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2011

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Encounters With The Outcast : The Ethical Relation In Wordsworth And Lacan, Heewon Kang Jan 2011

Encounters With The Outcast : The Ethical Relation In Wordsworth And Lacan, Heewon Kang

Legacy Theses & Dissertations (2009 - 2024)

This dissertation examines the ethical importance of the moments in William Wordsworth's poetry when language verges on silence or presents experience as finally unintelligible, and explores the ethical dimension of outcast figures intimately connected with the problem of this void in signification, on the basis of Jacques Lacan's insights concerning psychoanalytic ethics. The question that orients the examination of the ethical issues embodied in Wordsworth's poetry is how one should encounter or represent the outcast figure as a rupture in meaning. And the ethics of subjectivity which Lacan explores in terms of his theories of the gaze, feminine jouissance, and …

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A Functional Study Of Ampa And Kainate Receptors, Yan Han Jan 2011

A Functional Study Of Ampa And Kainate Receptors, Yan Han

Legacy Theses & Dissertations (2009 - 2024)

The ionotropic glutamate receptors are localized in the pre- and postsynaptic membrane of neurons and mediate the majority of fast excitatory synaptic transmission. These receptors are divided into three subtypes: α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), kainic acid, and N-methyl-D-aspartic acid (NMDA) receptors. My thesis work focused on AMPA and kainate receptor subtypes.

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The Causes Of Risky Sexual Behavior Over The Adolescent-Young Adult Life Course And Its Consequences For Partner Relationships In Adulthood, Nicole Marie Schmidt Jan 2011

The Causes Of Risky Sexual Behavior Over The Adolescent-Young Adult Life Course And Its Consequences For Partner Relationships In Adulthood, Nicole Marie Schmidt

Legacy Theses & Dissertations (2009 - 2024)

This dissertation uses data from the Rochester Youth Development Study (RYDS) to examine the causes and consequences of risky sexual behavior from adolescence through young adulthood using a developmental perspective. Developmental theories suggest that antisocial behavior, especially persistent antisocial behavior, during adolescence can amplify the effects of early family, school, and peer factors by setting in motion a chain of cumulative disadvantages that increase the likelihood that one will experience negative outcomes in adulthood. Drawing on developmental theories of antisocial behavior, the causes and consequences of risky sexual behavior are examined. First, wave-specific measures of risky sexual behavior spanning six …

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Single Cell Analysis For The Characterization Of Cell Populations Using A Live Cell Array, Maureen Ann Walling Jan 2011

Single Cell Analysis For The Characterization Of Cell Populations Using A Live Cell Array, Maureen Ann Walling

Legacy Theses & Dissertations (2009 - 2024)

In the past decade, the shift from whole cell population analyses towards single cell measurement methods and techniques is based on experimental results that reveal significant levels of non-genetic heterogeneity in clonal cell populations. This heterogeneity manifests in multiple aspects of cell activity and is, in part, a result of stochastic noise in processes leading to gene expression, namely transcription and translation. The growing understanding of this occurrence has led to the development of methods to monitor and analyze heterogeneity for a more thorough description of cell populations and overall activity.

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Cost-Effective Imprint Template Fabrication For Step And Flash Imprint Lithography, Adam Marc Munder Jan 2011

Cost-Effective Imprint Template Fabrication For Step And Flash Imprint Lithography, Adam Marc Munder

Legacy Theses & Dissertations (2009 - 2024)

The College of Nanoscale Science and Engineering (CNSE) is studying imprint template fabrication with the 100kV Vistec VB300 Gaussian E-Beam writer. The major goal is to develop and advance imprint template fabrication technology using low cost quartz wafers for proof-of-concept demonstrations.

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The Nasal Toxicity Of The Herbicide 2,6-Dichlorobenzonitrile : Mechanisms And Biomarkers, Fang Xie Jan 2011

The Nasal Toxicity Of The Herbicide 2,6-Dichlorobenzonitrile : Mechanisms And Biomarkers, Fang Xie

Legacy Theses & Dissertations (2009 - 2024)

The overall goal of this study is to investigate mechanisms of the potent nasal specific toxicity of the herbicide 2,6-dichlorobenzonitrile (DCBN) in rodents, and to determine whether DCBN could induce similar nasal toxicity in humans. The central hypotheses are 1) that the nasal specific toxicity of DCBN in rodents is mediated by its electrophilic intermediates that are formed through metabolic activation catalyzed by target tissue cytochrome P450 enzymes (P450) and can interfere with stem cell regeneration and differentiation in the olfactory epithelium (OE); and 2) that human nasal tissues are also capable of catalyzing bioactivation of DCBN. The specific aims …

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Gringotenango : The U.S. Retirement Migration To Antigua, Guatemala, Katherine Wilnelia Platt Jan 2011

Gringotenango : The U.S. Retirement Migration To Antigua, Guatemala, Katherine Wilnelia Platt

Legacy Theses & Dissertations (2009 - 2024)

This dissertation documents the migration of U.S. retirees to Antigua, Guatemala. Antigua is a charming Spanish colonial city in the middle of the Guatemalan highlands with beautiful volcano views, cobblestone roads, the presence of Mayan and Ladino cultures, and an eternal spring climate. The physical and cultural beauty of Antigua allows U.S. citizens to enjoy a permanent vacation-like retirement experience. Antigua, however, is located in a country whose recent history is characterized by 36 years of civil war, and current events are stressed by new violence criminal activities. Despite the beauty of Antigua, this colonial city is an odd retirement …

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Comparing Collocated And Non-Collocated Licensed Substance Abuse Outpatient Clinics In New York State : A Program Level Analysis, Bradley R. White Jan 2011

Comparing Collocated And Non-Collocated Licensed Substance Abuse Outpatient Clinics In New York State : A Program Level Analysis, Bradley R. White

Legacy Theses & Dissertations (2009 - 2024)

Objective. The study addresses two research aims: (1) to examine the extent to which caseload and program characteristics differ across substance abuse outpatient programs with respect to collocation with licensed mental health outpatient clinic programs and (2) to investigate the relationship between collocation and program level service outcomes.

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Delta Woman With Faulkner And Hitchcock, Mi-Jeong Kim Jan 2011

Delta Woman With Faulkner And Hitchcock, Mi-Jeong Kim

Legacy Theses & Dissertations (2009 - 2024)

Lacan, as a post-structuralist, combined Saussure's linguistics with Freud's psychology and linked Derrida's notion of "the other" to his notion of "objet petit a" as the impossible object of the subject's phallic desire, in order to re-think the modern consciousness of "the self." In the Lacanian account, "the other" does not exist as the 'absolute' transcendental without involvement, but ex-sists as the traumatic and 'extimate' exteriority with-in "the self." The ex-centric other is epitomized by the iconic (inverted) triangular center of Lacan's Borromean Knot. As the immanent exteriority of both the subject and the Symbolic, the feminine (w)hole, resembling vaginal …

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The Differential Effects Of Genetic And Dietary Alterations In Folate Status On Prefrontal Cortical Functions, Jessica Amanda Ash Jan 2011

The Differential Effects Of Genetic And Dietary Alterations In Folate Status On Prefrontal Cortical Functions, Jessica Amanda Ash

Legacy Theses & Dissertations (2009 - 2024)

Folate status plays an essential role in embryogenesis and brain development; however, its importance in supporting cognitive functioning throughout adulthood is less clear. The present study was interested in examining the effects of genetic and dietary alterations in folate status on prefrontal cortical functions in mice, modeling a common polymorphism in the MTHFD1 gene in folate metabolism. A factorial design was used crossing two genotypes (mice with a gene trap insertion in the Mthfd1 gene exhibiting 50% decreased Mthfd1 expression: Mthfd1gt/+ mice or wildtype mice) with two levels of dietary folate (folate sufficient or folate deficient). The mice were tested …

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Puerto Rican Intermarriages : The Intersectionality Of Race, Gender, Class And Space, Gabriel Aquino Jan 2011

Puerto Rican Intermarriages : The Intersectionality Of Race, Gender, Class And Space, Gabriel Aquino

Legacy Theses & Dissertations (2009 - 2024)

Puerto Ricans have an intermarriage rate of 38.5 percent, the highest among Mexican, Cubans, Dominicans, European Americans, and African Americans in the United States. What govern the process of Puerto Rican intermarriage? Who do Puerto Rican intermarry with? And, do these intermarriages affect Puerto Rican ethnic identity? Traditional theories of intermarriage use a one dimensional explanation for intermarriages and for many posit an eventual ethnic identity transition. I propose the use of an intersectionality paradigm that incorporates a multidimensional approach, specifically race, gender, class, and space to explain Puerto Rican intermarriage and to test Puerto Rican ethnic identity transformation through …

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Blanding's Turtle (Emydoidea Blandingii) In Saratoga County, New York : Survey Methods, Spatial Ecology And Conservation, Andrea Chaloux Jan 2011

Blanding's Turtle (Emydoidea Blandingii) In Saratoga County, New York : Survey Methods, Spatial Ecology And Conservation, Andrea Chaloux

Legacy Theses & Dissertations (2009 - 2024)

In 2003, a small, isolated population of the New York State Threatened Blanding's Turtle (Emydoidea blandingii) was documented in Saratoga County, New York, between the main range and eastern range of the species, approximately 120 km from the nearest known population. The location of the population and its occupancy of a protected preserve in an area experiencing heavy development pressure prompted the need for an immediate conservation-focused study. Building upon work of New York State Department of Environmental Conservation staff from 2003-2006, a trapping (2007-2008) and radio-telemetry (2007-2009) study was conducted with the following objectives: 1) inform survey protocol recommendations …

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Pcbs And Measures Of Attention And Impulsivity On A Continuous Performance Task Of Young Mohawk Adults, Bita Behforooz Jan 2011

Pcbs And Measures Of Attention And Impulsivity On A Continuous Performance Task Of Young Mohawk Adults, Bita Behforooz

Legacy Theses & Dissertations (2009 - 2024)

Past animal and human studies have shown that exposure to PCBs can result in a wide range of negative toxic effects. However, only a few studies have investigated the relationship between PCB exposure and attention and impulsivity. The present study examined the relationship between current body burden levels of PCBs and attention and impulsivity in young adults ages 17 to 21 from the Mohawk Nation of Akwesasne. The community is concerned because PCBs from industrial effluent have contaminated the local ecology and entered the Mohawk's food chain. Attention and impulsivity were measured by errors of omission and errors of commission …

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New Photoluminescent Copper(I) Complexes : Impact Of Bridging Carboxylates On Solid-State Structures And Photophysical Properties, Oleksandr Hietsoi Jan 2011

New Photoluminescent Copper(I) Complexes : Impact Of Bridging Carboxylates On Solid-State Structures And Photophysical Properties, Oleksandr Hietsoi

Legacy Theses & Dissertations (2009 - 2024)

Polynuclear copper(I) carboxylates exhibiting rich luminescent properties and a remarkable structural diversity have been the main focus of this investigation. In spite of the well-developed methods of copper(I) carboxylates synthesis, only a handful of complexes have been crystallographically characterized prior to our work. Notably, they all demonstrate different structural arrangements in the solid state. This dissertation describes the work that has been carried out towards the synthesis of new copper(I) carboxylates, the study of their molecular and solid-state structures, and their solid-state photoluminescent (PL) properties. In this work, we have prepared a series of new copper(I) carboxylates of the general …

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Adolescent Dating Experience And Delinquency, Ryang Hui Kim Jan 2011

Adolescent Dating Experience And Delinquency, Ryang Hui Kim

Legacy Theses & Dissertations (2009 - 2024)

The research literature on adolescent development has discussed adolescent dating in relation to behavioral changes. However, very little discussion has been devoted to theoretical explanations of the intricacies involved in the relationship between the adolescent dating experience and the development of delinquent behavior. Consequently, there seems to be a lack of understanding as to how dating activities in adolescence influence delinquency, aside from a general consensus that adolescent dating tends to be related to deviant behavior.

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Adult Memory And Appraisal Of Maltreatment In Childhood : Implications For Problem Substance Use, Laura J. Elwyn Jan 2011

Adult Memory And Appraisal Of Maltreatment In Childhood : Implications For Problem Substance Use, Laura J. Elwyn

Legacy Theses & Dissertations (2009 - 2024)

Objective: Alcohol and drug abuse are major public health concerns. Child maltreatment has been identified as a risk factor that increases the likelihood of substance use problems in adulthood. However, most studies have used retrospective reports of maltreatment and the few studies that have used prospective measures of maltreatment have found a weaker association with adult substance use problems. This study examines whether adult memory and appraisal of maltreatment is the primary pathway through which substantiated child maltreatment effects adult substance use problems.

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The Impact Of Exposure To Domestic Violence On Developmental Trajectories Of Depressive Symptoms And Antisocial Behavior Across The Transition To Adulthood, Aely Park Jan 2011

The Impact Of Exposure To Domestic Violence On Developmental Trajectories Of Depressive Symptoms And Antisocial Behavior Across The Transition To Adulthood, Aely Park

Legacy Theses & Dissertations (2009 - 2024)

Principal Aims:

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Evaluation Of A Biopesticide Against Invasive Species For Native Species Restoration, Denise Ann Mayer Jan 2011

Evaluation Of A Biopesticide Against Invasive Species For Native Species Restoration, Denise Ann Mayer

Legacy Theses & Dissertations (2009 - 2024)

Since their introduction in the 1980s, dreissenid mussels (Dreissena polymorpha and D. rostriformis bugensis) rapidly spread throughout North America and have had severe impacts on the ecology of freshwater ecosystems. A project was initiated in the early 1990s at the New York State Museum's Field Research Laboratory to discover and develop natural products to control industrial biofouling by dreissenid mussels. A strain of Pseudomonas fluorescens (Pf-CL145A), isolated from the sediment of a North American river, was found to be effective at killing dreissenids. The strain was patented for this use.

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Structural Interactions And Dynamics Of Disease Related Proteins By Using Nmr Spectroscopy, Shadakshara Swamy Puttamadappa Jan 2011

Structural Interactions And Dynamics Of Disease Related Proteins By Using Nmr Spectroscopy, Shadakshara Swamy Puttamadappa

Legacy Theses & Dissertations (2009 - 2024)

Nuclear Magnetic Resonance (NMR) is a powerful spectroscopic technique to study the structure, molecular interactions, and dynamics of proteins. Modern NMR instrumentation, advancements in experimental techniques and revolutionary developments in recombinant DNA technology have made NMR a versatile and very convenient tool for biomolecule characterization.

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A Comparative Evaluation Of Acceptance And Cognitive Restructuring Techniques For Coping With Acute Panicogenic Distress : An Experimental Evaluation In An Anxious Non-Clinical Sample, Erica Moses Jan 2011

A Comparative Evaluation Of Acceptance And Cognitive Restructuring Techniques For Coping With Acute Panicogenic Distress : An Experimental Evaluation In An Anxious Non-Clinical Sample, Erica Moses

Legacy Theses & Dissertations (2009 - 2024)

Cognitive-behavioral therapy (CBT), an approach that emphasizes increasing perceptions of control and cognitive change through cognitive restructuring, has proven to be an efficacious treatment for panic disorder. However, significant proportions of patients fail to achieve clinically significant improvement. Acceptance, an alternative contextually-based approach to content- and change-based cognitive strategies, has gained popularity within the field. Research on the utility of acceptance-based strategies for anxiety is promising, particularly in comparison to control-based emotion regulation strategies, such as suppression and distraction. Yet, to date, no studies have rigorously compared acceptance-based strategies to analogs of cognitive-behavioral techniques. The present study is the first …

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In-Cell And In Vitro Studies Of Disease Related Protein-Protein Interactions Using Nmr-Spectroscopy, Andres Yudiel Maldonado Jan 2011

In-Cell And In Vitro Studies Of Disease Related Protein-Protein Interactions Using Nmr-Spectroscopy, Andres Yudiel Maldonado

Legacy Theses & Dissertations (2009 - 2024)

The receptor for advanced glycation end products (RAGE) is a multiligand cell surface macromolecule that plays a central role in the etiology of diabetes, inflammation, and neurodegeneration. The cytoplasmic domain of RAGE, ctRAGE, is critical for RAGE-dependent signal transduction. As the most membrane proximal event, mDia1 binds to ctRAGE and is essential for RAGE ligand-stimulated phosphorylation of AKT and cell proliferation/migration. We show that ctRAGE contains an unusual alpha-turn that mediates the mDia1-ctRAGE interaction and is required for RAGE dependent signaling. The results establish a novel mechanism through which an extracellular signal initiated by RAGE ligands regulates RAGE signaling in …

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Darwin's Other Idea : Sexual Selection, Gender And Violence, Robert Samuel Moschgat Jan 2011

Darwin's Other Idea : Sexual Selection, Gender And Violence, Robert Samuel Moschgat

Legacy Theses & Dissertations (2009 - 2024)

This dissertation provides an empirical exploration of Darwin's theory of sexual selection, which views the male propensity to engage in short term mating strategies--sexual promiscuity and violence--as the result of sexual selection. Within an environmental context, biological father and mother household presence are expected to inhibit the initiation of short-term mating strategies and increase parental investment--paternal and maternal attachments, supervision, and protection. Whereas, structural disadvantage--living in poverty and in dangerous neighborhoods--is predicted to increase the initiation of a short-term mating strategies and compromise the parents' ability to protect their children and by weakening paternal and maternal attachments, thereby increasing the …

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Creating Rna Aptamers To Modulate Function Of Human Estrogen Receptor Alpha, Daiying Xu Jan 2011

Creating Rna Aptamers To Modulate Function Of Human Estrogen Receptor Alpha, Daiying Xu

Legacy Theses & Dissertations (2009 - 2024)

ABSTRACT

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Applying X-Ray Microscopy And Finite Element Modeling (Fem) To Identify The Mechanism Of Stress-Assisted Void Growth In Through Silicon Via (Tsv), Lay Wai Kong Jan 2011

Applying X-Ray Microscopy And Finite Element Modeling (Fem) To Identify The Mechanism Of Stress-Assisted Void Growth In Through Silicon Via (Tsv), Lay Wai Kong

Legacy Theses & Dissertations (2009 - 2024)

Fabricating through-silicon vias (TSVs) is challenging, especially for conformally filled TSVs, often hampered by the seam line and void inside the TSVs. Stress-assisted void growth in TSVs has been studied by finite element stress modeling and X-ray computed tomography (XCT). Because X-ray imaging does not require TSVs to be physically cross-sectioned, the same TSV can be imaged before and after annealing. Using 8 keV laboratory-based XCT, voids formed during copper electroplating are observed in as-deposited samples and void growth is observed at the void location after annealing. We hypothesize that the mechanism generating voids is hydrostatic stress-assisted void growth. Stresses …

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A Biophysical Study Of Small Molecule-Nucleic Acid Interactions, Rajiv Thapa Jan 2011

A Biophysical Study Of Small Molecule-Nucleic Acid Interactions, Rajiv Thapa

Legacy Theses & Dissertations (2009 - 2024)

Nucleic acids are the biomolecules that encodes all the genetic information necessary for cellular metabolism. Binding of small molecules to DNA or RNA can alter their structures; perturb their functions as well as interactions with proteins and other ligands. This thesis focuses on the biophysical study of the interactions of three planar compounds with TAR 32 DNA (32 ntds DNA in HIV-1 LTR, Figure. The purpose for this study is to understand the binding modes of some of the potential drug target compounds, which will be useful for future rational drug design strategies.

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The Effect Of Cognitive Behavioral Therapy (Cbt) On Driving While Intoxicated Offenders, Thomas P. Quinn Jan 2011

The Effect Of Cognitive Behavioral Therapy (Cbt) On Driving While Intoxicated Offenders, Thomas P. Quinn

Legacy Theses & Dissertations (2009 - 2024)

Social work research on evidence based practices in the area of driving while intoxicated could add to the development of reasoned policies essential to resource allocation. The purpose of this longitudinal study was to evaluate differences over time in DWI recidivism among defendants with multiple DWI offenses after receiving a Cognitive Behavioral Therapy (CBT) curriculum. A convenience sample of defendants on Probation supervision with histories of repeated DWI offenses (N = 286; m = 240, f = 46) were referred to the CBT program which was delivered by a clinical psychologist. Major findings included a significant difference at the .05 …

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Cardiovascular Reactivity And Recovery To Stressful Tasks Following A Mindfulness-Analog In College Students With A Family History Of Hypertension, Christoffer Grant Jan 2011

Cardiovascular Reactivity And Recovery To Stressful Tasks Following A Mindfulness-Analog In College Students With A Family History Of Hypertension, Christoffer Grant

Legacy Theses & Dissertations (2009 - 2024)

Ninety-seven undergraduate students with a family history of hypertension participated in a study that evaluated the effects of a brief mindfulness-induction on cardiovascular reactivity and recovery to two stressors. Participants were randomized to either a mindfulness-induction or control condition and were then exposed to the cold pressor task (CPT) followed by the mirror-tracing task (MT). Blood pressure and heart rate were measured at baseline, post-induction, as well as during and immediately following each stressor. There were no group differences in reactivity to either stressor. Participants in the mindfulness-analog condition experienced significantly greater latency to systolic blood pressure recovery following the …

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Distinct Functions Of The Fshr Ck2 Consensus Sequence And Ck2 Kinase Activity In Fsh Action, Kerri S. Kluetzman Jan 2011

Distinct Functions Of The Fshr Ck2 Consensus Sequence And Ck2 Kinase Activity In Fsh Action, Kerri S. Kluetzman

Legacy Theses & Dissertations (2009 - 2024)

Human reproduction in the female is a complex process requiring coordinated control of gonadotropic hormone signaling in a temporal, spatial and contextually defined manner. Paracrine and autocrine signaling between granulosa cells and oocytes of the developing ovarian follicle result in production of steroids, inhibin and growth factors that dictate maturation, ovulation or atresia. Follicular stimulating hormone (FSH) stimulation of the FSH receptor (FSHR), a G-protein coupled receptor (GPCR) is a key regulator of these processes. Recent developments in GPCR molecular and structural biology have helped define activation and signaling mechanisms that will aid in further defining the etiology of infertility …

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A Breast Cancer Stem Cell Model Created From Mmtv-Pymt Mice Applicable To Human Breast Cancer, Denise Grant Lanza Jan 2011

A Breast Cancer Stem Cell Model Created From Mmtv-Pymt Mice Applicable To Human Breast Cancer, Denise Grant Lanza

Legacy Theses & Dissertations (2009 - 2024)

Cancer stem cells are the seeds of tumor growth, but there are limited cell-based methods that exist to study the properties of these cells. To create a model of breast cancer stem cells, we isolated tumors from MMTV-PyMT mice. Two out of the four different cell types isolated survived in culture, CD44+CD24- and CD24+CD49f+CD44low. We found that we could initiate tumors with as few as 10 cells injected subcutaneously in the hind leg or orthotopically in the cleared fat pad with CD24+ cells. However, we could not initiate tumors with injection of CD24- cells. We found a requirement for TICs …

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The Role Of Trm9 In Stress Responses, Ashish Ravindra Patil Jan 2011

The Role Of Trm9 In Stress Responses, Ashish Ravindra Patil

Legacy Theses & Dissertations (2009 - 2024)

Cells need to respond appropriately to environmental changes in order to maintain homeostasis. The cellular response to an environmental stress is regulated at transcriptional, translational and post translational levels. The tRNA, which acts as an adaptor molecule between the mRNA and the protein, plays an important role in the translational regulation of cellular responses to stress and is one of the most heavily modified biomolecules. In Saccharomyces cerevisiae , the wobble uracil of the tRNA(3'-UCU-5') Arg, tRNA(3'-UUC-5') Glu and certain other specific tRNAs are modified to 5-methoxycarbonylmethyluridine (mcm5U) and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) residues by the tRNA methyltransferase 9 (Trm9). Modifications at …

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