionally been considered genetically homogeneous across ocean basins, yet emerging genomic evidence suggests that cryptic population structure can persist even in species with high gene flow and large effective population sizes. We used 2bRAD sequencing of 348 larval and subadult skipjack (Katsuwonus pelamis), yellowfin (Thunnus albacares), and bigeye tuna (T. obesus) collected from the central Pacific across 7 years of sampling to examine species boundaries, …

A Re-Evaluation Of Atlantic Bluefin Tuna (Thunnus Thynnus) Spawning Distribution In The Western Atlantic Ocean, David E. Richardson, Katrin E. Marancik, Malgorzata Adamus, Elizabeth A. Broughton, Robert K. Cowen, Trika Gerard, Christina M. Hernández, John J. Hoey, Joel K. Llopiz, Molly E. Lutcavage, Estrella Malca, Debra L. Palka, Lourdes Vásquez-Yeomans, Harvey J. Walsh, C. Michelle Willis, Glenn A. Zapfe

Biological Sciences Faculty Publications

There is currently a lack of consensus on the spatial, seasonal and decadal-scale patterns of Atlantic bluefin tuna (Thunnus thynnus) spawning in the western Atlantic Ocean. We compiled ichthyoplankton and reproductive data to characterize bluefin spawning patterns and the uncertainty in these patterns. Ichthyoplankton data indicates that bluefin spawn in the Gulf of America/Gulf of Mexico, northwest Caribbean Sea, north of the Bahamas, along the inshore edge of the Florida Current off the Carolinas and in the western Slope Sea. Reproductive studies identified these same spawning areas, as well as the Windward Passage and waters east of the …

The (Non) Numeric Truths Behind College And Career Aspirations: A Quantcrit Analysis Of The Precarious Pathways For Secondary Students Of Color, Norma A. Marrun, Danielle Mireles, Jori S. Beck, Christine Clark

Teaching & Learning Faculty Publications

This article explored the college and career choices of 963 students across six urban secondary schools in a large public school district in the Southwestern United States. A Quantitative Critical Race Theory, or QuantCrit, analysis was applied to expose the false narrative of number neutrality and the systemic racism that belies it. Findings demonstrate how the myth of meritocracy through education (as ‘the great equalizer’) is perpetuated when educators hold onto racist and ableist beliefs about who can pursue college, and ignore the structural disadvantages underlying the college and career aspirations of students of Color juxtaposed with the reality of …

Sulfhydryl-Functionalized Diarylethenes: Synthesis, Photoswitching, And Fluorescent Properties, Pramod Aryal, Jonathan Bietsch, Gowri Sankar Grandhi, Josh Choi, Guijun Wang

Chemistry & Biochemistry Faculty Publications

Sulfhydryl group (SH) plays important roles in reactions with various functional groups, especially in biologically active systems. Photoswitchable diarylethene (DAE) derivatives have demonstrated applications in many research fields. Among the many classes of diarylethene derivatives, thiol derivatives have not been extensively explored. In this study, we systematically synthesized and characterized a series of bis-thiol functionalized dithienylethene derivatives. The thiol groups in this series are attached directly to the thiophene, or through a phenyl or methylene linker. Each series incorporated both dithienyl cyclopentene and hexafluorocyclopentene bridges and total six thiol substituted diarylethenes were synthesized. Among the six sulfhydryl DAE derivatives, four …

Nonpyrogenic "Black" Nitrogen Likely Plays A Major Yet Underrecognized Role In The Global Nitrogen Cycle, João Vitor Dos Santos, Aleksandar I. Goranov, Kyle M. Lambert, Theodoro Da Rosa Salles, Susan J. Carter, Ann Pearson, Patrick G. Hatcher

Chemistry & Biochemistry Faculty Publications

Condensed aromatic nitrogen (ConAN) is commonly found in soil and aquatic environments. ConAN is broadly viewed by the biogeochemistry community as a combustion-derived product leading to its frequent designation as pyrogenic “black” nitrogen. Here, we provide evidence that ConAN can also form through nonpyrogenic pathways. In an experiment simulating biomass oxidation, pine wood boards assembled with iron nails were exposed to 12 years of natural environmental conditions. Nitrogen concentrations increased from 0.2 to 1.2 wt % with increasing proximity to the nail. Ultrahigh resolution mass spectrometry showed enrichment of nitrogen-containing compounds within the lignin and condensed aromatic domains. X-ray spectroscopic …

Land Use Influences Dissolved Organic Matter Composition In The U.S. Coastal Critical Zone Network, Aleksandar I. Goranov, Elizabeth V. Whitney, Brian R. Moyer, Katherine L. Tully, Patrick G. Hatcher, Yu-Ping Chhin

Chemistry & Biochemistry Faculty Publications

Coastal watersheds are highly productive biogeochemical systems supporting robust coastal fisheries and contributing significantly to the marine gross primary production flux. These ecosystems are comprised of civil infrastructure, farms, forests, and marshes, and their diversity is reflected in the quantity and quality of dissolved organic matter (DOM). Here, we assess the role of farming in influencing DOM from surface waters of six coastal tidal creeks adjacent to forest and farm sites in the US Critical Zone Network. Molecular fingerprinting using electrospray ionization - Fourier transform - ion cyclotron resonance - mass spectrometry revealed that farm-influenced DOM was enriched in nitrogen-, …

Multidentate Surfactant-Dependent Synthesis Of Giant Iridium Superstructures, Ramjee Balasubramanian, Maeren E. Hill

Chemistry & Biochemistry Faculty Publications

Giant superstructures of iridium, comprised of smaller spherical and slightly larger anisotropic nanoparticles, were synthesized by reducing iridium chloride in the presence of resorcinarene, a class of tetrameric macrocyclic polyphenols, with sodium borohydride in ethanol in 30 min under mild conditions. These superstructures were characterized by a range of techniques including TEM, HRTEM, EDS and other spectroscopic methods. The impact of the macrocyclic surfactant, its features and reaction conditions in dictating the formation of giant iridium superstructures was evaluated. The packing density of nanoparticles in these giant iridium superstructures could be altered qualitatively by varying the duration of the reaction, …

The Impacts Of Outside Friendships On Marital Satisfaction In The Orthodox Jewish Population, Rebecca Elberger

Selected Full Text Dissertations, 2011-

There is robust literature that supports the idea that maintaining a strong network of friends and social ties can help reduce the pressure on marriage and contribute to a more balanced and fulfilling life. Additionally, George et al. (2023) found that friendships significantly impact relational satisfaction, across individual, family, and mutual friend groups. A regression analysis in their study revealed that family support for the relationship and liking the partner were the greatest predictors of satisfaction. There are approximately 2 million Jewish people in the Greater New York area and there has been a steady increase in the Jewish population …

Mothers' Perspectives Of Behavioral Parent Training: A Qualitative Study, Ryan Schare M.S.

Selected Full Text Dissertations, 2011-

Externalizing disorders such as oppositional defiant disorder, conduct disorder, and attention deficit hyperactivity disorder are the most common difficulties children face, with only half of children with these diagnoses receiving mental health treatment (Ghandour et al., 2019). Behavioral parent training (BPT) has been shown to be effective for treating externalizing disorders, yet parents exhibit low attendance and high dropout rates (Chacko et al., 2016). Researchers have examined parental acceptability of specific BPT skills (e.g., Calzada et al., 2013); however, no studies have focused on parents’ perceptions of BPT as an overall treatment package prior to participating in BPT. The present …

Systematics Of Disk-Winged Bats (Thyroptera), Courtney L. Klumpp

Capstone Showcase

This thesis investigates the evolutionary relationships among disk-winged bats in the genus Thyroptera, a small group of Neotropical bats known for the adhesive suction disks on their wings and feet that allow them to roost inside tightly rolled leaves. The distinctive morphology and behavior of these bats have not been extensively documented, and their phylogenetic relationships remain only partially resolved. The goal of this research is to better understand how these species are related to one another and to determine whether the five recognized species of Thyroptera form a single monophyletic group. To address this question, morphological and genetic …

Racial Disparities In Maternal Mortality: The Role Of Explicit And Implicit Bias In U.S. Healthcare, Lailah Allen

Capstone Showcase

Maternal mortality in the United States remains a critical public health crisis, with disproportionately high rates among Black and other minority women. Despite advances in obstetric medicine, racial disparities in pregnancy-related deaths persist due to structural inequities, implicit bias in healthcare delivery, unequal access to prenatal and postpartum care, and broader social determinants of health. Nationally, Black women are significantly more likely to experience severe maternal morbidity and mortality compared to White women, reflecting longstanding inequities embedded within the healthcare system. This paper examines the relationship between race, healthcare access, and maternal outcomes through a focused case study of and …

America’S Spectacle: The Business Of Female Beauty In Professional Cheerleading, Marlene Adelman

Capstone Showcase

The National Football League (NFL) is built on values that also represent the deep rooted patriarchal structures within the country it exists in. The NFL is more than a game; it’s a mirror of America’s powerful subjugation of its women. Using one of the most recognizable cheerleading teams, the Dallas Cowboys Cheerleaders, this thesis aims to illustrate how gender is constructed and commodified in professional sports media, which reinforces the male gaze, furthers racial and gender inequalities, and contributes to women’s mental health and body image issues. This paper uses several theories, including male gaze, gender, and intersectionality, along with …

Visual Aids And Numeracy In Healthcare: Leveraging The Drawing Effect, Zephyr J. Markley

Capstone Showcase

Healthcare decisions often require patients to interpret numerical risk information under stress, yet many struggle with low numeracy, which can distort comprehension and undermine informed consent. Well-designed visual aids can improve diagnostic inference, calibrate confidence, and support better choices, especially for patients with limited numeracy, but their impact depends on whether users can actually interpret the format accurately. Drawing may further enhance these tools by adding a tactile, generative layer that engages visual, semantic, and motoric processing while helping patients organize information into concrete models.

Passive visual aids appear useful but limited because they often position patients as observers rather …

Effect On C5 Myotome Distribution After Cervical Spinal Surgery: A Case Report On Early Neuromuscular Re-Education, Nicole Eder Asebias

Capstone Showcase

Background and Purpose: Postoperative C5 palsy is a known problem after cervical spinal surgery and is characterized by upper extremity weakness that can significantly limit the ability to perform daily tasks. Despite its clinical relevance, limited literature describes physical rehabilitation-focused interventions strategies for this condition. The purpose of this case report is to describe the presentation, physical therapy intervention, and outcomes of a patient with postoperative C5 palsy managed with neuromuscular re-education.

Case Description: The patient is an adult who developed left upper extremity weakness consistent with C5 palsy following cervical spinal surgery. Primary impairments included decreased shoulder abductor and …

Why Physical Environment Matters: The Cognitive Effects In Elementary Classrooms, Amanda Cavender

Integrated Studies

All physical elements, such as color, lights, acoustics, and furniture must work cohesively with the layout and space to create a welcoming, calm, and inclusive classroom.  This paper reviews the data surrounding these physical elements and their correlation with academic success.  Academic success in this case is defined as scores students achieve, the speed at which they can complete work, the accuracy of completed work, and attention spans.  The quality of school building plays a crucial role here; Temperature control, adequate space, and insulation are crucial to be able to properly control the environment.  Regarding lighting, studies have shown that …

Substance Abuse: Causes, Effects, And Treatment Approaches, Ambrea A. Watkins

Integrated Studies

Abstract

Substance abuse continues to be one of the most significant public health and social challenges facing the United States. Substance use disorders affect millions of individuals each year and have serious consequences for families, communities, and public systems such as healthcare and criminal justice. Addiction is widely recognized as a chronic brain disease that can alter behavior, decision making, and impulse control. Many individuals who struggle with substance abuse also experience related issues such as mental illness, homelessness, poverty, and involvement in the criminal justice system.

This research paper examines the causes, impacts, and treatment approaches related to substance …

"As A Woman I Have No Country": Patriarchy And Patriotism In Virginia Woolf's Interwar Fiction, Katherine S. Cole

Scripps Senior Theses

This paper examines the evolving ways in which the ideological framework of Virginia Woolf's political essay Three Guineas manifests in her fiction, as well as how it is shaped by both world wars. In analyses of Mrs. Dalloway, Orlando, The Years, and Between the Acts, I examine Woolf’s critiques of the masculine-patriotic-imperial value system that structures English society, its interdependence with the patriarchal tyranny of the domestic sphere, and how these critiques are complicated by a fraught relationship to Englishness that often balances sentimentality, personal attachment, and the fear of identity loss with the fiercely critical feminist-pacifist perspective articulated in …

The Split Child: Fragmented Temporalities And Selves In Post-Francoist Horror Cinema, Harper A. Denniston

Scripps Senior Theses

This thesis interrogates the prolific figure of the spectral child in post-dictatorial horror cinema in Spain. During the renaissance wave of the horror boom (a period between the late 1990s and early 2000s that experienced a surge in horror films), narratives of haunting often presented the ghost in child form, blending childhood and horror. This thesis examines the spectral child as depicted in the seminal horror films The Devil’s Backbone (2001) and The Orphanage (2007). First, I establish the historical context behind these films, exploring the traumatic history of children during the Spanish Civil War and Franco dictatorship, Spain’s cultural …

“Beejagalu Namma Jeevana” (Seeds Are Our Life): Women Farmers’ Relational Practices Of Care, Labor, And Life Within Regenerative Systems In South India, Sara F. Mehkri

Scripps Senior Theses

“Beejagalu Namma Jeevana” (Seeds are Our Life): Women Farmers’ Relational Practices of Care, Labor, and Life within Regenerative Systems in South India, examines the role of women farmers in regenerative agricultural systems in Kanakapura, Karnataka, through ethnographic fieldwork with GREEN Foundation (GF) and its farmer networks. It argues that regenerative agriculture in this context is produced through care-based multispecies assemblages that reconfigure relationships between labor, knowledge, and ecological life, generating resilient socio-agroecological systems and expanding forms of human capability.

Drawing on twenty semi-structured interviews with women farmers, participant observation, and historical analysis of agrarian change in South India, this thesis …

Redling And Soil Contamination In Los Angles County: Mapping The Influence Of Polutants And Regulatory Landscapes On Enviromental Justice Outcomes, Gillian G. Maynard

Scripps Senior Theses

This thesis examines soil contamination in Los Angeles as a pervasive yet underexamined environmental justice issue, rooted in the region’s history of industrialization, racialized land-use policy, and regulatory failure. It argues that soil operates as both a long-term repository and an active pathway of toxic exposure, embedding environmental risk directly within residential landscapes. Through an analysis of key contamination sources, including legacy lead pollution, urban oil extraction, wildfire-related toxins, and industrial sites such as the Santa Susana Field Laboratory and the Exide battery recycling facility, this study demonstrates how contaminants persist across generations, often long after their original sources have …

The Effect Of The Affordable Care Act Medicaid Expansion On The Risk Of Hospital Closure And Adolescent Hpv Immunization In Rural Counties, Juliette Des Rosiers

Scripps Senior Theses

From 2005 to 2025, over 200 rural hospitals shut their doors, often citing increased operational costs, staffing shortages, low patient volume, regulatory barriers, financial challenges exacerbated by the COVID-19 pandemic, and uncompensated care as common contributors to the closures. Rural patients are often referred by their primary care physician to a hospital for regular immunizations, since smaller clinics have less capacity to provide immunizations due to a shortage of pediatricians and limited vaccine stock. A crucial vaccine that is not required by schools and underutilized in rural areas is that against human papillomavirus (HPV), a virus that infects cutaneous and …

Development Of A Bidirectional Tmv-Based Plant Expression Vector For Dual Gene Co-Expression, Matisse Schutten-Burgess

Scripps Senior Theses

Monoclonal antibodies, or mAbs, have recently joined the growing array of biopharmaceuticals used to treat a variety of chronic, autoimmune, and infectious diseases. Antibody therapy is highly customizable, as mAbs can be genetically engineered to target specific disease markers. Traditional systems of producing monoclonal antibodies use mammalian cells, most prominently Chinese Hamster Ovary Cells. While these systems are widely used, they are time-intensive and costly. Because of this, plant-based antibody production systems have risen in prominence, as they provide a more cost-efficient and faster way to generate antibodies. One drawback that has surfaced is that the co-expression of antibody heavy …