Digital Commons Network^™

Predictive Modeling Of The Virtual Hemi-Fontan Operation For Second Stage Single Ventricle Palliation: Two Patient-Specific Cases, Ethan Kung, Alessia Baretta, Catriona Baker, Gregory Arbia, Giovanni Biglino, Chiara Corsini, Silvia Schievano, Irene E. Vignon-Clementel, Gabriele Dubini, Giancarlo Pennati, Andrew Taylor, Adam Dorfman, Anthony M. Hlavacek, Alison L. Marsden, Tain-Yen Hsia, Francesco Migliavacca

Publications

Single ventricle hearts are congenital cardiovascular defects in which the heart has only one functional pumping chamber. The treatment for these conditions typically requires a three-staged operative process where Stage 1 is typically achieved by a shunt between the systemic and pulmonary arteries, and Stage 2 by connecting the superior venous return to the pulmonary circulation. Surgically, the Stage 2 circulation can be achieved through a procedure called the Hemi-Fontan, which reconstructs the right atrium and pulmonary artery to allow for an enlarged confluence with the superior vena cava.

Based on pre-operative data obtained from two patients prior to Stage …

In Silico Investigation Of Ph-Dependence Of Prolactin And Human Growth Hormone Binding To Human Prolactin Receptor, Lin Wang, Shawn Witham, Zhe Zhang, Michael E. Hodsdon, Emil Alexov

Publications

Experimental data shows that the binding of human prolactin (hPRL) to human prolactin receptor (hPRLr-ECD) is strongly pH-dependent, while the binding of the same receptor to human growth hormone (hGH) is pH-independent. Here we carry in silico analysis of the molecular effects causing such a difference and reveal the role of individual amino acids. It is shown that the computational modeling correctly predicts experimentally determined pKa’s of histidine residues in an unbound state in the majority of the cases and the pH-dependence of the binding free energy. Structural analysis carried in conjunction with calculated pH-dependence of the binding revealed that …

Teacher's Toolkit: Differentiating Inquiry, Brooke A. Whitworth, Jennifer L. Maeng, Randy L. Bell

Publications

Differentiated instruction and teaching science as inquiry are two pedagogical approaches frequently discussed among science teachers. Teachers know these approaches are important but often have difficulty translating them into their classroom science instruction. This article describes how to differentiate a density investigation for variations in student readiness by varying the level of inquiry using an approach that is easily translated to experiments in any science content area.

Analytic Approximation Of Carbon Condensation Issues In Type Ii Supernovae, Donald D. Clayton

Publications

I present analytic approximations for some issues related to condensation of graphite, TiC, and silicon carbide in oxygen-rich cores of supernovae of Type II. Increased understanding, which mathematical analysis can support, renders researchers more receptive to condensation in O-rich supernova gases. Taking SN 1987A as typical, my first analysis shows why the abundance of CO molecules reaches an early maximum in which free carbon remains more abundant than CO. This analysis clarifies why O-rich gas cannot oxidize C if 56Co radioactivity is as strong as in SN 1987A. My next analysis shows that the CO abundance could be regarded as …

Delphi Web Server: A Comprehensive Online Suite For Electrostatic Calculations Of Biological Macromolecules And Their Complexes., Subhra Sarkar, Shawn Witham, Jie Zhang, Maxim Zhenirovskyy, Walter Rocchia

Publications

Here we report a web server, the DelPhi web server, which utilizes DelPhi program to calculate electrostatic energies and the corresponding electrostatic potential and ionic distributions, and dielectric map. The server provides extra services to fix structural defects, as missing atoms in the structural file and allows for generation of missing hydrogen atoms. The hydrogen placement and the corresponding DelPhi calculations can be done with user selected force field parameters being either Charmm22, Amber98 or OPLS. Upon completion of the calculations, the user is given option to download fixed and protonated structural file, together with the parameter and Delphi output …

Using Delphi Capabilities To Mimic Protein's Conformational Reorganization With Amino Acid Specific Dielectric Constants, Lin Wang, Zhe Zhang, Walter Rocchia, Emil Alexov

Publications

Many molecular events are associated with small or large conformational changes occurring in the corresponding proteins. Modeling such changes is a challenge and requires significant amount of computing time. From point of view of electrostatics, these changes can be viewed as a reorganization of local charges and dipoles in response to the changes of the electrostatic field, if the cause is insertion or deletion of a charged amino acid. Here we report a large scale investigation of modeling the changes of the folding energy due to single mutations involving charged group. This allows the changes of the folding energy to …

Between Algorithm And Model: Different Molecular Surface Definitions For The Poisson-Boltzmann Based Electrostatic Characterization Of Biomolecules In Solution, Sergio Decherchi, José Colmenares, Chiara Eva Catalano, Michela Spagnuolo, Emil Alexov, Walter Rocchia

Publications

The definition of a molecular surface which is physically sound and computationally efficient is a very interesting and long standing problem in the implicit solvent continuum modeling of biomolecular systems as well as in the molecular graphics field. In this work, two molecular surfaces are evaluated with respect to their suitability for electrostatic computation as alternatives to the widely used Connolly-Richards surface: the blobby surface, an implicit Gaussian atom centered surface, and the skin surface. As figures of merit, we considered surface differentiability and surface area continuity with respect to atom positions, and the agreement with explicit solvent simulations. Geometric …

Enduring Quests - Daring Visions (Nasa Astrophysics In The Next Three Decades), Dieter H. Hartmann

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Bright Radio Emission From An Ultraluminous Stellar-Mass Microquasar In M31, Matthew J. Middleton, James C. A. Miller-Jones, Sera Markoff, Rob Fender, Martin Henze, Natasha Hurley-Walker, Anna M. M. Scaife, Timorthy P. Roberts, Dominic Walton, John Carpenter, Jean-Pierre Macquart, Geoffrey C. Bower, Mark Gurwell, Wolfgang Pietsch, Frank Haberl, Jonathan Harris, Michael Daniel, Junayd Miah, Chris Done, John Morgan, Hugh Dickinson, Phil Charles, Vadim Burwitz, Massimo Della Valle, Michael Freyberg, Jochen Greiner, Margarita Hernanz, Dieter H. Hartmann, Despina Hatzidimitriou, Arno Riffeser, Gloria Sala, Stella Seitz, Pablo Reig, Arne Rau, Marina Orio, David Titterington, Keith Grainge

Publications

A subset of ultraluminous X-ray sources (those with luminosities < 10^40 erg s^-1)^1 are thought to be powered by the accretion of gas onto black holes with masses of ~5-20 M⊙, probably via an accretion disc. The X-ray and radio emission are coupled in such Galactic sources, with the radio emission originating in a relativistic jet thought to be launched from the innermost regions near the black hole4,5, with the most powerful emission occurring when the rate of infalling matter approaches a theoretical maximum (the Eddington limit). Only four such maximal sources are known in the Milky Way, and the absorption of soft X-rays in the interstellar medium precludes determining the causal sequence of events that leads to the ejection of the jet. Here we report radio and X-ray observations of a bright new X-ray source whose peak luminosity can exceed 1039 erg s^-1 in the nearby galaxy, M31. The radio luminosity is extremely high and shows variability on a timescale of tens of minutes, arguing that the source is highly compact and powered by accretion close to the Eddington limit onto a stellar mass black hole. Continued radio and X-ray monitoring of such sources should reveal the causal relationship between the accretion flow and the powerful jet emission.

Supersoft X-Rays Reveal A Classical Nova In The M31 Globular Cluster Bol 126, M. Henze, W. Pietsch, F. Haberl, M. Della Valle, A. Riffeser, G. Sala, D. Hatzidimitriou, F. Hofmann, Dieter H. Hartmann, J. Koppenhoefer

Publications

Context. Classical novae (CNe) represent the main class of supersoft X-ray sources (SSSs) in the central region of our neighbouring galaxy M 31. Only three confirmed novae and three SSSs have been discovered in globular clusters (GCs) of any galaxy so far, of which one nova and two SSSs (including the nova) were found in M 31 GCs. Aims. To study the SSS state of CNe we carried out a high-cadence X-ray monitoring of the M 31 central area with XMM-Newton and Chandra. This project is supplemented by regular optical monitoring programmes at various observatories. Methods. We analysed X-ray and …

A Proposed Measure Of Internal Consistency Reliablilty: Coefficient L-Alpha, Todd C. Headrick, Yanyan Sheng

Publications

Data sets in the social and behavioral sciences are often heavy-tailed. Previous studies have demonstrated that small samples or leptokurtic distributions adversely affect the performance of coefficient alpha. To address these concerns, we propose an alternative estimator of reliability based on L-comoments. The empirical results of this study demonstrate that when sample sizes are small and distributions are heavy-tailed that the proposed coefficient L-alpha has substantial advantages over Cronbach’s estimator of reliability in terms of relative bias and relative standard error.

Aviation Maintenance Management, Harry A. Kinnison, Tariq Siddiqui

Publications

Note: This pdf only includes chapter 1 and 18.

THE COMPLETE, UP-TO-DATE GUIDE TO MANAGING AIRCRAFT MAINTENANCE PROGRAMS

Thoroughly revised for the latest aviation industry changes and FAA regulations, this comprehensive reference explains how to establish and run an effi cient, reliable, and cost-effective aircraft maintenance program. Co-written by Embry-Riddle Aeronautical University instructors, Aviation Maintenance Management, Second Edition offers broad, integrated coverage of airline management, aircraft maintenance fundamentals, aviation safety, and the systematic planning and development of successful maintenance programs.

LEARN HOW TO:

• Minimize service interruptions while lowering maintenance and repair costs
• Adhere to aviation industry certification requirements and …

Book Review, Peter H. Huang

Publications

This review of Leo Katz's book, Why the Law is So Perverse, addresses three questions. First, does Katz draw the appropriate normative conclusions about legal perversities based on their connections to social choice theory? In other words, what are the legal ethics and professionalism implications of his book? Second, how does each of the legal perversities in the book follow from a particular social choice theory result? In other words, what is the precise theoretical connection between each of the legal perversities discussed and an impossibility theorem in social choice theory? Third, can we reinterpret our understanding of the …

Contract As Pattern Language, Erik F. Gerding

Publications

Christopher Alexander’s architectural theory of a "pattern language" influenced the development of object-oriented computer programming. This pattern language framework also explains the design of legal contracts. Moreover, the pattern language rubric explains how legal agreements interlock to create complex transactions and how transactions interconnect to create markets. This pattern language framework helps account for evidence, including from the global financial crisis, of failures in modern contract design.

A pattern represents an encapsulated conceptual solution to a recurring design problem. Patterns save architects and designers from having to reinvent the wheel; they can use solutions that evolved over time to address …

The Jury (Or More Accurately The Judge) Is Still Out For Civil Rights And Employment Cases Post-Iqbal, Suzette M. Malveaux

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No abstract provided.

Book Review: Weird Worlds: Bizarre Bodies Of The Solar System And Beyond, T. D. Oswalt

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This document is Dr. Oswalt’s review of Weird Worlds : Bizarre Bodies of the Solar System and Beyond by David A. J. Seargent. Springer, 2013 309p, 1461470633 $34.95, 9781461470632 $34.95.

Elevated Electron Temperatures Around Twin Sporadic E Layers At Low Latitude: Observations And The Case For A Plausible Link To Currents Parallel To The Geomagnetic Field, A. Barjatya, J. P. St. Maurice, C. M. Swenson

Publications

We present data from nighttime sounding rocket flights in the low latitude E region. The payloads carried a sweeping Langmuir probe, a plasma impedance probe, and electric field probes. A detailed examination of the plasma density, temperature, and electric field measurements show two strong sporadic E (Es) layers with very high electron temperatures (∼1000 K) on each side of the upper layer. The lower layer was consistent with the presence of a strong zonal neutral wind shear. The upper layer was strongly influenced by the presence of a strongly negative vertical electric field, with zonal winds and …

Hydrodynamic Modeling Of Ns-Laser Ablation, David Autrique, Vasilios Alexiades, Harihar Khanal

Publications

Laser ablation is a versatile and widespread technique, applied in an increasing number of medical, industrial and analytical applications. A hydrodynamic multiphase model describing nanosecond-laser ablation (ns- LA) is outlined. The model accounts for target heating and mass removal mechanisms as well as plume expansion and plasma formation. A copper target is placed in an ambient environment consisting of helium and irradiated by a nanosecond-laser pulse. The effect of variable laser settings on the ablation process is explored in 1-D numerical simulations.

Time-Stepping For Laser Ablation, Harihar Khanal, David Autrique, Vasilios Alexiades

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Nanosecond laser ablation is a popular technique, applied in many areas of science and technology such as medicine, archaeology, chemistry, environmental and materials sciences. We outline a computational model for radiative and collisional processes occurring during ns-laser ablation, and compare the performance of various low and high order time-stepping algorithms.

Heteroclinic And Homoclinic Connections Between The Sun-Earth Triangular Points And Quasi-Satellite Orbits For Solar Observations, Pedro J. Llanos, Gerald R. Hintz, Martin W. Lo, James K. Miller

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Investigation of new orbit geometries exhibits a very attractive behavior for a spacecraft to monitor space weather coming from the Sun. Several orbit transfer mechanisms are analyzed as potential alternatives to monitor solar activity such as a sub-solar orbit or quasi-satellite orbit and short and long heteroclinic and homoclinic connections between the triangular points L4 and L5 and the collinear point L3 of the CRTBP (circular restricted three-body problem) in the Sun-Earth system. These trajectories could serve as channels through where material can be transported from L5 to L3 by performing small maneuvers at the departure of the Trojan orbit. …

Project Haiti 2012: Providing An Experiential Learning Experience Through The Design And Delivery Of A Water Purifier In Haiti, Yung Wong, Johnathon Camp, Shavin Pinto, Kyle Fennesy, Marc Compere, Yan Tang

Publications

In this paper, we share our experiences and lessons learned from Project Haiti 2012, a project to design and install a water purification system serving 20,000 people per day in the largest tent city in Haiti. Project Haiti 2012 was the third and largest system we have built for Haitians and represents a huge success for all participants and stakeholders. This paper discusses the unique experiential learning opportunity involved in the design and delivery of the water purifier in a foreign developing country. Multiple positive educational, social, and economic outcomes were achieved including students applying knowledge gained from coursework towards …

Walking, Running, And Resting Under Time, Distance And Average Speed Constraints: Optimality Of Walk-Run-Rest Mixtures, Leroy L. Long Iii, Manoj Srinivasan

Publications

On a treadmill, humans switch from walking to running beyond a characteristic transition speed. Here, we study human choice between walking and running in a more ecological (non-treadmill) setting. We asked subjects to travel a given distance overground in a given allowed time duration. During this task, the subjects carried, and could look at, a stop-watch that counted down to zero. As expected, if the total time available were large, humans walk the whole distance. If the time available were small, humans mostly run. For an intermediate total time, humans often use a mixture of walking at a slow speed …

Multi-Instrument Comparisons Of D-Region Plasma Measurements, M. Friedrich, K. M. Torkar, U. P. Hoppe, T. A. Bekkeng, A. Barjatya, M. Rapp

Publications

The ECOMA (Existence and Charge state Of Meteoric dust grains in the middle Atmosphere) series of sounding rocket flights consisted of nine flights with almost identical payload design and flight characteristics. All flights carried a radio wave propagation experiment together with a variety of plasma probes. Three of these measured electron densities, two ion densities. The rockets were all launched from the Andøya Rocket Range, Norway, in four campaigns between 2006 and 2010. Emphasis is on the final three flights from 2010 where the payloads were equipped with four instruments capable of measuring plasma densities in situ, among them a …

A Thermodynamic Analysis Of An Intense North American Arctic Air Mass, Jessica K. Turner, John Gyakum, Shawn M. Milrad

Publications

Northwestern Canada is a genesis region of arctic air masses often considered to be formed primarily through radiative processes. However, the details of their life cycle are poorly understood. This paper examines the formation, maintenance, and dissipation of an intense and long-lived arctic air mass, using a thermodynamic budget analysis.

The airmass formation is characterized by a deep-layer, multistage process that begins with snow falling into a nascent air mass. Radiative cooling from cloud tops begins the process. After the snow abates and clear skies are observed, the surface temperature drops rapidly, aided by the high emissivity of fresh snow …

Visualising Museum Stories, Eoin Kilfeather

Publications

Storytelling is fundamental to our ability to understand, and find meaning in, the world around us. Stories allow us to organise and share knowledge, and to identify the relationships between objects, events, and experiences. Within museums stories allow visitors to engage with collections and to gain meaningful understanding of museum objects. Stories transform a collection of objects into a meaningful knowledge structure that connects the objects and give them meaning.

This paper describes the Open Source Storyscope system that has been developed by the EU FP7 DECIPHER project. Storyscope's workspace and tools allow museum professionals and visitors to research, develop, …

Academic And Social Barriers To Black And Latino Male Collegians' Success In Engineering And Related Stem Fields, Terrell Lamont Strayhorn, Leroy L. Long Iii, Joseph Allen Kitchen, Michael Steven Williams, Meg E. Stenz

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Historically underrepresented racial/ethnic minorities (i.e. African Americans, Latinos, and Native Americans) have experienced barriers to their success in engineering and related STEM fields. These student populations have had lower degree attainment rates, switch to non-STEM majors more frequently, and experience unique social challenges when compared to White and Asian Pacific Islander counterparts. To examine these findings, nearly 50 interviews were conducted and analyzed in the present study to better understand the academic and social experiences of African American and Latino American men in these fields. Interviews revealed that these students tend to (1) feel alone and invisible, (2) lack same …

How Relationships With Faculty And Peers Affect Value Development In Undergraduate Engineering Education: A National Survey Analysis, Leroy L. Long Iii, Michael Steven Williams, Terrell Lamont Strayhorn

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To prepare students for the serious ethical dilemmas encountered in STEM (science, technology, engineering, and mathematics), higher education educators strive to influence students’ value development. Despite this goal, little is known about value development in undergraduate engineering education. Survey data from the 2008-2009 national administration of the revised College Student Experiences in STEM Questionnaire (CSESQ) was analyzed to examine the relationship between students’ engagement with faculty and peers and their perceived value development. Findings from the present study offer insight into (a) engineering students’ value development in college, and (b) the influence of relationships with peers and faculty members on …

Examining Student Success: The Transition From H.S. To College Of First-Year Engineering Students, Leroy L. Long Iii

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To improve retention and graduation rates, institutions of higher education have become increasingly interested in the experiences of first-year students. This is of even greater importance in STEM (science, technology, engineering and mathematics) fields such as engineering which are crucial for U.S. global competitiveness and homeland security. Interviews were conducted with six (6) first-year engineering students at a large, predominantly White land-grant institution located in the Midwestern region of the country to study their decisions and experiences during the transition from high school to college. More specifically, the investigation focused on under-represented students within undergraduate engineering. Interviews focused on three …

Payload Charging Events In The Mesosphere And Their Impact On Langmuir Type Electric Probes, T. A. Bekkeng, Aroh Barjatya, U. P. Hoppe, A. Pedersen, J. I. Moen, M. Friedrich, M. Rapp

Publications

Three sounding rockets were launched from Andøya Rocket Range in the ECOMA campaign in December 2010. The aim was to study the evolution of meteoric smoke particles during a major meteor shower. Of the various instruments onboard the rocket payload, this paper presents the data from a multi-Needle Langmuir Probe (m-NLP) and a charged dust detector. The payload floating potential, as observed using the m-NLP instrument, shows charging events on two of the three flights. These charging events cannot be explained using a simple charging model, and have implications towards the use of fixed bias Langmuir probes on sounding rockets …

Nextgen Flight Deck Data Comm: Auxiliary Synthetic Speech Phase I, Tracy Lennertz, Judith Bürki-Cohen, Andrea L. Sparko, Nickolas D. Macchiarella, Jason Kring, Mike Coman, Tom Haritos, Jeffry Alvarado

Publications

Data Comm—a text-based controller-pilot communication system—is critical to many NextGen improvements. With Data Comm, communication becomes a visual task. Interacting with a visual Data Comm display may yield an unsafe increase in head-down time, particularly for single-pilot operations. This study examined the feasibility of supplementing Data Comm with synthetic speech. To this end, thirty-two pilots flew two experimental scenarios in a Cessna 172 Flight Training Device. In one scenario, ATC communication was with a text-only Data Comm display, in the other, communication was with a text Data Comm display with synthetic speech that read aloud each message (i.e., text+speech). Pilots …