Digital Commons Network^™

Chemoprevention Of Familial Melanoma, Vidhya Hariharan

Dissertations (6 month embargo)

Bleaching agents 4-tertiary butyl phenol (4-TBP) and monobenzyl ether of hydroquinone (MBEH) have been known to cause occupational vitiligo This project answers whether agents 4-TBP and MBEH can be used for prophylactic treatment of familial melanoma by being specifically toxic to melanocytes and activating an immune response against distant pigment cells. Cytotoxic experiments reveal that similar to 4-TBP, MBEH induces specific melanocyte death. To compare death pathways initiated by 4-TBP and MBEH, classical apoptotic hallmarks were evaluated in treated melanocytes. MBEH induced cell death without activating the caspase cascade or DNA fragmentation, showing that the death pathway is non-apoptotic. Release …

Health-Related Quality Of Life In The Gender, Race, And Clinical Experience Trial., Judith Feinberg, Michael Saag, Kathleen Squires, Judith Currier, Robert Ryan, Bruce Coate, Joseph Mrus

Division of Infectious Diseases and Environmental Medicine Faculty Papers

Background. We report health-related QoL (HRQoL) from GRACE (Gender, Race, And Clinical Experience) study by sex and race over 48 weeks. Methods. 429 treatment-experienced adults (HIV-1 RNA ≥ 1000 copies/mL) received darunavir/ritonavir 600/100 mg twice daily plus an appropriate background regimen. QoL was measured by the Functional Assessment of HIV Infection (FAHI) questionnaire. Results. 67% women and 77% men, including 67.4% black, 76.0% Hispanic, and 73.8% white patients, completed the trial. Baseline total FAHI scores were similar between sexes and races. Total FAHI of the entire population improved by Week 4 (P < .05); near-maximum changes obtained by Week 12 were maintained through Week 48. Women and black patients demonstrated larger improvements in total FAHI versus men, and Hispanic and white patients, respectively. Conclusion. HRQoL improved in all sex and racial/ethnic groups. Sex-based and race-based differences in improvements in FAHI subscales may provide insight into subtle differences of HIV-1 and treatment on HRQoL in different populations.

Today - August 26, 2011, Loma Linda University

TODAY

Inside this issue:

-- Loma Linda University Medical Center ranked No. 1 among Inland Empire hospitals
-- Twenty-seven LLUMC physicians included among U.S. News & World Report's Top Doctors
-- LLU advancement administrator receives Milton Trailblazer Award
-- Loma Linda University named among top 15 institutions for conferring degrees to minority students
-- Loma Linda University pharmacy residency program: a course of growth
-- Don Roth, General Conference representative, passes away
-- Innerweave: The Wholeness Story
-- Public health professor elected to nonprofit board of directors
-- Nutrition professor elected executive leader of California Dietetics Association
-- Loma Linda University …

Helminths Of Small Mammals (Erinaceomorpha, Soricomorpha, Chiroptera, Rodentia, And Lagomorpha) Of Mongolia, David S. Tinnin, Sumiya Ganzorig, Scott Lyell Gardner

Harold W. Manter Laboratory of Parasitology: Faculty Publications

Ninety-eight species of small mammal, excluding carnivores and ungulates, are currently recognized in the fauna of Mongolia. A list of species of helminths known to infect these species, both within Mongolia and across their range, is presented in an effort to aid in their study. A detailed bibliography of pertinent survey and related publications is provided.

The publication is the result of the Mongolian Vertebrate Parasite Project, made possible by NSF grants DEB-0717214, DBI-0646356, DBI-9631295, and DBI-9411976.

Altered Toll-Like Receptor 2-Mediated Endotoxin Tolerance Is Related To Diminished Interferon Beta Production., Ss Zaric, Wa Coulter, Ce Shelburne, Cr Fulton, Ms Zaric, A Scott, Mj Lappin, Dc Fitzgerald, Cr Irwin, Cc Taggart

Peninsula Dental School

Induction of endotoxin tolerance leads to a reduced inflammatory response after repeated challenge by LPS and is important for resolution of inflammation and prevention of tissue damage. Enterobacterial LPS is recognized by the TLR4 signaling complex, whereas LPS of some non-enterobacterial organisms is capable of signaling independently of TLR4 utilizing TLR2-mediated signal transduction instead. In this study we report that Porphyromonas gingivalis LPS, a TLR2 agonist, fails to induce a fully endotoxin tolerant state in a human monocytic cell line (THP-1) and mouse bone marrow-derived macrophages. In contrast to significantly decreased production of human IL-8 and TNF-α and, in mice, …

Vitamin A Supplements For Preventing Mortality, Illness, And Blindness In Children Aged Under 5: Systematic Review And Meta-Analysis, Evan Mayo-Wilson, Aamer Imdad, Kurt Herzer, Mohammad Yawar Yakoob, Zulfiqar Ahmed Bhutta

Woman and Child Health

Objective:To determine if vitamin A supplementation is associated with reductions in mortality and morbidity in children aged 6 months to 5 years.
Design: Systematic review and meta-analysis. Two reviewers independently assessed studies for inclusion. Data were double extracted, discrepancies were resolved by discussion. Meta-analyses were performed for mortality, illness, vision, and side effects. Data sources: Cochrane Central Register of Controlled Trials (CENTRAL) in the Cochrane Library, Medline, Embase, Global Health, Latin American and Caribbean Health Sciences, metaRegister of Controlled Trials, and African Index Medicus. Databases were searched to April 2010 without restriction by language or publication status.
Eligibility criteria …

Testing For A Descriptive And Injunctive Norm Interaction In Promoting Health Behavior, Robert E. Low

Master's Theses

Social norms-based interventions have demonstrated efficacy as tools for behavior change interventions. Nonetheless, there is some theoretical and empirical evidence that the efficacy of injunctive norms-based appeals can be undermined by their tendency to 1) arouse psychological reactance among participants, and 2) inadvertently imply that few others are completing the target behavior. The author hypothesizes that supplementing an injunctive appeal with evidence of a supporting descriptive norm will counteract these problematic tendencies. The present research describes a test of of this hypothesis in the context of an intervention to fight H1N1 on campus. Boxes of sanitizing keyboard wipes were placed …

Potential Applications Of Curcumin And Its Novel Synthetic Analogs And Nanotechnology-Based Formulations In Cancer Prevention And Therapy., Murielle Mimeault, Surinder K. Batra

Journal Articles: Biochemistry & Molecular Biology

Curcumin has attracted great attention in the therapeutic arsenal in clinical oncology due to its chemopreventive, antitumoral, radiosensibilizing and chemosensibilizing activities against various types of aggressive and recurrent cancers. These malignancies include leukemias, lymphomas, multiple myeloma, brain cancer, melanoma and skin, lung, prostate, breast, ovarian, liver, gastrointestinal, pancreatic and colorectal epithelial cancers. Curcumin mediates its anti-proliferative, anti-invasive and apoptotic effects on cancer cells, including cancer stem/progenitor cells and their progenies, through multiple molecular mechanisms. The oncogenic pathways inhibited by curcumin encompass the members of epidermal growth factor receptors (EGFR and erbB2), sonic hedgehog (SHH)/GLIs and Wnt/β-catenin and downstream signaling elements …

August 22, 2011 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Daniel Woods V. First Corr Med Inc

2011 Decisions

USDC for the District of Delaware

Human Pathogen Shown To Cause Disease In The Threatened Elkhorn Coral Acropora Palmata, Kathryn Patterson Sutherland, Sameera Shaban, Jessica L. Joyner, James W. Porter, Erin K. Lipp

Faculty Publications

Coral reefs are in severe decline. Infections by the human pathogen Serratia marcescens have contributed to precipitous losses in the common Caribbean elkhorn coral, Acropora palmata, culminating in its listing under the United States Endangered Species Act. During a 2003 outbreak of this coral disease, called acroporid serratiosis (APS), a unique strain of the pathogen, Serratia marcescens strain PDR60, was identified from diseased A. palmata, human wastewater, the non-host coral Siderastrea siderea and the corallivorous snail Coralliophila abbreviata. In order to examine humans as a source and other marine invertebrates as vectors and/or reservoirs of the APS pathogen, challenge experiments …

Alaska’S Health-Care Bill: $7.5 Billion And Climbing, Mark A. Foster, Oliver Scott Goldsmith

ISER Reports

Health-care spending for Alaskans reached about $7.5 billion in 2010. For comparison, that’s close to half the wellhead value of all the oil produced in Alaska that year. It’s also roughly equal to half the wages Alaskans collected in 2010. The state’s health-care spending has been rising fast, tripling since 1990 and jumping 40% just between 2005 and 2010—and at current trends it could double by 2020, reaching more than $14 billion. Here we report on who’s paying the bills, what we’re buying, what’s contributing to the growth, and other aspects of health-care spending. We conclude with a discussion of …

Letters To The Editor

Jefferson Journal of Psychiatry

Letters to the Editor to the Jefferson Journal of Psychiatry.

Bjc Today

BJC Today

No abstract provided.

Comparison Of Genomic And Proteomic Data In Recurrent Airway Obstruction Affected Horses Using Ingenuity Pathway Analysis, Julien Racine, Vinzenz Gerber, Marybeth Miskovic Feutz, C Paige Riley, Jiri Adamec, June E. Swinburne, Laurent Couetil

Department of Comparative Pathobiology Faculty Publications

Background: Recurrent airway obstruction (RAO) is a severe chronic respiratory disease affecting horses worldwide, though mostly in the Northern hemisphere. Environmental as well as genetic factors strongly influence the course and prognosis of the disease. Research has been focused on characterization of immunologic factors contributing to inflammatory responses, on genetic linkage analysis, and, more recently, on proteomic analysis of airway secretions from affected horses. The goal of this study was to investigate the interactions between eight candidate genes previously identified in a genetic linkage study and proteins expressed in bronchoalveolar lavage fluid (BALF) collected from healthy and RAO-affected horses. The …

Acute Coronary Syndrome, Diabetes And Hypertension : Oman Must Pay More Attention To Chronic Non-Communicable Diseases, Lamk Al-Lamki

Sultan Qaboos University Medical Journal

No abstract provided.

Shaken Baby Syndrome As A Form Of Abusive Head Trauma, Muna Al-Saadoon, Ibtisam B. Elnour, Anuradha

Sultan Qaboos University Medical Journal

Shaken baby syndrome (SBS) is a form of abuse that is characterised by brain injury. Because of the subtle and yet debilitating neurobehavioural impairment which ensues, SBS represents a diagnostic dilemma for attending clinicians. The situation is made worse by the young age of the affected child who may not be capable of explaining what happened. SBS has been reported in many parts of the world. To our knowledge, there is a dearth of literature on the topic from Arab/Islamic countries. This article attempts to shed light on the syndrome by reviewing information on the aetiology of SBS, as well …

The Abundance And Infection Status Of Anopheles Spp. Mosquitoes At Three Sites In Loudoun County, Northern Virginia, Priya Krishnan

Theses and Dissertations

Malaria is a re-emerging infectious disease with approximately half of the world's population at risk. In the US, since the 1950’s the Center for Disease Control (CDC) has been reporting between 1,000 and 1,500 cases of malaria every year. A majority of these cases were among US travellers and were attributed to Plasmodium falciparum. In August 2002, two cases of human malaria due to Plasmodium vivax were reported in Loudoun County, Northern Virginia. The Center for Disease Control and Prevention concluded that these cases were acquired locally. This was because of an absence of other risk factors such as international …

Correlates Of Self-Efficacy To Disclose Injection Drug Use To Hiv Primary Care Providers Among A Sample Of Hiv Seropositive Injection Drug Users, Yves Jeanty

Open Access Dissertations

This dissertation sought to identify correlates of perceived self-efficacy to disclose drug use to one’s HIV primary care provider (DISDR) among a sample of HIV-positive injection drug users (IDUs). Additionally the relationship between identified correlates and DISDR was evaluated to determine whether it persists longitudinally. Potential correlates consisted of individual characteristics (socio-demographic), health care service utilization, sex/drug use behaviors, and psychosocial characteristics. It was postulated that selected variables from these domains would be associated with DISDR. This study presents baseline and longitudinal data that suggest a positive association between self-efficacy to disclose injection drug use to one’s HIV primary care …

No Evidence Of Association Between Hiv-1 And Malaria In Populations With Low Hiv-1 Prevalence, Diego F. Cuadros, Adam J. Branscum, Gisela García-Ramos

Biology Faculty Publications

BACKGROUND: The geographic overlap between HIV-1 and malaria has generated much interest in their potential interactions. A variety of studies have evidenced a complex HIV-malaria interaction within individuals and populations that may have dramatic effects, but the causes and implications of this co-infection at the population level are still unclear. In a previous publication, we showed that the prevalence of malaria caused by the parasite Plasmodium falciparum is associated with HIV infection in eastern sub-Saharan Africa. To complement our knowledge of the HIV-malaria co-infection, the objective of this work was to assess the relationship between malaria and HIV prevalence in …

Distribution Records And Comments On Fleas In Southwestern South Dakota, Omer R. Larson, Steven G. Platt, Zannita Fast Horse, Thomas R. Rainwater, Stanlee M. Miller

Western North American Naturalist

From October 2003 through April 2006, we collected 565 fleas incidental to a distribution survey of mammals in southwestern South Dakota. Sixty-one specimens, representing 18 species of mammals, possessed 20 species of fleas. The geographic distributions of these flea species revealed 8 new records for the Black Hills and its adjacent grasslands. Four species—Megarthroglossus divisus, Stenoponia americana, Odontopsyllus dentatus, and Amaradix euphorbi—constitute new records for South Dakota, thus increasing the state’s known flea fauna to 42 species. Hunters, trappers, and field biologists should be aware that serosurveillance during the 1990s revealed the presence of sylvatic plague and tularemia …

Effect Of Variable Transmission Rate On The Dynamics Of Hiv In Sub-Saharan Africa, Diego F. Cuadros, Phillip H. Crowley, Ben Augustine, Sarah L. Stewart, Gisela García-Ramos

Biology Faculty Publications

BACKGROUND: The cause of the high HIV prevalence in sub-Saharan Africa is incompletely understood, with heterosexual penile-vaginal transmission proposed as the main mechanism. Heterosexual HIV transmission has been estimated to have a very low probability; but effects of cofactors that vary in space and time may substantially alter this pattern.

METHODS: To test the effect of individual variation in the HIV infectiousness generated by co-infection, we developed and analyzed a mathematical sexual network model that simulates the behavioral components of a population from Malawi, as well as the dynamics of HIV and the co-infection effect caused by other infectious diseases, …

Key Factors Influencing Educational Outcomes For Indigenous Students And Their Implications For Planning And Practice In The Nt., Jonathon Carapetis, Sven Silburn

2009 - 2019 ACER Research Conferences

This presentation considers the intrinsic link between health and education and the benefits of collaborative research for improving the education and life outcomes of Indigenous children. The Council of Australian Governments’ Overcoming Indigenous Disadvantage framework and the Closing the Gap generational strategy have resulted in significant new funding through a range of national partnership agreements to improve Indigenous child health, development and education. The focus of these reforms is consistent with the human development paradigm now advocated by international agencies such as UNICEF, WHO and OECD. They are also informed by recent advances in scientific knowledge regarding the developmental origins …

Targeting Of Triacylglycerol Synthase Gene For Tuberculosis Treatment (Con), Pappachan Kolattukudy, Jaiyanth Daniel, Vinod Dubey, Tatiana Sirakova

UCF Patents

Disclosed herein are novel methods for screening for compounds useful in treating or preventing tuberculosis. In exemplary embodiments, screening methods are based on the implementation or manipulation of triacylglycerol synthase like polypeptides or polynucleotides encoding the same. The methods are useful in identifying agents active against TB infection.

Rerooting The Evolutionary Tree Of Malaria Parasites, Diana C. Outlaw, Robert E. Ricklefs

Harold W. Manter Laboratory of Parasitology: Library Materials

Malaria parasites (Plasmodium spp.) have plagued humans for millennia. Less well known are related parasites (Haemosporida), with diverse life cycles and dipteran vectors that infect other vertebrates. Understanding the evolution of parasite life histories, including switches between hosts and vectors, depends on knowledge of evolutionary relationships among parasite lineages. In particular, inferences concerning time of origin and trait evolution require correct placement of the root of the evolutionary tree. Phylogenetic reconstructions of the diversification of malaria parasites from DNA sequences have suffered from uncertainty concerning outgroup taxa, limited taxon sampling, and selection on genes used to assess relationships. As …

The Holistic Complementary Structure Of Western Bio-Medicine And Traditional Healing And Achieving Complete Health, Candace Gail Oubre

USF Tampa Graduate Theses and Dissertations

Achieving complete health requires a deep understanding of complementary cultural competency sensitivity between physician and patient. This may include but is not limited to access to preventative health care resources, access to health educational resources and access to cultural healing resources, for example, shamans, Ayurvedic physicians, and herbal healers. Advocates of cultural competency emphasize great importance on knowledge of the patients' cultural background; however, the transcendence of this knowledge can be explained further through complementary cultural competency sensitivity. This is when the cultures of the physician and patient complement each other in terms of understanding what is in the patients' …

Characterizing The Distribution Of Planktonic Fecal Bacteria In The James River, Richmond, Virginia, John Furry

Theses and Dissertations

Surface waters containing fecal bacteria present significant public health risks. Understanding the sources of and factors affecting the distribution of fecal-indicating bacteria is necessary to predict potential illnesses more effectively. This thesis presents two studies on the distribution of fecal bacteria in the James River through Richmond, Virginia. Chapter 1 describes nearly 11 years of water quality, climate, and hydrologic data that occurred with changes in Escherichia coli concentrations, concluding that Richmond contributes significant quantities of fecal bacteria to the James River, and that the distribution of these bacteria varies seasonally. Chapter 2 details the development of Polymerase Chain Reaction …

Acer Research Conference Proceedings (2011)

2009 - 2019 ACER Research Conferences

The papers are also available individually from the session listing.

Development Of Computational Tools And Resources For Systems Biology Of Bacterial Pathogens, Ranjit Kumar

Theses and Dissertations

Bacterial pathogens are a major cause of diseases in human, agricultural plants and farm animals. Even after decades of research they remain a challenge to health care as they are known to rapidly evolve and develop resistance to the existing drugs. Systems biology is an emerging area of research where all of the components of the system, their interactions, and the dynamics can be studied in a comprehensive, quantitative, and integrative fashion to generate predictive models. When applied to bacterial pathogenesis, systems biology approaches will help identify potential novel molecular targets for drug discovery. A pre-requisite for conducting systems analysis …

Distribution Of Field Caught Mosquitoes From Laredo, Texas, Yvette Patricia Mendoza

Theses and Dissertations

Within the last decades, mosquito-borne viruses have re-emerged in the United States. These infectious viruses include Dengue, West Nile, St. Louis Encephalitis, and Chikungunya, just to name a few. Originating in sub-tropical and tropical regions, these viruses and the mosquitoes that transmit them know no borders. Laredo, Texas is a town which borders Nuevo Laredo, Tamaulipas, Mexico; an area that is known to have frequent outbreaks of the Dengue virus. Identifying the diversity of mosquito species and the abundance of mosquitoes in the City of Laredo is a key element in aiding local public health officials in disease surveillance. This …