Digital Commons Network^™

Functional Effects Of Cyp1a2, Nat1, And Nat2 Genetic Variants In Nucleotide Excision Repair-Deficient Human Fibroblasts : Implications For Toxicological Risk From Environmental Arylamines., Carmine Simone Leggett

Electronic Theses and Dissertations

Arylamine N-acetyltransferase 1 (NAT1) and 2 (NAT2) catalyze the detoxification and/or activation of aromatic and heterocyclic amine carcinogens by two pathways. This metabolism reaction can lead to the detoxification by Nacetylation, or bioactivation by a-acetylation often preceded by CYP450 hydroxylation. Human NAT2 polymorphisms are characterized by rapid, intermediate, and slow acetylator phenotypes, thus resulting in differences in the rate of arylamine metabolism and consequently cancer risk. We have constructed nucleotide excision repair-deficient human cell model expressing human CYP1A2 and human NAT1and NAT2 in order to investigate carcinogen metabolism and cancer susceptibility in human cells. In this study we introduce the …

Reverse Transfer Students : Characteristics, Motivations, And Implications., Kathryn Elizabeth Lowrey 1957-

Electronic Theses and Dissertations

The reverse transfer literature contains studies investigating the demographic characteristics of postsecondary students that attended a community college after attending a four-year institution, and their proportion in the community college student population. A few researchers have investigated reverse transfer student motives for enrolling in the two-year college. However, the literature is lacking studies exploring the intentions of reverse transfer students to complete their programs of study at the community college, and how these intentions impact retention and completion measures of effectiveness at the community college. The purpose of this study was to examine reverse transfer student demographic characteristics, education background, …

Measuring University Students' Perceptions Of Characteristics Of Ideal University Instructor In Saudi Arabia And The United States: An Application Of Nonparametric Item Response Theory Study, Hesham Yahya Aljubaily

Dissertations

No abstract provided.

Perceived Parenting Style And Its Relationship To Hopefulness, Happiness, And Optimism In A College Student Sample, Sarah Griess

Dissertations

No abstract provided.

Implementing A New Curriculum: Reflections Of A Physical Education Teacher, Matthew Daniel Madden

Dissertations

No abstract provided.

Process, Perspectives, And Benefits Of Animal Assisted Therapy, Laurie Christine Paquette

Dissertations

The purpose of this study was to understand mental health/human services professionals' processes, perspectives, and beliefs about animal assisted therapy. There has been an increase in the use of animals in therapy over the last 40 years. Animals are being used to help clients with a variety of mental and physical problems. In 2007, Division 17 of the American Psychological Association established Section 13, Animal-Human Interaction: Research and Practice, to educate professionals and scholars on understanding animal-human interaction in relation to counseling psychology. Six licensed master's and doctoral level professionals were selected based on their current use of animals in …

Unitive/Mystical Experiences And Life Changes, Susan F. Schneeberger

Dissertations

The purpose of this study was to explore life changes in beliefs, philosophy, and behavior in individuals who reported having a unitive/mystical experience (U/ME). A U/ME is a generally spontaneously occurring state of consciousness characterized by a sense of unity or "oneness" that transcends sensory or cognitive apprehension (Stace, 1960). There is often an ineffable certainty that an ultimate truth has been perceived and can be applied to one's life. The experience may be accompanied or followed by feelings of joy and bliss. One hundred sixty adults from a broad range of demographic characteristics participated in a one-time webbased survey. …

The Culture Care Meaning Of Comfort For Ethnically Diverse Pre-Licensure Baccalaureate Nursing Students In The Educational Setting, Lynne K. Zajac

Dissertations

The nursing profession is calling for enhanced diversity within the ranks of registered nurses to meet the health care needs of an increasingly diverse society. Nursing education is faced with the challenge of retaining ethnically diverse nursing students. Students who are ethnically diverse face unique challenges in addition to the universal stressors of nursing school. The experience of comfort as theorized by Kolcaba may provide ease, relief, and transcendence of the discomfort experienced by diverse nursing students. This ethnonursing research study utilizing Leininger's Culture Care Theory is an in-depth examination of the culture care meaning of comfort for ethnically diverse …

The Issue Of Intent In The Genocide Convention And Its Effect On The Prevention And Punishment Of The Crime Of Genocide: Toward A Knowledge-Based Approach, Katherine Goldsmith

Genocide Studies and Prevention: An International Journal

Since the Genocide Convention was created in 1948, its effectiveness has been hindered by debates on what the definition actually means. It has been widely accepted that the meaning of ‘‘intent,’’ within the Genocide Convention, refers to specific or special intent, dolus specialis. However, as more trials have taken place, creating more understanding of the crime of genocide, the linking of dolus specialis with the intent definition, that was so easily accepted at the first genocide trial (Akayesu at the International Criminal Tribunal for Rwanda [ICTR]), has been repeatedly put into question. The new approach being put forward as the …

Memory Controversies In Post-Genocide Rwanda: Implications For Peacebuilding, Elisabeth King

Genocide Studies and Prevention: An International Journal

Intrastate wars and genocides result in devastating losses and leave deep and lasting scars on those who survive. Making space for civilians to share their experiences of violence and to have them publicly acknowledged—especially by their own governments—can be important parts of (re)knitting the social fabric. This article focuses on the experiences of ordinary Rwandans during and after their country’s civil war and genocide. It is centered on excerpts from a series of field interviews and highlights Rwandans’ memories in their own words. This article contrasts this cross-section of civilian narratives with the official memories of violence that the national …

A Study On Masquerade Detection, Lin Huang

Master's Projects

In modern computer systems, usernames and passwords have been by far the most common forms of authentication. A security system relying only on password protection is defenseless when the passwords of legitimate users are compromised. A masquerader can impersonate a legitimate user by using a compromised password.

An intrusion detection system (IDS) can provide an additional level of protection for a security system by inspecting user behavior. In terms of detection techniques, there are two types of IDSs: signature-based detection and anomaly-based detection. An anomaly-based intrusion detection technique consists of two steps: 1) creating a normal behavior model for legitimate …

The Distribution And Reproductive Success Of The Western Snowy Plover Along The Oregon Coast - 2010, David J. Lauten, Kathleen J. Castelein, J. Daniel Farrar, Adam A. Kotaich, Eleanor P. Gaines

Institute for Natural Resources Publications

From 8 April – 27 September 2010 we monitored the distribution, abundance and productivity of the federally Threatened Western Snowy Plover (Charadrius alexandrinus nivosus) along the Oregon coast. From north to south, we surveyed and monitored plover activity at Sutton Beach, Siltcoos River estuary, the Dunes Overlook, North Tahkenitch Creek, Tenmile Creek, Coos Bay North Spit, Bandon Beach, New River, and Floras Lake. Our objectives for the Oregon coastal population in 2010 were to: 1) estimate the size of the adult Snowy Plover population, 2) locate plover nests, 3) continue selective use of mini-exclosures (MEs) to protect nests …

Characterizing Dietary Intake And Physical Activity Affecting Weight Gain In Kidney Transplant Recipients, Connie Klopfenstein Cupples

Theses and Dissertations (ETD)

Weight gain following kidney transplant is a significant problem with 50 to 90% of kidney transplant recipients gaining weight. Potential factors leading to weight gain following kidney transplantation have been thought to include a change in lifestyle such asdietary intake and physical activity, along with the use of immunosuppressant medications to preserve the newly implanted organ. Other influences affecting weight gain include genetic determinates such as age, gender and race. There is little data to confirm which of these factors may indeed lead to weight gain and obesity. The purpose of this study was to examine dietary intake and physical …

D2r Dopamine Receptor Mediates Changes In Dual Specificity Phosphatase Expression In A Small Cell Lung Cancer Cell Line, Scott Lemar Lattimer

Theses and Dissertations (ETD)

Bromocriptine, a D2 dopamine receptor (D2R) agonist, is used clinically as a treatment for pituitary tumors of a lactotroph origin. Many questions remain unanswered about the mechanism of this effect. The antiproliferative effect has not been demonstrated in DMS 53 cell line, a Small Cell Lung Cancer (SCLC). In this thesis, we have shown that treatment with NPA (N‑propylnorapomorphine), a dopamine receptor agonist inhibits ERK phosphorylation and proliferation in DMS 53 cells. NPA treatment causes significant increases in DUSP‑1 (MKP‑1), DUSP‑4 (MKP‑2) and DUSP5 mRNA. NPA treatment also correlates with increases in DUSP5 (hVHR3) protein visualized using Western Blot. These …

The Colby Echo (2010-12-01), Colby College

The Colby Echo

Published by the students of Colby College since 1877, The Colby Echo is the weekly, editorially independent student-run newspaper of Colby College in Waterville, Maine. Published monthly, 1877-1886; semi-monthly, 1886-1897; and weekly, during the academic year, 1898-present.

La Familia Drug Cartel: Implications For U.S.-Mexican Security, George W. Grayson Dr.

Books, Monographs & Collaborative Studies

La Familia Michoacana burst onto the national stage on September 6, 2006, when ruffians crashed into the seedy Sol y Sombra nightclub in Uruapan, Michoacán, and fired shots into the air. They screamed at the revelers to lie down, ripped open a plastic bag, and lobbed five human heads onto the beer-stained black and white dance floor. The day before these macabre pyrotechnics, the killers seized their prey from a mechanic’s shop and hacked off their heads with bowie knives while the men writhed in pain. “You don’t do something like that unless you want to send a big message,” …

Russia's Prospects In Asia, Stephen J. Blank Dr.

Books, Monographs & Collaborative Studies

These three chapters originated in an SSI conference in January 2010 and go to the heart of a question of vital significance for both Asia and Russia, namely what are Russia’s prospects in Asia. The three chapters outline the challenges Russia faces in Asia, the nature of the dynamic and complex Asian security environment, and the extent to which Russia is or is not meeting those challenges. These chapters represent both Russian and U.S. views and clearly do not agree in their conclusions or analyses. For this reason, they are all the more interesting. These chapters should provoke debate, reflection, …

Enacting An Assets Pedagogy To Develop Youth Assets: Teaching K-12 Urban Youth In An After-School Visual Arts Program Using Participatory Action Research, Maureen Mccarthy

Art Education Theses

Abstract

After my first years of teaching art within a school that perpetuated a deficit paradigm, I was one of two graduate students who taught with two professors in an alternative site at a community center with urban youth from ages 7-17 years. We enacted an assets model that sought to strengthen learners' artistic thinking. Using qualitative participatory action research, I began a study of the teaching practices of Ruth, one of the art educators, to find what happens when an assets model that strengthens learner's artistic thinking is infused into the goals of an after-school visual arts program. I …

Social Support And Family Criticism: Potential Moderators Of The Relationship Between Functional Impairment, Illness Burden, And Depression., Joshua Paul Hatfield

Electronic Theses and Dissertations

Social support and family criticism variables were examined as potential moderators of the association between illness burden and depression and between functional impairment and depression in a secondary data analysis. Participants (n=735) were older adults aged 65 and older from internal medicine and family medicine primary care offices. It was hypothesized that both illness burden and functional impairment would be associated with increased depressive symptoms and a diagnosis of depression. In addition, it was hypothesized that higher levels of social support and lower levels of family criticism would moderate this relationship. Both linear and logistic multivariate hierarchical regression analyses were …

The Post-Nuclear Family And The Depoliticization Of Unplanned Pregnancy In Knocked Up, Juno, And Waitress, Kristen Hoerl, Casey Ryan Kelly

Department of Communication Studies: Faculty Publications

This essay explores three films from 2007, Knocked Up, Juno, and Waitress, which foreground young women’s unplanned pregnancies. These movies depoliticize women’s reproduction and motherhood through narratives that rearticulate the meaning of choice. Bypassing the subject of abortion, the women’s decisions revolve around their choice of heterosexual partners and investment in romantic relationships. Although they question the viability of the nuclear family for single pregnant women, these films represent new iterations of post-feminism that ultimately restore conservative ideas that valorize pregnancy and motherhood as women’s imperatives. We conclude by addressing how these movies present a distorted and …

Targeted Insertion Of Cysteine By Decoding Uga Codons With Mammalian Selenocysteine Machinery, Xue-Ming Xu, Anton A. Turanov, Bradley A. Carlson, Min-Hyuk Yoo, Robert A. Everley, Renu Nandakumar, Irina Sorokina, Steven P. Gygi, Vadim N. Gladyshev, Dolph L. Hatfield

Department of Biochemistry: Faculty Publications

Cysteine (Cys) is inserted into proteins in response to UGC and UGU codons. Herein, we show that supplementation of mammalian cells with thiophosphate led to targeted insertion of Cys at the UGA codon of thioredoxin reductase 1 (TR1). This Cys was synthesized by selenocysteine (Sec) synthase on tRNA^[Ser]Sec and its insertion was dependent on the Sec insertion sequence element in the 3′ UTR of TR1 mRNA. The substrate for this reaction, thiophosphate, was synthesized by selenophosphate synthetase 2 from ATP and sulfide and reacted with phosphoseryl-tRNA^[Ser]Sec to generate Cys-tRNA^[Ser]Sec. Cys was inserted in vivo at UGA …

Concurrent Sexual And Substance-Use Risk Behaviours Among Female Sex Workers In Kenya's Coast Province: Findings From A Behavioural Monitoring Survey, Simon Pierre Tegang, S. Abdallah, G. Emukule, Stanley Luchters, Nzioka Kingola, M. Barasa, Stephen Mucheke, P. Mwarogo

Population Health, East Africa

While many studies confirm the association between HIV, alcohol and injecting drug use by female sex workers (FSWs), little is known about their use of marijuana, khat and other substances and the association of these substances with HIV, risky sexual behaviour, and sexual violence. To better understand this association, data were analysed from a cross-sectional, behavioural survey of 297 FSWs in Mombasa, a well-known tourist destination and the second largest port in Africa and capital city of the Coast Province in Kenya. Among the FSWs, lifetime use of different substances was reported by 91% for alcohol, 71% for khat, 34% …

Feeling Happier When Paying More: Dysfunctional Counterfactual Thinking In Consumer Affect, Sukki Yoon, Patrick Vargas

Marketing Department Faculty Journal Articles

In this research the authors examine whether counterfactual thinking, the process of imagining alternatives to reality, can have a detrimental impact on consumers’ feelings. Five studies examine the dysfunctional role of counterfactual thinking in the presence of Minimum Purchase Requirement conditional message framing (“X% off all purchases if you spend at least $Y”), and its affective consequences. Results show that the presence or absence of the minimum amount restriction (Studies 1A and 1B), success or failure to meet the restriction (Studies 2A and 2B), and perceived closeness (i.e., outcome proximity) to success or failure in meeting the restriction (Study 3), …

Goodbye Avandia!, Aus A. Alzaid

Saudi Medical Journal

No abstract provided.

Neamine Inhibits Cell Proliferation, Migration, And Invasion In H7402 Human Hepatoma Cells, Jia Zhao, Yi-Cun Wang, Lin-Yan Yang, De-Hai Yu, Peng-Tao Pan, Li Wang

Saudi Medical Journal

OBJECTIVE: To explore the effect of neamine on cell proliferation, migration, and invasion in H7402 human hepatoma cells. METHODS: This study was conducted at the Institute of Genetics and Cytology, School of Life Science, Northeast Normal University, Changchun, China between October 2008 and February 2010. First, we employed the MTT (thiazol blue tetrazolium bromide) and soft agar assay to detect the effect of neamine on cell proliferation, and investigated the migration and invasion by using a transwell assay in H7402 cells. We, then, investigated nuclear translocation of angiogenin by immunofluorescence staining. Finally, we stable transfected H7402 cells with the plasmids …

Efficacy And Safety Of Tramadol/Acetaminophen In The Treatment Of Breakthrough Pain In Cancer Patients, Ming-Lin Ho, Chih-Yuan Chung, Chuan-Cheng Wang, Hsuan-Yu Lin, Nicholas C. Hsu, Cheng-Shyong Chang

Saudi Medical Journal

OBJECTIVE: We evaluated the analgesic efficacy and safety of tramadol 37.5 mg/acetaminophen 325 mg combination tablet, for the treatment of breakthrough pain in cancer patients. METHODS: This study was conducted at Changhua Christian Hospital, Changhua, Taiwan from January 2006 to February 2007. The single-center and open-label study enrolled 59 opioid-treated cancer patients with at least moderate breakthrough pain (visual analog scale [VAS] score >/=40mm on a 100-mm scale). The efficacy measures included VAS scores and adverse effect assessment 10, 30, and 60 minutes after the administration of tramadol/acetaminophen. Visual analog scale score at time of pain relief was reported. RESULTS: …

Photoselective Vaporization Combined With Bipolar Transurethral Resection For The Treatment Of Large Prostate Adenoma In High-Risk Patients, Yong Zhao, Ji Chen, Muwen Wang, Peng Sun, Lianjun Li, Haiyang Zhang, Xunbo Jin

Saudi Medical Journal

OBJECTIVE: To evaluate the safety and effectiveness of the combined photoselective vaporization of the prostate (PVP) and bipolar transurethral resection of the prostate (TURP) in high-risk symptomatic patients with large prostates. METHODS: Between January 2007 and January 2010, a prospective study was performed in Shandong Provincial Hospital, Shandong University, Jinan, Shandong Province, China. One hundred and one patients presenting with various kinds of systematic diseases, and with an American Society of Anesthesiologists score of 3 or greater underwent PVP plus bipolar TURP for severe lower urinary tract symptoms due to benign prostatic hyperplasia with prostatic volume greater than 80 ml. …

Use Of Fibrin Glue In The Management Of Recurrent Pterygium By Conjunctival Autograft, Virendra K. Malik, Sandeep Kumar

Saudi Medical Journal

OBJECTIVE: To evaluate whether use of fibrin glue instead of sutures for the treatment of recurrent pterygium with conjunctival auto-graft (CAG) further decreases its recurrence. METHODS: A prospective, clinical open trial of 50 eyes of 50 patients with recurrent pterygium, who were randomly assigned to either, pterygium excision and CAG with fibrin glue (Group 1) or with 6 interrupted sutures (Group 2), was carried out from January 2009 to July 2010 at the outpatient department of Subharti Medical College, Meerut, North India. Both groups had 25 patients each. The groups were compared with regards to the surgical time taken, development …

The Relationship Among Human Papilloma Virus Infection, Survivin, And P53 Gene In Lung Squamous Carcinoma Tissue, Yue-Hua Wang, De-Jie Chen, Tie-Nan Yi, Xiao-Hong Liu

Saudi Medical Journal

OBJECTIVE: To study the relationship between the infection of human papillomavirus (HPV) type 16, type 18, the expression of survivin, and the mutation of p53 gene in lung squamous carcinoma tissue for the research of pathogenesis of lung carcinoma. METHODS: This study was carried out at the Laboratory of Molecular Biology, Xiangfan Central Hospital of Hubei Province, China from September 2008 to May 2010. Forty-five specimens of lung squamous carcinoma tissue confirmed by histopathology were the excisional specimens taken by the Thoracic Surgery of Xiangfan Central Hospital. Normal tissue, closely adjacent to the fresh carcinoma specimens, was used as the …

Screening For Influenza Viruses In 7804 Patients With Influenza-Like Symptoms, Xuehui Li, Nan Lv, Chen Hangwei, Lanhua You, Huimin Wang

Saudi Medical Journal

OBJECTIVE: To screen a large number of patients with influenza-like symptoms by using the gold-immunochromatographic assay kit. METHODS: All patients with influenza-like symptoms visiting the outpatient department of the General Hospital of Beijing Military Region, Beijing, China between May 2009 and January 2010 were enrolled in the study. Nasopharyngeal swabs were collected immediately after the patient visited, then a gold-immunochromatographic assay was performed for screening of influenza A and B viruses according to the kit protocol. RESULTS: Among the 7804 patients enrolled in this study, 202 patients were influenza virus-positive; the positive cases accounted for 2.6% of all cases detected. …