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USF Tampa Graduate Theses and Dissertations

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Hurricane Impacts On Water Resources: A Look At Nature-Based Solutions To Improve Long-Term Resilience, Fautemeh Sajadi Bami Mar 2024

Hurricane Impacts On Water Resources: A Look At Nature-Based Solutions To Improve Long-Term Resilience, Fautemeh Sajadi Bami

USF Tampa Graduate Theses and Dissertations

Severe storms are a common occurrence in the state of Florida. Hurricane events may cause hazards such as flooding, property damage, death, and many others. Such far-reaching impacts may potentially result in dangerous consequences where they occur. Of interest to this study were the impacts on water resources and water quality caused by storms. Hurricanes can bring about a deluge. An apparent excess of water may cause the notion of water scarcity to seem less significant. However, problems with potable water can be quite frequent due to storms.

This research sought to address the impacts of severe storms on water …


Explorations On Non-Covalent Interactions: From Supramolecules To Drug-Like Molecules, Zhanpeng Zhang Mar 2024

Explorations On Non-Covalent Interactions: From Supramolecules To Drug-Like Molecules, Zhanpeng Zhang

USF Tampa Graduate Theses and Dissertations

Non-covalent interactions are everywhere in our material world. From the microstructures of organisms to the functional materials used in industrial production, whenever matter exists, there are non-covalent interactions between the molecules that build up the matter.The exploration of non-covalent forces helps people understand the intrinsic principles of life processes, it can be applied to create new supramolecular materials as well. Supramolecular chemistry is a research field focusing on the properties and applications of non-covalent interactions. Various non-covalent interactions, such as hydrogen bonds, metal-ligand coordination, π-π interaction, hydrophobic interaction, etc., are objects of research in supramolecular chemistry.

Not only supramolecular chemists, …


Modeling Studies Of An Intensified Reforming/Fischer-Tropsch Synthesis Process For Gas To Liquid Conversion, Brian Gray Mar 2024

Modeling Studies Of An Intensified Reforming/Fischer-Tropsch Synthesis Process For Gas To Liquid Conversion, Brian Gray

USF Tampa Graduate Theses and Dissertations

Despite rigorous study and advancement in fields of green energy, the world's transportation industry remains poised to continue reliance on liquid hydrocarbon fuels. To date, the primary source of diesel and jet fuels is the petroleum industry; however, continuing trends in rising greenhouse gas emissions present a need for study into processes for the production of synthetic hydrocarbon fuels. The most promising technologies to meet this goal are gas-to-liquid (GtL), biomass-to-liquid (BtL) and coal-to-liquid (CtL). The commonality of these technologies is that they utilize a feedstock to produce carbon monoxide and hydrogen gas (syngas) which becomes the building blocks of …


Improving Medical Image Classification Accuracy Through Unsupervised Segmentation And Confounder Mitigation With Limited Data, Nikolai Fetisov Mar 2024

Improving Medical Image Classification Accuracy Through Unsupervised Segmentation And Confounder Mitigation With Limited Data, Nikolai Fetisov

USF Tampa Graduate Theses and Dissertations

Medical images are indispensable for assisting health care professionals to make more accurate cancer diagnosis and prognosis decisions. Several image modalities exist including, but not limited to, histopathology or whole slide images (WSI), computed tomography (CT), positron emission tomography (PET) and radiography (i.e., X-Ray), each having their own application in clinical practice.

Today, machine learning and deep learning methods have evolved to the point of being practically usable. These approaches learn and extract knowledge from data to make possible automating certain tasks. At the point of writing this dissertation, they have reached human-level performance in general image recognition tasks, became …


An Analysis Of Florida Manatee (Trichechus Manatus Latirostris) Rescues (1993-2022) With Recommendations For Future Rehabilitation Program Needs, Katherine Frisch Mar 2024

An Analysis Of Florida Manatee (Trichechus Manatus Latirostris) Rescues (1993-2022) With Recommendations For Future Rehabilitation Program Needs, Katherine Frisch

USF Tampa Graduate Theses and Dissertations

Florida manatees (Trichechus manatus latirostris) are threatened marine mammals that inhabit the coastal and near shore waters along the southeastern United States, primarily Florida. Manatee conservation is multi-faceted. One component of the manatee recovery program is the rescue and rehabilitation program that provides care for sick, injured and orphaned manatees. The science of conservation biology, whose goal is to maintain biodiversity using a multidisciplinary approach, can be applied to aspects of the manatee rescue and rehabilitation program.

A federally authorized, state implemented, rescue system has been in place for many years to rescue and treat injured and orphaned animals. Rescued …


Interfacial Magnetism And Anisotropy In Dirac And Weyl Semimetals, Noah Schulz Mar 2024

Interfacial Magnetism And Anisotropy In Dirac And Weyl Semimetals, Noah Schulz

USF Tampa Graduate Theses and Dissertations

Semimetals have gained intense interest recently due to their exotic magnetic and electronic properties. One of the most widely studied semimetals is graphene, a Dirac semimetal. The utilization of graphene in devices and sensors requires interfacing it with other materials, which may induce potentially strong interfacial effects. Furthermore, graphene alone does not possess magnetic order. Studying the interfacial effects between graphene and magnetic materials is therefore of great importance in the application of graphene to meet modern technological needs. Furthermore, by understanding the fundamental interfacial physics between graphene and magnetic materials, new properties can be unlocked, broadening the possible applications …


Leveraging Systems Thinking For Global Environmental Health, Martha M. Mcalister Mar 2024

Leveraging Systems Thinking For Global Environmental Health, Martha M. Mcalister

USF Tampa Graduate Theses and Dissertations

Environmental health inequities such as household air pollution, inadequate water, sanitation, and hygiene, and chemical pollution persist globally and have myriad consequences on individual and societal well-being. Unfortunately, while billions of dollars and countless hours of research have been applied towards addressing these issues in development, humanitarian, and environmental justice contexts, attempts to reduce the environmental burden of disease can seem successful at first, but then backslide to pre-intervention conditions (or worse). This is indicative of policy resistance, a tendency of complex systems that makes it very difficult to enact change if the “rules” of the system are misunderstood. There …


Effects Of Diminazene Aceturate On Drosophila Melanogaster: A Lipidomic Analysis, Gabriela Suarez Mar 2024

Effects Of Diminazene Aceturate On Drosophila Melanogaster: A Lipidomic Analysis, Gabriela Suarez

USF Tampa Graduate Theses and Dissertations

Pesticides are agents designed to eradicate living organisms to preserve agricultural needs.1 Today the most commonly used pesticides are termed “modern pesticides”, they are characterized by lower lipophilicity and limited stability, making them less time persistent in the environment. Among these modern pesticides are organophosphorus, urea, phenoxy alkanoic, triazine, chloroacetanilide, and glyphosate-based pesticides.2 The issue faced with most of these pesticides is that they affect more than just the targeted pest and pose a danger to not only humans, but also entire ecosystems.1,3,4 While there are many different types of pesticides, insecticides show the most variance and …


A Longitudinal Investigation Of The Relationships Between Experiences With Sexual Harassment, Self-Objectification, And Self-Concept Clarity Among Women, Roxanne N. Felig Mar 2024

A Longitudinal Investigation Of The Relationships Between Experiences With Sexual Harassment, Self-Objectification, And Self-Concept Clarity Among Women, Roxanne N. Felig

USF Tampa Graduate Theses and Dissertations

This longitudinal research investigates the nuanced relationship between sexual harassment and self-concept development among both men and women over a six-week period, presenting a unified model that integrates theories of self-objectification and self-concept clarity. Across three waves of data collection (N= 370, N=315, N=279, respectively), I find evidence that women experience higher rates of sexual harassment, greater self-objectification, and lower self-concept clarity than men. Across time, I find that experiencing sexual harassment predicts heightened self-objectification, which further predicts a disrupted sense of self among both men and women. Critically, this work investigates the reciprocal nature of self-objectification and self-concept clarity, …


African Spirituality In Literature Written By Women Of African Descent, Brigét V. Harley Mar 2024

African Spirituality In Literature Written By Women Of African Descent, Brigét V. Harley

USF Tampa Graduate Theses and Dissertations

African spiritual memory is the thread that connects members of the African diaspora, irrespective where we are or what we are doing. However, because of white supremacy, the longevity of African spiritual memory and its duration as a living, thriving, breathing force often becomes distorted under the weight of anti-black prejudice. This dissertation debunks the myth that people of African descent required outside input from non-Africans and Arabs to establish the world’s oldest and most studied civilizations, Ta-Seti and then the Egyptian Empire. Women writers of African descent capture the ever-present thread of African spiritual memory, providing a glimpse of …


Dissolved Nitrogen Removal In Biochar Amended, High Permeability Media For Urban Stormwater Treatment, Mark Vicciardo Mar 2024

Dissolved Nitrogen Removal In Biochar Amended, High Permeability Media For Urban Stormwater Treatment, Mark Vicciardo

USF Tampa Graduate Theses and Dissertations

Nutrient pollution in stormwater drives the eutrophication of inland and costal waterbodies which leads to sea grass retreat and the proliferation of harmful algal blooms (HAB). These anthropogenic effects destabilize ecosystems, and some HABs can pose direct human health risk. Bioretention, or the storage and controlled discharge of stormwater run-off in an ecologically engineered setting, is a potential solution to this problem. However, it relies heavily on the settling of particles as a nutrient removal mechanism, and thus struggles with pollutants, such as dissolved nitrogen, which is a particular problem in Florida where the geological prominence of phosphorus leaves nitrogen …


Programmable And Scalable Bit-Sliced Vlsi Architecture For Decision Tree Based Machine Learning Edge Inference, Raaga Sai Somesula Mar 2024

Programmable And Scalable Bit-Sliced Vlsi Architecture For Decision Tree Based Machine Learning Edge Inference, Raaga Sai Somesula

USF Tampa Graduate Theses and Dissertations

As the volume and diversity of Internet-of-Things (IoT) data continues to grow, traditional cloud-based processing methods face significant challenges, including latency, bandwidth constraints, and privacy concerns. Our research focuses on employing decision trees (DTs) as an intelligent filtering mechanism on the edge. Preliminary comparisons across four datasets revealed DTs are significantly more efficient than multilayer perceptrons (MLP), saving 97-98\% in area and power, leading to the selection of DT for our proposed architecture for lightweight IoT devices. We propose a novel programmable and scalable custom application specific integrated circuit (ASIC) architecture designed for Decision Tree based ML inference. Each bit-slice …


Automatic Image-Based Nutritional Calculator App, Kejvi Cupa Mar 2024

Automatic Image-Based Nutritional Calculator App, Kejvi Cupa

USF Tampa Graduate Theses and Dissertations

Nutrition plays a pivotal role in shaping an individuals’ health and quality of life, making the evaluation of dietary intake crucial for promoting healthier lifestyle choices. Various solutions, particularly mobile apps, have been developed to facilitate the process of dietary estimation. Accurate nutritional intake assessment relies on two key components: ingredient recognition and food portion estimation. For a mobile app to offer a comprehensive solution for automatic nutritional assessment, it must address both components.

In this work, we focus on a mobile app pipeline: the semi-automatic pipeline which focuses on automatic food ingredient recognition. This pipeline integrates state-of-the-art models for …


Bird Strike Hazard Assessment For The Tampa International Airport, Florida, Usa, Yakubu Ogwu Isah Mar 2024

Bird Strike Hazard Assessment For The Tampa International Airport, Florida, Usa, Yakubu Ogwu Isah

USF Tampa Graduate Theses and Dissertations

Managing wildlife at airports poses a challenge for ensuring safety for aviation traffic. Airports, with their surrounding habitats and infrastructure, serve as attractants for avian species. Threats created by these species have led managers to develop management techniques in and around airports (DeVault et al 2013). One approach is the use of geographic information systems (GIS) for analyzing avian strike data and airport bird surveys. Spatial analysis of strike data identifies species of threat by categorizing strike occurrence, species sizes, phase of flight, and risk of damage. In addition, GIS can be used to map hotspots of bird strikes. These …


Semi-Automated Cell Annotation Framework Using Deep Learning, Abhiram Kandiyana Mar 2024

Semi-Automated Cell Annotation Framework Using Deep Learning, Abhiram Kandiyana

USF Tampa Graduate Theses and Dissertations

Unbiased stereology refers to a field of applied mathematics \cite{intro-to-stereology} focused on accurate (model and assumption-free) quantification of three-dimensional (3D) objects, typically based on their appearance in 2D sections (planes) through the objects. In the biological sciences, these techniques are widely used for making unbiased estimates of arbitrary-shaped (stochastic) objects such as stained cells, blood vessels, region volumes, etc., in tissue sections through a region of interest (ROI).

This fundamental methodology is widely used for evaluating structural changes that occur in diseases, aging, and pharmaceutical interventions, thereby ensuring reliable outcomes. In terms of limitations, stereology is tedious, time- and labor-intensive, …


The Theoretical Epigenetic Relationship Between Complex-Ptsd And Adhd In Holocaust Survivors’ Descendants, Y. Sahara Brodsky Mar 2024

The Theoretical Epigenetic Relationship Between Complex-Ptsd And Adhd In Holocaust Survivors’ Descendants, Y. Sahara Brodsky

USF Tampa Graduate Theses and Dissertations

When comparing ADHD and Complex-PTSD, these two disorders share many overlapping features in both areas of the brain that are affected and the behavioral aspects due to deficits in certain brain regions, such as the prefrontal cortex. It is due to this similarity that I predict that c-PTSD is the precursor to the development of ADHD in later generations. Through epigenetic changes that are consistent with c-PTSD diagnosis, these changes to the brain are then passed down the generational line. When this is combined with trauma transference and generational trauma, it creates a situation where both the behaviors inform how …


Analyzing The Relationship Between Preeclamptic Severity And Placental Methylation, Mackenzie C. Maggio Mar 2024

Analyzing The Relationship Between Preeclamptic Severity And Placental Methylation, Mackenzie C. Maggio

USF Tampa Graduate Theses and Dissertations

Preeclampsia (PE) is a life-threatening hypertensive disorder in pregnancy (HDP) characterized by high blood pressure and proteinuria after 20 weeks of gestation. PE poses significant risks to both maternal and child health. An incomplete etiopathogenesis, diverse disease heterogeneity, and limited intervention and detection strategies further exacerbate and perpetuate PE as a major public health concern. By assessing symptom severity of placental tissues from PE pregnancies and analyzing the DNA methylation differences, this thesis aimed to identify epigenetic variations contributing to disease heterogeneity. Using the publicly available dataset GSE 98224, differentially methylated region (DMR) analysis on placental samples (n=48) revealed increasing …


Under Pressure: The Soft Robotic Clap-And-Fling Of Cuvierina Atlantica, Daniel Mead Mar 2024

Under Pressure: The Soft Robotic Clap-And-Fling Of Cuvierina Atlantica, Daniel Mead

USF Tampa Graduate Theses and Dissertations

Evolution over billions of years has led to unique animals of all types. The tiny sea butterfly is one that remains mostly anonymous because of its size and low place on the food chain, but it is a swimming creature that when examined closely reveals a surprise. Shockingly, it has a swimming motion nearly identical to small insects flying at intermediate Reynolds numbers, referred to as the clap-and-fling. The centimeter long pteropod flapping briskly at 5Hz escapes attention with its size and speed. Modeling the clap-and-fling motion of the sea butterfly at a larger scale allows the benefits and uniqueness …


Nutrient Removal Of Biochar Amended Modified Bioretention Systems Treating Nursery Runoff, Nicholas Richardson Mar 2024

Nutrient Removal Of Biochar Amended Modified Bioretention Systems Treating Nursery Runoff, Nicholas Richardson

USF Tampa Graduate Theses and Dissertations

Excess inputs of nutrients, such as nitrogen and phosphorus, to surface water bodies can lead to the presence of harmful algal blooms (HABs). HABs can damage their surrounding environments and the economies dependent on them. Nutrient pollution can be properly controlled and monitored at point-sources, such as wastewater treatment plants, but is more difficult to control for non-point sources, such as fertilizer runoff. One form of fertilizer runoff that remains overlooked is runoff from plant nurseries. Controlled release fertilizers (CRFs) embedded in plant containers at nurseries can leach excess nutrients into the runoff. For nurseries in Florida, best management practices …


Predicting Gender Of Author Using Large Language Models (Llms), Satya Uday Sanku Mar 2024

Predicting Gender Of Author Using Large Language Models (Llms), Satya Uday Sanku

USF Tampa Graduate Theses and Dissertations

The advent of text data from social media, blogs, movie reviews, and other textual sources has opened new avenues for research, particularly in the domain of Author Profiling. Author Profiling helps in Capturing the Stylistic features and also useful for analyzing the required elements in the written text. This Study addresses one of the tasks in Author Profiling which is termed as gender detection or Classification of Gender from Text. The main goal of this research is to obtain valuable and relevant gender characteristics that will accurately classify the Author’s gender of a review extracted from an Anime Review website. …


Health Status In An Urban-Dwelling, Subtropical Frog Species (Lithobates Sphenocephalus) And Its Relation To Ranavirus And Hemoparasites, Gabrielle M. Wickersham Mar 2024

Health Status In An Urban-Dwelling, Subtropical Frog Species (Lithobates Sphenocephalus) And Its Relation To Ranavirus And Hemoparasites, Gabrielle M. Wickersham

USF Tampa Graduate Theses and Dissertations

Urbanization poses significant challenges to wildlife, including amphibians. The present study uses a multi-parameter approach that incorporates veterinary techniques to investigate the current health status of the adult southern leopard frogs (Lithobates sphenocephalus) in Tampa Bay, Florida, amidst urban stressors including nutrient loading, fragmented habitats, and light and noise pollution. Novel values for fluctuating asymmetry (e.g., variation between left and right bilateral traits; FA), body condition (CF), stress (e.g., neutrophil:lymphocyte (N:L) ratio), and inflammation (e.g., neutrophil morphologic abnormalities, parasite load) are reported. I also investigate the relationship of overall health with ranavirus presence and hemoparasite infections. Ranavirus was absent in …


Interrelationships Among Local Values Of Wet Bulb Globe Temperature, Heat Index, And Adjusted Temperature, Andrea Giraldo Mar 2024

Interrelationships Among Local Values Of Wet Bulb Globe Temperature, Heat Index, And Adjusted Temperature, Andrea Giraldo

USF Tampa Graduate Theses and Dissertations

Occupational heat stress significantly affects outdoor workers who face challenges due to increased heat exposure. Because of the prevalence of heat illness, it is important to measure heat stress for outdoor workers. Monitoring occupational heat stress most often relies on the Wet Bulb Globe Temperature (WBGT) measure. Heat Index (HI) is a widely used measure to account for air temperature and humidity. Adjusted Temperature (Tadj) considers air temperature, humidity and estimates radiant heat. There is interest in predicting WBGT from HI and HI from WBGT. This study builds on previous USF research by Bernard and Iheanacho and Irvin to evaluate …


A Differentially Methylated Region Analysis Between Three Disease States Of Major Depressive Disorder In Primarily African-American Cohorts, Lanie Katelynn Mullins Mar 2024

A Differentially Methylated Region Analysis Between Three Disease States Of Major Depressive Disorder In Primarily African-American Cohorts, Lanie Katelynn Mullins

USF Tampa Graduate Theses and Dissertations

Major depressive disorder (MDD) is a common and debilitating disorder that affects millions of people worldwide. MDD is a multifactorial disease with no established mechanism currently able to explain all facets of the disease or its etiology. Feedback loop mechanisms have been posited to explain the interactions of psychological and physical components of the disease etiology. Epigenetics, specifically DNA-methylation analyses, can shed light on the interaction between the within-person environment resulting from MDD symptomology, the persistence of the disease, and factors influencing remission. Here, a differentially methylated region analysis was conducted using samples derived from whole blood to interrogate the …


Single And Dual Cell Encapsulation Via Liquid Core Hydrogels Using Pico Injection, Jade Houston Mar 2024

Single And Dual Cell Encapsulation Via Liquid Core Hydrogels Using Pico Injection, Jade Houston

USF Tampa Graduate Theses and Dissertations

In this project, a comprehensive microfluidic device, along with several interdependent subsystems, was designed and developed in SolidWorks, leveraging a combination of 3D resin printing with biocompatible resin and micromachining with polymethylmethacrylate (PMMA). The microfluidics chip integrated both passive and active components to facilitate its primary function: dual cell encapsulation via liquid core sodium alginate hydrogel droplets.

Integral to the microfluidics chip design were key features including a 5-convolution Archimedes spiral for particle sorting, a flow focusing junction for droplet generation, and a pico injector for injecting additional cells into passing droplets via the manipulation of an electric field.

An …


Preliminary Investigation Of Differences In Host Mitochondria Membrane Potential During Toxoplasma Gondii Infection, Bryan L. Ortega Mar 2024

Preliminary Investigation Of Differences In Host Mitochondria Membrane Potential During Toxoplasma Gondii Infection, Bryan L. Ortega

USF Tampa Graduate Theses and Dissertations

Toxoplasma gondii is an obligate intracellular protozoan with a broad host range of hosts, including various warm-blooded mammals, including humans. While infections can often be asymptomatic in immunocompetent individuals, they can pose significant risks to those who are immunocompromised, as well as pregnant women. Toxoplasmosis represents a significant burden on public health in the United States, with over 800,000 annual infections reported, often leading to severe complications such as symptomatic eye disease and congenital infections. Recent attention has developed regarding its potential association with human neuropathies such as Alzheimer's disease, dementia, and mood disorders. This project investigated differences in host …


Dissolved Nickel Speciation At The Bermuda Atlantic Time-Series Study (Bats) Site, Caitlyn E. Parente Mar 2024

Dissolved Nickel Speciation At The Bermuda Atlantic Time-Series Study (Bats) Site, Caitlyn E. Parente

USF Tampa Graduate Theses and Dissertations

Here I present the first depth profiles of dissolved nickel (DNi) speciation over an annual cycle at the Bermuda Atlantic Time-series Study (BATS) site in the North Atlantic. Seawater samples were collected in March, May, August, and November 2019 and analyzed for labile DNi using competitive ligand exchange-adsorptive cathodic stripping voltammetry (CLE-AdCSV). Labile DNi was measured by CLE-AdCSV as the fraction of DNi that exchanges with an added competitive ligand in an overnight equilibration. Results revealed two distinct fractions of DNi present throughout the water column: a labile fraction, and a strongly organically complexed (i.e., non-labile) fraction. More than 50% …


Metatranscriptomic Insights Into The Interaction Between Microcystis Blooms And Hydrogen Peroxide, Taylor L. Hancock Mar 2024

Metatranscriptomic Insights Into The Interaction Between Microcystis Blooms And Hydrogen Peroxide, Taylor L. Hancock

USF Tampa Graduate Theses and Dissertations

For this dissertation I studied the interactions of hydrogen peroxide and cyanobacterial harmful algal blooms (cHABs) dominated by Microcystis in the Caloosahatchee River, FL. Specifically, I examined how taxonomic and functional succession relates to both natural hydrogen peroxide dynamics and hydrogen peroxide added to the environment as a cHAB treatment. Chapter 2 investigated how taxonomic succession and gene expression patterns relate to blooms and associated elevated hydrogen peroxide concentrations. The results showed that gene expressions related to cyanobacterial growth were positively correlated with hydrogen peroxide. The genes identified included enzymes capable of hydrogen peroxide generation which were expressed by blooming …


Factors Impacting Genetic Test Result Recall And Adherence To Cancer Risk Management Recommendations Among Patients With Germline Pathogenic Variants, Karishma Prakash Bharwani Mar 2024

Factors Impacting Genetic Test Result Recall And Adherence To Cancer Risk Management Recommendations Among Patients With Germline Pathogenic Variants, Karishma Prakash Bharwani

USF Tampa Graduate Theses and Dissertations

Only 20-60% of information from medical appointments is estimated to be retained of which about half is recalled accurately; however there remains limited information about recall following disclosure of inherited cancer genetic test results (GTR). We sought to evaluate recall of GTRs and the association of recall with adherence to recommended cancer risk management (CRM). Study participants were consented individuals with a confirmed germline pathogenic or likely pathogenic variant (GPV) in an inherited cancer predisposing genes for which there are CRM guidelines per the National Comprehensive Cancer Network (NCCN). Through information collected through self-reported surveys, adherence to CRM was defined …


Temporospatial Deep Learning Strategies For Prediction Of Disease Progression In Radiology, John D. Mayfield Mar 2024

Temporospatial Deep Learning Strategies For Prediction Of Disease Progression In Radiology, John D. Mayfield

USF Tampa Graduate Theses and Dissertations

While the fields of machine learning and medicine are deeply rooted in axiomatic scientific principles, there is an element of art that makes the practice imperfect, yet innately human. As the two fields have seen the greatest overlap in their collective history, there remains a chasm between them in terms of practical translation for the patients who desire and deserve personalized medicine. As presented in this dissertation, I and my collaborators have contributed to the groundwork for future exploration of predicting disease progression by identifying signals within sequential medical imaging to provide a temporospatial relationship upon which we can make …


Androgen Drives Melanoma Invasiveness And Metastatic Spread By Inducing Tumorigenic Fucosylation, Qian Liu Feb 2024

Androgen Drives Melanoma Invasiveness And Metastatic Spread By Inducing Tumorigenic Fucosylation, Qian Liu

USF Tampa Graduate Theses and Dissertations

Melanoma incidence and mortality rates are historically higher for men than women, with an estimated ~47% more new cases and twice the lethality in men in the US in 2023. Consistent with these discrepancies, emerging studies have highlighted the tumorigenic role of the male sex hormone androgen and its receptor (AR) in promoting melanoma aggressiveness. However, underlying cellular and molecular mechanisms and their precise pathological contributions are not well-defined. We recently discovered a sex-associated disparity in melanoma fucosylation, the post-translational modification of proteins with the dietary sugar L-fucose. Fucosylation, the conjugation of fucose moieties onto different glycan linkages on target …