Digital Commons Network^™

Clinico-Pathologic Features Of Chronic Myeloid Leukemia And Risk Stratification According To Sokal Score, Naveen Naz Syed, Mikal Usman, Gulnaz Khaliq, Salman Adil, Mohammad Khurshid

Department of Pathology and Laboratory Medicine

To compile the clinical and haematological parameters of chronic myeloid leukemia (CML) and risk stratification according to Sokal score in our population. A descriptive analysis. The Aga Khan University Hospital, during the period from August 1997 to August 2005. All patients with diagnosis of chronic myeloid leukemia treated as outpatient in haematology clinic, or admitted in haem-oncology wards in The Aga Khan University Hospital were included. Records were retrospectively analyzed for clinicopathologic features. Risk groups were assigned as per Sokal scoring. During the 8 years study period, 245 patients with chronic myeloid leukemia were analyzed, the median age of presentation …

Screening For Cystic Fibrosis: The Importance Of Using The Correct Tools, Uzma Shah, Tariq Moatter

Department of Pathology and Laboratory Medicine

Background: Cystic Fibrosis (CF) is a potentially lethal genetic disorder. The most frequent mutation worldwide in the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) gene is designated as the Delta F508 mutation. This mutation was found in only 33% of Pakistani patients studied. Since the common Pakistani mutations remain to be identified, appropriate screening tools are required to identify disease. Sweat chloride determinations remain the gold standard for diagnosing CF. This study was done to emphasize the importance of using the correct tests.
Methods: The study was conducted at the Aga Khan University Hospital. The CFTR delta F508 mutation was tested …

Small B Cell Non-Hodgkins Lymphoma In Pakistan, Kanwal Aftab, Yasmin Bhurgri, Shahid Pervez

Department of Pathology and Laboratory Medicine

Objective: To study the pattern of small B cell lymphomas in Pakistan.

Methods: This descriptive study was carried out at the Aga Khan University Hospital pathology department including 1721 cases of Non-Hodgkins Lymphoma (NHL) diagnosed during a period of five years (1998-2002) and classified according to REAL/WHO classification. The antibodies used included Leukocyte Common Antigen (LCA), Pan B (CD20, CD79a), Pan T (UCHL-1), Bcl 2, Mib 1(Ki 67) and Cyclin D1 (Dako, Denmark).

Results: Out of the 1721 NHL cases, only 140 (8.1%) could be categorized as small B-cell NHL. The study group comprised small lymphocytic lymphoma/chronic lymphocytic leukemia (58 …

Autonomy And Subjugation: The Dynamics Of Emancipation And Race In The Writings Of Precolonial German Women Authors, Traci S. O'Brien

Dissertations, Theses, and Capstone Projects

This dissertation is a study of certain contradictions in texts written by three authors of the nineteenth century, Ida von Hahn-Hahn (1805-1880), Fanny Lewald (1811-1889) and Ottilie Assing (1819-1884). The seeming discrepancy between the general enlightenment principles of their work and their position vis-a-vis the racial Other is at the center of my exploration. My position in this dissertation is that it is not possible to discuss their emancipatory ideas separate from their racializing metaphors. In fact, such metaphors are vital to their articulation of progress and emancipation. The discursive context of precolonial Germany can in part explain the relationship …

Relationship Between Parental Physical Discipline And Child Externalizing Problems In The Caribbean Subculture In New York City, Meltem Paker

Dissertations, Theses, and Capstone Projects

This study investigated the relationship between parental physical discipline (PD) and child externalizing behaviors (EB) in the Caribbean subculture and examined whether acculturation to the European American and Caribbean cultures, generational status, normativity of PD, and warmth in the parent-child relationship moderated this relationship. Eighty-nine parents of Caribbean origin answered an anonymous survey consisting of various scales and demographic questions.

Descriptive analyses indicated that parents in this study used PD an average of 10 times during the past year. The majority (69%) reported using at least one PD act in the past year. All forms of more severe PD (e.g., …

Henry James’S "The Ambassadors": Anatomy Of Silence, Marie Leone Meyer

Dissertations, Theses, and Capstone Projects

This dissertation examines the use of silence in Henry James's novel The Ambassadors. James uses silence rich in meaning to portray the protagonist Lewis Lambert Strether's unfolding consciousness. James creates different types of silences that reflect a shift from the spoken or written word to alternate symbol systems. James's novel perches on the threshold of modernity, as his work reflects the ideas of a line of thinkers extending back from James and his brother, William, to Ralph Waldo Emerson, Sampson Reed, and Emanuel Swedenborg. At the same time, the novel draws on the contemporary ideas of Charles Darwin, prefigures …

Demographic Issues In Infant Health In The 1990’S And Measurement Issues In Costing Medicaid Expansions, Danielle H. Ferry

Dissertations, Theses, and Capstone Projects

National measures of infant health in the 1990s were flat, but rates of low birth weight and preterm birth among blacks, especially in center cities, improved. Health gains were especially marked in Washington, DC. Analysis at the metropolitan area level reveals that center city-suburban gaps in black infant health declined. The first two chapters of this dissertation use the 1990-2001 National Center for Health Statistics (NCHS) Natality Files to examine improvements in infant health among African-Americans, first, in Washington, DC, and second, in 37 metropolitan areas with large black populations.

Although Washington, DC also experienced substantial, above-average reductions in its …

The Technical Fix Or The Systemic Solution For Urban Water Quality? A Case Study Of Grassroots Activism On Behalf Of New York City's Drinking Water, Mirele B. Goldsmith

Dissertations, Theses, and Capstone Projects

This case study examines the activities of the Croton Watershed Clean Water Coalition from 1996 until 2004. The Coalition opposed construction of a filtration plant for the Croton water supply. The study traces the Coalition’s campaign against filtration, which took place in the context of the widely heralded New York City Watershed Memorandum of Agreement (1997). Although the Agreement permitted New York City to avoid filtration for its Catskill and Delaware water supplies, plans were laid for filtration of the Croton supply.

My study is informed by political ecology which provides a framework for understanding politics, practices and contradictions involved …

I. Comparison Of Translesion Bypass Of Guanine–N2 Monoadducts Of Mitomycin C And Guanine-N7 Monoadducts Of 2,7-Diaminomitosene By T7 Exo-, Klenow Exo-, Eta And Klenow Exo+ Dna Polymerases. Ii. Structure-Based Design, Synthesis, Structure-Conformation And Structure-Activity Relationships Studies Of D-Phe-Pro-D-Arg-P1’-Conh2 Tetrapeptides With Inhibitory Activity For Thrombin., Cristina C. Clement

Dissertations, Theses, and Capstone Projects

The guanine (G)-N² DNA monoadduct of mitomycin C (MC), a cytotoxic anticancer drug, inhibits translesion bypass by DNA polymerases. 2,7-Diaminomitosene (2,7-DAM) is the major metabolite of MC in tumor cells, generated by the reduction of MC. 2,7-DAM alkylates DNA in the cell in situ, forming an adduct at the N7 position of 2'-deoxyguanosine (2,7-DAM-dG) and is noncytotoxic. In part I of this study we tested a potential correlation between the lack of cytotoxicity of 2,7-DAM and the relative ease of bypass of this adduct as compared with the MC adduct. 24-mer and 27-mer templates, adducted at a single …

Erc Accumulation And Premature Aging: An Investigation Of The Deletion Of Ash1 In The Budding Yeast Saccharomyces Cerevisiae, Ranor C B Basa

Pomona Senior Theses

This thesis concerns the asymmetric mechanism by which the "molecular aging clock" is reset in the budding yeast Saccharomyces cerevisiae, which is of great interest considering that many organisms' cells--including human stem cells--undergo this process. When yeast divides, it ages a generation, while daughter cells begin life at generation zero. One theory surrounding this process in yeast is the extrachromosomal rDNA circle (ERC) aging theory. ERCs are generated spontaneously in mother cells as they age, and thus accumulate exponentially in older cells. Daughter cells from young mothers benefit from asymmetric aging, but as mothers age, they produce daughters that …

Yale Leaf Morphology Digitization And Network Project, David Stern

Faculty and Staff Publications – Milner Library

This article describes a digitization project inspired by the innovative leaf morphology classification work of a faculty member in the Geology and Geophysics Department and the Peabody Museum at Yale University. We began our initiative by scanning the Flora Fossilis Arctica, a 7-volume fossil leaf identification tool covering various geological areas, published between 1868 and 1883. This classic paleobotany resource was digitized, creating tiff, pdf, and searchable pdf files. We are now converting the searchable pdf files into ASCII text, enhancing the raw data with metadata elements, placing this material on the web for searching and display; and linking this …

Unnatural Selection: The Fundamentalist Crusade Against Evolution And The New Strategies To Discredit Darwin, Randall W. Hall

University of Florida Journal of Law & Public Policy

No abstract provided.

Reconceptualising Female Trafficking: The Inhuman Trade In Women, Alison Cole

Cardozo Journal of Equal Rights & Social Justice

The article argues that female trafficking must be reconceptualized under international criminal law as a crime against humanity to establish a uniform legal framework for combating this global issue. It critiques existing international approaches for lacking coherence and enforcement, emphasizing the need for a clear definition and standardized measures to address the severity of trafficking. The UN Trafficking Protocol, while authoritative, leaves significant discretion to states, resulting in varied domestic policies that hinder effective international cooperation. By classifying female trafficking as a crime against humanity, the article proposes a more robust legal basis for universal jurisdiction and individual liability, aligning …

The Sedimentary Environment Below Earth’S Polar Ice Cap As A Microbial Habitat, David C. Smith, Stephanie Forschner-Dancause, David C. Rowley, Steven D'Hondt

Graduate School of Oceanography Faculty Publications

University of Rhode Island faculty participated in drilling of the polar ice cap to study microbial diversity and adaptation to subsurface life under conditions that may mimic extraterrestrial subsurface conditions.

Nematodes In Western Australian Vineyards, Vivien Vanstone, Neil Lantzke

Bulletins 4000 -

Nematodes are worm-like microscopic animals that live in the soil. There are numerous soil-inhabiting nematode species, but not all are harmful to plants. Some nematodes are plant-parasitic, feeding on and damaging roots, including those of grapevine. Feeding activities of these nematodes reduce the vine’s ability to take up water and nutrients from the soil, leading to lack of vigour, symptoms of nutrient deficiency, wilting, lower yield, vine decline and, in severe cases, vine death. Nematode feeding sites can also lead to entry of other disease-causing organisms (e.g. fungi or bacteria), resulting in rapid vine decline.

Nematodes can survive in the …

Australian Plague Locust (Chortoicetes Terminifera), Department Of Agriculture And Food, Wa

Bulletins 4000 -

The Australian plague locust (APL) is the most economically important grasshopper in Australia. The immature hopper stage damages mainly pastures in farming areas, and gardens and lawns in domestic areas. They tend to avoid established green crops, although the edges of crops can be damaged. Adult locusts can form swarms and fly into other areas, damaging pastures, ripening cereal, lupin and pulse crops, grapevines, fruit trees and native tree seedlings. If crops have completely dried off before locusts begin flying, the possibility of damage is considerably less.

Cd 610 Moral Development, Mark Maddix

Syllabi

TEXTBOOKS Required Textbooks: James C. Wilhoit and John M. Dettoni. 1995. Nurture that is Christian: Developmental Perspectives on Christian Education. Wheaton: Victor Books. ISBN# 1564762688 James Fowler. 1996. Faithful Change: The Personal and Public Challenges of Postmodern Life. Nashville: Abingdon Press. ISBN# 0687017300 Jean Piaget. 1965. The Moral Judgment of the Child. New York, Free Press. (Out of Print-purchase used on Amazon.com) Carol Gilligan. 1993. In a Different Voice. Harvard University Press. ISBN# 0674445449 William Damon. 1988. The Moral Child: Nurturing Children’s Natural Moral Growth. New York, Free Press. ISBN# 0029069335 Recommended Reading: C.S. Lewis, The Great Divorce Reading Packet …

Cd 610 Moral Development, Chris Kiesling

Syllabi

TEXTBOOKS James C. Wilhoit and John M. Dettoni. Nurture that is Christian: Developmental Perspectives on Christian Education. Wheaton: Victor Books, 1995. James Fowler. Faithful Change: The Personal and Public Challenges of Postmodern Life. Nashville: Abingdon Press, 1996. Jean Piaget, The Moral Judgment of the Child. New York, Free Press, 1965. E Stanley Jones, The Christ of the Mount.

Transport Of Spring Floodwater From Rivers Under Ice To The Alaskan Beaufort Sea, Matthew B. Alkire, John H. Trefry

Ocean Engineering and Marine Sciences Faculty Publications

Spring floods carry Alaskan river water north to a frozen Beaufort Sea. A plume of water from the Sagavanirktok River (SR) was identified and traced by measuring salinity, d18O, and dissolved silica in discrete water samples collected beneath landfast ice in the coastal Alaskan Beaufort Sea from late May to early June 2004 during high river flow. An Optimum Multiparameter analysis was used to calculate the fractions of SR water from the measured geochemical parameters. The SR plume followed the northwestward flowing local circulation and moved ~17 km north and ~15 km west under ice from the river mouth. The …

The Legal Status Of Pregnant And Parenting Youth In Foster Care, Eve Stotland, Cynthia Godsoe

University of Florida Journal of Law & Public Policy

No abstract provided.

Progress On The Wipo Broadcasting And Webcasting Treaty, Matthew D. Asbell

Cardozo Arts & Entertainment Law Journal

No abstract provided.

Age-Related Alterations In The Dynamics Of L-Glutamate Regulation In The Striatum Of The Fischer 344 Rat, Justin Robert Nickell

University of Kentucky Doctoral Dissertations

L-glutamate is the predominant excitatory amino acid neurotransmitter inthe mammalian central nervous system. Prior aging studies have focusedprimarily on dopaminergic circuitry of the striatum, and data obtained studyingglutamate regulation in the striatum have been largely equivocal. Thesediscrepancies are due in large part to the limitations of microdialysis; while it isextremely sensitive to minute concentrations of analyte, it is lacking in terms ofthe temporal resolution necessary to study a neurotransmitter with rapid releaseand clearance kinetics such as glutamate. In order to address this matter, ourlaboratory has designed a ceramic-based multisite microelectrode with thecapability to detect and analyze fluctuations in extracellular glutamateconcentrations …

Neurochemical Studies Of Attention-Deficit/Hyperactivity Disorder Medications In The Striatum And Nucleus Accumbens Of The Fischer 344 Rat, Barry Matthew Joyce

University of Kentucky Doctoral Dissertations

Stimulant medications such as D-amphetamine, mixed-salts (75% D- and25% L-) amphetamine; Adderall®, and methylphenidate are first-line treatmentsfor Attention-Deficit/Hyperactivity Disorder (ADHD). In vivo studies havepredominantly focused on these stimulants in the context of drug abuse, andtheir therapeutic mechanistic properties are only theoretical. Previously, in vivotechniques have been limited by poor temporal and spatial resolution, andcharacterizations of these medications in rodent models have not been possibleat low, clinically relevant levels. In order to address these issues, our laboratoryused in vivo high speed chronoamperometric microelectrodes to characterize theeffects of local applications of D-amphetamine, L-amphetamine, D,Lamphetamine,and Adderall® at low levels in the striatum and …

Mrs. Rawlings, Mr. Stevens, And The Nature Of Florida, Thomas C. Harrison

The Marjorie Kinnan Rawlings Journal of Florida Literature

No abstract provided.

Sexual Punishments, Alice Ristroph

Faculty Scholarship

No abstract provided.

The History Of Slave Marriage In The United States, Darlene Goring

Journal Articles

No abstract provided.

Lady Griz Volleyball Media Guide, 2006, University Of Montana—Missoula. Athletics Department

Lady Griz Volleyball Media Guides, 1979-2008

Media guide created about the Lady Griz volleyball team.

Rational Alcohol Addiction: Evidence From The Russian Longitudinal Monitoring Survey, Badi H. Baltagi, Ingo Geishecker

Center for Policy Research

Alcohol consumption in Russia is legendary and has been reported to be the third leading cause of death in the former Soviet Union after heart disease and cancer. Are Russian alcohol consumers rational addicts? This paper uses eight rounds of a nationally representative Russian survey spanning the period 1994-2003 to estimate a rational addiction (RA) model for alcohol consumption. This is done in a panel data setting as well as on a wave by wave basis. The profile of the Russian drinker finds a huge difference between males and females and the model is estimated by gender. We do not …

University Of Central Florida Libraries, Annual Report 2005-2006, Ucf Libraries

Libraries' Documents

No abstract provided.

Behavioral Genetics Research And Criminal Dna Databanks, David H. Kaye

Faculty Scholarship

This article examines the current concerns about whether DNA databases may be used for actions other than to apprehend criminals, such as genetic research, in particular, searching for a "crime gene". Part II considers the perspective that these databases may be useful for research. The information within a DNA sample consists of a limited number of DNA base-pair variations, which are important to identification, but not necessarily to genetic research. However, while it may be difficult to conduct genetic research, it is not impossible. Part III examines state and federal database legislation. There are examples of three states' statutes and …