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Clement Clay Torbert And Alabama Law Reform Alabama Legal Issues Series, Tony A. Freyer, Paul M. Pruitt Jr., Volney Riser

Articles

No abstract provided.

Evaluation Of Rubella, Toxoplasma Gondii, And Cytomegalovirus Seroprevalences Among Pregnant Women In Denizli Province, Aysun Karabulut, Yusuf Polat, Meral Türk, Yasemi̇n Işik Balci

Turkish Journal of Medical Sciences

There is no national screening program for rubella, Toxoplasma gondii, and cytomegalovirus (CMV) infections for pregnant women in Turkey. The purpose of this study was to determine the prevalence of these infections among pregnant women in Denizli province, and to review seroprevalences reported from different regions of Turkey. Materials and methods: Between April 2008 and April 2009, 1268 women were investigated for rubella, 1102 for toxoplasma, and 1000 women for CMV seroprevalences in the first trimester of pregnancy. Toxoplasma and rubella IgM and IgG antibodies were assayed by the automated Vitros ECiQ system based on an immunometric technique. Cytomegalovirus IgM …

Prevalence Of Cutaneous Mycoses Among Workers, Ali Zarei Mahmoudabadi, Baharea Izadi

Turkish Journal of Medical Sciences

The aim of present study was to determine the prevalence of cutaneous mycoses in workers employed in different areas of the Ahvaz Jundishapur University of Medical Sciences. Materials and methods: In the present study 128 employees who held different positions (gardeners, lab cleaners, sanitary workers, repair workers, dishwashers, and cooks) at the Ahvaz Jundishapur University of Medical Sciences were studied. All workers were visited by a physician and 34 (26.6%) were suspected of having cutaneous fungal diseases. Several skin scraping and nail clipping samples were collected from the study participants. In addition, the Scotch Tape method was used for sampling …

Two Cases Of H1n1 Influenza Infection As The Initial Presentation Of Acute Leukemia, Leylagül Kaynar, Serdar Şivgin, Osman Başpinar, Fati̇h Kurnaz, Afra Yildirim, Gökhan Metan

Turkish Journal of Medical Sciences

Pandemic 2009 influenza A virus (H1N1) is a new influenza virus causing illness in human populations. Immunocompromised patients are at high risk for the acquisition of influenza and serious influenza-associated complications. However, there are no reports about patients with both newly diagnosed acute leukemia and H1N1 influenza infection. We reported 2 cases of previously healthy patients with H1N1 influenza infection as the initial presentation of acute leukemia.

A Comparison Of The Diagnostic Value Of 19-Gauge Histology And 22-Gauge Cytology Needles In Bronchoscopy For The Evaluation Of Endobronchial Lesions, Eli̇f Yilmazel Uçar, Mehmet Meral, Meti̇n Akgün, Sare Şi̇pal, Hasan Kaynar, Leyla Sağlam, Ali̇ Meti̇n Görgüner

Turkish Journal of Medical Sciences

To prospectively compare the sensitivity of Wang 22-gauge needle aspiration and 19-gauge needle aspiration with bronchial biopsy and determine whether there was difference between 22-gauge and 19-gauge needle aspirations in the diagnosis of endobronchial malignancies. Materials and methods: All patients (63 patients) in the study underwent fiberoptic bronchoscopy that included 22-gauge needle aspiration and 19-gauge needle aspiration. In 50 patients bronchial biopsy was done. The sensitivities of the individual techniques were compared. Results: Cancer was diagnosed in 48 patients by 22-gauge needle aspiration and 19-gauge needle aspiration, and in 43 patients by bronchial biopsy. The sensitivity of bronchial biopsy was …

Human Brucellosis In Turkey: A Review Of The Literature Between 1990 And 2009, Şebnem Çalik, Ayşe Deni̇z Gökengi̇n

Turkish Journal of Medical Sciences

Brucellosis is a systemic infection, which may involve any organ or system of the body. The aim of this study was a review of the literature related to human brucellosis in Turkey. Materials and methods: In order to find the published reports on this subject, 3 national databases (TÜBİTAK-ULAKBİM Turkish Medical Literature database, http://www.turkishmedline.com, http://medline.pleksus.com.tr) and 2 international databases [Index Medicus and Science Citation Index (SCI)-expanded] were searched. In addition to the databases, abstracts of congresses held by the Turkish Clinical Microbiology and Infectious Diseases Association and the Antibiotic and Chemotherapy Association were searched for reports about brucellosis. Results: The …

Piracetam Reverses Haloperidol-Induced Catalepsy In Mice, Omar Abdel Salam, Somaia Nada

Turkish Journal of Medical Sciences

To investigate the memory-enhancing drugs piracetam, vinpocetine, and ginkgo biloba for their ability to reduce catalepsy in mice treated with haloperidol. Haloperidol is a classic neuroleptic drug that induces motor abnormalities and cognitive impairment due to a blockade of dopamine D2 receptors in the striatum. Materials and methods: Catalepsy was induced by intraperitoneal haloperidol (2 mg/kg) administration. The drugs being tested were either administered intraperitoneally (IP) along with the dosage of haloperidol or 30 min prior to the introduction of the haloperidol. Catalepsy was measured using the bar test. Results: The administration of haloperidol (2 mg/kg, IP) resulted in significant …

The Prevalence Of Tuberculin Skin Test Positivity And The Effect Of Bcg Vaccinations On Tuberculin Induration Size In The Eastern Mediterranean Region Of Turkey, Ferda Kazanci, Ekrem Güler, Canan Eren Dağli, Mesut Gari̇pardiç, Mehmet Davutoğlu, Esen İspi̇roğlu, Hasan Çeti̇n Ekerbi̇çer, Hamza Karabi̇ber

Turkish Journal of Medical Sciences

To evaluate the prevalence of tuberculin skin test (TST) positivity in Kahramanmaraş and interpret the size of purified protein derivative (PPD) induration with respect to the number of Bacillus Calmette-Guerin (BCG) scars and other factors. Materials and methods: A total of 2979 school children between the ages of 7 and 17 years were evaluated. On the basis of socioeconomic levels, 11 schools were selected and categorized into 3 subgroups: schools in the suburbs of the city (Group 1), schools in the city center (Group 2), and private schools (Group 3). Children were injected with 5 TU/0.1 mL of PPD and …

A Quantitative Appraisal Of The Genuine Contribution Of Turkey And Turkish Universities To Science, Altan Onat

Turkish Journal of Medical Sciences

To assess quantitatively the cumulative and genuine contribution of Turkish universities to science in the main fields over the past 30 years. Materials and methods: In the Citation Reports section of the Web of Science, over 70 main scientific institutions were searched; and publications that received 60 or more citations by May 2010 were selected. Papers having more than a minor share by international authors were excluded. Results: Only 47 universities and 6 institutions generated articles that were cited >-60 times. These publications, numbering 541, received a total of 51.215 citations. Eight universities (İstanbul University, İstanbul Technical University, Hacettepe University, …

Why 'Democracy' And 'Drifter' Firms Can Have Abnormal Returns: The Joint Importance Of Corporate Governance And Abnormal Accruals In Separating Winners From Losers, Koon Boon Kee

Research Collection School Of Accountancy

No abstract provided.

Haiti Earthquake January 2010: What Actions And Policies Can The Government Of Haiti Implement To Improve Emergency Management Response, Steve Cohen

Master's Projects

In 2010, Haiti experienced a devastating earthquake that destroyed much of its capital city and the governmental offices that should have guided the response to the disaster. This research focuses on how Haiti can benefit from the Caribbean Disaster Management Agency’s standards for disaster resilience as it works to recover from the earthquake. Unfortunately, Haiti has long been dependent on assistance from non-governmental organizations due to its extreme poverty; its recovery is complicated by the need to integrate disaster assistance and on-going economic and social assistance into its development of a more resilient society.

Domestic Soldier: Kitty’S Secondary Post-Traumatic Stress Disorder In The Return Of The Soldier, Christina L. Huber, Heidi Potratz

The Oswald Review: An International Journal of Undergraduate Research and Criticism in the Discipline of English

No abstract provided.

Neurologic Improvement After Thoracic, Thoracolumbar, And Lumbar Spinal Cord (Conus Medullaris) Injuries, James S. Harrop, Md, Swetha Naroji, Mitchell G. Maltenfort, Phd, John K. Ratliff, Md, Stavropoula L. Tjoumakaris, Brian Frank, D. Greg Anderson, M.D., Todd Albert, Md, Alexander R. Vaccaro, Md, Phd

Department of Orthopaedic Surgery Faculty Papers

Study Design. Retrospective. Objective. With approximately 10,000 new spinal cord injury (SCI) patients in the United States each year, predicting public health outcomes is an important public health concern. Combining all regions of the spine in SCI trials may be misleading if the lumbar and sacral regions (conus) have a neurologic improvement at different rates than the thoracic or thoracolumbar spinal cord.

Summary of Background Data. Over a 10-year period between January 1995 to 2005, 1746 consecutive spinal injured patients were seen, evaluated, and treated through a level 1 trauma referral center. A retrospective analysis was performed on 150 patients …

Rural Hospital Ownership: Medical Service Provision, Market Mix, And Spillover Effects, Jill R. Horwitz, Austin Nichols

Articles

Objective. To test whether nonprofit, for-profit, or government hospital ownership affects medical service provision in rural hospital markets, either directly or through the spillover effects of ownership mix. Data Sources/Study Setting. Data are from the American Hospital Association, U.S. Census, CMS Healthcare Cost Report Information System and Prospective Payment System Minimum Data File, and primary data collection for geographic coordinates. The sample includes all nonfederal, general medical, and surgical hospitals located outside of metropolitan statistical areas and within the continental United States from 1988 to 2005. Study Design. We estimate multivariate regression models to examine the effects of (1) hospital …

Role Of Matrix Metalloproteinase 3-Mediated Alpha-Synuclein Cleavage In Dopaminergic Cell Death, Dong-Hee Choi, Youn-Jung Kim, Young-Gun Kim, Tong H. Joh, M. Flint Beal, Yoon-Seong Kim

Faculty Bibliography 2010s

Evidence suggests that the C-terminal truncation of alpha-synuclein is equally important as aggregation of alpha-synuclein in Parkinson disease (PD). Our previous results showed that an endopeptidase, matrix metalloproteinase-3 (MMP3), was induced and activated in dopaminergic (DA) cells upon stress conditions. Here, we report that MMP3 cleaved alpha-synuclein in vitro and in vivo and that alpha-synuclein and MMP3 were co-localized in Lewy bodies (LB) in the postmortem brains of PD patients. Incubation of alpha-synuclein with the catalytic domain of MMP3 (cMMP3) resulted in generation of several peptides, and the peptide profiles of WT alpha-synuclein (WTsyn) and A53T mutant (A53Tsyn) were different. …

Fda Recalls Not As Alarming As They Seem, Jason T. Connor, Roger J. Lewis, Donald A. Berry, Scott M. Berry

Faculty Bibliography 2010s

No abstract provided.

A Functional Nuclear Epidermal Growth Factor Receptor, Src And Stat3 Heteromeric Complex In Pancreatic Cancer Cells, Soumya Jaganathan, Peibin Yue, David C. Paladino, Jelena Bogdanovic, Qun Huo, James Turkson

Faculty Bibliography 2010s

Evidence is presented for the nuclear presence of a functional heteromeric complex of epidermal growth factor (EGFR), Src and the Signal Transducer and Activator of Transcription (Stat) 3 proteins in pancreatic cancer cells. Stat3 remains nuclear and associated with Src or EGFR, respectively, upon the siRNA knockdown of EGFR or Src, demonstrating the resistance of the complex to the modulation of EGFR or Src alone. Significantly, chromatin immunoprecipitation (ChIP) analyses reveal the nuclear EGFR, Src and Stat3 complex is bound to the c-Myc promoter. The siRNA knockdown of EGFR or Src, or the pharmacological inhibition of Stat3 activity only marginally …

Epigenetic Regulation Of Microrna Genes And The Role Of Mir-34b In Cell Invasion And Motility In Human Melanoma, Joseph Mazar, Divya Khaitan, Dan Deblasio, Cuncong Zhong, Subramaniam S. Govindarajan, Sharmila Kopanathi, Shaojie Zhang, Animesh Ray, Ranjan J. Perera

Faculty Bibliography 2010s

Invasive melanoma is the most lethal form of skin cancer. The treatment of melanoma-derived cell lines with 5-aza-2'-deoxycytidine (5-Aza-dC) markedly increases the expression of several miRNAs, suggesting that the miRNA-encoding genes might be epigenetically regulated, either directly or indirectly, by DNA methylation. We have identified a group of epigenetically regulated miRNA genes in melanoma cells, and have confirmed that the upstream CpG island sequences of several such miRNA genes are hypermethylated in cell lines derived from different stages of melanoma, but not in melanocytes and keratinocytes. We used direct DNA bisulfite and immunoprecipitated DNA (Methyl-DIP) to identify changes in CpG …

Distinctive Left-Sided Distribution Of Adrenergic-Derived Cells In The Adult Mouse Heart, Kingsley Osuala, Kathleen Telusma, Saad M. Khan, Shandong Wu, Mubarak Shah, Candice Baker, Sabikha Alam, Ibrahim Abukenda, Aura Fuentes, Hani B. Seifein, Steven N. Ebert

Faculty Bibliography 2010s

Adrenaline and noradrenaline are produced within the heart from neuronal and non-neuronal sources. These adrenergic hormones have profound effects on cardiovascular development and function, yet relatively little information is available about the specific tissue distribution of adrenergic cells within the adult heart. The purpose of the present study was to define the anatomical localization of cells derived from an adrenergic lineage within the adult heart. To accomplish this, we performed genetic fate-mapping experiments where mice with the cre-recombinase (Cre) gene inserted into the phenylethanolamine-n-methyltransferase (Pnmt) locus were cross-mated with homozygous Rosa26 reporter (R26R) mice. Because Pnmt serves as a marker …

Modulation Of Toxin Stability By 4-Phenylbutyric Acid And Negatively Charged Phospholipids, Supriyo Ray, Michael Taylor, Mansfield Burlingame, Suren A. Tatulian, Ken Teter

Faculty Bibliography 2010s

AB toxins such as ricin and cholera toxin (CT) consist of an enzymatic A domain and a receptor-binding B domain. After endocytosis of the surface-bound toxin, both ricin and CT are transported by vesicle carriers to the endoplasmic reticulum (ER). The A subunit then dissociates from its holotoxin, unfolds, and crosses the ER membrane to reach its cytosolic target. Since protein unfolding at physiological temperature and neutral pH allows the dissociated A chain to attain a translocation-competent state for export to the cytosol, the underlying regulatory mechanisms of toxin unfolding are of paramount biological interest. Here we report a biophysical …

Preformulation And Stability In Biological Fluids Of The Retrocyclin Rc-101, A Potential Anti-Hiv Topical Microbicide, Alexandra B. Sassi, Katherine E. Bunge, Brian L. Hood, Thomas P. Conrads, Alexander M. Cole, Phalguni Gupta, Lisa C. Rohan

Faculty Bibliography 2010s

Background: RC-101, a cationic peptide retrocyclin analog, has in vitro activity against HIV-1. Peptide drugs are commonly prone to conformational changes, oxidation and hydrolysis when exposed to excipients in a formulation or biological fluids in the body, this can affect product efficacy. We aimed to investigate RC-101 stability under several conditions including the presence of human vaginal fluids (HVF), enabling the efficient design of a safe and effective microbicide product. Stability studies (temperature, pH, and oxidation) were performed by HPLC, Circular Dichroism, and Mass Spectrometry (LC-MS/MS). Additionally, the effect of HVF on formulated RC-101 was evaluated with fluids collected from …

Inactivation And Reactivation Of The Mitochondrial Alpha-Ketoglutarate Dehydrogenase Complex, Qingli Shi, Hui Xu, Haiqiang Yu, Nawei Zhang, Yaozu Ye, Alvaro G. Estevez, Haiteng Deng, Gary E. Gibson

Faculty Bibliography 2010s

Reduced brain metabolism is an invariant feature of Alzheimer Disease (AD) that is highly correlated to the decline in brain functions. Decreased activities of key tricarboxylic acid cycle (TCA) cycle enzymes may underlie this abnormality and are highly correlated to the clinical state of the patient. The activity of the alpha-ketoglutarate dehydrogenase complex (KGDHC), an arguably rate-limiting enzyme of the TCA cycle, declines with AD, but the mechanism of inactivation and whether it can be reversed remains unknown. KGDHC consists of multiple copies of three subunits. KGDHC is sensitive to oxidative stress, which is pervasive in AD brain. The present …

Determination Of An Optimal Dose Of Medetomidine-Ketamine-Buprenorphine For Anaesthesia In The Cape Ground Squirrel (Xerus Inauris), K. E. Joubert, T. Serfontein, M. Scantlebury, M. B. Manjerovic, P. W. Bateman, N. C. Bennett, J. M. Waterman

Faculty Bibliography 2010s

The optimal dose of medetomidine-ketamine-buprenorphine was determined in 25 Cape ground squirrels (Xerus inauris) undergoing surgical implantation of a temperature logger into the abdominal cavity. At the end of anaesthesia, the squirrels were given atipamezole intramuscularly to reverse the effects of medetomidine. The mean dose of medetomidine was 67.6 +/- 9.4 mu g/kg, keta mine 13.6 +/- 1.9 mg/kg and buprenorphine 0.5 +/- 0.06 mu g/kg. Induction time was 3.1 +/- 1.4 min. This produced surgical anaesthesia for 21 +/- 4.2 min. Atipamezole 232 +/- 92 mu g/kg produced a rapid recovery. Squirrels were sternally recumbent in 3.5 +/- 2.2 …

A Therapeutic Chemical Chaperone Inhibits Cholera Intoxication And Unfolding/Translocation Of The Cholera Toxin A1 Subunit, Michael Taylor, Tuhina Banerjee, Fernando Navarro-Garcia, Jazmin Huerta, Shane Massey, Mansfield Burlingame, Abhay H. Pande, Suren A. Tatulian, Ken Teter

Faculty Bibliography 2010s

Cholera toxin (CT) travels as an intact AB(5) protein toxin from the cell surface to the endoplasmic reticulum (ER) of an intoxicated cell. In the ER, the catalytic A1 subunit dissociates from the rest of the toxin. Translocation of CTA1 from the ER to the cytosol is then facilitated by the quality control mechanism of ER-associated degradation (ERAD). Thermal instability in the isolated CTA1 subunit generates an unfolded toxin conformation that acts as the trigger for ERAD-mediated translocation to the cytosol. In this work, we show by circular dichroism and fluorescence spectroscopy that exposure to 4-phenylbutyric acid (PBA) inhibited the …

Elliptical Exercise Improves Fatigue Ratings And Quality Of Life In Patients With Multiple Sclerosis, Jessie M. Huisinga, Mary Filipi, Nikolaos Stergiou

Journal Articles

Fatigue, reduced quality of life (QOL), and lower physical activity levels are commonly reported in patients with multiple sclerosis (MS). This study evaluated the effects of elliptical exercise on fatigue and QOL reports in patients with MS. Patients with MS (n = 26) completed the Fatigue Severity Scale (FSS), the Modified Fatigue Impact Scale (MFIS), and the Medical Outcomes Study 36-Item Short Form Health Survey (SF-36) before and after completing 15 elliptical exercise training sessions. Changes in fatigue and QOL were assessed based on any changes in the fatigue and SF-36 questionnaires, and correlations between changes in each of the …

Walking Abnormalities Are Associated With Copd: An Investigation Of The Nhanes Iii Dataset, Jenna M. Yentes, Harlan Sayles, Jane Meza, David M. Mannino, Stephen I. Rennard, Nikolaos Stergiou

Journal Articles

Research on the peripheral effects of COPD has focused on physiological and structural changes. However, different from muscular weakness or decreased physical activity, mechanical abnormalities of the muscular system, e.g. walking, have yet to be investigated. Our purpose was to utilize the National Health and Nutritional Examination Survey (NHANES) dataset to determine whether walking abnormalities are associated with COPD severity. To determine if walking abnormalities were independently associated with COPD severity, our analysis aimed to investigate the association of physical activity levels with COPD severity and with walking abnormalities. The NHANES III dataset that contains data for 31,000 persons that …

Weathering The Storm: Adolescent Girls And Climate Change, Anita Swarup, Irene Dankelman, Kanwal Ahluwalia, Kelly Hawrylyshyn

East Africa

The impacts of climate change, whether they are gradual changes in agriculture and living conditions or the more cataclysmic effects of a cyclone or flood, are different for different populations. But inevitably children everywhere are badly affected, and girls in particular bear the greater burden. Their lives, prospects and human rights must be better protected. We will never achieve climate justice without addressing the gender dimensions of climate change, and girls themselves, their skills, knowledge and energy, must be part of the search for solutions. During UNFCCC’s COP-16 in Cancún, Mexico, in December 2010 the girls who attended demonstrated their …

Second National Communication Of Seychelles, Government Of Seychelles

East Africa

The Initial National Communication of Seychelles which was submitted to UNFCCC in October 2000 was important in bringing attention to climate change issues in Seychelles; it had nonetheless some limitations. It focused primarily on reporting under the Convention and that strategic opportunities for feeding into national development were not fully exploited and there was limited participation of stakeholders from public and private sectors. The Investigations were essentially academic in nature; hence of limited relevance to policy decision making, for instance the climate risk management issue.

Women In Positions Of Influence: Exploring The Journeys Of Female Community Leaders, Mary Pflanz

Department of Educational Administration: Dissertations, Theses, and Student Research

Although the leadership norm continues to be male-oriented, more women are occupying positions of leadership in our society. The prevalent question has shifted from whether or not women can lead to how effectively they lead. To better understand the effectiveness of female community leaders, this qualitative research study explores the common features in the paths of women who have attained leadership positions. The stories of these women were derived by conducting ten interviews with women who are in positions of leadership within their communities. The interviews used open-ended questions to elicit personal responses from the interviewees, and phenomenological methods were …

Anterior-Posterior And Medial-Lateral Control Of Sway In Infants During Sitting Acquisition Does Not Become Adult-Like, Fabien Cignetti, Anastasia Kyvelidou, Regina T. Harbourne, Nikolaos Stergiou

Journal Articles

We examined (1) how sitting postural control in infants develops in the anterior–posterior (A/P) and medial–lateral (M/L) directions of sway, and (2) whether this control is already adult-like during the late phase of infant's sitting acquisition. COP data were acquired from 14 healthy infants (from the onset of sitting until independent sitting) and 21 healthy adults while sitting on a force platform. Attractor dimensionality (CoD: correlation dimension), attractor predictability (LyE: largest Lyapunov exponent), and sway variability (RMS: root-mean square) were calculated from the COP data to evaluate postural control. In the A/P direction, sitting was mastered by the infants by …