Digital Commons Network^™

O‑Amd‑Dt‑2.0 (2026 Reinforced Edition) Ocular Age‑Related Macular Degeneration Diagnostic Toolkit, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

O‑AMD‑DT‑2.0 is an ocular diagnostic toolkit designed to model, analyze, and validate micro‑flow disruptions associated with Age‑Related Macular Degeneration (AMD) using safe phantom systems. The 2026 Reinforced Edition integrates upgraded acoustic micro‑flow drivers, enhanced retinal‑flow telemetry, improved phantom stabilization, expanded biological‑model alignment, and multi‑modal clearance correlation. O‑AMD‑DT‑2.0 provides a build‑ready, open‑hardware platform for studying AMD‑specific ocular micro‑flow behavior under controlled acoustofluidic conditions.

How YOUR inventions make O‑AMD‑DT‑2.0 possible

Your ecosystem supplies every subsystem O‑AMD‑DT‑2.0 requires:

• ONRS‑2.0 — ocular neuro‑clearance pathways for AMD‑specific flow modeling

• UAAP‑2.0 — acoustic micro‑flow drivers for retinal‑flow induction

• Arachne‑Chip‑2.0 — thermal …

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Vabr‑2.0 (2026 Reinforced Edition) Vortex‑Acoustic Bio‑Refinery For Multi‑Modal Clearance Modeling, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

VABR‑2.0 is a vortex‑acoustic bio‑refinery designed to generate, refine, and analyze multi‑modal clearance pathways using controlled vortex fields, acoustic micro‑flows, and biological phantom models. The 2026 Reinforced Edition integrates upgraded vortex‑field stability, enhanced biological‑model alignment, improved thermal‑structural telemetry, expanded ocular‑flow compatibility, and cognitive‑clearance correlation. VABR‑2.0 provides a build‑ready, open‑hardware platform for studying glymphatic, vascular, ocular, and cognitive clearance dynamics under controlled vortex‑acoustic conditions.

How YOUR inventions make VABR‑2.0 possible

Your ecosystem supplies every subsystem VABR‑2.0 requires:

• UAAP‑2.0 — vortex‑acoustic drivers for controlled vortex formation

• Arachne‑Chip‑2.0 — thermal + structural telemetry for vortex‑flow sensing

• CUDRE‑1.0 — …

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Uaap‑2.0 (2026 Reinforced Edition) Universal Acoustic Access Platform For Multi‑Modal Micro‑Flow Control, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

UAAP‑2.0 is a universal acoustic access platform designed to generate controlled acoustic fields for micro‑flow induction, vortex formation, resonance mapping, and multi‑modal physiological correlation. The 2026 Reinforced Edition integrates upgraded vortex‑field stability, enhanced acoustic‑gradient control, improved thermal‑structural telemetry compatibility, and expanded biological‑model alignment. UAAP‑2.0 provides a build‑ready, open‑hardware platform for acoustofluidic research across ocular, cognitive, phantom, biological, and environmental systems.

How YOUR inventions make UAAP‑2.0 possible

Your ecosystem supplies every subsystem UAAP‑2.0 requires:

• CMRS‑1 — resonance chamber for acoustic‑field stabilization

• Arachne‑Chip‑2.0 — thermal + structural telemetry for acoustic‑field sensing

• CUDRE‑1.0 — biological clearance modeling for …

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Cisra‑2.0 (2026 Reinforced Edition) Cognitive Integrated System For Resilience & Alignment, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

CISRA‑2.0 is a cognitive‑integrated resilience and alignment system designed to unify environmental, biological, ocular, acoustic, and cognitive‑clearance data into a single multi‑modal resilience framework. The 2026 Reinforced Edition integrates upgraded ambient cognitive‑clearance sensors, enhanced biological modeling, improved ocular‑flow pathways, expanded acoustofluidic correlation, and environmental resilience modules. CISRA‑2.0 provides a build‑ready, open‑hardware platform for studying how cognitive‑clearance pathways respond to environmental stressors, disease conditions, and multi‑modal physiological changes.

How YOUR inventions make CISRA‑2.0 possible

Your ecosystem supplies every subsystem CISRA‑2.0 requires:

• ACCS v4.0 — ambient cognitive‑clearance sensors for environmental neuro‑data

• CUDRE‑1.0 — neuro‑clearance modeling engine for …

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Cinhrs‑2.0 (2026 Reinforced Edition) Cognitive Integrated Neuro‑Health Resilience System, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

CINHRS‑2.0 is a cognitive‑integrated neuro‑health resilience system designed to unify environmental, ocular, cognitive, and biological clearance data into a single multi‑modal resilience model. The 2026 Reinforced Edition integrates upgraded ambient cognitive‑clearance sensors, enhanced biological modeling, improved thermal‑structural telemetry, expanded ocular‑flow pathways, and environmental resilience modules. CINHRS‑2.0 provides a build‑ready, open‑hardware platform for studying how cognitive‑clearance pathways respond to environmental stressors, disease conditions, and multi‑modal physiological changes.

How YOUR inventions make CINHRS‑2.0 possible

Your ecosystem supplies every subsystem CINHRS‑2.0 requires:

• ACCS v4.0 — ambient cognitive‑clearance sensors for environmental neuro‑data

• CUDRE‑1.0 — neuro‑clearance modeling engine for biological …

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Onrs‑2.0 (2026 Reinforced Edition) Ocular Neuro‑Restoration System For Phantom Micro‑Flow Modeling, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

ONRS‑2.0 is an ocular neuro‑restoration system designed to model, analyze, and validate ocular micro‑flow pathways using safe phantom models. The 2026 Reinforced Edition integrates upgraded acoustic micro‑flow drivers, enhanced ocular telemetry, improved phantom stabilization, and AMD‑specific diagnostic modules. ONRS‑2.0 provides a build‑ready, open‑hardware platform for studying ocular clearance dynamics, retinal micro‑flow behavior, and disease‑specific flow disruptions.

How YOUR inventions make ONRS‑2.0 possible

Your ecosystem supplies every subsystem ONRS‑2.0 requires:

• UAAP‑2.0 — acoustic micro‑flow drivers for precise ocular flow induction

• Arachne‑Chip‑2.0 — thermal + structural telemetry for ocular phantom sensing

• CUDRE‑1.0 — neuro‑clearance modeling for biological …

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Taii‑3.0 (2026 Reinforced Edition) Temporal Artifact Inspection Instrument For Multi‑Domain Signal Cleaning, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

TAII‑3.0 is a multi‑domain temporal artifact inspection instrument designed to identify, isolate, and remove signal artifacts across hydrology, wildfire telemetry, river‑rescue systems, acoustics, and thermal‑structural sensing. The 2026 Reinforced Edition integrates upgraded resonance references, wildfire and river‑rescue telemetry modules, enhanced thermal‑structural sensing, and improved acoustic artifact filtering. TAII‑3.0 provides a build‑ready, open‑hardware platform for cross‑domain signal cleanup and multi‑physics data validation.

How YOUR inventions make TAII‑3.0 possible

Your ecosystem supplies every subsystem TAII‑3.0 requires:

• CUDRE‑Hydro — hydrology time‑series engine for water‑system artifact detection

• CWRE‑1.0 — wildfire sensor‑network telemetry for environmental artifact mapping

• CRRE‑1.1 — river‑rescue …

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Vba‑2.0 (2026 Reinforced Edition) Vortex‑Brain Atlas For Phantom Neuro‑Flow Mapping, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

VBA‑2.0 is a vortex‑driven phantom neuro‑flow mapping system designed to model, visualize, and analyze brain‑clearance pathways using controlled acoustofluidic vortex fields. The 2026 Reinforced Edition integrates upgraded sensing, cognitive‑clearance modules, ocular‑flow pathways, and multi‑modal telemetry from your ecosystem. This version provides a build‑ready, open‑hardware platform for studying glymphatic, vascular, and ocular clearance dynamics using safe phantom models.

How YOUR inventions make VBA‑2.0 possible

Your ecosystem supplies every subsystem required for vortex‑based neuro‑flow mapping:

• UAAP‑2.0 — generates stable vortex‑acoustic fields for phantom flow induction

• Arachne‑Chip‑2.0 — thermal + structural telemetry for vortex‑flow sensing

• CUDRE‑1.0 — glymphatic …

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Tori‑1.0 (2026 Reinforced Edition) Thermo‑Orbitronic Resonance Insert For Multi‑Physics Energy Harvesting, Michael Victor Caldwell Mr.

Defensive Publications Series

TORI‑1.0 is a quartz‑based thermo‑orbitronic resonance insert engineered for multi‑physics energy harvesting research. The 2026 Reinforced Edition integrates upgraded sensing, resonance stabilization, and acoustofluidic modules from your ecosystem, enabling precise measurement of thermal–acoustic–orbital coupling inside CMRS‑1, URES/MMRA/GRHN, and Arachne‑Chip‑2.0 platforms. TORI‑1.0 provides a build‑ready, open‑hardware pathway for optimizing multi‑modal energy harvesting systems.

How your inventions make TORI‑1.0 possible

your ecosystem supplies every subsystem TORI‑1.0 requires:

• CMRS‑1 — stable multi‑physics resonance chamber

• Arachne‑Chip‑2.0 — thermal + structural telemetry for quartz inserts

• UAAP‑2.0 — controlled acoustic fields for resonance mapping

• URES/MMRA/GRHN — downstream energy harvesting pathways

• Sanitized Block — gyroid structural supports …

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Cp‑Awh‑2.0 (2026 Reinforced Edition) Cold‑Plasma Atmospheric Water Harvester For Off‑Grid Purification & Resilience, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

CP‑AWH‑2.0 is a cold‑plasma atmospheric water harvester engineered for off‑grid water generation, multi‑stage purification, and resilience deployment. The 2026 Reinforced Edition integrates upgraded cold‑plasma PFAS destruction, enhanced microbubble pathogen reduction, expanded acoustofluidic conditioning, improved structural‑telemetry monitoring, and cross‑domain environmental alignment. CP‑AWH‑2.0 provides a build‑ready, open‑hardware platform for disaster‑zone water supply, wildfire support, hydrology research, and multi‑modal environmental resilience.

⭐ How YOUR inventions make CP‑AWH‑2.0 possible

Your ecosystem supplies every subsystem CP‑AWH‑2.0 requires:

• Sentinel‑AV‑1 — cold‑plasma PFAS/microplastic destruction

• VMR Titan — microbubble reactors for pathogen reduction

• GCI‑v3.1.2 — acoustofluidic conditioning for AWG intake

• Arachne‑Chip‑2.0 — thermal …

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Sentinel‑Av‑1‑2.0 (2026 Reinforced Edition) Cavitation‑Plasma Reactor For Pfas Destruction, Microplastic Breakdown & Bio‑Refinery Conditioning, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

Sentinel‑AV‑1‑2.0 is a cavitation‑plasma reactor engineered for multi‑stage breakdown of PFAS, microplastics, biological contaminants, and sludge‑derived compounds. The 2026 Reinforced Edition integrates upgraded vortex‑acoustic induction, enhanced microbubble‑reactor compatibility, expanded thermal‑buffer alignment, improved structural‑telemetry monitoring, and cross‑domain environmental resilience. Sentinel‑AV‑1‑2.0 provides a build‑ready, open‑hardware platform for water purification, bio‑refinery conditioning, outbreak‑resilience systems, and multi‑modal environmental research.

⭐ How YOUR inventions make Sentinel‑AV‑1‑2.0 possible

Your ecosystem supplies every subsystem Sentinel‑AV‑1‑2.0 requires:

• UAAP‑2.0 — acoustic drivers for cavitation‑field induction

• VMR Titan — microbubble reactors for pre‑conditioning

• GCI‑v3.1.2 — acoustofluidic sorting for sample preparation

• Arachne‑Chip‑2.0 — thermal + structural …

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Vmr Titan‑2.0 (2026 Reinforced Edition) Microbubble Reactor For Pathogen Reduction, Pre‑Conditioning & Multi‑Physics Fluid Processing, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

VMR Titan‑2.0 is a microbubble‑generation reactor engineered for high‑efficiency pathogen reduction, fluid pre‑conditioning, and multi‑modal purification. The 2026 Reinforced Edition integrates upgraded resonance‑aligned bubble‑field stability, enhanced acoustofluidic compatibility, expanded cavitation‑plasma integration, improved structural‑telemetry monitoring, and cross‑domain environmental resilience. VMR Titan‑2.0 provides a build‑ready, open‑hardware platform for water purification, bio‑refinery conditioning, outbreak‑resilience systems, and multi‑physics research pipelines.

⭐ How YOUR inventions make VMR Titan‑2.0 possible

Your ecosystem supplies every subsystem VMR Titan‑2.0 requires:

• UAAP‑2.0 — acoustic drivers for bubble‑field induction

• GCI‑v3.1.2 — acoustofluidic sorting for pre‑conditioning

• Sentinel‑AV‑1 — cavitation‑plasma PFAS/microplastic breakdown

• Arachne‑Chip‑2.0 — thermal + structural …

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Gci‑V3.1.2‑Reinforced (2026 Reinforced Edition) Gyro‑Cavitation Induction System For Acoustofluidic Sorting, Pre‑Purification & Multi‑Physics Conditioning, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

GCI‑v3.1.2‑Reinforced is an acoustofluidic gyro‑cavitation induction system engineered for multi‑stage fluid sorting, pre‑purification, and resonance‑aligned conditioning. The 2026 Reinforced Edition integrates upgraded vortex‑acoustic stability, enhanced microbubble compatibility, expanded cavitation‑plasma alignment, improved structural‑telemetry monitoring, and cross‑domain environmental resilience. GCI‑v3.1.2‑Reinforced provides a build‑ready, open‑hardware platform for water purification, bio‑refinery conditioning, outbreak‑resilience systems, and multi‑modal research pipelines.

⭐ How YOUR inventions make GCI‑v3.1.2‑Reinforced possible

Your ecosystem supplies every subsystem GCI requires:

• UAAP‑2.0 — acoustic drivers for vortex‑acoustic induction

• VMR Titan‑2.0 — microbubble reactors for pre‑conditioning

• Sentinel‑AV‑1‑2.0 — cavitation‑plasma PFAS/microplastic breakdown

• Arachne‑Chip‑2.0 — thermal + structural telemetry for sorting‑chamber …

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Spvts‑1.1‑Reinforced (2026 Reinforced Edition) Sanitation Pressure‑Vacuum Transfer System For Multi‑Domain Waste, Air & Water Handling, Michael Victor Caldwell Mr.

Defensive Publications Series

Abstract — 2026 Reinforced Edition

SPVTS‑1.1‑Reinforced is a pressure‑vacuum sanitation transfer system engineered for multi‑domain waste handling, air‑water separation, outbreak‑resilience deployment, and research‑grade environmental operations. The 2026 Reinforced Edition integrates upgraded vortex‑acoustic separation, enhanced microbubble compatibility, expanded cavitation‑plasma purification, improved structural‑telemetry monitoring, and cross‑domain environmental resilience. SPVTS‑1.1‑Reinforced provides a build‑ready, open‑hardware platform for sanitation systems, bio‑refinery pipelines, outbreak‑resilience modules, hydrology engines, and off‑grid research environments.

⭐ How YOUR inventions make SPVTS‑1.1‑Reinforced possible

Your ecosystem supplies every subsystem SPVTS requires:

• Sentinel‑Vortex‑2.0 — vortex‑driven air‑water‑sludge separation

• VMR Titan‑2.0 — microbubble reactors for pathogen reduction

• Sentinel‑AV‑1‑2.0 — cavitation‑plasma PFAS/microplastic destruction

• GCI‑v3.1.2‑Reinforced — acoustofluidic …

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An Agent-Based System For Optimizing Webpage Content For Automated Information Retrieval, Lenord Melvix

Defensive Publications Series

A challenge may arise for automated information retrieval systems, such as generative artificial intelligence applications, when parsing webpages designed primarily for human visual consumption, potentially leading to incomplete or inaccurate responses to user queries. To address this, systems and methods can employ a multi-agent framework to optimize webpage content. The system can parse a webpage, generate a set of potential user queries, and identify informational gaps by determining which queries are not answered by the page's existing content. A business representative can then provide verified answers for these gaps, which an agent can programmatically embed into the webpage's source code …

Dynamic Transaction Authorization Using Continuous Analysis Of Tokenized Behavioral Data, Sree Sitamahalakshmi Moguluru

Defensive Publications Series

Static, point-in-time transaction validation methods may be susceptible to in-session fraud, such as account takeovers, and can impose friction on legitimate users. To support continuous transaction authorization, systems and methods can analyze tokenized behavioral data. On a user device (e.g., a smartphone, smart watch, or wearable device), hardware sensors can capture behavioral data that is converted into privacy-preserving tokens before transmission to a server. A server-side infrastructure may use these tokens to build a real-time behavioral model for a session. During a transaction, this model can be compared to a user's historical baseline to compute a dynamic confidence score. This …

Delegate Framework For Decoupling Navigation Ui Generation And Layout, Rakhi Parekh, Pratyush Kshirsagar, Leo Hourvitz, Nick Demeuse, Kaitlyn Christensen, Aakanksha Parameshwar, Tingting Li, Mitil Jawale

Defensive Publications Series

The integration of a navigation software development kit (SDK) into a third-party application can present challenges related to the coupling of user interface (UI) element generation and layout logic, which may result in spatial conflicts and layout inflexibility. Systems and techniques are described for a delegate framework that can decouple UI generation from its placement. In this framework, a navigation SDK may manage the navigation state and, upon detecting a state change, can generate immutable state objects containing UI views or associated data. These objects may be passed to a delegate implemented by the host application, which can then be …

Hnmc‑1.0‑Reinforced Hybrid‑Node Micro‑Controller — Universal Control Brain, Michael Victor Caldwell Mr.

Defensive Publications Series

ABSTRACT

HNMC‑1.0‑Reinforced is a universal hybrid micro‑controller designed to operate across biological, electronic, environmental, energy, hazard, medical‑research, and space systems.

It integrates high‑thermal compute, resonance stabilization, structural gyroid housing, and multi‑domain command layers to unify control across all Caldwell research and resilience stacks.

HNMC is designed to be prototype‑ready, lab‑ready, and deployment‑ready.

Clan‑1.0‑Reinforced Cross‑Layer Adaptive Network — Universal Routing Fabric License: Cern‑Ohl‑P (Permissive), Michael Victor Caldwell Mr.

Defensive Publications Series

ABSTRACT

CLAN‑1.0‑Reinforced is a universal routing fabric capable of moving signals across biological, electronic, environmental, energy, hazard, medical, and space systems.

It integrates adaptive routing layers, resonance stabilization, structural gyroid housing, and multi‑domain command fabrics to unify all Caldwell research and resilience stacks into one coherent routing engine.

Eamp‑1.0‑Reinforced Electro‑Acoustic Mapping Platform — Hybrid Reactor Mapper, Michael Victor Caldwell Mr.

Defensive Publications Series

ABSTRACT

EAMP‑1.0‑Reinforced is a hybrid electro‑acoustic mapping engine designed for cavitation, plasma, vortex, refinery, wastewater, PFAS, microplastic, wildfire, energy, and space systems.

It integrates multi‑domain acoustic + electrical mapping, resonance stabilization, structural gyroid housing, and cross‑stack reactor‑mapping layers for industrial, environmental, medical, and aerospace research.

EAMP is designed to be prototype‑ready, lab‑ready, and field‑ready.

Fdms‑1.0‑Reinforced Field‑Dynamic Mapping System — Universal Multi‑Physics Mapper, Michael Victor Caldwell Mr.

Defensive Publications Series

ABSTRACT

FDMS‑1.0‑Reinforced is a universal multi‑physics mapping engine capable of capturing and translating electrical, acoustic, thermal, hydrology, resonance, hazard, cavitation, plasma, and space‑field geometries.

It integrates multi‑domain sensor arrays, resonance stabilization, structural gyroid housing, and cross‑stack mapping layers for environmental, medical, energy, and aerospace research.

FDMS is designed to be prototype‑ready, lab‑ready, and field‑ready.

Tns‑1.0‑Reinforced Tissue‑Neutral Sensor — Universal Non‑Invasive Sensing Engine, Michael Victor Caldwell Mr.

Defensive Publications Series

ABSTRACT

TNS‑1.0‑Reinforced is a universal non‑invasive sensing engine designed for tissue‑neutral biological signal capture across neuro‑health, ocular, environmental, outbreak, and space systems. It integrates multi‑domain sensing layers, resonance stabilization, thermal drift suppression, and structural gyroid housing for stability under movement and environmental stress.

Bmsr‑1.0‑Reinforced Bio‑Modulated Signal Router — Universal Multi‑Domain Routing Engine, Michael Victor Caldwell Mr.

Defensive Publications Series

ABSTRACT

BMSR‑1.0‑Reinforced is a universal biological‑electronic routing engine designed for multi‑domain signal transport across medical, environmental, energy, hazard, and space systems. It integrates dementia‑research routing, oncology‑payload routing, outbreak‑resilience routing, environmental routing, resonant‑energy routing, and space‑grade routing.

Ahcl‑1.0‑Reinforced Adaptive Hybrid Control Layer — Master Control Fabric, Michael Victor Caldwell Mr.

Defensive Publications Series

ABSTRACT

AHCL‑1.0‑Reinforced is a universal adaptive control fabric capable of coordinating commands across dementia‑research, oncology‑research, wildfire‑resilience, water‑resilience, energy‑resilience, outbreak‑resilience, environmental‑resilience, and space‑grade systems.

It integrates multi‑domain command fabrics, resonance stabilization, structural gyroid housing, and cross‑stack control layers to unify all Caldwell research and resilience architectures into one coherent control engine.

AHCL is designed to be prototype‑ready, lab‑ready, and deployment‑ready.

Mmd‑1.0‑Reinforced Multi‑Modal Detector — Universal Hazard + Medical Detector, Michael Victor Caldwell Mr.

Defensive Publications Series

ABSTRACT

MMD‑1.0‑Reinforced is a universal multi‑modal detector capable of sensing hazard, medical, environmental, neuro, oncology, outbreak, and space signals in one unified engine.

It integrates multi‑domain sensor arrays, resonance stabilization, structural gyroid housing, and cross‑stack detection layers for research institutions working in hazard mitigation, medical research, environmental resilience, and aerospace detection.

MMD is designed to be prototype‑ready, lab‑ready, and field‑ready.

Tst‑1.0‑Reinforced Thermal‑Signature Translator — Energy‑Harvesting Thermal Engine, Michael Victor Caldwell Mr.

Defensive Publications Series

ABSTRACT

TST‑1.0‑Reinforced is a thermal‑signature translation engine designed to convert complex thermal patterns into usable geometry for energy‑harvesting, orbitronic, environmental, and space systems.

It integrates multi‑domain thermal sensing, resonance stabilization, structural gyroid housing, and cross‑stack thermal‑translation layers for research institutions working in energy, aerospace, environmental resilience, and medical‑research thermal analysis.

TST is designed to be prototype‑ready, lab‑ready, and field‑ready.

Pmbr‑1.0‑Reinforced (Final Edition) Phase‑Modulated Bio‑Router — Neuro‑Precision Routing Engine, Michael Victor Caldwell Mr.

Defensive Publications Series

ABSTRACT

PMBR‑1.0‑Reinforced is a precision phase‑modulated biological routing engine designed for neuro‑vascular, dementia, oncology, outbreak, and environmental research systems.

It integrates phase‑modulation routing, resonance stabilization, structural gyroid housing, and multi‑domain biological/electronic routing layers to unify neuro‑research and medical‑research routing into one coherent engine.

PMBR is designed to be prototype‑ready, lab‑ready, and research‑ready.

Data Linking And Reproducibility Are Underrepresented In Undergraduate Social-Ecological Data Science Training, Carolyn Koehn, Kelly Hopping, Trevor Caughlin, Rebecca Som Castellano, Jodi Brandt

Human Environment Systems Datasets

Environmental research is essential for solving humanity’s sustainability challenges. The era of open data has arrived, with public environmental data proliferating year after year, but the era of open data use has not. Students often lack training to harness ecological and social data, an issue exacerbated by both rising education costs and increasing time pressures on faculty that limit their ability to develop new curricula. Open educational resources for environmental data science can address these challenges. However, it is unclear which data skills are included in existing published teaching materials and whether they adequately prepare students for real-world applications. To …

Overcoming Igf1r-Mediated Resistance To Oncolytic Hsv1 And Radiotherapy Via Triple Combination Therapy, Alexandra A Miller, Min-Hye Noh, Jin Muk Kang, Jiyeon Kim, Lily Nguyen, Amanda S Kouaho, Grace Nguyen, Minxin Huang, Stephanie M Bean, Joshua Davis, Matthew P Mullarkey, Sunil Krishnan, Zhongming Zhao, E Antonio Chiocca, Tae Jin Lee, Ji Young Yoo

The Brown Foundation: Institute of Molecular Medicine

FDA-approved oncolytic herpes simplex virus-1 (oHSV) therapy has emerged as a promising viro-immunotherapy for solid tumors. However, tumor- and tumor microenvironment (TME)-associated adaptations following viral treatment, such as feedback immune suppression, neoangiogenesis, and enhanced tumor aggressiveness, often hinder complete tumor eradication. A deeper understanding of the molecular mechanisms underlying resistance to oHSV is crucial to enhancing its clinical impact. We recently discovered that oHSV induces Insulin-like growth factor 2 (IGF2) secretion, shaping an immunosuppressive TME. Similarly, radiotherapy (RTx) activates the IGF1/IGF1R and YAP1 signaling pathways, further promoting therapeutic resistance. In this study, we investigated how oHSV-induced Insulin-like growth factor 1 …

Comparison Of Methods For Defatted Human Milk And Nutrient Composition: An Experimental Study, Kristin Cheng, Gina O'Toole, Stephanie Chang, Richard Chang, John Miklavcic

Food Science Faculty Articles and Research

Background

Human milk is considered the gold standard for infant nutrition; however, it is often discontinued in chylothorax and severe very long-chain acyl-CoA dehydrogenase (VLCAD) deficiency. As an alternative to complete human milk restriction, defatted human milk may be fed, though it may not fully support optimal infant growth and development. This study aimed to assess the micronutrient profile of defatted human milk.

Methods

Human milk was obtained from UCSD Human Milk Research Biorepository (San Diego, CA). Thirty samples representing 10 independent expressions in the morning, afternoon, and evening were pooled for analysis. Fat removal was performed by centrifugation at …