Digital Commons Network^™

Receptor Influences In Girk Current Activation And Desensitization, Gyu Park

Theses and Dissertations

G protein-coupled receptors (GPCRs) are seven-transmembrane domain receptors that sense extracellular signal and activate intracellular signaling pathways. Metabotropic glutamate receptor 2 (mGluR2) is one of the GPCRs coupled to Gi/o proteins whose Gβγ subunits stimulate G protein-gated inwardly rectifying K+ channels (GIRKs). Previous experiments demonstrated that in planar lipid bilayer both active forms of G proteins [Gα (GTPγS-stimulated) and Gβγ subunits] were required to activate GIRK channels in the absence of the receptor, but surprisingly, the Gβγ subunit alone could activate GIRK channel in the presence of GPCR. Currently, it is not clear whether GPCRs play a role beyond catalyzing …

Interactive Software And Its Effects On Hostility, Warren Shya

Theses and Dissertations

The researcher will be exploring the relationship between violence in video games and the emotional responses to them. The goal of the study is to confirm the previous body of research that a short term increase in aggression and hostility exists after a violent video game is played. The study will also expand on the current existing body of data by examining other variables such as gender, age, typical time spent in a week playing videogames, overall familiarity with video games, the game genre that is normally played, and what consoles and systems are typically used to be played on. …

Rate Changes In Risky Behavior & The Role Of Sibling Influence, Julian Bajczyk

Theses and Dissertations

This study is based on research performed in 2006 by Laura Argys, Daniel Rees, Susan Averett, and Benjama Witoonchart. The 2006 study investigated relationship between the birth order and an adolescent's likelihood of engaging in certain risky behaviors. For the purpose of this study these behaviors include things like drug use, sexual activity and violent or antisocial offenses. The initial study found a trend implicating that adolescents with older siblings more likely to engage in certain risky behaviors than adolescents who did not have older siblings (eldest and only children). The Argys, et al. study used data collected from the …

Changes In Life History Within An Individual's Lifetime, Eric J. Billman

Theses and Dissertations

A central goal of life history theory is to understand the selective factors that generate the diversity of reproductive patterns observed in nature. Within lifetime changes in reproductive investment will determine an organism's fitness; however, this area of life history theory has received less attention than comparisons among population that characterize life history traits as a single population mean. Reproductive allocation can be affected by multiple cues; the integration of these cues across an organism's lifetime generates the diversity in life history strategies observed in nature. Life history studies should examine the interacting effects of multiple cues on life history …

Growth Of Age-0 Atlantic Menhaden (Brevoortia Tyrannus) In Two Tidal Freshwater Tributaries Of Chesapeake Bay, Peter M. Sturke

Theses and Dissertations

Few studies have described growth rates of age-0 Atlantic menhaden (Brevoortia tyrannus). Growth rates from tidal freshwater habitats of the Mattaponi and James Rivers, Virginia in 2009 were described and compared using otolith microstructural analyses. Larval tidal freshwater growth rates were significantly faster in the culturally eutrophic James River when compared to those collected from the Mattaponi River (p-value < 0.001). Elevated primary production within tidal freshwater habitats promotes favorable conditions for larval Atlantic menhaden growth. No differences between river habitats for juvenile growth rates were evident. Comparisons of age-0 growth rates to higher salinity habitats indicate that tidal freshwater habitats should be considered essential habitat for age-0 Atlantic menhaden.

Spinal Implant With Customized And Non-Linear Stiffness, Eric Ray Dodgen

Theses and Dissertations

There is a need for spinal implants that have nonlinear stiffness to provide stabilization if the spine loses stiffness through injury, degeneration, or surgery. There is also a need for spinal implants to be customizable for individual needs, and to be small enough to be unobtrusive once implanted. Past and ongoing work that defines the effects of degeneration on the torque rotation curve of a functional spinal unit (FSU) were used to produce a spinal implant which could meet these requirements. This thesis proposes contact-aided inserts to be used with the FlexSuRe™ spinal implant to create a nonlinear stiffness. Moreover, …

Adult Attachment: A Framework For Predicting Dating Patterns, Franklin Owen Poulsen

Theses and Dissertations

Although adult attachment has been the focus of a great deal of relationship research, few studies have attempted to examine how adult attachment style may be related to relationship initiation. This study investigates how adult attachment is associated with dating processes and patterns in a sample (N = 587) of college students at a private religious university. Results indicate that attachment anxiety and attachment avoidance are related to a pattern of being mostly dateless in a twenty-five week period. Furthermore, attachment avoidance but not anxiety is related to having fewer relationships in the period. Along with attachment avoidance and anxiety, …

Eddy Impaction As An Ash Deposition Mechanism: A Theoretical And Experimental Investigation, Minmin Li

Theses and Dissertations

The eddy impaction ash deposition model derived and validated in this document predicts eddy impaction rates as a function of turbulence intensity, boundary layer thickness, and gas velocity. The experimental apparatus introduces small particles (200 nm, 25 µm, and 500 µm diameter) into a gas stream flowing through a horizontal pipe (Re 2,300-8,000). The particles deposit on the pipe wall and the total mass of impacted particles provides a measure of collection efficiency. Experimental results indicate deposition velocity increases with Reynolds number, consistent with eddy impaction theory and based on increased turbulent energy. Eddy impaction also increases with particle size …

Marker Discovery In Allotetraploid Cotton Using 454 Pyrosequencing, Robert L. Byers

Theses and Dissertations

A narrow germplasm base and a complex allotetraploid genome have historically made the discovery of single nucleotide polymorphism (SNP) markers difficult in cotton (Gossypium hirsutum). We conducted a genome reduction experiment to identify SNPs from two accessions of G. hirsutum and two accessions of G. barbadense. Approximately 2 million sequence reads were assembled into contigs with an N50 of 508 bp and analyzed for SNPs. A total of 11,834 and 1,679 SNPs between the accessions G. hirsutum and G. barbadense, respectively, were identified with highly conservative parameters (a minimum read depth of 8x at each SNP …

Thin-Ideal Internalization, Body Misperception, And Their Association With Weight Control Behaviors Among Adolescent Girls, Erin Lindsey Moore

Theses and Dissertations

Negative body image and preoccupation with weight are the norm for most women and girls in Western society, despite their potentially harmful consequences for psychological and physical wellness. While we know that many in this population experience negative feelings towards their bodies, we do not know if their beliefs about their body size are accurate and what effect a correct or incorrect assessment of one's body size has in terms of actual behavior. I examine this question among adolescent girls using data from the 2002 Health Behaviors in School-Age Children Survey. With a sample of 2,784 girls between the ages …

Higher Education In Native American Communities: Who Graduates And Why?, Ramon Francisco Castillo Ii

Theses and Dissertations

In this case study, I examine the graduation patterns of students attending Chief Dull Knife College located on the Northern Cheyenne Reservation in Lame Deer, Montana. While comparing the characteristics of students attending this college with that of two-year colleges nationally and tribal schools throughout the nation, we begin to understand the unique situation that this community faces. With the use of logistic and linear regressions, I explored the characteristics of those who graduate and ask the question, who graduates and what makes them unique? This study found that the credits attempted per semester, the number of credits they earned …

Mechanical Characterization Of The Interspinous Ligament Using Anisotropic Small Punch Testing, Rachel Jane Bradshaw

Theses and Dissertations

Objective: The objective of this work was to characterize the nonlinear anisotropic material constitutive response of the interspinous ligament (ISL).

Methods: Cadaveric test samples of the interspinous ligament were tested using the anisotropic small punch test. The measured force-displacement response served as experimental input into a system identification optimization routine to determine the constitutive material parameters that replicated the measured material response.

Results: The constitutive behavior of the ISL is notably different from that reported for knee, shoulder, and hip ligaments. Specifically, the high collagen fiber content and unique collagen architecture provided a stiffer material response. The results from the …

Community Satisfaction, Community Attachment, Community Experience, Internet Use And Internet Access In Rural Utah Communities, Tisah M. Quarnberg

Theses and Dissertations

This study examines the impact of the Internet on rural community satisfaction, attachment and overall experience. With the geographic dispersion of social networks, the majority of the population has a greater need for long-distance social networking. The Internet has the potential to mitigate distance and connect social networks much faster than letter writing or face-to-face visits. While the Internet is available, to at least some extent, in rural communities in Utah, does it positively affect overall perceptions of community life? This study finds that this is not the case. There is a negative relationship between Internet use and community satisfaction …

The Professional Identity Development Of Gerontologists: An Experiential Learning Approach, Tracey Gendron

Theses and Dissertations

Professional identity is a complex construct that describes how an individual develops a sense of self-concept within a chosen profession. Professional identity refers to a self definition within a professional role based on attributes, beliefs, values, motives, and experiences (Ibarra, 1999). This study explored the relationships between the professional identity of gerontology graduates and age, career stage, student typology, occupation, and value of experiential learning both quantitatively and qualitatively. Survey results indicate that experiential learning opportunities provide a framework for all gerontology students to gain and apply the skills and knowledge necessary for professional identity development in the field of …

The Effects Of Β-Amyloid On Α7 Nicotinic Acetylcholine Receptors Expressed In Xenopus Oocytes, Malia L. Anderson

Theses and Dissertations

The exact mechanism and progression of Alzheimer's disease (AD) at present is not fully understood. In patients suffering from AD, damage to the hippocampal region and impairment of learning and memory is present. It is also known that a buildup of β-amyloid plaques occur in AD patients and that β-amyloid interacts with some subtypes of neuronal nicotinic acetylcholine receptors (neuronal nAChRs). These receptors are composed of five subunits. The most prevalent nAChR subunit composition through the brain as a whole is α7. Previous data produced from our lab suggests that α7 nAChRs are also one of the most prevalent subunits …

Characterization Of The Mechanical Response Of The Lumbar Spine, Shannon Alisa Zirbel

Theses and Dissertations

The primary objective of this research is to associate lumbar segmental mechanical response with intervertebral disc degeneration under physiologic testing conditions. Because no mathematical model exists for lumbar spine segmental rotations, a portion of this thesis evaluates potential methods for curve fitting the torque-rotation curves. The Dual Inflection Point (DIP) Boltzmann equation was developed during the course of this research and is presented here as a method for fitting spinal motion data wherein a physical meaning can be assigned to each of the model coefficients. This model can tell us more about the effects of degeneration, testing conditions, and other …

Comparing The Effects Of Two Forms Of Dynamic Corrective Feedback On Four Characteristics Of English Language Learner Writing, Judson Mc Kay Hart

Theses and Dissertations

Particular English language learners have a need to demonstrate high levels of accuracy in their written and spoken language production. Dynamic corrective feedback (dynamic CF) has been shown to facilitate L2 learner written accuracy attainment through providing manageable, meaningful, timely and constant feedback on authentic and frequent written language production. The research of this thesis examined the benefits of altering the dynamic CF model to be responsive to students' spoken production rather than solely their written production and measured the impact this adaptation would have on the established benefits of the instructional strategy on students' gains in written accuracy. The …

The Molecular Mechanism Of Migraine, Kristin Dawn Watson

Theses and Dissertations

Migraine is a common, episodic neurological disorder that includes headache, nausea and hypersensitivity to sensory stimuli. During the headache phase of migraine, migraine patients can be especially hypersensitive to thermal stimuli. The unpredictable and episodic nature of migraine makes it difficult to treat and much of the mechanism of migraine has yet to be elucidated. A T44A substitution in casein kinase 1δ is inherited with migraine with aura. A transgenic mouse model suggests that animals with this mutation exhibit increased sensitivity to thermal stimuli after injection with nitroglycerin (NTG). We performed behavior assays that measure animal responses to thermal stimuli, …

Structures Of Poliovirus And Antibody Complexes Reveal Movements Of The Capsid Protein Vp1 During Cell Entry, Jun Lin

Theses and Dissertations

In the infection process, native poliovirus (160S) first converts to a cell-entry intermediate (135S) particle, which causes the externalization of capsid proteins VP4 and the N-terminus of VP1 (residues 1-53). The externalization of these entities is followed by release of the RNA genome, leaving an empty (80S) particle. Three antibodies were utilized to track the location of VP1 residues in different states of poliovirus by cryogenic electron microscopy (cryo-EM). "P1" antibody binds to N-terminal residues 24-40 of VP1. Three-dimensional reconstruction of 135S-P1 showed that P1 binds to a prominent capsid peak known as the "propeller tip". In contrast, our initial …

Examining The Mediating Factors Between Religiosity And Pornography Use In Adolescents, Michael A. Steelman

Theses and Dissertations

The purpose of this study was to examine relations between adolescent religiosity and pornography use, and the roles of self-regulation, attitudes towards pornography, and social control as mediators of these relations. It was hypothesized that religiosity would protect adolescents from exposure to pornography by increasing their self-regulation capacity, their conservative attitudes about pornography, and their perceived social norms regarding pornography. The sample consisted of 419 adolescents (ages 15 - 18 years; M age = 15.68, SD = .98; 56% male) recruited online from across the U.S. Participants completed an online survey. All variables were bivariately associated as expected. Path models …

Reproductive Success And Soil Seed Bank Characteristics Of Astragalus Ampullarioides And A. Holmgreniorum (Fabaceae): Two Rare Endemics Of Southwestern Utah, Allyson B. Searle

Theses and Dissertations

Astragalus ampullarioides and A. holmgreniorum are two rare endemics of southwestern Utah. Over two consecutive field seasons (2009-2010) we examined pre-emergent reproductive success, based on F/F and S/O ratios, from populations of both Astragalus ampullarioides and A. holmgreniorum, estimated the density of the soil seed bank of A. holmgreniorum as a measure of potential post-emergent reproductive success, and estimated seed persistence within the soil seed bank. Fruit/flower (F/F) ratios and seed/ovule (S/O) ratios varied significantly between populations and among years in both species, and showed low reproductive output in both taxa. In Astragalus ampullarioides F/F and S/O were 0.06±0.01 …

Dismissed With Prejudice: Gender Inequality In The Utah Legal Market, Collin Read Flake

Theses and Dissertations

With the increasing feminization of the legal profession in the United States over the last half century, past research has documented the prevalence and transformation of gender inequality in law firms. However, relatively little is known about gender inequality in small, conservative legal markets like Utah. This thesis examines data from the 2008-2009 Utah Attorney Advancement and Retention Survey. The analyses indicate that relative to their male colleagues, women earned less in 2007 and are less likely to procure higher quality job assignments than their peers. The most promising explanations for these disparities include employment sector, gender and motherhood statuses, …

Novel Ion Trap Made Using Lithographically Patterned Plates, Ying Peng

Theses and Dissertations

A new approach of making ion trap mass analyzers was developed in which trapping fields are created in the space between two ceramic plates. Based on microfabrication technology, a series of independently-adjustable electrode rings is lithographically patterned on the facing surfaces of each ceramic plate. The trapping field can be modified or fine-tuned simply by changing the RF amplitude applied to each electrode ring. By adjusting the potential function applied to the plates, arbitrary trapping fields can be created using the same set of ceramic plates. Unlike conventional ion traps, the electrodes of planar ion traps have a non-equipotential surface, …

Genome Snapshot And Molecular Marker Development In Penstemon (Plantaginaceae), Rhyan B. Dockter

Theses and Dissertations

Penstemon Mitchell (Plantaginaceae) is one of the largest, most diverse plant genera in North America. Their unique diversity, paired with their drought-tolerance and overall hardiness, give Penstemon a vast amount of potential in the landscaping industry—especially in the more arid western United States where they naturally thrive. In order to develop Penstemon lines for more widespread commercial and private landscaping use, we must improve our understanding of the vast genetic diversity of the genus on a molecular level. In this study we utilize genome reduction and barcoding to optimize 454-pyrosequencing in four target species of Penstemon (P. cyananthus, …

Risk Factors Associated With Urinary Tract Infections And Patient Education, Natalie R. Royal

Theses and Dissertations

No abstract provided.

Rural Hospital System Affiliations And Their Effects On Hospital Economic Performance, 2004-2008, Mark Swofford

Theses and Dissertations

The formation of multi-hospital systems represents one of the largest structural changes in the hospital industry. As of 2008, system affiliated hospitals outnumbered stand alone hospitals 2511 to 2167 and the percentage of system affiliated rural hospitals has increased dramatically from 24.8% in 1983 to 42.2% in 2008 (based on AHA data for non-federal acute care general hospitals). The effects of system membership on hospital performance have been of great interest to health care researchers, but the majority of research on multi-hospital systems has either focused exclusively on urban facilities or pooled urban and rural facilities in the same sample, …

Integration Of Micropore And Nanopore Features With Optofluidic Waveguides For Single Particle Sensing, Matthew R. Holmes

Theses and Dissertations

This dissertation outlines the research and development of ground-breaking nanometer sized openings (nanopores) integrated with an on-chip optofluidic platform. This platform represents a significant advancement for single nanoparticle sensing. In this work specifically, the integrated optofluidic platform has been used to electrically and optically filter and detect single nanoparticles using ionic current blockade and fluorescence experiments. The correlation of electrical and optical signal has provided the highest sensitivity single nanoparticle measurements ever taken with integrated optofluidic platforms. The particular optofluidic platform used for this work is an antiresonant reflecting optical waveguide (ARROW). ARROW hollow and solid core waveguides are interference …

Devices And Methods For Electro-Physical Transport Of Dna Across Cell Membranes, Quentin Theodore Aten

Theses and Dissertations

A novel method for charged macromolecule delivery, called nanoinjection, has been developed at Brigham Young University. Nanoinjection combines micro-fabrication technology, mechanism design, and nano-scale electrical phenomenon to transport exogenous DNA across cell membranes on a nano-featured lance. DNA is electrically accumulated on the lance, precision movements of microelectromechanical systems (MEMS) physically insert the lance into cell, and DNA is electrically released from the lance into the cell. Penetration into the cell is achieved through a two-phase, self-reconfiguring metamorphic mechanism. The surface-micromachined, metamorphic nanoinjector mechanism elevates the lance above the fabrication substrate, then translates in-plane at a constant height as the …

Differential Glial Cell Responses In The Dentate Gyrus In Young Adult And Aged Brains Following Traumatic Brain Injury, Christoher Shin

Theses and Dissertations

Traumatic brain injury (TBI) affects 3 out of every 1000 Americans each year, and is the leading cause of morbidity and mortality after trauma, accounting for as many as 56,000 deaths per year (Dutton and McCunn, 2003). The Centers for Disease and Control and Prevention found that TBI most commonly occurs in adolescents and young adults aged from 15 to 24 years and in the elderly (75 years and older). Following injury, the secondary injury begins almost immediately after the primary injury and is the result of a number of cascades where once activated, exacerbate the already altered homeostasis of …

Critical Components Of Suicide Prevention Programs For Colleges And Universities: A Delphi Study, Colleen A. Johnson

Theses and Dissertations

Despite debate over whether or not college student suicide rates are greater or less than similar age groups not enrolled in higher education, the rates of college students experiencing suicide ideation, attempting suicide, and successfully committing suicide are indeed rising. A steady increase in these rates over the last 15 years is evidence that this is an issue of great concern that needs further investigation and action. This study was focused on investigating what college and university counseling center employees with expertise in the development and implementation of suicide prevention programs believe to be critical components of an all-encompassing, workable …