Digital Commons Network^™

Noninvasive Measurement Of Aminolevulinic Acid-Induced Protoporphyrin Ix Fluorescence Allowing Detection Of Murine Glioma In Vivo, Summer L. Gibbs-Strauss, Julia A. O'Hara, P Jack Hoopes, Tayyaba Hasan, Brian W. Pogue

Dartmouth Scholarship

Aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) fluorescence is studied as a contrast agent for noninvasive detection of murine glioma, using the fluorescence-to-transmission ratio measured through the cranium. Signals measured prior to administration of ALA are very similar between control animals, 9L-GFP, and U251 tumor-bearing animals. However, 2 h after ALA administration, the PpIX signal from both tumor-bearing groups is significantly higher than the control group (9L-GFP group p-value=0.016, and U251 group p-value=0.004, relative to the control group). The variance in signal from the 9L-GFP group is much larger than either the control group or the U251 group, which is consistent …

Quantitative Imaging Of Scattering Changes Associated With Epithelial Proliferation, Necrosis And Fibrosis In Tumors Using Microsampling Reflectance Spectroscopy, Venkataramanan Krishnaswamy, P Jack Hoopes, Kimberley S. Samkoe, Julia A. O'Hara, Tayyaba Hasan, Brian W. Pogue

Dartmouth Scholarship

Highly localized reflectance measurements can be used to directly quantify scatter changes in tissues. We present a microsampling approach that is used to raster scan tumors to extract parameters believed to be related to the tissue ultrastructure. A confocal reflectance imager was developed to examine scatter changes across pathologically distinct regions within tumor tissues. Tissue sections from two murine tumors, AsPC-1 pancreas tumor and the Mat-LyLu Dunning prostate tumor, were imaged. After imaging, histopathology-guided region-of-interest studies of the images allowed analysis of the variations in scattering resulting from differences in tissue ultra-structure. On average, the median scatter power of tumor …

Supporting Clients On Methadone Maintenance Treatment, Registered Nurses' Association Of Ontario

General Submissions: Community and Population-based Materials

This guideline will focus on recommendations for any youth, adult or older adult either already on MMT or those who are potential candidates for MMT. Particular attention will be paid to priority populations (for whom there are particular physiological implications of MMT).

Environmental Law, Rachael Anderson-Watts, Naeha Dixit, Christopher J. Dunsky

Vanderbilt Law School Faculty Publications

The decisions of the Michigan Supreme Court and the Michigan Court of Appeals during the Survey period, May 23, 2007 to July 30, 2008, did not dramatically change the course of environmental law in Michigan, nor did they contain any major surprises. The state Supreme Court's decision in Michigan Citizens for Water Conservation v. Nestl Waters North America, Inc. is the most significant decision in the Survey period because it held that plaintiffs in Michigan Environmental Protection Act (MEPA) cases must now satisfy federal standing requirements. Although the Nestl9 decision may make it more difficult for ordinary citizens to use …

The Constitutionality Of State And Local Laws Targeting Immigrants, Karla M. Mckanders

Vanderbilt Law School Faculty Publications

This paper addresses current immigration issues across the country, specifically in Arkansas, and how lawyers can seek to achieve social justice for immigrants. There currently has been a lot of activity and discussion surrounding state and local laws targeting immigrants. Central to this discussion has been whether states and localities are constitutionally permitted to enact immigration laws and whether state and local actions upset the current immigration system and how, if at all, their actions affect documented and undocumented immigrants' rights. When states and localities pass immigration related laws, the main concern is whether federal, state or local governments are …

Ten Fingers, Ten Toes: Newborn Screening For Untreatable Disorders, Ellen Wright Clayton

Vanderbilt Law School Faculty Publications

This movie makes two important points despite its admitted unreality. The first, which the screen writer probably did not fully appreciate at the time, is that genetic testing cannot now and probably will never be able to predict with complete certainty the occurrence and course of complex diseases. It is not true that "Genes-R-Us." Rather, we are the products of complex interactions of our genes, the genomes of other organisms (many of which we live in relation with), and the environment, broadly understood to include the air we breathe, the water we drink, the food we eat, the drugs we …

Exploring The Television Portrayal Of Older People In Hong Kong : A Study Of Two Public Affairs Documentary Series, Caillie Tam

Lingnan Theses

Adopting the contextual social constructionist perspective on social problems, the present study investigates how older people are portrayed in two public affairs television documentaries in Hong Kong over a period of two decades. There were The Hong Kong Connection (produced by the public service broadcaster, Radio Television Hong Kong); and Chasing Current Affairs (produced by a commercial broadcaster, Asia Television Limited). A mixture of research designs was employed in the analysis, namely: (1) content analysis on the documentary episodes, (2) reviews of government documents and (3) in-depth interviews with social workers and the staff engaged in documentary episode productions. A …

Older Persons' Perceptions Of Their Future : A Qualitative Study In Hong Kong, Shuk Ching, Crystal So

Lingnan Theses

This study examines older persons’ hopes, fears and expectations for the future, a topic little explored in Hong Kong. The study of twenty-five people aged 65-85 years adopts a qualitative approach to explore the experiences that shape older persons’ views of their future lives. Three models emerged from the empirical study, namely The Model of Resignation, The Model of Predestination and The Model of Adaptation.

The findings suggest that respondents who had and still have little social support from friends tend to live very much in the present; they do not look forward to the future nor do they have …

Risk Culture Of Late Modernity? : Mass Tutoring Enrolment Of Hong Kong's Senior Secondary Students, Cheuk Wai, Jeffrey Cheung

Lingnan Theses

Mass tutoring on senior secondary curricula, with specific focus on examination syllabi and techniques, has expanded rapidly in Hong Kong in the recent decade. Through semi-structured in-depth interviews, conducted in summer 2007, with 20 certificate level (Secondary 4 and 5) and 21 advanced level (Secondary 6 and 7) students with various level of involvement in mass tutoring, this study discovered:

(1) Risk awareness and future-oriented mentality: Students expected that mass tutoring could help improve their performance in public examinations, and could secure good grades. To them, better grades mean higher chance to get a recognized qualification, fulfil their career aspiration, …

Does Private Equity Create Wealth? The Effects Of Private Equity And Derivatives On Corporate Governance, Randall Thomas, Ronald W. Masulis

Vanderbilt Law School Faculty Publications

Private equity has reaped large rewards in recent years. We claim that one major reason for this success is due to the corporate governance advantages of private equity over the public corporation. We argue that the development of substantial derivative contracts and trading has significantly weakened the governance of public corporations and has created a need for financially sophisticated directors and much closer supervision of management. The private equity model delivers these benefits and allows corporations to be better governed, creating wealth gains for investors.

A Defense Of The Integrationist Test As A Replacement For The Special Defense Of Insanity, Christopher Slobogin

Vanderbilt Law School Faculty Publications

This article, written for a symposium on "Criminal Law and the Excuses," defends the "Integrationist" approach to analysis of the exculpatory effect of mental disability that I developed in Chapter Two of my book, Minding Justice: Laws that Deprive People with Mental Disability of Life and Liberty. The book argues that the special nature of the insanity defense should be reconsidered now that modern criminal law, in particular the Model Penal Code, has subjectivized affirmative defenses such as self-defense and duress for people who are not mentally ill. More specifically, the claim is that these latter defenses capture the universe …

Antibiotics, Herbs, And Magic: Health Practices In Contemporary St. Petersburg, Christine Shu

Honors Theses

In St. Petersburg, Russia, two seemingly conflicting health doctrines, western medicine and alternative medicine, play significant roles in residents' health culture. I define alternative medicine as all health practices that use such natural products as herbs, natural honey, water, seeds, berries, and even animal products, and as such unobtrusive body therapies as acupuncture, massage, yoga, or animal therapies. I define western medicine as all treatments that involve the manipulation of ingredients in a chemistry laboratory (such as antibiotics, antiviral drugs, antihistamines. or pain killers) and all body therapies intrusive to the body (such as operations). Through interviews with St. Petersburg …

Reelin Signaling Promotes Radial Glia Maturation And Neurogenesis, Serene Keilani

Electronic Theses and Dissertations

The end of neurogenesis in the human brain is marked by the transformation of the neural progenitors, the radial glial cells, into astrocytes. This event coincides with the reduction of Reelin expression, a glycoprotein that regulates neuronal migration in the cerebral cortex and cerebellum. A recent study showed that the dentate gyrus of the adult reeler mice, with homozygous mutation in the RELIN gene, have reduced neurogenesis relative to the wild type. Based on the above findings, our first hypothesis states that Reelin expression is important for the formation of radial glia and the generation of neurons from the neural …

Vesicle Targeting In Plasmodium Falciparum: The Identification And Molecular Characterization Of Plasmodium Falciparum Family Of Of Snare Proteins, Lawrence Sumanjah Ayong

Electronic Theses and Dissertations

Proteins of the SNARE (Soluble N-ethylmaleimide sensitive factor attachment protein receptor) super-family have been characterized as playing an essential role in vesicle targeting and fusion in all eukaryotes. The intracellular malaria parasite Plasmodium falciparum exhibits an unusual endomembrane system that is characterized by an unstacked Golgi apparatus, a developmentally induced apical complex, and various organellar structures of parasite origin in the infected host cells. How malaria parasites target nuclear-encoded proteins to these novel compartments is a central question in Plasmodium cell biology. Ultrastructural studies elsewhere have implicated the participation of specialized vesicular elements in transport of virulence proteins, including various …

Group-Conflict Resolution: Sources Of Resistance To Reconciliation, Erin O'Connor

Vanderbilt Law School Faculty Publications

In the past few years a number of scholars in a variety of intellectual disciplines have contributed to a better understanding of dyadic conflicts and their resolution. In particular, sociologists, psychologists, anthropologists, lawyers, and others have explored the dynamics of apology and its role in deescalating disputes and promoting forgiveness and reconciliation. Furthermore, we have a better understanding today of the benefits to individuals from forgiveness and reconciliation. Victims who are able to forgive their transgressors have better psychological and physical health and lead richer lives. Because lawyers tend to focus their attentions on legal disputes, a growing body of …

In Family Law, Love's Got A Lot To Do With It: A Response To Philip Shaver, Terry A. Maroney

Vanderbilt Law School Faculty Publications

In a contribution to this Symposium on Law and Emotion: Re-Envisioning Family Law, Phillip Shaver and his co-authors succinctly encapsulate contemporary psychological theory on interpersonal attachment -- primarily parent-child attachment and its role in creating lifelong attachment patterns -- and seek to outline the relevance of such research for both social policy and law. This Comment demonstrates that many areas of family law already seek to cultivate and reward attachment. But attachment is not and cannot be the sole-or even, perhaps, the most important-factor driving most legal determinations. Recognizing the importance of secure attachment does not answer difficult questions about …

Beyond Public Health : The Cultural Politics Of Tobacco Control In Hong Kong, Wai Yin Chan

Lingnan Theses

This work provides cultural and political explanations on how and why cigarette smoking has increasingly become an object of intolerance and control in Hong Kong. Since the 1980s, the smoking population has been falling. Smoking behavior, sales and promotion of cigarette products have been under close surveillance by the government, medical experts and society at large. Cigarette smoking, as well as smokers, has increasingly been rejected and demonized in the public discourse. What are the conditions that make the growing intolerant discourses and practices against cigarette smoking possible and dominant? Why and how has the tobacco control campaign become prevalent …

Queering Sex Machines : The Re-Articulation Of Non-Normative Sexualities And Technosexual Bodies, Hok Bun, Isaac Leung

Lingnan Theses

From the simple electronic vibrator to the complex assemblages of cybersex, sex and technology have always intersected. The dynamic relations between sexuality and technology are constantly changing along with the ways in which human beings achieve psychological and bodily pleasure through these devices. Sex machine, a term that denotes an automated device that can assist human in the pursuits of sex, has been broadly defined as therapeutic and pleasure machines in the West. Large numbers of sex machines have been documented in Europe and America starting from the nineteenth century, and were widely produced and utilized by medical practitioners, sex …

Ethical Problems In Connection With World Poverty, Wing Fan

Lingnan Theses

World economy has been doing well in recent decades even taking into account the current financial crisis. However, there are even more people suffering from poverty and related issues than earlier. I am going to discuss the issue of helping poor people in the context of ethics.

In my thesis, I will firstly state the standard of absolute poverty, which will be the main focus in the remainder of the text. Then, I will present the argument given by a contemporary philosopher, Peter Singer, that urges us to give money to the poor people. I will go through his argument …

Can Clinical Genetics Laboratories Be Sued For Medical Malpractice?, Ellen Wright Clayton, Alexandra L. Foulkes, Jessica L. Roberts, Et Al.

Vanderbilt Law School Faculty Publications

From a legal perspective, is a clinical laboratory a healthcare provider? Physicians are clearly healthcare providers who owe their patients the associated fiduciary duties. It is less clear, however, which-if any-legal duties genetic testing labs owe to the individuals who seek their services.

The question of whether clinical genetics laboratories are healthcare providers for legal purposes may be thornier than it could initially appear. Clinical genetics laboratories perform multiple tasks. Most significantly, they sequence genetic samples and then interpret the results. As "next generation sequencing" has become more accessible,' labs can generate and interpret more sequence data for a growing …

Cohort Study Of Pain Behaviors In The Elderly Residing In Skilled Nursing Care, Allison Burfield

Electronic Theses and Dissertations

An integral concern across care settings is the prompt intervention for patients suffering with pain. Long-term care (LTC) settings present with unique challenges to assess and manage pain in resident populations. Pain assessment is especially challenging, because residents have varying degrees of cognition to communicate their pain, and clinician/staff knowledge of pain symptoms may be lacking. The purpose of this research was to improve the measurement of pain and outcomes of care for the elderly residing in skilled nursing care, especially those with cognitive-impairment. The specific aims of this study were to: 1) Determine the magnitude of the relationship between …

Effects Of An Evidence-Based Intervention On Stress And Coping Of Families Of Critically Ill Trauma Patients, Sandra Knapp

Electronic Theses and Dissertations

Problem/Purpose: Critical care nurses are frequently exposed to the stress experienced by their patients' families, yet they often do not have the knowledge or skills to help family members cope with the stress of critical illness. While needs and stressors of families of the critically ill have been researched extensively, no prior studies have been conducted to determine the effects of an evidence-based nursing intervention for reducing family members' stress and improving their coping skills. The purpose of this study was to determine if an evidence-based nursing intervention designed to address the needs of family members would reduce stress and …

Pubs, Punters, And Pints: Anthropological Reflections On Pub Life In Ireland, Jason Cucchiara

Electronic Theses and Dissertations

Ireland is a country with a rich and unique cultural heritage. It is difficult to imagine that certain facets of Irish culture (e.g. Saint Patrick's Day, the Blarney Stone, or the Ring of Kerry) can ever be taken for granted since they are so widely recognized internationally. One common feature of Irish life that possibly warrants more scholarly attention is the public house or pub. Much has been written about pubs as quaint institutions in popular literature and fiction. Curiously, they remain largely overlooked as vital aspects of Irish culture by anthropologists and others in the social sciences. In many …

Geophysical Survey Of Greenwood Cemetery, Orlando, Florida, Dennis Wardlaw

Electronic Theses and Dissertations

Advances in geophysical and remote sensing technology, specifically with ground penetrating radar (GPR) and geographic information systems (GIS), have led to increased use for archaeological research within cemeteries. Because of its non-invasive manner and high resolution of subsurface anomalies, GPR is ideal for surveying areas with marked or unmarked graves within cemeteries. Using a GIS assists cemetery research by facilitating integration of datasets and projection of spatial data. What has not been attempted to this point is systematic attempting to correlate detection rates of marked graves using a GPR with the time frame of the grave while incorporating the data …

Categorical Perception Of Stop Consonants In Children With Autism, Laura Bourdeau

Electronic Theses and Dissertations

The purpose of this study is to determine whether children with autism recognize the same perceptual voicing boundaries of stop consonants as normally developing children of the same age group. This was explored using three groups of participants: ten children with autism between the ages of 8-14, five typically developing children between the ages of 8-14, and five typically developing seven-year-old children. Children in all groups listened to initial stop consonant syllables with voicing contrasts, with voiced and voiceless cognates presented. The initial consonants were altered along a voice onset time continuum within the typically perceived boundaries of each consonant. …

A Model Of Treating Hyperfunctional Voice Disorders For School Age Children Within A Serious Gaming Environment, Suzanne King

Electronic Theses and Dissertations

The purpose of the present study is to test the feasibility of implementing a video-game based intervention protocol as a means to improve therapy compliance in school age children with hyperfunctional voice disorders. Three levels of modification were made to an existing entertainment software program in order to implement the therapeutic protocol and test compatibility. The third level of modification included a two-phase quasi-experimental single subject design with a school age participant receiving the video game therapy protocol and traditional therapy for equal time. The independent variables for this study included the mode of voice therapy delivery (traditional vs. video …

Selling Sunshine: How Cypress Gardens Defined Florida, 1935-2004, David Dinocola

Electronic Theses and Dissertations

This thesis examines the relationship between Cypress Gardens and the state of Florida. Specifically, it focuses on how the creator of the park, Dick Pope, created his park after his own idealized vision of the state, and how he then promoted both his park and Florida as one and the same. The growth and later decline of Cypress Gardens follows trends in Florida's growth patterns and shifts in tourism. This study primarily uses a combination of newspaper sources and promotional pictures and other media from the park to explain how Pope attempted to make Cypress Gardens synonymous with Florida. In …

Post-Apartheid Political Culture In South Africa, 1994-2004, Andrew Kinsell

Electronic Theses and Dissertations

Between 1994 and 2004 the African National Congress (ANC) dominated government at every level of every branch. As a result, the checks and balances that are a necessary part of any democracy were non-existent. Understanding the powerful position they occupied, the ANC increasingly acted on its own accordance without any regard for the wishes of the South African populace. This lack of public consideration, coupled with the failure to economically redistribute wealth among the vast unemployed majority, turned an optimistic political culture with mass participation in 1994 into a disillusioned political culture with reduced political participation in 2004. These economic …

The Effectiveness Of Post-Secondary Web Based Communication In The University Of Central Florida's Online Educational Settin, Brandon Hinchman

Electronic Theses and Dissertations

While technology continues to advance, so do methods of learning. In post-secondary education during the twentieth century, the traditional classroom setting was geared toward auditory instruction and face-to-face peer interaction. Not only was this the most efficient means of instruction for the time period but the only means. Along with the advent of communication technology came the concept of Web courses. Web courses have expanded the means by which students can experience course lectures and have beckoned the use of updated media by which such lectures can take place. Such media include threaded discussions, chat rooms and e-mail. At the …

India And China Space Programs: From Genesis Of Space Technologies To Major Space Programs And What That Means For The Internati, Gaurav Bhola

Electronic Theses and Dissertations

The Indian and Chinese space programs have evolved into technologically advanced vehicles of national prestige and international competition for developed nations. The programs continue to evolve with impetus that India and China will have the same space capabilities as the United States with in the coming years. This will present new challenges to the international community in spheres civilian, to space and military applications and their residual benefits.