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Articles 13981 - 14010 of 19641
Full-Text Articles in Entire DC Network
Drug Design, Biological Activity, And Metabolic Consequences Of Cytotoxic Platinum Compounds: Utilizing Fluorescent Tagging To Understand Drug Action And Metabolism, Brad Benedetti
Theses and Dissertations
Platinum drugs are among the most commonly used chemotherapeutics for the treatment of testicular, head and neck, ovarian, small cell lung, and colorectal carcinomas. Although the current set of platinum chemotherapeutics has proven somewhat successful, the overall success of platinum based drugs is limited due to acquired drug resistance and a limited range of tumor types that are treatable with the current regime. The development of novel cytotoxic platinum based compounds, both trans- and polynuclear, provides for the promising treatment of clinical platinum drug resistant tumors. While the cytotoxic activity of platinum drugs provides for a hopeful outlook, the ultimate …
Development And Application Of Nanomaterials For Analysis And Energy-Related Catalysis, Aize Li
Development And Application Of Nanomaterials For Analysis And Energy-Related Catalysis, Aize Li
Theses and Dissertations
Nanocomposites combine the merits of two or more nanomaterials and their development is a rapidly growing field. Two inorganic materials, SiO2 and TiO2, have long served as adaptable nanomaterials due to their non-toxic properties, low cost, high thermal and chemical stability. The goals of the research reported in this dissertation were to develop some novel nanocomposites based on these two nanomaterials, and to test their applications in environmental analysis and energy-related catalysis. Silica-supported Pt and Pt/Ru nanocatalysts were prepared using a template synthesis and applied in a direct methanol fuel cell. Various techniques such as EDS, TEM, XRD, UV-vis, and …
Silica Nanomatrix Effect On The Properties Of Encapsulated Molecules And Silica-Metal Nanoparticles For Bioapplications, Song Liang
Theses and Dissertations
Dye-doped silica nanoparticles (DDSNs) are one of the most popular fluorescent nanomaterials in bioapplications. The first chapter of this dissertation provides an overview of the DDSNs including general fabrication methods, unique properties, and current challenges. In the following three chapters, this dissertation is focused on two challenging areas of DDSN studies. One is the fundamental properties of dye molecules in the DDSNs, and the other is the design of new multifunctional DDSNs for bioapplications. In the first area, the effect of silica nanomatrix on the properties of doped molecules was investigated. Two important molecular properties were covered including the reaction …
Rural Adolescent Perceptions Of Quality Relationships, Jessica L. Semler
Rural Adolescent Perceptions Of Quality Relationships, Jessica L. Semler
Theses and Dissertations
The purpose of this qualitative study was to explore experiences and perspectives of rural adolescents regarding quality or healthy relationships. The Consensual Qualitative Research (CQR) method was used to analyze the qualitative data. Twelve eighth grade adolescent participants from three rural Midwestern junior high schools participated in the present study. Each participate completed an in-person, semi-structured interview. Specifically, questions were asked regarding participants meanings of healthy and unhealthy relationships, their perceptions of their current relationships with peers, family, and other adults, what they hoped for in future relationships, their ideas about why healthy relationships are important, and how they believe …
Impact Of Outcome Severity And Perceiver Similarity On Judgments Of Blame And Responsibility, Bridget L. Hanson
Impact Of Outcome Severity And Perceiver Similarity On Judgments Of Blame And Responsibility, Bridget L. Hanson
Theses and Dissertations
As the severity of an outcome increases, the responsibility assigned to the actor increases. This relationship interacts with actor-observer similarity such that similar others are typically assigned less responsibility in severe instances. These defensive attributions protect the perceiver from the conclusion that a similarly severe outcome could befall him/her. This study investigated the defensive attribution hypothesis as it relates to attributions of controllability, responsibility, and blame as well as punishment outcomes. Outcome severity and actor-perceiver similarity were manipulated using a child neglect paradigm in which a child is left unattended in a vehicle on a hot day. Within this context, …
Predictors Of Communication Delay In Children In The North Dakota Right Track Program, Carol A. Johnson
Predictors Of Communication Delay In Children In The North Dakota Right Track Program, Carol A. Johnson
Theses and Dissertations
Communication delays in infants and toddlers are significantly under- identified, prohibiting early intervention for many children and their families who might benefit from services. Recognizing communication delays early in life is critical for appropriate brain development to allow children to reach their potential. Researchers have sought to identify earlier and more accurate predictors of delays in communication development. Current approaches to the early identification of young children at risk for communication delay are not sufficiently sensitive to detect early stages of communication delay in all cases. There is a need to develop more sensitive methods for the early detection of …
Translocation Effects Of Lcrv Extracellular Surface Residues And Regulation Of Lcrg Binding To The T3ss Of Yersinia Pestis, Thomas A. Henderson
Translocation Effects Of Lcrv Extracellular Surface Residues And Regulation Of Lcrg Binding To The T3ss Of Yersinia Pestis, Thomas A. Henderson
Theses and Dissertations
Yersinia pestis, the etiological agent of the plague, immobilizes the host's innate immune response by translocating proteins called Yops (Yersinia outer proteins) into the eukaryotic cytoplasm using a type III secretion system (T3SS) injectisome known as the Yersinia secretion complex (Ysc). The T3SS injectisome, in many ways, resembles a hypodermic needle, composed of oligomeric rings with distinct areas responsible for different functions and many of these areas share homology to the flagellar T3SS basal body inner and outer membrane rings. Starting with the cytoplasmic region of the inner membrane known as the C-ring, this is an area where secretion is …
Sensory Modulation Disorder And Schizophrenia: Linking Behavioral Measures, Linda Olson
Sensory Modulation Disorder And Schizophrenia: Linking Behavioral Measures, Linda Olson
Theses and Dissertations
Schizophrenia is a devastating disorder affecting millions of people in the United States. Studies leading to new understanding of and intervention for this disorder are essential, as current interventions are minimally effective. The end result is high rates of re-hospitalization, impaired occupational performance and decreased community reintegration. According to the Diagnostic and Statistical Manual of Mental Disorders, symptoms of schizophrenia are categorized as positive or negative, with both types of symptoms impacting successful occupational engagement. Based on behavioral observations occupational therapists have hypothesized that this population may also experience sensory modulation disorder (SMD). Although electrophysiological studies support the presence of …
A Comparative Study Of Rotary Instrumentation Of The Maxillary First Premolar Buccal Root Utilizing Cone Beam Computed Tomography, Stephan Zigo
Theses and Dissertations
The study objective was to determine cementum-dentin wall thickness along the furcation groove in maxillary bifurcated first premolars after preparation with three successively larger, 0.04 tapered, nickel titanium rotary files. Pre-instrumentation and post-instrumentation imaging was accomplished utilizing Cone Beam Computed Tomography. All data was analyzed using an ANOVA. Instrumentation resulted in a significant reduction in dentin-cementum wall thickness (p < .001). At mid-groove, predicted dentin-cementum wall thickness (95% CI) was equal to or less than the proposed standard (0.50 mm) for apical file sizes 30, 35, and 40 respectively. Instrumentation of the mid-groove in maxillary first premolars reduces dentin-cementum wall thickness to levels that may be insufficient to ensure tooth integrity.
Accelerating Finite State Projection Through General Purpose Graphics Processing, Thomas Trimeloni
Accelerating Finite State Projection Through General Purpose Graphics Processing, Thomas Trimeloni
Theses and Dissertations
The finite state projection algorithm provides modelers a new way of directly solving the chemical master equation. The algorithm utilizes the matrix exponential function, and so the algorithm’s performance suffers when it is applied to large problems. Other work has been done to reduce the size of the exponentiation through mathematical simplifications, but efficiently exponentiating a large matrix has not been explored. This work explores implementing the finite state projection algorithm on several different high-performance computing platforms as a means of efficiently calculating the matrix exponential function for large systems. This work finds that general purpose graphics processing can accelerate …
Longitudinal Changes In The Corpus Callosum Following Pediatric Traumatic Brain Injury As Assessed By Volumetric Mri And Diffusion Tensor Imaging, Trevor Chuang Kuo Wu
Longitudinal Changes In The Corpus Callosum Following Pediatric Traumatic Brain Injury As Assessed By Volumetric Mri And Diffusion Tensor Imaging, Trevor Chuang Kuo Wu
Theses and Dissertations
Atrophy of the corpus callosum (CC) is a documented consequence of moderate-to-severe traumatic brain injury (TBI), which has been expressed as volume loss using quantitative magnetic resonance imaging (MRI). Other advanced imaging modalities such as diffusion tensor imaging (DTI) have also detected white matter microstructural alteration following TBI in the CC. The manner and degree to which macrostructural changes such as volume and microstructural changes develop over time following pediatric TBI and their relation to a measure of processing speed is the focus of this longitudinal investigation. As such, DTI and volumetric changes of the CC in participants with TBI …
Iain Baxter& And N.E. Thing Co.: A Study In Pop-Inflected Conceptual Art, Dennis Durham
Iain Baxter& And N.E. Thing Co.: A Study In Pop-Inflected Conceptual Art, Dennis Durham
Theses and Dissertations
The Canadian artist IAIN BAXTER&, known before 2005 as Iain Baxter, created an innovative Conceptual Art practice in the mid-60s that continues to make important contributions even today. He has maintained a strong collaborative element in his art, as witnessed by his role in the short-lived group IT (1965) and N.E. THING CO. (1966-1978)--an actual incorporated company consisting of BAXTER& and his first wife, Ingrid Baxter as chief officers--and by the addition of an ampersand to his legal name in 2005 to signify the open-ended quality of his work that relies on viewers‘ contributions to help determine its meaning. This …
Anesthesia Concerns With The Beach Chair Position, Jody Morlan
Anesthesia Concerns With The Beach Chair Position, Jody Morlan
Theses and Dissertations
The beach chair position has become a commonplace positioning technique for various procedures in the operating room. The purpose of this study was to review research related to the use of the beach chair position and general anesthesia along with the complications associated with it. There can be complications associated with this position that include venous air embolism, unrecognized cerebral hypoperfusion, blindness, and nerve injuries. The beach chair position causes many hemodynamic changes in the body; this is compounded when general anesthesia is used to further impact the stability of patients. Recent research has shown a death and three cases …
Honey In Healing: New Look At An Old Treatment, Tracy Jo Enger
Honey In Healing: New Look At An Old Treatment, Tracy Jo Enger
Theses and Dissertations
Chronic wounds such as pressure ulcers continue to be a difficult problem to manage, especially in the elderly populations. They are costly in terms of pain, as well as medical resources. The initiative Healthy People 2010 has set a goal at reducing the number of chronic wounds, more specifically pressure ulcers, by 50% in nursing home residents. (Porth & Matfin, 2009). Researchers are diligently attempting to find new, innovative, and cost-effective ways to manage chronic wounds. One solution may actually be an old remedy; honey. The purpose of this work is to provide healthcare workers with a review of the …
Methods And Effectiveness Of Psychoeducation: A Literature Review, Roxann Hackbarth
Methods And Effectiveness Of Psychoeducation: A Literature Review, Roxann Hackbarth
Theses and Dissertations
No abstract provided.
Evidence For The Need Of A Screening Tool To Recognize Perinatal Substance Abuse, Joeanna L. Larson
Evidence For The Need Of A Screening Tool To Recognize Perinatal Substance Abuse, Joeanna L. Larson
Theses and Dissertations
Perinatal substance abuse is a dangerous and detrimental problem faced by providers. Many questions arise when suspecting perinatal substance use. When is the appropriate time to screen? Are there clinical signs that providers can use to guide their decision? Is there the need for a tool that providers can use to guide their decisions? Screening for perinatal substance use is a difficult choice for providers. If a tool existed that would allow providers to screen for perinatal substance abuse based on clinical signs and symptoms, the judgment would lie in the evidence, and not with the provider. A screening tool …
Experimental Investigation Of Natural Fiber Reinforced Composite, Irene Samy Fahim
Experimental Investigation Of Natural Fiber Reinforced Composite, Irene Samy Fahim
Theses and Dissertations
There is a growing use of polymers in different applications worldwide. This phenomenon resulted in an enormous increase in the amount of plastic waste. These wastes have significant impacts on the environment including pollution and depletion of resources. Recycling plastic waste and reusing it helps in alleviating environmental degradation. The amount of recycled plastics all over the world not utilized is huge. U.S.A recycled 5.7% of the total plastics generated and Western Europe recycled 39% of total amount of plastics consumed [1]. This research studies the potential usage of virgin and recycled polymer reinforced with natural fiber such as rice …
Aligning Instructional Practices With Content Standards In Junior Secondary Schools In Indonesia, Rumtini Suwarno
Aligning Instructional Practices With Content Standards In Junior Secondary Schools In Indonesia, Rumtini Suwarno
Theses and Dissertations
This study examined the degree of alignment between instructional practices and national curriculum standards, which may vary as a function of teacher characteristics. Using self-reports from teachers about their experiences teaching the national curriculum standards, the study explored three aspects of the alignments: (1) topic coverage, (2) level of difficulty for teachers to teach, and (3) level of difficulty for students to learn. While topic coverage is determined by the percentage of the national curriculum standards topics taught during the year of 2008-2009, the level of teacher difficulty to teach and the level of student difficulty to learn are assessed …
Characterization And Genetic Analysis Of The Cellulolytic Microorganism Thermobifida Fusca, Yu Deng
Characterization And Genetic Analysis Of The Cellulolytic Microorganism Thermobifida Fusca, Yu Deng
Theses and Dissertations
Currently, one of the hurdles hindering efficient production of cellulosic biofuel is the recalcitrant nature of cellulose to hydrolysis. A wide variety of cellulase enzymes are found natively in microorganisms that can potentially be used to effectively hydrolyze cellulose to fermentable sugars. Thermobifida fusca is a high G-C content, thermophilic, gram-positive soil actinobacterium with high cellulolytic activity. The phenomenological and mechanistic parameters affecting cellulase activity were studied in T. fusca and two mechanisms have been found: 1) transcriptions of cellulase-related genes were not closely associated with measured differences in cellulase activity and 2) cellular energetics (intracellular ATP) correlated more closely …
The Relationship Of Physical Activity, Eating Behaviors, And Hunger Control To Weight Loss And Quality Of Life In Gastric Banding Patients, Nancy Baugh
Theses and Dissertations
Gastric banding as a weight loss surgery has increased in popularity in the United States since its approval by the Food and Drug Administration in 2001. Successful weight loss after weight loss surgery is most frequently defined as greater than 50 percent of excess weight loss (EWL). Systematic reviews show that the band is widely effective in achieving successful weight loss in most patients, however individual studies show more inconsistent outcomes. Although previous research supports gastric bypass surgery as having a positive effect on quality of life after gastric bypass, there is very little data to support this relationship in …
Examining Predictors Of Optimism In Adolescence: Internal And External Factors, E Chrissy Bulloch
Examining Predictors Of Optimism In Adolescence: Internal And External Factors, E Chrissy Bulloch
Theses and Dissertations
This study examined the relationship between parenting, adolescent personality, and adolescent optimism. Four hundred and eighty families with at least one adolescent child in the Seattle, Washington area completed a series of questionnaires assessing parenting style, personality, and optimism. Results from hierarchical regression analyses indicated that there is a small, yet significant, portion of the variance in optimism explained by parenting and personality individually, but that the relationship between optimism, parenting, and personality dynamics is far more complex than originally anticipated. Further research is needed to examine the nature of these relationships and to provide a more comprehensive understanding of …
Development Of Single-Chip Silicon Photonic Microcantilever Arrays For Sensing Applications, Weisheng Hu
Development Of Single-Chip Silicon Photonic Microcantilever Arrays For Sensing Applications, Weisheng Hu
Theses and Dissertations
Microcantilever arrays have been shown to be promising label-free nanomechanical sensing devices with high sensitivity. Two factors that affect the usefulness of microcantilevers in sensing scenarios are the sensitivity of the transduction method for measuring changes in microcantilever properties and the ability to create large compact arrays of microcantilevers. In this dissertation, we demonstrate that microcantilevers with an in-plane photonic transduction method are attractive because they maintain the sensitivity of the traditional laser beam reflection method while being scalable to simultaneous readout of large microcantilever arrays. First I demonstrate the integration of a compact waveguide splitter network with in-plane photonic …
Association Between Academic Performance And Electrocortical Processing Of Cognitive Stimuli In College Students, Mary Menn Wolf
Association Between Academic Performance And Electrocortical Processing Of Cognitive Stimuli In College Students, Mary Menn Wolf
Theses and Dissertations
Because event-related potentials (ERPs) can reflect individual differences in intellectual ability, individual differences in college grade-point average (GPA) may be associated with specific individual ERP waves, such as the P300. However, P300 amplitude is higher in women than in men and varies across the menstrual cycle, factors that could confound the association between GPA and ERPs. In this regard, our objective was to determine whether differences in GPA are reflected in ERPs while standardling for sex and menstrual phase. After participants provided informed consent, we obtained GPAs from 22 right-handed college students (11 male, age range 22 to 26 and …
De Novo Genome Assembly And Snp Marker Development Of Pyrenophora Semeniperda, Marcus Makina Soliai
De Novo Genome Assembly And Snp Marker Development Of Pyrenophora Semeniperda, Marcus Makina Soliai
Theses and Dissertations
Pyrenophora semeniperda (anamorph Drechslera campulata) is a necrotrophic fungal seed pathogen of a variety of grass genra and species, including Bromus tectorum, an exotic grass that has invaded many natural ecosystems of the U.S. Intermountain West. As a natural seed pathogen of B. tectorum, P. semeniperda has potential as a biocontrol agent due to its effectiveness at killing dormant B. tectorum seeds; however, few genetic resources exist for this fungus. Here, the genome assembly of a P. semeniperda isolate using 454 GS-FLX genomic and paired-end pyrosequencing techniques is presented. The total assembly is 32.5 Mb and contains …
Usage And Development Of Molecular Markers For Investigation Of The Population And Ecological Genetics Of Bromus Tectorum L., Keith R. Merrill
Usage And Development Of Molecular Markers For Investigation Of The Population And Ecological Genetics Of Bromus Tectorum L., Keith R. Merrill
Theses and Dissertations
This thesis includes two studies: The first examined patterns of neutral genetic diversity within Bromus tectorum L. across the IMW region, and uses patterns of microsatellite (SSR) genotype distribution to make inferences about the respective roles of adaptively significant genetic variation, adaptive phenotypic plasticity, and facultative outcrossing in the ongoing invasion and recent range expansion of B. tectorum. It has been previously demonstrated that, due to extremely low outcrossing rates, it is possible to characterize individual genotypes of this species using four SSR loci. We sampled 20 individuals from each of 96 B. tectorum populations (classified by region and …
Apparent Competition With Bromus Tectorum Through Pyrenophora Semeniperda Reduces Establishment Of Native Grasses, Katherine Temus Merrill
Apparent Competition With Bromus Tectorum Through Pyrenophora Semeniperda Reduces Establishment Of Native Grasses, Katherine Temus Merrill
Theses and Dissertations
Contributing to the success of Bromus tectorum in the Intermountain West may be a mechanism called apparent competition, which occurs when one species increases the pressure of a consumer on a second species. This indirect interaction has been documented only a few times in invasive plant systems, and never in a fungal pathosystem. We examined the effects of the invasive annual Bromus tectorum and predation by the seed pathogen Pyrenophora semeniperda on seedling emergence and survival for two native grasses (Pseudoroegneria spicata and Elymus elymoides), by manipulating B. tectorum densities and P. semeniperda inoculum loads in randomized plots. …
A Proteolytic Process To Simulate The Mechanics Of Disc Dengeration In Bovine Cadaveric Tissue, Timothy A. Bishop
A Proteolytic Process To Simulate The Mechanics Of Disc Dengeration In Bovine Cadaveric Tissue, Timothy A. Bishop
Theses and Dissertations
Purpose. The present work hypothesized that proteolytic dissolution of intervertebral discs could induce biomechanical change comparable to the change observed in natural disc degeneration. A method to do such could be utilized for in vitro research where intersample differences in geometry and chemical makeup render it difficult to compare and aggregate results into generalized conclusions.
Methods. Forty-one bovine coccygeal intervertebral discs were isolated with individual functional spinal units. Samples were loaded in three modes: compression/tension, flexion/extension, and axial rotation. The anulus fibrosus of each disc was injected with 200µl trypsin or fetal bovine serum (control) and incubated for an allotted …
Developing Methods To Assess The Potential Effects Of Global Climate Change On Deer Creek Reservoir Using Water Quality Modeling, Reed Earl Chilton
Developing Methods To Assess The Potential Effects Of Global Climate Change On Deer Creek Reservoir Using Water Quality Modeling, Reed Earl Chilton
Theses and Dissertations
To evaluate the potential impacts of future climate change on a temperate reservoir, I used a calibrated water quality and hydrodynamic model validated using three years of data (2007-2009) from Deer Creek Reservoir (Utah). I evaluated the changes due to altered air temperatures, inflow rates, and nutrient loads that might occur under Global Climate Change (GCC). I developed methods to study GCC on reservoirs. I produced Average Water Temperature Plots, Stratification Plots, and Total Concentration Plots. Average Water Temperature Plots show the sensitivity of the water temperature to various parameters. Stratification Plots quantify stratification length and strength as well as …
Culvert Roughness Elements For Native Utah Fish Passage: Phase I, Lindsay D. Esplin
Culvert Roughness Elements For Native Utah Fish Passage: Phase I, Lindsay D. Esplin
Theses and Dissertations
Culverts can increase stream velocities as a result of reduced waterway areas and prevent upstream passage of small non-salmonid fish such as the Native Utah Leatherside chub (Gila copei) and Longnose dace (Rhinichthyscataractae). To mitigate this problem, current culvert design standards for fish passage match sustained fish swim speeds with average cross sectional velocity through the culvert. Such policies dictate relatively large barrels and do not recognize the role of reduced velocity zones near culvert boundaries. Obstacles and streambed substrate create turbulent regions with lower velocity zones that can increase upstream fish passage. A comparison of …
Human Endogenous Sodium Pump Inhibitors Measurement, Source, Synthesis And Regulation, Jie Ma
Human Endogenous Sodium Pump Inhibitors Measurement, Source, Synthesis And Regulation, Jie Ma
Theses and Dissertations
The sodium pump (SP or Na+,K+-ATPase) is a membrane embedded protein complex that pumps 3 sodium ions out and 2 potassium ions into the cell per cycle and in so doing creates a cell membrane electrochemical potential. The membrane potential is critical for any functional cell. In the vasculature, reduction in the voltage potential causes vascular smooth muscle contraction and a narrowing of blood vessels (vasoconstriction) which can lead to increased blood pressure (hypertension). Substantial research over the past several decades has provided a vast amount of research on SP inhibitors, sometimes called endogenous digitalis-like factors (EDLF). Increased levels of …