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2009

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Genetic And Non-Genetic Factors That Cause Inter-Individual Variations In Cyp2a13 Gene Expression, Hong Wu Jan 2009

Genetic And Non-Genetic Factors That Cause Inter-Individual Variations In Cyp2a13 Gene Expression, Hong Wu

Legacy Theses & Dissertations (2009 - 2024)

The overall goal of this dissertation is to investigate the mechanisms underlying the large interindividual variations in susceptibility to lung carcinogenesis. We focused on CYP2A13, a respiratory tract-specifically expressed enzyme, which is the most efficient P450 towards bioactivation of a tobacco-related carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). The expression level of CYP2A13 varies substantially among human lung samples. Our central hypothesis is that CYP2A13 expression level is affected by both genetic regulators and non-genetic factors. The specific aims are 1) to identify the mechanisms underlying the decreased allelic expression of a CYP2A13 allele (7520C>G); 2) to identify frequent single-nucleotide polymorphisms (SNPs), associated …

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Critical Mass Or Critical Acts? : An Empirical Test Of The Relationship Between The Presence Of Women In State Legislatures And Their Policy Impact On Agenda Setting And Legislative Success In Fifty Sates, 1995 And 2005, Angela Chen Dalton Jan 2009

Critical Mass Or Critical Acts? : An Empirical Test Of The Relationship Between The Presence Of Women In State Legislatures And Their Policy Impact On Agenda Setting And Legislative Success In Fifty Sates, 1995 And 2005, Angela Chen Dalton

Legacy Theses & Dissertations (2009 - 2024)

Research on gender and politics often invokes Kanter's (1977) critical mass theory to draw a linkage between women political leaders' descriptive representation and substantive representation. Using the 50 state legislatures as the unit of analysis, I empirically tested the validity of the critical mass theory by investigating the relationship between women's share of legislative seats within lower chambers of state houses and their impact on legislative agenda setting and legislative success in 1995 and 2005. Based on the findings, I argue that the critical mass theory is of limited value in explaining women's policy impact and the field of gender …

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Genetically Engineered Repetitive Polypeptides : Design, Synthesis, Characterization, And Applications, Natalya I. Topilina Jan 2009

Genetically Engineered Repetitive Polypeptides : Design, Synthesis, Characterization, And Applications, Natalya I. Topilina

Legacy Theses & Dissertations (2009 - 2024)

This work is dedicated to the investigation of protein folding with the emphasis on the aggregation and amyloid fibrils formation. The focus of the research is to elucidate the relationship between polypeptide chain sequence and folding/aggregation properties. For this purpose, i) libraries of the de novo macromolecular repetitive β-sheet forming polypeptides were designed, and ii) the strategy for their rapid creation was developed. The strategy enables retention of a basic polypeptide core, yet allowing variations in the repetitive sequence, degree of polymerization and distribution of specific amino acids. The polypeptides were expressed in E. coli, purified, and characterized by various …

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Secondary Structures And Thermodynamic Properties Of Ampa Receptor Aptamers, Sabarinath Jayaseelan Jan 2009

Secondary Structures And Thermodynamic Properties Of Ampa Receptor Aptamers, Sabarinath Jayaseelan

Legacy Theses & Dissertations (2009 - 2024)

Using systematic evolution of ligands by exponential enrichment (SELEX), our lab previously selected a class of competitive RNA aptamers against the alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. One aptamer in this class was found to have a minimal, functional sequence of 58 nucleotides. In vitro transcription generates two RNA transcripts with the same sequence, which we named M1 and M2, both of which are required to work together to inhibit the AMPA receptors. Although the M1 and M2 species have the same sequence, they cannot be interconverted through unfolding by denaturation/refolding by renaturation. To probe the secondary structures and the thermodynamic …

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Bootstrapping Events And Relations From Text, Ting Liu Jan 2009

Bootstrapping Events And Relations From Text, Ting Liu

Legacy Theses & Dissertations (2009 - 2024)

Information Extraction (IE) is a technique for automatically extracting structured data from text documents. One of the key analytical tasks is extraction of important and relevant information from textual sources. While information is plentiful and readily available, from the Internet, news services, media, etc., extracting the critical nuggets that matter to business or to national security is a cognitively demanding and time consuming task. Intelligence and business analysts spend many hours poring over endless streams of text documents pulling out reference to entities of interest (people, locations, organizations) as well as their relationships as reported in text. Such extracted "information …

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The Influence Of Perceived Origins Of Learning Difficulties And Professional Role On The Acceptability Of The Iq-Achievement Discrepancy And Response-To-Intervention (Rti) Approaches To Learning Disability Classification, Matthew Amore Raso Jan 2009

The Influence Of Perceived Origins Of Learning Difficulties And Professional Role On The Acceptability Of The Iq-Achievement Discrepancy And Response-To-Intervention (Rti) Approaches To Learning Disability Classification, Matthew Amore Raso

Legacy Theses & Dissertations (2009 - 2024)

The present study assessed the acceptability of both the IQ-achievement discrepancy approach and the Response-to-Intervention (RTI) approach to LD classification among teachers, school psychologists, and school administrators. Relationships between each of these variables and perceived origins of learning difficulties among these professionals were also assessed. RTI received more favorable acceptability ratings when compared with the IQ-achievement approach, and more weight was attributed to instructional influences than either biological or environmental influences across all three groups, although significant between-group differences were noted. Biologically and instructionally-based explanations of learning difficulties were significant predictors of IQ-achievement acceptability, but in opposite directions. In contrast, …

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Multifrequency Epr Studies On Copper And Nitroxide Complexes Via Bayesian Inference, Density Functional Theory And Lineshape Analysis, Laxman Mainali Jan 2009

Multifrequency Epr Studies On Copper And Nitroxide Complexes Via Bayesian Inference, Density Functional Theory And Lineshape Analysis, Laxman Mainali

Legacy Theses & Dissertations (2009 - 2024)

The work reported in this thesis uses Bayesian inference and density functional theory (DFT) to perform multifrequency Electron Paramagnetic Resonance (EPR) lineshape analysis on copper and nitroxide complexes.

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Glossolalia Influences On Stress Response Among Apostolic Pentecostals, Christopher Dana Lynn Jan 2009

Glossolalia Influences On Stress Response Among Apostolic Pentecostals, Christopher Dana Lynn

Legacy Theses & Dissertations (2009 - 2024)

This study tests the hypothesis that long–term experience of Apostolic Pentecostal glossolalia or “speaking in tongues” reduces the reactivity of biological stress response to normal or "daily" stressors. Glossolalia is a form of religious dissociation. Dissociation is a universal capacity often conflated with “trance.” It refers to the partitioning of awareness associated with a variety of cross–cultural forms, from daydreaming and denial to possession trance, shamanic spirit journeys, and dissociative identity disorder. Dissociation is believed to reduce or filter stress by mediating evaluation of potential stressors and reactivity of the mechanisms of biological stress response. Previous studies have examined these …

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Mercury Uptake By Aquatic Macrophytes In Urban And Rural Watersheds, Albany County, Ny, Bernd G. Neumann Jan 2009

Mercury Uptake By Aquatic Macrophytes In Urban And Rural Watersheds, Albany County, Ny, Bernd G. Neumann

Geology Theses and Dissertations

Plants growing in metalliferous soils may restrict metal uptake and transport depending on metal concentration, sediment characteristics, and plant species. As native plants are replaced by invasives, different patterns of metal cycling can occur, making continued study of this process important. Sediments and tissues of four aquatic plant species/genera: Phragmites australis (common reed); Iris versicolor (blueflag iris); Typha latifolia (broadleaf cattail); and genera Cyperus sp. (sedge) from three urban and two rural sites in Albany County, NY were analyzed for total mercury (Hg­T) by cold vapor atomic absorption spectroscopy. Sediments were also measured for organic carbon (OC) by …

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The Effect Of Vegetated Roofs On Acid Precipitation Runoff, Jennifer Gillen Jan 2009

The Effect Of Vegetated Roofs On Acid Precipitation Runoff, Jennifer Gillen

Geology Theses and Dissertations

Vegetated, or “green” roofs are used in urban architecture and sustainable building to capture stormwater and enhance urban wildlife. Most research to date has focused on their water retention capabilities, but green roofs also have the potential to treat anthropogenic acid precipitation in urban environments. More specifically, green roofs could reduce sulfate, nitrate and hydrogen ion concentrations in runoff. One previous study has demonstrated that nitrate was reduced in water draining from a green roof (Berndtsson, et al. 2006), but this unpublished thesis appears to be the first comprehensive study of the effects of vegetated roof materials on major ions …

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The Weekly Challenger, January 1, 2009, The Weekly Challenger, Et Al Jan 2009

The Weekly Challenger, January 1, 2009, The Weekly Challenger, Et Al

Weekly Challenger Newspaper Collection

The January 1, 2009, issue of The Weekly Challenger.

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Alaskan Caver, Volume 29, No. 1, January 2009, Carlene Allred Jan 2009

Alaskan Caver, Volume 29, No. 1, January 2009, Carlene Allred

Alaskan Caver

Contents: Nizina Cave Hunt and Alder Thrash, by Steve Lewis - Map of Latticework Chamber - Map of Three Sherp No Skunk Cave - Map of Cracked Up Cave - Mendenhall Glacier Caves Hike, by Jansen Cardy - Contract Cave, by Gwen Herrewig - Grotto Website - President's Corner - Letter - Nizina Glacier Passage, by Jean Krejca

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Measurement Of Atmospheric Ammonia Species : Development, Validation, And Field Applications Of An Analytical Method, Jian Hou Jan 2009

Measurement Of Atmospheric Ammonia Species : Development, Validation, And Field Applications Of An Analytical Method, Jian Hou

Legacy Theses & Dissertations (2009 - 2024)

Ammonia is the primary base in the atmosphere. It reacts readily with atmospheric acids such as sulfuric acid, nitric acid, and hydrochloric acid to form ammonium salts that occur predominantly in the fine aerosol particle (PM2.5) fraction. The ability to measure ammonia species (NHx, the sum of gaseous NH3 and particulate NH4+) is essential for the investigation of atmospheric behaviors of NHx. In this dissertation work, a highly sensitive technique has been developed for the measurement of atmospheric NHx species. The method is based on aqueous scrubbing of the atmospheric NH3 and NH4+ using …

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The Recognition And Folding Of Ncp7 (Nucleocapsid Protein) With Tardna And Psi Site Rna Hairpin Structures From Hiv-1 : A Spin Label Study, Yan Sun Jan 2009

The Recognition And Folding Of Ncp7 (Nucleocapsid Protein) With Tardna And Psi Site Rna Hairpin Structures From Hiv-1 : A Spin Label Study, Yan Sun

Legacy Theses & Dissertations (2009 - 2024)

The nucleocapsid (NC) protein NCp7 of the human immunodeficiency virus type 1(HIV 1) is a small basic protein with two zinc finger motifs. NCp7 has key roles in virus replication and structure, which rely on its interactions with nucleic acids. We investigated the interaction of NCp7 with Transactivation Response Element (TAR) DNA which is critical for minus strand transfer during the HIV 1 reverse transcription. The EPR spin probe nitroxide was used as the reporter. Binding of NCp7 to TARDNA caused TARDNA condensation, as inferred from the probe tumbling time which markedly increased to several nanoseconds at a 4:1 NCp7 …

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Molecular Evolution Of Genes Underlying Phenotypic Differences Between Humans And Chimpanzees, Santhoshi Bandla Jan 2009

Molecular Evolution Of Genes Underlying Phenotypic Differences Between Humans And Chimpanzees, Santhoshi Bandla

Legacy Theses & Dissertations (2009 - 2024)

Chimpanzees (Pan troglodytes) and bonobos (P. paniscus) are often used as models to study the genetic and morphological changes on the lineage leading to the modern humans (Homo sapiens). Results of this dissertation suggest that, in comparison to other hominoids, chimpanzees and bonobos are more derived in their relative testes sizes and promiscuous mating systems. Phylogenetic analysis of genes that might underlie increased testes size revealed that, in addition to being a sex-determining gene, SRY displays Pan-specific amino acid replacements that make it a compelling candidate as a testes-size determining gene. Strikingly, SRY and another candidate gene, DMRT3, display patterns …

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Biomonitoring For Exposure To Trace Elements In Utero : Analysis Of The Human Placenta, Pamela Catherine Kruger Jan 2009

Biomonitoring For Exposure To Trace Elements In Utero : Analysis Of The Human Placenta, Pamela Catherine Kruger

Legacy Theses & Dissertations (2009 - 2024)

The placenta forms in eutherian mammals, and is responsible for the nutrition of the developing fetus. However, maternal exposure to environmental pollutants both before and during pregnancy may result in the passage of toxins through the placental barrier and into fetal tissues. The placenta is the only organ derived from both maternal and fetal tissues, and establishes a link between the fetus and the environmental exposures of the mother. The analysis of placentae for the presence of environmental pollutants offers the possibility of exposure measurements in both the mother and the developing fetus. Specifically, trace element determination in human placentae …

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Impulsivity, Offending, And The Neighborhood : Investigating The Person-Context Nexus, Gregory M. Zimmerman Jan 2009

Impulsivity, Offending, And The Neighborhood : Investigating The Person-Context Nexus, Gregory M. Zimmerman

Legacy Theses & Dissertations (2009 - 2024)

A key assumption of the traditional trait-based approach to the study of crime is that personality traits cause people to act similarly across a wide array of contexts. This approach has been challenged for its failure to acknowledge differences in the social environments to which individuals are exposed. Similarly, community-level explanations of crime have been criticized for failing to acknowledge that there are important individual differences between criminals and non-criminals. Ultimately, a full understanding of crime requires the consideration of both individual and environmental differences, perhaps most importantly because they may interact to produce offending behavior. In particular, the influence …

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Three-Dimensional Hydrogel Cell Culture Systems For Modeling Neural Tissue, John P. Frampton Jan 2009

Three-Dimensional Hydrogel Cell Culture Systems For Modeling Neural Tissue, John P. Frampton

Legacy Theses & Dissertations (2009 - 2024)

Two-dimensional (2-D) neural cell culture systems have served as physiological models for understanding the cellular and molecular events that underlie responses to physical and chemical stimuli, control sensory and motor function, and lead to the development of neurological diseases. However, the development of three-dimensional (3-D) cell culture systems will be essential for the advancement of experimental research in a variety of fields including tissue engineering, chemical transport and delivery, cell growth, and cell-cell communication. In 3-D cell culture, cells are provided with an environment similar to tissue, in which they are surrounded on all sides by other cells, structural molecules …

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Self-Esteem, Self-Compassion, Defensive Self-Esteem, And Related Features Of Narcissism As Predictors Of Aggression, Cara Pharr Gottheim Jan 2009

Self-Esteem, Self-Compassion, Defensive Self-Esteem, And Related Features Of Narcissism As Predictors Of Aggression, Cara Pharr Gottheim

Legacy Theses & Dissertations (2009 - 2024)

This study sought to expand upon existing literature pertaining to feelings toward oneself and aggressive behavior. Specifically, global self-esteem, as well as two specific subsets of self-esteem, defensive self-esteem and narcissistic self-esteem, were examined as predictors of aggressive behavior. Additionally, the relationship between aggression and self-compassion, a recently introduced self-construct moderately correlated with self-esteem, was investigated. College students from a large Northeastern University were invited via email or through a brief classroom presentation to participate in this online study. A total of 181 students completed five surveys that were useable for data analyses: Rosenberg Self-Esteem Scale (SES; Rosenberg, 1989), Self-compassion …

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Biotechnology For Immune Cell Detection And Evaluation : Devices Specifically Designed To Capture, Detect Or To Evaluate Alterations In Leukocyte Structure And Function, Thomas Joseph Zieziulewicz Jan 2009

Biotechnology For Immune Cell Detection And Evaluation : Devices Specifically Designed To Capture, Detect Or To Evaluate Alterations In Leukocyte Structure And Function, Thomas Joseph Zieziulewicz

Legacy Theses & Dissertations (2009 - 2024)

The advent of Nano-biotechnology has opened a whole new area of biological study that has allowed us to pattern, manipulate, separate, evaluate and detect biological structures and functions that were previously not possible. This dissertation will describe different types of micro-fabricated devices that were designed to quantify and/or evaluate the functional activities of cells of the immune system. The micro-fabricated devices were developed in collaboration with our colleagues at Princeton University as part of our Cellular Micro-dynamics Program of the Nanobiotechnology Center (NBTC) at Cornell University.

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Pathways To Obesity In Women : The Role Of Coping And Emotional Eating, Veronica Nicole Stotts Jan 2009

Pathways To Obesity In Women : The Role Of Coping And Emotional Eating, Veronica Nicole Stotts

Legacy Theses & Dissertations (2009 - 2024)

Obesity is a major health crisis in the United States, with approximately two-thirds of the population qualifying as overweight and, of those, almost one half qualifying as obese (CDC, 2007). While there are a myriad of causes of obesity, a great deal of evidence shows that many individuals, and particularly women, eat as a coping response to stress (e.g., Greeno & Wing, 1994). Therefore, one's ability to cope, or the process by which individuals deal with situations that involve stress or threat, may be a factor that contributes to increased body mass index, or BMI, a common measure of obesity. …

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A Descriptive Analysis Of The Problems And Interventions Observed In Care Planning For Nursing Home Residents With Dementia, Dennis Gordon Chapman Jan 2009

A Descriptive Analysis Of The Problems And Interventions Observed In Care Planning For Nursing Home Residents With Dementia, Dennis Gordon Chapman

Legacy Theses & Dissertations (2009 - 2024)

Abstract

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Study Of Dynamic Processes In Protein Synthesis Using Heterogeneous Ribosome Specimens, Jie Fu Jan 2009

Study Of Dynamic Processes In Protein Synthesis Using Heterogeneous Ribosome Specimens, Jie Fu

Legacy Theses & Dissertations (2009 - 2024)

Single-particle reconstruction from cryo-electron microscopy (cryo-EM) images is a widely used technique in studying the structure of macromolecular complexes. This technique allows the visualization of molecules in their native hydrated state. The heterogeneity of two-dimensional projection images, resulting from the co-existence of different states of a macromolecular complex, remains a major obstacle, as it impairs the validity of reconstruction and limits the progress toward higher resolution. On the other hand, co-existing structures, if successfully extracted from a single dataset, can provide valuable information about the equilibrium and dynamics of the biological system being studied.

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Synthesis And Evaluation Of Some Steroidal Oximes As Cytotoxic Agents: Structure/Activity Studies (I), Jianguo Cui, Lei Fan, Li Liang Huang, Hong Li Liu, Aimin Zhou Jan 2009

Synthesis And Evaluation Of Some Steroidal Oximes As Cytotoxic Agents: Structure/Activity Studies (I), Jianguo Cui, Lei Fan, Li Liang Huang, Hong Li Liu, Aimin Zhou

Chemistry Faculty Publications

The side chain of a compound plays an important role in its biological function. In our studies, we have found that hydroximinosteroid derivatives with different side chains and position of hydroximino on ring A and B displayed remarkable distinct cytotoxicities against a diversity of cancer cell types. Presence of an oxime group on ring B and a hydroxy on ring A or B resulted in a higher cytotoxicity than other structural motifs. In addition, a cholesterol-type side chain at position 17 was required for the biological activity. Our findings provide new evidence showing the relationship between the chemical structure and …

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Passages, Volume 10, No. 2, Summer 2009, Joe Mitchell Jan 2009

Passages, Volume 10, No. 2, Summer 2009, Joe Mitchell

Texas Cave Management Association

Contents: TCMA: Cavers Protecting Caves -- View from the Palit -- Deep & Punkin Caves: Two Texas Classics -- TCMA -- Ezell's Cave: Home of the Blind Monster -- Godwin Ranch: Habitat for Endangered Species -- Rolling Oaks: A Small Preserve Protecting Small Creatures -- Robber Baron: History, Mystery, and Restoration -- Deep and Punkin Cave Survey Update -- LIDAR Mapping the Devil's Sinkhole -- Linda Palit: Highlights from a Lifetime of Caving -- LIDAR -- A Geology Field Trip to Deep & Punkin Caves -- RBC -- Whirlpool Preserve -- Lost Oasis Preserve -- TCMA Supports the 15th ICS …

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Same-Sex Parenting : Bringing Awareness To The Challenges And Strengths Of Gay And Lesbian Parents Today, Maria Fernanda Sanchez Jan 2009

Same-Sex Parenting : Bringing Awareness To The Challenges And Strengths Of Gay And Lesbian Parents Today, Maria Fernanda Sanchez

Honors Capstones

This paper’s objective was to bring awareness as well as understanding to same-sex parents. The challenges as well as strengths and resilience factors of same-sex parents were examined through a review of the existing literature on the topic. The main points of the paper included the diversity of gay and lesbian families, common misconceptions about them, the legal challenges they face, as well as other obstacles they may encounter. The way these families cope with their problems as well as considerations for therapists working with them were also discussed. The main conclusion of the paper is that there are no …

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For 275.01: Wildlife Conservation, Mark Hebblewhite Jan 2009

For 275.01: Wildlife Conservation, Mark Hebblewhite

University of Montana Course Syllabi

No abstract provided.

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Rscn 273.01: Wilderness And Civilization - Field Studies, Nicky Phear, Paul Alaback Jan 2009

Rscn 273.01: Wilderness And Civilization - Field Studies, Nicky Phear, Paul Alaback

University of Montana Course Syllabi

No abstract provided.

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Rscn 273.01: Wilderness And Civilization I - Field Studies, Nicky Phear Jan 2009

Rscn 273.01: Wilderness And Civilization I - Field Studies, Nicky Phear

University of Montana Course Syllabi

No abstract provided.

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Spring Commencement, April 26, 2009, Eastern Michigan University Jan 2009

Spring Commencement, April 26, 2009, Eastern Michigan University

Commencement Programs and Materials

No abstract provided.

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