Digital Commons Network^™

Network Pharmacology And Bioinformatics Analysis Of The Potential Mechanism Of Sesame Oil In Treating Insomnia, La Mu, Ze Wengyongzhong, Sang Jikangzhuo, Hua Erjiang, Jiang Yongsilang

Food and Machinery

[Objective] To explore the molecular mechanism of sesame oil in treating insomnia by network pharmacology, bioinformatics, and molecular docking methods. [Methods] Sesame oil targets are screened by TCMSP and Herb databases, while insomnia-related targets are searched in GeneCard, ETCM, DrugBank database, and GSE 189993 data set. Then, the intersection is found to obtain the common targets. The protein interaction network is constructed by the String software for gene ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. The binding abilities of the active ingredients and the targets are evaluated by molecular docking on the AutoDock …

Effect Of Sugar Concentrations On Flavor Substances In Xiangxi Radish Pickles Based On Gc-Ms And 16s Rrna, Liu Shimei, Zhou Yingjun, Zheng Zhihao, Xie Chunliang, Su Xiaojun

Food and Machinery

[Objective] To explore the effect of sugar concentration on the flavor formation of Xiangxi radish pickles, in response to the "sugar reduction" demand for healthy diets. [Methods] Three sugar treatment groups are set up at the concentrations of 10%, 30%, and 50%. Then, the dynamic changes of metabolites and microbial community structure are systematically monitored during the fermentation process using gas chromatography-mass spectrometry (GC-MS) combined with 16S rRNA high-throughput sequencing. [Results] Levilactobacillus and Lactiplantibacillus are the dominant genera, with the highest abundance observed in the 10% sugar concentration group (P<0.05). In the later fermentation stage, the 30% sugar concentration group accumulates more alcohols, sugars, and organic acids, resulting in a more harmonious flavor profile. According to the partial least squares discriminant analysis (PLS-DA), 16 key metabolites are identified. Additionally, correlation analysis reveals that the two dominant genera are significantly associated with the metabolism of 9 and 12 flavor substances, respectively. [Conclusion] Moderate reduction of sugar concentration contributes to microbial community function and flavor substance synthesis.

Proteomics Of Tribute Citrus Turbid Juice And Characteristic Analysis Of Cloudy Proteins, Wang Feng, Liu Zhen, Ma Lukai, Wang Qin, Xiao Gengsheng, Liu Dongjie

Food and Machinery

[Objective] This study aims to investigate the characteristics of protein components and the types of cloudy proteins in Tribute citrus turbid juice. [Methods] Proteomics was used to analyze the proteomic features of the supernatant proteins and precipitated proteins in Tribute citrus turbid juice. [Results] There were significant differences in the electrophoresis bands of the supernatant proteins and precipitated proteins in Tribute citrus turbid juice. Compared with the supernatant proteins, precipitated proteins contained 2 897 differential proteins, including 2 487 up-regulated differential proteins and 410 down-regulated differential proteins. The up-regulated differential proteins in Tribute citrus turbid juice were mainly enriched in …

Mechanisms Of Licochalcone A In Inhibiting Tumor Growth Via Lncrna-Cdc 42bpa-Ampk/Mtor Axis, Shi Zhan, Yao Meicun, Shi Xianyong, Tan Panpan

Food and Machinery

[Objective] To investigate the molecular mechanism by which licochalcone A inhibits colorectal cancer growth through regulation of the AMPK/mTOR signaling axis via long non-coding RNAs (LncRNAs). [Methods] Human colorectal cancer HCT 116 cells and a nude mouse subcutaneous xenograft model were used. Cell proliferation was assessed by CCK-8 and EdU assays, and cell migration was evaluated by wound healing and Transwell assays. Quantitative PCR (qPCR) was employed to detect the expression levels of proliferation- and migration-related markers, and Western blotting was performed to analyze the expression of proteins related to the AMPK/mTOR pathway. Differential expressed LncRNAs in HCT 116 cells …

Extraction And Analysis Of Structural Characterization And Antioxidant Activity Of Polysaccharides From Xiaobai Apricots, Chen Lin, Abudureheman Buhailiqiemu, Jiang Luxi, Tang Rui, Zhang Jianlin, Gao Zhihui

Food and Machinery

[Objective] To explore the extraction process and structural characterization of polysaccharides from Xiaobai apricots. [Methods] Xinjiang Xiaobai apricots are used as raw materials. The extraction process of Xiaobai apricot polysaccharides is optimized using response surface methodology (RSM). The structural properties of the polysaccharides are characterized by high-performance liquid chromatography (HPLC), Fourier transform infrared spectroscopy (FT-IR), differential refractometry, and scanning electron microscopy (SEM). The antioxidant activity is evaluated by measuring the scavenging abilities of DPPH radicals, ABTS+ radicals, and hydroxyl radicals. [Results] The optimal extraction conditions are determined as a solid-to-liquid ratio of 1∶40 (g/mL), extraction time of 6 h, and …

Comparison Of Amino Acids And Volatile Flavor Compounds In Various Parts Of Ternary Pig Meat, Li Rui, Wang Jingyu, Shi Xixiong, Zhang Aiwen, Yu Xuan, Xu Linna

Food and Machinery

[Objective] To scientifically evaluate the differences of amino acids and volatile flavor compounds in various parts of Ternary pig meat. [Methods] The composition of amino acids and volatile flavor compounds in front leg meat, hind leg meat, and longissimus dorsi muscle of the Ternary pig is compared and analyzed. [Results] The total amino acid content of fore limb meat, hind limb meat, and longissimus dorsi muscle is 16.13, 15.69, and 17.26 g/100 g, respectively. The essential amino acid content is 6.33, 6.12, and 6.71 g/100 g, respectively. The non-essential amino acid content is 9.79, 9.57, and 10.56 g/100 g, respectively. …

Extraction Process Optimization And Antioxidant Activity Of Total Flavonoids From Pomelo Peel By Natural Deep Eutectic Solvents Combined With Microwaves, Xie Wen, Zhang Shuo, Wang Fang, Huang Xinyi

Food and Machinery

[Objective] To optimize the extraction process of total flavonoids from pomelo peel by natural deep eutectic solvents (NADES) combined with microwaves. [Methods] The extraction ability of flavonoids from pomelo peel is analyzed among three NADES and conventional extractants combined with microwaves. Additionally, the extraction process is optimized by response surface experiment, and the antioxidant activity of the extracts is evaluated. [Results] The optimal total flavonoid extraction rate is 2.20 percent at a liquid-solid ratio of 23∶1 (mL/g), a water content of 29%, an extraction temperature of 73 ℃, and a microwave time of 40 seconds. Under these conditions, the DPPH …

Research Progress In Regulating The Egg White Emulsification Properties By Structured Modification, Yang Fanghan, Ai Minmin, Wang Ziyuan, Guo Shanguang, Xiao Nan

Food and Machinery

Egg white, valued for its high protein content and superior food functional properties, is widely utilized in food processing. The amphiphilic structure and surface activity of egg white proteins enable effective adsorption at oil-water interfaces, reducing interfacial tension and forming stable interfacial films. Therefore, egg white proteins exhibit a robust interfacial regulation capacity in emulsion systems. This review systematically outlines the characteristics and formation mechanisms of multi-scale emulsion systems of egg white proteins (nano-emulsions, Pickering emulsions, and high internal phase Pickering emulsions). Additionally, a summary is presented of the research progress on the chemical/physical modification mechanisms of egg white emulsification …

Research And Application Progress Of Functional Raw Materials For Blood Glucose-Lowering Foods, Wang Zhenwu, Chen Xiaoqing, Ding Ning, Chen Yaling, Chen Xumeng, Xia Xinbin

Food and Machinery

Type 2 diabetes mellitus involves a variety of pathological mechanisms. Chinese medicine treatment often employs the Chinese medicinal materials such as Coptidis Rhizoma and Astragali Radix with both medicinal and edible values to achieve multi-target synergistic blood glucose-lowering effects. Using these materials as the main ingredients to develop functional foods such as meal replacements, snacks, and drinks for lowering blood glucose becomes an innovative strategy for managing type 2 diabetes mellitus. This paper systematically reviews five blood glucose-lowering mechanisms of functional foods and drug ingredients, including protection of islet β-cells, enhancement of insulin sensitivity, inhibition of α-amylase, regulation of lipid …

Research Progress On Functional Characteristics Of Bioactive Substances And Preservation And Processing Technologies Of Clausena Lansium, Liao Lisui, Gang Jie, Jiang Aili, Zhao Tong

Food and Machinery

Clausena lansium is a fruit with both medicinal and edible value, widely distributed in southern China. It is rich in polysaccharides, amino acids, flavonoids, phenols, alkaloids, and terpenoids, which exhibit various pharmacological effects such as antioxidant, antitumor, anti-inflammatory, and antibacterial activities. However, C.lansium is highly perishable and difficult to preserve. Therefore, preservation technologies such as ethylene inhibitors, low-temperature storage, film coating, and modified atmosphere packaging are applied to extend its shelf life. This paper reviews the latest research progress on the main bioactive substances, pharmacological effects, postharvest preservation, and food processing and utilization of C.lansium, and provides an outlook on …

Properties And Research Progress Of Deacetylated Konjac Glucomannan In Food Applications, Liu Kai, Zhang Ling, Wang Jing

Food and Machinery

Konjac glucomannan (KGM) is a natural soluble dietary fiber that is safe, biodegradable, and edible, with wide application in food and biomedicine. However, due to low plasticity and stability, KGM usually requires blending, physical, and chemical modification for production. Currently, deacetylated konjac glucan (DKGM) is used in food mainly as a food additive, food preservative, and health food. This review elucidates the KGM property changes before and after different deacetylation degrees, as well as the application progress and research status of DKGM in the food industry, with prospects for its development trends.

Construction Of Sulfur Dioxide Fluorescent Probe And Its Application Progress In Food, Pharmaceuticals, And Biological Systems, Xiao Zhongshan, Yang Guojing, Gao Ha, Wang Tianlin

Food and Machinery

Sulfur dioxide (SO2) and its derivatives (SO2-3 and HSO-3) are ubiquitous in the environment and our daily life, closely related to human life activities. As an important additive, SO2 serves functions including bleaching, sterilization, anti-corrosion, color protection, antioxidant, and others during the processing and storage of food and pharmaceuticals. Additionally, SO2 can regulate the antioxidant enzyme system in human cells, increasing resistance against oxidative stress damage. However, excessive SO2 in the human body can strongly stimulate the digestive tract, causing nausea, vomiting, and abdominal pain, and may trigger allergic reactions including asthma and headaches. Furthermore, long-term intake can damage digestive …

Using Machine Learning Algorithms To Clarify Relationships Between Soil Properties And Lead Stomach Bioaccessibility, Shehan Wijesinghe, Dibyendu Sarkar, Hadeer Saleh, Khalid Mustafa, Smitha Rao, Rupali Datta

Michigan Tech Publications

Featured Application: This paper has important applications in environmental health risk assessment and urban soil remediation planning. By demonstrating how machine learning can predict lead bioaccessibility in lead paint-contaminated soil, the study provides a scalable, cost-effective alternative to laboratory-based extraction methods. Such models could support rapid screening of contaminated sites, helping prioritize high-risk areas for intervention and allocate remediation resources more efficiently. This model is expected to advance data-driven decision-making for managing lead-contaminated soils and protect vulnerable urban populations from exposure. Lead contamination in urban soils, primarily from deteriorating lead-based paint, poses a significant health risk in the United States. …

A Platform For Acquiring And Classifying Low-Noise Electrocardiogram Signals For Applications In Cardiovascular Monitoring, Begmamat Berdimurodovich Dushanov, Narzullo Mamatov Dr.

Technical science and innovation

The early screening and continuous monitoring of cardiovascular diseases need effective acquisition and smart processing of electrocardiogram (ECG) signals. In this article, we introduce a compact platform designed for the acquisition of low-noise ECG signals and classification of the signals using a one-dimensional convolutional neural network (1D-CNN). Our compact platform consists of a low-noise analog front-end (AFE), including an instrumentation amplifier and a chain of analog filters, along with a data acquisition component designed to ensure effective suppression of baseline wander and high frequencies. Our compact platform consumes a low amount of power and can therefore be used for continuous …

A Hybrid Xfem-Ml Framework For High-Fidelity, Rapid Fracture Prediction In Cortical Bone: From Microstructure To Clinical Translation, Noor T. Al-Sharify, Ammar Fadhil Hussein Al-Maliki, Ahmed Ali Farhan Ogaili, Abdul-Rasool Kareem Jweri, Alaa Abdulhady Jaber, Luttfi A. Al-Haddad

Mesopotamian Journal of Computer Science

This paper proposes a hybrid computational model, which combines the eXtended Finite Element Method (XFEM) with machine learning (ML) to forecast the fracture behavior of cortical bone while maintaining microstructural fidelity. It has created a parametric dataset of about 450 three-dimensional XFEM models of single-edge notched bend (SENB) specimens, including important μ-structure features (e.g., osteon orientation, cement line properties, interfacial connectivity, etc.). Based on these simulations, 47 quantitative descriptors were obtained, and these were used to model supervised ML models, namely, Random Forest and Artificial Neural Networks, to estimate fracture load. The Random Forest model demonstrated exceptional predictive performance (R …

Research Progress In Detection Methods Of Lysinoalanine, Xia Yimiao, Chen Qumei, Chen Fusheng, Luo Shuangqun

Food and Machinery

Lysinoalanine (LAL) is a cross-linked amino acid formed through the addition of lysine and dehydroalanine. High-protein foods are prone to forming LAL during food processing (such as alkaline treatment, heat treatment). LAL may induce nephrotoxicity, affect human digestive function, and can also reduce the content of essential amino acids in food, reducing the nutritional value of food. Currently, LAL quantification primarily relies on liquid chromatography (LC) and liquid chromatography-mass spectrometry (LC-MS) methods. This study reviews and discusses the detection methods of LAL from three aspects: pretreatment, derivatization, and instrumental detection, aiming to provide insights for developing high-sensitivity, more accurate, and …

Effect Of Myrcene On Quality Of Sea Cucumbers During Keeping Alive With Water, Mi Hongbo, Feng Mengmeng, Chen Jingxin, Liu Chao, Li Jianrong, Li Xuepeng

Food and Machinery

[Objective] To investigate the optimal concentration of myrcene and prolong the time of keeping sea cucumbers alive with low-temperature and water. [Methods] The effect of of myrcene concentrations (0, 10, 20, 30, 40, 50 µL/L) on the pH, hardness and soluble protein content of sea cucumbers during keeping alive with water is analyzed. The changes in sensory scores, body wall moisture status and distribution, and microstructure of sea cucumbers before and after keeping alive are compared. The effect of myrcene with the optimal concentration on the immune and antioxidant enzyme activities of sea cucumbers during keeping alive [Results] As the …

Claudins Interact With Lilrb Immune Inhibitory Receptors To Promote Myeloid Immunosuppression In Cancer, Xiaoye Liu, Ryan Huang, Zhiqiang Ku, Jingjing Xie, Heyu Chen, Yubo He, Qi Lou, Chengcheng Zhang, Xing Yang, Cheryl Lewis, Jade Homsi, Ankit Gupta, Lei Dong, Kenian Chen, Annabel Tu, Liming Du, Hailong Yu, Qing Hu, Meng Fang, Bufan Li, A E M Adan Khan, Caroline Simith, Samuel John, Lin Xu, Ningyan Zhang, Zhiqiang An, Cheng Cheng Zhang

The Brown Foundation: Institute of Molecular Medicine

The mechanisms underlying tumor cell-myeloid cell interactions in the tumor microenvironment (TME) remain unclear, and predictive biomarkers for patient response to myeloid checkpoint blockade are lacking. This study identified specific binding between tight junction claudins (CLDNs) and leukocyte immunoglobulin-like receptor subfamily B2 (LILRB2) and LILRB5. In multiple human cancer cohorts, the spatial proximity of LILRB2-positive macrophages to CLDN-expressing cancer cells correlated with clinical outcomes, highlighting this spatial relationship as a potential biomarker. In syngeneic LILRB2-transgenic and humanized mouse models, CLDN18.2-LILRB2 interactions triggered bidirectional signaling, enhanced the immunosuppressive activity of myeloid cells, and accelerated tumor progression. These effects were reversed by …

Characterization Of Srsf1’S Functions In Transcription And Alternative Splicing, Elena Bisotto

Electronic Theses and Dissertations

Serine/Arginine splicing factor 1 (SRSF1) is an RNA-binding protein (RBP) that serves as a central regulator of RNA biogenesis. SRSF1 has been implicated in cell replication, motility, ageing, immune function, and other physiological processes, while its dysregulation is associated with multiple cancers and autoimmune diseases. In this study, we characterized the global impact and structural requirements of SRSF1-mediated gene regulation to elucidate its proto-oncogenic functions.

Utilizing a time-course RNA sequencing (RNA-seq) approach in HEK293 cells, we identified 28 primary transcriptional targets of SRSF1, 18 of which were consistently upregulated in the established cancer cell models PC-3 and MCF-7. These targets …

Developmental Dynamics Of Frontal Alpha-Band Eeg Coherence And Fearful Temperament Across Infancy, Samantha Christiana Gott

Electronic Theses and Dissertations

Infancy represents a period of rapid neural development during which early temperamental traits begin to emerge. Fearful reactivity, a core dimension of temperament, has been linked to later risk for anxiety and related internalizing outcomes. The present study examined developmental patterns of frontal alpha-band electroencephalographic (EEG) coherence across infancy and tested whether neural connectivity within frontal regions was associated with fearful temperament. Participants were 61 infants recruited through a multisite longitudinal study conducted at Florida Atlantic University, Washington State University, and Virginia Tech. Infants completed laboratory visits at approximately 6, 8, 10, and 12 months of age. During each visit, …

Population Discontinuity In The Paris Basin Linked To Evidence Of The Neolithic Decline, Frederik V. Seersholm, Abigail Ramsøe, Jialu Cao, Philippe Chambon, Karl Göran Sjögren, Hugh Mccoll, Fabrice Demeter, Charleen Gaunitz, Lasse Vinner, Jesper Stenderup, Gabriele Scorrano, Ralph Fyfe, T. Douglas Price, Morten Fischer Mortensen, Sascha Krüger, Torben Dehn, Svend Illum Hansen, Kristine Vesterdorf, Thorfinn Sand Korneliussen, Morten E. Allentoft, Kristian Kristiansen, Laure Salanova, Eske Willerslev, Martin Sikora

School of Geography, Earth and Environmental Sciences

At the transition between the third and the fourth millennium BC, there is evidence for a population decline concurrent with the end of megalith building across continental northwestern Europe. In Scandinavia this ‘Neolithic decline’ is followed by a massive population turnover, as farming communities disappeared and were replaced by people with steppe ancestry. In western Europe, however, ancestry associated with Neolithic farmers persisted beyond the Neolithic decline, and it remains unclear whether a similar demographic replacement occurred. To investigate the population dynamics around the Neolithic decline in present-day France, we sequenced 132 ancient genomes from the allée sépulcrale at Bury. …

The International And Comparative Aspects Of United States V. Skrmetti: The Detrimental Rise Of Anti-Trans Sentiment In The United States, Julia Parrey

Immigration and Human Rights Law Review

In recent years, anti-trans sentiment has significantly increased in the United States. This Article examines the legal advocacy by the LGBTQ+ community that laid key legal groundwork for basic protections through landmark US Supreme Court decisions like Lawrence v. Texas and Obergefell v. Hodges and analyzes how recent judicial and legislative actions signal a dangerous reversal of that progress.

The central analysis focuses on the consequences of United States v. Skrmetti, where the Supreme Court upheld Tennessee’s ban on gender-affirming care for minors by applying rational-basis review, concluding that the law classified based on age or medical diagnosis, rather …

Adaptive Parallel Downloader For Large Genomic Datasets, Rasman Mubtasim Swargo

Miners Solving for Tomorrow Research Conference

Modern next-generation sequencing (NGS) projects routinely generate terabytes of data that researchers download from public repositories such as SRA and ENA. Existing download tools typically employ static concurrency settings, leading to inefficient bandwidth utilization and prolonged download times under dynamic network conditions. We introduce FastBioDL, a parallel downloader for large biological datasets with an adaptive concurrency controller. FastBioDL frames downloading as an online optimization problem, using a utility function and gradient descent to adjust the number of concurrent socket streams during runtime. This approach maximizes throughput while minimizing resource overhead. Evaluations on public genomic datasets show that FastBioDL achieves up …

Using The Second-Generation Environmental Sample Processor To Provide Near Real-Time Observations Of Harmful Algae And Assess Biodiversity And Ecosystem Change, Stephanie K. Moore, Nicolaus G. Adams, John B. Mickett, Christina M. Mikulski, Nicolas Michel-Hart, James M. Birch, Brent Roman, Jan A. Newton

Benefits of Ocean Observing Catalog (BOOC)

The second-generation Environmental Sample Processor (2G-ESP) is a sophisticated autonomous sensor platform and a key component of offshore observing efforts designed to mitigate the societal impacts of harmful algal blooms (HABs) in the Pacific Northwest. Deployed as part of a moored observatory, the 2G-ESP generates near real-time data on HAB organisms and the biotoxin domoic acid, providing critical HAB early warning and directly informing HAB forecasts and fisheries management decisions. In addition, the platform’s capacity to archive environmental DNA enables retrospective analyses of biodiversity and ecosystem change. These capabilities facilitate interdisciplinary scientific collaboration and information sharing, ultimately enhancing our collective …

Harnessing Wavefront Shaping Control For Sensing Applications, Pablo Jara

Miners Solving for Tomorrow Research Conference

Diffuse optical tomography (DOT) and functional near-infrared spectroscopy (fNIRS) enable deep, non-invasive sensing in biological tissue but are fundamentally limited by the photon budget - most injected light is lost to scattering before reaching the detector. Wavefront shaping (WFS) can enhance signal strength inside scattering media via interference, but the conventional diffusion-based sensitivity model breaks down under coherent illumination. We develop a microscopic theory of optical sensitivity that captures interference effects neglected by diffusion theory. We prove analytically that the microscopic and diffusive descriptions coincide under random illumination and identify WFS strategies that enhance sensitivity beyond this limit. The maximum …

Against The Coloniality Of Sport For Development And Peace (Sdp), Isra Shahid Iqbal

Journal of Global South Sport Studies

This paper critically investigates how historical colonial practices and capitalist structures continue to influence the roles, relationships, and spaces related to gender and race within Sport for Development (SDP) initiatives in Global South contexts. While sport is commonly approached as an avenue to promote positive youth development and post-conflict reconstruction, these discourses often overlook how colonial capitalist imperatives are perpetuated through sport, influencing gender and race hierarchies, oppressive relations, and the direct “Othering” of actors in Global South contexts (Samie et al., 2015; Oxford, 2017). Indeed, SDP initiatives are not immune from capitalist and colonial imperatives nor the racial and …

Leveraging Artificial Intelligence For Transformative Education: Challenges And Recommendations, Papia Bawa

Journal of Research Initiatives

The sheer force with which GPT models are inundating business, education and economic fields speaks to its ability to not only transform the ways in which we interact and act but also disrupt these ways. This systematic literature review applies the PSALSAR method to synthesize findings from 72 articles on AI applications in education, emphasizing its transformative potential across various domains. AI is transforming personalized learning by customizing content and feedback to individual needs, addressing challenges like data privacy and ethical concerns. It enhances administrative efficiency through automation and data-driven decision-making, improving institutional performance while managing biases and maintaining human …

County Of El Paso Et Al. V. Michael Chertoff, Secretary, Us Dhs, Case 308-Cv-00196-Fm

Border Wall / Border Security Documents

Filings relating to U.S. District Court for the Western District of Texas, El Paso Division, Case 308-cv-00196-FM

Six-Week Time-Restricted Eating Lowers Premature Mortality Risk In Overweight Early Elderly Adults: Evidence From A Body Shape Index, Przemysław Domaszewski, Mariusz Konieczny

Baltic Journal of Health and Physical Activity

Background: A Body Shape Index (ABSI) is an anthropometric indicator combining waist circumference, weight, and height, providing a BMI-independent measure of central obesity and a recognized predictor of mortality. Despite its relevance, research on ABSI in early elderly populations remains limited. This study assessed the impact of a six-week time-restricted eating (TRE) intervention on ABSI z-scores in overweight adults aged 65–74, with attention to gender differences. Materials and Methods: A total of 116 participants were randomized into a TRE group (16:8 fasting window from 8:00 PM to 12:00 PM) or a control group maintaining habitual eating. ABSI z-scores were evaluated …

Documents Compiled By The No Border Wall Coalition, No Border Wall Coaltion

Border Wall / Border Security Documents

No abstract provided.