Digital Commons Network^™

Crossing The Home-Rule Boundaries Should Be Mandatory: Advocating For A Watershed Approach To Zoning And Land Use In Ohio, Melanie Shwab

Cleveland State Law Review

This Article advocates that Ohio adopt a mandatory “watershed-approach” to land use planning and zoning throughout the state. Ohio should adopt this approach to increase water quality in the state by reducing nonpoint source pollution, achieve greater environmental regulation uniformity, and offset the unfettered zoning power of municipalities operating in the absence of a comprehensive plan.

Vol. 35, No. 5: Holiday 2010, School Of Medicine & Health Sciences

North Dakota Medicine Archive

No abstract provided.

Winter 2010, Nsu Oceanographic Center

Currents

No abstract provided.

Book Review Of, Integrating Zooarchaeology And Paleoethnobotany: A Consideration Of Issues, Methods, And Cases, Virginia L. Butler

Anthropology Faculty Publications and Presentations

Reviews the book "Book Review of, Integrating Zooarchaeology and Paleoethnobotany: A Consideration of Issues, Methods, and Cases" by Amber M. VanDerwarker and Tanya M. Peres.

Archaeological Evidence For Resilience Of Pacific Northwest Salmon Populations And The Socioecological System Over The Last ~7,500 Years, Sarah K. Campbell, Virginia L. Butler

Anthropology Faculty Publications and Presentations

Archaeological data on the long history of interaction between indigenous people and salmon have rarely been applied to conservation management. When joined with ethnohistoric records, archaeology provides an alternative conceptual view of the potential for sustainable harvests and can suggest possible social mechanisms for managing human behavior. Review of the ~7,500-year-long fish bone record from two subregions of the Pacific Northwest shows remarkable stability in salmon use. As major changes in the ecological and social system occurred over this lengthy period, persistence in the fishery is not due simply to a lack of perturbation, but rather indicates resilience in the …

Sdrc Biennial Report 2008-2010, Connie Jan Maraan

SDRC Accomplishment Reports

No abstract provided.

Ionizing Radiation, Robert L. Brent Dr.

The Selected Works of Robert Brent

None

Expression Of The Intestinal Biomarkers Guanylyl Cyclase C And Cdx2 In Poorly Differentiated Colorectal Carcinomas., Brody Winn, Rosemarie Tavares, Andres Matoso, Lelia Noble, Jacqueline Fanion, Scott A Waldman, Murray B Resnick

Department of Pharmacology and Experimental Therapeutics Faculty Papers

Guanylyl cyclase C, a receptor for bacterial diarrheagenic enterotoxins, is expressed selectively by intestinal epithelium and is an endogenous downstream target of CDX2. The expression of Guanylyl cyclase C is preserved throughout the adenoma/carcinoma sequence in the colorectum. Detection of Guanylyl cyclase C expression by reverse transcriptase-polymerase chain reaction is currently being validated as a technique to identify occult lymph node metastases in patients with colorectal cancer and for circulating cells in the blood for postoperative surveillance. Although Guanylyl cyclase C is widely expressed by well-differentiated colorectal cancer, its expression in poorly differentiated colorectal cancer has not been evaluated. A …

2010 Sci-Tech Division Awards, Sheila Rosenthal, Hilary M. Davis

Sci-Tech News

No abstract provided.

Bilski: Assessing The Impact Of A Newly Invigorated Patent Eligibility Doctrine On The Pharmaceutical Industry And The Future Of Personalized Medicine, Christopher M. Holman

Faculty Works

The patent eligibility doctrine serves a gatekeeper role in excluding from patent protection natural phenomena, principles of nature, abstract ideas, and mental processes. Beginning around 1980, the U.S. patent system embarked upon a pronounced expansion in its definition of patent eligible subject matter, particularly with respect to software and business method inventions, but also in the life sciences. In recent years, however, we have seen a backlash, with many critics from the public and private sectors arguing that the threshold for patent eligibility needs to be raised in order to ensure that patents fulfill their constitutional objective of encouraging innovation …

Characterization Of Protein Residue Surface Accessibility Using Sequence Homology, Radhika Pallavi Mishra

Master's Theses

Residues present on the surface of the proteins are involved in a number of functions, especially in ligand-protein interactions, that are important for drug design. The residues present in the core of the protein provide stability to the protein and help in maintaining protein structure. Hence, there is a need for a binary characterization of protein residues based on their surface accessibility (surface accessible or buried). Such a classification can aid in the directed study of either residue type.

A number of methods for the prediction of surface accessible protein residues have been proposed in the past. However, most of …

Lakefront View, Melanie Marquez

USF Magazine Articles about USF St. Petersburg Campus

Mentions fieldwork by Dr. Deby Cassill, a professor environmental science and policy, and her students at Crescent Lake in St. Petersburg.

Medicinal Plants Diversity And Their Conservation Status In Wildlife Institute Of India (Wii) Campus, Dehradun, B. S. Adhikari, M. M. Babu, P. L. Saklani, G. S. Rawat

Ethnobotanical Leaflets

The present paper deals with the status and distribution pattern of medicinal plants in Wildlife Institute of India campus, Dehradun, Uttarakhand, India. Based on extensive literature survey, of the total (#605 plants) 63% are medicinal plants. These medicinal plants comprise of 63 trees, 55 shrubs, 208 herbs, 34 climbers, 3 ferns and 10 grasses belong to 94 families. Poaceae, Asteraceae, Cyperaceae and Euphorbiaceae are the largest families and have more than 20 species of medicinal plants. Fabaceae, Asteraceae, Poaceae, Euphorbiaceae, Lamiaceae, Malvaceae, Acanthaceae, Apocynaceae, Caesalpiniaceae, Verbenaceae, Cucurbitaceae and Solanaceae are the dominant families with high species diversity. The nativity of …

Fin Ray Chemistry As A Potential Natural Tag For Smallmouth Bass In Northern Illinois Rivers, Kurt T. Smith, Gregory Whitledge

Publications

Natural chemical markers in otoliths and fin rays have proven useful for describing environmental history of fishes in a variety of environments. However, no studies have evaluated smallmouth bass (Micropterus dolomieu) pectoral fin ray chemistry as a non-lethal alternative to otolith chemistry. We evaluated the trace element composition of smallmouth bass fin rays collected from northern Illinois rivers and determined the accuracy with which fish could be classified to their environment of capture using pectoral fin ray strontium:calcium (Sr:Ca) and barium:calcium (Ba:Ca) ratios. Fish were collected from nine sites during summer 2008. Fin ray Sr:Ca differed among some …

Pharmaceutical Patents, Paragraph Iv, And Pay-For-Delay: The Landscape Of Drung Patent Litigation And The Lessons Provided For The Recently Passed Biosimilar Approval Pathway, Brett Havranek

Intellectual Property Brief

No abstract provided.

Pharmaceutical Patents, Paragraph Iv, And Pay-For-Delay: The Landscape Of Drung Patent Litigation And The Lessons Provided For The Recently Passed Biosimilar Approval Pathway, Brett Havranek

Intellectual Property Brief

No abstract provided.

A Bimodal Distribution Of Two Distinct Categories Of Intrinsically Disordered Structures With Separate Functions In Fg Nucleoporins, Justin Yamada, Joshua L. Philips, Samir Patel, Gabriel Goldfien, Alison Calestagne-Morelli, Hans Huang, Ryan Reza, Justin Acheson, Viswanathan V. Krishnan, Shawn Newsam, Ajay Gopinathan, Edmond Y. Lau, Michael E. Colvin, Vladimir N. Uversky, Michael F. Rexach

Molecular Medicine Faculty Publications

Nuclear pore complexes (NPCs) gate the only conduits for nucleocytoplasmic transport in eukaryotes. Their gate is formed by nucleoporins containing large intrinsically disordered domains with multiple phenylalanine-glycine repeats (FG domains). In combination, these are hypothesized to form a structurally and chemically homogeneous network of random coils at the NPC center, which sorts macromolecules by size and hydrophobicity. Instead, we found that FG domains are structurally and chemically heterogeneous. They adopt distinct categories of intrinsically disordered structures in non-random distributions. Some adopt globular, collapsed coil configurations and are characterized by a low charge content. Others are highly charged and adopt more …

3, 4-Dihydroxyphenylacetic Acid (Dopac) Impairs Α-Synuclein Interaction With Lipids, Wenbo Zhou, Chunmei Long, Anthony L. Fink, Vladimir N. Uversky

Molecular Medicine Faculty Publications

α-Synuclein (α-Syn) is a small intrinsically disordered presynaptic protein known to form insoluble filamentous inclusions in Parkinson’s disease (PD) and other neurodegenerative disorders. Various catecholamines can inhibit the α-Syn fibrillation in vitro. Recently, non-covalent binding of DOPAC (3,4-dihydroxyphenylacetic acid), a normal product of the dopamine metabolism, was shown to inhibit the fibrillation of α-Syn due to the DOPAC-induced stabilization of the normally transient oligomers thus preventing them from subsequent fibril formation (Zhou, et al. J. Mol. Biol. 2009, 388 (3), 597-610). We are showing here that the interaction of DOPAC with α-Syn decreases the binding affinity of α- Syn to …

Executive Activism Not Reciprocated With Judicial Activism: Wyeth V. Levine And Cuomo V. Clearing House Return Preemption To The Legislative Branch, Anthony C. Coveny, Shelly A. Sanford

St. Thomas Law Review

The Supreme Court has taken a strong stand on the preemption issue, with both liberal and conservative justices agreeing to return preemptive authority to Congress. In short, the Supreme Court has properly refused to reward Executive activism with Judicial activism. This article discusses the theoretical foundation of preemption; the requirement of clear Congressional intent; recent Executive Branch attempts to push preemption vis-d-vis agency regulation; the Supreme Court's refusal to reward Executive activism with Judicial activism in Wyeth v. Levine and Cuomo v. Clearing House Ass'n, L.L. C.; and the preemption landscape as it exists in 2009 going forward.

What Are The Policy Implications Of Use Of Epidemiological Evidence In Mass Torts And Public Health Litigation, Christopher Ogolla

St. Thomas Law Review

The distinctions between the standards of proof employed in epidemiology and in law inform the central thesis of this paper. This analysis began by describing the role of epidemiology in mass torts and public health litigation. It later argues that because mass torts cover such a wide area, there are several problems related to epidemiology in litigation, particularly scientific uncertainty and inconsistent factual claims. Part II discusses recent cases where epidemiological evidence was raised and debated, distinguishing between vaccine-related and non-vaccine-related cases. Courts have differentiated vaccine-related cases from non-vaccine-related cases, principally because Congress enacted a vaccine act designed to compensate …

Effects Of Various Flavonoids On The Α-Synuclein Fibrillation Process, Xiaoyun Meng, Larissa A. Munishkina, Anthony L. Fink, Vladimir N. Uversky

Molecular Medicine Faculty Publications

α-Synuclein aggregation and fibrillation are closely associated with the formation of Lewy bodies in neurons and are implicated in the causative pathogenesis of Parkinson's disease and other synucleinopathies. Currently, there is no approved therapeutic agent directed toward preventing the protein aggregation, which has been recently shown to have a key role in the cytotoxic nature of amyloidogenic proteins. Flavonoids, known as plant pigments, belong to a broad family of polyphenolic compounds. Over 4,000 flavonoids have been identified from various plants and foodstuffs derived from plants and have been demonstrated as potential neuroprotective agents. In this study 48 flavonoids belonging to …

Library Newsletter Volume 6, Issue 1

Library Newsletters

No abstract provided.

The M-Superfamily Of Conotoxins: A Review, Reed B. Jacob, Owen M. Mcdougal

Chemistry and Biochemistry Faculty Publications and Presentations

Throughout the world there exist both predator and prey. This distinction is apparent though sometimes misleading. Take for example marine snails of the genus Conus that are present across the oceans of the southern hemisphere [1]. These snails are slow moving animals that appear more prey than predator. However, they have evolved into effective predators through the development of venom consisting of biologically active peptides. The venom is loaded into a hollow harpoon that the snail injects into the intended prey: fish, worms, or other snails [2]. The categories of cone snails based on prey preference are piscivorous (fish eating), …

Historical Consciousness And Ethnicity: How Signifying The Past Influences The Fluctuations In Ethnic Boundary Maintenance, Paul Zanazanian

Ethnic Studies Review

Theorists tend to limit 'history's' role in the dynamics of ethnicity to that generally played by collective memory. By bringing the notion of historical consciousness to the fore, new possibilities may, however, emerge for discerning how history, as one cultural mode of remembering among many others, impacts both ethnicity delineations and fluctuations in boundary maintenance. In encapsulating the many forms of commemoration as well as the different dimensions of historical thinking, the contribution of historical consciousness accordingly lies on how group members historicize temporal change for moral orientation in time. By likewise signifying past events for negotiating their ethnicity and …

Chicano/Mexican "Culture" As A Rational Instrument In The Human Sciences, Alexandro José Gradilla

Ethnic Studies Review

The use of "culture" as an analytical category by social scientists presents an opportunity to examine how professional discursive formations are used to make empirical assertions. The social fact of culture is neither uniform nor unitary. Traditionally, culture has been thought of as a product of disciplinary research, not necessarily a variable for empirical study. When culture is used as a tool or instrument of scientific methodology, it loses its fluid nature as a disciplinary discourse. In this essay, I examine the specific discussion of the epidemiologic health paradox that states that the Chicano/Mexican immigrant "culture" serves as a protective …

The Roles Of Rhle And Hfq In Srna-Dependent Gene Regulation, Abeykoon Jayalath Iresha Sandeepanie Rathnayake

Wayne State University Theses

THE ROLES OF RHLE AND HFQ IN SRNA-DEPENDENT GENE REGULATION

by

ABEYKOON JAYALATH IRESHA SANDEEPANIE RATHNAYAKE

DECEMBER 2010

Advisor: Dr. Andrew Feig

Major: Chemistry

Degree: Master of Science

Bacteria are adapted to live in diverse environmental conditions. Thus, they show excellent tolerance and response to extreme environmental conditions caused by low or high temperatures, high salinity, reactive oxygen species or high nutrient concentrations. sRNAs have been identified and characterized as cis-acting or trans-acting post-transcriptional regulators in diverse cellular processes including virulence and adaptation to environmental stress (11,12,14,15). Interactions of sRNAs and target mRNAs result in translational repression, translational activation or/and …

Doing Ethnography In An Urban Hospital Emergency Department Setting: Understanding How Culture Was Related To Emergency Physician Habitus, Renady Hightower

Wayne State University Dissertations

This hospital ethnography focused on the relationship between culture and emergency physician habitus. The habitus of these physicians was defined as those routine, patterned forms of behaviors and practices performed by the physicians while in the emergency department and while interacting with the patient during the physician-patient interaction. Pierre Bourdieu's practice theory was used to address how culture was related to the habitus of the emergency physician. The researcher found that culture was not only related to the habitus of these physicians, but it reproduced, and at times created, aspects of the habitus through the practices performed while in the …

Application Of Magnetic Resonance Imaging To Understanding The Pathogenesis Of The X-Linked Leukodystrophy Pelizaeus-Merzbacher Disease, Jeremy Jerome Laukka

Wayne State University Dissertations

Myelin is a multilamellar membrane structure surrounding axons in both the CNS and PNS that facilitates nerve conduction. In the CNS, myelin is synthesized by oligodendrocytes, while in the PNS, myelin is synthesized by Schwann cells. In the CNS, Proteolipid protein 1 (PLP1), an integral membrane protein, is the major protein component of myelin, constituting ~50% of myelin protein. Mutations of the PLP1 gene in man cause a spectrum of neurological disease, ranging from the severe Pelizaeus-Merzbacher disease (PMD), that typically begins during infancy with nystagmus, seizures and hypotonia and evolves into spastic quadriparesis, cognitive impairment and ataxia, to ¡¥pure¡¦ …

Creg1 And Its Enhancement Of P16ink4a-Induced Senescence, Benchamart Moolmuang

Wayne State University Dissertations

Bypassing cellular senescence, an irreversible growth arrest of cells that is activated in normal cells to become immortal is one of the prerequisites for carcinogenesis. Cellular senescence can be triggered by shortening of telomeres and certain cellular stresses. Using spontaneously immortalized Li-Fraumeni Syndrome (LFS) fibroblasts, we found that CREG1 (Cellular Repressor of E1A-stimulated Genes1) is one of genes whose expression fit the criteria of senescence-associated genes, decreased expression during immortalization and increased in senescence. Moreover, we found that epigenetic mechanisms regulate CREG1 expression in LFS fibroblasts. CREG1 is a secreted glycoprotein that was shown to bind Rb-family pocket proteins and …

Feminine Beauty Norms And The Media: A Content Analysis Of A Popular Tween Magazine, Victoria Velding

Wayne State University Theses

The term “tween” is rather new and has become widely used in mainstream culture. In terms of how this term is constructed, today’s tween is overwhelmingly female rather than male. Girls are expected to look and act a certain way because of societal beauty norms, which they can learn about via mainstream media, parents, teachers, peers, and other sources of socialization. So far, little research has focused on magazines whose target audience is the younger teen and tween; that is, girls who are roughly 8 to 14 years of age. This research consisted of a content analysis of advertisements found …