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2009

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Collaboration As Paradox : The Case Of The Patuxent River, Md Nutrient Control Strategy, Morris Bidjerano Jan 2009

Collaboration As Paradox : The Case Of The Patuxent River, Md Nutrient Control Strategy, Morris Bidjerano

Legacy Theses & Dissertations (2009 - 2024)

Collaboration has increasingly emerged in recent years as a new paradigm in public management. This collaborative trend, however, has contradicted the longstanding American political tradition of conflictual contestation of competing interests and adversarial legalism. Consequently, it has presented public managers with the challenge of dealing in reality with the "tensions between alternative forms of management practice" (Huxham and Vangen 2005, 245). In most accounts, watershed management has recently become a particularly active arena for that clash of opposing collaborative and conflictual managerial practices.

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The Effects, Brain Targets, And Mechanisms Of Estradiol For Affective Behavior, Alicia Ann Walf Jan 2009

The Effects, Brain Targets, And Mechanisms Of Estradiol For Affective Behavior, Alicia Ann Walf

Legacy Theses & Dissertations (2009 - 2024)

Although estradiol (E2) has numerous effects in the central nervous system, this review will focus on addressing the effects of E2 on behaviors related to mood in women and animal models and include recent findings from our laboratory related to this topic. E2's anti-anxiety and anti-depressant-like effects may depend upon many factors (e.g. age, reproductive history/status, time in E2 deficient state before initiation of E2 therapy, regimen and dosing of E2, neuropsychiatric/stress history). First, evidence of how factors may alter responses to E2 in people and in animal models will be discussed. Second, interactions of E2 with the hypothalamic-pituitary-adrenal axis/stress …

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Live-Cell Studies On Mitotic Slippage In Humans, Daniela A. Brito Jan 2009

Live-Cell Studies On Mitotic Slippage In Humans, Daniela A. Brito

Legacy Theses & Dissertations (2009 - 2024)

Checkpoints are regulatory pathways that control the order and timing of specific cell-cycle events. In the presence of unattached/weakly-attached kinetochores, the mitotic checkpoint (MC) arrests cells in mitosis by inhibiting the degradation of cyclin B, the regulatory subunit of Cdk1 (cyclin dependent kinase 1). Checkpoints do not arrest cells permanently, and escaping mitosis with an unsatisfied MC requires cyclin B/Cdk1 inactivation. In yeast, this occurs through an “adaptation” mechanism involving inhibitory phosphorylations and/or Cdk1-inhibitors. To determine how vertebrate cells escape mitosis when the MC cannot be satisfied I conducted live-cell imaging and immunofluorescence studies on nocodazole-treated rat kangaroo (PtK) and …

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Effect Of Anti-Lipopolysaccharide Iga Antibodies On The Virulence And Physiology Of Salmonella Enterica And Shigella Flexneri, Stephen J. Forbes Jan 2009

Effect Of Anti-Lipopolysaccharide Iga Antibodies On The Virulence And Physiology Of Salmonella Enterica And Shigella Flexneri, Stephen J. Forbes

Legacy Theses & Dissertations (2009 - 2024)

Secretory IgA (SIgA) antibodies directed against the serotype-specific, O-antigen of lipopolysaccharide (LPS) are the primary determinants of mucosal immunity to enteric bacterial pathogens, including of Salmonella enterica serovar Typhimurium and Shigella flexneri. While the singular importance of SIgA in preventing enteric infections is recognized, the underlying mechanisms by which these antibodies protect the mucosal epithelium remains poorly understood. In this study, I demonstrated that Sal4, a protective, anti-LPS specific monoclonal IgA, is a potent inhibitor of S. Typhimurium flagella-based motility and type three secretion (T3S) mediated entry into epithelial cells. Sal4's effects on motility and invasion occurred rapidly (<15 min), and were independent of agglutination. I also present evidence the protective anti-LPS, monoclonal IgA, IgAC5, reduced S. flexneri T3S of IpaB and IpaC. Concurrent with the IgA-induced reduction in T3S, there was a decrease in both the proton motive force and ATP levels in both bacterial species examined. I also report that Sal4 and IgAC5 have effects on the bacterial envelope. Scanning, transmission, and cyro-electron microscopy revealed dramatic antibody-mediated alterations in the topology of the outer membrane (OM) of S.Typhimurium and S. flexneri. Furthermore, Sal4-treatment caused a ~5 fold increase in O-antigen, and elevated levels of lipid A, released into culture supernatants, consistent with the loss of LPS. Correspondingly, the OM of antibody-treated bacteria was ~50% more permeable than control cells. Based on these data, I proposed that Sal4 binding to the LPS destabilizes the outer leaflet of the OM of S. Typhimurium, thereby compromising the integrity of the bacterial envelope, disrupting bioenergetics by physical and/or mechanical stress, and arresting both flagella-based motility and T3S. This study reveals a previously unrecognized capacity of SIgA to "disarm" enteric pathogens in mucosal secretions, thereby preventing colonization and invasion of the intestinal epithelium.

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Proactive Procreation : Ethical Implications Of New Genetic Technologies For Parental Obligations To Future Offspring, L Syd M. Johnson Jan 2009

Proactive Procreation : Ethical Implications Of New Genetic Technologies For Parental Obligations To Future Offspring, L Syd M. Johnson

Legacy Theses & Dissertations (2009 - 2024)

This dissertation examines the ethical implications of recent genetic innovations, particularly preimplantation genetic diagnosis, for the obligations and duties of parents to future children. I critique common but uncompelling objections to the use of genetic information, diagnosis, and technology to influence the characteristics of future offspring, and conclude that genetic selection and enhancement are not different in kind or degree from other means of selection, direction, and enhancement that parents engage in to shape the lives of their children. Procreation is morally risky -- it risks imposing substantial burdens on persons who would not otherwise have to bear those burdens, …

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The Impact Of Environment On Virulence Of The Pathogenic Yeast Cryptococcus Gattii, Deborah Jean Springer Jan 2009

The Impact Of Environment On Virulence Of The Pathogenic Yeast Cryptococcus Gattii, Deborah Jean Springer

Legacy Theses & Dissertations (2009 - 2024)

Four serotypes of Cryptococcus are responsible for most human and animal infections. C. gattii , serotype B and C, are the primary the causative agent of cryptococcosis in immune competent individuals whilst, C. neoformans var. neoformans serotype D, and C. neoformans var. grubii serotype A are most prevalent in immunocompromised hosts world-wide. C. gattii is recognized as a species distinct from C. neoformans based on differences in clinical manifestations, morphology, biological characteristics, and environmental niche. We used the plant model Arabidopsis thaliana plants and plant derived substrates as a model to explore C. gattii interactions in its ecological niche. C. …

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Observations Of The Transient Characteristics Of The Hydrological Balance, Matthew Czikowsky Jan 2009

Observations Of The Transient Characteristics Of The Hydrological Balance, Matthew Czikowsky

Legacy Theses & Dissertations (2009 - 2024)

The impact of transient input events on the hydrological balance components are studied over a wide range of spatial and temporal scales. First, interception evaporation and energy-balance changes during and following precipitation events are examined at the site spatial and event temporal scale. Second, the hydrological response to spatial and seasonal changes in precipitation and evapotranspiration due to land cover changes are examined on the small-to-large watershed scale, covering the event to seasonal time scales.

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A Locus-Based Paradigm For Generating Systems Biological Inferences From Large Scale Functional Genomics Datasets, Ajish Dominic George Jan 2009

A Locus-Based Paradigm For Generating Systems Biological Inferences From Large Scale Functional Genomics Datasets, Ajish Dominic George

Legacy Theses & Dissertations (2009 - 2024)

Genomics data is growing at a exponential rate. The ability to integrate new results with existing knowledge about genomic biology is rapidly becoming the limiting factor as there no universal language with which to describe genomic functional elements. To integrate and compare new and existing genomic data, we define our basic functional unit of a genome to be a locus -- a set of positional coordinates along any genome with an arbitrary amount of functional annotations attached. The locus concept enables addressing genomic elements and annotations at any level of granularity from entire swaths of chromosomes to single base-positions. We …

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Raman Spectroscopy Of Body Fluids : A Nondestructive Identification Technique For Forensic Applications, Kelly Virkler Jan 2009

Raman Spectroscopy Of Body Fluids : A Nondestructive Identification Technique For Forensic Applications, Kelly Virkler

Legacy Theses & Dissertations (2009 - 2024)

The analysis of body fluid evidence during forensic investigations is a complicated process, yet it is a critical step in determining the key facts of a crime. There is no doubt that DNA analysis is an extremely useful tool that can identify a suspect or victim, but crime scene investigators must first locate and identify potential body fluid stains that can be collected for DNA analysis. Current screening tests are destructive to the sample and can give false positive results, so a nondestructive technique such as Raman spectroscopy, that can possibly confirm the presence of a particular fluid, could lend …

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Domestic Violence And Faith Communities : An Exploratory Study Examining Beliefs And Experiences Of Jews, Non-Jews, And Rabbis, Amanda Sisselman Jan 2009

Domestic Violence And Faith Communities : An Exploratory Study Examining Beliefs And Experiences Of Jews, Non-Jews, And Rabbis, Amanda Sisselman

Legacy Theses & Dissertations (2009 - 2024)

Purpose and Background: The current study examines the link between beliefs and experiences around domestic violence and religion, seeking to understand more about the ways in which Jews understand and experience domestic violence, while also looking to examine the context of these results in terms of religious comparison. The literature shows a preliminary connection between religion and domestic violence, in that victims have utilized their faith and faith communities as coping resources, but have also reported negative experiences within their religious communities. The literature only alludes to potential connections between beliefs regarding domestic violence and religion. Existing studies use mainly …

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Competitiveness And Addictive Behaviors : Exploring The Role Of Competitiveness And Gender In Exercise Dependence, Disordered Eating, And Alcohol Use, Holly Felicia Serrao Jan 2009

Competitiveness And Addictive Behaviors : Exploring The Role Of Competitiveness And Gender In Exercise Dependence, Disordered Eating, And Alcohol Use, Holly Felicia Serrao

Legacy Theses & Dissertations (2009 - 2024)

The current study explored whether or not trait competitiveness existed as an underlying factor contributing to the higher rates of exercise dependence, disordered eating, and alcohol use among athletes. Additionally, the study examined whether certain gender differences occurred, such that the relationship between competitiveness and disordered eating would be stronger for female athletes, the relationship between competitiveness and alcohol use would be stronger for male athletes, and the relationship between competitiveness and exercise dependence would be gender neutral.

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White Institutional Presence : The Impact Of Whiteness On Campus Climate & The Relational Context Of White Institutional Presence, Diane Lynn Gusa Jan 2009

White Institutional Presence : The Impact Of Whiteness On Campus Climate & The Relational Context Of White Institutional Presence, Diane Lynn Gusa

Legacy Theses & Dissertations (2009 - 2024)

This dissertation purports to offer a new lens on the retention puzzle of African-Americans in Predominately White Institutions. The purpose of this paper is to notice the properties of a PWI and analyzes the relational context these properties create for its African-American undergraduates. This dissertation is formatted into two sections. The first section frames, examines, and theorizes the "racism effect" in higher education - the "ways in which race and racism explicitly and implicitly impact on the educational structures, processes, and discourses that affect people of color" (LatCrit Primer, 2000, p. xx). I maintain that African-Americans' experiences of marginalization and …

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Family Literacy And Digital Literacies : A Redefined Approach To Examining Social Practices Of An African-American Family, Tisha Yvette Lewis Jan 2009

Family Literacy And Digital Literacies : A Redefined Approach To Examining Social Practices Of An African-American Family, Tisha Yvette Lewis

Legacy Theses & Dissertations (2009 - 2024)

Abstract

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A Study Of Cantilever-Free Instrumentation For Nanoscale Magnetic Measurements, Bruce Adair Altemus Jan 2009

A Study Of Cantilever-Free Instrumentation For Nanoscale Magnetic Measurements, Bruce Adair Altemus

Legacy Theses & Dissertations (2009 - 2024)

The evolution of the Atomic Force Microscope (AFM) into the Magnetic Force Microscope (MFM) and Magnetic Resonance Force Microscope (MRFM) has had a substantial impact on the characterization of nanoscale phenomena. Detection of 10-17 Newtons per root Hertz has occurred with use of an ultra-sensitive cantilever along with optical interferometry methods within these geometries. The sensitivity of these platforms is dependent on the characteristics of the cantilever, where increased length and a low Young's modulus increase the force sensitivity (meters/Newtons). Using IC fabrication techniques, the realization of generating cantilevers with this sensitivity is feasible, but stress compensation layers are required …

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Infected Justice : The Impact Of Hiv/Aids On The Police In Anglo-Phone Sub-Saharan Africa, Nathan Carl Meehan Jan 2009

Infected Justice : The Impact Of Hiv/Aids On The Police In Anglo-Phone Sub-Saharan Africa, Nathan Carl Meehan

Legacy Theses & Dissertations (2009 - 2024)

Sub-Saharan Africa is an epicenter of the HIV/AIDS epidemic. This disease is affecting nearly every aspect of society in this region. This disease destroys individuals, strains family structures, weakens economies, burdens health systems, and can destabilize entire countries. The police are also being affected by HIV/AIDS. The way in which this disease impacts police organizations in sub-Saharan Africa is understudied. This project sought to estimate the HIV/AIDS impacts on police organizations in Anglo-phone sub-Sahara by utilizing the available literature on how HIV/AIDS affects military, civil service, healthcare, and education organizations in these same countries. It also attempts to identify the …

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Continuous Glucose Monitoring Microsensor With A Nanoscale Conducting Matrix And Redox Mediator, Daniel Pesantez Jan 2009

Continuous Glucose Monitoring Microsensor With A Nanoscale Conducting Matrix And Redox Mediator, Daniel Pesantez

Legacy Theses & Dissertations (2009 - 2024)

The major limiting factor in kidney clinical transplantation is the shortage of transplantable organs. The current inability to distinguish viability from non-viability on a prospective basis represents a major obstacle in any attempt to expand organ donor criteria. Consequently, a way to measure and monitor a relevant analyte to assess kidney viability is needed. For the first time, the initial development and characterization of a metabolic microsensor to assess kidney viability is presented. The rate of glucose consumption appears to serve as an indicator of kidney metabolism that may distinguish reversible from irreversible kidney damage. The proposed MetaSense (Metabolic Sensor) …

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Harm Reduction In Outpatient Drug-Free Substance Abuse Treatment Settings, Michael Eversman Jan 2009

Harm Reduction In Outpatient Drug-Free Substance Abuse Treatment Settings, Michael Eversman

Legacy Theses & Dissertations (2009 - 2024)

In the United States, drug-free substance abuse treatment programs generally operate under an abstinence-only, disease model based service orientation. Citing several reasons, critics suggest disease model approaches hinder client utilization and retention within such services. The framework of harm reduction offers an alternative approach to substance abuse treatment services and may have potential for improving utilization and retention outcomes. Yet little is known about how harm reduction is perceived by practitioners in drug-free substance abuse treatment settings, and the circumstances in which harm reduction may or may not be accepted. In addition, despite a body of narrative literature suggesting harm …

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Opportunism And Diversity In The Lifestyle Of A Group Ii Intron, Arthur R. Beauregard Jan 2009

Opportunism And Diversity In The Lifestyle Of A Group Ii Intron, Arthur R. Beauregard

Legacy Theses & Dissertations (2009 - 2024)

Group II introns are mobile retroelements. They invade the cognate intron-minus gene in an efficient process known as retrohoming. They can also retrotranspose to ectopic sites at low frequency. Retrohoming occurs by the intron RNA reverse-splicing into double-stranded DNA (dsDNA) through an endonuclease-dependent pathway. However, in retrotransposition in Lactoccocus lactis, the intron inserts predominantly into single-stranded DNA (ssDNA), in an endonuclease-independent manner. Unlike in L. lactis, in Escherichia coli the Ll.LtrB intron retrotransposes frequently into dsDNA, and the process is dependent on the endonuclease activity of the intron-encoded protein. Further, the endonuclease-dependent integrations preferentially occurred around the origin and terminus …

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The Assessment Of Associations Between Organochlorine Pollutants And Hypertension And Blood Pressure Among Anniston (Alabama) Residents, Alexey Borislavovich Goncharov Jan 2009

The Assessment Of Associations Between Organochlorine Pollutants And Hypertension And Blood Pressure Among Anniston (Alabama) Residents, Alexey Borislavovich Goncharov

Legacy Theses & Dissertations (2009 - 2024)

Hypertension is recognized as one of the serious chronic diseases of humankind and as a major risk factor for death from heart attack and stroke. The cause of essential hypertension is poorly understood. We have investigated the relationship of polychlorinated biphenyls (PCB) and organochlorine pesticide exposure with hypertension and blood pressure in organochlorines exposed residents of Anniston, Alabama.

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Role Of Cyp2a5 In Drug Metabolism, Chemical Toxicity, And Maintenance Of Steroid Hormone Homeostasis : Insights From Studies On A Novel Cyp2a5-Null Mouse Model, Xin Zhou Jan 2009

Role Of Cyp2a5 In Drug Metabolism, Chemical Toxicity, And Maintenance Of Steroid Hormone Homeostasis : Insights From Studies On A Novel Cyp2a5-Null Mouse Model, Xin Zhou

Legacy Theses & Dissertations (2009 - 2024)

The central hypothesis is that CYP2A5 plays an important role in the metabolism of xenobiotic substrates, and in the toxicity induced by over-exposure to drugs, as well as in the metabolism of endogenous compounds and regulation of steroid hormone homeostasis. The specific aims are: 1) to generate and characterize a Cyp2a5-null mouse; 2) to determine the role of CYP2A5 in the systemic clearance of nicotine and cotinine; and 3) to explore the mechanisms underlying the resistance of the lateral nasal gland (LNG) of male Cyp2g1-null/Cyp2a5-low mouse and Cyp2a5-null mouse to acetaminophen (AP) toxicity.

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The Relevance Of The Supervisory Working Alliance To Burnout And Vigor Among Residential Frontline Staff, Laura M. Deihl Jan 2009

The Relevance Of The Supervisory Working Alliance To Burnout And Vigor Among Residential Frontline Staff, Laura M. Deihl

Legacy Theses & Dissertations (2009 - 2024)

The study tested hypotheses about (a) the perceived balance of personal resources experienced by residential frontline staff (RFS) to meet the challenges and demands at work and (b) the relevance of the supervisory relationship to support their job-specific wellbeing. Consistent with the Conservation with Resources (COR, Hobfoll, 1989, 1998; Hobfoll & Freedy, 1993; Hobfoll & Shirom, 2001) theory, burnout and vigor were measured by the RFS's reported levels of available personal energy resources.

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Identification Of B-Cell Epitopes On Domain 4 Of Anthrax Protective Antigen, Cassandra D. Kelly-Cirino Jan 2009

Identification Of B-Cell Epitopes On Domain 4 Of Anthrax Protective Antigen, Cassandra D. Kelly-Cirino

Legacy Theses & Dissertations (2009 - 2024)

Protective Antigen (PA) is the receptor binding subunit common to both Lethal (LT) and Edema (ET) toxins, which contribute to the mortality associated with Bacillus anthracis infection. While recombinant PA (rPA) is likely to be an important constituent of second generation anthrax vaccines, evaluating the effectiveness of candidate vaccines is currently difficult, because the specific B cell epitopes involved in toxin neutralization have not been completely defined. The only well characterized antibody, 14B7, has been shown to disrupt the association of PA with the anthrax toxin receptors (ATR) by binding to domain 4 of PA. I hypothesized that other domain …

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Biomonitoring Of Perfluorochemicals In Human Blood, Breast Milk, Saliva, And Urine, Lin Tao Jan 2009

Biomonitoring Of Perfluorochemicals In Human Blood, Breast Milk, Saliva, And Urine, Lin Tao

Legacy Theses & Dissertations (2009 - 2024)

Perfluorochemicals (PFCs) have been used as surfactants and surface protectors in a large number of consumer products. PFCs have been reported to elicit adverse health effects in laboratory animals and humans, and have been detected in foodstuffs and in human bodies. In this dissertation, analytical methods were developed for the determination of trace levels of PFCs in human blood, dried blood spot, breast milk, saliva, and urine. An assessment of human exposure to PFCs was performed by analyzing human specimens collected from the United States and several Asian countries. Blood, breast milk, and dried blood spots were found to be …

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Toward A New Mystical Poetics Of God In The Post-Mortem Age : From God As The Supreme Being To God As The One-And-Only Being, John Francis O'Neill Jan 2009

Toward A New Mystical Poetics Of God In The Post-Mortem Age : From God As The Supreme Being To God As The One-And-Only Being, John Francis O'Neill

Legacy Theses & Dissertations (2009 - 2024)

At certain axial moments in history new religious worldviews emerge to replace prior perspectives that are no longer adequate or persuasive. A new worldview opens new possibilities for the human religious quest for meaning, being, and salvation. A fundamental conviction underlying this dissertation is that we are living in a "post-mortem age" - that is, an era defined by profound challenges to the centuries-long dominant religious worldview, culminating in the twentieth century experience of the "death of God." While disturbing and disruptive for many, this historical condition can also be seen as a liberating and even providential event, opening the …

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The Representation Of Multiple Translations In Bilingual Memory : An Examination Of Lexical Organization For Concrete, Abstract, And Emotion Words In Spanish-English Bilinguals, Dana M. Basnight-Brown Jan 2009

The Representation Of Multiple Translations In Bilingual Memory : An Examination Of Lexical Organization For Concrete, Abstract, And Emotion Words In Spanish-English Bilinguals, Dana M. Basnight-Brown

Legacy Theses & Dissertations (2009 - 2024)

Tokowicz and Kroll (2007) originally reported that the number of translations a word has across languages influences the speed with which bilinguals translate concrete and abstract words from one language to another. The current work examines how the number of translations that characterize a word influences bilingual lexical organization and the processing of concrete, abstract and emotional stimuli. Experiment 1 examined whether the number-of-translations effect reported previously could be obtained in a different task (i.e., lexical decision task) using the same materials presented by Tokowicz and Kroll. Decision latencies revealed no significant differences between concrete and abstract words, which suggested …

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Observer Effects Of Non-Sexual Nipple Erection And Their Possible Reproductive Advantages In Human Females, Amy J. Lefevre Jan 2009

Observer Effects Of Non-Sexual Nipple Erection And Their Possible Reproductive Advantages In Human Females, Amy J. Lefevre

Legacy Theses & Dissertations (2009 - 2024)

Nipple erection in women for any purpose other than lactation is somewhat of an evolutionary mystery. In earlier studies I found evidence of nonsexual nipple erection (NSNE) in females in response to anxiety-provoking stimulus material (LeFevre, unpublished). The goal of the present research was to determine what benefits, if any, that NSNE may confer upon females who display this behavior. Specifically, two studies tested the general proposition that non-sexual nipple erection decreases aggressiveness in males and looked at the possibility that cognitive interference may be a mediating factor in aggression de-escalation. Fifty-one undergraduate students (33 male and 18 female) took …

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Multifrequency Epr Studies On Vanadyl And Nitroxide Complexes Via Bayesian Inference, Relativistic Density Functional Theory, And Lineshape Analysis, Indra Dev Sahu Jan 2009

Multifrequency Epr Studies On Vanadyl And Nitroxide Complexes Via Bayesian Inference, Relativistic Density Functional Theory, And Lineshape Analysis, Indra Dev Sahu

Legacy Theses & Dissertations (2009 - 2024)

This present work consists of multifrequency Electron Paramagnetic Resonance (EPR) studies of the model compounds by performing EPR experiments on Vanadyl acetylacetonate [VO(acac)2] and Vanadyl meso-tetraphenylporphin [VO(TPP)] at different frequencies (3GHz, 9.9GHz, 23.8GHz, 34GHz and 95GHz) in motional narrowing regime and at 9.9 GHz in rigid limit regime. Additional experiments were performed on PD-Tempone (Perdeuterated 2, 2, 6, 6-Tetramethyl-4-piperidone N-Oxide) spin labels in Cyclodextrins and glycerol/water mixtures at 9.3GHz from the rigid limit to the motional narrowing regime.

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Interoceptive Fear Conditioning And Panic Disorder Ii : Clarifying The Role Of Cs-Us Discrimination, Dean Thomas Acheson Jan 2009

Interoceptive Fear Conditioning And Panic Disorder Ii : Clarifying The Role Of Cs-Us Discrimination, Dean Thomas Acheson

Legacy Theses & Dissertations (2009 - 2024)

Despite the role afforded interoceptive fear conditioning in learning theory accounts of panic disorder, there exists little research demonstrating such learning in humans. A recent study by Acheson and colleagues (2007) was the first to successfully demonstrate interoceptive fear conditioning in humans. The authors employed a single-cue fear learning paradigm with 20% carbon dioxide-enriched air as interoceptive conditioned (CS) and unconditioned (US) stimuli. The current study had two aims: 1) to replicate the results of Acheson et al. (2007) while improving upon the methodology, and 2) to clarify the role of CS - US discrimination in fear learning and extinction. …

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Work-Family Conflict And Psychological Distress In U.S. Latino Mothers And Fathers : The Moderating Effects Of Familismo And Gender, Ingrid Vanessa Rodriguez Jan 2009

Work-Family Conflict And Psychological Distress In U.S. Latino Mothers And Fathers : The Moderating Effects Of Familismo And Gender, Ingrid Vanessa Rodriguez

Legacy Theses & Dissertations (2009 - 2024)

Conflicts between work and family domains have been found to negatively affect physical and psychological wellbeing. In studies with European Americans, the relationship between work-family conflict and psychological distress appears to be comparable across gender; however, research with Latinos has found that women experienced significantly more work-family conflict than men. The majority of the work-family literature has focused on work variables that contribute to or reduce work-family conflict and distress; thus, the beneficial aspects of family have been largely ignored. There is some evidence to suggest that a supportive family life could have positive effects on the work domain, thereby …

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An Rnai Screen Targeting The Protein Tyrosine Kinases Identifies Bruton's Tyrosine Kinase (Btk) As A Breast Cancer Cell Survival Factor, Cheryl Lynne Eifert Jan 2009

An Rnai Screen Targeting The Protein Tyrosine Kinases Identifies Bruton's Tyrosine Kinase (Btk) As A Breast Cancer Cell Survival Factor, Cheryl Lynne Eifert

Legacy Theses & Dissertations (2009 - 2024)

The receptor protein tyrosine kinases (RPTKs) and the non- receptor protein tyrosine kinases (PTKs) are among the most commonly up-regulated genes found in all types of cancers. Although, a large body of data implicates a majority of tyrosine kinases (TKs) in cancer, few have been extensively evaluated for any potential therapeutic benefit in any of the many subtypes of breast cancer. We have used RNA interference (RNAi) to perform a large-scale loss-of-function analysis to facilitate the identification of individual factors necessary for the survival of an ErbB2 positive breast cancer cell line. We have found that 30% of the TKs …

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