Digital Commons Network^™

A Monomeric Variant Of Insulin Degrading Enzyme (Ide) Loses Its Regulatory Properties, Eun Suk Song, David W. Rodgers, Louis B. Hersh

Molecular and Cellular Biochemistry Faculty Publications

BACKGROUND: Insulin degrading enzyme (IDE) is a key enzyme in the metabolism of both insulin and amyloid beta peptides. IDE is unique in that it is subject to allosteric activation which is hypothesized to occur through an oligomeric structure.

METHODOLOGY/PRINCIPAL FINDINGS: IDE is known to exist as an equilibrium mixture of monomers, dimers, and higher oligomers, with the dimer being the predominant form. Based on the crystal structure of IDE we deleted the putative dimer interface in the C-terminal region, which resulted in a monomeric variant. Monomeric IDE retained enzymatic activity, however instead of the allosteric behavior seen with wild …

The Ile Project: A Scalable Option For Customized Information Literacy Instruction And Assessment, Steve Borrelli, Corey M. Johnson, Lara A. Cummings

Communications in Information Literacy

With the vast amount of information available today, information literacy (IL) education is a critical component of undergraduate education necessary to prepare students for tomorrow's world. Instructors want students to demonstrate critical thinking skills and are often disappointed with student submissions resulting from undeveloped IL skills. Library Instruction programs are often tasked with addressing this educational need and often struggle to find a scalable method to provide IL instruction to the student body. The Information Literacy Education (ILE) Project is an asynchronous learning environment tailored to deliver instruction and assessment. Posited as a customizable option to present IL instruction, this …

A Twenty Year Path: Learning About Assessment; Learning From Assessment, Debra L. Gilchrist

Communications in Information Literacy

This article reviews the development of educational assessment from the 1970's to the present, including discussions of basic working definitions and models of assessment in information literacy. It reflects on what librarians have learned from assessment and about assessment, and how this information is being used to improve current and future assessment offerings.

Trends In Salmonella Enteric Serovar Typhi In Nairobi, Kenya From 2004 To 2006, Doris M. Mengo1, Sam Kariuki, Ann W. T. Muigai, Gunturu Revathi

Pathology, East Africa

Background: Typhoid fever is a global health problem. The World Health Organization (WHO) estimates that the current annual global burden of typhoid is approximately 22 million new cases, 5% of which are fatal.

Methodology: To assess the trends in antibiotic resistance in 100 Salmonella enterica serovar Typhi strains were isolated from the blood of patients in Nairobi, Kenya, from 2004 to 2006. All isolates were tested against ampicilin, chloramphenic, nalidixic acid, ciprofloxacin, cotrimoxazole, cefuroxime, cefriaxone, amoxycillin/clavulanic acid, tetracycline and gentamycin. Susceptibility and resistance were determined using MIC and disk diffusion tests.

Results: From 2004 to 2006 a total of 100 …

May Term Travel Courses Offer Faculty A Vivid Classroom, Rachel Hatch

News and Events (Discontinued Series)

No abstract provided.

Report: The Illinois State University Faculty-Staff Newsletter, March 16, 2010, Illinois State University

Illinois State University Report (1966-2012)

Illinois State University bi-weekly employee newsletter.

Communiqué, March 15, 2010, Lindenwood University

Communiqué

The Communiqué was the faculty/staff newsletter for Lindenwood University/College from 1982 to 2016.

Animal Health Matters, Russ Daly, David H. Zeman

Animal Health MATTERS Newsletter

[Page] 1- Iraqi Veterinarian Brings Veterinary-and Life-Experiences to ADRDL [Page] 2- Director's Message — Tomorrow’s Veterinarians and the NAVMEC [Page] 2- Veterinarians with Current USDA Accreditation: Note Program Changes [Page] 4- The Virology Section at SDSU’s ADRDL [Page] 5- Fish Health and Diagnostics Update Pieces and Parts [Page] 6- VSD Faculty Members Honored at SDSU Faculty Recognition Event [Page] 6- ADRDL Assists AIB in Bovine Tuberculosis Diagnostics [Page] 6- 2010 Bailey Herd Health Conference a Success [Page] 6- Faculty Members Attend “Animal Welfare in Veterinary Education and Research” Symposium [Page] 7- Calf Scours Submission Reminders [Page] 7- Calendar of Events

This Week At Stony Brook Southampton/In The News | This Week At Sbs, V.5, N.08, Darren Johnson

Southampton Announcements and News

No abstract provided.

Vesicular Calcium Regulates Coat Retention, Fusogenicity, And Size Of Pre-Golgi Intermediates, Marvin Bentley, Deborah C. Nycz, Ashwini Joglekar, Ismene Fertschai, Roland Malli, Wolfgang F. Graier, Jesse C. Hay

Biological Sciences Faculty Publications

The significance and extent of Ca(2+) regulation of the biosynthetic secretory pathway have been difficult to establish, and our knowledge of regulatory relationships integrating Ca(2+) with vesicle coats and function is rudimentary. Here, we investigated potential roles and mechanisms of luminal Ca(2+) in the early secretory pathway. Specific depletion of luminal Ca(2+) in living normal rat kidney cells using cyclopiazonic acid (CPA) resulted in the extreme expansion of vesicular tubular cluster (VTC) elements. Consistent with this, a suppressive role for vesicle-associated Ca(2+) in COPII vesicle homotypic fusion was demonstrated in vitro using Ca(2+) chelators. The EF-hand-containing protein apoptosis-linked gene 2 …

Central Florida Future, Vol. 42 No. 16, March 15, 2010

Central Florida Future

Knights head to Tallahassee; A wave of rock, for a cause; Librarian from UCF wins award, $2,000 prize; Ride the green waves; Students forced to find solutions to parking problem.

Electrospray Ionization Mass Spectrometry For The Characterization Of Covalent And Noncovalent Polynuclear Platinum Compounds Interacting With Bio-Molecules, John Mangrum

Theses and Dissertations

Polynuclear platinum compounds represent a new class of potential platinum anticancer therapeutics. Derived from the most widely used platinum anticancer drug, cisplatin, these novel compounds are distinct in their interactions with bio-molecules. The effectiveness of platinum anticancer agents is influenced by three pharmacological factors: (i) their resistance to deactivating sulfur nucleophiles, (ii) the ability to gain cellular entry and efficient cellular uptake, and (iii) the ability to form stable and specific complexes with DNA. BBR 3464, the first multinuclear platinum compound to reach phase II clinical trials, has created a new approach to cancer drug design. Large, highly charged platinum …

Physics Alumni Newsletter Spring 2010, Terry Goforth

Physics Alumni Newsletter

Physics Alumni Newsletter

The Physics Alumni Newsletter is produced by the SWOSU Physics Department.

Our Engineering Physics students are recruited in fields such as electronics, aerospace, mechanical engineering, petroleum engineering and software engineering. Graduates also have careers in meteorology, architecture, education and more.

Faculty Senate Resolution 10-03, Louisiana State University And Agricultural & Mechanical College

LSU Faculty Senate Publications

Faculty Senate Resolution on replacing the current system of appointments with a new system of elections for members of the Graduate Council, adopted on March 15, 2010.

Potential For Misidentification Of Environmentally Persistent Free Radicals As Molecular Pollutants In Particulate Matter, Hieu Truong, Slawo Lomnicki, Barry Dellinger

Faculty Publications

Environmentally persistent free radicals (EPFRs) have been shown to form on the surfaces of various types of transition metal-containing particulate matter (PM), and it has been demonstrated they are capable of initiating adverse health impacts. Following sonification and solvent extraction for chemical analysis, they are partially converted to molecular species. Alcoholic solvents extracted the EPFRs with near 100% efficiency, while nonpolar hydrocarbon solvents exhibited < 20% efficiency and dichloromethane exhibited 20-55% efficiency. The extracted radicals reacted in solution to form multiple molecular reaction products including catechol, hydroquinone, phenol, chlorinated phenols, dibenzo-p-dioxin, and dibenzofuran. This suggests that EPFRs in environmental samples are indistinguishable from molecular pollutants and are subject to misidentification as molecular adsorbates when traditional extraction and chemical analysis methods are employed. On the basis of these findings, the origin of the toxicity of particulate matter contaminated with toxic organic compounds should be considered for re-evaluation to include the possibility that EPFRs may be a significant contributor, and the impact of some molecular pollutants may have been overestimated. © 2010 American Chemical Society.

The Daily Gamecock, Monday, March 15, 2010, University Of South Carolina, Office Of Student Media

March

No abstract provided.

Why Terrorism? Whose Terror?, Ibpp Editor

International Bulletin of Political Psychology

The author considers terrorism as a competitor for the legally constituted authority and power of governments.

New Mexico Environmental Flows Workshop Report And Synthesis, From The Environmental Flows Workshop At The University Of New Mexico School Of Law March 15, 2010, Utton Transboundary Resources Center, Unm, Adrian Oglesby

Publications

This report is a synthesis of the presentations and discussions featured at the Utton Transboundary Re-sources Center’s March 15, 2010 Environmental Flows Workshop at the University of New Mexico School of Law. Over 100 stakeholders, lawyers, scientists, and decision-makers gathered to develop a better understanding of how environmental flows are successfully implemented across the West and in New Mexico. They also began the process of evaluating the condition of New Mexico’s rivers and identifying opportunities to conserve and enhance their natural functions.

The goal of the Workshop was to inform a wide range of policy-makers, agency managers and stakeholders of …

The Eastern Echo, March 15, 2010, Eastern Michigan University

EMU Student Newspaper: The Normal News & The Eastern Echo

No abstract provided.

Spartan Daily March 15, 2010, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily (School of Journalism and Mass Communications)

Volume 134, Issue 24

Opening And Closing The Moral Judgment--Moral Action Gap, Carol Frogley Ellertson

Theses and Dissertations

This study analyzed moral psychology's “moral judgment-moral action gap” research and found that morality was being described as a secondary phenomenon produced by underlying substrates (such as identity and self constructs, “brain modules,” and “evolved emotional systems”) which are themselves non-moral. Deriving morality from “the non-moral” presents a kind of ontological gap in the moral psychology research. Researchers implicitly close this gap assuming it is possible to get moral judgments and actions out of non-moral substrates. But the difficulty remains how the moral as “moral” becomes infused into any moral psychology models. Morality is not a secondary phenomenon arising out …

Are Impact Factors Comparable? Impact Factor Comparisons Across Areas Of Psychology, Jason J. Van Der Horst

Theses and Dissertations

Journal impact factors play an increasing role in academics as a tool for evaluating faculty, research, and resource allocations. These evaluations may be effective in departments where the subject matter is reasonably unified. However, given the diversity found within the subject matter of psychology, the impact factors of journals may not be comparable across the various areas. This study compares the average impact factors across decile levels of journals from seven areas of psychology. It is found that impact factor scores are not comparable across the seven areas of psychology. This difference is more pronounced when looking at higher decile …

The Murray Ledger And Times, March 13, 2010, The Murray Ledger And Times

The Murray Ledger & Times

No abstract provided.

The 13c Suess Effect In Scleractinian Corals Mirror Changes In The Anthropogenic Co2 Inventory Of The Surface Oceans, Peter Koenraad Swart, Lisa Greer, Brad E. Rosenheim, Chris S. Moses, Amanda J. Waite, A. Winter, Richard E. Dodge, Kevin P. Helmle

Marine & Environmental Sciences Faculty Articles

New δ¹³C data are presented from 10 coral skeletons collected from Florida and elsewhere in the Caribbean (Dominica, Dominican Republic, Puerto Rico, and Belize). These corals range from 96 to 200 years in age and were collected between 1976 and 2002. The change in the δ¹³C of the skeletons from these corals between 1900 and 1990 has been compared with 27 other published coral records from the Atlantic, Pacific, and Indian Oceans. The new data presented here make possible, for the first time, a global comparison of rates of change in the δ¹³C value …

Flyer News, Vol. 57, No. 33 (March 12, 2010), University Of Dayton

Flyer News

Student-run newspaper of the University of Dayton.

March 31, Uab To Host Symposium On Bone Biology And Osteoporosis, Staff

Browse All News

No abstract provided.

Diversity And Abundance Of The Dark Kangaroo Mouse, Microdipodops Megacephalus, In Communities Of Nocturnal Granivorous Rodents In Western North America, Ashley Sagers Haug

Theses and Dissertations

The dark kangaroo mouse, Microdipodops megacephalus, is a sensitive species in the Great Basin Desert. This thesis explores the structure of desert rodent communities of the Great Basin to better understand M. megacephalus' place in the community and the conditions that promote large and stable populations. To determine community structure, I used nestedness analysis to evaluate 99 communities of nocturnal granivorous rodents. I found that the community structure was non-random, indicating the existence of assembly rules and ecological constraints. I also found that M. megacephalus was the second most vulnerable species in the community. To explore the correlation …

Role Of Members Of The Phosducin Gene Family In Protein Translation And Folding, Nana Sono-Koree

Theses and Dissertations

G proteins regulate various physiological processes by way of transducing a wide variety of signals ranging from hormonal to sensory stimuli. Malfunctions in G protein signaling lead to numerous diseases. G protein signaling begins with binding of a ligand to a G protein-coupled receptor resulting in a conformational change that leads to the exchange of a GDP for a GTP on G α. The GTP bound α subunit dissociates for its stable Gβγ dimer partner. G α-GTP and Gβγ control the activity of effector enzymes and ion channels that ultimately orchestrate the cellular response to stimulus. Current reports have shown …

Automatic Identification And Tracking Of Retraction Fibers In Time-Lapse Microscopy, Meher Talat Shaikh

Theses and Dissertations

Digital image processing is widely used in the field of time-lapse microscopy and biological research to provide statistical data of cellular dynamics. The data can provide more comprehensive understanding of the molecular phenomenon. Further, digital image processing enables rapid and consistent quantification of qualitative observations. The image processing model examined here provides a study to identify structures called retraction fibers (RFs) that are formed during epithelial-mesenchymal transition (EMT) [1], an important developmental process which also occurs during cancer metastasis. Quantifying RF formation is an important task for biologists studying cellular regulation of EMT. This thesis work uses digital image processing …

Campus Report, Vol. 37, No. 7, University Of Dayton

Campus Report

Elie Wiesel speaks on combating indifference, intolerance, injustice; Mike Kelly and Tim Wabler talk sports and so much more; Celebration of the Arts line-up announced; and deans Thomas Lasley and Lisa Kloppenberg talk about what's next as they step down.