Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Life Sciences (2582)
- Physical Sciences and Mathematics (1596)
- Social and Behavioral Sciences (1461)
- Medicine and Health Sciences (1293)
- Education (1163)
-
- Law (1090)
- Arts and Humanities (953)
- Engineering (769)
- Biology (647)
- Environmental Sciences (542)
- Higher Education (431)
- Animal Sciences (378)
- Plant Sciences (374)
- Ecology and Evolutionary Biology (330)
- History (320)
- Chemistry (312)
- Communication (286)
- Psychology (286)
- Medical Sciences (261)
- Medical Specialties (223)
- Biochemistry, Biophysics, and Structural Biology (210)
- Library and Information Science (206)
- American Studies (202)
- Marine Biology (181)
- Sociology (177)
- Public Health (172)
- Earth Sciences (169)
- Business (167)
- Science and Mathematics Education (167)
- Computer Sciences (166)
- Institution
-
- University of Nebraska - Lincoln (1437)
- University of South Florida (488)
- Louisiana State University (343)
- Brigham Young University (286)
- University of Montana (283)
-
- California Polytechnic State University, San Luis Obispo (274)
- Washington University School of Medicine (255)
- Utah State University (248)
- University of Central Florida (230)
- Clemson University (221)
- Nova Southeastern University (214)
- University of New Hampshire (206)
- Eastern Illinois University (198)
- TÜBİTAK (195)
- University of New Mexico (179)
- Southern Illinois University Carbondale (174)
- University of Alabama at Birmingham (174)
- University of North Dakota (168)
- University of Nevada, Las Vegas (161)
- Stony Brook University (158)
- University of Kentucky (154)
- Virginia Commonwealth University (153)
- San Jose State University (142)
- West Virginia University (131)
- Wright State University (131)
- Old Dominion University (127)
- University of Mississippi (126)
- University of Rhode Island (126)
- Bowling Green State University (120)
- Mississippi State University (119)
- Keyword
-
- Newspaper (178)
- Humans (133)
- Animals (119)
- Newsletter (107)
- Bowling Green State University (95)
-
- 2008 (92)
- Student newspapers (81)
- Biology (79)
- Education (79)
- EIU (75)
- Future (70)
- 2008(Vol.40) (68)
- Central Florida Future (68)
- Faculty (65)
- Eastern Illinois University (64)
- Science (64)
- B.G. News (63)
- BG News (63)
- Daily Eastern News (63)
- Genetics (58)
- Female (57)
- History (56)
- Male (56)
- Agriculture (55)
- Mice (54)
- Course catalog (52)
- Ecology (51)
- Press release; media release; press statement; news media information (50)
- Student (50)
- Climate change (46)
- Publication
-
- Theses and Dissertations (455)
- Faculty Publications (315)
- Electronic Theses and Dissertations (237)
- USF Tampa Graduate Theses and Dissertations (186)
- Open Access Publications (168)
-
- All ETDs from UAB (119)
- Graduate Theses, Dissertations, and Problem Reports (ETD) (108)
- Stony Brook Theses and Dissertations Collection, 2006-2020 (closed to submissions) (107)
- Faculty Scholarship (106)
- Dissertations (104)
- LSU Doctoral Dissertations (103)
- Theses (100)
- All Graduate Theses and Dissertations, Spring 1920 to Summer 2023 (94)
- Nebraska Tractor Tests (92)
- United States Department of Agriculture-Agricultural Research Service / University of Nebraska-Lincoln: Faculty Publications (91)
- Saudi Medical Journal (86)
- Open Access Dissertations (82)
- Ethnobotanical Leaflets (81)
- Graduate Student Theses, Dissertations, & Professional Papers (80)
- Articles (79)
- Masters Theses (77)
- All Theses (75)
- International Congress on Environmental Modelling and Software (72)
- LSU Master's Theses (71)
- Central Florida Future (68)
- UNLV Retrospective Theses & Dissertations (67)
- Master's Theses (66)
- Western North American Naturalist (66)
- Cal Poly Student Newspaper (65)
- Undergraduate Student Symposium (65)
- Publication Type
- File Type
Articles 14971 - 15000 of 15504
Full-Text Articles in Entire DC Network
Enhancement Of Bonding To Enamel And Dentin Prepared By Er,Cr:Ysgg Laser, Ali Obeidi
Enhancement Of Bonding To Enamel And Dentin Prepared By Er,Cr:Ysgg Laser, Ali Obeidi
All ETDs from UAB
No abstract provided.
Modulation Of Lipoprotein Metbolism And Atherosclerosis By The G Protein-Coupled Receptor, G2a, Brian W. Parks
Modulation Of Lipoprotein Metbolism And Atherosclerosis By The G Protein-Coupled Receptor, G2a, Brian W. Parks
All ETDs from UAB
No abstract provided.
The Role Of Neighborhood Residency In The Decision To Evacuate, Naya S. Mcmillan
The Role Of Neighborhood Residency In The Decision To Evacuate, Naya S. Mcmillan
All ETDs from UAB
No abstract provided.
Biomimetic Self-Assembled Nanomatrix For Drug Eluting Stent Application, Meenakshi Kushwaha
Biomimetic Self-Assembled Nanomatrix For Drug Eluting Stent Application, Meenakshi Kushwaha
All ETDs from UAB
No abstract provided.
The Role Of Centaurins In Vesicular Trafficking And Neuronal Differentiation, Jennifer Lynn Larimore
The Role Of Centaurins In Vesicular Trafficking And Neuronal Differentiation, Jennifer Lynn Larimore
All ETDs from UAB
No abstract provided.
Human Leukocyte Antigen Supertypes In Relation To Human Immunodeficiency Virus Infection Among Populations Of African Ancestry, Aleksandr Lazaryan
Human Leukocyte Antigen Supertypes In Relation To Human Immunodeficiency Virus Infection Among Populations Of African Ancestry, Aleksandr Lazaryan
All ETDs from UAB
No abstract provided.
Progression Through The Cell Cycle Is Regulated By Dynamic Chloride Dependent Changes In Cell Volumes, Christa Whelan Habela
Progression Through The Cell Cycle Is Regulated By Dynamic Chloride Dependent Changes In Cell Volumes, Christa Whelan Habela
All ETDs from UAB
No abstract provided.
The Relationship Of Adolescent Cognitive Ability To Adult Physical Health: Socioeconomic Status And Health Behavior As Mediating Variables, Timothy M. Hale
The Relationship Of Adolescent Cognitive Ability To Adult Physical Health: Socioeconomic Status And Health Behavior As Mediating Variables, Timothy M. Hale
All ETDs from UAB
No abstract provided.
Regulation Of Tau Functions By Posttranslational Modifications Of Tau And Histone Deacetylase 6, Huiping Ding
Regulation Of Tau Functions By Posttranslational Modifications Of Tau And Histone Deacetylase 6, Huiping Ding
All ETDs from UAB
Alzheimer’s disease (AD), the most common neurodegenerative disease, is pathologically characterized by senile plaques composed of amyloid β peptide and neurofibrillary tangles composed of hyperphosphorylated and aberrantly cleaved microtubule-associated protein tau. Numerous studies have demonstrated the critical importance of tau in AD pathogenesis; however, the mechanisms involved in the regulation of tau functions by posttranslational modifications of tau and by other cellular factors need to be further elucidated. The first part of my study focused on how posttranslational modifications of tau, specifically, site-specific phosphorylation and C-terminal cleavage, regulate its physiological function in associating with cytoskeleton, binding to and stabilizing microtubules …
Free -Knot Splines And Bootstrapping For Nonlinear Modeling In Complex Samples, Scott W. Keith
Free -Knot Splines And Bootstrapping For Nonlinear Modeling In Complex Samples, Scott W. Keith
All ETDs from UAB
Studies on body mass index (BMI) as it relates to headache or mortality have noted considerable nonlinearity. Approaches to rigorously analyzing these relationships have been limited to generalized linear models and survival models using either categorizations or polynomials of BMI. I have designed, evaluated, and implemented a piecewise linear logistic regression framework for modeling nonlinearity between a binary outcome and a continuous predictor, such as BMI, adjusted for covariates in complex samples. Least squares and maximum likelihood estimation methods were used to numerically optimize free-knot splines. Inference methods utilized both parametric and nonparametric bootstrapping. Parameter estimates were structured for interpretability …
High Field Functional Magnetic Resonance Imaging In The Awake, Behaving Primate: Cortical Networks Involved In Vergence Eye Movements, Matthew K. Ward
High Field Functional Magnetic Resonance Imaging In The Awake, Behaving Primate: Cortical Networks Involved In Vergence Eye Movements, Matthew K. Ward
All ETDs from UAB
Animals with eyes positioned towards the front of the head are capable of making saccadic and smooth pursuit eye movements to fixate an object at a given distance. These eye movements are conjugate (i.e. both eyes move the same amount in the same direction). To fixate objects at different distances, such animals are also capable of making vergence eye movements in which both eyes move the same amount in opposite directions i.e. disconjugately. While purely conjugate or vergence eye movements rarely occur in daily life, it is useful to study these types of eye movements separately due to the relative …
A Dual-Action, Armed Replicating Adenovirus For The Treatment Of Bone Metastases Of Breast Cancer, James Joseph Cody
A Dual-Action, Armed Replicating Adenovirus For The Treatment Of Bone Metastases Of Breast Cancer, James Joseph Cody
All ETDs from UAB
Most patients with advanced breast cancer develop osteolytic bone metastases, which have numerous complications. Because current therapies are not curative, new treatments are needed. Conditionally replicating adenoviruses (CRAds) are anti-cancer agents designed to infect and lyse tumor cells. For increased efficacy, CRAds have been armed with therapeutic transgenes. Osteoprotegerin (OPG), an inhibitor of osteoclastic bone resorption, represents a promising candidate with which to arm a CRAd intended to treat osteolytic bone metastases. We hypothesize that a CRAd armed with OPG will inhibit breast cancer bone metastasis and reduce tumor burden in the bone by directly lysing tumor cells and by …
Mesenchymal Stem Cell Interaction With Nanostructured Biomaterials For Orthopaedic Applications, William Charles Clem
Mesenchymal Stem Cell Interaction With Nanostructured Biomaterials For Orthopaedic Applications, William Charles Clem
All ETDs from UAB
Orthopaedic implants fail when bone loss around the anchoring region of the prosthesis causes the components to loosen. A revision surgery is needed to replace worn components, and bone grafting is often required to fill the void caused by osteolysis. A solution for the problem of osteolysis may be the improvement of wear resistance at the articulating surfaces by substituting materials with greater hardness. This dissertation describes two strategies for increasing the surface hardness of titanium alloy (Ti-6Al-4V) implants, without increasing surface roughness or compromising osseointegration. The first strategy utilizes microwave plasma to induce titanium nitride formation by nitrogen diffusion. …
Thrombospondin Type-1 Repeats And Their Potential Role In Inhibiting Glioblastoma Angiogenesis, Joshua C. Anderson
Thrombospondin Type-1 Repeats And Their Potential Role In Inhibiting Glioblastoma Angiogenesis, Joshua C. Anderson
All ETDs from UAB
Thrombospondin-1 (TSP-1) is a 420 kilodalton homotrimeric protein; it is one of the first identified anti-angiogenic proteins found to be expressed in some normal tissues. Peptides derived from the type-1 repeat (TSR) domains of full length TSP-1 have been shown to have anti-angiogenic activity, and thus anti-tumor activity in some non-glioma tumor models. I hypothesized that peptides derived from the TSRs of TSP-1, such as ABT-510, could inhibit angiogenesis and thus malignant glioma tumor growth in vivo. I found that ABT-510 inhibited angiogenesis of the human brain microvascular endothelial cell (MvEC) in an in vitro tubulomorphogenesis assay. To determine the …
Metabolism Of Neutrophil-Deprived Chlorinated Isoflavones, Tracy Lyn D'Alessandro
Metabolism Of Neutrophil-Deprived Chlorinated Isoflavones, Tracy Lyn D'Alessandro
All ETDs from UAB
Despite medical advances in both drug therapy and surgical techniques, Americans mostly die from heart disease. Many belong to the low- and middle-class families who do not have sufficient access to medical care due to its high costs. An alternative is the development of healthier lifestyles such as diet which may play a positive role in chronic disease management. Epidemiological and migratory studies suggest that soy plays a pivotal role in the decreased incidence of heart disease in East Asian countries, such as China, Japan, and Korea. The role of soy in cardiovascular disease progression has been the subject of …
Perception Of Motion-In-Depth: Induced Motion Effects On Monocular And Binocular Cues, John Eric Gampher
Perception Of Motion-In-Depth: Induced Motion Effects On Monocular And Binocular Cues, John Eric Gampher
All ETDs from UAB
Three cues are available to the visual system to determine motion: image displacement across the retina (retinal slip), eye movements, and configuration changes within a scene (Becklen and Wallach, 1985). Any one may lead to the false perception of motion. Induced motion is the illusory movement of one object (or objects) as a result of other movement in the visual field. A wide variety of displays have been used to study induced motion, leading to apparently different classes of induced motion. Current theories of induced motion can be categorized based on local motion, global motion, eye movement suppression, and cognitive …
Gender Difference In Cardiovascular Risk Indicator And Cardiovascular Disease Among Veterans With Ptsd, Elizabeth Frazier
Gender Difference In Cardiovascular Risk Indicator And Cardiovascular Disease Among Veterans With Ptsd, Elizabeth Frazier
All ETDs from UAB
Using the allostatic load model of disease processes, this study investigated gender differences on cardiovascular risk and cardiovascular disease among PTSD and MDD veterans. Cross-sectional analysis of 884 de-identified veteran's data from four VISN7 primary care clinics was completed via ANCOVAs and binary logistic regression analyses. Veterans with PTSD had significantly higher levels of SBP. Among female veterans without PTSD, MDD was associated with increased DBP. Among veterans with neither PTSD nor MDD, male veterans had higher levels of DBP. Veterans without PTSD and men had higher rates of cardiovascular disease. Study results support continued focus on gender differences in …
The Effects Of Maternal Prenatal Insults On The Bmi Growth Trajectory Of Children Between The Ages Of 5-12 Years, Anthony Goudie
The Effects Of Maternal Prenatal Insults On The Bmi Growth Trajectory Of Children Between The Ages Of 5-12 Years, Anthony Goudie
All ETDs from UAB
The level of childhood obesity in the United States is at epidemic proportions. Most population studies looking at the factors contributing to childhood obesity focus on obesity as a dichotomous outcome. The purpose of this study is to test for the effects of maternal prenatal insult behaviors on the growth trajectory of a sample of children 5-12 years of age in the United States. This is the first known study to use a latent growth curve model and a cohort-concurrent analytical design to test the association between maternal prenatal insult behaviors and the annual longitudinal increase in body mass index …
Growth Hormone Signaling And Action In Osteoblasts, Douglas J. Digirolamo
Growth Hormone Signaling And Action In Osteoblasts, Douglas J. Digirolamo
All ETDs from UAB
Growth hormone (GH) and insulin-like growth factor-1 (IGF-1) exert profound growth promoting actions during pre- and post-natal skeletal development. GH and IGF- 1 appear to cause these anabolic actions by influencing a variety of effects on osteoblast proliferation, differentiation, and survival. However, because GH stimulates the production of IGF-1 from the liver and other GH-responsive peripheral tissues, including bone, the individual contributions of these two molecules to anabolic responses in bone remains poorly defined. In this dissertation research, I sought to distinguish the direct and indirect (IGF-1 dependent) GH actions on osteoblasts. In the first section of this thesis, I …
Effects Of Aerobic Exercise On The Asthmatic Lung, Matthew M. Hewitt
Effects Of Aerobic Exercise On The Asthmatic Lung, Matthew M. Hewitt
All ETDs from UAB
Asthma is identified by the clinical symptoms of wheezing, chest tightness, dyspnea and cough, and by the presence of airway hyperresponsiveness (AHR) to inhaled stimuli. We have reported previously that repeated bouts of moderate intensity aerobic exercise attenuate airway inflammatory responses in a mouse model of atopic asthma. Because the effects of exercise on physiological responses are dependent upon several variables, including total exercise duration, the hypothesis of the current work was that differing amounts of moderate intensity aerobic exercise exert dissimilar effects on AHR and airway inflammation. The aims to test this hypothesis included: 1) determine the effect of …
Functionalizing Hydroxyapatite Biomaterials With Biomimetic Peptides Of Integrin Ligands, Kristin Marie Hennessy
Functionalizing Hydroxyapatite Biomaterials With Biomimetic Peptides Of Integrin Ligands, Kristin Marie Hennessy
All ETDs from UAB
Hydroxyapatite (HA) coatings of hard tissue implants have been shown to increase osseointegration, but the mechanisms by which HA improves implant integration are not well understood. Numerous studies have shown that modifying HA with adhesive peptides, including RGD, and the collagen I mimetics, DGEA and P15, stimulates the adhesion of mesenchymal stem cells (MSCs), a cell type that differentiates along the osteoblast lineage. However, HA is a highly adsorptive biomaterial, and therefore it is unlikely that cells at the implant site would ever encounter a peptidemodified HA surface in the absence of an adsorbed protein layer. In fact, our laboratory …
Molecular Regulation Of Pax5-Mediated Biological Functions, Ti He
Molecular Regulation Of Pax5-Mediated Biological Functions, Ti He
All ETDs from UAB
B lineage cells are major players in the adaptive immune system. Pax5 is essential for B lineage cell development and function. Pax5 controls B lineage cell developmental progression by regulating expression of many B lineage specific genes and the B lineage specific VH to DJH recombination; and the meantime, Pax5 also represses the transcription of lineage- and developmental stage- inappropriate genes to restrict the B lineage developmental pathway. It is not clear how Pax5-mediated function can be regulated to fulfill its role in different biological reactions. In this dissertation, we focused on the study of the molecular regulation of Pax5-mediated …
Using Rna Interference To Study The Function Of The Tethering Protein P115 In Er-Golgi Traffic, Robert Grabski
Using Rna Interference To Study The Function Of The Tethering Protein P115 In Er-Golgi Traffic, Robert Grabski
All ETDs from UAB
Metazoan cells are characterized with elaborate network of intracellular membranous compartments. These membranes allow the cell to spatially separate antagonistic processes and environments, and maintain sequential order of reactions necessary for maturation and secretion of biosynthetic cargo. The core transport machinery consists of coat proteins, tethering factors, SNAREs and small Ras-like GTPases. We have explored the function of the tethering factor p115 in organellogenesis and in secretory traffic. The p115-depleted system was utilized to explore structurefunction relationships within p115. Here, we analyzed the architecture of the Golgi after RNAi induced depletion of p115. We show that in p115 depleted cells …
Mechanism Of The Cross Talk Between Growth Hormone Receptor And Epidermal Growth Factor Receptor, Xin Li
Mechanism Of The Cross Talk Between Growth Hormone Receptor And Epidermal Growth Factor Receptor, Xin Li
All ETDs from UAB
EGF receptor (EGFR) is a receptor tyrosine kinase, mediating cell growth from ectodermal and mesodermal origin. The overexpression and aberrant function of EGFR are involved in a wide range of human carcinomas. Growth hormone receptor (GHR) coexists with EGFR in various cell types and implicated in malignant tumor behavior. Previously in our lab, we found that via ERK activation GH can threonine phosphorylate EGFR and reduce EGF-induced EGFR downregulation. GH also synergizes with EGF in activating ERK. In this project, using reconstitution, we studied the mutation of the ERK phosphorylation consensus residue on EGFR, 669T. CHO-GHR cells, which lack EGFR …
Function Of Human Retinol Dehydrogenase 12 (Rdh12) In Retinoid Metabolism, Seung-Ah Lee
Function Of Human Retinol Dehydrogenase 12 (Rdh12) In Retinoid Metabolism, Seung-Ah Lee
All ETDs from UAB
Retinol dehydrogenase 12 (RDH12) is a member of the microsomal short-chain dehydrogenase/reductase superfamily of proteins that is highly expressed in photorecep-tor cells. Mutations in RDH12 are associated with severe early-onset autosomal recessive retinal dystrophy, leading to legal blindness. Disease-associated RDH12 variants exhibit lower protein levels when expressed in eukaryotic cells. However, the physiological role of RDH12 remains unclear. As established previously, RDH12 recognizes both retinoids and lipid peroxidation products (medium-chain aldehydes) as substrates and exhibits the highest catalytic efficiency for all-trans-retinaldehyde. As the main goal of this dissertation, we characterized the catalytic properties of RDH12 and its naturally occurring mutants …
The Role Of Strychnine-Sensitive Nachrs In Rabbit Retinal Off Ganglion Cells, Jordan Michael Renna
The Role Of Strychnine-Sensitive Nachrs In Rabbit Retinal Off Ganglion Cells, Jordan Michael Renna
All ETDs from UAB
that when heteroskedasticity is present, but ignored, there is significant evidence to suggest
Changes In Hippocampal Excitability During Withdrawal From Chronic Nicotine, Rachel E. Penton
Changes In Hippocampal Excitability During Withdrawal From Chronic Nicotine, Rachel E. Penton
All ETDs from UAB
seeking behavior following chronic drug use lasts for many months or even years. Short-term withdrawal experiments have suggested that the neuroadaptations thought to underlie learning and memory may also contribute to addictive behavior. However, there is little information about the physiological mechanisms that participate in craving and relapse following long-term withdrawal. Here I show in hippocampal slices from rats treated with nicotine for 1 week that there is a change in the excitability of CA1 pyramidal cells that persists for up to 9 months following the cessation of drug treatment. The expression of this enhanced excitability is dependent on different …
Wavelet-Based Regression And Classification For Longitudinal Diffusion Tensor Imaging Data, William R. Prucka
Wavelet-Based Regression And Classification For Longitudinal Diffusion Tensor Imaging Data, William R. Prucka
All ETDs from UAB
Diffusion tensor imaging (DTI) is a magnetic resonance imaging (MRI) technique capable of in vivo characterization of the spatial and angular dependence of free water diffusion in tissue. By studying intra- and extra-cellular water mobility, inference can be made about the surrounding medium. The non-uniform angular dependence of diffusion, known as anisotropy, is evident in fibrous tissues, which exhibit greater diffusion parallel versus perpendicular to the fiber orientation. DTI’s sensitivity to anisotropy makes it an effective tool for measuring the integrity of fibrous myelinated white matter tracts in the brain. For demyelinating diseases such as multiple sclerosis (MS), DTI has …
Characterizing Semantic Memory In Mild Cognitive Impairment, Kelli L. Netson
Characterizing Semantic Memory In Mild Cognitive Impairment, Kelli L. Netson
All ETDs from UAB
Episodic memory is clearly impaired in mild cognitive impairment (MCI), although recent studies have revealed deficits in other cognitive domains such as attention, executive function, and semantic memory. Studies of semantic memory in MCI have been limited by inconsistent use of diagnostic criteria and variability in the measures used. The purpose of this study was to examine semantic memory in a sample of individuals diagnosed with amnestic MCI using Mayo criteria. Performance of individuals with consensus-diagnosed MCI (n=12) was compared to that of normal controls (n=15) on a battery of semantic memory tasks. MANOVA results indicated that the MCI group …
Adenovirus As A Platform For Assembly And Targeted Delivery Of Gold Nanoparticles To Tumor Cells, Vaibhav Saini
Adenovirus As A Platform For Assembly And Targeted Delivery Of Gold Nanoparticles To Tumor Cells, Vaibhav Saini
All ETDs from UAB
Novel combinatorial strategies need to be explored to achieve tumor eradication. In this regard, viral vector based gene therapy and nanotechnology offer unique possibilities for cancer therapy. As an example, multifunctional adenoviral (Ad) vectors capable of targeting, imaging, and successful cancer gene therapy have been advanced into multiple clinical trials. Similarly, novel multifunctional gold nanoparticles (AuNPs) have been utilized for drug delivery, targeting, imaging, and hyperthermia tumor therapy. Therefore, to accrue the benefits of both gene therapy and nanotechnology for cancer therapy, we proposed to combine Ad vectors and AuNPs in a single multifunctional nanodevice. Towards this goal, herein, we …