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2009

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Patents & (And) The Progress Of Personalized Medicine: Biomarkers Research As Lens, Matthew Herder Jan 2009

Patents & (And) The Progress Of Personalized Medicine: Biomarkers Research As Lens, Matthew Herder

Annals of Health Law and Life Sciences

This article addresses the barriers to personalized medicine, focusing on the burgeoning field of biomarkers research. The author begins by framing intellectual property issues as more than a product of industry incentives and suggests that these issues are deeply entangled with other barriers facing personalized medicine such as regulatory framework deficiencies. The author proposes a set of future research questions to more fully define the barriers to biomarkers research and to uncover which corrective measures may be effective. The author concludes by recommending an integration of regulatory and patent reforms, with a call to action by scholars, scientists, representatives of …

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An Introduction - Patents Versus Patients: Must We Choose, Cynthia M. Ho, Ann Weilbaecher Jan 2009

An Introduction - Patents Versus Patients: Must We Choose, Cynthia M. Ho, Ann Weilbaecher

Annals of Health Law and Life Sciences

No abstract provided.

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Diseases Endemic In Developing Countries: How To Incentive Innovation, Ann Weilbaecher Jan 2009

Diseases Endemic In Developing Countries: How To Incentive Innovation, Ann Weilbaecher

Annals of Health Law and Life Sciences

This comment addresses the inadequacies of research and development for diseases endemic in developing countries and explores how the patent system can inhibit innovation for new drugs for neglected diseases. The author analyzes four strategies to encourage innovation, including open source initiatives, patent pools, prizes, and wild card patent extensions, and examines how these alternative systems may spur innovation while balancing cost concerns held by drug manufacturers and purchasers. The author concludes that a combination of solutions may provide the best framework for the creation of essential medicines for neglected diseases.

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Patents With An "I" = Patients, Alice O. Martin, Sendil K. Devadas Jan 2009

Patents With An "I" = Patients, Alice O. Martin, Sendil K. Devadas

Annals of Health Law and Life Sciences

The authors address how patent protection in the United States is often quite narrow in scope, difficult to obtain, and insufficient in duration, thus stifling research and development of potential breakthrough pharmaceuticals. The authors further posit that countries that have enacted stronger intellectual property rights and research incentives have seen tremendous increases in foreign direct investment. In addressing critics of the current patent system, the authors show that alternatives to biotechnology patents would not demonstrably improve innovation and development of beneficial medicines. The authors conclude that given the substantial evidence of the patent system's benefits, and the mere speculation that …

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Legal, Ethical, And Conceptual Bottlenecks To The Development Of Useful Genomic Tests, Michael Tomasson Jan 2009

Legal, Ethical, And Conceptual Bottlenecks To The Development Of Useful Genomic Tests, Michael Tomasson

Annals of Health Law and Life Sciences

This article discusses advances in genomic research in the context of the debate surrounding gene patent rights and the limited rights of patient-participants in translational research. In addition, the author explores statutory and regulatory hurdles to advances in disease diagnosis, such the Bayh-Dole Act, Medicare Legislation, and the Health Insurance Portability and Accountability Act. The author questions the effectiveness of increasingly commercialized academic research and the limited success of the private sector in genomic research. The author concludes that future genomic research will require significantly increased patient participation, which may necessitate a reshaping of the pharmaceutical approach to medicine and …

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Captive Elephant Medicine: Recent Development, Ellen Wiedner, Dennis L. Schmitt Jan 2009

Captive Elephant Medicine: Recent Development, Ellen Wiedner, Dennis L. Schmitt

College of Agriculture

No abstract provided.

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Oil And Paper: Ownership, Economic Development, And Iraq's 2007 Draft Oil And Gas Law, Peter Jackson Jan 2009

Oil And Paper: Ownership, Economic Development, And Iraq's 2007 Draft Oil And Gas Law, Peter Jackson

Electronic Theses and Dissertations

The 2007 Draft Oil Law's parliamentary collapse demonstrates that Iraqi legislation must settle the issue of ownership prior to determining foreign investment rules. The draft law has been criticized by western academics for its economic benefits to international oil companies, but in Iraq the law has been rejected more for its ambiguities and its lack of specific ownership language, apart from four disputed, classified annexes listing classifications of oil fields. Rather than pass empty legislation and fill it up at a later point, Iraq must draft its oil revenue sharing laws, model contracts, and an oil ownership law in tandem …

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Trpv1 Mrna Is Differentially Expressed In Different Vertebral Levels Of Rat Dorsal Root Ganglia Following Sciatic Nerve Injury, Bree Zeyzus Johns Jan 2009

Trpv1 Mrna Is Differentially Expressed In Different Vertebral Levels Of Rat Dorsal Root Ganglia Following Sciatic Nerve Injury, Bree Zeyzus Johns

Electronic Theses and Dissertations

Transient Receptor Potential Vanilloid 1 plays an important role in the pain pathway. TRPV1 is expressed in primary afferent nociceptors and acts as a transducer for noxious stimuli; including capsaicin, toxins and noxious heat. TRPV1 protein expression increases in inflammatory and neuropathic pain models, but transcriptional regulation of TRPV1 remains unclear. In the present study, TRPV1 mRNA levels were measured in Dorsal Root Ganglia pertaining to the third, fourth and fifth vertebral levels of the lumbar spine following chronic constriction injury of the sciatic nerve in rats. TRPV1 mRNA levels are shown to increase in lumbar dorsal root ganglia in …

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Minimotif Miner 2nd Release: A Database And Web System For Motif Search, Sanguthevar Rajasekaran, Sudha Balla, Patrick R. Gradie, Michael R. Gryk, Krishna Kadaveru, Vamsi Kundeti, Mark W. Maciejewski, Tian Mi, Nicholas Rubino, Jay Vyas, Martin R. Schiller Jan 2009

Minimotif Miner 2nd Release: A Database And Web System For Motif Search, Sanguthevar Rajasekaran, Sudha Balla, Patrick R. Gradie, Michael R. Gryk, Krishna Kadaveru, Vamsi Kundeti, Mark W. Maciejewski, Tian Mi, Nicholas Rubino, Jay Vyas, Martin R. Schiller

Life Sciences Faculty Research

Minimotif Miner (MnM) consists of a minimotif database and a web-based application that enables prediction of motif-based functions in user-supplied protein queries. We have revised MnM by expanding the database more than 10-fold to approximately 5000 motifs and standardized the motif function definitions. The web-application user interface has been redeveloped with new features including improved navigation, screencast-driven help, support for alias names and expanded SNP analysis. A sample analysis of prion shows how MnM 2 can be used.

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"Education Will Be Our Mother": An Exploration Of Resilience Mechanisms Relating To The Educational Persistence Of Sudanese Refugees, Lucinda S. Spaulding Jan 2009

"Education Will Be Our Mother": An Exploration Of Resilience Mechanisms Relating To The Educational Persistence Of Sudanese Refugees, Lucinda S. Spaulding

Faculty Dissertations

The purpose of this study was to explore the cultural and contextual resilience mechanisms operating in the lives of Sudanese refugees living in Virginia. A convenience and snowball sampling of 10 Sudanese refugees (1 female, 9 male) living in Virginia were selected to participate in this study. Through interviews, I gathered and documented participant narratives. For the purpose of triangulation, I collected demographic information and data about the level of traumatic events experienced and the impact of these events using quantitative instruments. I analyzed the data using grounded theory methodology in order to explore the meaning attributed to past events …

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The Forgiving Family: Effects Of A Parent-Led Forgiveness Program On Mental And Relational Health, Chad Magnuson Jan 2009

The Forgiving Family: Effects Of A Parent-Led Forgiveness Program On Mental And Relational Health, Chad Magnuson

Faculty Dissertations

This study appraises the effects of a parent-led forgiveness intervention on mental health and relationship variables for parents and their third grade children (ages 8-9) in Belfast, Northern Ireland. In this study, parents in the experimental group (n = 5) used a curriculum guide to teach forgiveness to their children, while the control parents (n = 5) participated in art activities with their children. Statistical analyses demonstrated a significant increase in interpersonal forgiveness of an offender for parents who taught forgiveness to their child. No significant between-group differences were revealed for other mental health and relationship variables, either for children …

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Effects Of Light And Group Size On The Activity Of Wood Frog Tadpoles (Rana Sylvatica) And Their Response To A Shadow Stimulus, K. V. Mcclure, J. W. Mora, Geoffrey R. Smith Jan 2009

Effects Of Light And Group Size On The Activity Of Wood Frog Tadpoles (Rana Sylvatica) And Their Response To A Shadow Stimulus, K. V. Mcclure, J. W. Mora, Geoffrey R. Smith

Faculty Publications

No abstract provided.

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The Coffee House Classroom: The Difference Between Student And Faculty Perceptions Of Classroom Spatial Design In A Community College Environment, Katherine Kent Jan 2009

The Coffee House Classroom: The Difference Between Student And Faculty Perceptions Of Classroom Spatial Design In A Community College Environment, Katherine Kent

All-Inclusive List of Electronic Theses and Dissertations

With the ever increasing need for employees who are capable of problem solving, working in team-based projects, and engaging in professional discourse, it is questionable whether these activities are, or can be, supported and promoted in the typical community college classroom environment containing traditional rows of desks and computers with a professor front and center. These traditional classroom arrangements discourage participatory activities and engagements with peers and faculty due to the very nature of the inflexible and impersonal alignment of side-by-side, row seating. This study investigated the impact of the physical furnishings and the spatial arrangement of a classroom environment …

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The Biscayne Aquifer Of Southeastern Florida, Kevin J. Cunningham, Lee J. Florea Jan 2009

The Biscayne Aquifer Of Southeastern Florida, Kevin J. Cunningham, Lee J. Florea

Earth, Environmental, and Atmospheric Sciences Faculty Publications

No abstract provided.

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The Cumberland Plateau Of Eastern Kentucky, Larry C. Simpson, Lee J. Florea Jan 2009

The Cumberland Plateau Of Eastern Kentucky, Larry C. Simpson, Lee J. Florea

Earth, Environmental, and Atmospheric Sciences Faculty Publications

No abstract provided.

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Prospecting For Mammalian Chemical Signals Via Solventless Extraction Techniques: An Elephantine Task, Thomas Goodwin, Bruce A. Schulte Jan 2009

Prospecting For Mammalian Chemical Signals Via Solventless Extraction Techniques: An Elephantine Task, Thomas Goodwin, Bruce A. Schulte

Biology Faculty Publications

In contrast to a plethora of known insect pheromones, a paucity of mammalian pheromones has been identified, two of which have been in elephants (Albone, 1984; Brown and Macdonald, 1985; Wyatt, 2003; Burger, 2005). Elephants possess one of the world’s best chemosensory systems, due in no small measure to their prehensile trunk. The trunk is not only the gateway to smelling (primary olfaction), but also the means by which chemical signals are conveyed from their source to the openings of the vomeronasal organ ducts in the roof of the mouth (the flehmen response; secondary olfaction) (Rasmussen, 1999). The late L. …

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The Southeastern Coastal Plain: An Overview, Lee J. Florea, H. L. Vacher Jan 2009

The Southeastern Coastal Plain: An Overview, Lee J. Florea, H. L. Vacher

Earth, Environmental, and Atmospheric Sciences Faculty Publications

No abstract provided.

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Caves And Karst Of West-Central Florida, Lee J. Florea, David A. Budd, Robert B. Brinkman Jan 2009

Caves And Karst Of West-Central Florida, Lee J. Florea, David A. Budd, Robert B. Brinkman

Earth, Environmental, and Atmospheric Sciences Faculty Publications

No abstract provided.

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Popular Culture And The Denigration Of The Self, Eric Bain-Selbo Jan 2009

Popular Culture And The Denigration Of The Self, Eric Bain-Selbo

Philosophy & Religion Faculty Publications

No abstract provided.

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What's In A Word? On Reading--And Misreading--Alfred Russel Wallace, Charles H. Smith Jan 2009

What's In A Word? On Reading--And Misreading--Alfred Russel Wallace, Charles H. Smith

DLPS Faculty Publications

No abstract provided.

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Undergraduate Catalogue 2009-2010, Seton Hall University Jan 2009

Undergraduate Catalogue 2009-2010, Seton Hall University

Undergraduate Catalogues

No abstract provided.

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Graduate Catalogue 2009-2010, Seton Hall University Jan 2009

Graduate Catalogue 2009-2010, Seton Hall University

Graduate Catalogues

No abstract provided.

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Ham's Legacy: The Imbalance Of Power In Colonial Rwanda And The 1994 Genocide, Jennifer R. Phillips Jan 2009

Ham's Legacy: The Imbalance Of Power In Colonial Rwanda And The 1994 Genocide, Jennifer R. Phillips

Vulcan Historical Review

pp. 130-142

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Curing Nature-Deficit Disorder: How Environmental Education Helps Kids Learn, Jamie Leigh Langley Jan 2009

Curing Nature-Deficit Disorder: How Environmental Education Helps Kids Learn, Jamie Leigh Langley

Mahurin Honors College Capstone Experience/Thesis Projects

Walk into any public school and talk with the children about their experiences in nature and you will begin to see a pattern. Children have made few connections with the world around them. They do not spend much time outdoors and the time they do spend outdoors is not spent interacting directly with nature. Why does this matter? Look at these same kids and you will see another pattern emerging: Attention-Deficit Disorder, depression, obesity, emotional problems, etc. While not all of these problems are directly caused by a lack of interaction with the natural world, current research shows that there …

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Course Catalog 2009-2010, Laguardia Community College Jan 2009

Course Catalog 2009-2010, Laguardia Community College

Course Catalogs

No abstract provided.

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Biotechnology, Sustainability And Trust, Rebecca Bratspies Jan 2009

Biotechnology, Sustainability And Trust, Rebecca Bratspies

Publications and Research

No abstract provided.

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How Should The Effectiveness Of The Eppp Be Judged?, David Dilillo, George C. Tremblay Jan 2009

How Should The Effectiveness Of The Eppp Be Judged?, David Dilillo, George C. Tremblay

Department of Psychology: Faculty Publications

We join Brian A. Sharpless and Jacques P. Barber (2009) in calling for strengthening the evidence base supporting the Examination for Professional Practice in Psychology (EPPP), particularly in the areas of criterion and predictive validity. Although 1 clear purpose of the EPPP is to assess core areas of knowledge, materials from the Association of State and Provincial Psychology Boards are less clear as to whether the EPPP is also intended to predict future performance as a psychologist. If the EPPP is expected to protect the public from poorly trained psychologists, then data supporting its use for that purpose are urgently …

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Nonoffending Parent Expectations Of Sexually Abused Children: Predictive Factors And Influence On Children’S Recovery, Haig Kouyoumdjian, Andrea R. Perry, David J. Hansen Jan 2009

Nonoffending Parent Expectations Of Sexually Abused Children: Predictive Factors And Influence On Children’S Recovery, Haig Kouyoumdjian, Andrea R. Perry, David J. Hansen

Department of Psychology: Faculty Publications

This study examined the influence of parental expectations on the functioning of sexually abused children. Participants included 67 sexually abused youth and 63 of their nonoffending primary caregivers. Parental expectations about how sexual abuse will impact children were predictive of parents’ ratings of children’s behavior at pretreatment, while parental expectations of children’s overall future functioning were not predictive of parents’ ratings of children’s behavior. Parental expectations about how sexual abuse will impact their children and about their children’s overall future functioning were not predictive of parents’ ratings of children’s behavior at posttreatment. Results highlight the influential role the sexual abuse …

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Epigenetics, Oxidative Stress, And Alzheimer Disease, Nasser H. Zawia, Debomoy K. Lahiri, Fernando Cardozo-Pelaez Jan 2009

Epigenetics, Oxidative Stress, And Alzheimer Disease, Nasser H. Zawia, Debomoy K. Lahiri, Fernando Cardozo-Pelaez

Biomedical and Pharmaceutical Sciences Faculty Publications

Alzheimer disease (AD) is a progressive neurodegenerative disorder whose clinical manifestations appear in old age. The sporadic nature of 90% of AD cases, the differential susceptibility to and course of the illness, as well as the late age onset of the disease suggest that epigenetic and environmental components play a role in the etiology of late-onset AD. Animal exposure studies demonstrated that AD may begin early in life and may involve an interplay between the environment, epigenetics, and oxidative stress. Early life exposure of rodents and primates to the xenobiotic metal lead (Pb) enhanced the expression of genes associated with …

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Eugenia Jambolana Lam. Berry Extract Inhibits Growth And Induces Apoptosis Of Human Breast Cancer But Not Non-Tumorigenic Breast Cells, Liya Li, Lynn S. Adams, Shiuan Chen, Caroline Killian, Aftab Ahmed, Navindra P. Seeram Jan 2009

Eugenia Jambolana Lam. Berry Extract Inhibits Growth And Induces Apoptosis Of Human Breast Cancer But Not Non-Tumorigenic Breast Cells, Liya Li, Lynn S. Adams, Shiuan Chen, Caroline Killian, Aftab Ahmed, Navindra P. Seeram

Biomedical and Pharmaceutical Sciences Faculty Publications

The ripe purple berries of the native Indian plant Eugenia jambolana Lam., known as Jamun, are popularly consumed and available in the United States in Florida and Hawaii. Despite the growing body of data on the chemopreventive potential of edible berry extracts, there is paucity of such data for Jamun fruit. Therefore our laboratory initiated the current study with the following objectives: (1) to prepare a standardized Jamun fruit extract (JFE) for biological studies and (2) to investigate the antiproliferative and pro-apoptotic effects of JFE in estrogen dependent/aromatase positive (MCF-7aro), and estrogen independent (MDA-MB-231) breast cancer cells, and in a …

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