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Rhinovirus-Associated Wheezing And Asthma In Young Children, Zofia Piotrowska

Yale Medicine Thesis Digital Library

Human rhinoviruses (HRV) are a common cause of the common cold, and are thought to be associated with asthma exacerbations in both children and adults. Recently, HRV have been identified as a major cause of hospitalization in children < 5 years old. The purpose of this study was too determine whether HRV are a cause of either wheezing and/or hospitalization in children < 2 years old. We used a PCR assay to screen for HRV infection in children < 2 years old: 1) with symptoms of upper or lower respiratory tract disease without wheezing; 2) with wheezing; 3) who were asymptomatic. A group of children who had a respiratory specimen submitted to a diagnostic laboratory for whatever reason and who tested negative for four common viruses in the clinical lab were also screened. All specimens were collected between January 1 and December 31, 2004. Phylogenetic analyses were performed on a majority of HRV isolates. Overall, 28 (17%) of 165 children with symptoms of respiratory traction infection without wheezing; 21 (26.3%) of 80 children with symptoms of respiratory tract infection and wheezing; 3 (3%) of 93 asymptomatic children and 47 (23.3%) of 202 children with specimens submitted to the diagnostic laboratory tested positive for HRV. The difference between the rate of infection in the asymptomatic group and each of the three other groups was statistically significant (p<0.01). Among children with samples submitted to the diagnostic laboratory in whom HRV was the only identified pathogen, 55% were hospitalized. This rate was similar to that observed for respiratory syncytial virus (52.7%) among children of a similar age group and time period (P=0.85). Diverse groups of HRV were circulating during the one-year study period. We conclude that HRV are important pathogens among young children < 2 years old and are responsible for a significant proportion of wheezing this age group. Among a group of children with a respiratory specimen submitted to the diagnostic laboratory in whom a rhinovirus was the only identified pathogen, a majority were hospitalized.

Frequency Of Tlr-2, 4, 9 And Cd14 Polymorphisms In Aggressive Periodontitis Population In African-Americans, Melanie Chou

Theses and Dissertations

Aim: The aim of this study is to determine the frequency of single nucleotide polymorphisms (SNPs) in various pattern recognition receptor (PRR) genes, including Toll like receptors (TLR) -2, -4, -9, and CD14 in chronic (CP), localized (LAP) and generalized aggressive (GAP) periodontitis and periodontally healthy (NP) patients in an African American population. Methods: A total of 205 subjects were involved in the study. The LAP group consists of 25 subjects, the GAP group 50 subjects, the CP group 73 subjects and the NP group 57subjects. Genotyping was performed in TLR2 (G2408A), TLR4 (A896G),TLR9 (T1486C) and CD14 (C260T) genes by …

A Comparison Of Fluoroquinolones Versus Other Antibiotics For Treating Enteric Fever: Meta-Analysis, Durrane Thaver, Anita K. M. Zaidi, Julia Critchley, Asma Azmatullah, Syed Ali Madni, Zulfiqar Ahmed Bhutta

Department of Paediatrics and Child Health

Objectives: To review evidence supporting use of fluoroquinolones as first line agents over other antibiotics for treating typhoid and paratyphoid fever (enteric fever).
Design: Meta-analysis of randomised controlled trials. Data sources: Cochrane Infectious Diseases Group specialised register, CENTRAL (issue 4, 2007), Medline (1966-2007), Embase (1974-2007), LILACS (1982-2007), selected conferences, reference lists, and ongoing trial register (November 2007).
Review methods: Trials comparing fluoroquinolones with chloramphenicol, cephalosporins, or azithromycin in culture-proven enteric fever were included. Two reviewers extracted data and assessed methodological quality. Odds ratios with 95% confidence intervals were estimated. Trials recruiting over 60% children were analysed separately from trials on …

Checkup, Lehigh Valley Health Network

Checkup

No abstract provided.

Progress Notes, Lehigh Valley Health Network

Progress Notes

No abstract provided.

The Burden Of Fetching Water: Using Caloric Expenditure As An Indicator Of Access To Safe Drinking Water—A Case Study From Xieng Khouang Province, Lao Pdr, Jeff La Frenierre

Electronic Theses and Dissertations

The Millennium Development Goals measure ‘access to improved drinking water’ using an indicator that defines access as the presence of an improved water source within 1 kilometer of a person’s dwelling. This purely linear measurement has significant shortcomings, including a lack of consideration for the difficulty of the terrain being traversed and the weight of the loads being carried. This paper examines in detail the human energy costs associated with fetching water, first using two Lao villages as case studies, then applying a predictive energy expenditure model to measure the potential caloric effect of variations in the age and gender …

Finfish Aquaculture In Western Australia. Final Esd Management Report For Marine Finfish Aquaculture., Department Of Fisheries Western Australia.

Fisheries Management Papers

It has been recognized that there are a number of potential impediments to achieving continued growth of this industry. These include the need for increased investment, an expansion in markets and ensuring environmental sustainability. One of the most important however, is meeting the growing expectations of the community that all aquaculture sectors can clearly demonstrate that they are operating within the principles of Ecologically Sustainable Development (ESD). Western Australia’s Department of Fisheries is responsible for the management of aquaculture in the State and is committed to implementing ESD. These principles are contained within the objectives of the Fish Resources Management …

Comparison Of Arthroscopic And Open Treatment Of Septic Arthritis Of The Wrist, Douglas M. Sammer, Alexander Y. Shin

Open Access Publications

No abstract provided.

Worldwide Review Of Pygmy Killer Whales, Feresa Attenuate, Mass Strandings Reveals Taiwan Hot Spot, Robert L. Brownell Jr., C.-J. Yao, Chia-Shan Lee, Ming-Chih Wang

United States Department of Commerce: Staff Publications

Pygmy killer whales, Feresa attentuata, are known worldwide from tropical to warm-temperate waters. The first recorded mass stranding event (MSE) of this species occurred in January 1968 in South Africa. We documented 16 MSEs to April 2006 in Bali, Indonesia. The number of animals involved in these MSEs ranged from 3 to 28, but most MSEs were less than eight animals. Taiwan was identified as a major hot spot for these MSEs with 25% of the events occurring since 1995 in a relatively small section of coastline in the south-west. Three additional near MSEs were documented from Taiwan between …

Pubh 580.01: Rural Health Issues In Global Context, Peter Koehn

University of Montana Course Syllabi, 1990-2010

No abstract provided.

Contract And Grant Awards Fiscal Year 2009, Office Of The Vice President For Research

Office of the Vice President for Research

No abstract provided.

Rrh Library Newsletter, June 2009, Libraries At Rochester Regional Health

Rochester Regional Health authored publications and proceedings

Newsletter sections include: A New Influenza Virus

Forage News [2009-06], Department Of Plant And Soil Sciences, University Of Kentucky

Forage News

• Hart County Hay Producer to Speak at AFGC
• Forage Workers Meet in Lexington
• Nominations Requested
• Kentucky Alfalfa Conference: 30th Anniversary
• UK Equine Field Day
• Rotational Grazing Benefits
• Adjust Conditioners for Maximum Drying
• Grazing Conference to be at Princeton
• UK Field Day - July 23
• Anderson County to Host KFGC Field Day
• KFGC and High Quality Forages
• Miscanthus - What is it?
• Upcoming Events

Commencement Program 2009, Loma Linda University

Commencement Programs

CONTENTS

2 | 2009 Events of Commencement

3 | The Academic Procession

4 | Significance of the Academic Regalia

5 | The Good Samaritan

6 | The Speakers

13 | The University Honorees

19 | The School Honorees

30 | The Program

• School of Medicine, 31
• School of Pharmacy, 46
• School of Dentistry, 51
• School of Science and Technology and School of Religion, 63
• School of Nursing, 71
• School of Allied Health Professions - Physical Therapy, 78
• School of Allied Health Professions, 86
• School of Public Health, 95

Evolutionary Demography And The Population History Of The European Early Neolithic, Stephen Shennan

Human Biology

In this paper I propose that evolutionary demography and associated theory from human behavioral ecology provide a strong basis for explaining the available evidence for the patterns observed in the fi rst agricultural settlement of Europe in the 7th–5th millennium cal. BC, linking together a variety of what have previously been disconnected observations and casting doubt on some long-standing existing models. An outline of relevant aspects of life history theory, which provides the foundation for understanding demography, is followed by a review of large-scale demographic patterns in the early Neolithic, which point to rapid population increase and a process of …

June 1, 2009 Reporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Alternative Life Cycle Strategies And Colonization Of Young Anurans By Gorgoderina Attenuata In Nebraska, Matthew G. Bolek, Scott D. Snyder, John J. Janovy Jr.

Biology Faculty Publications

Studies on life cycles and epizootiology of North American frog bladder flukes indicate that adult frogs become infected predominantly by ingesting tadpoles or other frogs that serve as second intermediate hosts for gorgoderid metacercariae. Other studies have indicated that newly metamorphosed frogs are rarely infected with these parasites because they are gape-limited predators that cannot feed on large intermediate hosts such as tadpoles and other frogs. We examined the role of potential intermediate hosts in the recruitment of the frog bladder fluke, Gorgoderina attenuata, to metamorphosed northern leopard frogs, Woodhouse’s toads, and bullfrogs from western Nebraska. We completed the …

Happiness And Punishment, John Bronsteen, Christopher Buccafusco, Jonathan Masur

University of Chicago Law Review

This Article continues our project of applying new findings in the behavioral psychology of human happiness to some of the most deeply analyzed questions in law. When a state decides how to punish criminal offenders, at least one important consideration is the amount of harm any given punishment is likely to inflict. It would be undesirable, for example, to impose greater harm on those who commit less serious crimes or to impose harm that rises to the level of cruelty. Our penal system fits punishments to crimes primarily by adjusting the size of monetary fines and the length of prison …

Terrestrial Ecosystem Adaptation, Steven W. Running, L. Scott Mills

Numerical Terradynamic Simulation Group Publications

In this report we evaluate adaptation issues for natural ecosystems. We will specifically focus on the interactions with the abiotic environment of plants and animals, along with other organisms with which they interact (e.g., disease-causing bacteria and viruses). We further limit ourselves to natural ecosystems in which the predominant vegetation has developed without having been planted, irrigated, or fertilized. Most of the natural lands in the United States are managed by federal or state governments. Agricultural lands— including range grazing lands — are dealt with in a related adaptation report. This will evaluate the potential magnitudes and challenges facing terrestrial …

Redescription Of The Frog Bladder Fluke Gorgoderina Attenuata From The Northern Leopard Frog, Rana Pipiens, Matthew G. Bolek, Scott D. Snyder, John J. Janovy Jr.

Biology Faculty Publications

Morphological characters used to differentiate North American bladder flukes, Gorgoderina spp., are problematic and different authors use different morphological characteristics for distinguishing species. More importantly, no type specimens exist for four of the 12 North American species infecting anuran and caudatan hosts. A redescription of Gorgoderina attenuata (Stafford, 1902) Stafford, 1905 is based on new collections from 6 species of anurans from Arkansas, Nebraska, New York, and Wisconsin. Morphological comparisons between gravid G. attenuata recovered from bullfrogs and northern leopard frogs indicated statistically significant differences in 11 of 28 morphological characters examined. However, there was overlap among all of these …

Developmental Implications Of Children's Virtual Worlds, Kaveri Subrahmanyam

Washington and Lee Law Review

As virtual worlds for children increase in popularity, it is important to examine their developmental implications. Given the limited research on this question, we use extant social science research on youth and digital media to understand how children 's participation in virtual worlds might mediate their development. We identify four different pathways by which new media can potentially mediate development. Then we review relevant research on video games, which, like virtual worlds, contain three-dimensional online fantasy worlds; we also review research on online communication forums, which are like virtual worlds in that they allow users to create online selves and …

Modeling And Analysis Of The Spread Of Japanese Encephalitis With Environmental Effects, Ram Naresh, Surabhi Pandey

Applications and Applied Mathematics: An International Journal (AAM)

A nonlinear mathematical model for the spread of Japanese Encephalitis, caused by infected mosquito feeding on susceptible human population incorporating demographic and environmental factors is proposed and analyzed. In the modeling process, it is assumed that the growth rates of reservoir animal population and vector mosquito population are enhanced due to environmental discharges caused by human population related factors. The model is analyzed by stability theory of differential equations and computer simulation. Both the disease-free and the endemic equilibria are found and their stability is investigated. It is found that whenever the disease-free equilibrium is locally asymptotically stable, the endemic …

Effects Of Spaceflight On Phagocytic Function And Immune-Neural Interaction, Farnaz P. Baqai

Loma Linda University Electronic Theses, Dissertations & Projects

In spaceflight, astronauts will be exposed to several environmental risk factors that may lead to disturbances in homeostasis maintained by the central nervous system (CNS) and immune system. Low Earth orbit (LEO) spaceflight studies have shown that microgravity changes virtually all immune parameters that have been evaluated. Similarly, ground based studies have shown that low-dose radiation can also significantly impact immune function. Finally, as most spacecrafts are ecologically and environmentally closed systems, astronauts may be at increased risk for exposure to aerosolized infectious agents. The hypothesis of this study is: Exposure to spaceflight environment (microgravity and radiation) can influence immune …

Tuberculosis In San Bernardino County, 1993-2004 : Lifestyle And Environmental Factors, Anuj Bhatia

Loma Linda University Electronic Theses, Dissertations & Projects

An observational retrospective study was conducted for tuberculosis (TB) cases between San Bernardino County (SBC), Riverside County, and the state of California from 1996 to 2004. A univariate comparison between San Bernardino County and California indicated a higher proportion of U.S. born cases in SBC. Additionally, it was found that San Bernardino had a higher proportion of non-injection drug using TB cases, compared with California in 1996. Further comparisons were made along country of birth between TB cases in San Bernardino County from 1993 to 2004. Notable differences were observed for injection drug use, non injection drug use, alcohol abuse, …

Detecting, Preventing, And Treating Sexually Transmitted Diseases Among Adolescent Arrestees: An Unmet Public Health Need, Steven Belenko, Richard Dembo, Matthew Rollie, Kristina Childs, Christopher Salvatore

Department of Justice Studies Faculty Scholarship and Creative Works

Studies of detained and incarcerated adolescent offenders in the United States indicate that these juveniles have an elevated risk of sexually transmitted diseases (STDs). However, many more arrestees enter the “front end” of the juvenile justice system that is detained or incarcerated, and research into the STD risk profiles and service needs of this larger group is lacking. An expansion of STD testing (including of asymptomatic youths), prevention, and treatment is needed, as is improved knowledge about gender- and race-specific services. A pilot program in Florida has shown that juvenile justice and public health systems can collaborate to implement STD …

Outbreak Of Dengue Fever In Karachi 2006: A Clinical Perspective, Muhammad Mehmood Riaz, Khalid Mumtaz, Muhammad Shoaib Khan, Junaid Patel, M. Tariq, Harith Hilal, Shaheryar Ahmed Siddiqui, Farrukh Shezad

Section of Internal Medicine

OBJECTIVE: This study reports clinical manifestations and spectrum of severity of dengue fever (DF), dengue haemorrhagic fever (DHF) and dengue shock syndrome (DSS) in adult patients admitted during 2006 outbreak in Karachi. A rough estimation of cost of care was also calculated.

METHODS: A cross-sectional study was done at a tertiary care hospital in Karachi from January to December 2006. Patients suspected of having DF with positive dengue IgM antibodies were included and records were reviewed. Patients were divided into DF, DHF and DSS as per WHO classification, and the severity of clinical manifestations was determined.

RESULTS: A total of …

High Order Literacy For The 21st Century - Improving The Quality Of Library Engagement, Tom Cochrane

Proceedings of the IATUL Conferences

No abstract provided.

Factors Contributing To Adolescent Obesity, Manal I. Al-Kloub, Erika S. Froelicher

Saudi Medical Journal

No abstract provided.

Intravenous Inoculation Of A Bat-Associated Rabies Virus Causes Lethal Encephalopathy In Mice Through Invasion Of The Brain Via Neurosecretory Hypothalamic Fibers., Mirjam A R Preuss, Marie-Luise Faber, Gene S Tan, Michael Bette, Bernhard Dietzschold, Eberhard Weihe, Matthias J Schnell

Department of Microbiology and Immunology Faculty Papers

The majority of rabies virus (RV) infections are caused by bites or scratches from rabid carnivores or bats. Usually, RV utilizes the retrograde transport within the neuronal network to spread from the infection site to the central nervous system (CNS) where it replicates in neuronal somata and infects other neurons via trans-synaptic spread. We speculate that in addition to the neuronal transport of the virus, hematogenous spread from the site of infection directly to the brain after accidental spill over into the vascular system might represent an alternative way for RV to invade the CNS. So far, it is unknown …

Single-Amino-Acid Alterations In A Highly Conserved Central Region Of Vesicular Stomatitis Virus N Protein Differentially Affect The Viral Nucleocapsid Template Functions, Debasis Nayak, Debasis Panda, Subash C. Das, Ming Lou, Asit K. Pattnaik

School of Veterinary and Biomedical Sciences: Faculty Publications

The nucleocapsid protein (N) of vesicular stomatitis virus and other rhabdoviruses plays a central role in the assembly and template functions of the viral N-RNA complex. The crystal structure of the viral N-RNA complex suggests that the central region of the N protein interacts with the viral RNA. Sequence alignment of rhabdovirus N proteins revealed several highly conserved regions, one of which spanned residues 282 to 291 (GLSSKSPYSS) in the central region of the molecule. Alanine-scanning mutagenesis of this region suggested that replacement of the tyrosine residue at position 289 (Y289) with alanine resulted in an N-RNA template that is …