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Technical Disclosure Specification: Module 5 Integrated Multi-Layer Sub-Wavelength Photonic Crossbar Arrays And Interfacial Refractive Index Transformers For Non-Invasive Optical State Detection In Non-Equilibrium Quantum Matrices, Christopher L. Eckes Jul 2026

Technical Disclosure Specification: Module 5 Integrated Multi-Layer Sub-Wavelength Photonic Crossbar Arrays And Interfacial Refractive Index Transformers For Non-Invasive Optical State Detection In Non-Equilibrium Quantum Matrices, Christopher L. Eckes

Defensive Publications Series

Traditional quantum state readouts introduce an intrusive physical measurement vector—such as direct electrical contact or unshielded magnetic flux—that acts as an unintended observer, instantly collapsing the fluid computational canvas before data extraction is completed. This disclosure specifies a standalone Integrated Multi-Layer Photonic Crossbar Array designed to execute non-invasive, simultaneous optical state tracking across distributed computing blocks. The hardware consists of high-index silicon nitride (Si₃N₄) waveguides embedded directly within the solid fused silica (SiO₂) inverse opal structural skeleton.

Rather than physically breaking into the 5.0 μm hollow spheres, the photonic network uses sub-wavelength evanescent field coupling to probe the active Interfacial …


Technical Disclosure Specification: Module 1 Dual-Phase Centrifugal Sedimentation Protocols And Capillary Infiltration Recipes For The Monolithic Manufacturing And Fluidic Lamination Of Multiblock Quantum Metamaterials, Christopher L. Eckes Jul 2026

Technical Disclosure Specification: Module 1 Dual-Phase Centrifugal Sedimentation Protocols And Capillary Infiltration Recipes For The Monolithic Manufacturing And Fluidic Lamination Of Multiblock Quantum Metamaterials, Christopher L. Eckes

Defensive Publications Series

The transition of a room-temperature quantum computing architecture from a collection of mathematical models to a scalable, physical computer requires a repeatable chemical and mechanical manufacturing framework. This disclosure specifies a standalone Dual-Phase Centrifugal Sedimentation Protocol and cleanroom factory recipe. The specification provides the exact parameters needed to deposit, laminar-flow, and permanently seal a fluidic lipid bilayer substrate inside the sub-micron interconnect tracks of a self-assembled Hexagonal Close-Packed (HCP) inverse opal matrix.

Traditional solid-state fabrication techniques cannot form fluidic quantum boundaries; they induce surface roughness, structural voids, and gas trapping that cause premature phase scattering. This module resolves the lamination …


Heat-Driven Desiccant Comfort And Water Platform For Humid Climates (Land And Marine): Cacl2 Liquid-Desiccant And Aluminum-Fumarate Mof Coated-Exchanger Tracks, Ramon H. Pla Jul 2026

Heat-Driven Desiccant Comfort And Water Platform For Humid Climates (Land And Marine): Cacl2 Liquid-Desiccant And Aluminum-Fumarate Mof Coated-Exchanger Tracks, Ramon H. Pla

Defensive Publications Series

OVERVIEW

A complete, internally consistent paper design — nothing has been built — for a heat-driven desiccant comfort and drinking-water platform for humid-tropical climates, deployable on land and on marine platforms. Input is solar thermal or waste heat at 60–93 °C; outputs are dry cool air, safe indoor air quality (<1,000 ppm CO2 in sealed operation), hot water, and potable water, for occupied volumes of roughly 100 m3 (yacht interiors, small dwellings, cabins, shelters).

The sole governing design point is DP-A: 32 °C / 80% RH (humidity ratio 24.2 g/kg, dew point 28.1 °C) with a raw-water sink near 29 °C. At this condition every ambient heat sink sits at or above the dew point, so sink-cooled condensation harvests essentially no water and …


Technical Disclosure Specificationmodule 4 Monolithic Interdigital Transducer (Idt) Array Casing And Radio-Frequency Electro-Acoustic Coupling Interfaces For Master Multiblock Quantum Topologies, Christopher L. Eckes Jul 2026

Technical Disclosure Specificationmodule 4 Monolithic Interdigital Transducer (Idt) Array Casing And Radio-Frequency Electro-Acoustic Coupling Interfaces For Master Multiblock Quantum Topologies, Christopher L. Eckes

Defensive Publications Series

This disclosure specifies the physical hardware housing, radio-frequency (RF) impedance-matching circuitry, and sub-micron metalized finger geometries required to interface classical control electronics with the non-equilibrium solitonic fluid computing core. To drive the foundational dual-loop acoustic architecture—comprising the 210.75 MHz continuous harmonic processing carrier wave (Loop 1) and the 600 MHz / 1.2 GHz sub-harmonic structural phase-cancellation torque vector array (Loop 2)—a high-precision electro-acoustic transduction layer must be bonded directly to the anisotropic coupling faces of the fused silica (SiO₂) matrix.

This module resolves the critical hardware interface crisis: injecting extreme high-frequency radio waves and converting them into surface acoustic wave …


Master System Architecture For Room-Temperature Ternary Quantum Computers - Monolithic Structural Integration Of Solitonic Cores, Inter-Node Entanglement Bridges, And Modular Control Interfaces, Christopher L. Eckes Jul 2026

Master System Architecture For Room-Temperature Ternary Quantum Computers - Monolithic Structural Integration Of Solitonic Cores, Inter-Node Entanglement Bridges, And Modular Control Interfaces, Christopher L. Eckes

Defensive Publications Series

Traditional quantum hardware development remains fragmented by isolated design cycles, where core qubits, routing networks, driver electronics, and control software are engineered in separate silos. This systemic fragmentation introduces massive integration friction, leading to severe signal mismatches, thermal leaks, and immediate wave collapse when components are wired together. This disclosure specifies a comprehensive, multi-layered Master System Architecture that unifies the complete hardware, software, sensing, and manufacturing layers of a non-equilibrium, room-temperature ternary quantum computer into a single monolithic framework.

This master framework integrates and anchors six distinct operational layers: the core qubit blocks (MS #12489), the fluidic inter-node entanglement ribbons …


Non-Local Solitonic Entanglement Bridges: Lipid-Encapsulated Hydrodynamic Waveguide Architectures For Multiblock Quantum Topologies, Christopher L. Eckes Jul 2026

Non-Local Solitonic Entanglement Bridges: Lipid-Encapsulated Hydrodynamic Waveguide Architectures For Multiblock Quantum Topologies, Christopher L. Eckes

Defensive Publications Series

Traditional multi-node quantum computing architectures remain heavily bottlenecked by severe insertion losses, phase velocity dispersion, and environmental decoherence during inter-chip data routing. Standard approaches rely on complex, high-loss optoelectronic conversions to translate quantum states into photons for fiber-optic transmission, leading to high error rates and immediate wave collapse. This paper introduces an alternative, non-local routing architecture that bypasses classical material transit by establishing foundational quantum entanglement directly within a fluidic mechanical medium.

Discrete computing blocks—comprising self-assembled Hexagonal Close-Packed (HCP) inverse opal matrices—are interconnected via flexible anisotropic fused silica ribbons housing micro-etched transmission tracks. To protect traveling mechanical wave functions from …


Non-Equilibrium Phase-Change Quantum Topology: Reversible Solitonic Wave-Field Stabilization Inside Self-Assembled 3d Inverse Opal Lattices, Christopher L. Eckes Jul 2026

Non-Equilibrium Phase-Change Quantum Topology: Reversible Solitonic Wave-Field Stabilization Inside Self-Assembled 3d Inverse Opal Lattices, Christopher L. Eckes

Defensive Publications Series

Current paradigms in quantum computing remain heavily bottlenecked by environmental decoherence, brute-force cryogenic scaling constraints, and the mechanical fragility of localized qubits. This paper introduces an alternative top-down, wave-first hardware architecture that shifts the operational paradigm from brute-force isolation to dynamic phase boundary transport. By utilizing a solid-state, self-assembled Hexagonal Close-Packed (HCP) 3D inverse opal matrix constructed from fused silica (SiO₂), we establish an omnidirectional phononic bandgap that isolates volatile computational wave-fields from external ambient noise.

The internal hollow spherical cavities of this matrix are lined via Atomic Layer Deposition (ALD) with an Interfacial Phase-Change Memory (iPCM) superlattice structure composed …


Bounded-Blast-Radius Operation Of An Untrusted (Byte-Authentic, Behaviourally-Tainted) Language Model At A Security Gateway, By Composing An Egress- Contained Model Runtime, Output-Path Data-Loss Inspection, Least-Privilege Per-Model Capability Identity, A Quarantine-To-Promote Onboarding Gate, Digest-Bound Inference Provenance, And Fleet- Wide Digest Revocation, Tiago Rosado Jul 2026

Bounded-Blast-Radius Operation Of An Untrusted (Byte-Authentic, Behaviourally-Tainted) Language Model At A Security Gateway, By Composing An Egress- Contained Model Runtime, Output-Path Data-Loss Inspection, Least-Privilege Per-Model Capability Identity, A Quarantine-To-Promote Onboarding Gate, Digest-Bound Inference Provenance, And Fleet- Wide Digest Revocation, Tiago Rosado

Defensive Publications Series

This document discloses an architecture, at a security gateway that mediates a language model’s use inside an organisation, for operating a model that must be assumed untrusted — because the dominant model supply-chain threat is behavioural, not byte-level. A poisoned or backdoored model (weight-level backdoor, trigger-phrase exfiltration, memorised-secret leakage, injection-amplification, steganographic encoding) is byte-authentic: its content hash and any signature over its weights verify perfectly, because the taint lives in learned behaviour, not in the bytes.

Detecting such behavioural backdoors from weights is an open research problem this disclosure does not claim to solve. Instead the disclosed principle …


Longitudinal Learner Profile Construction From Aggregated Multi-Source Educational Data For Personalized Tutoring, Brittany Arthur, Tim Taylor, Teresa Chang, Craig Chase, Mauricio Mendez Ruiz, Gerardo Ocampo Diaz, Sam Goodgame, Tricia Jamison Jul 2026

Longitudinal Learner Profile Construction From Aggregated Multi-Source Educational Data For Personalized Tutoring, Brittany Arthur, Tim Taylor, Teresa Chang, Craig Chase, Mauricio Mendez Ruiz, Gerardo Ocampo Diaz, Sam Goodgame, Tricia Jamison

Defensive Publications Series

Existing educational platforms often operate without longitudinal awareness of student academic histories, with performance data remaining fragmented across disconnected systems, courses, and academic years. This fragmentation limits the ability of tutoring systems to identify root causes of learning difficulties or to leverage documented student strengths when generating instructional responses. The disclosed technology provides a tutoring system that aggregates academic records from multiple educational data sources and constructs unified learner profiles by analyzing both structured data, such as assessment scores, and unstructured educational artifacts, such as essays and teacher feedback. A response generation component synthesizes personalized explanations based on the comprehensive …


Reference Pattern Mapping For Metrology Of Augmented Reality And Virtual Reality Devices, Zhenxing Hu, Qianli Ma, Ali Karbasi, Wenchun Hu, Jun Yang Jul 2026

Reference Pattern Mapping For Metrology Of Augmented Reality And Virtual Reality Devices, Zhenxing Hu, Qianli Ma, Ali Karbasi, Wenchun Hu, Jun Yang

Defensive Publications Series

This publication describes a method for improving the reliability of metrology for characterizing an optical system in augmented reality and virtual reality devices. The method uses pattern mapping based on a reference pattern to detect regions of interest. This pattern mapping approach eliminates the need for repetitive, parameter-sensitive image preprocessing to locate an ROI in an image and enables highly consistent optical metrology across different testers and devices (e.g., displays).


Method For Glint Correspondence, Pezhman Firoozfam, Jason Todd Spencer Jul 2026

Method For Glint Correspondence, Pezhman Firoozfam, Jason Todd Spencer

Defensive Publications Series

A system, such as a head-mounted device, may include an eye tracking subsystem configured to determine a user's cornea position by analyzing specular reflections (i.e., glints) from light sources of the system, which are directed at the user’s eye and captured by a camera of the system. This disclosure describes a software-based method to configure the system to accurately match bright specular reflections in an image to the specific light sources that created them. To achieve this, the algorithm calculates candidate cornea center locations based on the image reflections and determines the most probable center from these accumulated candidates. This …


Initiating Augmented Reality Experience On Smartglasses Based On Quick Response (Qr) Code, Benjamin Hawthorne Hersh, Ruofei Du Jul 2026

Initiating Augmented Reality Experience On Smartglasses Based On Quick Response (Qr) Code, Benjamin Hawthorne Hersh, Ruofei Du

Defensive Publications Series

Distributing applications for wearable devices such as smartglasses can involve the installation of dedicated software on companion devices such as smartphones. This installation creates friction for both users and developers. Machine-readable optical labels such as quick response (QR) codes are utilized to quickly access web-based applications. The QR code is captured by the smartglasses. The smartglasses determine an address such as a universal resource locator (URL) based on the QR code. The smartglasses transmit a request for content with the determined URL to the smartphone. The smartphone retrieves web-based content from a server and sends the content to the smartglasses. …


Power-Managed Navigation Via Wearable Motion Sensing And Event-Triggered Image Capture For Auditory Hazard Alerts, Sumukh Shevde, Nazih Almalki Jul 2026

Power-Managed Navigation Via Wearable Motion Sensing And Event-Triggered Image Capture For Auditory Hazard Alerts, Sumukh Shevde, Nazih Almalki

Defensive Publications Series

Premature battery depletion is caused in a head-worn computing device by the persistent capture of visual data for spatial navigation in low-visibility environments. To mitigate energy consumption, motion data is collected by a wrist-worn peripheral using dead reckoning to estimate positional changes. Image capture functions on the head-worn computing device are held in a suspended state during standard locomotion. Individual frames are captured at a frequency of one frame per second upon calculation of a proximity threshold to a potential hazard. The single frames are transferred over a localized wireless connection to a central mobile unit for hazard identification. Short …


Dynamic Switching Between Low-Resolution Color And High-Resolution Grayscale Images Based On Text Content Queries, Lijun Li Jul 2026

Dynamic Switching Between Low-Resolution Color And High-Resolution Grayscale Images Based On Text Content Queries, Lijun Li

Defensive Publications Series

Text character recognition within visual streams from head-mounted displays is impacted by data transmission constraints and low electrical capacities. Visual data is captured at a default baseline rate (e.g., of one frame per second) to manage data traffic. An image pyramid structure comprising a full-resolution monochrome representation and downscaled color representations is maintained within an image signal processing pipeline. Cooperative processing logic on a paired device determines when context demands greater detail, triggering a transition to the fullresolution monochrome layer. Data transmission volume and power usage are reduced while character recognition processing is sustained.


Context Management Across Browser Windows, Tabs, And Devices, Benjamin Albert Azose, Akancha Murlidhar Gupta Jul 2026

Context Management Across Browser Windows, Tabs, And Devices, Benjamin Albert Azose, Akancha Murlidhar Gupta

Defensive Publications Series

A browser-based agent controlling system is disclosed for intelligently handling contextual information associated with browser-agent interactions when a user opens a new browser tab, browser window, browser instance, application interface, or computing device. The system maintains contextual information associated with one or more browser-agent sessions and determines whether an agentic interface to be instantiated within a newly created browsing environment. The system further determines whether contextual information to be inherited, copied, synchronized, shared, isolated, or otherwise propagated to the newly created browsing environment. Such determinations may be based on domain similarity, content similarity, website category classifications, user interaction history, aggregate …


Adaptive Multi-Agent Artificial Intelligence For Information Technology Operations System For Deterministic, Topology-Aware Network Troubleshooting And Remediation With Closed-Loop Learning, Nikhil P C, Sebastian Jeuk, Atahar Khan, Shibu Nair Jul 2026

Adaptive Multi-Agent Artificial Intelligence For Information Technology Operations System For Deterministic, Topology-Aware Network Troubleshooting And Remediation With Closed-Loop Learning, Nikhil P C, Sebastian Jeuk, Atahar Khan, Shibu Nair

Defensive Publications Series

Proposed herein is a decision-map-driven Troubleshooting Retrieval and Context Software Development Kit (SDK) that converts an incident into an abstract, structured representation and deterministically routes retrieval, using supervisory-tagged data, across non-linear knowledge sources. The sources may include historical incidents, methods of procedure (MOPs), workflows, documentation, telemetry, and topology or Configuration Management Database (CMDB) relationships. The SDK assembles a pre-tokenization structured context bundle that bounds and standardizes evidence for downstream reasoning, improving precision and consistency relative to static runbooks or generic retrieval-augmented generation (RAG). In some implementations, the SDK enriches incident cases with normalized public outage and environmental intelligence based on …


The Composite Computer Structure That Will Facilitate The Ventilation Procedures Of The Computer System That Will Contain The Composite Computer Structure., Punarjeewa Abeysekera Jul 2026

The Composite Computer Structure That Will Facilitate The Ventilation Procedures Of The Computer System That Will Contain The Composite Computer Structure., Punarjeewa Abeysekera

Defensive Publications Series

This paper describes a composite computer structure that will facilitate the ventilation procedures of the computer system that will contain the composite computer structure. The composite computer structure will be utilized for facilitating the ventilation procedures of the computer system that will contain the composite computer structure. The entire computer system that will contain the composite computer structure will consists of a computer that will include a removable computer back cover and the composite computer structure, which will be utilized for facilitating the ventilation procedures. The utilizing composite computer structure will consist of a structure with multiple hollow compartments containing …


Agentic Ai System For Multimodal Event Analytics And Narrative Generation, Huanhuan Wang, Jun Hui Au, Sherelyn Wan Quan Chan Jul 2026

Agentic Ai System For Multimodal Event Analytics And Narrative Generation, Huanhuan Wang, Jun Hui Au, Sherelyn Wan Quan Chan

Defensive Publications Series

An agentic artificial intelligence system for multimodal event analytics and narrative generation includes a multi-layer computational framework configured to autonomously acquire, transform, integrate, and produce event-related analytics. The system includes an event parameterization interface configured to receive user-defined parameters, a specialized orchestration engine configured to coordinate workflow and trigger parallel data processing streams, and a context formulation layer comprising a semantic data synthesis module, a public data extraction module, and a function calling module. The system includes a knowledge integration layer comprising a domain style and context adaptation module, a conflict resolution module configured to utilize a hierarchical dependency graph …


Identifying Daily Oil Market Shocks: Evidence From The Hormuz Crisis, Davide Valenti Dr., Chiara Casoli, Matteo Manera, Luca Pedini Jul 2026

Identifying Daily Oil Market Shocks: Evidence From The Hormuz Crisis, Davide Valenti Dr., Chiara Casoli, Matteo Manera, Luca Pedini

Fondazione Eni Enrico Mattei Working Papers

This paper develops a daily Bayesian structural VAR model of the global crude oil market that decomposes the real price of oil into three fundamental drivers: shocks to global real economic activity, shocks to oil price expectations and shocks to physical oil supply. We combine a daily sign-restriction identification strategy with a posterior filtering step based on monthly physical oil market data, which sharpens the economic interpretation of the estimated daily shocks. We apply the model to provide a real-time interpretation of the main drivers behind the 2026 Strait of Hormuz crisis, one of the largest and most abrupt oil …


Exploring Predictors Of Student And Parent Attendance In A Tier 2 School-Based Program: Implications For Optimizing Attendance In The Coping Power Program, Heather Mcdaniel, Alexa C. Budavari, Belinda E. Hernandez, Elise T. Pas, Catherine P. Bradshaw Jul 2026

Exploring Predictors Of Student And Parent Attendance In A Tier 2 School-Based Program: Implications For Optimizing Attendance In The Coping Power Program, Heather Mcdaniel, Alexa C. Budavari, Belinda E. Hernandez, Elise T. Pas, Catherine P. Bradshaw

Faculty Publications

There is growing interest in the use of multi-component Tier 2 preventive interventions to help address youth behavior problems in schools, yet parent and youth attendance at sessions can be suboptimal, and, if not optimized, can compromise outcomes. The current study explored baseline predictors of parent and youth attendance at the school-based Early Adolescent Coping Power (EACP) program, a preventive intervention for middle schoolers with externalizing problems. Data come from the 375 seventh graders (62% male, 72% Black) who were in the 20 middle schools randomized to receive the EACP intervention and their parents. We identified two latent profiles of …


Ole Miss Strengthens Campuswide Fight Against Hazing, Marisa C. Atkinson Jul 2026

Ole Miss Strengthens Campuswide Fight Against Hazing, Marisa C. Atkinson

University of Mississippi News

OXFORD, Miss. – The University of Mississippi Division of Student Affairs has completed the three-year Hazing Prevention Consortium program, designed to benefit students across campus. Ole Miss is the only Mississippi university and among only a handful in the SEC to do so.


Mitigating Cancer Therapy-Related Cognitive Impairment By Targeted Activation Of Undruggable Phosphatase., Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang Jul 2026

Mitigating Cancer Therapy-Related Cognitive Impairment By Targeted Activation Of Undruggable Phosphatase., Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang

PCOM Scholarly Works

Cancer therapy-related cognitive impairment (CTRCI) is a debilitating neurotoxic condition adversely impacting cancer patients during and post-cancer treatments. The cancer treatments linked to CTRCI include chemotherapy, hormone therapy, targeted therapy, and immunotherapy. Despite CTRCI severely affecting the psychological and social, cognitive functions, and the overall quality of life of cancer survivors, no effective medications are available currently. Our prior studies have indicated hippocampal tyrosine phosphatase protein tyrosine phosphatase receptor type O (PTPRO) as a putative target for CTRCI. However, phosphatase is historically considered undruggable, and delivering drugs across the blood-brain barrier (BBB) is challenging. Here, we developed a novel delivery …


Integrated Construction Uncertainty Quantification Framework Icuqf, Felix Delmonte Jul 2026

Integrated Construction Uncertainty Quantification Framework Icuqf, Felix Delmonte

Mechanical and Civil Engineering Faculty Publications

This study develops ICUQF, an integrated uncertainty framework for digitally instrumented construction megaprojects that unite probabilistic simulation, fuzzy reasoning, Bayesian networks, AI-driven anomaly detection, BIM-linked digital twins, and organizational learning into a single operational architecture. The framework classifies uncertainty into aleatory variability, epistemic gaps, data-centric and model-centric risks, and cognitive or cultural sources, mapping each class to computational treatments such as Monte Carlo engines for stochastic variability, fuzzy intervals and p-boxes for imprecise expert judgments, and hierarchical Bayesian models for coherent evidence aggregation and online updating. ICUQF specifies data pipelines that connect IoT sensing, edge processing, cloud storage, and Common …


Metastatic Large Cell Neuroendocrine Carcinoma: A Rare Cause Of Hypopituitarism, Smriti Nair, Taskeen Ahmed, Jessica Watari Jul 2026

Metastatic Large Cell Neuroendocrine Carcinoma: A Rare Cause Of Hypopituitarism, Smriti Nair, Taskeen Ahmed, Jessica Watari

Division of Internal Medicine Faculty Papers & Presentations

Pituitary metastases from pulmonary large cell neuroendocrine carcinoma (LCNEC) are exceedingly rare but should be considered in patients presenting with arginine vasopressin deficiency and panhypopituitarism in the context of known or suspected metastatic lung cancer. Early recognition and prompt initiation of hormonal replacement therapy are essential to prevent life-threatening endocrine crises and to improve symptom burden. We describe a case of a 43-year-old male who presented with dyspnea, weight loss, and weakness who was found to have metastatic LCNEC involving the liver. Endocrine evaluation revealed central hypothyroidism, central adrenal insufficiency, and later arginine vasopressin deficiency manifested by polyuria and hypernatremia. …


Individual Differences In Generative Ai Effectiveness: An Empirical Puzzle For Hrd Research, Nolan C. Lovett Jul 2026

Individual Differences In Generative Ai Effectiveness: An Empirical Puzzle For Hrd Research, Nolan C. Lovett

Educational Leadership & Workforce Development Faculty Publications

Professionals with similar backgrounds, given identical generative AI tools, achieve sharply different outcomes. This perspectives piece examines what explains that variance, reviewing evidence on cognitive capacity, domain expertise, metacognition, epistemic calibration, personality, and culture, and argues that existing user typologies describe these differences without predicting their consequences. It then extends the puzzle in a direction the static account misses: the same individual differences that shape AI effectiveness are themselves reshaped by sustained AI use, as cognitive offloading, deskilling, and upskilling inhibition operate differently across the expertise distribution. Recent evidence, including deskilling among experienced clinicians and suppressed learning among students using …


Usa V. Brandon Mcintyre Jul 2026

Usa V. Brandon Mcintyre

2026 Decisions

USDC for the District of New Jersey


In Re: Alecto Healthcare Services Llc Jul 2026

In Re: Alecto Healthcare Services Llc

2026 Decisions

USDC for the District of Delaware


Notch Signaling Regulates The Secretion Of Pro-Metastatic Factors In Extracellular Vesicles In Liposarcoma, Menchus Quan, Yi-Kai Liu, Ying Zhao, Madeline Kay, Kai Sun, Timothy P Gavin, Raphael E Pollock, W Andy Tao, Shihuan Kuang Jul 2026

Notch Signaling Regulates The Secretion Of Pro-Metastatic Factors In Extracellular Vesicles In Liposarcoma, Menchus Quan, Yi-Kai Liu, Ying Zhao, Madeline Kay, Kai Sun, Timothy P Gavin, Raphael E Pollock, W Andy Tao, Shihuan Kuang

The Brown Foundation: Institute of Molecular Medicine

Notch signaling is an emerging regulator of liposarcoma (LPS), but its role in mediating communication with the tumor microenvironment (TME) is unclear. Here, we investigate how Notch activation (NICD overexpression) alters the proteomes of LPS-derived extracellular vesicles (EVs). We used quantitative mass spectrometry to profile the EV proteome in multiple contexts: cultured LPS cells, LPS tumor, circulating EVs of LPS-bearing mice, and human LPS samples. We found that Notch signaling increases the secretion of EV proteins that favor tumor progression and metastasis but suppresses immune responses in murine LPS cells. Overlapping murine and human LPS data identifies 18 proteins that …


Water Availability Regulates Maize Reliance On Soil Versus Fertilizer Nitrogen In A Semiarid Environment, Dwarika Bhattarai, Janet Moriles Miller, Sharon A. Clay, David E. Clay Jul 2026

Water Availability Regulates Maize Reliance On Soil Versus Fertilizer Nitrogen In A Semiarid Environment, Dwarika Bhattarai, Janet Moriles Miller, Sharon A. Clay, David E. Clay

Agronomy, Horticulture and Plant Science Faculty Publications

In semiarid environments, early-season water deficits create uncertainty in how much and when N fertilizer should be applied. To minimize indecision, a better understanding of the interrelationships among water availability, N rate, plant N sources, and yields is needed. This study investigated how soil water availability influenced maize (Zea mays L.) yields and utilization of soil- and fertilizer-derived N in semiarid environments in 2020 and 2021. The replicated trials were conducted at 12 sites and determined the impact of water availability and N rate on the sources of N within the grain, and precipitation and N use efficiencies (PUE …


Ophthoevidence Report: Comparative Effects Of Prophylactic Strategies For Post-Intravitreal Injection Endophthalmitis: Protocol For A Systematic Review And Network Meta-Analysis, Maryam Ghadimi, Dena Zeraatkar, João Pedro Lima, Jinhui Ma, Sunir J. Garg, Peter Kaiser, David Steel, Tien Yin Wong, Sobha Sivaprasad, Charles Wykoff, Varun Chaudhary Jul 2026

Ophthoevidence Report: Comparative Effects Of Prophylactic Strategies For Post-Intravitreal Injection Endophthalmitis: Protocol For A Systematic Review And Network Meta-Analysis, Maryam Ghadimi, Dena Zeraatkar, João Pedro Lima, Jinhui Ma, Sunir J. Garg, Peter Kaiser, David Steel, Tien Yin Wong, Sobha Sivaprasad, Charles Wykoff, Varun Chaudhary

Wills Eye Hospital Papers

BACKGROUND: Endophthalmitis is a rare but serious complication of intravitreal injections (IVI). To mitigate the risk of post-injection endophthalmitis (PIE), retinal specialists use different strategies, combining various prophylactic measures. However, existing systematic reviews have evaluated the effects of these measures in isolation, which does not consider their concurrent use in practice. A trustworthy systematic review with network meta-analysis (NMA) by providing a framework for simultaneous comparisons of different prophylactic combinations is essential to guide decision-making.

OBJECTIVES: To present a protocol for addressing the comparative effects of different strategies for the prevention of PIE.

METHODS: We will search Medline, EMBASE, Cochrane …