Digital Commons Network^™

Improving Service Through Just-In-Time Concept In A Dynamic Operational Environment, Kar Way Tan, Hoong Chuin Lau, Na Fu

Research Collection School Of Computing and Information Systems

This paper is concerned with the problem of Just-In-Time (JIT) job scheduling in a dynamic environment under uncertainty to attain timely service. We provide an approach, based on robust scheduling concepts, to analytically evaluate the expected cost of earliness and tardiness for each job and also the project. In addition, we search for a schedule execution policy with the minimum robust cost such that for a given risk level (epsilon), the actual realized schedule has (1 - epsilon) probability of completing with less than or equal to this robust cost. Our method is quite generic, and can be applied to …

Event-Related Potential Studies Of Post-Traumatic Stress Disorder: A Critical Review And Synthesis, Arash Javanbakht, Israel Liberzon, Alireza Amirsadri, Klevest Gjini, Nash N. Boutros

Wayne State University Associated BioMed Central Scholarship

Abstract

Despite the sparseness of the currently available data, there is accumulating evidence of information processing impairment in post-traumatic stress disorder (PTSD). Studies of event-related potentials (ERPs) are the main tool in real time examination of information processing. In this paper, we sought to critically review the ERP evidence of information processing abnormalities in patients with PTSD. We also examined the evidence supporting the existence of a relationship between ERP abnormalities and symptom profiles or severity in PTSD patients. An extensive Medline search was performed. Keywords included PTSD or post-traumatic stress disorder, electrophysiology or EEG, electrophysiology, P50, P100, N100, P2, …

Rhodococcus Equi Venous Catheter Infection: A Case Report And Review Of The Literature, Rosalinda Guerrero, Ashish Bhargava, Zeina Nahleh

Wayne State University Associated BioMed Central Scholarship

Abstract

Introduction

Rhodococcus equi is an animal pathogen that was initially isolated from horses and is being increasingly reported as a cause of infection in humans with impaired cellular immunity. However, this pathogen is underestimated as a challenging antagonist and is frequently considered to be a mere contaminant despite the potential for life-threatening infections. Most case reports have occurred in immunocompromised patients who have received organ transplants (for example kidney, heart, bone marrow) or those with human immunodeficiency virus infection. Infections often manifest as pulmonary involvement or soft tissue abscesses. Bacteremia related to R. equi infections of tunneled central venous …

Spatial-Temporal Analysis Of Non-Hodgkin Lymphoma In The Nci-Seer Nhl Case-Control Study, David C. Wheeler, Anneclaire J. De Roos, James R. Cerhan, Lindsay M. Morton, Richard Severson, Wendy Cozen, Mary H. Ward

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Exploring spatial-temporal patterns of disease incidence through cluster analysis identifies areas of significantly elevated or decreased risk, providing potential clues about disease risk factors. Little is known about the etiology of non-Hodgkin lymphoma (NHL), or the latency period that might be relevant for environmental exposures, and there are no published spatial-temporal cluster studies of NHL.

Methods

We conducted a population-based case-control study of NHL in four National Cancer Institute (NCI)-Surveillance, Epidemiology, and End Results (SEER) centers: Detroit, Iowa, Los Angeles, and Seattle during 1998-2000. Using 20-year residential histories, we used generalized additive models adjusted for known risk factors …

Clue: A Randomized Comparative Effectiveness Trial Of Iv Nicardipine Versus Labetalol Use In The Emergency Department, W Peacock, Joseph Varon, Brigitte M. Baumann, Pierre Borczuk, Chad M. Cannon, Abhinav Chandra, David M. Cline, Deborah Diercks, Brian Hiestand, A Hsu, Preeti Jois-Bilowich, Brian Kaminski, Philip Levy, Richard M. Nowak, Jon W. Schrock

Wayne State University Associated BioMed Central Scholarship

Abstract

Introduction

Our purpose was to compare the safety and efficacy of food and drug administration (FDA) recommended dosing of IV nicardipine versus IV labetalol for the management of acute hypertension.

Methods

Multicenter randomized clinical trial. Eligible patients had 2 systolic blood pressure (SBP) measures ≥180 mmHg and no contraindications to nicardipine or labetalol. Before randomization, the physician specified a target SBP ± 20 mmHg (the target range: TR). The primary endpoint was the percent of subjects meeting TR during the initial 30 minutes of treatment.

Results

Of 226 randomized patients, 110 received nicardipine and 116 labetalol. End organ damage …

Rad6b Acts Downstream Of Wnt Signaling To Stabilize Β-Catenin: Implications For A Novel Wnt/Β-Catenin Target, Brigitte Gerard, Larry Tait, Pratima Nangia-Makker, Malathy Pv Shekhar

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Aberrant Wnt/β-catenin signaling is associated with breast cancer even though genetic mutations in Wnt signaling components are rare. We have previously demonstrated that Rad6B, an ubiquitin conjugating enzyme, stabilizes β-catenin via polyubiqutin modifications that render β-catenin insensitive to proteasomal degradation. Rad6B is a transcriptional target of β-catenin, creating a positive feedback loop between Rad6B expression and β-catenin activation.

Methods

To isolate subpopulations expressing high or low Rad6B levels, we transfected MDA-MB-231 or WS-15 human breast cancer cells with ZsGreen fluorescent reporter vector in which the expression of ZsGreen was placed under the control of Rad6B promoter. ZsGreen^{high …}

Integrating An Internet-Mediated Walking Program Into Family Medicine Clinical Practice: A Pilot Feasibility Study, David E. Goodrich, Lorraine R. Buis, Adrienne W. Janney, Megan D. Ditty, Christine W. Krause, Kai Zheng, Ananda Sen, Victor J. Strecher, Michael L. Hess, John D. Piette, Caroline R. Richardson

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Regular participation in physical activity can prevent many chronic health conditions. Computerized self-management programs are effective clinical tools to support patient participation in physical activity. This pilot study sought to develop and evaluate an online interface for primary care providers to refer patients to an Internet-mediated walking program called Stepping Up to Health (SUH) and to monitor participant progress in the program.

Methods

In Phase I of the study, we recruited six pairs of physicians and medical assistants from two family practice clinics to assist with the design of a clinical interface. During Phase II, providers used the …

The Prevalence Of Waterpipe Tobacco Smoking Among The General And Specific Populations: A Systematic Review, Elie A. Akl, Sameer K. Gunukula, Sohaib Aleem, Rawad Obeid, Philippe Jaoude, Roland Honeine, Jihad Irani

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

The objective of this study was to systematically review the medical literature for the prevalence of waterpipe tobacco use among the general and specific populations.

Methods

We electronically searched MEDLINE, EMBASE, and the ISI the Web of Science. We selected studies using a two-stage duplicate and independent screening process. We included cohort studies and cross sectional studies assessing the prevalence of use of waterpipe in either the general population or a specific population of interest. Two reviewers used a standardized and pilot tested form to collect data from each eligible study using a duplicate and independent screening process. …

Histone Deacetylases (Hdacs) In Xpc Gene Silencing And Bladder Cancer, Xiaoxin S. Xu, Le Wang, Judith Abrams, Gan Wang

Wayne State University Associated BioMed Central Scholarship

Abstract

Bladder cancer is one of the most common malignancies and causes hundreds of thousands of deaths worldwide each year. Bladder cancer is strongly associated with exposure to environmental carcinogens. It is believed that DNA damage generated by environmental carcinogens and their metabolites causes development of bladder cancer. Nucleotide excision repair (NER) is the major DNA repair pathway for repairing bulk DNA damage generated by most environmental carcinogens, and XPC is a DNA damage recognition protein required for initiation of the NER process. Recent studies demonstrate reduced levels of XPC protein in tumors for a majority of bladder cancer patients. …

Phylogeny And Adaptive Evolution Of The Brain-Development Gene Microcephalin (Mcph1) In Cetaceans, Michael R. Mcgowen, Stephen H. Montgomery, Clay Clark, John Gatesy

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Representatives of Cetacea have the greatest absolute brain size among animals, and the largest relative brain size aside from humans. Despite this, genes implicated in the evolution of large brain size in primates have yet to be surveyed in cetaceans.

Results

We sequenced ~1240 basepairs of the brain development gene microcephalin (MCPH1) in 38 cetacean species. Alignments of these data and a published complete sequence from Tursiops truncatus with primate MCPH1 were utilized in phylogenetic analyses and to estimate ω (rate of nonsynonymous substitution/rate of synonymous substitution) using site and branch models of molecular evolution. We also tested …

Unfolded Protein Response In Cancer: The Physician's Perspective, Xuemei Li, Kezhong Zhang, Zihai Li

Wayne State University Associated BioMed Central Scholarship

Abstract

The unfolded protein response (UPR) is a cascade of intracellular stress signaling events in response to an accumulation of unfolded or misfolded proteins in the lumen of the endoplasmic reticulum (ER). Cancer cells are often exposed to hypoxia, nutrient starvation, oxidative stress and other metabolic dysregulation that cause ER stress and activation of the UPR. Depending on the duration and degree of ER stress, the UPR can provide either survival signals by activating adaptive and antiapoptotic pathways, or death signals by inducing cell death programs. Sustained induction or repression of UPR pharmacologically may thus have beneficial and therapeutic …

A Supermatrix Analysis Of Genomic, Morphological, And Paleontological Data From Crown Cetacea, Jonathan H. Geisler, Michael R. Mcgowen, Guang Yang, John Gatesy

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Cetacea (dolphins, porpoises, and whales) is a clade of aquatic species that includes the most massive, deepest diving, and largest brained mammals. Understanding the temporal pattern of diversification in the group as well as the evolution of cetacean anatomy and behavior requires a robust and well-resolved phylogenetic hypothesis. Although a large body of molecular data has accumulated over the past 20 years, DNA sequences of cetaceans have not been directly integrated with the rich, cetacean fossil record to reconcile discrepancies among molecular and morphological characters.

Results

We combined new nuclear DNA sequences, including segments of six genes (~2800 …

Bio::Phylo-Phyloinformatic Analysis Using Perl, Rutger A. Vos, Jason Caravas, Klaas Hartmann, Mark A. Jensen, Chase Miller

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Phyloinformatic analyses involve large amounts of data and metadata of complex structure. Collecting, processing, analyzing, visualizing and summarizing these data and metadata should be done in steps that can be automated and reproduced. This requires flexible, modular toolkits that can represent, manipulate and persist phylogenetic data and metadata as objects with programmable interfaces.

Results

This paper presents Bio::Phylo, a Perl5 toolkit for phyloinformatic analysis. It implements classes and methods that are compatible with the well-known BioPerl toolkit, but is independent from it (making it easy to install) and features a richer API and a data model that is …

Analysis Of Positional Candidate Genes In The Aaa1 Susceptibility Locus For Abdominal Aortic Aneurysms On Chromosome 19, John H. Lillvis, Yoshiki Kyo, Gerard Tromp, Guy M. Lenk, Ming Li, Qing Lu, Robert P. Igo Jr, Natzi Sakalihasan, Robert E. Ferrell, Charles M. Schworer, Zoran Gatalica, Susan Land, Helena Kuivaniemi

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Abdominal aortic aneurysm (AAA) is a complex disorder with multiple genetic risk factors. Using affected relative pair linkage analysis, we previously identified an AAA susceptibility locus on chromosome 19q13. This locus has been designated as the AAA1 susceptibility locus in the Online Mendelian Inheritance in Man (OMIM) database.

Methods

Nine candidate genes were selected from the AAA1 locus based on their function, as well as mRNA expression levels in the aorta. A sample of 394 cases and 419 controls was genotyped for 41 SNPs located in or around the selected nine candidate genes using the Illumina GoldenGate platform. …

Cloudaligner: A Fast And Full-Featured Mapreduce Based Tool For Sequence Mapping, Tung Nguyen, Weisong Shi, Douglas Ruden

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Research in genetics has developed rapidly recently due to the aid of next generation sequencing (NGS). However, massively-parallel NGS produces enormous amounts of data, which leads to storage, compatibility, scalability, and performance issues. The Cloud Computing and MapReduce framework, which utilizes hundreds or thousands of shared computers to map sequencing reads quickly and efficiently to reference genome sequences, appears to be a very promising solution for these issues. Consequently, it has been adopted by many organizations recently, and the initial results are very promising. However, since these are only initial steps toward this trend, the developed software does …

A Simulation Model Approach To Analysis Of The Business Case For Eliminating Health Care Disparities, David R. Nerenz, Yung-Wen Liu, Keoki L. Williams, Kaan Tunceli, Huiwen Zeng

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Purchasers can play an important role in eliminating racial and ethnic disparities in health care. A need exists to develop a compelling "business case" from the employer perspective to put, and keep, the issue of racial/ethnic disparities in health care on the quality improvement agenda for health plans and providers.

Methods

To illustrate a method for calculating an employer business case for disparity reduction and to compare the business case in two clinical areas, we conducted analyses of the direct (medical care costs paid by employers) and indirect (absenteeism, productivity) effects of eliminating known racial/ethnic disparities in mammography …

A Protein Network-Guided Screen For Cell Cycle Regulators In Drosophila, Stephen T. Guest, Jingkai Yu, Dongmei Liu, Julie A. Hines, Maria A. Kashat, Russell L. Finley Jr

Wayne State University Associated BioMed Central Scholarship

Abstract

Background

Large-scale RNAi-based screens are playing a critical role in defining sets of genes that regulate specific cellular processes. Numerous screens have been completed and in some cases more than one screen has examined the same cellular process, enabling a direct comparison of the genes identified in separate screens. Surprisingly, the overlap observed between the results of similar screens is low, suggesting that RNAi screens have relatively high levels of false positives, false negatives, or both.

Results

We re-examined genes that were identified in two previous RNAi-based cell cycle screens to identify potential false positives and false negatives. We …

2011-2012 Law School Catalog Addendum, Southern Methodist University, Dedman School Of Law

Law School Catalogs/Bulletins, 1926-present

No abstract provided.

Food Environment: Availability And Affordability Of Fruits, Vegetables, And Other Healthy Foods In Guilford County, North Carolina, Ismail Mintah

Theses

This study explores the built food environment in terms of food items availability and affordability in different types of stores and neighborhoods in Guilford County. A market basket list generated out of the USDA community food security toolkit was used to collect data on availability and prices of fruits and vegetables from three different stores types (Supermarkets, Grocery Stores, and Convenience Stores) in the county. Availability and affordability comparisons were undertaken by store type and income areas using (ANOVA) with a t-test. In general there were significant differences in availability and affordability of fruits and vegetables between supermarkets and grocery …

Factors Affecting Susceptibility Of Goats To Coccidia, Yaser Ahmed

Theses

Natural Resistance Associate Macrophages Protein one (NRAMP1) gene encodes a transmembrane protein that regulates divalent cation transport that hinders intracellular pathogen proliferation. The objective of this study was to determine how NRAMP1 expression and other factors may be associated with coccidia infections in goats. Clinically healthy Boer, Spanish, and Spanish-Boer cross goats (N=140) from the NCA&T Small ruminant unit were used. The FAMACHA© score, body condition score, body weight, and age were recorded. Fecal samples were evaluated for the levels of haemonchus eggs and coccidia oocytes using McMaster slides. Blood samples were evaluated for packed cell volume and …

The Effects Of Polyphenol Rich Peanut Skin Diets On Weight Gain, Lipid Profile, And Blood Chemistry In Rats, Erika Robinson Hayes

Theses

Peanut skin is a by-product of the peanut processing industry that is typically disposed. However, peanut skin contains significant amounts of protein, lipids, dietary fiber and is rich in antioxidants such as phenolics. The objectives of this study were to (1) evaluate the overall impact of peanut skin consumption on the growth of young lab rats; (2) investigate the effects of peanut skin consumption on blood plasma cholesterol profile in laboratory rats; and (3) evaluate the effect of peanut skin consumption on the functions of major animal organs by measuring the changes of related biomarkers and gross pathology. Twenty five …

Emission Enhancement Through Dual Donor Sensitization And Photo-Luminescine Properties Of Europium(Iii)And Terbium(Iii) -Terpyridine -Tetracyanoplatinate Complexes, Nuquie Glekeh Beedoe

Theses

Luminescence studies were conducted on tetracyanoplatinate complexes that contain up to four different ligands simultaneously, resulting in very complex structural features. Most of the complexes of (terpy)-Eu-platinum tetra cyanide complexes (terpy = terpyridine) crystallize with low one-, and two-dimensional structural types. The effects of anion variation on the intermolecular energy transfer (IET) mechanism are discussed in detail. Temperature dependent luminescence studies were also conducted on terbium based compounds that contain different ligands resulting in complex structural features. The system also displays dual donor feature where both the organic ligand (terpyridine) and the platinum tetracyanide (TCP) metal complex act as donors. …

Double-Layer Mesh Hernioplasty For Repairing Umbilical Hernias In 10 Goats*, Jose M. Vilar, Juan A. Corbera, Giuseppe Spinella

Turkish Journal of Veterinary & Animal Sciences

Umbilical hernias in goats are uncommon and can vary in their etiology and management. Hernioplasty can be done by closing the abdominal wall with a horizontal mattress pattern using absorbable sutures. However, larger defects (hernial ring size >3 cm) generally require the use of prosthetic materials that allow for a tension-free repair. In this study, 10 young female goats with umbilical hernias and hernial ring sizes ranging from 7-10 cm in width were treated using a double-layer polypropylene mesh. An ultrasonographic examination was performed to assess healing and connective tissue production.

Salt Equalizer, Vol. 2011, Issue 1, Society Of American Law Teachers

SALT Equalizer

Contents of This Issue:

Raquel Aldana & Steven W. Bender, Co-Presidents’ Column, at 1.

Hazel Weiser, Executive Director’s Column, at 1.

Ruben Garcia, 2011 San Francisco Dinner Is a Great Success; D.C. Is Next in 2012, at 5.

Ngai Pindell, SALT’s Teaching Conference a Tremendous Success, at 6.

Hazel Weiser, Have You Bought Your Copy of Vulnerable Populations and Transformative Law Teaching: A Critical Reader?, at 7.

Hazel Weiser, Breaking In: How to Get a Job in the Legal Academy, at 7.

Holly Maguigan, Leaders Sought to Serve on SALT’s Board of Governors, at 8.

Olympia Duhart, Membership Matters, …

2011 Treasurer's Report, Tennessee. Department Of Treasury

Treasurer's Reports

No abstract provided.

The Egg, Sperm, And Beyond: Gendered Assumptions In Gynecology Textbooks, Andrea Bertotti, Regina Rust

Sociology & Criminology Faculty Research

No abstract provided.

Alternatives To Potentially Inappropriate Medications For Use In E-Prescribing Software: Triggers And Treatment Algorithms, Anne L. Hume, J. Quilliam, Roberta Goldman, Charles Eaton, Kate L. Lapane

Pharmacy Practice and Clinical Research Faculty Publications

Objective: To describe the development of evidence-based electronic prescribing (e-prescribing) triggers and treatment algorithms for potentially inappropriate medications (PIMs) for older adults.

Design: Literature review, expert panel and focus group.

Setting: Primary care with access to e-prescribing systems.

Participants: Primary care physicians using e-prescribing systems receiving medication history.

Interventions: Standardised treatment algorithms for clinicians attempting to prescribe PIMs for older patients.

Main outcome measure: Development of 15 treatment algorithms suggesting alternative therapies.

Results: Evidence-based treatment algorithms were well received by primary care physicians. Providing alternatives to PIMs would make it easier for physicians …

The Role Of Zip Superfamily Of Metal Transporters In Chronic Diseases, Purification & Characterization Of A Bacterial Zip Transporter: Zupt., Iryna King

Wayne State University Theses

In mammals zinc is the second most abundant essential trace metal. Since Zn² is a small, hydrophilic, and a highly charged ion, it cannot be transported across the plasma or intracellular organelle membrane by passive diffusion. Different types of cells require a different constant concentration of zinc at all times. Presence of excess free Zn ions can be toxic to the cell. All cells must have tightly regulated homeostatic mechanisms in order to preserve healthy levels and proper compartmentalization of zinc. This is accomplished through the actions of specialized proteins that facilitate zinc uptake, efflux and compartmentalization. If the …

Probabilistic Models For Patient Scheduling, Adel Alaeddini

Wayne State University Theses

In spite of the success of theoretical appointment scheduling methods, there have been significant failures in practice primarily due to the rapid increase in the number of no-shows and cancelations from the individuals in recent times. These disruptions not only cause inconvenience to the management but also has a significant impact on the revenue, cost and resource utilization. In this research, we develop a hybrid probabilistic model based on logistic regression and Bayesian inference to predict the probability of no-shows in real-time. We also develop two novel non-sequential and sequential optimization models which can effectively use no-show probabilities for scheduling …

Temperament And Sex As Moderators Of The Relationship Between Maternal Smoke Exposure During Pregnancy And Child Externalizing Behaviors, Amy Beth Kohl

Wayne State University Theses

Cigarette smoking during pregnancy has been associated with negative child behavioral outcomes. Though many studies have found links between maternal smoking during pregnancy and behavior problems in children, few if any have looked into potential moderating factors of that relationship and few have examined the effects of second-hand smoking. This study examined child temperament at 6 months and sex as potential moderators of the relationship between maternal smoke exposure and both internalizing and externalizing behaviors at 24 month, 36 months and first grade. Both maternal smoking and maternal exposure to environmental tobacco smoke (ETS) were examined. Data for this study …