Digital Commons Network^™

A Chemogenetic Approach For Temporal And Cell-Specific Activation Of Endogenous Gpcrs In Vivo, Gwendolyn Shingles, Qianqian Pang, Jian Weng, Ryan Singer, Waleed Babar, Jiaqi Shen, Luis Vazquez-Rivera, Yao Chen, Peng Li, Wenjing Wang

2020-Current year OA Pubs

Cell-specific regulation of endogenous G protein-coupled receptors (GPCRs) is crucial for understanding their roles in physiological processes. We present chemogenetic tools using shield-1-dependent irreversible protein switches to regulate peptide agonist activity. To demonstrate this platform, we engineered chemogenetically regulated pituitary adenylate cyclase activating polypeptide (cPACAP), which exhibited >15-fold chemical-dependent regulation of endogenous receptor activity. In vivo application of cPACAP allowed neuronal activation via the endogenous receptor for PACAP, engaging neural circuits that control respiratory and feeding behaviors. By integrating cPACAP with transgenic mice, we selectively activated endogenous PACAP receptor signaling in hypocretin-expressing neurons of the lateral hypothalamic area (LHA), revealing …

The Biomedical Landscape Of Genomic Structural Variation In The Qatari Population, Elbay Aliyev, Najeeb Syed, Alessia Visconti, Taghi Aliyev, Aziz Belkadi, Mohammadmersad Ghorbani, Niccolò Rossi, Haroon Naeem, Geethanjali Devadoss Gandhi, Gaurav Thareja, Aljazi Al-Maraghi, Waleed Aamer, Amal Abdulsalam Ibrahim, Rulan Shaath, Farooq Omar Al-Ajli, Rozaimi Mohamad Razali, Fritz J Sedlazeck, Sonia Davila, Ammira Akil, Karsten Suhre, Younes Mokrab, Mario Falchi, Khalid A Fakhro

Faculty, Staff and Students Publications

We present a large-scale study of structural variation (SV) in the Qatari population, based on short-read whole-genome sequencing (WGS) of 6,141 individuals, identifying 153,946 variants across 5 classes reflecting the region's diversity and evolutionary history. Leveraging consanguinity and biobank phenotypes, we identify >180 putative gene knockouts, and use proteomics to show functional consequences in homozygotes. Conversely, 52 genes show significant depletion of homozygous deletions, eight of which cause severe pediatric disease or murine embryonic lethality. Examining phenotypic extremes uncovers several non-exonic homozygous deletions with large effect, including in SPIRE2 (creatinine), MAGI2 (leanness) and a chr19 microRNA cluster (extreme obesity). Further, …

Fear Of Falling: A Collaborative Approach To Treatment, Alexandra Uhren, Celeste Delap, Kate Jansen

Journal of Interprofessional Practice and Collaboration

Purpose: Physical Therapy (PT) and Behavioral Health (BH) often overlap in patient care; however, collaborative treatment is always not utilized by providers. This case study details the interdisciplinary treatment of a 69-year-old female with a fear of falling; emphasizing the importance of interprofessional collaborative care in treating Fear of Falling (FOF) in individuals at risk for fall-related injury with Cognitive Behavioral Therapy (CBT) and PT interventions.

Problem: FOF is common among older adults and can result in physical, psychological, and social consequences (Lee & Tak, 2023; MacKay et al., 2021). Patients at risk of fall-related injury experience decreased self-confidence in …

Treatment For Women With Mental Health Disorders Associated With Reproductive Health: An Opportunity For Interprofessional Collaboration, Ellen Modlin Phd, Otr/L, Bcp, Caps, Deana Goldin Phd, Dnp, Arnp, Fnp-Bc, Pmhnp-Bc

Journal of Interprofessional Practice and Collaboration

Abstract

Purpose: This article proposes an opportunity for interprofessional collaboration between mental health practitioners (MHPs) and occupational therapy practitioners (OTPs) for the treatment of women experiencing mental health disorders (MHDs) associated with reproductive health (RH) changes throughout the lifespan. This collaborative approach have the potential to optimize women’s health care and mitigate the risk of fragmented care, as these conditions are highly complex.

Method: Peer- reviewed literature from mental health and occupational therapy (OT) research was reviewed and summarized. The search focused on the barriers and potential opportunities for collaboration between MHPs and OTPs in women affected with MHDs associated …

From Asylums To Hospitals To Prisons: The History Of Institutional Psychiatric Care In America, Mary E. Horton

History of Medicine Seminar

No abstract provided.

Cultivating Global Citizenship At Home: A Content Analysis Of Collaborative Online International Learning (Coil), Allison Freed, Evan W. Faidley, Valerie G. Couture, K. Adele Okoli, Leticia De La Garza, Adriian Gardner, Crystal Harris, Leah Horton, Brittany N. Saviers, Sunjung Kim Thao, Amber Wilson

International Journal of Transformative Teaching and Learning in Higher Education

This study presents a content analysis of scholarly works on collaborative online international learning (COIL) published between 2015 and 2023. Conducted by an interdisciplinary faculty group, the research explores how COIL literature frames student learning outcomes within internationalization-at-home efforts. Findings reveal that COIL most frequently supports assignments/projects, as well as intercultural communication and global competence, particularly at the undergraduate level. The analysis highlights COIL’s potential to democratize global learning by addressing access barriers for both students and faculty. The study calls for expanded research on the long-term impacts of COIL, inclusive pedagogies, and cross-institutional collaborations to advance global citizenship in …

Cyborg Feminism And Toxic Colonialism In Chen Qiufan’S Waste Tide, Yuan Yuan

CLCWeb: Comparative Literature and Culture

The article probes into the interrelationships among cyborg technology, sexual violence, and toxic colonialism represented in the Chinese SF novel Waste Tide by Chen Qiufan. It applies methodologies in posthumanism and ecofeminism and situates the text in the Chinese as well as a global context. It intends to provide a non-Western perspective to understand cyborg feminism by associating the Chinese historical reality with trans-species thinking. It argues that the SF author Chen Qiufan is critical about the anthropogenic body modifications which may challenge the process of female resistance and resilience in the face of gender and colonial oppression. By doing …

Deep Learning For Manufacturing: Surface Roughness Prediction In Cnc Turning Via 1d Cnn, Amar Awad Mohammad Al-Sumaidaee

Engineering and Technology Journal

Optimisation of machining parameters is crucial to achieve an excellent surface finish, with surface roughness serving as the primary indicator of product quality. This study investigates the application of a one-dimensional Convolutional Neural Network (1D CNN) to predict surface roughness in Computer Numerical Control (CNC) turning processes. In contrast to conventional machine learning methods, the proposed CNN captures local dependencies within the tabulated input features, which include cutting speed, feed rate, depth of cut, and force components (Fx, Fy, Fz, and resultant force). A laboratory data set was used for model training, with the mean square error serving as the …

Enhancing Solar Desalination Performance Through Pcms, Nanomaterials, And Intelligent Control: A Review Of Integrated Approaches, Malak M. Alobaidy, Hussein T. Rishag, Muna S. Kassim

Engineering and Technology Journal

Solar desalination utilizing Phase Change Materials (PCMs) and nanomaterials offers promising avenues for water purification. Still, challenges must be addressed: PCM limitations include low thermal conductivity, supercooling, corrosion, and leakage, while nanomaterial challenges include stability, aggregation, toxicity, and scalability. System integration and performance include complexity, hybrid optimization, fouling, scaling, and durability. Intelligence can enhance the thermal work of systems with still water by enabling smarter design and control. This system relies on robust monitoring to provide data for analysis, optimization, and efficient operation. Monitoring is indispensable for reviewing and improving such systems. Freshwater scarcity is a global issue, especially in …

Combined Effect Of Collector Design And Nanofluid On The Photovoltaic/Thermal System Cooling Under Hot Summer Iraqi Conditions, Hussain M. Hamed, Sattar Aljabair, Ahmed A. Imrana

Engineering and Technology Journal

The operation of photovoltaic/thermal (PV/T) systems is highly susceptible to the operating temperature of the photovoltaic (PV) panel, as elevated temperatures significantly reduce electrical efficiency and overall system performance. To address this critical issue, a PV/T system incorporating a serpentine channel with fins was carefully designed and experimentally tested using water and Al₂O₃/water nanofluids at 0.25 and 0.5%. The system’s thermal, electrical, and exergy efficiencies were systematically evaluated under different cooling conditions, along with detailed analyses of entropy generation and exergy losses. Experimental results indicated that electrical efficiency improved by 12.4, 16.1, and 22.2% when using …

Recent Advances In Modeling And Applications Of Magnetorheological Elastomer Composites: A Review, Sinaa S. Hafidh, Mohsin N. Hamzah, Muthanna H. Sadoon

Engineering and Technology Journal

Magnetorheological elastomer (MRE) composites are particularly effective materials for applications like vibration absorption and damping in mechanical systems because external magnetic fields modify their mechanical properties. The main topic of this review is the study of MRE composites’ rheological properties-such as their dispersion, organization, and surface features within an elastomer matrix-and how these aspects affect their mechanical performance in the presence of magnetic fields. The study explores the internal microstructures, filler-matrix adhesion, and viscoelastic behavior of MRE composites under different stresses, such as static, compressive, and dynamic. MREs are famous for their capacity to modify mechanical characteristics (such as stiffness …

Direct Effects Of Capsaicin On Voltage-Dependent Calcium Channels Of Mammalian Skeletal Muscle, Dmytro Isaev, Tatiana Prytkova, Badarunnisa Mohamed, Mohamed Omar Mahgoub, Keun-Hang Susan Yang, Murat Oz

Pharmacy Faculty Articles and Research

Capsaicin, a naturally occurring polyphenol, is known to affect energy expenditure and muscle fatigue and modulate contractions in skeletal muscle. The L-type Ca²⁺ channels are known to be an important ion channel involved in the various muscle functions and the effect of capsaicin on the skeletal L-type Ca²⁺ channels is currently unknown. In this study, the effects of capsaicin and capsaicin analogs on depolarization-induced Ca²⁺ effluxes through L-type Ca²⁺ channels in transverse tubule membranes from rabbit skeletal muscle and L-type Ca²⁺ currents recorded using the whole-cell patch clamp technique in rat myotubes were examined. Capsaicin, …

High-Sensitivity Cardiac Troponin I And Frailty: Associations With The Frailty Index And Fried Phenotype In Older Women, Jedd Pratt, Abadi K. Gebre, Carlos J. Toro-Huamanchumo, Elsa Dent, Trent Bozanich, Wai E. Lim, Elizabeth Byrnes, Julee Mcdonagh, Caleb Ferguson, Craig Sale, Kun Zhu, Carl Schultz, Richard L. Prince, Joshua R. Lewis, Marc Sim

Research outputs 2022 to 2026

Despite the nexus between cardiovascular health and frailty, the relevance of high-sensitivity cardiac troponin I (hs-cTnI), a biomarker of myocardial injury, to frailty is poorly understood. We examined whether hs-cTnI concentrations were associated with frailty in a well-characterized cohort of older women. A total of 1151 community-dwelling women from the Perth Longitudinal Study of Aging Women (mean age ± SD = 75.2 ± 2.7 years) were included. Frailty was operationalized using a validated frailty index (FI) of cumulative deficits and a modified Fried phenotype. Plasma hs-cTnI were categorized into quartiles. Cross-sectional associations between hs-cTnI quartiles and frailty were assessed using …

Reformulation Of The Protein Databank For Real-Time Search Of Geometrical Attributes Of Protein Structures, Musa Azeem, Christopher Lee, Aaron Hein, Christopher Ott, Homayoun Valafar

Faculty Publications

Introduction:

In this study, we introduce the design and implementation of PDBMine, a large-scale, queryable platform for mining sequence-structure statistics from the Protein Data Bank (PDB). PDBMine enables rapid analysis of local conformational trends across proteins by extracting dihedral angles and sequence patterns at scale. In addition to the design and implementation of PDBMine, we also present results validating its ability to return structurally meaningful information.

Methods:

We first assess the accuracy of its dihedral angle distributions by comparing them to established Ramachandran space and verifying expected behaviors of residues such as glycine and proline. We then use PDBMine to …

Global Insight 2026, Masey Smith, Chance Carden, Hayley Pounds

Books

Global Insight 2026 is the annual publication of the International Institute at Mississippi State University, documenting the university’s global engagement across education, research, service, and institutional partnerships. This issue highlights Mississippi State University’s international impact through faculty‑led study abroad programs, international research and development initiatives, global fellowships, and comprehensive international student support services. Featured content includes narrative case studies of student and faculty experiences abroad, data‑driven insights into study abroad participation and international enrollment trends, and in‑depth examinations of international research collaborations spanning Africa, Latin America, Europe, and Asia. The magazine also showcases the work of the English Language Institute …

Rules Of The Game: Lessons From Sports To Understand Antitrust Law’S Fairness Foundations, Tara Pincock, Daniel A. Hanley

Washington and Lee Law Review Online

Traditionally, courts and practitioners assert that the antitrust laws are simply about protecting competition, not competitors. In essence, these parties perceive competition to be inherently desirable, rather than recognizing that it can be beneficial or harmful depending on its intensity and scope. As a result of this mistaken belief, courts hold that certain conduct is legal under the antitrust laws simply because they determine it to be procompetitive, while conduct deemed anticompetitive is condemned. Courts seldom provide definitive boundaries to this pro-competition trope and instead assert it as if it were a well-established truism and universal societal good.

Without details …

Comparative Evolution Of Caenorhabditis Hermaphrodites, James Francis Kennedy

Theses and Dissertations

The Caenorhabditis genus produced three independently-evolved hermaphroditic species, C. elegans, C. briggsae, and C. tropicalis. This convergence happened by the independent co-option of male programs for use in a female body. This required two distinct steps: (1) mutations in the sex-determination pathway that activated spermatogenesis in XX animals, and (2) mutations that expressed one of the redundant sperm activation signals in XX animals. My project focused on characterizing how sex-determination genes work in C. briggsae and C. tropicalis. Loss-of-function alleles were used to compare the core sex-determination pathway to that of C. elegans. I found that the somatic sex-determination pathway …

Contribution To The Chemotherapy Of Human Trypanosomiasis: Design, Synthesis, And Biological Evaluation Of Dimeric 2-Nitroimidazoles Against Trypanosoma Cruzi Amastigotes And Bloodstream Trypanosoma Brucei, Afonso Santine M.M. Velez, Otavio Augusto Chaves, Carlos Serpa, Fatma M. Salem, Bibo Li Ph.D., Bin Su Ph.D., Celio Geraldo Freire-De-Lima, Debra Decote-Ricardo, Marco Edilson Freire De Lima

Biological, Geological, and Environmental Faculty Publications

Effective and safe treatments for neglected tropical diseases caused by parasites, such as Chagas disease and sleeping sickness, remain lacking, posing a significant challenge for researchers worldwide. The rational design of dimeric compounds inspired solely by the pharmacophoric core of benznidazole (2-nitroimidazole) has proven to be a promising strategy for antiparasitic development. Thus, in the present work, it was increased the linker between the active units (2-nitroimidazole) to improve the interaction with TcNTR, facilitating the bioactivation of the longest dimers. Biological assays confirmed this, demonstrating that all compounds were active against replicative intracellular amastigotes of Trypanosoma cruzi (Tulahuen C2C4-LacZ). Notably, …

Densest Subgraph Discovery On The Cpu, Hunter Gerard Gareau

Theses and Dissertations

The Densest Subgraph Discovery (DSD) problem is a prevalent problem in the field of graph mining, aiming to find the cohesive subgraph. Given a graph �� = (��,��) and an integer �� ≥ 2, the goal is to find a vertex sub- set �� ⊆ �� whose induced subgraph �� (��) maximizes the ��-clique density, defined as the number of ��-cliques per vertex. Larger val- ues of �� capture higher-order connectivity patterns beyond edges, enabling the discovery of more cohesive structures. There have been many solutions to this problem. However, one avenue that other graph mining problems have gone down …

A Human-Centric Framework: Employment Principles For Lethal Autonomous Weapons, Brennan Deveraux

Books, Monographs & Collaborative Studies

This monograph challenges the Department of War to reframe the conversation about humans’ involvement in lethal autonomous weapons systems by codifying a human-centric framework built on the employment pillars of certification, authority, restriction, and accountability. Although an ample body of literature discusses lethal autonomous weapon systems, this monograph takes a novel approach by proposing a theoretical framework and applying it to historical and hypothetical practical scenarios involving weapons with autonomous characteristics. In terms of methodology, the monograph relies heavily on primary sources, including UN documents and Department of War publications, which are augmented by secondary sources from experts in the …

Employing Ai Tools To Predict Features For Dental Care Use In The United States During The Global Respiratory Illness Outbreak, Preeti Pushpalata Zanwar, Hamid-Reza Kodan-Ghadr, Vijayakumar Thirumalai, Suad Ghaddar, Shuo Jim Huang, Beth Harkness, Eben Rey, Romanch Shah, Sairaja Reddy Kurelli, Jay S. Patel

Health & Biomedical Sciences Faculty Publications

No abstract provided.

Intouch Week Of January 12, 2026, New York Medical College

InTouch

• Department of Cell and Molecular Physiology Unites Three Disciplines
• Paul Arnaboldi, Ph.D., Receives More Than $500,000 NIH Grant to Support Respiratory Vaccine Development
• Action speaks louder than words in dealing with antisemitism and violence
• Celebrate the Publication of the 8th Edition Principles and Practice of Radiation Oncology
• Gabriel Project Mumbai, Welcomes Second Cohort of TCDM Students and Faculty
• Love at NYMC
• Student Spotlight: A Full-Circle Journey

Alcohol And The Endocrine System: A Critical Review Of Disruptions, Potential Mechanisms, And Health Implications, Patricia E. Molina, Liz Simon

School of Graduate Studies Faculty Publications

The endocrine system coordinates and integrates cellular activity throughout the body by regulating cellular and organ function and maintaining homeostasis. Homeostasis, the dynamic maintenance of internal balance despite changing external or internal conditions, is essential for proper cellular function. The endocrine system achieves this through a complex regulatory network of hormone-mediated signaling among multiple endocrine organs, relying on precisely regulated synthesis and release of hormones and specific hormone-receptor interactions. Endocrine-mediated actions coordinate critical physiological processes, including growth, metabolism, reproduction, stress adaptation, and circadian rhythms throughout the lifespan. Endocrine glands—such as the hypothalamus, pituitary, thyroid, parathyroid glands, pancreas, adrenal glands, and …

Dynamic Fib-4 Score Changes And Hcc Risk In Patients With Masld And Elevated Liver Enzymes: A Nationwide Cohort Study, Yee Hui Yeo, Hsiu J Ho, Tsai-Wei Huang, Teng-Yu Lee, Ju Dong Yang, George Cholankeril, Chien-Jen Chen, Hawi-I Yang, Chuen-Fei Chen, Hung-Chuen Chang, Chun-Ying Wu

Faculty, Staff and Students Publications

Introduction: Hepatocellular carcinoma (HCC) can develop in individuals with metabolic dysfunction-associated steatotic liver disease (MASLD) without cirrhosis, especially in those with elevated liver enzymes. However, there is currently no low-cost, scalable screening tool for this population. To address this need, we investigated the association between serial changes in FIB-4 (fibrosis-4) scores over a 3-year period and the risk of developing HCC in a large, diverse cohort of patients with MASLD without cirrhosis.

Methods: This study utilized a nationwide cohort from the National Health Insurance Research Database (NHIRD), including 810,698 patients with MASLD who had demographic and laboratory data at baseline …

Psychological Experiences Of Law Enforcement Officers Responding To Critical Incidents Alone And With A Partner, Lydia Abernethy

Walden Dissertations and Doctoral Studies

The role of law enforcement officers is to restore peace and safety when chaos occurs, which can be life-threatening and stressful as officers respond to the critical incidents unfolding. For this study, a qualitative approach and phenomenological framework were utilized to gain insight into the first-hand psychological experiences of officers responding to critical incidents. Police officers work in demanding environments that can lead to mental health conditions such as depression and post-traumatic stress disorder. Peer support and communication among coworkers have emerged as a potentially important factor, as officers would share traumatic events with other officers. Therefore, my research focused …

Assessing Localized Recovery And Synchrony Of An Endangered Wetland Species., Aiyana Reissman

Theses

The state and federally endangered light-footed Ridgway’s rail (LFRR; Rallus obsoletus levipes) is central to regional conservation, yet the drivers of its population fluctuations remain poorly understood. The fragmented nature of coastal wetlands in Southern California is threatening the existence of endemic species like the LFRR. Tidal inundation, severe storms, and overpredation threaten the survival of LFRR. This study addresses population fluctuations by analyzing the spatial and temporal drivers of LFRR populations to inform effective, site-specific management.

To do this, a 45-year (1980–2024) LFRR census data set across 16 wetlands throughout its range in California was synthesized. A multi-faceted …

Changes In Phenology Mediate Vertebrate Population Responses To Temperature Globally, Viktoriia Radchuk, Carys V. Jones, Nina Mclean, Anne Charmantier, Céline Teplitsky, Ray Alisauskas, Sergio Ancona, Tycho Anker-Nilssen, Peter Arcese, Karl S. Berg

School of Integrative Biological & Chemical Sciences Faculty Publications

Phenotypic responses to climate affect individual fitness, but the extent to which this translates into effects on population dynamics remains poorly understood. We assemble 213 time series on phenotypes and population sizes of wild vertebrates globally and match them with local climate data. Our meta-analysis shows that morphological traits are mostly climate insensitive. However, phenology is earlier in warmer-than-average years, which contributes positively to population growth in most species. At lower latitudes, temperature has weaker effects on phenology but stronger direct negative effects on population growth, likely because these populations are less capable of tracking climate via plasticity. Variation in …

Self-Efficacy Change Among Diverse Family Caregivers In Dementia Care, Deborah M Oyeyemi, Erich J Greene, Yunshan Xu, David R Lee, Rafael Samper-Ternent, Maya L Lichtenstein, Alan Stevens, Jeff D Williamson, Arun S Karlamangla, Debra Saliba, David B Reuben

Faculty, Staff and Student Publications

Objectives: To determine whether changes in caregiver self-efficacy (beliefs about one's ability to manage dementia-related problems and access help) differed by caregiver race and ethnicity across all participants enrolled in a large pragmatic trial of comprehensive dementia care.

Methods: In the Dementia Care Study (D-CARE), community-dwelling older adults with dementia and their unpaid family caregivers were randomized to receive usual care, community-based, or health system-based comprehensive dementia care. Caregiver self-efficacy was assessed at baseline, 6 months, and 18 months using a 4-item scale (range 4-20, higher scores indicate greater self-efficacy). Among all caregivers, we compared least squares means for overall …

Fda Policy Shift On Clinical Efficacy Study Requirements For Monoclonal Antibody Biosimilars, Rileigh Rahrig, Madilyn Paphanchith, Allie Honigford, Daniella Egbujor, Haley Brown, Jenny Magana Figueroa, Connor Dains, Brenna Hissong, Kyle W. Parker

Pharmacy and Wellness Review

Biologic products are widely used in the treatment of various disease states, including rheumatoid arthritis, inflammatory bowel disease, cancers, and genetic diseases. These products are derived from proteins and genes produced by living organisms and are subsequently used to treat specific disease states. Due to the complexity of biological products, the costs of research and production are high. Currently, the United States approval pathway requires extensive testing for biologics to be designated as biosimilars, meaning there are no clinically meaningful differences in safety or purity of their active components. These required tests can be redundant, as biosimilars are developed using …

Chek2 Loss Endows Chemotherapy Resistance To Hematopoietic Stem Cells, Jing Zhou, Tianyuan Hu, Dian Li, Sanming Li, Minhua Li, Xiangguo Shi, Daisuke Nakada

Faculty, Staff and Students Publications

Individuals with history of chemo- or radiotherapy frequently exhibit somatic mosaicism in the blood, often involving mutations in genes responsible for DNA damage responses (DDR), such as CHEK2. However, the mechanisms by which CHEK2 mutations promote the expansion of mutant cells following chemo- or radiotherapy remain poorly understood. Here, we demonstrate that loss of CHEK2 confers resistance to chemotherapy in hematopoietic stem and progenitor cells (HSPCs). Through a CRISPR-based screen, we identified CHEK2 as a gene whose loss enhances resistance to cytotoxic chemotherapies. A complementary drug screen revealed that CHEK2-mutant cells are also resistant to DNA hypomethylating agents. Chek2-deficient HSPCs …