Digital Commons Network^™

Sequential Transformation Of Polycythemia Vera To Myelofibrosis And Kmt2a-Rearranged Acute Myeloid Leukemia Treated With Revumenib: A Rare Case Of Clonal Evolution, Christopher M. Ahmad, Rae-Anne Kastle, Lara Zargarian, Yasmeen Sawalha, Samir Dalia

Student Publications

Transformation of polycythemia vera (PV) into post-polycythemic myelofibrosis (MF) and subsequently acute myeloid leukemia (AML) represents one of the most aggressive trajectories among myeloproliferative neoplasms (MPNs). Post-MPN AML carries a median survival of approximately six months, particularly among older adults with adverse cytogenetics. We report the case of a 73-year-old man with JAK2-positive PV diagnosed in 2020 who progressed to MF in 2024 and developed AML later that year. Cytogenetic analysis revealed a KMT2A (11q23) rearrangement with KMT2A::ELL fusion, a finding rarely described in secondary AML arising from MPNs. Due to advanced age, transfusion dependence, and significant cardiovascular comorbidities, the …

Spartan Daily, March 17, 2026, San Jose State University, School Of Journalism And Mass Communications

Spartan Daily, 2026

Volume 166, Issue 23

Visdb 20: A Manually Curated Resource Of Viral Integration Sites And Their Regulatory Maps In Human Diseases, Citu Citu, Ajeet Singh, Xinyi Liu, Mounika Ashannagari, Rinki Ratnapriya, Zhongming Zhao

Faculty, Staff and Student Publications

The integration of viral sequence into the human genome plays critical role in the onset of various diseases, especially cancers. To facilitate systematic analysis of these events, we present VISDB 2.0, an expanded and updated database of human viral integration sites (VISs). The current release contains more than 270,000 manually curated VISs derived from 209 peer-reviewed publications, covering 11 viruses, including four retroviruses and seven DNA viruses. This represents a 3.5-fold increase in VIS entries compared with the previous version. Each VIS record includes standardized genomic coordinates and annotations describing local genomic context, CpG islands, repetitive elements, chromosomal fragile sites, …

Is The Long-Horned Grasshopper Ruspolia Differens (Orthoptera: Tettigoniidae) A Novel, Nutritious, Functional, And Safe Alternative Food Product? A Review, Margaret Kababu, Collins Mweresa, Dorothy Nakimbugwe, Geoffrey Ssepuuya, Karlmax Rutaro, Nicodemus Matojo, Faith Nyamu, Robert Mbeche, Sevgan Subramanian, Sunday Ekesi, Chrysantus Tanga

All Peer-Reviewed Publications

Ruspolia differens Serville (Orthoptera: Tettigoniidae) is among the most widely consumed edible insect in Eastern and Central Africa, where it contributes to both household nutrition and income generation. As a nutrient-dense food source, it offers a promising alternative to curb food insecurity and malnutrition. Despite this, the consumption and use of the grasshopper is limited to its seasonal availability when it is collected from the wild. Coupled with this, is limited evidence on its domestication despite research advances to optimize conditions for mass production. This review was conducted to highlight research advances and gaps on production, processing, nutritional profile, and …

“Blue Rings” In Engelmann Spruce From The Greater Yellowstone Ecoregion: Their Presentation And Efficacy As Proxies For Ephemeral Cooling Events, Isaac Grimm, Maegen Rochner

The Cardinal Edge

As the polar jet stream’s activity transforms under climate change’s influence, short-term, or ephemeral, cooling events could become more frequent. Understanding how such cooling events may affect forest dynamics and tree-growth can allow us to predict how the morphing jet stream may reflect in our future forests. “Blue rings” (BRs) have presented themselves as subsections of annual rings, made clear through the double-staining of microsections of wood, which have been associated with the interruption of conifers’ lignification process. Such features could allow us to peer back into pre-instrumental records and assess how a tree’s growth and their surrounding canopy may …

Evolving Solutions For Red Blood Cell Preservation, Ali Alkafaji, Charles A. Elder, Mohammad Zaidi, Kavin Parthiv, Michael A. Menze

The Cardinal Edge

In emergencies such as natural disasters, armed conflicts, or during outer space missions, the availability of transfusable blood can mean the difference between life and death. Red blood cells (RBCs) must be stored at +4 ± 2 °C and have a shelf life of just 42 days, which makes maintaining a stable blood supply during adverse conditions extraordinarily challenging. This challenge was especially apparent during the COVID-19 pandemic when hospitals faced severe blood shortages. Freeze-drying, or lyophilization, offers a promising avenue to extend the shelf life of RBCs for transfusion during crises. However, a significant hurdle in dry preservation is …

Activation Of Autophagy In Human Neutrophils In Response To Emerging Oral Pathogen Peptoanaerobacter Stomatis, Mya Philipose, Shikha Srivastava, Silvia Uriarte

The Cardinal Edge

Background: Periodontitis is a chronic, inflammatory disease that affects over 50% of the global population and is a leading cause of tooth loss. It is associated with the accumulation of oral pathogens that thrive in inflamed environments and contribute to the destruction of gum tissue and underlying bone. Neutrophils, the most abundant immune cells in the oral cavity, serve as the first line of defense against these pathogens. However, some bacteria can alter neutrophil responses to promote their survival, leading to sustained inflammation and tissue damage. This study focuses on Peptoanaerobacter stomatis, a Gram-positive anaerobic bacterium that is highly …

Egf Enhances Re-Epithelization In Our Ex-Vivo Pig Eye Model, Andrew D. Le, Lisandra Plana-Ramos, Kate Tarvestad, Brian Ceresa

The Cardinal Edge

The cornea, the foremost anterior portion of the eye, plays a critical role in vision by refracting light and serving as a protective barrier. Its three distinct layers—the outermost epithelial layer, the thick stromal layer, and the innermost endothelial layer work together to maintain corneal transparency and function. The epithelial layer is particularly susceptible to damage, which can compromise the eye’s defense against foreign particles such as bacteria and viruses, potentially leading to infection and blindness. In this study, we established an ex vivo porcine corneal model to quantitatively and qualitatively investigate corneal re-epithelialization. Using adult pig eyes sourced from …

Effects Of Phosphorus Addition On Fungal Colonization In Little Bluestem, Isabel M. Zanartu, Alexx Nicholas, Mckenzie Goodwyn, Connor Morozumi

The Cardinal Edge

Little Bluestem (Schizachyrium scoparium) is a North American perennial grass that is able to tolerate high heat and droughts. This is possible by its extensive underground root network that taps deep into the ground for resources. Within the same soil systems are fungal endophytes, which are symbionts that live within plant tissues including roots. Fungal endophytes can affect host growth and nutrient acquisition, but the functional role these endophytes play in plant health may be dependent on the abiotic conditions the plant is facing. In the modern era, one large driver of abiotic conditions is synthetic fertilizer use which alters …

Impact Of Legacy Amf Communities On Vegetative Growth & Yield Of Soybean, Dylan Habeeb, Connor Morozumi, Natalie Christian

The Cardinal Edge

Soil microbial communities are increasingly recognized as an important factor in sustainable agriculture. Arbuscular mycorrhizal fungi (AMF), are key players in these communities, known to benefit their plant host in a number of ways, such as increased nutrient uptake. Plants can partner with multiple AMF species; however, little is known about how interactions between multispecies communities of AMF impact plant growth and yield. In an agricultural setting, the long-term development of these communities following practices such as rotational planting or cover cropping is also an important consideration, but there is little research on the long-term legacy of AMF communities or …

Effects Of Salinity On Interactions Between Epichloë Amarillans And Fusarium Spp. In American Beachgrass, Emma G. Mills, Dylan Habeeb, Natalie Christian, Connor Morozumi

The Cardinal Edge

Effects of Salinity on interactions between Epichloë amarillans and Fusarium spp. In American Beachgrass

Emma Mills, Dylan Habeeb, Natalie Christian, Connor Morozumi

Epichloë is a well-known genus of vertically transmitted fungal endophytes in many species of grasses. In Ammophila breviligulata (American beachgrass), Epichloë amarillans is a key endophyte species known to cause chemical and morphological changes to its host and provide protection from stressors. Additionally, Epichloë is thought to influence fungal endophyte community composition within its host. However, deepening research on the interaction of Epichloë with coexisting fungal endophytes may shed further light on its role in community composition. Additionally, …

Urban Areas Are Associated With Earlier Breeding Timing In American Robins, Lola Hackle, Jennifer Wickes, Elise Mittlestat, Ashley Stine, Keegan Abeson, Carolina Villalona, Mikus Abolins-Abols

The Cardinal Edge

Climate change and urban environment have been shown to affect bird reproductive timing. In particular, urban development can create the so-called “heat islands” – urban areas that are hotter than the surrounding environment. While the primary cue birds use to time their reproduction is daylength, birds also use temperature as a supplementary cue to fine-tune their reproductive timing. Change in the timing of breeding may impact the survivability of nestlings due to temperature fluctuations and food availability. The American Robin (Turdus migratorius) is a widespread songbird in North American cities and rural areas. We sought to see if urban heating …

The Effect Of Prenatal Cigarette Smoke Exposure And Adult High-Fat/High-Fructose Diet On Liver Triglyceride Levels, Toni A. Adedokun, Isaiah Burciaga, Megan Jacobs, Katelyn Chism, Anna-Lee Harris, Kristen Overton, Selma Podbicanin, Andrew Potts, Rachel Neal, Cynthia Corbitt

The Cardinal Edge

Prenatal cigarette smoke exposure (CSE) is associated with chronic metabolic disease in adulthood, including obesity, type 2 diabetes, and metabolic dysfunction-associated fatty liver disease. Maternal cigarette smoking reduces uterine and placental blood flow, limiting nutrients and oxygen supply to the fetus. According to the Developmental Origins of Health and Disease hypothesis, these conditions may cause developmental adaptations that are maladaptive in calorie-rich environments. We hypothesized that gestational CSE would sensitize affected offspring to the effects of an adulthood high-fat (40 kcal%), high fructose (20 kcal%) diet. C57BL/6J mice were exposed either to filtered room air (sham) or the smoke generated …

Hallucinogens For Mood And Anxiety Disorders: A Critical Review Of Psychedelic-Assisted Therapies, Georgia Chlebek

The Cardinal Edge

In quite a few people worldwide, there are several mental disorders that prevent the brain from operating in the “proper” way, depression, anxiety, and post-traumatic stress disorder (PTSD) being among the most common. Luckily, there are several medications that are produced and used to treat these disorders, but some medications are hard to access, and others simply don’t help the patient. Firstly, these medications take time to study and prove safe for public use, though in some cases time is not readily available. In other cases, these medications are going through shortages and becoming increasingly difficult for patients to access …

Leaf Droppage Delayed In Sugar Maple Trees On An Urban To Rural Gradient, Isabella S. Bastien, Isabella Bastien

The Cardinal Edge

This study investigates the timing of leaf abscission in Sugar Maple (Acer saccharum) trees along an urban-to-rural gradient in Louisville, Kentucky, to determine how proximity to urban environments influences leaf drop. We hypothesized that urban trees would retain their leaves longer than suburban or rural trees due to environmental stressors and tested this using weekly leaf collection and canopy cover measurements from three locations—urban, suburban, and rural. Results showed that urban trees exhibited delayed leaf drop and slower canopy opening compared to suburban and rural trees. These findings suggest that urban stressors significantly alter tree phenology, which may signal underlying …

Disrupted Nuclear Function And Nucleocytoplasmic Transport In Parkinson’S Disease, Ichiro M. Matoba

The Cardinal Edge

No abstract provided.

Asimina Triloba (L.) Dunal: The Complete Story Of America’S Forgotten Fruit, Autumn M. Howard

The Cardinal Edge

Asimina triloba, commonly known as the pawpaw, is a unique and historically significant native fruit tree of the eastern United States. This research paper explores the taxonomy, botanical description, distribution, habitat requirements, ecological interactions, economic importance, and reproductive biology of A. triloba. The species is distinguished by its tropical-flavored fruits, adaptation to temperate climates, and reliance on clonal reproduction and specific insect pollinators. While offering promising opportunities for sustainable agriculture and riparian restoration, A. triloba faces challenges related to limited seed dispersal, susceptibility to certain pests and diseases, and the presence of neurotoxic compounds. Despite its historical importance …

Development And Preliminary Pressure Control Validation Of Woundwatch: Npwt System With Remote Monitoring Capabilities, Swetha Senthil Nathan

The Cardinal Edge

Chronic wounds, including diabetic foot ulcers, pressure sores, and venous leg ulcers, affect over 40 million individuals worldwide and are often complicated by delayed healing due to limited access to continuous monitoring. Negative Pressure Wound Therapy (NPWT) is an established treatment that promotes wound healing through controlled sub-atmospheric pressure. However, conventional NPWT systems lack real-time physiological feedback and require frequent in-person follow-ups, limiting their effectiveness in remote or low-resource settings. This study presents WoundWatch, a portable, low-cost NPWT device that integrates real-time temperature, humidity, and pressure sensing with wireless data transmission via an IoT platform. The system includes a vacuum …

Lamin A/C And Linc Complex Expression Affects Nuclei's Mechanical Properties And Functions In Osteosarcoma, Shridha Rajeswar

The Cardinal Edge

The nucleus has long been simplified in the field of biology, despite being an important organelle. Until recently, it has been commonly depicted as a simple sphere located at the center of a cell, responsible mainly for regulating protein synthesis. However, current research indicates that the linkers of the nucleoskeleton and cytoskeleton (LINC) complexes, the pillars of nuclear architecture, play a critical role in maintaining nuclear integrity and function. These complexes interact with proteins, such as Lamins, that modulate responses to biomechanical stimuli through the regulation of gene expression. As such, when these structures are downregulated, they can contribute to …

The Silent Epidemic: How E-Cigarettes And Policy Gaps Endanger Public Health, Fizzah Syed, Saumya Sikhwal, Priya Viswakumar

The Cardinal Edge

No abstract provided.

Targeting Glioblastoma: Mechanistic And Clinical Perspectives From Uofl Research, Swetha Senthil Nathan

The Cardinal Edge

Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain tumors, with median survival lingering at 12–15 months despite surgery, radiation, and chemotherapy. This article explores cutting-edge research and clinical efforts at the University of Louisville aimed at improving GBM treatment outcomes. Dr. Joseph Chen investigates the tumor microenvironment, revealing how physical properties such as stiffness and porosity drive GBM cell proliferation, migration, and resistance to apoptosis. His lab’s findings suggest that porosity, rather than stiffness alone, may be a more accurate predictor of tumor invasion and progression-free survival. Additionally, his research highlights the role of hyaluronic acid and …

Sound, Speech, And Synapses: Rebuilding The Brain Through Neuroplasticity, Sireen Khader

The Cardinal Edge

No abstract provided.

What Is The Value Of A State? Accounting For The Ecosystem Service And Natural Capital Values Of Oregon, Kathryn T. Liebrecht, Sahan Dissanayake, Luis Ruedas

Urban Ecosystem Research Consortium of Portland/Vancouver

Ecosystem services are vital to human welfare, but often overlooked in planning and policy. By neglecting to incorporate the benefits received from natural resources, policy makers may unknowingly make decisions that harm the long-term sustainability and use of these services. We used the Institute for Natural Resources’ Oregon statewide habitat map and the Ecosystem Services Valuation Database (ESVD), and value transfer methodology to calculate a range of ecosystem service values for each Oregon ecosystem and its services. We provide an estimate of the total value of Oregon’s natural capital, by county and by ecosystem. We find a total median value …

U.S. Arctic Sea Lines Of Communication (Sloc): The Imperative For A Maritime Complex And Corridor In The Bering Region, Samuel A. Krakower, Troy J. Bouffard

Joint Force Quarterly

This paper examines the current American capacity to defend its newfound Sea Lines of Communication in the North Pacific and Arctic Oceans. The history, and importance, of Sea Lines of Communication trace back to great naval strategists such as Rear Admiral Alfred Thayer Mahan and Sir Julian Corbett, and consistent protection of these maritime corridors in times of war and peace led to the success of the United States. As the Arctic Region emerges as a new theater of geopolitical importance, the United States finds itself significantly disadvantaged or "strategically handicapped” in terms of presence, capability, and proximity to defend …

Editors - Mend V.4, Project Mend

Mend

No abstract provided.

Thermal Imaging Drones: A "Cool" Solution To Incorporating Climate Resiliency In Restoration Design, Amy D. Van Riessen

Urban Ecosystem Research Consortium of Portland/Vancouver

Coldwater fish species, such as salmonids, are highly sensitive to elevated summer water temperatures. However, they can persist in thermally stressful environments by seeking out cold-water refugia (CWR). CWR can include areas where groundwater seeps and springs introduce cooler water into the stream system. These microhabitats are critical for survival during peak temperature periods.

To enhance climate resiliency in restoration planning, the North Clackamas Watersheds Council has integrated thermal imaging drone technology to identify cold-water inputs within project areas. By pinpointing these thermal anomalies, restoration designs can strategically incorporate features such as pools and large wood structures near seeps and …

Handwritten Histories: Exploring Identity Through Personal Correspondence, Savana Hauck

Scholarly Horizons: University of Minnesota, Morris Undergraduate Journal

This project examines handwritten correspondence as a site of gendered and sexual self-discovery, intimacy, and historical continuity. Developed for HIST 2708W - Gender, Women, and Sexuality in Modern Europe - , it centers on a collection of contemporary “snail mail” letters written in response to reflective prompts about participants’ lived experiences of gender and sexuality. These personal narratives are presented in a physical, scrapbook-style format that emphasizes slowness, care, and trust as methodological and ethical practices.

By placing these contemporary letters in dialogue with historical examples of correspondence—including an 1882 letter sent to German psychiatrist Richard von Krafft-Ebing, the intimate …

The Creation And Performance Of Eulogy, Evan Anderson

Scholarly Horizons: University of Minnesota, Morris Undergraduate Journal

In completion of my senior project for my theatre arts degree at the University of Minnesota Morris, I wrote, composed, and directed Eulogy, performing with myself as Mark, Olivia Emmrich as Amelia, Savana Hauck as the Reverend, and Jennie Odello as the pianist. The following will explore my artistic process: highlighting how I chose my topic, my playwriting and composing process, collaborating with my colleagues, our rehearsal process, the performance, and my reflection on my project.

The Vortex–Acoustic Bio‑Refinery (Vabr): A Modular Low‑Pressure System For Converting Sewage Sludge Into Astm‑Compliant Biodiesel, Michael Victor Caldwell Mr.

Defensive Publications Series

The Vortex–Acoustic Bio‑Refinery (VABR) is a conceptual modular system designed to convert municipal sewage sludge into ASTM‑compliant biodiesel using a combination of vortex‑based solids concentration, dual‑frequency acoustic processing, and catalyst‑assisted chemical transformation. The invention proposes a low‑pressure, low‑temperature alternative to high‑pressure hydrothermal liquefaction (HTL), with the goal of reducing mechanical complexity, improving operator safety, and enabling decentralized deployment at wastewater treatment facilities. The VABR concept integrates fluid‑dynamic separation, acoustic disruption of organic structures, and catalyst‑supported biodiesel‑compatible reactions. This disclosure outlines the scientific principles, conceptual system architecture, and potential advantages of the VABR compared to existing waste‑to‑fuel technologies. It is released …

The Marine‑Duo V26‑M System For Organic Mineralized Fertilizer Production From Marine Biomass Waste Streams, Michael Victor Caldwell Mr.

Defensive Publications Series

The Marine‑Duo V26‑M System is an open, modular, and real‑world‑viable process for converting marine biomass waste streams into a stabilized, mineral‑rich organic fertilizer pellet. The system integrates maceration, hydrodynamic cavitation, indirect thermal drying, and controlled pelletization to produce a slow‑release, carbon‑dense fertilizer containing organically bound nitrogen, phosphorus, potassium, and a broad spectrum of marine‑derived micronutrients. The process preserves natural biostimulants such as chitin and alginates, which support soil structure, moisture retention, and plant immune responses. This disclosure provides a complete conceptual blueprint of the system architecture, chemical composition, agronomic benefits, and environmental rationale to ensure the invention remains freely available …