Digital Commons Network^™

Beta 2 Nicotinic Acetylcholine Receptor Contributions To Anxiety-Like Behavior, Shawn Anderson

Theses and Dissertations

Nicotine is a major psychoactive ingredient in tobacco that is thought to promote smoking behavior via nicotinic acetylcholine receptors (nAChRs) in the brain. Given reports that people smoke to relieve anxiety and that anxiety precipitates relapse, the overarching goal of this dissertation research is to assess beta 2 subunit containing nAChR (beta2*nAChR) contributions to anxiety-like behavior. Nicotine’s activity at beta2*nAChRs is concentration-dependent, with high concentrations facilitating activation followed by rapid desensitization and low concentrations preferentially desensitizing beta2*nAChRs; hence, activation or inhibition of beta2*nAChRs may support smoking behavior. Rodent studies reveal that nicotine affects anxiety-like behavior dose-dependently: low doses promote anxiolysis- …

Hot Spot Identification And Analysis Methodology, Jacob S. Farnsworth

Theses and Dissertations

The Utah Department of Transportation (UDOT) Traffic and Safety Division continues to advance the safety of roadway sections throughout the state. To aid UDOT in meeting their goal the Department of Civil and Environmental Engineering at Brigham Young University (BYU) has worked with the Statistics Department in developing analysis tools for safety. The most recent of these tools has been the development of a hierarchical Bayesian Poisson Mixture Model (PMM) statistical model of traffic crashes and safety on UDOT roadways statewide and the integration of the results of this model in a Geographic Information System (GIS) framework. This research focuses …

Analysis And Construction Of Engaging Facial Forms And Expressions: Interdisciplinary Approaches From Art, Anatomy, Engineering, Cultural Studies, And Psychology, Leejin Kim

Theses and Dissertations

The topic of this dissertation is the anatomical, psychological, and cultural examination of a human face in order to effectively construct an anatomy-driven 3D virtual face customization and action model. In order to gain a broad perspective of all aspects of a face, theories and methodology from the fields of art, engineering, anatomy, psychology, and cultural studies have been analyzed and implemented. The computer generated facial customization and action model were designed based on the collected data. Using this customization system, culturally-specific attractive face in Korean popular culture, “kot-mi-nam (flower-like beautiful guy),” was modeled and analyzed as a case study. …

"To Preserve, Protect, And Pass On:" Shirley Plantation As A Historic House Museum, 1894–2013, Kerry Dahm

Theses and Dissertations

This thesis provides an analysis of Shirley Plantation’s operation as a historic house museum from 1894 to the present period, and the Carter family’s dedication to keeping the estate within the family. The first chapter examines Shirley Plantation’s beginnings as a historic house museum as operated by two Carter women, Alice Carter Bransford and Marion Carter Oliver, who inherited the property in the late nineteenth century. The second chapter explores Shirley Plantation’s development as a popular historic site during the mid-twentieth century to the early part of the twenty-first century, and compares the site’s development to the interpretative changes that …

“The Flow Of Blood In Nature” Franz Marc’S Animal Theory, Morgan Rinehart

Theses and Dissertations

This thesis argues for a coherent theory of the animal in the written and visual works of the German Expressionist painter, Franz Marc. By contextualizing Marc’s animal theory within the history of animal studies, this thesis will analyze how Marc’s animal theory corresponds with several central concepts within this field. One of these concepts—a theory of animal death—is central to the artist’s greater theory of the animal and to the analysis this thesis provides. In examining Marc’s theory of animal death, the following work will propose that the artist’s theory of animal spirituality is his greatest legacy within the field …

Novel Liposomes For Targeted Delivery Of Drugs And Plasmids, Marjan Javadi

Theses and Dissertations

People receiving chemotherapy not only suffer from side effects of therapeutics but also must buy expensive drugs. Targeted drug and gene delivery directed to specific tumor-cells is one way to reduce the side effect of drugs and use less amount of therapeutics. In this research, two novel liposomal nanocarriers were developed. This nanocarrier, called an eLiposome, is basically one or more emulsion droplets inside a liposome. Emulsion droplets are made of perfluorocarbons which usually have a high vapor pressure. Calcein (as a model drug) and Paclitaxel were used to demonstrate drug delivery, and plasmids and siRNA were used to exemplify …

Accidental Octopus, Elizabeth Patterson

Theses and Dissertations

I head to the ocean for inspiration. Diving deep, the diverse organic shapes and fluidity of the flora and fauna inspire me to create modular pieces that incorporate intricate line work. This repetitive line and patterning gives me peace and helps me meditate. This self-exploration has opened up a stimulating world that pushes me to produce prints and silver jewelry that are individual and introspective. I have learned that the journey has become the aspiration and the production, a gift.

Alcohol And Medication Use In Community-Dwelling Older Adults: Understanding The Effect Of Alcohol And Central Nervous System-Acting Medications On The Risk For Falls, Maitreyee Mohanty

Theses and Dissertations

Introduction: Aging, comorbid conditions, and use of medications render older adults more susceptible to alcohol-disease or alcohol-drug interactions that may lead to harmful outcomes. In this dissertation project the risk profile of alcohol and medications use among older adults was investigated. Considering the rise in CNS-acting medication use and the adverse effect profile linked to CNS-acting medications, it was also of interest to find if older adults were at risk of falling due to interactions between alcohol and CNS-acting medication. Objectives: The objectives were as follows: 1) to determine the prevalence, pattern and factors associated with at-risk drinking, 2) to …

Beauty In A Crooked Line, Sarah Ramey

Theses and Dissertations

Experimentation is the beginning and end of all of my art. I examine the interactions of the materials that are involved in the journey of creativity. Typically, I begin a piece with an irregularly drawn line, using a white crayon to resist the media that I will later apply, thereby creating a negative line. This gestural line becomes an element that helps direct my intuitive mark-making. My process involves masking, using resists, and layering materials. I then remove the layers of media by scraping or sanding them away changing the texture of the paper. I am drawn to media that …

An Archaeological And Historical Search For German Ethnicity At The Janis-Ziegler Site ( 23 Sg 272 ), Lisa Marie Dretske

Theses and Dissertations

Ste. Genevieve, Missouri is a small town south of St. Louis, settled by the French and home to the Janis-Ziegler site (23SG272). However, the German Ziegler family along with other German families resided in the town beginning in the early nineteenth century. The Ziegler family used the Janis-Ziegler site as a home and a tobacco shop. Beginning in 2006, archaeological investigations went underway on the Janis-Ziegler site. The purpose of this research is to figure out to what degree the Ziegler family showed their ethnicity while living at the Janis-Ziegler house. The second purpose of the research is to figure …

Reflecting On The Ordinary, Linda Conti

Theses and Dissertations

My work is about valuing the ordinary moments in life that can be described as joyful, difficult, beautiful, painful, or even transcendent. My creativity arises from a need to tell the story of these moments, and to share my experience with others. These moments are often evidenced by the objects we leave behind. They are a testament to the life we have lived, or are now living. My attention to small, ordinary details includes honoring and remembering people who have died. They may be artists, writers, friends, or family members but it is important to me to record the unique …

Trajectory Generation And Optimization For Experimental Investigation Of Flapping Flight, Michael Schnebly Wilcox

Theses and Dissertations

Though still in relative infancy, the field of flapping flight has potential to have a far-reaching impact on human life. Nature presents a myriad of examples of successful uses of this locomotion. Human efforts in flapping flight have seen substantial improvement in recent times. Wing kinematics are a key aspect of this study. This study summarizes previous wing trajectory generators and presents a new trajectory generation method built upon previous methods. This includes a novel means of commanding unequal half-stroke durations subject to robotic trajectory continuity requirements. Additionally, previous optimization methods are improved upon. Experimental optimization is performed using the …

Behavioral And Genomic Characterization Of Scheduled Ethanol Deprivation, Jonathan Warner

Theses and Dissertations

Alcoholism is a persistent substance abuse disorder that is associated with negative health, social, and economic outcomes. Treatment strategies for alcohol use disorders are limited, and only three drugs have been approved by the FDA for treatment. Although behavioral therapy and drug combination strategies improve abstinence outcomes, the majority of those in treatment will not achieve long-term abstinence. Therefore, better treatment strategies are needed. While much progress has been made toward understanding the neurobiology of alcoholism, this knowledge has not been effectively translated into treatment strategies. Animal models of alcohol drinking have been crucial to this research effort, but until …

Metergoline, The Basolateral Amygdala And The Ventral Pallidum: Implications For Panic Disorder, Douglas Ryan Schuweiler

Theses and Dissertations

Panic disorder (PD) is a common mental illness characterized by recurring spontaneous panic attacks. Scientific investigation into PD has been accelerated by the development of rat models of PD. These models can be validated by responses to intravenous sodium lactate (NaLac), including tachycardia, that are similar to PD patient responses. Previous work on established PD models has suggested that antagonism of serotonin (5-HT) receptors in the basolateral amygdala (BLA) may be sufficient to model PD. To test this hypothesis metergoline (MET), a 5-HT receptor antagonist, or vehicle was microinjected into the BLA of anesthetized rats. Following the microinjection, NaLac or …

Differences In Attitudes Towards People With Disabilities: Examining The Effects Of The Presence Of An Assistance Dog, Jennifer A. Coleman

Theses and Dissertations

Individuals with disabilities face various types of social stigma. Research suggests that the presence of an assistance dog leads to an increase in social interactions. The purpose of this study was to determine whether people’s attitudes toward individuals with disabilities differ when pairing that person with an assistance dog. Undergraduate students (N= 244) were randomly assigned to view an individual with a disability either alone or with an assistance dog. Participants rated their attitudes toward the individual, completed a newly developed Implicit Association Test, and answered behavioral intention questions. Results of a hierarchical multiple regression analysis indicated that individuals with …

Identifying With The Help: An Examination Of Class, Ethnicity And Gender On A Post-Colonial French Houselot, Erin Nicole Whitson

Theses and Dissertations

The purpose of this study is to attempt to analyze and interpret an outbuilding located in Ste. Genevieve, Missouri, a town established by French settlers in the 1780s. First the functional activities associated with the outbuilding will be determined and examined to best understand where and how the structure fit within the larger property. The activities taking place within/outside the outbuilding--especially those linked to domestic chores--will theoretically paint a clearer picture of who was living and/or working within the structure and who was not. Since little work has been done within the French Mississippi River valley on outbuildings in general, …

Importance Of Merchandising In Affecting Retail Sales, Case Of Medo-Flor, Islam Gjikokaj

Theses and Dissertations

The necessity for this research can be explained by the importance of understanding the interaction between the technical, strategic, and behavioral factors that have been studied and the factors which reflect the merchandising decisions for improving the ambience of the store. Managers of retail stores are continually trying to plan create and control the physical structure of an store but often the impact of a particular effort does not fully satisfy them. The purpose of this study is to investigate the effects of merchandising on retail stores. This study was conducted in Prishtina at Medo-Flor Company. This research consists of …

Siguria Në Sistemet Operative Ios Dhe Android, Atdhe Sefa

Theses and Dissertations

Paisjet mobile Smartphones janë përhapur kudo nëpër botë, Android dhe iOS janë dy sisteme operative celulare më dominuese në treg. Smartphones në bazë të kërkesave të shumta të përdoruesve kanë zhvilluar aplikacione të shumta në mënyrë që shfrytëzuesit të ndihen sa më të kënaqur dhe të plotësuar në kërkesat që celularët e tyre ti ofrojnë shërbime nga më të ndryshmet, dhe mundësitë e përzgjedhjes për smartphones janë të shumta.

Smartphones kanë debutuar me performancë dhe teknologji të sofistikuar dhe shërbimet të cilat mundësohen ofrojnë shumë fleksibilitet. Mirpo niveli i siguris nuk është i mjaftueshëm sulmet janë duke u bërë më …

The Association Between Dairy Consumption And Insulin Resistance, Andrea Rose Erickson

Theses and Dissertations

Background: A cross-sectional design was employed to ascertain the relationship between dairy consumption and insulin resistance (IR) in 272 middle-aged, nondiabetic women. Methods: Participants kept a seven-day weighed food record to report their diets, including consumption of dairy foods. IR was assessed using the homeostatic model assessment (HOMA), using the following formula: fasting plasma insulin (µU/ml) x fasting plasma glucose (mg/dL)/405. The Bod Pod was used to examine body fat percentage, and accelerometry over a seven-day period was used to assess physical activity. HOMA values were log-transformed and regression analysis and the General Linear Model procedure were used to determine …

Analyzing The Functions Of Human Polynucleotide Phosphorylase (Hpnpaseold-35), Upneet K. Sokhi

Theses and Dissertations

RNA degradation plays a fundamental role in maintaining cellular homeostasis, along with being a part of normal regulatory mechanisms, whether it occurs as a surveillance mechanism eliminating aberrant mRNAs or during RNA processing to generate mature transcripts. 3’-5’ exoribonucleases are essential mediators of RNA decay pathways, and one such evolutionarily conserved enzyme is polynucleotide phosphorylase (PNPase). The human homologue of this fascinating enzymatic protein (hPNPaseold-35) was cloned a decade ago in the context of terminal differentiation and senescence through a novel ‘overlapping pathway screening’ approach. Since then, significant insights have been garnered about this exoribonuclease and its repertoire of expanding …

My Inner Mask, Genevieve Ivan

Theses and Dissertations

My work is comprised of masks. The indigenous power of masks inspires the spirit, energy, and soul of my work. I use masks to reveal my inner self, similar to how masks were used in ritual ceremonies in the ancient past. The masks that I create break the grounds of my physical containment and open the curtains of my creative energy and psychological chaos. They allow me to embrace my vulnerability and my strength. My work encompasses prints, paintings, and ceramic sculptures. I work expressively by layering the process of mark making in an intuitive manner. Each layer I create …

Teaching Expressive Writing To High School Students With Learning Disabilities Using Direct Instruction, Self-Regulation, And Computer-Assisted Instruction, William Lindsey

Theses and Dissertations

The purpose of this study was to examine the effects on a combination of Direct Instruction (DI), self-regulation strategies, and computer-assisted writing instruction for high school students with learning disabilities (LD). Five students with LD participated in the study. A multiple baseline research design across students with ABC phases was used. During the baseline, the participants were required to free write 3 to 4 stories based on a topic. During the intervention, the combined strategies were taught, and students were guided to practice in developing their own stories. After two weeks, they were required to complete 2 stories to evaluate …

Personal Characteristics And Learning Preference In End-Of-Life Decision Making Of Chronically Ill Community Dwelling Elders, Leigh Ann Bonney

Theses and Dissertations

Leigh Ann Bonney, RN, MSN; Susan Kossman, RN, PhD; MyoungJin Kim, PhD; Wendy Woith, PhD, Caroline Mallory, PhD

Illinois State University, Mennonite College of Nursing

Personal Characteristics and Learning Preference in End-of-Life Decision Making of

Chronically Ill Community Dwelling Elders

Purpose and Background: Clear decision-making (DM) about end-of-life [EOL] contributes to a good death This requires knowledge of life-sustaining treatment with lack of knowledge contributing to feelings of decisional conflict Decision aids can increase knowledge, but elders' preferred learning methods are unknown. Identifying characteristics associated with preferred learning method and decisional conflict can help nurses tailor information to assist in …

A Molecular Mechanism Regulating The Timing Of Corticogeniculate Innervation, Justin Brooks

Theses and Dissertations

Visual system development requires the formation of precise circuitry in the dorsal lateral geniculate nucleus (dLGN) of the thalamus. Although much work has examined the molecular mechanisms by which retinal axons target and form synapses in dLGN, much less is known about the mechanisms that coordinate the formation of non-retinal inputs in dLGN. These non-retinal inputs represent ~90% of the terminals that form in dLGN. Interestingly, recently reports show that the targeting and formation of retinal and non-retinal inputs are temporally orchestrated. dLGN relay neurons are first innervated by retinal axons, and it is only after retinogeniculate synapses form that …

Experimental And Computational Assessment Of Mechanical Circulatory Assistance Of A Patient-Specific Fontan Vessel Configuration, Steven Chopski

Theses and Dissertations

The treatment of single ventricle anomalies is a formidable challenge for clinical teams caring for patients with congenital heart disease. Those patients fortunate to survive surgical palliation contend with lifelong physical limitations and late stage pathophysiology. A mechanical blood pump specifically designed to increase pressure in the great veins would augment flow through the lungs and provide hemodynamic stability until a donor heart is located. To support the development of such medical devices, this research characterized the fluid dynamics of mechanical assistance in the Fontan circulation by performing numerical analyses and particle image velocimetry (PIV) studies in a patient-specific in …

Thomas Jeckyll, James Mcneill Whistler, And The Harmony In Blue And Gold: The Peacock Room: A Re-Examination, Cynthia Fischer

Theses and Dissertations

This dissertation uncovers three previously unrecognized innovations of Thomas Jeckyll in the Peacock Room. At the same time, the dissertation admits that sometimes James McNeill Whistler chose a more conventional path in the design of the room than previously acknowledged. The dissertation illuminates the often overlooked principle of Classical Decor, first described in the first century BC by Vitruvius, and analyzes how it was instituted in the Peacock Room. Four major points illustrate this conclusion. First, the meaning of the sunflower in the West is explored to account for the flower’s popularity and absorption into ancient heliotropic lore. Thomas Moore’s …

The Effects Of Manipulating Problem Completion Rates On Assignment Choice And Preference Consistency, Kiley Bliss

Theses and Dissertations

A procedure known as mathematics interspersing provides students with additional opportunities (i.e., brief math problems) to complete math problems within an assignment by embedding brief additional problems among longer target problems. Previous research (e.g., Cates & Dalenberg, 2005) found that the more problems completed on an assignment with interspersing, the higher the likelihood the student chooses that assignment relative to an assignment without interspersing. Some students, however, choose assignments without interspersing.

The purpose of this investigation was to focus on students who do not choose assignments (i.e., non-choosers) with interspersing relative to assignments without interspersing and replicate and extend previous …

A Quadruplex Real-Time Pcr Assay For The Rapid Detection And Differentiation Of The Burkholderia Pseudomallei Complex: B. Mallei, B. Pseudomallei, And B. Thailandensis, Chinn-Woan Lowe

Theses and Dissertations

Methods for the rapid detection and differentiation of the Burkholderia pseudomallei complex comprising B. pseudomallei, B. mallei, and B. thailandensis, have been the topic of recent research due to the high degree of phenotypic and genotypic similarities of these species. B. pseudomallei and B. mallei are the causative agents of melioidosis and glanders, respectively. B. pseudomallei and B. mallei are recognized by the CDC as tier 1 select agents. Although B. thailandensis is generally avirulent in mammals, this species displays very similar phenotypic characteristics to that of B. pseudomallei. Optimal identification of these species remains problematic, …

Effects Of Nitrite And Oxygen On Angiogenesis In Vascular Networks Of The Chicken Embryo, Michael Connery

Theses and Dissertations

Nitric oxide (NO) is an important mediator of angiogenesis and is primarily produced endogenously through the action of nitric oxide synthase (NOS). An alternate pathway for NO production is the conversion of nitrite to NO, which depends on the presence of hemoglobin (Hb) and hypoxic conditions. The angiogenic effects of topically applied sodium nitrite on two vascular beds in the ex ovo chicken embryonic model of angiogenesis were assessed. Gas barrier films were used to modulate local oxygen levels in the chorioallantoic membrane (CAM), a respiratory vascular network, and the area vasculosa (AV) on the yolk sac, a typical peripheral …

Cannabinoid Modulation Of Reinforcement Maintained By Stimulation Of The Medial Forebrain Bundle In C57bl/6j Mice, Jason Wiebelhaus

Theses and Dissertations

Cannabinoid agonists, including marijuana containing delta-9-tetrahydrocannabinol (THC), are found rewarding by humans. In addition to human self-reports and experimental studies that show marijuana is rewarding, contributions from preclinical studies also have implicated cannabinoid receptors in reward-motivated behavior. One way to assess these preclinical effects of cannabinoids is intracranial self-stimulation (ICSS), where an animal performs a response to receive electrical stimulation of a specific brain area or circuit known to be involved in reward. Drugs of abuse, such as psychomotor stimulants, facilitate responding for ICSS. While a few studies have shown facilitating effects of cannabinoids in rats, several have shown the …