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Time Spent Jogging/Running And Biological Aging In 4,458 U.S. Adults: An Nhanes Investigation, Christina Michelle Blackmon Apr 2024

Time Spent Jogging/Running And Biological Aging In 4,458 U.S. Adults: An Nhanes Investigation, Christina Michelle Blackmon

Theses and Dissertations

Telomere length is a good index of cellular aging. Longer telomeres are predictive of longer life, and healthy lifestyles are associated with longer telomeres. This study explored the relationship between time spent jogging or running each week and leukocyte telomere length (LTL) in 4,458 randomly selected U.S. adults. The association was studied using data collected by the National Health and Nutrition Examination Survey (NHANES), and a cross-sectional design. Total weekly jog/run time was calculated from survey responses. From the minute totals, three categories were formed: <10 minutes/week, 10-74 minutes/week, and ≥75 minutes/week. Adults in the third category met the U.S. guidelines. Data were analyzed using one-way ANOVA. Partial correlation was used to adjust for differences in potential mediating factors, including demographic and lifestyle/medical factors. In the total sample, after adjusting for all the potential covariates, mean LTL significantly differed across the 3 jog/run categories (F=4.1, P=0.0272). Specifically, adults who met the guidelines via jogging and/or running had significantly longer telomeres than adults who performed no jogging/running. Adults in the middle category did not differ from the other two categories. A minimum of 75 minutes of jogging/running weekly is predictive of longer telomeres when compared to adults who do not jog or run regularly.

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The Effects Of Diesel Exhaust Particle Exposure On Adipos Mitochondrial Bioenergetics And Inflammation, Cali Elizabeth Warren Mar 2024

The Effects Of Diesel Exhaust Particle Exposure On Adipos Mitochondrial Bioenergetics And Inflammation, Cali Elizabeth Warren

Theses and Dissertations

Fine particulate matter (PM2.5) constitutes a significant component of ambient air pollution that has been implicated in the pathogenesis of metabolic disorders, including insulin resistance and type 2 diabetes. Among PM2.5 constituents, diesel exhaust particles (DEP) are prevalent particulates that infiltrate the bloodstream to drive systemic pathologies. The purpose of this study was to characterize the metabolic response of adipose tissue to DEP. We aimed to provide a comprehensive understanding by exploring mitochondrial bioenergetics, characterizing the inflammatory marker profile, including adipokines, and conducting a detailed histological analysis of adipocytes to provide valuable insights to the evolving understanding of the intricate …

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The Intersection Of Family Environment, Personality Development, And Life Satisfaction, Ché Malik Ashé Jan 2024

The Intersection Of Family Environment, Personality Development, And Life Satisfaction, Ché Malik Ashé

Theses and Dissertations

This study explores the interplay between family environment, parental bonding, personality traits, personality dysfunction, and life satisfaction among college undergraduates. Participants were comprised of college undergraduates (N = 736; 79% female) and we obtained measures of big five personality dimensions, parental bonding, family environment, personality dysfunction, and life satisfaction. Findings indicate that emotional stability is the strongest predictor of life satisfaction, while negative affect is strongly correlated with personality dysfunction. Paternal bonding and family environment were particularly influential in shaping personality traits, which in turn impacted life satisfaction. Additionally, personality dysfunction traits show a stronger correlation to parental care than …

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The Effect Of The Gocomm Educational Intervention On Physician Distress Surrounding Goc Conversations Using The Physician Distress Inventory (Pdi), Thomas Anthony Bozzo Jan 2024

The Effect Of The Gocomm Educational Intervention On Physician Distress Surrounding Goc Conversations Using The Physician Distress Inventory (Pdi), Thomas Anthony Bozzo

Theses and Dissertations

End-of-life (EOL) care refers to the medical, emotional, and practical support provided to individuals who are nearing the end of their lives. Goals of care (GOC) discussions involve physician exploration of patient beliefs and values, though they do not need to be primarily focused on end-of-life health-care decisions. Engaging in EOL/GOC conversations has been linked to increased quality of life, decreased healthcare costs, and more frequently receiving care in line with patient preferences. Barriers to these discussions occurring exist at both the clinician-level (e.g., inadequate communications training) and the patient-level (e.g., heightened death anxiety). This study aimed to determine if …

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Fostering A Culture Of Belonging Within Women Working In A Hybrid Environment, Jam Narte Harley Jan 2024

Fostering A Culture Of Belonging Within Women Working In A Hybrid Environment, Jam Narte Harley

Theses and Dissertations

This research discusses the opportunity presented by the post-pandemic return to work to support Diversity, Equity, Inclusion, and Belonging initiatives by creating a new belonging framework for women working in a hybrid environment. The transition to remote and hybrid work arrangements amid the pandemic highlighted the importance of leaders tackling ongoing challenges in leadership and management, such as digital transformation and remote management, which led to rapid change, anxiety, and uncertainty. The lack of daily contact has significantly impacted workplace relationships and highlighted the importance of belongingness for employees' well-being and retention. Hybrid work arrangements are likely to become a …

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Assessing Providers’ Readiness To Integrate Mat Services In A Primary Care Setting, Carmen Ingram-Thorpe Jan 2024

Assessing Providers’ Readiness To Integrate Mat Services In A Primary Care Setting, Carmen Ingram-Thorpe

Theses and Dissertations

Opioid use disorder is a growing concern in the United States. Despite medication-assisted treatment (MAT) being a more effective treatment option than behavioral treatment alone, primary care providers’ rate of adoption and utilization of MAT has not matched the demand of the opioid crisis. The largest barrier facing our local community is the availability of organizations and providers that can and will actually provide MAT services. The purpose of this study was to identify factors that impact primary care providers’ readiness to treat individuals with opioid use disorder (OUD) using MAT. This study used the ADKAR model as framework, which …

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Bridging The Gaps: Characterizing Alzheimer's Disease In Native Hawaiian And Pacific Islander Populations, Justina P. Tavana Dec 2023

Bridging The Gaps: Characterizing Alzheimer's Disease In Native Hawaiian And Pacific Islander Populations, Justina P. Tavana

Theses and Dissertations

This dissertation addresses critical gaps in dementia research in Native Hawaiian and Pacific Islander (NHPI) communities. Focusing on Samoan and Tongan communities, the study successfully adapted and validated the AD8 informant interview and the Clinical Dementia Rating (CDR) scale in native languages, establishing these instruments as reliable tools for detecting cognitive impairment in these populations. The research process prioritized meaningful community engagement and forged partnerships with indigenous professionals, ensuring alignment with and responsiveness to the specific needs of the community. These invaluable connections were the foundation of making this difficult work possible. Subjects assessed with these adapted instruments were enrolled …

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Invisibility, Confusion, And Adjustment:Exploring The Grief Experience Of Grandmothers Supporting Their Bereaved Grandchildren, Jordan Robertson Dec 2023

Invisibility, Confusion, And Adjustment:Exploring The Grief Experience Of Grandmothers Supporting Their Bereaved Grandchildren, Jordan Robertson

Theses and Dissertations

Bereavement is painful at any time of life. For young children experiencing bereavement, grandmothers are often the first line of defense. Grandmothers are frequently called upon when their family members experience an out-of-order death, and while they are willing to provide care, grandmothers don't always know the best way forward. This qualitative study sought to learn more about the grief experiences of 22 grandmothers who had lost a family member prematurely through semi-structured interviews and Interpretive Phenomenological Analysis. Findings suggest (a) grandmothers experience layered grief in that they grieve the loss of the family member, experience the pain of the …

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Adverse Childhood Experiences And Social Determinants Of Health In Relation To Cigarette Smoking And E-Cigarette Use Among Adults, Kankana Sengupta Oct 2023

Adverse Childhood Experiences And Social Determinants Of Health In Relation To Cigarette Smoking And E-Cigarette Use Among Adults, Kankana Sengupta

Theses and Dissertations

Cigarette smoking is the leading cause of preventable morbidity and premature mortality in the U.S. and other high-income nations. E-cigarette use or vaping is an addictive behavior. During the past 5 years, the prevalence of e-cigarette use has increased markedly in U.S. adolescents and young adults. The public health implications of this increased prevalence are unclear. Adverse childhood experiences (ACEs) are associated with cigarette smoking in adulthood. However, the pathway from experiencing ACEs in childhood to smoking cigarettes or using e-cigarettes in adulthood is not clearly understood. Additional factors experienced between childhood and adulthood might either increase or decrease the …

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Investigating The Localization Of Foxo4 Transcription Factor In U87mg Glioblastoma Cell Line, Millat Jahan Aug 2023

Investigating The Localization Of Foxo4 Transcription Factor In U87mg Glioblastoma Cell Line, Millat Jahan

Theses and Dissertations

FOXO transcription factors perform diverse functions that have effects on significant biological processes like stem cell homeostasis, cell cycle, apoptosis, and cell fate determination. This research focuses on FOXO4 that is differentially localized in U87MG glioblastoma cells where FOXO4 is targeted to the nucleus. This research is aimed at investigating the mechanism and localization of FOXO4 in U87MG cell lines. Using chimeric fusion construct, we have mapped regions within FOXO factors that can determine specific cellular localization patterns. Finding the mechanism behind specific nuclear localization of FOXO4 can produce innovative data to better understand the distinctive subcellular localization patterns in …

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The Effect Of Therapeutic Alliance Quality On Relationship Quality, With Latino Ethnicity As A Moderator: An Exploratory Study, Ivana Elisa Borba Gomez Jul 2023

The Effect Of Therapeutic Alliance Quality On Relationship Quality, With Latino Ethnicity As A Moderator: An Exploratory Study, Ivana Elisa Borba Gomez

Theses and Dissertations

A strong therapeutic alliance is consistently related to successful outcomes in couple therapy. However, most of the research done on therapeutic alliance has been done among non-Latino White individuals and couples, failing to account for other ethnic minorities like Latinos. Latinos tend to share certain commonalities as opposed to non-Latino clients that may alter the relationship between alliance quality and relationship quality. This exploratory study was designed to understand whether Latino clients have higher initial levels of alliance and a stronger alliance-outcome relationship in couple therapy when compared to non-Latino White couples. The sample consisted of 567 couples seeking therapy …

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Predictors Of Driving Performance Post-Stroke, Halle Elise Prine Jul 2023

Predictors Of Driving Performance Post-Stroke, Halle Elise Prine

Theses and Dissertations

Driving is a complex skill involving the interaction of various brain functions, making it challenging to determine the independent contributions of each process to driving proficiency. While past studies have identified assessments such as the Useful Field of View Test (UFOV) and the Trial Making Test (TMT) as strong predictors for driving skills, little research has explored the impact of visual search and movement inhibition on driving after stroke. This cross-sectional study includes participants between the ages of 21 to 80 years with residual disability caused by a unilateral middle cerebral artery stroke at least six months prior. The participants …

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Mental Health Literacy In Polynesian Native Hawaiians And Other Pacific Islanders: A Pilot Cross-Sectional Study, Kealoha Sarah Reiko Snow Jun 2023

Mental Health Literacy In Polynesian Native Hawaiians And Other Pacific Islanders: A Pilot Cross-Sectional Study, Kealoha Sarah Reiko Snow

Theses and Dissertations

Background: High prevalence of mental health problems and underutilization of mental health treatment are more severe among the Native Hawaiian and Other Pacific Islander (NHPI) population and remain misunderstood and understudied. Examining mental health literacy (MHL)–the knowledge and beliefs about mental disorders which aid their recognition, management, or prevention–has been shown to identify barriers to seeking and receiving care. Objectives: This study aimed to assess the level of MHL in Polynesian NHPIs and identify associated demographic variables. Methods: Data for this pilot cross-sectional study were collected from 298 US Polynesians via an online questionnaire of the Mental Health Literacy Scale …

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Assessing The Correlation Between The Socioeconomic Level And Cognitive Function Among Older Adults In Egypt, Macy Abougabal Jun 2023

Assessing The Correlation Between The Socioeconomic Level And Cognitive Function Among Older Adults In Egypt, Macy Abougabal

Theses and Dissertations

The number of older adults is increasing worldwide at an unprecedented rate. Some countries began to understand the challenges of aging, while others are still at the stage of comprehending the true dimensions of the situation. There is a global focus on aging research to appropriately mitigate the negative impact of aging and cognitive decline. Not only that dementia add economic pressure on governments, it also increase the psychological and physical burden of the caregivers. Scholars have previously studied socioeconomic level in three variables, namely work, education, and income, and their relationship with cognitive function. It was concluded that the …

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An Investigation Into Transcription Fidelity And Its Effects On C. Elegans And S. Cerevisiae Health And Longevity, Olivia S. Dinep-Schneider May 2023

An Investigation Into Transcription Fidelity And Its Effects On C. Elegans And S. Cerevisiae Health And Longevity, Olivia S. Dinep-Schneider

Theses and Dissertations

mRNA molecules form an intermediate in the transfer of sequences from DNA to ribosomes in order to guide protein production. Errors can be introduced into mRNA, producing aberrant proteins which place a strain on cellular regulatory machinery, causing increased risks of apoptosis, cancer, and decreased fitness. These errors may be introduced due to decreased transcriptional proofreading capabilities, exposure to chemicals, or mistakes in RNA editing machinery. It is important to investigate these causes of transcription errors to better understand the long-neglected area of mRNA fidelity which has such significant impacts on our cellular functions. In this paper, it was determined …

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Anxiety, Depression, And Fear Of Dependency In Middle And Older Adults, Darby D. Mackenstadt May 2023

Anxiety, Depression, And Fear Of Dependency In Middle And Older Adults, Darby D. Mackenstadt

Theses and Dissertations

Negative stereotypes of aging, such as dependency, tend to paint a picture of older adults as frail or a burden on society. This study aimed to explore the relationship between the Fear of Dependency Scale and anxiety and depression, evaluating gender, age, and physical health as moderators. Findings suggest that age moderated the relationship between fear of dependency and depression and anxiety in women, with middle-aged women reporting the highest levels of depression and anxiety. Similarly, poor physical health in women with high fear of dependency being related to higher levels of depression and anxiety. Fear of dependency was related …

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Gyno-Gerontological Discourse And The Dearth Of Old Women Narrators In British Fiction 1790-1860, Lavender Elisabeth Earnest Mar 2023

Gyno-Gerontological Discourse And The Dearth Of Old Women Narrators In British Fiction 1790-1860, Lavender Elisabeth Earnest

Theses and Dissertations

This thesis explores the remarkable dearth of old woman narrators in British fiction between 1790 and 1860, both documenting their under-representation and explaining it as, in part, a product of a wave of medical discourse disparaging the physical and mental vitality of post-menopausal women. Regarding methodology, I perform a random sample upon a corpus of first-person novels published in the period and categorize each according to the gender and age of the narrator. This analysis exhibits, unsurprisingly, that most narrators in the dataset are either in the first half of their life, male, or both. Old women represent only a …

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The Effects Of The Social Security Amendments Of 1983 On Employment Status, Alcohol Consumption, And Depression, Adam J. Delgenio Jan 2023

The Effects Of The Social Security Amendments Of 1983 On Employment Status, Alcohol Consumption, And Depression, Adam J. Delgenio

Theses and Dissertations

Nearly four decades ago, Congress passed the Social Security Amendments of 1983. The changes were significant, and they pressured people to delay retirement. In this thesis, I use individual-level data from the Annual and Social Economic Supplement of the Current Population Survey and the Health Retirement Study to analyze the effects of the amendments. The amendments affect individuals at the same age, but across different years. Year of birth determines treatment by the amendments. I control for year of birth and age effects in a difference-in-difference model and interact treatment with age to identify the effects of the amendments on …

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The Relationship Of Developmental Stages In Adults In Psychotherapy To Different Types Of Mental Health Symptoms, Shannon E. Gasparro Jan 2023

The Relationship Of Developmental Stages In Adults In Psychotherapy To Different Types Of Mental Health Symptoms, Shannon E. Gasparro

Theses and Dissertations

In this study, we examine the pattern of mental health symptoms across adult development using data from a community-based clinic in Queens, NY. Age was represented by three qualitative stages, “early adulthood,” “middle adulthood,” and “late adulthood.” Early adulthood has been characterized as a period of heightened emotional instability, with less clear long-term commitments to romantic relationships, career paths, work, and living arrangements. Middle adulthood has been characterized as a more emotionally stable period in terms of relations with friends and family and social roles. Finally, late adults, although also viewed as more emotionally regulated, may again experience greater interpersonal …

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Psychological Distress Mediates The Relationship Between Health And Satisfaction With Daily Marital Interactions: A Daily Diary Assessment, Stephanie L. Richardson Dec 2022

Psychological Distress Mediates The Relationship Between Health And Satisfaction With Daily Marital Interactions: A Daily Diary Assessment, Stephanie L. Richardson

Theses and Dissertations

Literature has often connected the variables of physical health, mental health, and romantic relationship satisfaction or quality. However, there has yet been any evidence of a mediating relationship. The purpose of this study is to test for mediation of satisfaction with daily marital interactions on physical symptoms through psychological distress. The data is from the Life and Family Legacies Daily Experiences Study and includes 191 older couples over the course of 14 days. Multilevel dyadic models were estimated for both the same-day data as well as lagged data. Indirect effects between the variables were significant, but not for the lagged …

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African American Family Members’ Needs And Experiences During A Loved One’S End-Of-Life, Kelley Obringer Dec 2022

African American Family Members’ Needs And Experiences During A Loved One’S End-Of-Life, Kelley Obringer

Theses and Dissertations

This study aimed to explore African American family members’ needs and experiences during their loved one’s end-of-life. In Chapter 1, a literature review was conducted to review the current state of the literature regarding African American family members’ needs and experiences during their loved one’s end-of-life. Chapter 2 includes a qualitative exploratory study of African American family members’ needs and experiences during their loved one’s end-of-life. The study sample consisted of family members of African Americans being cared for through services provided by an outpatient palliative care facility in the Southeastern United States. Family members answered five open-ended interview questions …

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Healthcare In A Time Of Crisis: An Investigation Of The Association Between Socioeconomic Status, Counties, And Covid-19, Jorge F. Contreras Dec 2022

Healthcare In A Time Of Crisis: An Investigation Of The Association Between Socioeconomic Status, Counties, And Covid-19, Jorge F. Contreras

Theses and Dissertations

The COVID-19 pandemic has stressed social structural institutions such as hospitals, schools, the economy, and governmental bodies (local, state, and federal), exacerbating existing health inequality. Fundamental Cause Theory (FCT) provides a framework for understanding which factors drive such inequality, but its primary focus is on within-group variation. By highlighting the role of fundamental causes as systems of exposure, the Systems-of-Exposure (SOE) approach expands on FCT to account for variation more directly between populations. I performed a Qualitative Comparative Analysis (QCA) of county-level data from Texas and California to test the utility of SOE in assessing the impact of a pandemic …

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The Regulation Of Oxidative Stress In Age-Related Diseases, Jesica Burkhart Jul 2022

The Regulation Of Oxidative Stress In Age-Related Diseases, Jesica Burkhart

Theses and Dissertations

Oxidative stress and mitochondrial dysfunction have been linked to multiple age-related diseases including common neurodegenerative diseases Alzheimer's disease (AD) and Parkinson’s disease (PD). A gene found to regulated oxidative stress and aging is a stress response gene p38 MAPK (p38K). Oxidative stress arises when the over production of reactive oxygen species (ROS) from within the cell or from environmental stimuli outweighs its clearance by antioxidants. This cascade leads to DNA damage, mitochondrial damage, and cell death. Mitochondrial dysfunction and oxidative stress are markers for biological aging. As we age mitochondrial DNA becomes more sensitive to damages and mutations. When the …

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The Apoe Ε4 Allele Association With Cholesterol Related Phenotypes In The Mexican American Population, Stephanie Lozano Jul 2022

The Apoe Ε4 Allele Association With Cholesterol Related Phenotypes In The Mexican American Population, Stephanie Lozano

Theses and Dissertations

Diseases linked to high cholesterol have been well studied and several diseases-associated candidate genes have been suggested. Among these, the apolipoprotein E gene (APOE) gene associated with lipid metabolism and lipid-related traits was reported in the non-Hispanic population. There are three types of alleles APOE ε2, ε3, and ε4. The APOE ε4 allele has been identified as a biomarker for Alzheimer’s disease (AD) and cardiovascular disease (CVD). In recent years, there have been limited studies regarding the association between the APOE gene and hypercholesterolemia in the Mexican American population. Therefore, the aim of this study is to investigate …

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Socioeconomic Potential: Predicting Income Through The Moderating Effect Of Socioeconomic Status On Social Capital, Virginia K. Leiter Jun 2022

Socioeconomic Potential: Predicting Income Through The Moderating Effect Of Socioeconomic Status On Social Capital, Virginia K. Leiter

Theses and Dissertations

Social capital is an important predictor of socioeconomic attainment, defined here as household income, but it is less clear how this relationship may vary by socioeconomic status (SES). Coleman's (1988) theory of social capital suggests that context is likely to influence exchanges of capital. Indeed, theory and research suggest that SES may either intensify or compensate for social capital in its relation to socioeconomic attainment. I seek to identify and understand these potential interactions using data from 101,163 participants of the European Social Survey (ESS). Results indicate that while social trust and both absolute and relative social involvement--two common measurements …

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A Digital Application For Assessment Of Neurocognitive Disabilities, Thomas H. Auriemma Jun 2022

A Digital Application For Assessment Of Neurocognitive Disabilities, Thomas H. Auriemma

Theses and Dissertations

Background: Neuropsychological assessment is designed to identify neurocognitive impairment and has traditionally relied on pen-and-paper tests. The behavior collected from these tests is usually expressed as a total summary score or a score that reflects a restricted number of features that assess errors. There is now interest in coupling traditional paper and pencil tests with digital assessment technology. In this context traditional metrics such as summary scores are still available. However, using digital technology, a host of time-based parameters can now be obtained. These time-based parameters include the total time to complete the task or total time to completion, as …

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Do Opposites Attract…Or Aggravate? The Impact Of Intergenerational Solidarity On Well-Being, Rachel K. Scott May 2022

Do Opposites Attract…Or Aggravate? The Impact Of Intergenerational Solidarity On Well-Being, Rachel K. Scott

Theses and Dissertations

Family Systems Theory provides a framework for examining how values are transmitted between family members, and the overall impact transmission has on familial well-being. While familial emotional closeness has been linked to older-adult well-being, there is still a lack of research investigating the influence of ideological agreement between family members. This study examined grandparent-child and grandparent-grandchild dyads to assess the extent to which level of agreement on religious and political ideological beliefs moderates the relation between perceived intergenerational emotional closeness and well-being in grandparents. Affectual solidarity ratings among the generations, as well as religious ideological differences between grandparents and grandchildren, …

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Older Adults Home-Based Care In Cairo: Asset Mapping Towards Community Development, Yomna El-Taweel Apr 2022

Older Adults Home-Based Care In Cairo: Asset Mapping Towards Community Development, Yomna El-Taweel

Theses and Dissertations

The health and economic consequences of the rapid growth of the older adults’ population above 60 have led to new and more flexible forms of care, including home-based care. In Cairo, Egypt, there seems to be a high demand and preference for home-based care services over other care services like nursing homes. From a policy makers’ perspective, older adults’ needs are sometimes approached in a deficit-oriented way. This might contribute to the disempowerment of older adults and make them feel like people with needs that can only be met by external support. This mixed-method study aimed to contribute to the …

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Families In The Sky: Investigating The Population Structure Of Pinus Longaeva, Samuel Arnold Decker Apr 2022

Families In The Sky: Investigating The Population Structure Of Pinus Longaeva, Samuel Arnold Decker

Theses and Dissertations

In the Western United States, the Great Basin is a geographic feature that is home to a variety of unique species, including Great Basin bristlecone pine (Pinus longaeva, PILO). P. longaeva is well known for the age of some of the trees, some of which are over 4000 years old. In this study 17 microsatellite markers (simple sequence repeat, SSR) are identified and used to genotype a selection of 480 individuals spread across 24 PILO populations and 60 individuals divided equally between 2 outgroup species, Pinus aristata and Pinus flexilis. One population of PILO, HMW, shows more genetic similarity with …

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Psychological Distress Of Spousal Caregivers Of Older Adults: The Moderating Role Of Marital Quality, Avalon White Apr 2022

Psychological Distress Of Spousal Caregivers Of Older Adults: The Moderating Role Of Marital Quality, Avalon White

Theses and Dissertations

Caregiving, specifically caregiver burden, is commonly related to decreased psychological well-being. Conversely, marital quality is positively related to psychological well-being, though existing literature presents mixed findings as to whether or not a gender difference exists in this relationship. The current study examined the relationship between objective and subjective spousal caregiver burden and psychological distress with marital quality as a moderator. Gender differences in this relationship were also explored. 1,066 spousal caregivers from the National Study of Caregiving (NSOC) were used to estimate cross-sectional moderation models and plot significant interactions in Mplus. Results indicated a significant positive relationship between subjective caregiver …

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