Digital Commons Network^™

A Network View On Neurodegenerative Disorders, Sreedevi Chandrasekaran

Theses and Dissertations

Neurodegeneration is a chronic, progressive and debilitating condition that affects majority of the World's elderly population who are at greater risk. Numerous scientific studies suggest that there could be a common underlying molecular mechanism that promotes the degeneration and the subsequent neuronal loss, however so far the progress in this direction is rather limited. Abnormal protein misfoldings, as well as protein plaque formations in the brain, are some of the hallmark characteristic features of neurodegenerative disorders (NDDs). Genetic and environmental factors, oxidative stress, excessive reactive oxygen species formation, mitochondrial dysfunction, energy depletion and autophagy disruption etc. are some of the …

Myelin Is Not Required For Maintenance Of The Axon Initial Segment, Anna Josephson

Theses and Dissertations

Axonal pathology is a major contributor to impaired motor, sensory and cognitive dysfunction associated with multiple sclerosis particularly with the progressive forms of the disease. However, the early pathologic events responsible for axonal deterioration remain unclear. It is well recognized that maintaining proper axonal function is intimately related to proper establishment and maintenance of axonal domains such as the node of Ranvier and the axon initial segment (AIS). Numerous laboratories, including ours, have investigated the mechanisms that regulate node of Ranvier formation and maintenance. These studies have shown that node of Ranvier formation and maintenance require myelin contact. Interestingly, many …

"As Mind To The Body": Prudence And Artificial Memory In The Illustrations And Commentary Of George Sandys' Ovid's Metamorphosis Englished (1632), James Hellman

Theses and Dissertations

This thesis is an analysis of an English verse translation of Ovid's Metamorphoses, published in 1632 by the Englishman George Sandys. This book included a full English commentary and was illustrated by several full-plate engravings. This study examines the edition's elaborate utilization of the rhetorical practices of artificial memory and related concepts of rhetorical invention. It demonstrates that these rhetorical practices were chosen and implemented for their inherent structural appropriateness for the cultivation of prudence, or practical wisdom. It reveals that the lessons in practical wisdom encoded in the work through the techniques of artificial memory were particularly aimed at …

Opportunities For The Sustainable Use Of The Camel In Qatar, Corby Jayne Elford

Theses and Dissertations

In the course of the modernization of Qatar, the need for camels has greatly diminished; herds have reduced in numbers and are now confined to enclosures. Overall, neglect of this valuable resource means that the camel is threatened with extinction. Currently, there is a need to address problems about sustainable development in Qatar by taking actions such as investing in the existing natural heritage to develop the use of indigenous animals like the camel. Through a review of past and present use of the native dromedary, a new type of sustainable agritourism will be developed that will provide a type …

Educating Staff Nurses On The Early Recognition Of Clostridium Difficile In Cancer Patients, Jennie A. Meyer

Theses and Dissertations

No abstract provided.

Aicd: A Little Shocking To Your Emotional Health, Lindsay M. Olson

Theses and Dissertations

The treatment of choice for ventricular arrhythmias (VA) and the prevention of sudden cardiac death (SCD) is an Internal Cardioverter Defibrillator (ICD) (Burke, Hallas, Clark-Carter, Whitel, & Connelly, 2003). ICDs are surgically implanted and automatically discharge a 25-35 joule electrical shock directly to the heart if a VA is sensed to convert the heart back to a normal rhythm (Keren, Aaron, & Veltri, 1991). ICDs save people’s lives, yet they can also cause an increased amount of emotional stress, mainly anxiety.

A literature review was conducted to evaluate the emotional impacts of the ICD implantation, shock therapy, and the patient’s …

Effect Of Cannabinoids On Pain-Stimulated And Pain-Depressed Behavior In Rats, Andrew Kwilasz

Theses and Dissertations

Cannabinoids produce antinociception in many preclinical models of acute and chronic pain. In contrast, cannabinoids produce inconsistent analgesia in humans, showing little or no efficacy in treating acute pain, with modest efficacy in treating chronic inflammatory pain. This discrepancy may reflect an overreliance on preclinical assays of pain-stimulated behaviors, defined as behaviors that increase in rate or intensity following delivery of a noxious stimulus. In these assays, antinociception is indicated by a reduction in pain-stimulated behaviors, and antinociception is produced either by a reduction in sensory sensitivity to the noxious stimulus (i.e. true analgesia) or by false positive motor impairment. …

Three-Dimensional Soft Tissue Changes Upon Smiling, Clayton Mcentire

Theses and Dissertations

As esthetic improvement continues to be a primary goal of orthodontic patients and practitioners, it is important to understand the soft tissue movements that occur during the transition from rest to smile. Advances in technology allow capture of 3-dimesional photographs. The purpose of this study was to quantify the soft tissue changes that occur upon smiling and to compare changes between males and females using 3-dimensional photography. Fifty-four participants had resting and smiling photographs taken with the 3dMDface camera system. The two images were registered on stable facial surfaces, landmarks were placed, and measurements were recorded. Three-dimensional changes occurred in …

Land Grab Or Development Planning Strategy: An Analysis Of Agricultural Development Led Industrialization Planning In Ethiopia., Nathan Teklemariam

Theses and Dissertations

Observing the current wave of large scale land acquisitions in Sub-Saharan Africa, many have found it easy to call the situation land grab, the new form of neo colonialism in Africa. In Ethiopia, few underlining socio-economic and political currents have shaped the leasing of its arable land to both national and international investors in recent years. The Agricultural Development Led Industrialization strategy the country adopted in the early 1990s, followed with consecutive short-term strategic plans focused primarily on agriculture as the driver for the nation’s economic growth and structural transformation, have acted as the main underpinnings in the commercialization of …

Risk Factors For Postoperative Cognitive Dysfunction In Older Adults Undergoing Major Noncardiac Surgery, Osama Shoair

Theses and Dissertations

Background: Postoperative cognitive dysfunction (POCD) is a deterioration in cognitive function that occurs after surgery as measured by neuropsychological tests. The purpose of this study was to determine the incidence and risk factors for POCD in older adults three months after major noncardiac surgery. Methods: This is a prospective study of patients aged 65 years and older who underwent major noncardiac surgery. Patients’ cognitive function was assessed before and three months after surgery using a computerized neurocognitive battery. Blood samples were withdrawn from patients before surgery to identify patients with high level of C-reactive protein (CRP), and patients who had …

Bioinformatics Approach To Probe Protein-Protein Interactions: Understanding The Role Of Interfacial Solvent In The Binding Sites Of Protein-Protein Complexes;Network Based Predictions And Analysis Of Human Proteins That Play Critical Roles In Hiv Pathogenesis., Mesay Habtemariam

Theses and Dissertations

The thesis work contains two projects under the same umbrella. The first project is to provide a detailed analysis on the behavior of interfacial water molecules at protein-protein complexes, in this case focusing on homodimeric complexes, and to investigate their effect with respect to different residue types. For that reason the homodimeric data-set, which includes high-resolution (≤ 2.30 Å) X-ray crystal structures of 252 (140 Biological & 112 Non-biological) protein complexes was chosen to explore fundamental differences between interfaces that Nature has “engineered” vs. compared to interfaces found under man-made conditions. The data set was comprised of 5391 water molecules …

Time Dependent Cone-Beam Ct Reconstruction Via A Motion Model Optimized With Forward Iterative Projection Matching, David Staub

Theses and Dissertations

The purpose of this work is to present the development and validation of a novel method for reconstructing time-dependent, or 4D, cone-beam CT (4DCBCT) images. 4DCBCT can have a variety of applications in the radiotherapy of moving targets, such as lung tumors, including treatment planning, dose verification, and real time treatment adaptation. However, in its current incarnation it suffers from poor reconstruction quality and limited temporal resolution that may restrict its efficacy. Our algorithm remedies these issues by deforming a previously acquired high quality reference fan-beam CT (FBCT) to match the projection data in the 4DCBCT data-set, essentially creating a …

Decoding Acting Vocabulary, Daniel Granke

Theses and Dissertations

This paper compares seemingly similar words from a variety of acting teachers, and shows how it is impossible to draw clear comparisons between words that are often used as synonyms. The paper is a reflection of the journey from believing in translation to recognizing its impossibility. In Chapter 1 we focus on one of the most common elements in actor training, Attention/focus/concentration, and analyze the shades of meaning in those words and the difficulty of talking about them in isolation. In Chapter 2 we look at the way in which semiotic analysis can explain the words resistance to equivalence. In …

Reforestation Of Red Spruce (Picea Rubens) On The Cheat Mountain Range, West Virginia, Justin Madron

Theses and Dissertations

The (Plethodon nettingi) Cheat Mountain Salamander is a rare and endangered species that relies heavily on (Picea rubens) Red Spruce for habitat. P. rubens communities on the Cheat Mountain range in West Virginia have been disturbed by fires and logging, and regeneration of P. rubens stands are central to the survival of the P. netting. A supervised and unsupervised landscape classification of three Landsat images over the past 26 years was conducted to analyze change in P. rubens communities on Cheat Mountain Range. Change detection results revealed that from 1986-2012 a 52% growth increase of P. rubens stands, 18% loss, …

Characterizing The Role Of Cdk2ap1 In Primary Human Fibroblasts And Human Embryonic Stem Cells, Khaled Alsayegh

Theses and Dissertations

Cyclin Dependent Kinase-2 Associated Protein-1 (CDK2AP1) plays an important role in cell cycle regulation, by inhibiting CDK2 and by targeting it for proteolysis. It is also known to bind the DNA polymerase alpha-primase complex and regulate the initiation step of DNA synthesis. Its overexpression has been shown to inhibit growth, reduce invasion and increase apoptosis in a number of cancer cell lines. In studies in which mouse embryonic stem cells (mESCs) with targeted deletion of the Cdk2ap1 gene were used, Cdk2ap1 was shown to be required for epigenetic silencing of Oct4 during differentiation. The goal of this thesis was to …

Mimicking The Mechanical Behavior Of Advancing Disc Degeneration Through Needle Injections, Jeremy S. Alsup

Theses and Dissertations

Objective - To investigate the effects of injected protease solution on the mechanical advancement of disc degeneration, and to establish test protocol for future pre-clinical validation of spinal arthroplasty devices. The hypothesis that injection of a protease into a cadaveric lumbar disc will mimic advanced degeneration mechanics was the subject of this study. Summary of Background Information - Spinal disc degeneration is a universal condition that progresses in adults due to aging, disease, or injury. Stages of disc degeneration have been categorized in cadaver specimens, with each degeneration level exhibiting characteristic changes in flexibility parameters. Spinal disc tissue can be …

Effects Of Short-Term Minocycline Treatments On Inflammatory Cell Response In The Acute Stage Following Tbi, Henna Ayub

Theses and Dissertations

Following traumatic brain injury (TBI), neuroinflammation contributes to the secondary injury. Microglia are the resident immune cells of the central nervous system (CNS), and when activated can exert either protective or detrimental effects on surrounding tissue. They are often segregated into subpopulations based on their type of activation, either pro- inflammatory (M1, classically activated), or anti-inflammatory (M2, alternatively activated). Minocycline, an anti-inflammatory drug, is known to be neuroprotective and to have effect on microglia. However, the effect of minocycline on subpopulations of inflammatory cells in the acute stage following injury is unclear. It is also unclear whether minocycline has a …

Camk-Ii: An Integral Protein In Cell Migration, Jamie Josephine Avila Mcleod

Theses and Dissertations

Coordinated inductive and morphogenetic processes of gastrulation establish the zebrafish body plan. Gastrulation includes massive cell rearrangements to generate the three germ layers and shape the embryonic body. Three modes of cell migration must occur during vertebrate gastrulation and include: epiboly, internalization of the presumptive mesendoderm and convergent extension (C&E). C&E movements narrow the germ layers mediolaterally (convergence) and elongate them anteroposteriorly (extension) to define the embryonic axis. The molecular mechanisms regulating coordinated cell migrations remain poorly understand and studying these has become of great interest to researchers. Understanding cell migration during development is highly relevant to a number of …

Birds Of Prey, Shauna Kirkland

Theses and Dissertations

As a child growing up, I was always in love with the ritual of “dress up”. Whether it was my dolls, various reluctant pets, or myself, it was always an activity I loved. It is not surprising then that adornment has become the medium through which I express myself and bring my fantasy world to life. Jewelry and accessory have the potential to lead many lives. One particular piece can change entirely by putting it on one body as opposed to another, or by removing it to see it as an object. In fashion, the body is the canvas and …

The Inflammasome In Acute Myocarditis, Harsha Kannan

Theses and Dissertations

Acute myocarditis is an acute inflammatory syndrome characterized by myocardial damage and dysfunction often due to a viral infection followed by a variable development over time. There are currently no specific treatments and standard treatments for heart failure are generally applied. The inflammasome is a recently identified macromolecular structure that occupies a central role in the amplification of the inflammatory response and promotion of cell death during acute and chronic infections. We hypothesized the formation of the inflammasome in acute myocarditis. To investigate, samples of patients were collected from the Cardiomyopathy Registry in Trieste, with 12 cases of biopsy-proven myocarditis …

Actual Entities: A Control Method For Unmanned Aerial Vehicles, Erica Absetz

Theses and Dissertations

The focus of this thesis is on Actual Entities, a concept created by the philosopher Alfred North Whitehead, and how the concept can be applied to Unmanned Aerial Vehicles as a behavioral control method. Actual Entities are vector based, atomic units that use a method called prehension to observe their environment and react with various actions. When combining multiple Actual Entities a Colony of Prehending Entities is created; when observing their prehensions an intelligent behavior emerges. By applying the characteristics of Actual Entities to Unmanned Aerial Vehicles, specifically in a situation where they are searching for targets, this emergent, intelligent …

Defining The Functions Of A Conserved Hydrophobic Domain In The Arf Tumor Suppressor, Aymen Hariz

Theses and Dissertations

The INK4A-ARF locus encodes two tumor suppressors; p16 and p19Arf, both of which restrain cell growth by regulating the functions of Retinoblastoma (Rb) and p53 respectively. Throughout development, p19Arf is kept at minimal levels, but under conditions of oncogenic stress, p19Arf expression is induced and its tumor suppressive activities are mediated through the stabilization of p53 or in a p53-independent manner. Introducing a point mutation (L46D) into the conserved hydrophobic domain (37-51) in p19Arf annulled ARF/CtBP2 interaction and mediated cell survival by rendering cells irresponsive to apoptosis. In vivo analysis on the percentage of lymphoma free survivals in ARFL46D/L46D mice …

The Activation, Receptor Complexing And Endogenous Regulation Of The Type-I Interferon Response As It Pertains To Innate Immunity, James D. Marion Jr.

Theses and Dissertations

To defend against pathogen challenge, multi-cellular organisms mount an immune response that recognizes, sequesters and eradicates invading infectious agents. Critical to this safeguard is the receptor-mediated detection of pathogens. Pathogen recognition then initiates a variety of signaling cascades that lead to the modulation of genes orchestrating an immune response. Toll-like receptor 3 (TLR3), a transmembrane receptor found in endosomes, is vital to the innate immune response against viruses. Double-stranded RNA (dsRNA) stimulation of TLR3 initiates a signaling cascade that leads to the production of type-I interferons and proinflammatory cytokines necessary to trigger the protective defenses of the immune system. Critical …

Constant Motion, Daniel Rowe

Theses and Dissertations

This thesis contains my writings and concept development, as it relates to personal history, time and animated art. This is explored through various methodologies, including short story and Zen meditative writing. As a companion to my recent thesis exhibition, this paper looks to make logical, emotional and spiritual connections between my art practice, ritualized cultural tropes and contemporary views of mortality.

Art And Becoming-Animal: Reconceptualizing The Animal Imagery In Dorothea Tanning's Post-1955 Paintings, Samantha Karam

Theses and Dissertations

In 1955, American artist Dorothea Tanning abandoned her figurative Surrealist renderings of dream-like scenarios in favor of a complexly abstract and fragmented style of painting. With few exceptions, the ways in which Tanning’s later works function independently of her earlier paintings tends to be downplayed in the scholarship on her oeuvre. Equally sparse is the scholarship on Tanning’s dog imagery, which pervades her oeuvre but becomes most apparent in her later phase. This thesis seeks to shift attention toward Tanning’s later abstract paintings; it also seeks to fill the gap in scholarship on Tanning’s dogs. Specifically, through the study of …

Visual Communication On Cajamarca Ceramics From Pre-Hispanic Peru, 1000 - 1460 Ce, Jeanette Nicewinter

Theses and Dissertations

This project analyzes a database of 118 ceramic sherds that were excavated from the Late Intermediate Period site of Yanaorco, located in the Cajamarca region of the north highlands in present-day Peru, for vessel form, style, and imagery. Through the placement of these sherds within the context of inter-community feasting events that took place at Yanaorco, fineware ceramic vessels are interpreted as prestige items that were utilized by the elite to further differentiate themselves from other community citizens. By examining key examples of representational and non-representational imagery depicted on the sherds, an understanding of the social agency of the vessel …

My Mechanics Of Justification, Veronika Pausova

Theses and Dissertations

This document examines the theory behind the process leading to my paintings, as well as the content of the images I use. The former will invoke romanticism, infinite possibilities, and the need for having certain parameters and flexible rules. The latter will talk about sentimentality and contemporary culture. I will explain the mechanics of justifying the choice of a particular way of painting: the push and pull between the loaded content of an image versus the language of painting itself.

Exhibiting Berthe Morisot After The Advent Of Feminist Art History, Kristie Couser

Theses and Dissertations

Feminist art historians reassessed French Impressionist Berthe Morisot (1841-1895) throughout the late twentieth and early twenty-first century, a period in which her work coincidentally received steady exposure in major museum exhibitions. This thesis examines how the feminist art historical project intersects with exhibitions that give prominence to Morisot’s work. Critical reviews by Morisot scholars argue that more frequent display of the artist’s work has not correlated to nuanced interpretation. Moreover, prominent feminist scholars and museum theorists maintain that curators virtually exclude their contributions. Attending to these recurrent concerns, this thesis charts shifts in emphases and inquiry in writing centered on …

Improving Crowd Simulation With Optimal Acceleration Angles, Movement On 3d Surfaces, And Social Dynamics, Brian C. Ricks

Theses and Dissertations

Crowd simulation plays a critical role in modern films, games, and architectural design. However, despite decades of algorithmic improvements, crowds use sub-optimal heuristics, are primarily constrained to 2D surfaces, and show few if any social dynamics. This dissertation proposes that a solution to these problems lies in altering how each agent perceives its environment as opposed to new obstacle avoidance algorithms. First, this dissertation presents a theoretical look at optimal agent movement. Next, in order to place crowds on arbitrary 3D manifolds, algorithms are proposed that change how each agent perceives its environment. The resulting crowds move naturally across a …

Stalling Life, Leslie Rogers

Theses and Dissertations

Using a diagram, glossary, anecdotes, and first-person narrative histories, I explain how I use sculptural installation, image making, and serendipity to exploit the illogical to the point of being meaningful.