Digital Commons Network^™

Bull’S-Eye On Borrelia: A Commensal And Consequential Pathogen, Alan L. Gillen

Faculty Publications and Presentations

If Lyme disease causes such urgent and chronic disease issues, where do Borrelia bacteria and ticks fit into a very good creation (Genesis 1)? How did bacteria and ticks change to rely on different hosts and blood for survival? And how are these adaptations informing today’s research in bacteriology, immunology, entomology, and disease ecology? The purposeful placement of Borrelia (Fig. 1) is most likely in the gut of wild mice (Fig. 2), not domesticated mice nor man. The bacteria are communalistic in wild mice, where they may be probiotic for mutual good (Fig. 2)—the Creator made it for good at …

Mechanistic Basis Of Bifunctional Oxidation By A Non-Heme Fe(Ii)/2-Oxoglutarate-Dependent Enzyme Cctet Toward N6-Methyladenine And 5-Methylcytosine In Double-Stranded Dna, Bhargav Varada, Simahudeen Bathir Jaber Sathik Rifayee, Midhun George Thomas, Ethan Sommer, Carter Davis, Sodiq Waheed, Sudheesh Devadas, Surajit Kalita, Sreerag Melayikandy, Tatyana Karabencheva-Christova, Christo Christov

Michigan Tech Publications

CcTET (Coprinopsis cinerea ten-eleven translocation) is a non-heme Fe(II)/2-oxoglutarate (2OG)-dependent oxygenase that catalyzes the oxidative demethylation of both N⁶-methyladenine (6mA) and 5-methylcytosine (5mC) in double-stranded DNA, distinguishing it from other TET enzymes that act exclusively on 5mC. Despite this bifunctional activity, the molecular origins of its substrate selectivity and catalytic mechanism remain poorly understood. Here, we employed a multiscale computational approach combining classical molecular dynamics simulations and hybrid quantum mechanics/molecular mechanics calculations to characterize the conformational dynamics and reaction pathways of CcTET. Our results show that CcTET follows the canonical Fe(IV)=O-mediated mechanism, in which hydrogen atom transfer (HAT) …

Support The Icc As A Vital Court Of Last Resort For Victims Of Grave International Crimes, Jocelyn Getgen Kestenbaum, Gabor Rona

Online Publications

This public statement, issued on International Justice Day (July 17, 2026), affirms support for the International Criminal Court (ICC) as an independent judicial institution and a court of last resort for victims of genocide, crimes against humanity, war crimes, and the crime of aggression. Signed by more than 100 organizations and individuals, including legal scholars, practitioners, human rights advocates, and civil society organizations, the statement expresses concern over efforts to undermine the ICC's independence and functioning. It calls on the United States to reaffirm its longstanding commitment to the rule of law, judicial independence, and international accountability, emphasizing the importance …

Mechanistic Determination Of Host Environmental Impacts On Shigella Virulence, Nicholas E. Dickenson

Funded Research Records

No abstract provided.

Newton Bryan V. City Of Philadelphia

2026 Decisions

USDC for the Eastern District of Pennsylvania

Injuries In Children Undergoing Subspecialty Abuse Evaluations Because Of Intimate Partner Violence., M Katherine Henry, Gunjan Tiyyagura, Joanne N. Wood, Jan Leonard, Kristine A. Campbell, Daniel M. Lindberg, Angela N. Bachim, Farah W. Brink, Lori D. Frasier, Nancy S. Harper, Claire Hickey, Natalie Laub, John D. Melville, Hannah Sahud, Philip V. Scribano

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND AND OBJECTIVES: Intimate partner violence (IPV) and child physical abuse often co-occur, but the frequency and risk factors for abusive injuries in IPV-exposed children remain unknown. Our objectives were to (1) determine frequency of skeletal surveys (SSs) and neuroimaging use because of IPV and their diagnostic value in children aged less than 24 months evaluated by a child abuse pediatrics specialist (CAP) and (2) identify factors associated with performance of and findings on SS and neuroimaging.

METHODS: We conducted a retrospective study of children aged less than 24 months undergoing CAP consultations because of IPV exposure from February 2021 …

Felishatay Alvarado V. City Of Philadelphia

2026 Decisions

USDC for the Eastern District of Pennsylvania

Interstitial Fluid N-Glycans Serve As A Proxy For Serum Biomarker Discovery In A Pilot Study, Radka Saldova, Talus K. Gaymore, Caitriona Walsh, Eder Zavala, Paula M. Mendes

Student Papers, Posters & Projects

Protein glycosylation is the most prevalent post-translational modification and is known to undergo profound alterations in disease. While serum N-glycosylation has been extensively studied, interstitial fluid is gaining prominence as a minimally invasive biomarker source, underscored by the widespread clinical adoption of wearable glucose monitors in diabetic patients. However, the glycomic landscape of interstitial fluid remains largely unexplored. Here, we have performed a comparative analysis of the N-glycome from interstitial fluid and matched plasma from five healthy volunteers using liquid chromatography, mass spectrometry and exoglycosidase digestions. Strikingly, the interstitial fluid N-glycome closely shows overlapping profiles with the plasma of each …

Less Frequent Versus More Frequent Cervical Examinations In Labor: A Systematic Review And Meta-Analysis, Alessandro Petrecca, Benedetta Bina, Chiara Tersigni, Tullio Ghi, Vincenzo Berghella

Department of Obstetrics and Gynecology Faculty Papers

BACKGROUND: Digital cervical examinations are central to intrapartum care, yet their optimal frequency remains uncertain and is largely based on consensus rather than high-quality evidence.

OBJECTIVES: To compare less frequent versus more frequent cervical examinations during labor in terms of obstetrical, maternal and neonatal outcomes.

SEARCH STRATEGY: We searched Medline, Cochrane Library, EMBASE, PubMed Central, Scopus and ClinicalTrials.gov from inception to August 2025, without language or geographic restrictions. The review was registered in PROSPERO (CRD420251033729).

SELECTION CRITERIA: Randomized controlled trials comparing different frequencies of cervical examinations in term singleton pregnancies during labor were included.

DATA COLLECTION AND ANALYSIS: Two reviewers …

Association Of New Jersey Rifle And Pistol Clubs I V. Attorney General New Jersey

2026 Decisions

USDC for the District of New Jersey

Marlin Lopez-Ramirez V. Attorney General United States Of America

2026 Decisions

Agency

Understanding Structural Risk: Seismic Demand For Low-Fill Slender Fuel Tanks, David Yang, Sam Anderson

Civil and Environmental Engineering Faculty Publications and Presentations

Older fuel storage tanks, such as those in Oregon's CEI Hub, present significant seismic vulnerabilities, prompting proposals to limit storage capacity as a transitional risk mitigation measure before more permanent retrofitting actions. However, a critical knowledge gap exists regarding the applicability of standard analysis methods, like API 650, to low-fill conditions. This study utilizes the Veletsos-Yang iterative fluid-tank interaction procedure to evaluate the seismic demand of low-fill slender tanks. The analysis reveals that low-fill slender tanks exhibit slightly longer impulsive periods compared to fully-filled tanks with identical fill-height to radius ratios. Furthermore, the fixed roof mass of a low-fill tank …

Neurofilament Light Chain (Nfl) As A Surrogate Outcome Measure For Gm2 Gangliosidoses., Kyriakos Martakis, Nicolas J. Abreu, Joshua J. Baker, Peter R. Baker Ii, Ian Billington, T Andrew Burrow, Mallory Factor, Taylor Fields, Cassandra Fields, Jennifer L. Gannon, Megan Grosso, Jorgji Kerthi, Marc C. Patterson, Brian J. Shayota, Michael Strupp, Lennard Strupp, Tatiana Bremova-Ert

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: The GM2 gangliosidoses (GM2) are ultra-rare neurodegenerative disorders caused by deficient hexosaminidase A and/or B activity, leading to lysosomal GM2 ganglioside accumulation. Disease onset ranges from infancy to adulthood, with earlier onset associated with more rapid progression. Neurofilament light chain (NfL), a sensitive marker of axonal injury, has been extensively investigated as a biomarker for neurodegenerative disorders, including GM2.

METHODS: To evaluate its clinical utility as a biomarker for GM2, NfL was measured in patients with GM2 enrolled in a Phase 2b, multinational, rater-blinded study of levacetylleucine [NCT03759665], and in its open-label Extension Phase (EP).

RESULTS: Nineteen participants had …

The Irrepressible/Irresponsible Trap: Justifying Migrant Deaths At The México-U.S. Border From “Prevention Through Deterrence” To “Operation Lone Star”, Álvaro José Corral, Melissa Adams Corral

School of Political Science, Public Affairs, Legal and Security Studies Faculty Publications

Operation Lone Star (OLS), a state-level effort to fortify the México-U.S. border in Texas, marked an escalation in the U.S. “Prevention Through Deterrence” (PTD) policy. How have politicians and government officials justified the escalation of immigration enforcement tactics despite the futility and lethality of these tools? Our theoretical approach relies on Beltrán’s (2020) critical exploration of migrant cruelty to understand how migrant deaths are embedded in practices of Latinx racialization and the productive quality of punishment (Valdez, 2016). This study offers a critical analysis of government documents, news coverage, and official statements concerning migrant deaths to trace the evolution of …

In Re: City Of Chester Pennsylvania

2026 Decisions

USDC for the Eastern District of Pennsylvania

Pharky, Phedro, Phractured, And Stagephright: Complete Genome Sequences Of Four Ek2 Cluster Microbacterium Phages, Susan M. R. Gurney, Medha Gupta, Deeksha Reddy, Gloria Zacharias, Aleda S. Jomy, Carly J. Smith, Matthew T. Mcdonald, Brett M. Condon

Student Papers, Posters & Projects

We report the complete genome sequence of four Microbacterium phages, Pharky, Phedro, Phractured, and StagePhright, isolated using the bacterial host Microbacterium foliorum from soil samples collected in Philadelphia. All four phages are genetically very similar and contain a gene of unknown function, which is uncommon in the EK2 cluster.

Usa V. Alan Dorsey

2026 Decisions

USDC for the Middle District of Pennsylvania

In Re: Boy Scouts Of America And Delaware Bsa Llc

2026 Decisions

USDC for the District of Delaware

Do Voters Understand The Benefits Of Taxes?, Benjamin Carter, Alessandro Del Ponte, Peter Discioli

Political Science Faculty Articles and Research

We use economic experiments to study a fundamental question in political economy: Do voters understand the benefits of taxes? Participants play an economic game as members of a virtual society composed of computer players. In each round, the players earn low or high income, see the distribution of income, and then vote for low or high taxes. We test whether participants vote rationally for high taxes when poor and low taxes when rich, following a classic model in political economy, or whether they focus on the burden of taxes more than the benefits. Across three experiments, poor players voted against …

Propagation Of Dirac Spherical Waves In The Expanding Universe, Karen Yagdjian

School of Mathematical & Statistical Sciences Faculty Publications

The explicit formulas for the spherical solutions of the Dirac equation in the expanding universe are given. The initial value of the solution can be, in particular, a wave function of the hydrogen-like atom or a spherical wave in the Minkowski space, that then propagates in the Friedmann-Lemaître-Robertson-Walker space-time, which is expanding with the de Sitter scale factor.

Beyond Immersion: A Stage-Based Framework For Cross-Modal Immersive Technologies In Medical Education, Christopher M. Ahmad, Ambrose Loc T. Ngo, Rae-Anne Kastle, Lance Rufino, Shantanu Amin, Brent Evan, Melissa Zolnierz

Student Publications

Background

Immersive technologies such as virtual reality (VR), augmented reality (AR), and point-of-care ultrasound are increasingly used in medical education, yet most studies evaluate these tools in isolation. As a result, the relationships among immersive experience, cognitive workload, technical performance, and downstream diagnostic assessment remain poorly understood. This exploratory secondary analysis applied the Immersive Learning Engagement-Performance (ILEP) conceptual framework to a staged multimodal dataset to examine whether selected immersive psychological variables were associated with downstream Extension Proficiency Composite and exploratory distal diagnostic performance.

Methods

This theory-informed secondary analysis used participant-level data from a prospective staged protocol involving VR, AR, and …

Optimising Professional Support For Doctors Who Experience Work Performance Issues: A Realist Evaluation, Nicola Brennan, Ellie Reynolds, Tristan Price, Geoff Wong, Jennifer Cleland, Helen Lloyd, Lyndsey Withers, Thomas Gale

Peninsula Medical School

Background The optimal performance of doctors is critical to delivering high-quality, safe healthcare. However, 6–12% of doctors may experience challenges that impact their work performance. In many countries, including the UK, there is variation in the practice and quality of professional support services between different types of organisations. The aims of our study were (1) to identify why, how, in what contexts and for whom professional support works, (2) to develop a guide for healthcare organisations to use to optimise professional support.Methods We carried out a realist evaluation consistent with Realist And Meta-narrative Evidence Syntheses: Evolving Standards (RAMESES) II standards. …

Together//Apart Explorations In Choreorobotic Performance Ontologies, Kate Sicchio, Patrick J. Martin

Computer Science Faculty Publications

This chapter presents a practice-as-research approach to developing an improvisational choreorobotic performance. Our performance process motivated the creation of new human–robot interaction and live choreography technologies. These technologies were tested during the performance and evaluated by the audience through feedback on their perceptions about the coexistence of humans and machines in a shared space. Examining these results through both autonomous robotics and performance studies ontologies, we formulated a new analytical process in which choreographic practice informs design and robots inform performance.

Cavallo V. Cabral

All Decisions

In this breach of lease/nuisance holdover involving a NYCHA Section 8 tenant, the court dismissed the petition because the landlord failed to comply with the Williams Second Consent Decree. That decree requires that both the predicate notice of termination and the notice of petition and petition be served on NYCHA Section 8 in proceedings against voucher holders.

321-323-325 W. 42nd St. Llc V. Hong

All Decisions

Court granted tenant's motion for leave to amend pro se answer under CPLR 3025(b) in this GCEL holdover premised on alleged nonpayment of rent. Court found landlord failed to show the proposed amended answer patently lacked merit, and that its general claim of prejudice due to the timing of the motion was insufficient.

Omura V. Omura

All Decisions

Handwritten opinion. In this holdover proceeding, the court dismissed the case based on untimely filing of the affirmation of service under RPAPL § 735(2)(b).

Cucs West 127th Street Llc V. Walker

All Decisions

Landlord commenced a nuisance holdover proceeding against a rent-stabilized tenant in a supportive housing building. Tenant moved to dismiss on the ground that the notice of petition used non-standard language substituting 'fair use and occupancy' for the prescribed money judgment language. The court granted the motion, holding the deviation from the mandatory form was not de minimis and rendered the notice of petition fatally defective and unamendable.

Depro: Understanding The Role Of Llms In Debugging Competitive Programming Code, Nabiha Parvez, Md Tanvin Sarkar Pallab, Mia Mohammad Imran, Tarannum Shaila Zaman

Computer Science Faculty Research & Creative Works

Debugging consumes a substantial portion of the software development lifecycle, yet researchers do not yet understand well the effectiveness of Large Language Models (LLMs) in this task. Competitive programming offers a rich benchmark for such evaluation, given its diverse problem domains and strict efficiency requirements. We present an empirical study of LLM-based debugging on competitive programming problems and introduce DePro, a test-case-driven approach that assists programmers by correcting existing code rather than generating new solutions. DePro combines brute-force reference generation, stress testing, and iterative LLM-guided refinement to efficiently identify and resolve errors. Experiments on 13 faulty user submissions from Codeforces …

Llm-Enabled Open-Source Systems In The Wild: An Empirical Study Of Vulnerabilities In Github Security Advisories, Fariha Tanjim Shifat, Hariswar Baburaj, Ce Zhou, Jaydeb Sarker, Mia Mohammad Imran

Computer Science Faculty Research & Creative Works

Large language models (LLMs) are increasingly embedded in open-source software (OSS) ecosystems, creating complex interactions among natural language prompts, probabilistic model outputs, and execution-capable components. However, it remains unclear whether traditional vulnerability disclosure frameworks adequately capture these model-mediated risks. To investigate this, we analyze 295 GitHub Security Advisories published between January 2025 and January 2026 that reference LLM-related components, and we manually annotate a sample of 100 advisories using the OWASP Top 10 for LLM Applications 2025.We find no evidence of new implementation-level weakness classes specific to LLM systems. Most advisories map to established CWEs, particularly injection and deserialization weaknesses. …

“Innocent” Electrolytes Can Influence Organic Electrosynthetic Selectivity, Zachary A. Nguyen, Nhu H. Quach, Mayank Tanwar, Joshua A. Beeler, Kevin Mcfadden, Dylan G. Boucher, Matthew Neurock, Shelley D. Minteer

Chemistry Faculty Research & Creative Works

Organic electrosynthesis has emerged as a powerful strategy for leveraging electricity in organic synthesis. Despite its growing popularity, the fundamental molecular interactions governing electrochemical systems remain poorly understood. Many electrosynthetic reactions show strong dependence on the identity of the allegedly inert supporting electrolyte, which can significantly impact yields and selectivity, yet the physical origins of these effects are largely unexplored. A mechanistic understanding of electrolyte effects would enable more rational reaction design for applications. Here, we use cyclic voltammetry to investigate cobalt-based metal–carbon bond homolysis and elucidate how common supporting electrolytes influence reaction rates. Bulk electrolysis experiments further reveal how …