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Articles 10711 - 10740 of 818004
Full-Text Articles in Entire DC Network
Comparative Effect Of Mineral, Organic, And Mixed Sunscreens Formulations On The Life History Of A Benthic Marine Invertebrate, Jacob Anthony Fox, Courtney Lott, Araceli Rodriguez-Romero, Gloria Massamba N'Siala
Comparative Effect Of Mineral, Organic, And Mixed Sunscreens Formulations On The Life History Of A Benthic Marine Invertebrate, Jacob Anthony Fox, Courtney Lott, Araceli Rodriguez-Romero, Gloria Massamba N'Siala
Knowledge and Creativity Expo
Mineral and organic sunscreens are emerging anthropogenic pollutants in coastal marine waters and have been shown to affect marine invertebrates via genotoxicity, endocrine disruption, oxidative stress, and impacts on life-history traits, such as reduced survival, growth, and fecundity. Most experiments expose marine organisms to isolated UV filters, with fewer studies testing complete formulations, co-occurring exposure to organic and mineral sunscreens, or the modulating influence of format type on toxicity. In this experiment, we tested the impact of organic sunscreens (3% Avobenzone, 15% Homosalate, 5% Octinoxate, and 10% Octocylene) and 24% zinc oxide mineral sunscreens on the survival and fecundity of …
Effects Of Alk2 Deficiency On T Cell Fate And Regulatory T Cell Populations, Jalyn Reeves, Afia Salsabil Alam
Effects Of Alk2 Deficiency On T Cell Fate And Regulatory T Cell Populations, Jalyn Reeves, Afia Salsabil Alam
Knowledge and Creativity Expo
Regulatory T cells (Tregs) are central to immune tolerance, and their lineage stability is established during thymic development and maintained in the periphery through tightly regulated signaling networks. Members of the BMP receptor family have been implicated in T-cell differentiation, yet the specific role of the type I receptor ALK2 in shaping cell fate and sustaining the regulatory program remains unclear. To examine how ALK2 contributes to T-cell development, we generated ALK2-knockout murine chimeras and analyzed lymphoid populations from the thymus, spleen, and peripheral tissues. Thymocytes and lymphocytes were isolated and stained with antibody panels to identify developmental subsets and …
Interview With Orca Award Winner David Hage, Unl Chemistry; Drug-Protein Interactions, Mark Griep, David Hage
Interview With Orca Award Winner David Hage, Unl Chemistry; Drug-Protein Interactions, Mark Griep, David Hage
UNL ORCA Interview Series
Prof. David Hage was awarded the ORCA in 2018. He was born in La Crosse, Wisconsin, and earned a bachelor’s in chemistry at the University of Wisconsin in La Crosse. Next, he earned a doctorate from Iowa State University and did postdoctoral work at the Mayo Clinic in Rochester, Minnesota. In 1989, he joined UNL as an assistant professor of chemistry and quickly rose through the ranks. He has won many awards and, for the past 13 years, has been the James Hewet University Professor of Chemistry. Allow me to share some remarkable facts about Dave before we get into …
Variable Responses To Surface Washing Methods Used On Euplatypus Compositus (Curculionidae: Platypodinae) Prior To Fungal Isolation, Connor Biser, Jiri Hulcr, Miranda Barnes, Seth Bybee
Variable Responses To Surface Washing Methods Used On Euplatypus Compositus (Curculionidae: Platypodinae) Prior To Fungal Isolation, Connor Biser, Jiri Hulcr, Miranda Barnes, Seth Bybee
Library/Life Sciences Undergraduate Poster Competition 2026
Ambrosia beetles (Platypodinae and Scolytinae) are a group of weevils that burrow into the xylem of trees and inoculate symbiotic fungi. These fungi grow in the walls of their galleries and serves as the beetles’ food source.1 [Fig. 1] This system of symbiotic interaction is highly convergent, and some beetles carry plant pathogens.2 Understanding the community of fungi associated with ambrosia beetles can help us assess forest risks and describe evolutionary patterns. When isolating fungi from beetles, researchers often include a preliminary surface washing step to limit superficial contaminants from the surface of the beetle. There have been no comparisons …
Unlikely Relationships: Plant Growth Promotion With Fish Waste Microbes, Thomas W. Scharf, Brad Geary
Unlikely Relationships: Plant Growth Promotion With Fish Waste Microbes, Thomas W. Scharf, Brad Geary
Library/Life Sciences Undergraduate Poster Competition 2026
1st Place - Open House Presentation
- Aiding plant growth is becoming more important as climate conditions continue changing in key wildlands and farmlands.
- Future Fresh Farms has created a product from fish waste, addressing this need.
- This study aimed to compare the outcomes of plants grown with MicroRevive, derived from fish waste, against plants grown with other growth promoting bacteria (PGPB).
Uncovering The Roles Of Environment And Phylogeny In The Expression Of A Shared Morphological Trait In Squamates, Austin Rejcek, Dylan Mcmullen, Logan Gren, Randy L. Klabacka
Uncovering The Roles Of Environment And Phylogeny In The Expression Of A Shared Morphological Trait In Squamates, Austin Rejcek, Dylan Mcmullen, Logan Gren, Randy L. Klabacka
Library/Life Sciences Undergraduate Poster Competition 2026
Addressing the roles of adaptive and nonadaptive processes in trait evolution is a major focus of evolutionary biology
Recently, we observed an undescribed morphological trait on the eyelids of squamate lizards - AKA ''Palpebral combs'' (See photos)
This trait appears to be widespread within lguania, although there is consistent morphological variation between species of varying ecologies
The Role Of Nmda And Mglur5 Receptors On Hippocampal Depotentiation, J.H. Cummings, E. Sandberg, J.G. Edwards
The Role Of Nmda And Mglur5 Receptors On Hippocampal Depotentiation, J.H. Cummings, E. Sandberg, J.G. Edwards
Library/Life Sciences Undergraduate Poster Competition 2026
Depotentiation of LTP, the cellular mechanism of learning and memory, is thought to be the primary mechanism of forgetting.
Prior research in our lab investigated metabotropic glutamate receptor 5 (mGluR5) and its role in depotentiation and noted differences between males and females.
Preliminary data on NMDA receptors using AP5 (an antagonist) identified interesting findings, though n values are too low currently to draw conclusions.
Species Dynamics And Potential Invasion In The Restored Streams Of East Maui, Hannah Breinholt, Isabelle Hunter, Sarah Cole, Seth M. Bybee, Rachel L. Wood
Species Dynamics And Potential Invasion In The Restored Streams Of East Maui, Hannah Breinholt, Isabelle Hunter, Sarah Cole, Seth M. Bybee, Rachel L. Wood
Library/Life Sciences Undergraduate Poster Competition 2026
100+ years of water diversions in East Maui disrupted this connectivity, threatening native species and their habitat
In 2018, stream flow was restored to 22 streams
Endemic amphidromous fish in East Maui streams depend on intact flow from mountains to sea (mauka-to-makai) and are especially vulnerable to habitat disruption and isolation [1]
Has stream restoration enabled native fish species to recolonize or has it created openings for non-native species?
Shoot Apical Meristem Size And Inflorescence Morphology In Gilia, Madeleine Glover, Clinton Whipple
Shoot Apical Meristem Size And Inflorescence Morphology In Gilia, Madeleine Glover, Clinton Whipple
Library/Life Sciences Undergraduate Poster Competition 2026
Gilia, a genus of wildflower native to the western United States, is a promising new model for evolutionary developmental biology. Two closely related Gilia species, G. capitata and G. yorkii, are able to produce a fertile hybrid, though they differ in many morphological features, including inflorescence architecture. G. capitata has a tight capitate inflorescence with a high solitary flower number, while G. yorkii has a much more open inflorescence, with a solitary flower number of one. Analysis of shoot apical meristem (SAM) size in relationship with solitary flower number (SFN) will provide a deeper understanding of the evolution of this …
Self-Reported Longest-Held Occupation Type In Relation To Epilepsy In Late Life: A Pooled Cohort Analysis Of Incidence And Prevalence, Daniel Guerrero Gutierrez, Sofia Pelagalli Maia, Hyunmi Choi, Jose Gutierrez, Natalie Bello, Mary L. Biggs, Emily M. Briceño, James F. Burke, Lisandro D. Colantonio, Mitchell S.V. Elkind, Annette L. Fitzpatrick, Christopher Gonzalez, Alden L. Gross, Lei Huang, Emily L. Johnson, W. Craig Johnson, Cheng-Shiun Leu, Deborah A. Levine, Minghua Liu, W.T. Longstreth Jr., Richard P. Mayeux, Sylwia Misiewicz, Dolly Reyes-Dumeyer, Tatjana Rundek, Danurys Sanchez, Steven J. Shea, Tian Wang, Carolyn W. Shu, Evan L. Thacker
Self-Reported Longest-Held Occupation Type In Relation To Epilepsy In Late Life: A Pooled Cohort Analysis Of Incidence And Prevalence, Daniel Guerrero Gutierrez, Sofia Pelagalli Maia, Hyunmi Choi, Jose Gutierrez, Natalie Bello, Mary L. Biggs, Emily M. Briceño, James F. Burke, Lisandro D. Colantonio, Mitchell S.V. Elkind, Annette L. Fitzpatrick, Christopher Gonzalez, Alden L. Gross, Lei Huang, Emily L. Johnson, W. Craig Johnson, Cheng-Shiun Leu, Deborah A. Levine, Minghua Liu, W.T. Longstreth Jr., Richard P. Mayeux, Sylwia Misiewicz, Dolly Reyes-Dumeyer, Tatjana Rundek, Danurys Sanchez, Steven J. Shea, Tian Wang, Carolyn W. Shu, Evan L. Thacker
Library/Life Sciences Undergraduate Poster Competition 2026
Epilepsy in late life is influenced by biological, behavioral, social and environmental factors
Lifetime occupation type may capture socioeconomic, environmental, and long-term physical exposures relevant to brain health (e.g., manual labor, stress levels, neurotoxic exposures) that could influence neurological aging
Seizure Propagation And How Ketones May Help Mitigate Harmful Effects, Jacob Wassmer, Melissa L. Blotter, Isaac Stubbs, R. Ryley Parrish
Seizure Propagation And How Ketones May Help Mitigate Harmful Effects, Jacob Wassmer, Melissa L. Blotter, Isaac Stubbs, R. Ryley Parrish
Library/Life Sciences Undergraduate Poster Competition 2026
Status epilepticus (SE) is a seizure state characterized by continuous ictal activity lasting over 5 minutes. SE frequently becomes unresponsive to frontline antiepileptic drugs (AEDs), resulting in refractory status epilepticus (RSE), a neurological medical emergency with a mortality rate as high as 38% in some studies. To assess how SE develops over time, we have characterized an ex vivo brain slice SE model using a high-resolution multi-electrode recording system. The system contains over 4000 electrodes with less than 60μM of space in between each electrode. With this unprecedented spatial and temporal resolution, we have identified key features of SE that …
Research Process Toward The Creation Of Transgenic Beetles, Abraham B. Alton, Nathan Dauk, Jonah Jex, Brian D. Jensen, Sandra Hope
Research Process Toward The Creation Of Transgenic Beetles, Abraham B. Alton, Nathan Dauk, Jonah Jex, Brian D. Jensen, Sandra Hope
Library/Life Sciences Undergraduate Poster Competition 2026
Honorable Mention - Poster Design
Create a generalizable, reliable, and efficient procedure for insect genetic modification.
Insects born parasitic diseases such as malaria cause hundreds of millions of deaths each year. Many of these diseases could be eliminated if we had a reliable method for genetically modifying insects.
Potential Role Of Atr In Slower Aids Progression Associated With Hiv-1 Vpr Mutant R77q, Ava Wilstead, Sidney T. Sithole, Bradford K. Berges
Potential Role Of Atr In Slower Aids Progression Associated With Hiv-1 Vpr Mutant R77q, Ava Wilstead, Sidney T. Sithole, Bradford K. Berges
Library/Life Sciences Undergraduate Poster Competition 2026
HIV-1 typically induces necrotic T cell death, resulting in chronic inflammation that drives Acquired Immunodeficiency Syndrome (AIDS) progression. However, mutations in viral protein R (Vpr) are associated with altered disease outcomes. The HIV-1 Vpr mutant R77Q is linked to individuals that do not progress to AIDS without treatment, termed a longterm non-progressor (LTNP). The Berges lab has shown that R77Q infection results in reduced overall cell death compared to wild-type (WT) virus, while inducing increased apoptotic cell death.
Muscle Transplants: Science Fiction Or Modern Medicine?, Erastus Evans, Mason Kephart, Benjamin Long, Jake Sorensen
Muscle Transplants: Science Fiction Or Modern Medicine?, Erastus Evans, Mason Kephart, Benjamin Long, Jake Sorensen
Library/Life Sciences Undergraduate Poster Competition 2026
The loss of skeletal muscle from trauma or surgery results in limited regeneration and long-term dysfunction. Muscle transplants replenish lost cellular and structural tissue to improve healing and recovery of strength. Juvenile tissue offers a promising alternative to adult tissue due to the increased satellite cell and myofiber content.
Meta Analysis Of The Riverine Barrier Hypothesis In Mainland Southeast Asia, Gavin Kohl, Christian Furness, Eleanor Savage, Perry Van Wagoner, Randy Klabacka
Meta Analysis Of The Riverine Barrier Hypothesis In Mainland Southeast Asia, Gavin Kohl, Christian Furness, Eleanor Savage, Perry Van Wagoner, Randy Klabacka
Library/Life Sciences Undergraduate Poster Competition 2026
Understanding the drivers of biodiversification is an important objective in evolutionary biology
Yet much is still unknown regarding the mechanisms that drive biodiversity in species
Identifying barriers between lineages is a viable approach to discovering potential drivers
Iron Nutrition In Hydroponically Grown Quinoa, Ezra A. Larsen, Daniel L. Lamb, Shannon V. Nelson, Geneva M. Bell, Bryan G. Hopkins
Iron Nutrition In Hydroponically Grown Quinoa, Ezra A. Larsen, Daniel L. Lamb, Shannon V. Nelson, Geneva M. Bell, Bryan G. Hopkins
Library/Life Sciences Undergraduate Poster Competition 2026
- Iron (Fe) deficiency is a global health challenge
- Fe is an essential plant nutrient and limiting factor for many food crops
- Quinoa (Chenopodium quinoa Willd.), a nutrient dense pseudocereal, is of growing importance for food security
- Quinoa is often grown in alkaline soil, where Fe is particularly limiting
- An improved understanding of how Fe affects quinoa growth could improve yields and help increase dietary iron intake
Investigating The Role Of Tnf In Hiv-1 Infected Cell Death, Brennan B. Wells, Sidney Sithole, Bradford Berges
Investigating The Role Of Tnf In Hiv-1 Infected Cell Death, Brennan B. Wells, Sidney Sithole, Bradford Berges
Library/Life Sciences Undergraduate Poster Competition 2026
HIV-1 is the causative agent of the terminal disease AIDS. Clinical studies have determined that patients infected with a mutant of HIV-1, Vpr-R77Q, do not progress towards AIDS. Subsequently, our lab has discovered two notable differences between the Vpr- R77Q variant and WT HIV-1: increased levels of apoptosis in infected cells (which is thought to contribute to the lack of AIDS progression), and decreased levels of inflammatory cytokines, namely Tumor Necrosis Factor (TNF). The purpose of this ongoing experiment is to investigate the potential inverse correlation between TNF levels and apoptosis levels through the introduction of additional TNF cytokines to …
Investigating The Mechanisms Of Yersinia Ruckeri Inhibition By A New Strain Of Pseudomonas Fjordensis, Kyler Linton, David Erickson
Investigating The Mechanisms Of Yersinia Ruckeri Inhibition By A New Strain Of Pseudomonas Fjordensis, Kyler Linton, David Erickson
Library/Life Sciences Undergraduate Poster Competition 2026
Pacific freshwater fish are less likely than Atlantic freshwater fish to exhibit Enteric Redmouth Disease (ERM), or Yersiniosis as caused by Yersinia ruckeri. Based on the hypothesis that these fish may harbor commensal bacteria that inhibit Y. ruckeri growth, I isolated many kinds of commensal bacteria from fish intestines collected from Alaska and local streams. In previous studies, I have isolated novel bacteria capable of expressing inhibitory activity against Y. ruckeri via co-culture experiments. One of these bacteria is a strain of Pseudomonas fjordensis. Through genome-wide mutagenesis techniques, a possible gene has been unveiled that may be contributing to this …
Interactive Effects Of Salinity And Glyphosate On Wetland Soil Microbial Communities, Ryan Mortensen, Madison Brown, Rachel Wood
Interactive Effects Of Salinity And Glyphosate On Wetland Soil Microbial Communities, Ryan Mortensen, Madison Brown, Rachel Wood
Library/Life Sciences Undergraduate Poster Competition 2026
Wetland soil microbes play an important role in maintaining ecosystem health by cycling nutrients, breaking down organic matter, and maintaining water quality. Herbicide exposure has been shown to alter the genetic composition and functional potential of soil microbial communities, including shifts in microbial nutrient cycling processes [1].
Two of the most prominent environmental stressors in Utah’s wetlands are excessive salinity and herbicide exposure. Increased salinity can change how herbicides move and persist in water, which may influence their ecological effects [2]. While each stressor has been studied independently, little is known about their combined effects on soil microbial community structure …
In Silico Studies Of Hiv-1 Vpr R77q Mutant’S Structure And Stability, Linnea Mason, Sidney T. Sithole, Bradford K. Berges
In Silico Studies Of Hiv-1 Vpr R77q Mutant’S Structure And Stability, Linnea Mason, Sidney T. Sithole, Bradford K. Berges
Library/Life Sciences Undergraduate Poster Competition 2026
Human immunodeficiency virus type 1 (HIV-1) is a retrovirus that infects CD4+ T cells. Without treatment, infection with HIV-1 usually leads to acquired immunodeficiency syndrome (AIDS), which is characterized as severe immunosuppression (CD4+ count: < 200cells/mm3 of blood). However, some individuals do not advance to AIDS and are known as long-term non-progressors (LTNP). Interestingly, a small viral protein of HIV-1, called viral protein R (Vpr), has been associated with HIV-1 progression. The R77Q mutant has been linked to the LTNP phenotype and increased levels of apoptosis; however, the mechanisms behind it are not yet understood [1]. Previously, our group has found that Vpr was expressed at lower levels in cells infected with R77Q virus compared to the wildtype (WT) virus by western blot [1]. Image quantification of the bands showed an approximate six-fold reduction in protein levels.
Genetic And Morphological Comparison Between Introduced And Native Populations Of Aspidocelis Neomexicanus, Sadie Hale, Jordan Kirk, Arianna Moore, Perry Van Wagoner, Vicente Fernández Lara, Angelina Romero, Dallin Matthews, Álvaro Osuna Jiménez, Reagan Mckee, Randy Klabacka
Genetic And Morphological Comparison Between Introduced And Native Populations Of Aspidocelis Neomexicanus, Sadie Hale, Jordan Kirk, Arianna Moore, Perry Van Wagoner, Vicente Fernández Lara, Angelina Romero, Dallin Matthews, Álvaro Osuna Jiménez, Reagan Mckee, Randy Klabacka
Library/Life Sciences Undergraduate Poster Competition 2026
The introduction of non-native species to novel ecosystems can have negative impacts on the environment, economy, and human health.
Understanding the processes driving patterns in dispersion, establishment, and expansion of introduced species can illuminate strategies to reduce the occurrence of introduction and mitigate its effects.
The New Mexico Whiptail (Aspidoscelis neomexicanus) is a parthenogenetic (asexually-reproducing) species of lizard in the family Teiidae.
Exploring The Impact Of Redox Perturbations On Optic Tectum Development And Behavior, Kevin Gray, Bailey Calder, Daniel Andersen, Parker Hamblin, Michael Zeyer, Arminda Suli
Exploring The Impact Of Redox Perturbations On Optic Tectum Development And Behavior, Kevin Gray, Bailey Calder, Daniel Andersen, Parker Hamblin, Michael Zeyer, Arminda Suli
Library/Life Sciences Undergraduate Poster Competition 2026
The optic tectum (OT), the non-mammalian counterpart of the mammalian superior colliculus (SC), integrates multisensory information and orchestrates behavioral responses such as reflexive movements and attention shifts. It is localized in the midbrain, where anterior-posterior patterning is regulated by transcription factors dependent on proper endogenous H2O2 levels. Recent studies have implicated the OT/SC and early redox imbalance in neurodevelopmental disorders such as autism spectrum disorder (ASD). Given the importance of H2O2 in midbrain development, we are investigating how redox perturbations may lead to atypical OT circuitry development and, subsequently, result in aberrant behavioral phenotypes, similar to those associated with ASD. …
Enhancing Metabolic Fitness Of Car T-Cells By Removing Cd6, Nate Neyman, Alka Guar, Annie Joy-Larson, Collin Mickelson, Scott Weber
Enhancing Metabolic Fitness Of Car T-Cells By Removing Cd6, Nate Neyman, Alka Guar, Annie Joy-Larson, Collin Mickelson, Scott Weber
Library/Life Sciences Undergraduate Poster Competition 2026
Honorable Mention - Poster Design
CAR T-cell therapy is a highly effective cancer treatment involving engineering the patient’s T-cells to recognize and kill cancerous cells. This therapy has shown great success for blood cancers but has faced many challenges against solid tumors.
Surrounding tumor cells there is a lack of essential nutrients (oxygen, glucose) for T-cells to metabolize efficiency. Additionally, there is a buildup of excess waste products that directly impair T-cell function (1). To overcome these obstacles, scientists are working on developing longer lasting T-cells with improved metabolism to improve efficacy against cancer cells.
The Story Behind The Waves: Effects Of Urbanization And Female Presence On Waving Behavior In Fiddler Crabs, Katelyn Hansen, Blaine Griffen
The Story Behind The Waves: Effects Of Urbanization And Female Presence On Waving Behavior In Fiddler Crabs, Katelyn Hansen, Blaine Griffen
Library/Life Sciences Undergraduate Poster Competition 2026
Animal communication plays a central role in survival and reproduction, allowing individuals to convey information about their quality, territory, and reproductive statuses. Because signaling behaviors are often energetically costly and are dependent on both social contexts and habitat, they are sensitive to environmental conditions. Previous research has shown that male sand fiddler crabs (Leptuca pugilator) produce two distinct wave types: D-waves (typically directed towards other males) and up-and-down waves (typically directed toward females), and that they also reduce their waving behavior under urban stress. Urbanization introduces stressors such as habitat alteration and increased disturbances that can change the frequency and …
Discovery Of Short Antimicrobial Peptides In A Periplasmic Expression System, Joel Griffitts, Adam Dunn, Caleb Parker, Matthew Steed
Discovery Of Short Antimicrobial Peptides In A Periplasmic Expression System, Joel Griffitts, Adam Dunn, Caleb Parker, Matthew Steed
Library/Life Sciences Undergraduate Poster Competition 2026
Short Antimicrobial peptides (sAMPs) have the potential to make a significant impact in the ongoing battle against antibiotic-resistant bacteria. In this project, we aim to discover new sAMPs using a novel peptide expression system in E. coli. Using this system, we have successfully identified various sAMPs by testing both rationally designed peptides and randomized peptide libraries.
Derivation And Validation Of Age-Associated Prognostic Gene Signatures Across Breast Cancer Subtypes, John Speers, Adrienne Parsons, Elizabeth Feliciano, Sandra Mcallister, Lindsey Hale
Derivation And Validation Of Age-Associated Prognostic Gene Signatures Across Breast Cancer Subtypes, John Speers, Adrienne Parsons, Elizabeth Feliciano, Sandra Mcallister, Lindsey Hale
Library/Life Sciences Undergraduate Poster Competition 2026
Relatively little research has been done investigating the effects of linear age on breast-cancer specific mortality . The development of age-associated gene signatures may reveal interesting gene-set patterns with therapeautic potential. We hypothesize that the separation of patients into age categories will yield more predictive gene-signatures than an age-agnostic approach.
Colorful Proteins: Engineering A Palette Of Novel Chromoprotein Variants, Blake Olson, Anna Bowman, Kyler Fullmer, Joel Griffitts
Colorful Proteins: Engineering A Palette Of Novel Chromoprotein Variants, Blake Olson, Anna Bowman, Kyler Fullmer, Joel Griffitts
Library/Life Sciences Undergraduate Poster Competition 2026
2nd Place - Poster Design
- Chromoproteins (CP) are naturally occurring proteins originating from corals or other marine invertebrates that exhibit colors determined by their chromophore region.1
- CPs have applications as biosensors, teaching tools, and agar art; therefore, there is a need for a wide variety of CPs.2
- Hypothesis: Editing amino acid residues around the chromophore will change the chromophore’s conformation, leading to a change in color.
Cholesterol‑Containing Membranes Decrease The Helicity Of The Snare Protein Snap‑25, Christopher E. Hunt Jr., Jason T. Carlson, Michael B. Connell, Fatima D. Dagohoy, Mike Sumison, Jonathan Madsen, Chase M. Tingen, Azer E. White, Tanner M. Blocker, Dixon J. Woodbury
Cholesterol‑Containing Membranes Decrease The Helicity Of The Snare Protein Snap‑25, Christopher E. Hunt Jr., Jason T. Carlson, Michael B. Connell, Fatima D. Dagohoy, Mike Sumison, Jonathan Madsen, Chase M. Tingen, Azer E. White, Tanner M. Blocker, Dixon J. Woodbury
Library/Life Sciences Undergraduate Poster Competition 2026
Neurotransmitter release in neurons requires membrane fusion between synaptic vesicles and the presynaptic membrane. Lipids in both membranes merge through the action of SNARE proteins including SNAP-25. Changes in SNAP-25 structure or lipid composition likely modify this process. SNAP-25 has two isoforms, SNAP-25A (25A) and SNAP-25B (25B), the expression patterns of these isoforms vary throughout different brain regions and neuronal developmental stages. In vivo SNAP-25 anchors to the presynaptic membrane via attachment of palmitic acid to at least one of the four cysteines. Here we show mixing SNAP-25 (not palmitoylated) with liposomes alters both protein structure and lipid properties. Using …
C-Fms Expresses In Early Progenitor Cells & Myeloid-Lineage Leukocytes Based On Analyzing Lineage Markers And Mapping On Ly6c X Cd31 Plots In Bone Marrow, Jane Lundgren, Kelly Amsden, Evan Boesl, Victoria Hall, Emily Shakespear, Pam Van Ry, Sandra Hope
C-Fms Expresses In Early Progenitor Cells & Myeloid-Lineage Leukocytes Based On Analyzing Lineage Markers And Mapping On Ly6c X Cd31 Plots In Bone Marrow, Jane Lundgren, Kelly Amsden, Evan Boesl, Victoria Hall, Emily Shakespear, Pam Van Ry, Sandra Hope
Library/Life Sciences Undergraduate Poster Competition 2026
The Mafia mouse model expresses the green fluorescent protein (GFP) in cells that utilize the macrophage-specific c-fms promoter. The c-fms promoter controls expression of receptor for Colony Stimulating Factor 1. We hypothesize that this promotor may be utilized in bone marrow progenitor cells in addition to the mature cell expression already known in macrophage lineage cells. For this study, bone marrow cells were analyzed by flow cytometry for the expression of c-fms, early progenitor markers, and lineage-specific markers. Expression was also mapped on a Ly6CxCD31 plot, which has been used to distinguish cells based on developmental stage and lineage. This …
Cd6-Knockout Car-T Cells Display Enhanced Cytotoxicity Against Lymphoma Cell Line, Annie Larson, Alka Gaur, Nate Neyman, Collin Mickelson, K. Scott Weber
Cd6-Knockout Car-T Cells Display Enhanced Cytotoxicity Against Lymphoma Cell Line, Annie Larson, Alka Gaur, Nate Neyman, Collin Mickelson, K. Scott Weber
Library/Life Sciences Undergraduate Poster Competition 2026
Chimeric antigen receptor (CAR)-T cells are genetically engineered T cells that target surface antigens on cancer cells, showing remarkable effectiveness in treating blood cancers [1]. However, CAR-T cells are currently not effective in treating solid tumors, as the tumor microenvironment poses physical and metabolic barriers to effective CAR-T cell function. A notable strategy for increasing CAR-T cell cytotoxicity in a tumor microenvironment is knocking out or overexpressing some genes of the T cell.