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Growing Up In Ireland: Factors Impacting Sleep Patterns Of Preterm Infants, Joanne Fallon

Theses and Dissertations

GROWING UP IN IRELAND: FACTORS IMPACTING SLEEP PATTERNS OF PRETERM INFANTS

By Joanne Fallon MS, OT, PhD

A dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University

Virginia Commonwealth University, 2015.

Major Director: Shelly J. Lane, PhD, Professor, Department of Occupational Therapy

Preterm infants represent the largest child patient group in the European Union (EU), accounting for 5.5-11.4% of all births (European Foundation for the Care of Newborn Infants, 2011b). Preterm birth is defined as birth prior to 37 weeks gestation. Infants born late preterm (34-36 weeks) are considered more …

Fluorescence Imaging Of Analyte Profiles In An Inductively Coupled Plasma With Laser Ablation As A Sample Introduction Source, Lance Moses

Theses and Dissertations

Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) has risen to among the top tier techniques for the direct analysis of solid samples. However, significant problems remain that must be solved to achieve the full analytical potential of LA-ICP-MS. Inefficient conversion of aerosol to ions within the ICP or transmission through the MS interface may decrease precision, sensitivity, and/or accuracy. Although fundamental mechanisms that govern ion production and transmission have been studied extensively in solution-nebulization (SN) ICP-MS instruments, significant gaps in our understanding remain. Furthermore, it is unclear to what extent differences between the aerosols generated during SN and LA …

Inn Nems And Heterojunction Devices For Sensing Applications, Alina Wilson

Theses and Dissertations

Recent research trends in chemical and biological sensing have been geared toward developing molecular sensor devices that are fast, inexpensive, miniaturized, have low power consumption and are portable. The performance of these devices can be dramatically improved by utilizing multimodal detection techniques, new materials and nanofabrication technologies. To develop such sensor devices, we utilized Indium Nitride (InN) nanowires (NWs) to fabricate nanoelectromechanical system (NEMS) based sensors and Graphene/InN NW heterojunctions, and InN thin films to fabricate Graphene/InN thin film heterojunction based sensors. InN NWs, which exhibit interesting properties including high carrier density, superior electron mobility, strong surface charge accumulation, and …

A Silylation-Based Kinetic Resolution Of Hydroxy Lactones And Lactams With Subsequent Mechanistic Investigations, Robert W. Clark

Theses and Dissertations

The work contained herein focuses on the methodology and design of new reactions for the production of stereoenriched compounds. The primary focus of research discussed is kinetic resolution, a classic and powerful methodology for the separation of a single enantiomer from a racemic mixture. In 2011, a silylation-based resolution catalyzed by a chiral isothiourea produced synthetically useful selectivity factors for mono-functional secondary alcohols. In chapter 2, this methodology was subsequently expanded to include α-hydroxy lactones with selectivity factors up to 100. This study resulted in the most selective reaction reported to date for the aforementioned silylation-based resolution. In addition to …

Dissolved And Particulate Phosphorus Distributions And Elemental Stoichiometry Throughout The Chukchi Sea, Meryssa Piper

Theses and Dissertations

As the only gateway of material, particularly nutrients, from the Pacific to the Arctic Ocean, the biological and chemical transformations that occur within the Chukchi Sea are critical for understanding Arctic ecosystems. This study examines the biogeochemical cycling of the macronutrient phosphorus (P) relative to carbon and nitrogen in the eastern Chukchi Sea during the ICESCAPE’s mission. Sea ice and water column dissolved and particulate phosphorus samples were collected during two summer expeditions in 2010 (n=593) and 2011 (n=989). Despite being a landlocked marginal sea, the P pool present within the Chukchi Sea was substantially modified by biological processes with …

Patient And Provider Characteristics And Practice Patterns Of Primary Care Physicians Of Weight-Related Counseling, Kolby T. Redd

Theses and Dissertations

Background: The United States Preventive Services Task Force (USPSTF) recommends three types of health education counseling for use in primary care practices for adult, obese patients. While these recommendations are well known, a low percentage of physicians provide this counseling to their patients on a consistent basis. There are inconsistencies in past studies in regards to what aspects of the health encounter influence the likelihood of receiving health education counseling during a primary care visit. The objective of this study was to (1) investigate the patterns of these three types of counseling occurring within primary care practices and to …

Factors Contributing To Interannual Variability In The Abundance Of Bay Anchovy (Anchoa Mitchilli) Larvae, Steven B. Vega Jr.

Theses and Dissertations

Coastal ecosystems have been subject to increasing stressors over recent decades due to coastal development, human population growth, and climate change. Improving scientific understanding of the environmental factors which influence the productivity of fish populations in coastal ecosystems is vital to their prudent management, especially as the potential influence of anthropogenic climate change grows. Estuaries serve as critical habitats for many fishes of primary ecological, economic, and recreational importance. One such fish, the planktivorous Bay Anchovy (Anchoa mitchilli), is abundant along the Atlantic and Gulf coasts of the US and is a key prey resource for many estuarine and coastal …

H.P. Lovecraft & The French Connection: Translation, Pulps And Literary History, Todd David Spaulding

Theses and Dissertations

Weird fiction writer H. P. Lovecraft captured the zeitgeist of the modernist movement, despite his association with popular fiction. Lovecraft’s post-mortem climb from the margins of the American literary system to its center is indicative of his influence on “mass” and “elite” cultures alike in the second half of the twentieth century and onward. Lovecraft’s influence is not restricted to American culture, but it spread like an airborne virus to other cultures, and to France in particular. His imaginative weird fiction, a unique combination of horror and science fiction, has been translated into more than 25 languages from Bengali to …

Making The Irrational Rational: Nietzsche And The Problem Of Knowledge In Mikhail Bulgakov's The Master And Margarita, Brendan Mooney

Theses and Dissertations

The goal of this thesis is twofold: first, to explore the influence of the German philosopher Friedrich Nietzsche on the Russian writer Mikhail Bulgakov, and second, to use Nietzsche’s unpublished essay “On Truth and Lies in a Nonmoral Sense” (written 1873) to examine the problem of knowledge in Bulgakov’s The Master and Margarita (written 1928-1940).

In existing scholarship on Bulgakov’s masterpiece The Master and Margarita, the novel’s epistemological underpinnings are a topic that remains relatively unacknowledged. The “supernatural” element presents an opportunity to examine the manner in which man interacts with unprecedented phenomena, that is, phenomena that do not …

An Examination Of The Perception Of School Administrators On The Effectiveness Of Freshman Academies On The Academic Achievement Of African American Males, Willie Matthews

Theses and Dissertations

The significant impact of transitioning to ninth grade has necessitated the need to examine the effects of the secondary school structure on African American males. These students were often assumed to be capable of functioning and maintaining personal accountability within their new, less structured environment, as opposed to the structured setting they encountered in middle school (Ellerbrock & Kiefer, 2013). As a result, these adolescents encountered increased challenges often resulting in greater challenges and lack of motivation that does not cater to their learning and developmental needs (Ellerbrock & Kiefer).

Bethel (2012) indicated that environmental characteristics of the school setting …

Investigation Of Laminar Convective Heat Transfer And Pressure Drop Of Sio2 Nanofluid In Ducts Of Different Geometries, Sunday Oluwafemi Hassan

Theses and Dissertations

Engineers are seeking alternatives to conventional heat transfer fluids and in an attempt to improve their thermal transport properties, they added thermally conductive solids into the conventional fluids resulting in a fluid called nanofluid. Nanofluid was suggested as an alternative solution to the problem and many publications reported its potential for heat transfer enhancement. This thesis describes the experimental study of 9.58% by vol. silica/water nanofluid flow through different flow geometries which are circular, hexagonal and rectangular ducts of close hydraulic diameter. The experiments are performed at uniform heat flux condition. The aim of this thesis is to determine experimentally …

Corticotropin-Releasing Factor Facilitates Epileptiform–Activity In The Entorhinal Cortex Via Crf2 Signaling Mechanisms, Lalitha Kurada

Theses and Dissertations

Temporal lobe epilepsy (TLE) is characterized by hyperexcitability of limbic structures. The entorhinal cortex (EC) is involved in the initiation and maintenance of TLE. Layers II and III of the EC in particular are hyperexcitable and are more susceptible to epileptogenesis. TLE is influenced in a complex manner by the stress-released epileptogenic neuropeptide, corticotropin-releasing factor or hormone (CRF/CRH). Nevertheless, the action site and underlying mechanisms of CRF in epilepsy are not fully understood. Here we found that the EC expresses high levels of CRF and CRF2 receptors without the expression of CRF1 receptors. CRF increased the frequency of picrotoxin (PTX)-induced …

Reconceptualizing Privacy: An Examination Of The Developing Regulatory Regime For Facial Recognition Technology, David James Potter

Theses and Dissertations

The National Telecommunications and Information Administration have convened a series of meetings to create a voluntary code of conduct for the commercial use of facial recognition technology. This research asks and answers three questions related to the creation of the voluntary code of conduct: 1) How is the regulatory regime of FRT emerging in the U.S.? 2) What are the roles of the various stakeholders in shaping the commercial regulation of FRT? 3) How does FRT challenge our current conceptions of privacy? Data has been gathered to answer these questions using participant observation and semi-structured interviews. The data was analyzed …

N-Cadherin Expression And Emt Progression In Arsenic- And Cadmium-Transformed Urotsa, Elizabeth Sandquist

Theses and Dissertations

Environmental agents are common causes of bladder cancer. Specifically, arsenic (As3+) and cadmium (Cd2+) are known carcinogens implicated in the development of bladder cancer. Previous studies from our laboratory have shown that As3+ and Cd2+ can cause malignant transformation of normal immortalized bladder urothelial cells, which can form tumors when injected subcutaneous or intraperitoneal into nude mice. Microarray analysis of repeated metal transformation in parallel revealed that N-cadherin was the most upregulated gene in As3+ transformants, and a top induced gene in Cd2+-transformed cells. The switch from E-cadherin to N-cadherin is a well-known indicator of the epithelial-to-mesenchymal transition occurring in …

Prevalence And Distribution Of Ranavirus, Chytrid Fungus, And Helminths In North Dakota Amphibians, Melanie Paige Firkins

Theses and Dissertations

Worldwide reports of population declines and extinctions of amphibians have continued for at least two decades. Factors frequently reported in association with these declines include habitat loss, infectious diseases, and environmental degradation. Three sources of disease have been a concern for amphibians: chytrid fungus, Ranavirus, and some helminth parasites. Much of the existing reporting on disease results from anecdotal accounts associated with localized outbreaks, but understanding the scope and dynamics of infectious agents in host populations requires a regional perspective. My objectives were to estimate geographic distribution and prevalence of Ranavirus, chytrid fungus, and helminths in amphibians across the state …

Characterization Of Dopamine Transporter Palmitoylation, Danielle Elizabeth Rastedt

Theses and Dissertations

The dopamine transporter (DAT) is an integral membrane protein that mediates the reuptake of synaptic dopamine and thus regulates the spatio-temporal dynamics of dopaminergic neurotransmission. DAT is also the target of powerful addictive psychostimulants, including cocaine and methamphetamine that resulted in dysregulation of dopaminergic signaling. Complex control of DAT is exerted by various regulatory processes, including posttranslational modifications. We previously found that DAT is palmitoylated via the addition of a 16-carbon palmitic acid moiety to Cys 580. Pharmacological and mutagenic studies determined that depalmitoylation conditions led to reductions in Vmax and transporter levels, suggesting palmitoylation controls one or more functions …

The Unique N- And C-Terminal Domains Of Metallothionein-3 Influence The Growth And Differentiation Of Breast Cancer Cells, Brent Jeffrey Voels

Theses and Dissertations

Toxic insult from the heavy metal cadmium is known to induce the expression of metallothioneins (MT) which are cysteine-rich heavy metal binding proteins six to seven kilodaltons in size. Previous research demonstrates that over-expression of MT-3 occurs in the majority of breast cancers and is associated with poor patient outcome. Furthermore, MT-3 has been shown to inhibit the growth of breast cancer and prostate cancer cell lines. Studies have shown that the MT-3 protein contains 7 additional amino acids that are not present in any other member of the MT gene family, a 6 amino acid C-terminal sequence and a …

Dysregulation Of Micrornas In Blood As Biomarkers For Diagnosing Prostate Cancer, Rhonda W. Daniel

Theses and Dissertations

Prostate cancer is the most common noncutaneous cancer among men, yet current diagnostic methods are insufficient and more reliable diagnostic markers need to be developed. The answer that can bridge this gap and enable more efficient diagnoses may lie in microRNAs. These small, single stranded RNA molecules impact protein expression at the translational level and regulate important cellular pathways. Dysregulation of these small RNA molecules can have tumorigenic effects on cells and lead to many types of cancers.

Currently the Prostate-Stimulating Antigen (PSA) is used as a diagnostic marker for prostate cancer. However, many factors can elevate PSA levels such …

Synthesis, Surface Functionalization, And Biological Testing Of Iron Oxide Nanoparticles For Development As A Cancer Therapeutic, Stanley E. Gilliland Iii

Theses and Dissertations

Iron oxide nanoparticles are highly researched for their use in biomedical applications such as drug delivery, diagnosis, and therapy. The inherent biodegradable and biocompatible nanoparticle properties make them highly advantageous in nanomedicine. The magnetic properties of iron oxide nanoparticles make them promising candidates for magnetic fluid hyperthermia applications. Designing an efficient iron oxide nanoparticle for hyperthermia requires synthetic, surface functionalization, stability, and biological investigations. This research focused on the following three areas: optimizing synthesis conditions for maximum radiofrequency induced magnetic hyperthermia, designing a simple and modifiable surface functionalization method for specific or broad biological stability, and in vitro and in …

Hif-Independent Responses In Hypoxia, Divya Padmanabha

Theses and Dissertations

The adaptive response to hypoxia is accompanied by widespread transcriptional changes that allow for prolonged survival in low oxygen. Many of these changes are directly regulated by the conserved hypoxia-inducible factor-1 (HIF-1) complex; however, even in its absence, many oxygen-sensitive transcripts in Caenorhabditis elegans are appropriately regulated in hypoxia. To identify mediators of these non-HIF-dependent responses, I established a hif-1 mutant reporter line that expresses GFP in hypoxia or when worms are treated with the hypoxia mimetic cobalt chloride (cobalt chloride). The reporter is selective and HIF-independent, in that it remains insensitive to a number of cellular stresses, but is …

Heterosandwich Assay Of Nicotinic Acetylcholine Receptors, Augustine J. Pagan Iv

Theses and Dissertations

Using the technology afforded by Winschel et al., cyclen-1, a high affinity, strong complexation agent for 8-hydroxypyrene-1,3,6 trisulfonate and derivatives, a new assay has been developed for fluorescently labeling proteins of interest (POIs). Ligation of the endogenous ligand for nicotinic acetylcholine receptors (nAChRs), acetylcholine, using click chemistry afforded the triazole derivative of an alkynyl-acylcholine (compound 1) with 8-azidopyrene-1,3,6 trisulfonate (compound 2). Liposomes encapsulated with Rhodamine B were used to strengthen the initial fluorophore response of compound 2, using an anchored form of cyclen-1 complex. Using a palmitoyl tail as the lipophilic moiety for liposomal amplification, the …

Fostering Creativity Skills In Online Mba Programs: Perceptions Of Mba Alumni, Mark D. Orlando

Theses and Dissertations

With companies seeking to increase organizational efficiency while promoting prosperous growth, creativity has become one of the most important leadership qualities sought after by employers. This has put a demand on Masters of Business Administration (MBA) graduates to possess creative skills, as well as a dependency for MBA students to acquire a quality MBA education. Although business education has entered into new domains of online learning, the criticism remains that business education does little to foster or strengthen students' creativity skills. Thus, with the evolution of online education arises a need to research the effectiveness of creativity within these new …

Resiliency Of Secondary Principals In Southern California: A Phenomenological Study, Suzanne M. Webb

Theses and Dissertations

The purpose of this qualitative phenomenological research study was two-fold: (a) investigate the lived experiences of secondary principals with more than 5 years’ tenure in high performing public schools in Southern California as they relate to resiliency, and (b) explore their lived experiences as they relate to stress and coping. Studies show that secondary principals rarely stay at the same school site for longer than 3-5 years. Since known research on principal resiliency concerns primarily high poverty or low performing schools, a need was found to examine why secondary principals in high performing public schools stay longer than 5 years. …

Exploring Themes Of Moral Injury And Resilience Among Women In A Transitional Living Center, Kristen A. Otte

Theses and Dissertations

Moral injury is a construct that has primarily been studied in war veterans, police officers, and military nurses. It involves a change in an individual's expectations about their own or another's behavior in the face of events involving a violation of their beliefs about themselves, observation of unethical behavior by others, and/or witnessing human suffering that violates beliefs in the goodness of humanity. Research indicates that moral injury involves at least five major themes: betrayal and trust issues; social problems; spiritual/existential issues; psychological symptoms; and self-deprecation. Moral injury represents an important, emerging area of study that may facilitate a better …

The Relationship Between Second-Generation Antipsychotic Medication Adherence And Negative Symptoms In First-Episode Schizophrenia, Elisha R. Agee

Theses and Dissertations

Adherence to psychotropic medication is a critical aspect of treatment for the management of psychotic disorders. While the literature on the need for medication adherence is extensive, little research has explored the relationship between the negative symptoms of psychosis and medication adherence. Since negative symptoms are enduring, stable, and strongly correlated with poor outcome, it is vitally important for research to explore the role of negative symptoms in regards to adherence to psychotropic medication. Given its potentially significant consequences for treatment interventions, the purpose of this study was to contribute to the exceedingly limited body of research exploring the relationship …

Development Of The Athlete: A Resource Manual For Clinicians Working With Elite Adolescent Male Athletes, Kenneth D. Hartline

Theses and Dissertations

Over recent decades, adolescent athletic participation has grown in the United States. The rise in participation means that mental health clinicians who work with adolescents are likely increasingly coming in contact with young athletes facing issues directly related to sports. The issues facing adolescent athletes create additional challenges that should be addressed in treatment to improve overall psychological well-being and to promote healthy development. In order to best meet the general mental health needs of these clients, clinicians need to be aware of the unique stressors and issues they frequently face. A resource manual was created to guide clinicians working …

Women Leaders In Healthcare: Going Beyond The Glass Ceiling, Cortney Baker

Theses and Dissertations

Between 2004 and 2014, healthcare jobs were among the fastest growing occupations in the U.S., adding 4.3 million positions and expected job growth of 30.3%. The majority of the healthcare workforce is overwhelmingly dominated by women. However, when it comes to leadership positions, especially executive and board levels, females are considerably underrepresented. Interestingly, though, women, more than men, are reported to demonstrate traits such as transparency, compassion, and support for teamwork, which would benefit organizations as they venture into the future of healthcare delivery. In recent years, women have made minimal entry into the highest ranks of managerial positions of …

Survey Says: An Analysis Of The Degree Of Impact Of The Beginning Teacher Support And Assessment Program On Classroom Practices, Kenney Shresia Deon Fontenot

Theses and Dissertations

Every year, thousands of teachers participate in California's Beginning Teacher Support and Assessment program in order to complete the requirements needed to obtain a clear teaching credential. Within this program lie various facets of support that serve the needs of beginning teachers and aid them in transitioning from university theory to classroom practice. Despite the long-standing existence of the BTSA program and the changes that have taken place since its development in 1992, the need exists for closer analysis of the programs effect on teaching practices and student achievement. This quantitative study analyzes (a) the degree of impact on classroom …

Relationship Between Negative Social Reactions To Sexual Assault Disclosure And Mental Health Outcomes Of Ethnically Diverse Female Survivors, Dehnad Hakimi

Theses and Dissertations

Negative social reactions that sexual assault survivors receive upon disclosure have been correlated with psychological distress such as posttraumatic stress disorder, depression, and problem drinking. However, the impact of ethnicity in the relationship between unsupportive reactions to assault disclosure and the psychological sequelae remains unclear. Using hierarchical linear regressions and a sample of 665 African-American, Latina, and Caucasian female adult sexual assault survivors, the present study examined the role of ethnicity in that relationship. The results suggest that ethnicity moderates the influence of negative disclosure reactions on psychological symptoms, however, the moderation impact was not similar across races and psychological …

Identified Enrollment Management Practices In The California State University System, Ginger Q. Reyes

Theses and Dissertations

This study focused on the California State University system's enrollment management activities. For schools in California who rely on state funds, managing enrollment has to be balanced with competing campus priorities, limited resources, volatile economic times, and the primary mission of the system which is serving students whose goal is to achieve a college degree. Hossler and Bean (1990) defined enrollment management as the activities a campus conducts and how it organizes itself in order to influence student enrollment. Enrollment management components consist of marketing, admissions and recruitment, academic advising, career planning and placement, academic assistance programs, institutional research, orientation, …