Digital Commons Network^™

Constitutive Modeling Of Glassy Memory Polymers, Mahesh Khanolkar

Dissertations

The aim of this research is to develop constitutive models for non-linear materials. Here, issues related for developing constitutive model for glassy shape memory polymers are addressed in detail. Shape memory polymers are novel material that can be easily formed into complex shapes, retaining memory of their original shape even after undergoing large deformations. The temporary shape is stable and return to the original shape is triggered by a suitable mechanism such heating the polymer above a transition temperature. Glassy shape memory polymers are called glassy because the temporary shape is fixed by the formation of a glassy solid, while …

Modeling With Bivariate Geometric Distributions, Jing Li

Dissertations

This dissertation studied systems with several components which were subject to different types of failures. Systems with two components having frequency counts in the domain of positive integers, and the survival time of each component following geometric or mixture geometric distribution can be classified into this category. Examples of such systems include twin engines of an airplane and the paired organs in a human body. It was found that such a system, using conditional arguments, can be characterized as multivariate geometric distributions. It was proved that these characterizations of the geometric models can be achieved using conditional probabilities, conditional failure …

Experiences Of Pregnancy, Childbirth And Post-Partem Period In Urban And Suburban Immigrant Pakistani Women, Rubab I. Qureshi

Dissertations

A body of research suggests that immigrants arrive in the U.S. in good health, a healthy immigrant effect. As immigrants acculturate and absorb dominant cultural norms (measured by proxy variables such as language preference, employment, smoking and alcohol consumption), their health status deteriorates. There is a need to understand how immigrants adapt to a changed social and cultural environment and how this may influence health.

A study of pregnancy, childbirth and the postpartum period in immigrant Pakistani women living in New Jersey explored the interface of culture, immigration and health. The study employed a three pronged approach. Census data were …

Design Of Drug Delivery Strategies Based On Well-Stirred Experiments, Kumud Kanneganti

Theses

Drugs are generally administered to the human body via injections (IV) or through other paths such as the buccal, nasal routes. The main consideration when designing a medication schedule is to maintain a therapeutic level of the drug in the body during the course of treatment. To achieve this goal, when IV drug therapy is selected, particular importance has to given to the dose to be injected and how to maintain the concentration of the pharmaceutical active ingredient (API) in the body between a Minimum Toxic Concentration (MTC) and a Minimum Effective Concentration (MEC). This therapeutic range varies with the …

Minimum Agitation Speed For Solid Suspension And Mixing Time In A Torispherical -Bottomed Pharmaceutical Stirred Tank Under Different Baffling Conditions, Dilanji Bhagya Wijayasekara

Theses

The minimum agitation speed, NS, required to just suspend solid particles dispersed in water was experimentally determined in this work for a glass-lined type of mixing tank provided with a torispherical bottom and agitated with a retreat-blade impeller under different baffling configurations. Ns for the same tank but equipped with a different agitation system, namely an axial impeller, was also experimentally determined for the purpose of comparing of performances of the two systems. The effect of impeller off- bottom clearance and the vessel's liquid level on the minimum agitation speed were also experimentally studied. Njs, was experimentally determined …

Axon Guided Axon Growth In Drg Neurons From The Spinal Cord Of Rat Embryos, Neha Jain

Theses

Early studies in the area of neuronal physiology and injury have shown that axons are guided by a number of physical as well as chemical cues. Although the guidance effect of initial axons and their processes on later axons has been shown from a development point of view, little light has been thrown on the subject from the injury point of view. This important ability of axons which plays a key role during development and formation of neuronal networks could become crucial in repairing damaged nerves and disrupted neuronal tracts.

In the following study, the guidance effect of an older …

Geometric Effects On The Wear Of Microfabricated Silicon Journal Bearings, Shpend Demiri

Theses

This dissertation presents an investigation of geometric effects on the wear of large aspect ratio silicon journal microbearings. The consideration of geometric conformality of rotor and hub as a critical design parameter manifests from the inherent properties of deep reactive ion etching as part of the current MEMS fabrication process employed in this dissertation. The investigation is conducted in two phases, each characterized by novel microbearing designs, fabrication processes, experimental test methodologies, and characterization techniques. The intent of Phase 1 is to focus on the effects of conformality of wear, while the intent of Phase 2 is to focus on …

"Something Begins Its Presencing": Negotiating Third-Space Identities And Healing In Toni Morrison's Paradise And Love, Kristen King

USF Tampa Graduate Theses and Dissertations

Toni Morrison’s Paradise deconstructs the pathology of patriarchy and its oppressive nature, which limits language and knowledge. Patriarchal language silences female voice as they unknowingly adopt male definitions of gender and femininity. As long as the women are denied access to a language that allows them to define themselves, their existence is marked by a perennial state of self-destruction and stasis. As the women, specifically Consolata, begin to reject patriarchal limitations, they gain agency and with it an access to words and ideas that allow them to identify and articulate their own definition of self.

Morrison’s Love illustrates the individual’s …

Chk2 Is Negatively Regulated By Protein Phosphatase 2a, Alyson Freeman

USF Tampa Graduate Theses and Dissertations

Checkpoint kinase 2 (CHK2) is an effector kinase of the DNA damage response pathway and although its mechanism of activation has been well studied, the attenuation of its activity following DNA damage has not been explored. Here, we identify the B'α subunit of protein phosphatase 2A (PP2A), a major protein serine/threonine phosphatase of the cell, as a CHK2 binding partner and show that their interaction is modulated by DNA damage. B'α binds to the SQ/TQ cluster domain of CHK2, which is a target of ATM phosphorylation. CHK2 is able to bind to many B' subunits as well as the PP2A …

"Speaking" Subalterns: A Comparative Study Of African American And Dalit/Indian Literatures, Mantra Roy

USF Tampa Graduate Theses and Dissertations

“Speaking Subalterns” examines the literatures of two marginalized groups,African Americans in the United States and Dalits in India. The project demonstrates how two disparate societies, USA and India, are constituted by comparable hegemonic socioeconomic-cultural and political structures of oppression that define and delimit the identities of the subalterns in the respective societies. The superstructures of race in USA and caste in India inform, deform, and complicate the identities of the marginalized along lines of gender, class, and family structure. Effectively, a type of domestic colonialism, exercised by the respective national elitists, silence and exploit the subaltern women and emasculate the …

Effects Of Monoclonal Anti-Abeta Antibodies On The Amyloid Beta Peptide Fibrillogenesis And Their Involvement In The Clearance Of Alzheimer's Disease Plaques, Jeffy Pilar Jimenez

USF Tampa Graduate Theses and Dissertations

Alzheimer’s disease (AD) is the most common cause of senile dementia worldwide. AD is a neurodegenerative disorder characterized by the loss of memory and language skill, collapse of the cognitive function, and distortion of social behavior. As of today, the onset mechanisms of AD and cure are unknown; however, three hallmarks are commonly encountered: extra and intracellular accumulation of amyloid beta (A!) peptide plaques, formation of intracellular neurofibrillary tangles, and inevitable neuronal death. Hypothetically, a possible scenario provoking or involved in the onset of AD is a cascade effect that starts with an imbalance in the production and clearance of …

Chemical Investigation Of The Antarctic Marine Invertebrates Synoicum Adareanum And Artemisina Plumosa, Jaime Heimbegner Noguez

USF Tampa Graduate Theses and Dissertations

Of the small percentage of organisms chemically investigated over the years as potential sources of natural products, much less is known about those from the marine realm. Despite the lack of attention they have received in comparison to terrestrial organisms, marine life have recently been found to represent a valuable source for novel bioactive compounds. Cold water marine habitats are home to a plethora of organisms that have the ability to produce secondary metabolites that exhibit a great deal of diversity in both their chemical structures and biological activities. The chemical investigation of these unique and relatively unstudied ecosystems is …

Ecotourism And Water Quality: Linking Management, Activities And Sustainability Indicators In The Caribbean, Ken Darrie Thomas

USF Tampa Graduate Theses and Dissertations

Ecotourism from its genesis and founding theories has been set out to conserve and preserve the environment through sustainable operation that includes surrounding communities in efforts to reduce their poverty levels. Over the years ecotourism has been hypothesized to have departed from this ideal with several researchers, through social, qualitative analyses, have said that these non-sustainable ecotourism operations are simply due to poor management. This work sought to test this central hypothesis as a first approach to quantitatively linking ecotourism activities to management with surface water quality as the key indicator of sustainable ecotourism as a complex system through systems …

Comparison Between Different Techniques Of Preprocessing For Resting State Fmri Analysis, Megha Girdhar

Theses

Resting state functional connectivity as the name suggests is defined as significant temporal correlation between spatially distinct regions of the brain during rest. In this thesis, fMRI resting state dataset was analyzed using different available processing techniques with the same fMRI data to study differences between the various methods. All the imaging data from each of the subjects was processed in an identical fashion. The same method was used for detecting connectivity. The number of independent components in the data was used as the base to differentiate the effect of each of these methods. Independent component analysis was performed on …

A Dual Function Of V0-Atpase A1 Provides An Endolysosomal Degradation Mechanism In Drosphila Melanogaster Photoreceptors, W. Ryan Williamson, Dong Wang, Adam Haberman, R. Robin Heisinger

Biology: Faculty Scholarship

The vesicular adenosine triphosphatase (v-ATPase) is a proton pump that acidifies intracellular compartments. In addition, mutations in components of the membrane-bound v-ATPase V0 sector cause acidification-independent defects in yeast, worm, fly, zebrafish, and mouse. In this study, we present a dual function for the neuron-specific V0 subunit a1 orthologue v100 in Drosophila melanogaster. A v100 mutant that selectively disrupts proton translocation rescues a previously characterized synaptic vesicle fusion defect and vesicle fusion with early endosomes. Correspondingly, V100 selectively interacts with syntaxins on the respective target membranes, and neither synaptic vesicles nor early endosomes require v100 for their acidification. In …

04. Commencement Of The Class Of 2010, Illinois Mathematics And Science Academy

Class of 2010

No abstract provided.

A Nonlinear Ode Model Of Tumor Growth And Effect Of Immunotherapy And Chemotherapy Treatment In Colorectal Cancer, Hannah P. Savage

HMC Senior Theses

Colorectal cancer will kill approximately 50,000 people in the United States this year. Current treatment options, including surgery, chemotherapy, and radiation, are often able to force the cancer into remission, but better treatments are needed to help those who don't respond to current treatments. A new and promising treatment option, monoclonal-antibody therapy, has the potential to help reduce the deaths caused by colorectal cancer, but most monoclonal-antibody drugs are currently still in trial phases, and the variations in the dosing schedule of those currently approved for use have not been heavily explored. We have modified a nonlinear ODE tumor/treatment model …

Minimal Circuits For Very Incompletely Specified Boolean Functions, Richard Strong Bowen

HMC Senior Theses

In this report, asymptotic upper and lower bounds are given for the minimum number of gates required to compute a function which is only partially specified and for which we allow a certain amount of error. The upper and lower bounds match. Hence, the behavior of these minimum circuit sizes is completely (asymptotically) determined.

Assessment Of Epidermal Growth Factor Receptor (Egfr) Expression In Human Meningioma., A Gabriella Wernicke, Adam P Dicker, Michal Whiton, Jana Ivanidze, Terry Hyslop, Elizabeth H Hammond, Arie Perry, David W Andrews, Lawrence Kenyon

Kimmel Cancer Center Faculty Papers

PURPOSE: This study explores whether meningioma expresses epidermal growth factor receptor (EGFR) and determines if there is a correlation between the WHO grade of this tumor and the degree of EGFR expression.

METHODS: Following institutional review board approval, 113 meningioma specimens from 89 patients were chosen. Of these, 85 were used for final analysis. After a blinded review, immunohistochemical stains for EGFR were performed. Staining intensity (SI) was scored on a scale 0-3 (from no staining to strong staining). Staining percentage of immunoreactive cells (SP) was scored 1-5 (from the least to the maximum percent of the specimen staining). Immunohistochemical …

2010 Rose-Hulman Institute Of Technology : One-Hundred And Thirty-Second Commencement, Rose-Hulman

Commencement Programs

No abstract provided.

The Design Integration Of An Animal Shelter Into Martin Luther King Middle School, Anna Givens

Theses and Dissertations

This thesis explores the design integration of an animal shelter into an existing school in an at-risk neighborhood. The connection between at-risk students and homeless animals is valuable to the design. A large central courtyard located within Martin Luther King Middle School serves as a connection between both students and animals. Because the animal shelter is located in a central location within the school, students and animals have a greater ability to form a connection necessary for the program to work. This thesis is about the interaction between both animals and students through the process of design.

2010 Commencement Program, Whittier College

Commencement Programs

Whittier College's One Hundred Seventh Annual Commencement, May 28, 2010

Commencement Address: Mr. O'Brien

Supplement file includes the One Hundred Seventh Annual Whittier College Baccalaureate, May 27, 2010

Upper Ocean Response To The Atmospheric Cold Pools Associated With The Madden-Julian Oscillation, Suyang Pei, Toshiaki Shinoda, Alexander Soloviev, Ren-Chieh Lien

Marine & Environmental Sciences Faculty Articles

Atmospheric cold pools are frequently observed during the Madden‐Julian Oscillation events and play an important role in the development and organization of large‐scale convection. They are generally associated with heavy precipitation and strong winds, inducing large air‐sea fluxes and significant sea surface temperature (SST) fluctuations. This study provides a first detailed investigation of the upper ocean response to the strong cold pools associated with the Madden‐Julian Oscillation, based on the analysis of in situ data collected during the Dynamics of the Madden‐Julian Oscillation (DYNAMO) field campaign and one‐dimensional ocean model simulations validated by the data. During strong cold pools, SST …

Induction Of Neuro-Protective/Regenerative Genes In Stem Cells Infiltrating Post-Ischemic Brain Tissue, Gokhan Yilmaz, J Steven Alexander, Cigdem Erkuran Yilmaz, D Neil Granger

Publications and Research

Background- Although the therapeutic potential of bone marrow-derived stromal stem cells (BMSC) has been demonstrated in different experimental models of ischemic stroke, it remains unclear how stem cells (SC) induce neuroprotection following stroke. In this study, we describe a novel method for isolating BMSC that infiltrate postischemic brain tissue and use this method to identify the genes that are persistently activated or depressed in BMSC that infiltrate brain tissue following ischemic stroke. Methods- Ischemic strokes were induced in C57BL/6 mice by middle cerebral artery occlusion for 1 h, followed by reperfusion. BMSC were isolated from H-2 Kb-tsA58 (immortomouse™) mice, and …

Volume Cxxvii, Number 25, May 28, 2010, Lawrence University

The Lawrentian

No abstract provided.

Forest Park: A Call To Action, City Club Of Portland (Portland, Or.)

City Club of Portland

No abstract provided.

Evidence For A Role Of Endocannabinoids, Astrocytes And P38 Phosphorylation In The Resolution Of Postoperative Pain, Matthew S. Alkaitis, Carlos Solorzano, Russell P. Landry, Daniele Piomelli, Joyce A. Deleo, E. Alfonso Romero-Sandoval

Dartmouth Scholarship

Background: An alarming portion of patients develop persistent or chronic pain following surgical procedures, but the mechanisms underlying the transition from acute to chronic pain states are not fully understood. In general, endocannabinoids (ECBs) inhibit nociceptive processing by stimulating cannabinoid receptors type 1 (CB₁) and type 2 (CB₂). We have previously shown that intrathecal administration of a CB₂ receptor agonist reverses both surgical incision-induced behavioral hypersensitivity and associated over-expression of spinal glial markers. We therefore hypothesized that endocannabinoid signaling promotes the resolution of acute postoperative pain by modulating pro-inflammatory signaling in spinal cord glial cells. …

A Novel Gene Network Inference Algorithm Using Predictive Minimum Description Length Approach, Vijender Chaitankar, Preetam Ghosh, Edward J. Perkins, Ping Gong, Youping Deng, Chaoyang Zhang

Faculty Publications

Background: Reverse engineering of gene regulatory networks using information theory models has received much attention due to its simplicity, low computational cost, and capability of inferring large networks. One of the major problems with information theory models is to determine the threshold which defines the regulatory relationships between genes. The minimum description length (MDL) principle has been implemented to overcome this problem. The description length of the MDL principle is the sum of model length and data encoding length. A user-specified fine tuning parameter is used as control mechanism between model and data encoding, but it is difficult to …

Electrochemistry Calendar, Editorial Office Of J.Electrochem.

Journal of Electrochemistry

No abstract provided.

Electrochemical Behavior Of Kaempferide Interaction With Protein, Li-Qing Lin, Xin-Hua Lin, Jing-Hua Chen, Li-Ying Huang, Yin-Huan Liu, Guang-Wen Li

Journal of Electrochemistry

The electrochemical behavior of kaempferide at activated GCE and the interaction of kaempferide with human serum albumin(HSA) were investigated by cyclic voltammetry. A differential pulse voltammetric method has been proposed for the determination of the HSA with kaempferide. In pH 4. 5 phosphate buffer solutions (PBS) kaempferide can react with HSA to form an electrochemically non-active supermolecular complex at activated GCE,resulting in the decrease of oxidation peak (at 0. 468 V) without the change of peak potential. The decrease of the peak current is proportional to HSA concentration in the range of 0. 05 ～ 0. 25 mg/L. The limit …