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The Faculty Notebook, September 2011, Provost's Office

Faculty Notebook

The Faculty Notebook is published periodically by the Office of the Provost at Gettysburg College to bring to the attention of the campus community accomplishments and activities of academic interest. Faculty are encouraged to submit materials for consideration for publication to the Associate Provost for Faculty Development. Copies of this publication are available at the Office of the Provost.

Hiv And Concurrent Sexual Partnerships: Modelling The Role Of Coital Dilution, Larry Sawers, Alan G. Isaac, Eileen Stillwaggon

Economics Faculty Publications

Background: The concurrency hypothesis asserts that high prevalence of overlapping sexual partnerships explains extraordinarily high HIV levels in sub-Saharan Africa. Earlier simulation models show that the network effect of concurrency can increase HIV incidence, but those models do not account for the coital dilution effect (nonprimary partnerships have lower coital frequency than primary partnerships).

Methods: We modify the model of Eaton et al (AIDS and Behavior, September 2010) to incorporate coital dilution by assigning lower coital frequencies to non-primary partnerships. We parameterize coital dilution based on the empirical work of Morris et al (PLoS ONE, December …

When East Meets West : An Exploratory Study Of How Reiki Is Integrated Into Psychodynamic Practice, Kimberly Ann Winnegge

Theses, Dissertations, and Projects

This study was undertaken to explore the experience of mental health professionals who use Reiki in their therapeutic practice. Secondly, the study examined clinicians' perceptions of the efficacy of Reiki in a mental health setting. Recruitment letters were sent out via internet professional listservs to individuals who held both Reiki certification and mental health licensure. Sixteen participants, twelve social workers and four licensed mental health counselors, were interviewed regarding their views on the integration of Reiki within their practice. Narrative data was collected that described clinicians' personal experiences with Reiki, their practice and how they considered Reiki as a therapeutic …

Low Adherence To Outpatient Preoperative Methicillin-Resistant Staphylococcus Aureus Decolonization Therapy, Aisling R. Caffrey, B. Woodmansee, Nancy Crandall, Cynthia Tibert, Corinne Fielding, Dennis J. Mikolich, Michael P. Vezeridis, Kerry L. Laplante

Pharmacy Practice and Clinical Research Faculty Publications

No abstract provided.

I Can Sit But I’D Rather Stand: Commuter’S Experience Of Crowdedness And Fellow Passenger Behaviour In Carriages On Australian Metropolitan Trains, Lily Hirsch, Kirrilly Thompson

World Transit Research

For many people in Australia, crowding is a major issue and an unavoidable aspect of their daily rail commute. Australian passenger experiences, perceptions of, and their reactions to crowding are not well understood. To gain an understanding of passenger perceptions and tolerance of railway crowding and the impact of passenger behaviour on the crowding experience, qualitative (Stage 1) and quantitative (Stage 2) fieldwork was undertaken between 2009 and 2010 across the five metropolitan railways in Australia. Some results from Stage 1, a two-part qualitative study are given. This involved ethnographic participant observations on trains in five States and 20 focus …

Vegetation And The Importance Of Insecticide-Treated Target Siting For Control Of Glossina Fuscipes Fuscipes, Johan Esterhuizen, Basilio Njiru, Glyn A. Vale, Michael J. Lehane, Stephen J. Torr

All Peer-Reviewed Publications

Control of tsetse flies using insecticide-treated targets is often hampered by vegetation re-growth and encroachment which obscures a target and renders it less effective. Potentially this is of particular concern for the newly developed small targets (0.25 high × 0.5 m wide) which show promise for cost-efficient control of Palpalis group tsetse flies. Consequently the performance of a small target was investigated for Glossina fuscipes fuscipes in Kenya, when the target was obscured following the placement of vegetation to simulate various degrees of natural bush encroachment. Catches decreased significantly only when the target was obscured by more than 80%. Even …

Use Of Optimal Control Models To Predict Treatment Time For Managing Tick-Borne Disease, Holly D. Gaff, Elsa Schaefer, Suzanne Lenhart

Biological Sciences Faculty Publications

Tick-borne diseases have been on the rise recently, and correspondingly, there is an increased interest in implementing control measures to decrease the risk. Optimal control provides an ideal tool to identify the best method for reducing risk while accounting for the associated costs. Using a previously published model, a variety of frameworks are assessed to identify the key factors influencing mitigation strategies. The level and duration of tick-reducing efforts are key metrics for understanding the successful reduction in tick-borne disease incidence. The results show that the punctuated nature of the tick's life history plays a critical role in reducing risk …

Paleoamerican Diet, Migration And Morphology In Brazil: Archaeological Complexity Of The Earliest Americans, Sabine Eggers, Maria Parks, Gisela Grupe, Karl J. Reinhard

School of Natural Resources: Faculty Publications

During the early Holocene two main paleoamerican cultures thrived in Brazil: the Tradição Nordeste in the semi-desertic Sertão and the Tradição Itaparica in the high plains of the Planalto Central. Here we report on paleodietary singals of a Paleoamerican found in a third Brazilian ecological setting – a riverine shellmound, or sambaqui, located in the Atlantic forest. Most sambaquis are found along the coast. The peoples associated with them subsisted on marine resources. We are reporting a different situation from the oldest recorded riverine sambaqui, called Capelinha. Capelinha is a relatively small sambaqui established along a river 60 km from …

The Fecal Viral Flora Of Wild Rodents, Tung G. Phan, Beatrix Kapusinszky, Chunlin Wang, Robert K. Rose, Howard L. Lipton, Eric L. Delwart

Biological Sciences Faculty Publications

The frequent interactions of rodents with humans make them a common source of zoonotic infections. To obtain an initial unbiased measure of the viral diversity in the enteric tract of wild rodents we sequenced partially purified, randomly amplified viral RNA and DNA in the feces of 105 wild rodents (mouse, vole, and rat) collected in California and Virginia. We identified in decreasing frequency sequences related to the mammalian viruses families Circoviridae, Picobirnaviridae, Picornaviridae, Astroviridae, Parvoviridae, Papillomaviridae, Adenoviridae, and Coronaviridae. Seventeen small circular DNA genomes containing one or two replicase genes distantly related to the Circoviridae representing several potentially …

Aging And Sympathetic Neurotransmission In Two Strains Of Rats That Differ In Longevity And Immune Profiles, Sam David Perez

Loma Linda University Electronic Theses, Dissertations & Projects

Age-related changes in sympathetic neurotransmission in immune organs may be associated with immunosenescence; however no causal relationship has been established. From previous studies in Fischer rats (F344), we have found that during middle age, sympathetic nerve activity (SNA) rises in the spleen followed by a decline in noradrenergic (NA) innervation. Also, increased sympathetic signaling via betaadrenergic receptor (β-AR) and reduced proliferation of lymphocytes are evident with increasing age. Although SNA progressively rises with age, effects of age on sympathetic factors may be different across rat strains. If causal relationships exist between sympathetic activity and immune function, they may be related …

The -Omics Era- Toward A Systems-Level Understanding Of Streptomyces, Zhan Zhou, Jianying Gu, Yi-Ling Du, Yong-Quan Li, Yufeng Wang

Publications and Research

Streptomyces is a group of soil bacteria of medicinal, economic, ecological, and industrial importance. It is renowned for its complex biology in gene regulation, antibiotic production, morphological differentiation, and stress response. In this review, we provide an overview of the recent advances in Streptomyces biology inspired by -omics based high throughput technologies. In this post-genomic era, vast amounts of data have been integrated to provide significant new insights into the fundamental mechanisms of system control and regulation dynamics of Streptomyces.

Hand Hygiene Compliance Rate Among Healthcare Professionals, Yong H. Kim, Syed Z. Bukhari

Saudi Medical Journal

No abstract provided.

A Prospective Multicentre Observational Study To Evolve The Usefulness Of Group Of Homoeopathic Medicines In The Management Of Acute Tracheobronchitis, C Nayak, V Singh, H Singh, V Siddiqui, J Gupta, A Mishra, M Padmanabhan, S Sharma, Prasad

Indian Journal of Research in Homoeopathy

Abstract : Sn open multicentre clinical trial was aimed to evolve the usefulness of a group of homoeopathic medicines in the management of acute tracheobronchitis with regard to improvement in its symptom complex. Patients presenting coryza with irritable dry or productive cough, oppression chest and neutrophillic leucocytosis were enrolled in the study from October 2005 to September 2008. Severity of patients′ disease condition was evaluated as per tracheobronchitis symptom scale. Symptoms of disease as well as characteristic symptoms of individual patients were considered for selection of medicine from a group of 14 trial medicines. Selected medicine was prescribed in 6C …

Antagonistic Effects Of Cellular Poly(C) Binding Proteins On Vesicular Stomatitis Virus Gene Expression, Phat X. Dinh, Lalit Beura, Debasis Panda, Anshuman Das, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

Immunoprecipitation and subsequent mass spectrometry analysis of the cellular proteins from cells expressing the vesicular stomatitis virus (VSV) P protein identified the poly(C) binding protein 2 (PCBP2) as one of the P protein-interacting proteins. To investigate the role of PCBP2 in the viral life cycle, we examined the effects of depletion or overexpression of this protein on VSV growth. Small interfering RNA-mediated silencing of PCBP2 promoted VSV replication. Conversely, overexpression of PCBP2 in transfected cells suppressed VSV growth. Further studies revealed that PCBP2 negatively regulates overall viral mRNA accumulation and subsequent genome replication. Coimmunoprecipitation and immunofluorescence microscopic studies showed that …

Acute Fatty Liver Of Pregnancy: An Update On Mechanisms, Sathish Kumar Natarajan, Kavitha R. Thangaraj, Ashish Goel, C. E. Eapen, K. A. Balasubramanian, Anup Ramachandran

School of Veterinary and Biomedical Sciences: Faculty Publications

Acute fatty liver of pregnancy (AFLP), characterized by hepatic microvesicular steatosis, is a sudden catastrophic illness occurring almost exclusively in the third trimester of pregnancy. Defective fatty acid oxidation in the fetus has been shown to be associated with this disease. Since the placenta has the same genetic makeup as the fetus and as AFLP patients generally recover following delivery, we hypothesized that the placenta might be involved in pathogenesis of this disease. In an animal model of hepatic microvesicular steatosis (using sodium valproate), we found that microvesicular steatosis results in mitochondrial structural alterations and oxidative stress in subcellular organelles …

Group Size And Nest Spacing Affect Buggy Creek Virus (Togaviridae: Alphavirus) Infection In Nestling House Sparrows, Valerie A. Brown, Charles R. Brown

Papers in Ornithology

The transmission of parasites and pathogens among vertebrates often depends on host population size, host species diversity, and the extent of crowding among potential hosts, but little is known about how these variables apply to most vector-borne pathogens such as the arboviruses (arthropod-borne viruses). Buggy Creek virus (BCRV; Togaviridae: Alphavirus) is an RNA arbovirus transmitted by the swallow bug (Oeciacus vicarius) to the cliff swallow (Petrochelidon pyrrhonota) and the introduced house sparrow (Passer domesticus) that has recently invaded swallow nesting colonies. The virus has little impact on cliff swallows, but house sparrows are seriously …

Impact Of Ph1n1 Influenza A Infections On The Otolaryngology, Head And Neck Clinic During Hajj, 2009, Ameen Z. Alherabi

Saudi Medical Journal

OBJECTIVE: To examine the possible implications of the 2009 H1N1 influenza A (pandemic flu, pH1N1) on this religious gathering and provide a response plan for the Otolaryngology, Head and Neck (ENT) clinic during the Hajj pilgrimage. METHODS: This study was conducted between November and December 2009. All patients presenting to the ENT clinic at Al-Noor Specialist Hospital, Makkah, Kingdom of Saudi Arabia were recorded. Descriptive statistics were used to analyze the data. RESULTS: A total of 3087 patients were included (mean age 35±7.8 years), of which, 2114 were males (68.5%), and 973 females (31.5%, male to female gender ratio=2.17:1). Among …

Proteases In Malaria Parasites - A Phylogenomic Perspective, Hong Cai, Rui Kuang, Jianying Gu, Yufeng Wang

Publications and Research

Malaria continues to be one of the most devastating global health problems due to the high morbidity and mortality it causes in endemic regions. The search for new antimalarial targets is of high priority because of the increasing prevalence of drug resistance in malaria parasites. Malarial proteases constitute a class of promising therapeutic targets as they play important roles in the parasite life cycle and it is possible to design and screen for specific protease inhibitors. In this mini-review, we provide a phylogenomic overview of malarial proteases. An evolutionary perspective on the origin and divergence of these proteases will provide …

Chapter: The Advanced Practice Nurse In The Community, Kellie Smith, Molly A. Rose

College of Nursing Faculty Papers & Presentations

Objectives

After reading this chapter, the student should be able to do the following:

1. Briefly discuss the historical development of the roles of the advanced public health nurse and the nurse practitioner

2. Describe the educational requirements for population-focused advanced practice nurses

3. Discuss credentialing mechanisms in nursing as they relate to the role of the advanced practice nurse

4. Compare and contrast the various role functions of population-focused advanced practice nurses

5. Identify potential arenas of practice

6. Explore current issues and concerns related to practice

7. Identify five stressors that may affect nurses in expanded roles

Isolated Cryptococcal Osteomyelitis In An Immunocompetent Patient, Irfan Qadir, Farheen Ali, Umair Zafar Malik, Masood Umer

Department of Surgery Docs

bstract

Cryptococcosis is a rare infection in HIV-negative individuals. While the lungs and the central nervous system are most commonly infected, skeletal cryptococcosis is uncommon and isolated osteomyelitis due to Cryptococcus neoformans is quite rare. To our knowledge, only 47 cases of isolated cryptococcal osteomyelitis have been reported from 1974 to 2005. We report a case of isolatedcryptococcal osteomyelitis in an immunocompetent patient, who received 12 weeks of fluconazole with complete recovery.

Setting Research Priorities To Reduce Global Mortality From Childhood Pneumonia By 2015, Igor Rudan, Shams El Arifeen, Zulfiqar Ahmed Bhutta, Robert E. Black, Abdullah Brooks, Kit Yee Chan, Mickey Chopra, Trevor Duke, David Marsh, Antonio Pio, Eric A. F. Simoes, Giorgio Tamburlini, Evropi Theodoratou, Martin W. Weber, Cynthia G. Whitney, Harry Campbell, Shamim A. Qazi

Department of Paediatrics and Child Health

No abstract provided.

Sirolimus-Induced Pneumonitis Complicated By Pentamidine-Induced Phospholipidosis In A Renal Transplant Recipient: A Case Report., E J Filippone, J M Carson, R A Beckford, B C Jaffe, E Newman, B K Awsare, C Doria, J L Farber

Department of Medicine Faculty Papers

The proliferation signal inhibitors (PSIs)-sirolimus, everolimus, and temsirolimus-have been associated with a noninfectious pneumonitis characterized by lymphocytic alveolitis and bronciolitis obliterans with organizing pneumonia (BOOP). This condition usually occurs within the first year. Herein we presented a case of a deceased donor renal transplant with interstitial pneumonitis developing 6 years after a switch from tacrolimus to sirolimus due to chronic graft dysfunction. After the addition of intravenous pentamidine due to the suspicion of Pneumocystis pneumonia, there was marked clinical deterioration requiring intubation. Open lung biopsy revealed sirolimus-induced pulmonary toxicity (BOOP) with the additional finding of a drug-induced phospholipidosis (DIPL) that …

The 2007 Rift Valley Fever Outbreak In Sudan, Osama Ahmed Hassan, Clas Ahlm, Rosemary Sang, Magnus Evander

All Peer-Reviewed Publications

Rift Valley fever (RVF) is a neglected, emerging, mosquito-borne disease with severe negative impact on human and animal health and economy. RVF is caused by RVF virus (RVFV) affecting humans and a wide range of animals. The virus is transmitted through bites from mosquitoes and exposure to viremic blood, body fluids, or tissues of infected animals. During 2007 a large RVF outbreak occurred in Sudan with a total of 747 confirmed human cases including 230 deaths (case fatality 30.8%); although it has been estimated 75,000 were infected. It was most severe in White Nile, El Gezira, and Sennar states near …

Volume 49, Number 2: August 31, 2011, University Of North Dakota

University Letter Archive

No abstract provided.

Learning In Medical School: Relationships Among Achievement Goals And Approaches To Learning In Three Classes Of Medical Students, Pamela Devoe

Individual, Family, and Community Education ETDs

Medical student learning behaviors were examined in terms of achievement goals and approaches to learning. First, second, and third year medical students completed a Questionnaire composed of three extant inventories, the Achievement Goals Questionnaire (AGQ), the Metacognitive Awareness Inventory (MAI), and the Approaches to Learning and Studying Inventory (ALSI). Performance and demographic data were analyzed in terms of Questionnaire subscales. Of the three measures, two produced moderate to high reliability values. The MAI produced low reliability values and a high number of EFA factors resulting in discontinuation of analyses for that measure. Students holding mastery-approach achievement goals are more likely …

Characterization Of Vibrio Cholerae O1 El Tor Biotype Variant Clinical Isolates From Bangladesh And Haiti, Including A Molecular Genetic Analysis Of Virulence Genes, Mike S. Son, Christina J. Megli, Gabriela Kovacikova, Firdausi Qadri, Ronald K. Taylor

Dartmouth Scholarship

Vibrio cholerae serogroup O1, the causative agent of the diarrheal disease cholera, is divided into two biotypes: classical and El Tor. Both biotypes produce the major virulence factors toxin-coregulated pilus (TCP) and cholera toxin (CT). Although possessing genotypic and phenotypic differences, El Tor biotype strains displaying classical biotype traits have been reported and subsequently were dubbed El Tor variants. Of particular interest are reports of El Tor variants that produce various levels of CT, including levels typical of classical biotype strains. Here, we report the characterization of 10 clinical isolates from the International Centre for Diarrhoeal Disease Research, Bangladesh, and …

Wrap It Up : A Comparison Of The Health Belief Model And The Theory Of Planned Behavior, Erika Montanaro

Psychology ETDs

This study attempts to experimentally manipulate core constructs of the Health Belief Model (HBM) and the Theory of Planned Behavior (TPB) in order to increase condom use behavior. A direct comparison of the two models to determine the theory that best explains condom use behavior change will also be attempted. University of New Mexico psychology students (N = 280) completed measures on perceived susceptibility, severity, benefits, barriers, condom use self-efficacy, attitudes toward condoms, subjective norms, and perceived behavioral control. Next, they completed one of three randomly assigned computer-based interventions. 218 (77.8%) completed a behavioral assessment one month later. The TPB …

Generation Of Transgenic Human Soluble Amyloid Precursor Protein Alpha Expressing Mice, Jun Tan, William Nikolic, Huyan Hou

USF Patents

The present invention relates to a novel animal model for neurological degenerative diseases, especially autism, relating to overexpression of human secreted APP-alpha. This novel animal model exhibits several aspects of amyloidopathy. The present invention also relates to a method for producing the double transgenic animals, to cells and cell lines derived from these animals. Moreover, a method for the evaluation of the in vivo effects of a test compound on secreted APP-alpha expression and autism pathology in these animals is provided.

Structural Characterization Of Metal Binding In Metallo-Β-Lactamases Using X-Ray Absorption Spectroscopy, Robert M. Breece

Chemistry and Chemical Biology ETDs

In an effort to probe the structure and mechanism of metallo-β-lactamases, the metal-binding behaviors of several enzymes were studied using EXAFS (Extended X-ray Absorption Fine Structure). Three members of the metallo-β-lactamase subclass B1, BcII from Bacillus cereus, Bla2 from Bacillus anthracis and CcrA from Bacillus fragilis, were compared to examine metal-binding behavior within a subclass. Each system exhibits different metal-binding behavior including cooperative binding (BcII), sequential binding (CcrA), and differential binding between zinc(II) and cobalt(II) forms (Bla2). The metal-binding behavior of subclass B3 of L1 from Stenotrophomonas maltophilia was explored with RFQ (rapid-freeze quenched) EXAFS and site selective metal …

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