Digital Commons Network^™

Ecological Drift And Host Filtering Jointly Structure Foliar Endophytes During Ecosystem Development., Caio César Pires De Paula, Petr Macek, Milan Varsadiya, Jakub Borovec, Mehmet A. Balkan, Brett S. Younginger, Daniel J. Ballhorn, Tomáš Picek, Tomáš Hájek, Jan Frouz, Jiří Bárta, Dagmara Sirová

Biology Faculty Publications and Presentations

Foliar endophytes contribute to plant nutrient acquisition, stress tolerance, and pathogen resistance, yet their responses to ecosystem-level processes remain poorly understood. Using a space-for-time substitution design, we investigated bacterial and fungal community dynamics in the foliar endosphere of four phylogenetically distinct plant hosts across a well-characterized successional chronosequence.

Developing An Effective Integrated Marketing Communication Game Plan For Today’S Consumers: Examining Marketing Methods That Work And How To Make The Proper Strategy Adjustments To Remain Relevant In The Future, Michele M. Wisnesck

Electronic Theses and Dissertations

As a seasoned marketing professional, I’ve seen marketing trends and gimmicks come and go, but more critically, I’ve seen consumers shift their behavior in significant ways. The guiding research question for this project asks: With the constantly evolving marketing and consumer landscape and regular use of AI agents like ChatGPT or Google Gemini, how can marketing and communication professionals remain relevant? In short, the answer to this question is that integrated marketing communication (IMC) practitioners must adapt to ongoing consumer behavior changes brought on by technology advancements while leveraging a combination of traditional persuasive techniques, a variety of modern marketing …

Postoperative Stress Accelerates Atherosclerosis Through Inflammatory Remodeling Of The Hdl Proteome And Impaired Reverse Cholesterol Transport, Dominique M. Boucher, Victoria Lorant, Valerie Rochon, Abigail Carter, Cameron Stotts, My Anh Nguyen, Thomas Laval, Christina Emerton, Nathan Joyce, Nysa Vinayak, Marlena Scaffidi, David Cook, Katey J. Rayner, Rebecca C. Auer, Scott M. Gordon, Mireille I. Ouimet

Physiology Faculty Publications

Over 10 million patients undergoing non-cardiac surgery each year face major cardiovascular complications within 30 days, many due to destabilized atherosclerotic plaques. Reverse cholesterol transport (RCT), driven by HDL and Apoa1, protects against plaque progression, but the effects of surgical inflammation on this pathway remain unclear. Using an abdominal laparotomy model in ApoE^−/− mice on a Western diet, we isolated the impact of surgical inflammation without confounding blood loss. Surgery acutely impaired RCT and cholesterol efflux, with inflammatory remodeling of HDL marked by elevated SAA1/2 and reduced Apoa1. Plaques exhibited higher intracellular lipids, PLIN2 expression, and cleaved caspase-3, indicating …

Academic Self-Efficacy, Intelligence Mindset, And Locus Of Control In Predicting Academic Engagement Among English-Speaking First-Generation First-Year College Students In The United States, Carlene Camacho-Valentine

Walden Dissertations and Doctoral Studies

No abstract provided.

Comparative Effectiveness Of Low Versus High Dose Upadacitinib As Maintenance Treatment In Patients With Ulcerative Colitis: A Real-World Cohort Study From The United States, Priya Sehgal, Gursimran S. Kochhar, Harpreet Kaur, Himsikhar Khataniar, Raina Shivashankar, James D. Lewis, Aakash Desai

Division of Gastroenterology and Hepatology Faculty Papers

BACKGROUND: There is limited real-word data comparing efficacy of low dose upadacitinib (UPA) to high dose UPA as maintenance therapy for ulcerative colitis (UC).

METHODS: This was a retrospective cohort study utilizing the U.S. Collaborative Network in adults ≥18 years old with UC who initiated UPA 15 mg compared to 30 mg for maintenance therapy between April 2022 and December 2023. The primary outcome was a composite of intravenous steroid use, oral steroid use, or colectomy from 12 to 60 weeks from the index UPA prescription. Propensity score matching (PSM) was performed for demographics, co-morbid conditions, laboratory, and IBD medication …

Mending The Research-Practice Gap In Psychology: Using Role-Play, Self-Reflection, And Ai Feedback To Enhance Unified Protocol Skill Development, Farryn A. Pauly

Honors Theses

This study explores ways to bridge the research-practice gap in psychology by examining how role-play, structured self-reflections, and AI-generated feedback support the development of Unified Protocol (UP) clinical skills. Using a single-subject design, the researcher simulated therapy sessions with a volunteer acting as the patient, implementing UP modules in sequence, while collecting both quantitative and qualitative data. Each session included preparation using the UP, role-play, and pre- and post-session reflection. Performance was evaluated using Lyssn, an AI-based platform that generated Cognitive Therapy Rating Scale (CTRS; Young & Beck, 1980) scores and detailed feedback on CBT techniques. This was interpreted and …

Expanding Expanded Access: A Case Of Onc201 And The Ethical Limitations Of Compassionate Use, Ava C. Hutchings

Honors Theses

This study examines the ethical and structural limitations of the Expanded Access program in the United States, with particular focus on its application to terminal pediatric illness. Although the program is intended to provide patients with life-threatening conditions access to investigational therapies outside of clinical trials, its effectiveness in serving critically ill children remains uncertain. This program is analyzed through careful consideration of regulatory review and ethical theory. Key policies governing Expanded Access are examined alongside scholarly discussions of pediatric autonomy and parental authority.

A case study of ONC201, a now-approved investigational drug, is used to illustrate how Expanded Access …

Practicing In Broken Systems: An Advanced Integrated Social Work Portfolio, Andrew Tomt

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This portfolio documents my development as an advanced integrated social worker within behavioral health and crisis response systems. Grounded in the ten CSWE competencies, it illustrates my progression from foundational generalist practice to a more complex, systems-oriented approach that integrates ethical decision-making, trauma-informed care, research-informed practice, and policy awareness. Drawing on my practicum experience in Mobile Crisis Assessment and Triage (MCAT) in Spokane, Washington, the portfolio demonstrates my ability to engage, assess, intervene, and evaluate across micro, mezzo, and macro levels. It highlights my commitment to social justice, cultural humility, and least-restrictive care, while also addressing the challenges of working …

Msw Portfolio, Jasmine J. Klingaman

Graduate Student Portfolios, Professional Papers, and Capstone Projects

This Master of Social Work (MSW) portfolio presents a comprehensive demonstration of professional growth and mastery of the ten core competencies as aligned with the standards of the National Association of Social Workers (NASW) and the Department of Social Work. Through selected artifacts and critical reflection, the portfolio illustrates the integration of knowledge, values, skills, and cognitive and affective processes essential for advanced integrated practice. Emphasis is placed on ethical and professional behavior, engagement with diversity and difference, and the application of research-informed and evidence-based practice. The portfolio further highlights competence in policy practice, engagement, assessment, intervention, and evaluation across …

Maternal Opioid Use And Hepatitis C Infection Disrupt The Placental Immune Landscape And Structure, Heather E. True, Brianna M. Doratt, Sheridan B. Wagner, Delphine C. Malherbe, Nathan R. Shelman, Mahdi Eskandarian Boroujeni, Cynthia Cockerham, John M. O'Brien, Ilhem Messaoudi

Markey Cancer Center Faculty Publications

Maternal opioid use disorder (OUD) poses substantial risks to maternal and fetal health. These adverse outcomes are believed to be mediated, in part, by changes in placental structure and function; however, few studies have addressed this question. Here, we utilized flow cytometry, histology, and spatial and single-cell transcriptomics to uncover the impact of OUD on placental tissues. Given that half of individuals with chronic OUD contract hepatitis C (HCV), we further stratified our findings by maternal HCV status. Our results indicate that OUD leads to higher incidence of vascular malperfusion accompanied by increased levels of inflammatory markers and dysregulated secretion …

Integrative Synchronicity: Learning To Hold The Space Between, Kelsey M. Bogumill

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Msw Portfolio, Kyle Dyrud

Graduate Student Portfolios, Professional Papers, and Capstone Projects

No abstract provided.

Gendered Politics Of Pictures: How Images In A Pakistani English Textbook Homogenize Female Identities, Liaquat Ali Channa

The Qualitative Report

This qualitative multimodal analytical study draws upon Kress and van Leeuwen’s ideas about pictures and problematizes textbooks of English that supposedly teach only English in Pakistan. It aims to understand the identities of an adult female as shown in the images of an English textbook. It uses Foucault’s theories of discourse and discursive formation, and a Vygotskian sociocultural view of the development of consciousness. By following Braun and Clarke (2006, 2019), all the pictures of the My English Book 4 are first analyzed thematically. Later, O’Toole’s (1994) method of analyzing pictures is employed for a detailed examination of a representative …

Modalities Of Vision Restoration In Optic Neuropathies And Retinal Disease, Batsheva Rubin, Fabio Lavinsky, Rachel Cain, Ajay E. Kuriyan, Gadi Wollstein, Ronald Zambrano, Joel Schuman

Wills Eye Hospital Papers

Visual impairment affects over 250 million people globally and carries a significant psychosocial and economic burden. In recent years, rapid advancements in biomedical engineering and regenerative medicine have driven the development of innovative therapies aimed at restoring visual function. Here, we first provide an overview of the visual pathway, imaging modalities, and the psychosocial and economic burden of vision loss. Then we review four vision restoration approaches: gene and stem cell therapies, optogenetics, retinal prosthetic devices, and visual pathway electrical stimulation. For each therapeutic approach, the mechanism of action, clinical outcomes, adverse events, and current limitations are discussed. Stem cell …

Staff Education To Improve Clinical Task Prioritization Among Outpatient Clinical Staff, Adebayo Arowolo

Walden Dissertations and Doctoral Studies

No abstract provided.

Serological Evidence Of Onchocerca Volvulus Exposure And Entomological Indicators Of Parasite Transmission, Didier Kapuku Bakajika

Walden Dissertations and Doctoral Studies

No abstract provided.

Exploring How Parental Substance Abuse Experiences Shape Black Women’S Interpersonal Relationships, Samele Mayfield

Walden Dissertations and Doctoral Studies

No abstract provided.

Development Of Novel Plasma Proteomic Biomarkers For Cancer-Associated Thrombosis In An Advanced Cancer Cohort, Preeti, Mrinal Ranjan, Dang Pham, Juan L Bueno, Micheline M Resende, Michael E Scheurer, Christopher I Amos, Chao Cheng, Ang Li

Faculty, Staff and Students Publications

Background: Existing risk models for cancer-associated thrombosis (CAT) show suboptimal performance in selective high-risk populations with cancer. Affinity-based plasma proteomics offers a novel approach for detecting CAT risk.

Objectives: To identify plasma biomarkers for CAT using proximity extension assays in an advanced cancer cohort.

Methods: We performed a nested case-control study using the Olink Explore HT panel. The final cohort included 57 patients with CAT and 113 matched control patients from 5 selected cancer types who had samples collected between cancer diagnosis and chemotherapy initiation. Random survival forest model was used to assess nonlinear associations with CAT in 5416 normalized …

Modeling Individual Self-Protective Behavior During Epidemics, Geonsik Yu, Michael J. Garee, Mario Ventresca, Yuehwern Yih

Faculty Publications

Protecting public health from infectious diseases requires collective action, as individual behaviors—such as vaccination and mask-wearing—directly influence disease dynamics. During the COVID-19 pandemic, unexpected public responses often undermined the effectiveness of interventions, highlighting the need to understand collective behavioral patterns and motivations to design more effective mitigation strategies. This study presents an agent-based simulation model that captures how individuals adjust self-protective behaviors based on evolving opinions about disease risk and examines how these decisions interact with external factors, such as public health interventions, to shape collective outcomes. To improve the representativeness of the simulated population, multiple datasets were integrated to …

Staff Education To Improve Interpretation And Documentation Of Category Ii Fetal Heart Rate Patterns In Labor And Delivery Nurses, Lizette Girado

Walden Dissertations and Doctoral Studies

No abstract provided.

Friedel–Crafts Addition Of 3-Alkylated Indoles To Aldehydes: 2-Hydroxyalkylation Promoted By Trimethylsilyl Trifluoromethanesulfonate, Eric Zhou, Helen Xia, C. Wade Downey

Chemistry Faculty Publications

In the presence of trimethylsilyl trifluoromethanesulfonate (TMSOTf) and 2,6-lutidine, 3-alkylated indoles undergo Friedel–Crafts silyloxyalkylation when treated with nonenolizable aldehydes. The reaction is general across a wide range of aromatic aldehydes and tolerates a variety of N-alkylated indoles. Deprotection of the silylated product occurs under standard conditions, and in certain cases the initial TMS-protected product can be isolated in high yield.

Proximity Data And Social Networks: A Validation Study Of Two Models Of Mobile Dataloggers In The Semi-Fossorial And Social Rodent, Octodon Degus, L. D. Hayes, A. A. Maldonado-Chaparro, Jessica Morales Valenzuela, L. Platt, L. A. Ebensperger

Biology Faculty Works

The use of mobile dataloggers to gather proximity data has generated novel insights into the social network structure of animals. The performance of mobile dataloggers may be impacted by different environmental and social conditions. Thus, validation studies that account for species-specific habitat use and behavior are essential. We conducted a series of validation studies of two brands of mobile dataloggers (Gipsy6, Technosmart, Italy; ProxLog, IoSA, Belgium) on the semi-fossorial rodent, Octodon degus. First, we determined the sensitivity of both types of dataloggers to track position and closeness in different habitats (Experiments 1 and 2). To determine if the structure …

Service-Learning In Adapted Physical Activity: Student Experiences With And Without Course Integration, Courtney Jost, Nicole Fiscella Nicole Fiscella, Roxanne Bahn-Bales, Tze-Hsuan Wang, Jennifer Beamer, Jennifer Taylor, Willie Chun Wai Leung

Educational Practices in Kinesiology

Service-learning is widely used in adapted physical activity/education (APA/APE) courses to enhance student learning through community engagement. However, limited research has explored how the presence or absence of an APA/APE course influences students’ perceived learning, confidence, and engagement in inclusive physical activity settings. This quasi-experimental, cross-sectional study examined how course-enhanced and purely experiential models of a university-based APA service-learning program, PA PALS, shaped undergraduate students’ experiences. Students (N = 58) participated; 41.4% (n = 24) were concurrently enrolled in an APA/APE course (course-enhanced group), while 58.6% (n = 34) participated as volunteers (purely experiential group). A validated …

Practicing Professional Intake Consultations With Ai: An Experiential Assignment For An Exercise Prescription Course, Mark E. Hartman

Educational Practices in Kinesiology

The purpose of this article is to describe an assignment that integrates artificial intelligence (AI) with simulation-based learning in an upper-level undergraduate exercise prescription course. A large body of evidence supports the use of simulation-based education, though due to cost and feasibility limitations, it has largely been limited to medical education. This assignment leverages AI as a scalable, low-cost simulation tool, offering exercise science students a highly realistic practice simulation that reinforces both professional reasoning and interpersonal communication skills. In this assignment, titled Simulated Exercise Consultation Using ChatGPT, students practice conducting an intake session as a personal trainer while …

Prevalence Of Adverse Events Following T-Cell Redirecting Therapies In Patients With Metastatic Castration-Resistant Prostate Cancer: A Pooled Analysis, Abhiraj Saxena, Marc Yorker, Nicholas Zorko, Vivek Narayan, Bilal Siddiqui, Biren Saraiya, William Tester, Patrick Mille, Amy Shaver, Nikita Nikita, Grace Lu-Yao, W. Kevin Kelly, Kevin K. Zarrabi

Department of Medical Oncology Faculty Papers

BACKGROUND: T-cell redirecting therapies, including T-cell engagers (TCEs) and Chimeric Antigen Receptor T-cell (CAR-T), are under investigation in metastatic castration-resistant prostate cancer (mCRPC). Despite their promising therapeutic potential, these therapies remain in early stages of development due to treatment-related adverse events (TRAEs). This study aims to quantify the frequency and severity of adverse events in clinical trials with a pooled analysis.

MATERIALS AND METHODS: A systematic search of PubMed, CINHAL, Scopus, and Ovid was conducted to identify clinical trials evaluating TCEs or CAR-T in patients with mCRPC. Types and frequencies of TRAEs were collected and analyzed using a random-effects model. …

Values-Based Clinical Ethics: A New Model Of Health And Ethics Consultation For Patients Suffering In Extremis, Adam Trainer

Electronic Theses and Dissertations

This dissertation argues that contemporary clinical ethics is inadequately equipped to support patients suffering in extremis because it relies on an insufficiently discriminating account of health and a constrained model of moral reasoning. Drawing on Bernard Lonergan, it reconceives health as an emergent, multi-layered, heuristic notion shaped by biological, psychological, social, and existential goods. On that basis, it critiques principlism’s global applicability thesis and the undergirding claim that its principles form part of the common morality, arguing that this justificatory structure is philosophically insufficient and practically limited for clinical ethics in cases marked by profound suffering, moral plurality, and normative …

Bax Activation Through The N-Terminal Bh3-Like Domains Of Vdac1 And Vdac2, Autumn A. Peters

Honors Theses

Voltage-dependent anion channels (VDACs) are central to mitochondrial function by mediating metabolite diffusion across the mitochondrial outer membrane (MOM). Two isoforms­­­­­­­­­­­,­­­­­­­­­­­­­­­­­­­­­­­­­­­­ VDACs 1 and 2, are also implicated in apoptosis based on interactions with Bcl-2 family proteins that control this process, including Bax and Bcl-xL. Activation of the pro-apoptotic protein Bax by interaction with ‘BH3-only’ proteins, such as Bim or Bid, induces MOM permeabilization to signal apoptosis, yet accumulating evidence indicates VDACs 1 and 2 may also affect Bax. We discovered that the VDAC N-terminal domains contain high sequence similarity to the conserved BH3 domains within Bcl-2 family members that …

Progressive Cardiac Phenotypes And Reduced Reversibility From Long-Term Cugexp Rna Expression In A Dm1 Mouse Model, Rong-Chi Hu, Mohammadreza Tabary, Xander Ht Wehrens, Thomas A Cooper

Faculty, Staff and Students Publications

Myotonic dystrophy type 1 (DM1) is caused by an expanded CTG repeat in the DMPK gene, resulting in mutant transcripts that form expanded CUG (CUGexp) RNA foci and sequester muscleblind-like (MBNL) RNA-binding proteins. DM1 is multisystemic, with progressive worsening of disease manifestations in affected tissues. Disease progression is attributed to somatic expansion of the CTG repeats with age, resulting in production of CUGexp RNA with enhanced intrinsic toxicity due to increased MBNL sequestration. To determine the degree to which cardiac disease progression can occur independently of repeat expansion, we used a transgenic DM1 mouse model with inducible heart-specific expression of …

Dna Methylation Signatures Associated With Bipolar Disorder In Peripheral Blood Improve Prediction Models, Markos Tesfaye, Anne-Kristin Stavrum, Kira D Höffler, Kevin S O'Connell, Friederike S David, Melanie E Garrett, Sonia Hesam-Shariati, Bronwyn J Overs, Claudia Pisanu, Luana Spano, Oliver J Watkeys, Antoine Weihs, Rafaella Ardau, Allison E Ashley-Koch, Lavinia Athanasiu, Jean C Beckham, Kyle J Bourassa, Caterina Chillotti, Srdjan Djurovic, Ole K Drange, Josef Frank, Anouar Khayachi, Nathan A Kimbrel, Lourdes Martorell, Susanne Meinert, Ingrid Melle, Gunnar Morken, Pasquale Paribello, Marco Pinna, Gloria Roberts, Guy Rouleau, Peter R Schofield, Esteban Sepúlveda, Giovanni Severino, Vidar M Steen, Frederike Stein, Fabian Streit, Va Mid-Atlantic Mirecc Workgroup, Trine Vik Lagerberg, Martin Alda, Udo Dannlowski, Andreas J Forstner, Janice M Fullerton, Hans J Grabe, Melissa J Green, Tilo Kircher, Javier Labad, Mirko Manchia, Philip B Mitchell, Jair C Soares, Alessio Squassina, Alexander Teumer, Leonardo Tondo, Elisabet Vilella, Ole A Andreassen, Boris Chaumette, Gabriel R Fries, Stephanie Le Hellard

Faculty, Staff and Student Publications

Background: Bipolar disorder (BD) is a major mood disorder influenced by both genetic and environmental factors. While DNA methylation from peripheral tissues can reflect both genetic and environmental influences and reveal insights into disease biology, it remains understudied in BD. DNA methylation signatures may complement polygenic scores (PGS) and hold potential as biomarkers. Here, we conducted the largest epigenome-wide association study (EWAS) of BD to date and evaluated the predictive value of polymethylation scores (PMS) in classifying case-control status.

Methods: DNA methylation from peripheral blood of 1729 cases and 1747 controls, comprising twelve cohorts, was obtained. We performed meta-analyses for …

Identifying Novel Gene Dysregulation Associated With Opioid Overdose Death: A Meta-Analysis Of Differential Gene Expression In Human Prefrontal Cortex, Javan K Carter, Bryan C Quach, Caryn Willis, Melyssa S Minto, Dana B Hancock, Janitza Montalvo-Ortiz, Olivia Corradin, Ryan W Logan, Consuelo Walss-Bass, Brion S Maher, Eric Otto Johnson

Faculty, Staff and Student Publications

Only recently have human postmortem brain studies of differential gene expression (DGE) associated with opioid overdose death (OOD) been published; sample sizes from these studies have been modest (N = 40-153). To increase statistical power to identify OOD-associated genes, we leveraged human prefrontal cortex RNA-seq data from four independent OOD studies and conducted a transcriptome-wide DGE meta-analysis (N = 272). Using a unified gene expression data processing and analysis framework across studies, we meta-analyzed 20, 098 genes and found 335 significant differentially expressed genes (DEGs) by OOD status (false discovery rate <  0.05). Of these, 66 DEGs were among the list of 303 genes reported as OOD-associated in prior prefrontal cortex molecular studies (e.g., genes/gene families OPRK1, NPAS4, DUSP, EGR). The remaining 269 DEGs were not previously reported (e.g., NR4A2, SYT1, HCRTR2, BDNF). There was little evidence of genetic drivers for the observed differences in gene expression between opioid addiction cases and controls. Enrichment analyses for the DEGs across molecular pathway and biological process databases highlight an interconnected set of genes and pathways linked to orexin and tyrosine kinase receptors through MEK/ERK/MAPK signaling to affect neuronal plasticity.