Digital Commons Network^™

Reducing The Effects Of Intracellular Accumulation Of Thermolabile Collagen Ii Mutants By Increasing Their Thermostability In Cell Culture Conditions., Katarzyna Gawron, Deborah A. Jensen, Andrzej Steplewski, Andrzej Fertala

Department of Dermatology and Cutaneous Biology Faculty Papers

Mutations in collagen II are associated with spondyloepiphyseal dysplasia, a group of heritable diseases whose common features include aberrations of skeletal growth. The mechanisms through which mutations in collagen II affect the cartilaginous tissues are complex and include both intracellular and extracellular processes. One of those mechanisms involves cellular stress caused by excessive accumulation of misfolded collagen II mutants. We investigated whether stabilizing the structure of thermolabile R789C and R992C collagen II mutants would improve their secretion from cells, thereby reducing cellular stress and apoptosis. Employing glycerol and trimethylamine N-oxide (TMAO), chemicals that increase the thermostability of collagen triple helices, …

Western News, May 27, 2010, Western Michigan University

Western News (1972-2018)

Story highlights: Campus getting ready for visit by Obama; WMU names new business, honors college deans; WMU slates info sessions for MPSERS employees; On Campus with Enedelia Cruz.

'Game-Changing' Nanomaterial

News Releases

No abstract provided.

The Observer, Central Washington University

Student Newspaper

Student newspaper for Central Washington University for May 27-June 2, 2010. Vol 85, No. 8.

2010-05-27 Unm News Minute, University Of New Mexico Communication And Marketing Department

UNM News Minute 2010

No abstract provided.

Mississippi Canyon 252 Incident Nrda Tier 1 For Deepwater Communities, Gregory Boland, Gary Brewer, Erik Cordes, Amanda Demopoulos, Chuek Fisher, Chris German, Ken Sulak

United States Geological Survey: Staff Publications

The northern Gulf of Mexico (GOM) is geologically diverse basin, described as the most complex continental slope region in the world. Regional topography of the slope consists of basins, knolls, ridges, and mounds derived from the dynamic adjustments of salt and the introduction of large volumes of sediment over long time scales. More than 99% of the sea floor in the GOM consists of soft sediment made up of various mixtures of primarily silt and clay. These wide-spread soft bottom communities are described in reports from major MMS studies by Gallaway et al. (1998) and Rowe and Kennicutt (2009). Relative …

Mustang Daily, May 27, 2010

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

Investigation Of Science Education Attitudes In Alternative High School Settings, Sarah Jane Rogers

Theses and Dissertations

This study compared the attitudes of administrators, teachers and students in school settings for at-risk students. Students are considered at-risk if they are not academically successful. Teacher and student science education attitudes were analyzed by survey data and categorization of teaching practices. Additionally, data from classroom videotapes and teacher interviews was collected to support and triangulate survey data. Study participants were selected from two school settings for at-risk students 1) public alternative schools (PAS) and 2) private residential treatment centers (RTC). When the survey questions were analyzed by school type and teacher classification several differences were found between 1) teacher …

Central Florida Future, Vol. 42 No. 33, May 27, 2010

Central Florida Future

Waldrop named new provost; Uncover Thursdays; Art Grad; Plus: Wholesome summertime fun; No place for video games at the movies; First SGA meeting reveals vacancies; Professors, students react to oil spill in Gulf;

An Empirical Approach To Evaluating Sufficient Similarity: Utilization Of Euclidean Distance As A Similarity Measure, Scott Marshall

Theses and Dissertations

Individuals are exposed to chemical mixtures while carrying out everyday tasks, with unknown risk associated with exposure. Given the number of resulting mixtures it is not economically feasible to identify or characterize all possible mixtures. When complete dose-response data are not available on a (candidate) mixture of concern, EPA guidelines define a similar mixture based on chemical composition, component proportions and expert biological judgment (EPA, 1986, 2000). Current work in this literature is by Feder et al. (2009), evaluating sufficient similarity in exposure to disinfection by-products of water purification using multivariate statistical techniques and traditional hypothesis testing. The work of …

Role Of Capsule In The Interaction Of Porphyromonas Gingivalis With Host, Amrita Singh

Theses and Dissertations

Periodontal disease is a chronic oral disease that is triggered by bacteria. One of these bacteria is Porphyromonas gingivalis. Some strains of P. gingivalis produce capsule, however, so far the role of capsule in the interactions with host cells in P. gingivalis is not well understood. Here, we investigated the contribution of capsule to triggering host response as well as its protective role on bacterial internalization by host cells with subsequent killing. qRT-PCR analysis showed more upregulation of expression of various groups of genes in macrophages challenged with the non-capsulated strain than in those challenged with the capsulated one with …

State Versus Ethnic Identification In Tibati, Cameroon, Brian Hillery

Capstone Projects – Politics and Government

The purpose of this paper is to analyze state versus ethnic identification among residents of Tibati, Cameroon, and to question whether identification suggests the existence of tribalism. This study explores how residents of Tibati who more strongly identify with their ethnic group than the state are more likely to express dissatisfaction with the Cameroonian government, using information collected through informal conversations about the level of satisfaction of Tibatians with regards to both their ethnic group and the Cameroonian government.

This paper provides a synopsis of the major ethnic groups in Tibati and a brief historical summary of Cameroonian state evolution …

The Economic And Environmental Effects Of An Eu Ban On Illegal Logging Imports. Insights From A Cge Assessment, Francesco Bosello, Ramiro Parrado, Renato Rosa

Fondazione Eni Enrico Mattei Working Papers

Illegal logging is widely recognized as a major economic problem and one of the causes of environmental degradation. Increasing awareness of its negative effects has fostered a wide range of proposals to combat it by major international conservation groups and political organizations. Following the 2008 US legislation which prohibits the import of illegally harvested wood and wood products, the European Union (EU) is now discussing a legislation proposal which would ban illegal timber from the EU market. In this study we use the ICES computable general equilibrium model to estimate the reallocation of global demand and timber imports following the …

Synthesis Of Polyethylene/Starch Hybrids Using Aqueous Mini Emulsion Polymerization, Brinda Shah

Theses

Sustainability regarding the most produced plastic, polyethylene, was the main motivation factor behind research of this thesis. The aim was to synthesize hybrids of polyethylene and starch in an aqueous mini emulsion polymerization process using single-site catalysts. Two types of water soluble starches were applied: potato and hydroxyethyl starch. A trifluoromethane bearing nickel enolate catalyst and a 5-halo 3-methoxy salicyl aldiminate nickel pyridyl catalyst (with Cl and Br as halogen atoms) were used as polymerization catalysts, the latter two known to results in higher molecular weight polymer. The first catalyst turned to be sufficiently active with increased loads of starch …

05/26/2010 Obituary Records, Hawaii Obituaries

Obituaries

List of Obituaries for individuals who passed away on 05/26/2010. Scroll down to see the names and obituary description.

Inhibition Of Proliferation And Induction Of Apoptosis In Multiple Myeloma Cell Lines By Cd137 Ligand Signaling, Charles A. Gullo Phd, Liang Kai Koh, Wan Lu Pang, Kian Tong Ho, Shi Hao Tan, Herbert Schwarz

Biochemistry and Microbiology

Background

Multiple myeloma (MM) is a malignancy of terminally-differentiated plasma cells, and the second most prevalent blood cancer. At present there is no cure for MM, and the average prognosis is only three to five years. Current treatments such as chemotherapy are able to prolong a patient's life but rarely prevent relapse of the disease. Even hematopoietic stem cell transplants and novel drug combinations are often not curative, underscoring the need for a continued search for novel therapeutics. CD137 and its ligand are members of the Tumor Necrosis Factor (TNF) receptor and TNF superfamilies, respectively. Since CD137 ligand cross-linking enhances …

Spectator 2010-05-26, Editors Of The Spectator

The Spectator

No abstract provided.

Volume 47, Number 40: May 26, 2010, University Of North Dakota

University Letter Archive

No abstract provided.

The Guardian, May 26, 2010, Wright State University Student Body

The Guardian Student Newspaper

Twelve page issue of The Guardian, the official student-run newspaper for Wright State University. The Guardian has been published regularly since March of 1965.

Functionalization Of Fibers Using Azlactone-Containing Polymers: Layer-By-Layer Fabrication Of Reactive Thin Films On The Surfaces Of Hair And Cellulose-Based Materials, Maren E. Buck, David M. Lynn

Chemistry: Faculty Publications

We report an approach to the functionalization of fibers and fiber-based materials that is based on the deposition of reactive azlactone-functionalized polymers and the "reactive" layer-by-layer assembly of azlactone-containing thin films. We demonstrate (i) that the azlactone-functionalized polymer poly(2-vinyl-4,4-dimethylazlactone) (PVDMA) can be used to modify the surfaces of a model protein-based fiber (horsehair) and cellulose-based materials (e.g., cotton and paper), and (ii) that fibers functionalized in this manner can be used to support the fabrication of covalently cross-linked and reactive polymer multilayers assembled using PVDMA and poly(ethyleneimine) (PEI). The growth, chemical reactivity, and uniformity of films deposited on these substrates …

Changing Patterns Of Microhabitat Utilization By The Threespot Damselfish, Stegastes Planifrons, On Caribbean Reefs, William F. Precht, Richard B. Aronson, Ryan M. Moody, Les M. Kaufman

Ocean Engineering and Marine Sciences Faculty Publications

The threespot damselfish, Stegastes planifrons (Cuvier), is important in mediating interactions among corals, algae, and herbivores on Caribbean coral reefs. The preferred microhabitat of S. planifrons is thickets of the branching staghorn coral Acropora cervicornis. Within the past few decades, mass mortality of A. cervicornis from white-band disease and other factors has rendered this coral a minor ecological component throughout most of its range. Methodology/Principal Findings:Survey data from Jamaica (heavily fished), Florida and the Bahamas (moderately fished), the Cayman Islands (lightly to moderately fished), and Belize (lightly fished) indicate that distributional patterns of S. planifrons are positively correlated with live …

A Comparison Of Probe-Level And Probeset Models For Small-Sample Gene Expression Data, John R. Stevens, Jason L. Bell, Kenneth I. Aston, Kenneth L. White

Mathematics and Statistics Faculty Publications

Background: Statistical methods to tentatively identify differentially expressed genes in microarray studies typically assume larger sample sizes than are practical or even possible in some settings.

Results: The performance of several probe-level and probeset models was assessed graphically and numerically using three spike-in datasets. Based on the Affymetrix GeneChip, a novel nested factorial model was developed and found to perform competitively on small-sample spike-in experiments.

Conclusions: Statistical methods with test statistics related to the estimated log fold change tend to be more consistent in their performance on small-sample gene expression data. For such small-sample experiments, the nested factorial model can …

Robin Lite 3d Fmcw Bird Radar: Revolutionizing Airport Birdstrike Prevention, Addy Borst

Bird Strike Committee-USA/Canada Joint Annual Meeting: 11th (2009)

Table of Contents:
The avian radar arena
A new kid in town: ROBIN Lite 3D FMCW avian radar
Our roots in radar technology
Our roots in avian radars
From raw radar data to realtime info bird movements
ROBIN Lite 3D FMCW: System design requirements driven by users
Main avian radar system requirements
System design conclusions ROBIN Lite 3D FMCW
ROBIN Lite 3D FMCW implementation
ROBIN Lite 3D FMCW: Horizontal radar
ROBIN Lite 3D FMCW: Vertical radar
ROBIN Lite 3D FMCW: Data acquisition electronics
ROBIN Lite 3D FMCW Signal/image processing
ROBIN Lite 3D FMCW ground clutter filter
ROBIN Lite 3D FMCW …

Mustang Daily, May 25, 2010

Cal Poly Student Newspaper

Student newspaper of California Polytechnic State University, San Luis Obispo, CA.

Alternative Paths Toward A Low Carbon World, Valentina Bosetti, Carlo Carraro, Massimo Tavoni

Fondazione Eni Enrico Mattei Working Papers

This paper analyzes the economic and investment implications of a series of climate mitigation scenarios, characterized by different levels of ambition in terms of long term stabilization goals and the transition to attain them. In particular, the implications of fairly ambitious scenarios are investigated for the first time by means of the model WITCH. Although milder climate objectives can be achieved at moderate costs, our results show that stringent stabilization paths, compatible with the target of the European Union and the G8, might have important economic repercussions. The timing of mitigation action influences the cost of meeting a target as …

Methods Of Isolating Specific Compounds From Supramammary Lymph Node Tissue, Steven E. Ellis, Thomas R. Scott

Clemson Patents

Methods of forming proteinaceous products such as cell culture supplement capable of supporting the growth and culturing of cells, tissue, and organs, are generally disclosed. One method generally provides for the collection of the internal tissue of an animal, such as a bovine, and the processing of the internal tissue to degrade and/or lyse the tissue components. A cell culture supplement or other proteinaceous product can be prepared from the processed tissue. A proteinaceous product can include, for example, a complete protein profile of the tissue or only certain biological factors extracted from the tissue. Collected internal tissue can be …

Documenting Lineages From My ‘Littlest Ancestor’ To My Deep Ancestral Roots, Emily F. Schmitt Lavin

Biology Faculty Proceedings, Presentations, Speeches, Lectures

No abstract provided.

Memorandum Of Understanding, Regarding Quality Of Education - Student Discipline By And Between Plaintiffs And Defendants, May 25, 2010, United States. District Court (Florida : Middle District)

Concerned Organization for Quality Education for Black Students, Inc.

A memorandum of understanding between Leon Bradley as the plaintiff acting for the Concerned Organization for the Quality Education of Black Students, Inc. (COQEBS), and the Pinellas County School Board about student discipline and the quality of education for Black students in Pinellas County, Florida.

Application Of Structured Light Imaging For High Resolution Mapping Of Underwater Archaeological Sites, Chris Roman, Gabrielle Inglis, James Rutter

Graduate School of Oceanography Faculty Publications

This paper presents results from recent work using structured light laser profile imaging to create high resolution bathymetric maps of underwater archaeological sites. Documenting the texture and structure of submerged sites is a difficult task and many applicable acoustic and photographic mapping techniques have recently emerged. This effort was completed to evaluate laser profile imaging in comparison to stereo imaging and high frequency multibeam mapping. A ROV mounted camera and inclined 532 nm sheet laser were used to create profiles of the bottom that were then merged into maps using platform navigation data. These initial results show very promising resolution …

Organic Cation Transporter Preferentially Expressed In Hematopoietic Cells And Leukemias And Uses Thereof, Jeffrey A. Moscow, Xin Lu, Craig Jordan

Markey Cancer Center Faculty Patents

A novel organic cation transporter (OCT) gene, OCT 6, and use thereof is described. The OCT6 gene is preferentially expressed in human hematopoietic tissues, including CD34+ cells and leukemia cells. Its narrow tissue distribution, substrate specificity, and close homology to other cell membrane transporters make OCT6 an attractive target for the treatment of myeloid diseases.