Digital Commons Network^™

S-Equol: A Novel Therapeutic For Hiv-1 Induced Gut Dysbiosis, Mason T. Rodriguez

Theses and Dissertations

HIV-1 infection affects approximately 38 million people around the world. The advent of cART has greatly improved the quality of life of infected individuals; however, roughly 50% of these individuals will still experience HIV-1 associated neurocognitive disorders (HAND). Additionally, the gut microbiome has been reported to be dysbiotic in HIV-1 infected individuals, regardless of adherence to cART. Current research has pointed to the gut-brain-microbiota axis as a potential target to treat both cognitive deficits and microbial changes. The present study investigated S-equol (SE) as a potential therapeutic for HAND by modulating the gut microbiome. The study included 21 HIV-1 Tg …

Physical Frailty And White Matter Abnormalities: The Aric Study, Emma L. Ducca

Theses and Dissertations

Physical frailty is associated with increased risk for dementia and other neurologic sequelae. However, the neurobiological changes underlying frailty and frailty risk remain unknown. The association of cerebral white matter structure with current and future frailty was examined. Atherosclerosis Risk in Communities Study Neurocognitive Study participants who underwent 3T brain MRI were included. Frailty status was classified according to the Fried criteria. Cerebral white matter integrity was defined using white matter hyperintensity (WMH) volume and microstructure, measured using diffusion tensor imaging fractional anisotropy (FA) and mean diffusivity (MD). Multivariable linear regression was used to relate baseline frailty to white matter …

Relationships Between Handgrip Strength Asymmetry And Multimorbidity In Canadian Adults Aged 40 Years And Older: Results From The Canadian Health Measures Survey, Morgan Ann Flann

Theses and Dissertations

Background: Hand-grip strength (HGS) is a convenient, valid, and reliable measure of overall muscle strength that is significantly related to current and future health. HGS asymmetry is an additional aspect of muscle function that can also be measured using handheld dynamometry. The aim of this study was to examine associations between HGS asymmetry and multimorbidity in a nationally representative sample of Canadian adults aged 40 years or older. Methods: A secondary analysis of cross-sectional data was performed on adults aged 40-79 years from six cycles (2007- 2017) of the Canadian Health Measures Survey (CHMS). HGS was assessed using handheld dynamometry, …

Associations Between Handgrip Strength Asymmetry And Health Related Quality Of Life Among Canadian Adults: An Analysis Of The Canadian Health Measures Survey, Jessica Lembke

Theses and Dissertations

Background: Health related quality of life (HRQOL), a measure of perceived quality of health is significantly related to current and future health. Handgrip strength (HGS) asymmetry is an aspect of muscle function that can be measured using handheld dynamometry. While several studies have examined relationships between HGS asymmetry and HRQOL, few have used nationally-representative data, and none have used Canadian data. The aim of this study, therefore, was to examine the association between HGS asymmetry and HRQOL in a nationally-representative sample of Canadian adults.

Methods: A secondary analysis of cross-sectional data from cycles 5 and 6 (2016–17 and 2018–19) of …

Systematic Review Regarding The Use Of Mindfulness-Based Mobile Applications To Reduce Psychological Symptoms And Enhance Well-Being Among General And Clinical Population Adults: Benefits, Limitations And Future Directions, Brian Clawson

Theses and Dissertations

Mindfulness is now utilized throughout Western Society and is part of the growing behavioral health, self-help, and wellness movements. Mobile applications have become increasingly popular for a wide variety of uses related to physical health, mental health, and self-improvement. Therefore, mindfulness-based mobile applications have promise both as stand-alone tools for end-users seeking self-help resources and as clinician-recommended adjunctive tools to enhance the process and outcomes of professional therapy. This systematic review identified, reviewed, and synthesized the findings from studies (n = 29) concerning the impact of mindfulness-based mobile applications on specific aspects of psychological functioning in both the general population …

An Analysis Of The Special Focus Facility Program And Nursing Home Quality, Annie S. Rhodes

Theses and Dissertations

The Special Focus Facility Program is an intensive program meant to rapidly support 88 of the lowest quality nursing homes in the United States, as determined by the Five-Star Quality Ranking system. There are also 435 facility candidates which are similarly low performing but not enrolled in the program. Academic literature has largely ignored this program, and the existing grey literature is more than a decade old and does not include COVID-19 data. Applying a political economy of aging framework and using a case matching methodology, Special Focus Facilities (SFF), Special Focus Facility Candidate (SFFc) nursing homes, and 5-star nursing …

Bonded Or Broken? An Expansion Of Goodman And Gotlib’S Depressive Symptom Transmission Model Extended To Foster Parents And Grandparent Caregivers, Acacia Lopez

Theses and Dissertations

Current literature establishes a relationship between maternal depression and offspring depression. Goodman and Gotlib’s “Developmental Model for Understanding Mechanisms of Transmission” suggests possible mechanisms including attachment. Prior research also demonstrates a link between fathers’ depression and pediatric psychopathology risk, but further research is needed to elucidate the effect of other non-parental caregivers. Children raised by both types of non-parental caregivers are vulnerable to attachment disruptions due to separation from their parental caregivers and the prevalence of children residing with these caregivers is on the rise in recent years. Using the Goodman and Gotlib framework, this study examined the relation between …

Best Friends Forever And Family Ties: Continuity And Change In Closeness With Parents And Friends Among Australian Adolescents, Mckell A. Jorgensen-Wells

Theses and Dissertations

During adolescence, the need for social connection increases. Yet, fostering emotional closeness in relationships becomes more complex, as the need for autonomy also increases and social environments must adapt to become conducive to these seemingly competing needs. This complexity necessitates more research on what happens to close relationships during adolescence, so parents, scholars, and practitioners are better equipped to help individuals navigate the unique social atmosphere of adolescence. The current study draws upon multi-level modeling techniques to estimate growth models of Australian adolescents' closeness to parents and closeness to friends from ages 12-17 and examine predictors of these trajectories. Findings …

Family Structure Variables As Proxies For Socialization And Their Effect On Cognitive Decline: An Empirical Analysis, Peter Amato

Theses and Dissertations

The risk of several common diseases causing dramatic cognitive decline (Alzheimer’s, dementia, anterograde memory loss) and short-term memory impairment are all common, even inevitable ailments as one continues to age. There is a body of literature that suggests stronger social networks reduce the chance of cognitive decline through mentally stimulating activities or socializing. This study examines the rates of cognitive decline in people with larger families by using ordinary least squares (OLS) regression and a cox hazard proportion hazards model to examine the protective effects of different family structures on the rates of cognitive decline using the American Community Supplement …

The Effects Of Sildenafil On Portal Vein Velocity, Cross-Sectional Area, And Congestion Index In The Dog, Christopher Tollefson

Theses and Dissertations

The main use of sildenafil in human medicine is to treat erectile dysfunction. In veterinary medicine, sildenafil is most frequently used to treat pulmonary hypertension. The effects of sildenafil on the portal vasculature in the dog have not been previously evaluated. The purpose of this study was to evaluate the effects sildenafil has on the portal vasculature. The cross-sectional area of the aorta, cross-sectional area of the portal vein, and portal vein velocity were acquired in thirteen dogs prior to administration, 45 minutes, 90 minutes, and 120 minutes after the oral administration of sildenafil for the treatment of pulmonary hypertension. …

A Comparison Of Heat Treatment-Induced Skeletal Muscle Adaptations Relative To Exercise Training, Jamie Puanani Brun Kaluhiokalani

Theses and Dissertations

In vitro and animal studies indicate that the response to heat stress is associated with beneficial adaptations that promote cell health and survival. Few studies to date have examined this finding in human subjects, and it is unclear how the adaptation compares in magnitude to exercise training. The purpose of this study was to investigate the skeletal muscle adaptations (namely mitochondrial biogenesis and capillarization) of 6 weeks of deep-muscle heat treatment relative to exercise training. We hypothesized that heat treatment (HT), applied through pulsed shortwave diathermy (2 hr, 3 days/week) over a 6-week intervention period would lead to increased mitochondrial …

Distinct Spatiotemporal Regulation Of The Cytoprotective Heat Shock Response In Caenorhabditis Elegans, Rosemary Nadine Plagens

Theses and Dissertations

Every organism studied to-date utilizes the heat shock response (HSR) to maintain protein-folding homeostasis (proteostasis) during temperature or other protein-folding stress. The HSR has been well characterized using acute heat stress (HS) in single-celled models, but less is known about how distinct cell types and tissues respond to HS. Furthermore, how metazoans respond to prolonged HS at the molecular level remains relatively unexplored. The model organism C. elegans, with its genetic tractability and distinct tissues and behaviors, has been used extensively in the field to characterize the acute HSR, but with considerable variability across labs regarding HS temperature and duration. …

Lexical Properties Of Perceptual Errors Made By Younger And Older Adults Listening To Speech In Multitalker Babble, Hannah Blythe Vickery

Theses and Dissertations

Purpose: The purpose of this error analysis was to analyze the lexical properties of misperceptions made when listening to speech in multitalker babble.

Methods: Twenty young adults with normal hearing (YNH), 20 older adults with normal hearing (ONH), and 22 older adults with hearing impairment (OHI) completed a speech-in-babble task. Participants were asked to repeat the final word in 25 high and 25 low context sentences. On each trial, participants either responded with the correct target word, a misperception error, or skipped the trial response. Misperceptions were compiled and analyzed according to their lexical properties.

Results: Results of this study …

Examining The Mental Health Of Older Hispanic/Latino Adults: Relationship Between Psycho-Social-Cultural Factors And Depressive Symptomatology, Anna Prado

Theses and Dissertations

The most prevalent disorders affecting the older adult population worldwide are dementia and depression. Ethnic minorities are disproportionately more likely to be affected by these two distressing and debilitating conditions. Hispanic/Latino older adults encounter numerous psycho-social-cultural factors that influence health behaviors, attitudes, and beliefs in positive and negative ways. Presently, research on the influence of these factors on Hispanic/Latino mental health is highly inconsistent. The purpose of the present study is to examine the relationship between selected psycho-social-cultural factors and the mental health of older Hispanic/Latino adults. Using data from the Health and Retirement Study, the association between the Hispanic/Latino …

Depresioni Tek Të Rriturit, Shkaqet Dhe Roli I Infermieres, Evlijana Alidema

Theses and Dissertations

Hyrja: Depresioni përkufizohet si gjendje e shëndetit mendor që karakterizohet nga katër ose më shumë simptome, si ndryshimet në disponim, oreks, gjumë, anhedoni, letargji, ndjenja e fajit dhe vetëbesimit të ulët, vështirësi në përqëndrim, agjitacion dhe ide për vetëvrasje. Në mesin e çrregullimeve psikiatrike depresioni është një sëmundje me një frekuencë të lartë në mbarë botën dhe paramendohet të jetë shkaku i dytë i sëmundshmërisë në dekadat e ardhshme.

Qëllimi i punimit: Qëllimi i punimit ishte identifikimi i shkaktarëve të depresionit tek të moshuarit dhe roli i infermierëve gjatë punës me personat me depresion.

Materiali dhe metodologjia: Metodologjia e këtij …

Vetë – Kujdesi I Pacientëve Me Sëmundje Kronike Të Dështimit Të Zemrës Në Komunën E Prizrenit, Zani Arapi

Theses and Dissertations

Kujdesi për veten; janë aktivitete të cilat i realizon individi me qëllim të përmirësimit të jetës, shëndetit dhe mirëqenies së tij. Kujdesi për veten; përfshin mirëmbajtjen e kujdesit për veten dhe menaxhimin e vetë-kujdesit. Kujdesi për veten; zhvillohet me kalimin e kohës përmes komunikimit, kulturës dhe ndërveprimit. Ndërsa vetë fuqia e mirëmbajtjes; është aftësia e një individi për t`i kryer aktivitetet e përcaktuara. Tek pacientët me dështim të zemrës kujdesi për veten do të thotë kufizimin ose lënien e pirjes së duhanit, alkoolit, kufizim të marrjes së lëngjeve, pajtueshmëri me ilaçet, dietë, ushqim i përgaditur me pak kripë, vazhdimit ushtrime …

"I Understand, Honey": Perceived Spousal Empathy's Moderating Influence On The Links Between Depression And Marital Satisfaction And Marital Satisfaction And Physical Health, F. Javier Celestino

Theses and Dissertations

An adapted version of the Vulnerability-Stress-Adaptation model was used as a theoretical guide for this study, which proposes that adaptive processes exist and can moderate relationships between enduring vulnerabilities and different outcomes. Relationships of interest include the negative link between depression and marital satisfaction and the positive link between marital satisfaction and physical health. An adaptive process of interest is empathy, due to its well-researched positive impact on mental, relational, and physical health. This study examined whether perceived spousal empathy (i.e., the empathy perceived by one spouse coming from their spouse) had any moderating effects on the previously mentioned links. …

The Relationship Between Hip Mobility And Performance On The Functional Movement Screen In Apparently Healthy Older Adults: A Preliminary Study, Kimberly Jaye Lindstrom

Theses and Dissertations

Limited or asymmetrical hip mobility can affect movement patterns common to everyday living. The aim of this study was to evaluate the relationship between hip mobility and performance on the Functional Movement Screen (FMS) in apparently healthy older adults. This relationship was evaluated in both males and females. In this observational study, 20 older adults (10 male, 10 female, mean age = 65.65 ± 10.18 years old) completed the Functional Movement Screen and measurements of passive hip range of motion. Separate regression analyses and Pearson Product-Moment Correlations were used to evaluate the relationship between hip mobility measures and FMS composite …

The Effect Of Dietary Fiber On Epigenetic Regulation Of Gene Expression In Hemodialysis Patients, Isabelle Strack

Theses and Dissertations

Objective: More than 2/3 of those with kidney failure use hemodialysis as a treatment option. The purpose of this pilot study is to increase the understanding of the epigenetic changes that occur in hemodialysis patients through dietary fiber intake. Design and Methods: Gene expression through epigenetic changes of dietary fiber intake and soluble fiber intake were analyzed in this cross-sectional study. Data was collected from questionnaires and blood samples (n=20). Block Dialysis Food Frequency Questionnaire was used to calculate dietary fiber intake. Blood analysis counted the top 100 most prevalent microRNAs (miRNA). Pearson r correlation was used to determine level …

Autophagic Reprogramming Of Bone Marrow-Derived Macrophages, Mayada Mahmoud Zaki Mohamed Mazher

Theses and Dissertations

ABSTRACT Background: Macroautophagy is a highly conserved catabolic process among eukaryotes. Autophagosome is a piece of double-membrane machinery that fuses with lysosomes during macroautophagy to form autolysosomes. Autolysosome degrades organelles and organizes the pathogen engulfment during phagocytosis in innate immunity. Macrophages are highly dynamic immune cells that orchestrate the host-pathogen interaction. Interestingly, autophagy is implicated in disease pathophysiologies such as Crohn’s disease, cancer, and neurodegenerative diseases. Therefore, we studied the interplay between autophagy and macrophage polarization (activation) through two approaches: 1- Systems biology approach to construct the genetic regulatory network and pathway analysis. And to predict the target proteins that …

An Analysis Of Education As A Moderator Of The Relationship Of Discrimination To Depression, Jeavonna M. Coble

Theses and Dissertations

Racism has been observed as a highly prevalent psychosocial stressor across minorities, and consistently associated with depression across racial/ethnic groups. However, existing evidence is unclear on effective buffers of discrimination to depression. Researchers have hypothesized that education may mitigate discrimination’s effects on negative mental health outcomes. Evidence evaluating education as a buffer on the relations of discrimination to depression is limited. The analysis is further complicated as the evidence linking education level to discrimination exposure is also mixed. Although some studies indicate lower education levels are associated with greater perceived racism, many studies indicate an association of higher education with …

Using The Memorial Sloan Kettering Frailty Index To Identify Patients At High Risk For Postoperative Intensive Care Unit Admission, Specialized Advanced Care Unit Admission, And 30-Day Readmission, Timothy J. Donoghue

Theses and Dissertations

Frailty is roughly defined as an accumulation of physiological, emotional, cognitive, and social deficits that impair a person’s response to stressful events. A frailty diagnosis has been associated with poor outcomes following surgical procedures. Cancer surgical patients aged 65 or older represent a vulnerable population susceptible to being frail and the potential associated complications that can accompany frailty. Measuring frailty is an objective risk assessment that identifies increased risk better than age or American Society of Anesthesiologists Physical Status (ASA-PS) score such that frailty can independently predict poor surgical outcomes.

Frailty is not specifically a result of having cancer, disability, …

Psychological Sense Of Community Among Older Adults In Puerto Rico Two Years After Hurricane María, Thomas D. Buckley

Theses and Dissertations

Hurricane María devastated Puerto Rico in 2017 and resulted in adverse long-term outcomes. Psychological sense of community (PSOC) may serve as a protective factor against the effects of Hurricane María for older adults in Puerto Rico. Using a three-paper format, this dissertation draws on a resilience framework and theories of PSOC and the Ecological Theory of Aging to examine the role of PSOC among older adults in Puerto Rico two years after Hurricane María.

Paper one is a scoping review of the concept of PSOC in research with community dwelling older adults. I begin by presenting findings on study characteristics …

The Relationship Between Digit Ratio (2d:4d) And Muscular Fitness: A Systematic Review And Meta-Analysis, Brooke Pasanen

Theses and Dissertations

Background: Digit ratio (2D:4D), a marker of prenatal testosterone exposure, is a weak negative correlate of sports/athletic/fitness performance. While numerous studies have examined the relationship between 2D:4D and physical fitness, there has never been a comprehensive study that has synthesized studies examining relationships between 2D:4D and muscular fitness. Objectives: To systematically review and meta-analyze the relationship between 2D:4D and muscular fitness measured as handgrip strength (HGS). Methods: This study systematically searched five electronic databases, reference lists, topical systematic reviews/meta-analyses, and personal libraries in November 2020. Peer-reviewed, cross-sectional studies that reported Pearson’s correlation coefficients between objectively measured 2D:4D and HGS were …

The Institute For Storytelling & Healthcare Design Research, Ruth E.P. Deibler

Theses and Dissertations

STORYTELLING, HEALTHCARE, INTERIOR DESIGN EDUCATION & GROUNDED THEORY RESEARCH:

THE TRIFECTA OF TRANSFORMATIONAL CHANGE IN HEALTHCARE DESIGN

Rheological Analysis Of The Mechanical Properties Of Murine Lungs Over The Lifespan, Olajumoke Olufunke Harrison

Theses and Dissertations

To study the effects of aging in murine lungs, we characterized C57Bl6j mice from neonatal to 24-month-old mice. Samples were divided into two groups: Young Mice (YM) and Middle Age/Old Age Mice (MOM). The YM group included the neonatal and 6-10week. The MOM group included 7- and 22–24-month-old mice. Rheological testing was performed using a TA Instruments DHR-2 Rheometer to collect the mechanics of each mice sample. Utilizing a 20-mm parallel plate fixture, a gap of 0.8-1.0-mm, and a temperature setting of 25C, we conducted a frequency sweep. Samples were the decellularized over a four-day process then lyophilized for mass …

Socio-Ecological Predictors Of Social Connection Among Older Adults, Georganna Amateau

Theses and Dissertations

Decades of research has established an unequivocal link between states of social connection and health status. Lack of social connection, whether construed as social isolation or loneliness, negatively influences health and is highly associated with cardiovascular disease, high blood pressure, fall risk, and premature death. Despite extensive research on social isolation and loneliness, evidence relative to the broader construct of social connection suffers. Few studies inform practice standards for community-based organizations. This study aimed to develop a multidimensional, continuous composite variable of social connection and use the composite variable to examine predictors with a socio-ecological lens.

A secondary data analysis …

Feeling The Squeeze: The Association Between Multigeneration Caregiving And Informal Caregivers’ Health, Christine L. Patterson

Theses and Dissertations

While U.S. public policy and research has focused on the health needs of the aging population, less attention has been given to the consequences informal caregivers face caring for this generation. With the segment of the population aged 65 years or older growing rapidly, it is important to understand the factors that place informal caregivers at risk for poor health outcomes and health behaviors. Since multigeneration caregivers balance more personal, work, and caregiving demands than single-generation informal caregivers of older adults, they may be at higher risk for poor health outcomes. The aim of this study was to examine the …

Feedback And Social Comparison: The Effects Of Comparing One’S Performance To The Group, Ryan Joseph Walz

Theses and Dissertations

Although feedback has been shown to improve performance, few studies have examined the effect of feedback containing information on peer performance. The purpose of this study was to evaluate the effects of feedback on individual performance and feedback containing information on peer performance. Three participants were exposed to a no-feedback baseline condition, a standard individual feedback condition, and an individual feedback condition with information on the group’s average performance. The dependent variable was the rate of correct responses on a computer-based simulated work task. Withdrawal designs were used to evaluate the effect of the two types of feedback on performance. …

The Effects Of Passive Hallux Adduction On Posterior Tibial Artery Blood Flow Compared To The Lateral Plantar Artery, Jaysen Alani Hatch

Theses and Dissertations

Passive hallux adduction has been shown to decrease blood flow in the lateral plantar artery (LPA) in a non-weight-bearing condition. Further research in weight-bearing and shod conditions is necessary to explore relationships between altered blood flow and injury or tissue healing. However, measuring blood flow in a shod foot would require an alternate measurement location to accommodate footwear, such as the more proximal posterior tibial artery (PTA). PURPOSE: To determine changes in blood flow in the PTA and LPA subsequent to passive hallux adduction and to compare the observed changes between the two arteries. Second, to determine if measurement at …