Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2005

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 10051 - 10080 of 10353

Full-Text Articles in Entire DC Network

Epileptogenesis Causes Long-Term Plasticity Changes In Calbindin D-28k In The Rat Pilocarpine Model Of Acquired Epilepsy, Anne Johnston Harrison Jan 2005

Epileptogenesis Causes Long-Term Plasticity Changes In Calbindin D-28k In The Rat Pilocarpine Model Of Acquired Epilepsy, Anne Johnston Harrison

Theses and Dissertations

Epilepsy is one of the most common neurological disorders, affecting more than 2% of children and 1% of adults in the U.S. Emerging research has demonstrated that calcium, as a major second messenger system, underlies many of these injury-induced plasticity changes associated with the development of epilepsy. Recent evidence has suggested that long term elevations in neuronal resting calcium levels play a role in initiating and maintaining epileptogenesis (the development of epilepsy). Collaborations between our lab and others have produced microarray data that suggests that a major calcium-binding protein, calbindin D-28k, mRNA levels are decreased in epileptic rats even up …

Go to article

Post-Juvenile Brain Development Modulates Seizure Characteristics And Diazepam Efficacy In The Rat Pilocarpine-Se Model, William H. Holbert Ii Jan 2005

Post-Juvenile Brain Development Modulates Seizure Characteristics And Diazepam Efficacy In The Rat Pilocarpine-Se Model, William H. Holbert Ii

Theses and Dissertations

These studies were completed to examine how status epilpeticus seizure characteristics are modulated during post-juvenile brain development. This may determine if postnatal age in rats is a better identifier of stages of post-juvenile brain development. The first study fully detailed the acute discrete seizure phase of the rat pilocarpine-SE model. Results for this study showed that Racine behavioral severity score, spike frequency, and seizure severity during the acute discrete seizure phase change in relation to post-juvenile brain developmental stages. The second study fully detailed early and late patterns of status epilepticus. Results for this study displayed modulation of time in …

Go to article

Acute And Chronic Effects Of Artificial Rearing On Rat Genioglossus Muscle, Wayne Allen Moore Jr. Jan 2005

Acute And Chronic Effects Of Artificial Rearing On Rat Genioglossus Muscle, Wayne Allen Moore Jr.

Theses and Dissertations

In most mammals, nutritive suckling is critical during the early neonatal period. The genioglossus (GG) muscle in rat plays an important role in protruding the tongue for efficient suckling. The purpose of this study was to examine the contractile properties and myosin heavy chain (MHC) phenotype of the GG following an early period of artificial rearing, which reduced nutritive suckling. Beginning at three days of age Sprague-Dawley rats were fed via implanted gastric cannula until postnatal day 14 (P14). At P14, artificially reared (AR) rat pups were either placed with a lactating dam until the end of the weaning period …

Go to article

Trends In Canine Lyme Disease On The Eastern Shore Of Virginia, 2000-2005, Ellen Garrett Hillyer Jan 2005

Trends In Canine Lyme Disease On The Eastern Shore Of Virginia, 2000-2005, Ellen Garrett Hillyer

Theses and Dissertations

Introduction: Lyme disease is caused by the tick-borne spirochete Borrelia burgdorferi. Research has shown that dogs can be used as sentinels for human infection of Lyme disease. The purpose of this 5-year, retrospective study was to determine if there was any evidence that the incidence of canine Lyme disease has increased between 2000 and 2005 in Accomack and Northampton counties. An increased incidence in Lyme disease in dogs may indicate an increased present or future risk of Lyme disease in humans.Methods: Cases of canine Lyme disease were identified via practice invoicing systems and dogs that received doxycycline were entered into …

Go to article

One Is Concerned Because One Is A Human Being, Sayaka Suzuki Jan 2005

One Is Concerned Because One Is A Human Being, Sayaka Suzuki

Theses and Dissertations

I am a nomad. I have not had a place to call home in almost two decades. I wander around the world searching for a place to belong, only to discover the forgotten lives and silenced voices. I have come to realize that to find a "home," I need to first create a world in which to belong to. My recent works are investigations of possibilities for another world, a world of compassion, through a critique of our current society. I create as I rediscover the forgotten histories and lives. My work captures my process of remembering and celebrating while …

Go to article

Evidence For Absence Of Latchbridge Formation In Phasic Saphenous Artery, Shaojie Han Jan 2005

Evidence For Absence Of Latchbridge Formation In Phasic Saphenous Artery, Shaojie Han

Theses and Dissertations

Tonic arterial smooth muscle can produce strong contractions indefinitely by formation of slowly cycling crossbridges (latchbridges) that maintain force at a high energy economy. To fully understand the uniqueness of mechanisms regulating tonic arterial contraction, comparisons have been made to phasic visceral smooth muscles that do not sustain high forces. This study explored mechanisms of force maintenance in a phasic artery by comparing KCl-induced contractions in the tonic, femoral artery (FA) and its primary branch, the phasic saphenous artery (SA). KCl rapidly (5 N/m2) and [ca2+]i (250 nM) in FA and SA. By 10 min, [ca2+]i declined to 175 nM …

Go to article

Delivery Of Smoke Toxicants From Cigarettes Made In Developed And Developing Countries: A Comparison Of U.S. Full Flavor And Ultra Light Brands With Syrian Cigarettes, Lynn M. Anderson Jan 2005

Delivery Of Smoke Toxicants From Cigarettes Made In Developed And Developing Countries: A Comparison Of U.S. Full Flavor And Ultra Light Brands With Syrian Cigarettes, Lynn M. Anderson

Theses and Dissertations

Clinical research is needed to understand how cigarette toxicant yield affects smoker toxicant exposure. While there is much clinical research on yield and exposure in developed countries, there is little in developing countries. Forty smokers completed one, 4-hour session to compare yield and exposure of different cigarettes. Participants smoked three cigarettes under controlled topography conditions: one U.S. 111 flavor, one U.S. ultra light, and one Syrian cigarette, with 90 minutes between cigarettes. Sessions differed by Syrian brand; 21 participants smoked Alhamraa while 19 smoked A1 Sham cigarettes. Blood nicotine and breath CO samples were obtained, HR was monitored and subjective …

Go to article

A Nomogram For Valproic Acid And The Effect Of Missed Doses, Alaa M. Ahmad Jan 2005

A Nomogram For Valproic Acid And The Effect Of Missed Doses, Alaa M. Ahmad

Theses and Dissertations

Background. Clinicians are divided on dosing recommendations when a dose is delayed or missed. For a neuropsychiatric agent like valproic acid (VPA), rational dosing recommendations are of particular importance. VPA is subject to therapeutic monitoring using total concentrations. Due to non-linear binding of VPA to plasma proteins, current dose titration schemes for VPA are empirical. The objectives of this research were to 1- study the effect of missed/delayed doses on steady state concentrations of VPA and 2-design a nomogram that can be used for dose titration based on total VPA concentrations. Methods. 1- A simulation study was conducted to test …

Go to article

The Internet World Of Fan Fiction, Melissa Jean Herzing Jan 2005

The Internet World Of Fan Fiction, Melissa Jean Herzing

Theses and Dissertations

Fan fiction, the most popular creative outlet for fans, allows the amateur writer an opportunity to be published and receive immediate feedback from peers. As educators, we can learn from the fan communities as they participate in online activities, especially fan fiction. Students are more likely to embrace entertaining and creative assignments. And since much of the world is linked to the Internet in one way or another, we can allow students an opportunity to not only improve their writing skills, but also enhance their knowledge of the Internet and its capabilities. My study included online interviews with fan fiction …

Go to article

Country Views, Rebecca Massie Jan 2005

Country Views, Rebecca Massie

Theses and Dissertations

Over the years I have created many different images and explored a variety of media along my artistic journey. Similar images continue to occur in my work - images from my life as a child and as an adult in rural settings. I lived on a poultry farm and was involved in working with my parents there. When I married, my husband was a cattle farmer so I continued to live on a farm and use rural images in my work. Living in the country makes me constantly aware of the relationship between God, nature and man. I believe that …

Go to article

Experimental Navigation And The Creative Process, Teresa A. Engle Jan 2005

Experimental Navigation And The Creative Process, Teresa A. Engle

Theses and Dissertations

For this creative project, I am exploring alternate methods of navigating urban environments, and ways in which this activity can inspire creativity. This process is intended to create a new awareness of the urban landscape, break out of the prescribed, and to inspire innovation. The range of possibilities for this way of navigating is vast, and part of the challenge of my experience has been defining boundaries, assigning variables, and using strategies for exploration – making my process inherently morphological. I hope that my work here will encourage others to step out of their comfort zone and experience their environment …

Go to article

Posthumous, Michael K. Lease Jan 2005

Posthumous, Michael K. Lease

Theses and Dissertations

This thesis reviews the background, influences, and evolution of three works that form Posthumous, an exhibit by the thesis candidate. The thesis begins with a series of vignettes that relate a number of personal experiences involving death, and photography, which have influenced the conceptual development of the work. Chapters devoted to each piece follow the vignettes. These chapters refer to the various influences that have led to the development of the following works: Obit to Self: April 10, 2005, Posthumous, and Jay. These influences range from the movie Hotel Rwanda, to handbills for punk-rock shows. The thesis ends with a …

Go to article

The Civil War: A Collaboration In Direction And Choreography, Cara E. Rawlings Jan 2005

The Civil War: A Collaboration In Direction And Choreography, Cara E. Rawlings

Theses and Dissertations

This text is a partial record of the development of the Virginia Commonwealth University production of The Civil War: A Musical that opened on April 7, 2005 for a three-week run ending April 28, 2005. The greater part of the text is devoted to the evaluation of the underlying principles of direction and choreography applied in the creation of an artistically aid financially successful production of this size. Included in the evaluation of The Civil War: A Musical are analyses of the directors' --Patti D'Beck and David Leong --individual creative processes, aesthetics, and working styles. The result of this evaluation …

Go to article

Dual Mechanism Analgesia-Enhancing Agents, Shawquia Elithia Young Jan 2005

Dual Mechanism Analgesia-Enhancing Agents, Shawquia Elithia Young

Theses and Dissertations

Currently, there is an increasing need for novel analgesics that are potent but lack undesired side effects. Recent studies have shown that both 5-HT3 receptors and α2B- adrenoceptors play a role in antinociception. MD-354, N-(3-chlorophenyl)guanidine, has a high-affinity both for 5-HT3 and α2B- adrenoceptors and could be viewed as the first example of a rather selective 5-HT3/α2B- adrenoceptor ligand. MD-354, inactive by itself, potentiates the antinociceptive effects of an inactive dose of clonidine in the mouse tail- flick assay. An attempt to determine the underlying mechanism of this potentiating effect was the purpose of the present investigation. The studies focused …

Go to article

Intracellular Ph, The Proximate Signal For Cell Volume Changes That Are Mediated By The Actin Cytoskeleton, William Pasley Jan 2005

Intracellular Ph, The Proximate Signal For Cell Volume Changes That Are Mediated By The Actin Cytoskeleton, William Pasley

Theses and Dissertations

The relationship between initial intracellular pH (pHi) and associated cell volume change was investigated by simultaneous measurement of pHi and cell volume with fluorescence imaging in polarized fungiform taste receptor cells (TRCs) loaded with BCECF in vitro. Ammonium pulses caused a brief, reversible alkalinization in pHi and induced cell swelling. Sodium-acetate pulses reversible decreased TRC pHi and induced cell shrinkage. Removal weak acids and return to Control Ringer's solution (CR) causedTRC pHi and volume to overshoot baseline levels before fully recovering. Replacing CR with zero-sodium solution resulted in irreversible acidification of TRC pHi and induced cell swelling. Addition of sodium …

Go to article

Status Epilepticus Results In A Duration-Dependent Increased Protein Kinase A Activity In The Rat Pilocarpine Model, James M. Bracey Jan 2005

Status Epilepticus Results In A Duration-Dependent Increased Protein Kinase A Activity In The Rat Pilocarpine Model, James M. Bracey

Theses and Dissertations

This study was conducted to characterize cellular changes occurring during the progression of status epilepticus (SE) that could lead to the maintenance of increased membrane excitability. SE was induced by injection of pilocarpine after which rats were monitored both electrographically and behaviorally. After various lengths of time in SE, specific brain regions were isolated for biochemical study. SE resulted in an early maintenance of PKA activity in both cortical homogenate and crude synaptoplasmic membrane (crude SPM) fractions. At subsequent stages of SE there was a significant increase in PKA activity in both homogenate and crude SPM fractions. Wester blot analysis …

Go to article

Erythrocyte-Associated Transients In Capillary Po2 In The Rat Spinotrapezius Muscle During Hemodilution With Hespan And A Hemoglobin-Based Oxygen Carrier, Matthew Barker Jan 2005

Erythrocyte-Associated Transients In Capillary Po2 In The Rat Spinotrapezius Muscle During Hemodilution With Hespan And A Hemoglobin-Based Oxygen Carrier, Matthew Barker

Theses and Dissertations

Hemoglobin-based oxygen carriers for use as transfusion fluids have emerged as a leading technology directed at stemming shortages of a safe blood supply and providing a readily available resuscitation fluid in various trauma situations. The purpose of this investigation was to determine the effects of isovolemic hemodilution with Hespan and a hemoglobin-based oxygen carrier (HBOC) on erythrocyte-associated transients (EATs) in capillary PO2. The particulate nature of blood flow in capillaries, when observed from a stationary observation point, results in fluctuations of PO2 as alternating red blood cells and plasma gaps move through the detection region. Therefore, through experimental methods which …

Go to article

Defending Defense: Circular Arguments About Artmaking, Ryan Mulligan Jan 2005

Defending Defense: Circular Arguments About Artmaking, Ryan Mulligan

Theses and Dissertations

This paper is a critical look at video and performance arts intrinsic relationship to culture. Investigations of storytelling, personal mythology, fear, and image saturation. Think-pieces on the nature of art in an entertainment society. Juggling a brief overview of various works and their relation to over arching themes of game theory, dark humor, and fascination with media. An in depth look at the process of the thesis show, "Defense is the Best Defense." Multiple takes on the thesis exhibit counterbalance the need for contemporary art to include description. This paper is a detailed look at the process of Ryan Mulligan's …

Go to article

The Unwantables: An Exploration Of Visual Narrative, Marius I. Valdes Jan 2005

The Unwantables: An Exploration Of Visual Narrative, Marius I. Valdes

Theses and Dissertations

The Unwantables is a creative project that has evolved from my lifelong interest in and relationship with visual stories. To me the most compelling aspect of visual storytelling is "imagination". The author possesses the ability to create new worlds, interesting characters, and situations that can have the potential to communicate about any topic. My project explores visual narrative as a communication tool to explain the role of imagination in my life.

Go to article

Cytokine And Chemokine Profiles In A Rat Model Of Hemorrhagic Shock After Immuno-Modulation By Androstenetriol, Kristin E. Paccione Jan 2005

Cytokine And Chemokine Profiles In A Rat Model Of Hemorrhagic Shock After Immuno-Modulation By Androstenetriol, Kristin E. Paccione

Theses and Dissertations

Further understanding of the cellular and molecular mechanisms involved in traumatic injury, and how they are modulated during drug interaction, can facilitate novel treatment strategies for future trauma patients. We hypothesize that the pharmacological agent, Androstenetriol (AET), up regulates host immune response by modulating the continued expression of mediators, including cytokines. In a double-blinded experiment, rats were hemorrhaged, driven by volume or pressure conditions, then resuscitated with fluids and packed red blood cells following a subcutaneous injection of either vehicle or drug. Blood was collected at various time points and cytokine levels were determined by analyses with both multiplex and …

Go to article

Genetic Variability, Pathogen Susceptibility, Subspecies Identity And Conservation Of The Endangered Northern Flying Squirrel (Glaucomys Sabrinus) In Virginia, James Lincoln Sparks Jr. Jan 2005

Genetic Variability, Pathogen Susceptibility, Subspecies Identity And Conservation Of The Endangered Northern Flying Squirrel (Glaucomys Sabrinus) In Virginia, James Lincoln Sparks Jr.

Theses and Dissertations

I examined the population genetic structure of three known subspecies of Glaucomys sabrinus from Appalachia, Washington State, and two previously unexamined populations from Mount Rogers National Recreation Area (MRNRA) in Southwestern Virginia. Mean FST (0.107) and an AMOVA (P G. sabrinus subspecies populations in the southern Appalachians are genetically differentiated. Glaucomys sabrinus at MRNRA were less inbred than expected. Gene flow, a consensus tree based on Nei's genetic distance, elevated heterozygosity and morphometric data suggest that the MRNRA G. sabrinus population is an intergrade of the two recognized Appalachian subspecies, G. s. fuscus and G. s. coloratus. I compared inbreeding …

Go to article

Material And Acoustic Properties Of Swimbladders Of Tilapia And Channel Catfish, Mohammed Ali Nawaz Jan 2005

Material And Acoustic Properties Of Swimbladders Of Tilapia And Channel Catfish, Mohammed Ali Nawaz

Theses and Dissertations

Acoustically, teleost swimbladders have been considered resonant underwater bubbles. Contrary results indicating that bladders are tuned less sharply than such a bubble have been explained by damping of surrounding fish tissue. Recent findings in toadfish and weakfish, however, suggest that the bladder is a highly damped structure and that the frequency of the fish sounds is deternlined as a forced response to sonic muscle movement rather than by resonance of the bladder. In this study I examined acoustics and material properties of swimbladders in Tilapia (an auditory generalist) and the channel catfish (an auditory specialist). The swimbladder was struck with …

Go to article

Overbite Correction And Smile Esthetics, Sherif Nabil Elhady Jan 2005

Overbite Correction And Smile Esthetics, Sherif Nabil Elhady

Theses and Dissertations

The purpose of this prospective clinical study was to investigate differences in outcomes from two common treatment modalities used to reduce deep overbite: maxillary incisor intrusion using an intrusion arch and posterior tooth eruption using an anterior bite plate and to assess their influence on smile esthetics. Pre-treatment and post-overbite correction records were gathered from 40 patients with deep overbite malocclusions at the Virginia Commonwealth University orthodontic clinic. Intrusion arch patients displayed significant reductions in maxillary incisor display accompanying documented incisor intrusion. Bite plate patients showed significant lower incisor intrusion and increases in the mandibular plane angle. When compared to …

Go to article

Art From Nature, Linda Jean Huffman Walker Jan 2005

Art From Nature, Linda Jean Huffman Walker

Theses and Dissertations

Seeing beauty in the simplest aspects of nature inspires me to create art as a testament to our world. Being raised on a farm in rural Virginia gave me an appreciation of a reverence for all life. The inherent forms along with color and value establish nature as the master of aesthetics. An early introduction to Japanese art showed me that all nature was worthy and significant as subjects for art. Using materials derived from nature, cotton, linen, wool, silk, adds a tactile quality that I believe elevates the enjoyment of art.

Go to article

Thalhimers Department Store: Story, History, And Theory, Elizabeth Thalhimer Smartt Jan 2005

Thalhimers Department Store: Story, History, And Theory, Elizabeth Thalhimer Smartt

Theses and Dissertations

This thesis looks at Thalhimers department store through the lenses of story, history, and theory. It first introduces the intertwining narratives of the author's paternal family and the store's history, then shares the author's personal story of Thalhimers. The second half outlines the master narrative of the American department store then applies "fantasy-theme analysis" and the symbolic convergence theory to stories and artifacts related to Thalhimers. A conclusion discusses the end of the department store era including a deeply personal goodbye from the author.

Go to article

Building Hypertext In The Elementary School Art Classroom: An Integrated Approach To Learning And Curriculum, Talitha Church Jan 2005

Building Hypertext In The Elementary School Art Classroom: An Integrated Approach To Learning And Curriculum, Talitha Church

Theses and Dissertations

In response to the many demands and pressures faced by both students and teachers in public schools, the art teacher in this action research study searched for ways to change her teaching practices to facilitate active inquiry. She utilized Thinking Maps®, a specialized form of graphic organizers, and Inspiration®, a hypertext linking program to promote interdisciplinary teaching and learning. The goals of the study were to increase student engagement, improve learning, and promote higher order thinking in elementary school art classes. The target group was comprised of the third grade students at Saunders Elementary School in Newport News, Virginia. Each …

Go to article

Long Walk In Flight School, William H. May Iv Jan 2005

Long Walk In Flight School, William H. May Iv

Theses and Dissertations

Long Walk in Flight School is a document intended to complement a body of artwork that includes photographs, giclee prints, animation, and a twenty two page book of images. The main focus of the text is to discuss two types of exchange; my energy with tools in exchange for an object or event, which is then exchanged in the imagination of the audience for something else, a hybrid thing. These exchanges are part of the performance or presentation of the work. Beginning with a brief description of intent at the start of graduate school, it traces my development as an …

Go to article

Detection Of Deformable Objects In A Non-Stationary Scene, Sherif Azary Jan 2005

Detection Of Deformable Objects In A Non-Stationary Scene, Sherif Azary

Theses

Image registration is the process of determining a mapping between points of interest on separate images to achieve a correspondence. This is a fundamental area of many problems in computer vision including object recognition and motion tracking. This research focuses on applying image registration to identify differences between frames in non-stationary video scenes for the purpose of motion tracking. The major stages for the image registration process include point detection, image correspondence, and an affine transformation. After applying image registration to spatially align the image frames and detect areas of motion segmentation is applied to segment the moving deformable objects …

Go to article

An Investigation Of Techniques In Deformable Object Recognition, Gavin S. Page Jan 2005

An Investigation Of Techniques In Deformable Object Recognition, Gavin S. Page

Theses

The human's innate ability to process information garnered from a visual scene has no parallel in the digital realm. This task is taken for granted in human cognition, but has not been met by a complete digital solution even following years of research. This difficulty can be explained by the shear complexity of the physology of the visual pathway. Although a complete solution has not been created, there are a number of examples of solutions that address parts of the problem. The recognition of deformable objects is the area addressed in this work. The specific task researched was the recognition …

Go to article

The Effects Of Footshock On The Reinforcing Efficacy Of Cocaine In Male Long-Evans Rats, Elizabeth S. Hendrick Jan 2005

The Effects Of Footshock On The Reinforcing Efficacy Of Cocaine In Male Long-Evans Rats, Elizabeth S. Hendrick

Theses and Dissertations

Many links exist between cocaine abuse and stress. The literature and laboratory studies in rats suggest that this could be because stress increases the reinforcing efficacy of cocaine. Using male Long-Evans rats, experiments in this thesis tested effects of footshock on the reinforcing efficacy of cocaine using a progressive ratio schedule of reinforcement. They also examined effects of footshock on the reinforcing efficacy of a half-maximal dose of cocaine. Finally, they tested the effects of footshock on cocaine self-administration in rats initially resistant to acquisition of cocaine self-administration. Footshock did not increase reinforcing efficacy of cocaine on a PR schedule …

Go to article

First Prev Next Last