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Highways Of The Mind: The Haunting Of The Superhighway From The World's Fair To The World Wide Web., Helen J. Burgess
Highways Of The Mind: The Haunting Of The Superhighway From The World's Fair To The World Wide Web., Helen J. Burgess
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation investigates the way in which the rhetorical construction of the highway has been haunted, first by narratives of promise and progress and then of decay and death. Highways are figured as technological wonders marking the advent of a better future in the 1939 World's Fair and the advertising campaigns of the 1950s, and then as wired-up networks of death in science fictional accounts from the 60s to the 90s. At stake in this project is the very status of metaphor in the analysis of technology. The highway is a compelling 20th-century metaphor that reveals anxieties we have about …
The Effects Of Science Engineering Mathematics Aerospace Academy (Semaa) Participation On Engagement Rates Of Sixth- And Seventh-Grade Students In Regular Mathematics Classes., Donna R. Carr
Graduate Theses, Dissertations, and Problem Reports (ETD)
The purpose of this study was to investigate the impact of participation in a short-term, co-curricular, mathematics and science program (Science Engineering Mathematics Aerospace Academy, SEMAA) on the engagement rates of sixth and seventh grade students in public school mathematics classes. The outcome variable (engagement) was measured with the Student Record of Behavior at three time intervals. A 22.3 mixed ANOVA design was utilized to investigate three main effects (participation, grade level, and time) and their primary and secondary interactions. Results reflected no discernable impact of the SEMAA program on student engagement rates. Conclusions include alignment of ancillary programs and …
The Effects Of Resistance Training And Oral Creatine Supplementation On Muscle Fiber Morphology, Strength And Activities Of Daily Living In Patients With Charcot -Marie -Tooth Disease., Robert David Chetlin
The Effects Of Resistance Training And Oral Creatine Supplementation On Muscle Fiber Morphology, Strength And Activities Of Daily Living In Patients With Charcot -Marie -Tooth Disease., Robert David Chetlin
Graduate Theses, Dissertations, and Problem Reports (ETD)
Resistance exercise and creatine supplementation independently improve strength and function in patients with neuromuscular diseases, but the effectiveness of the two combined in patients with Charcot-Marie-Tooth (CMT) disease is unknown. Additionally, no study has examined gender differences in strength and activities of daily living (ADLs) in CMT patients before or after resistance training, nor has ADL performance been used for exercise prescription. Purposes. (1) To examine the effects of resistance training with and without creatine supplementation on muscle, strength and function in patients with CMT; (2) To compare effects of 12 weeks training on strength and ADLs in CMT men …
Quid Est Littera? The Materiality Of The Letter And The Presence Of The Past From Alcuin Of York To The "Electronic Beowulf"., Edward J. Christie
Quid Est Littera? The Materiality Of The Letter And The Presence Of The Past From Alcuin Of York To The "Electronic Beowulf"., Edward J. Christie
Graduate Theses, Dissertations, and Problem Reports (ETD)
This dissertation traces the history of the discursive construction of the alphabetic letter in English. Perceived by Anglo-Saxon literati as the “atomic†unit of text, and the “custodian of history,†individual letters were imbued with essential existence that ranked them, like numbers and physical atoms, as fundamental units of matter. In later technological remediations of Anglo-Saxon texts, like the Early Modern production of AElfric's “Easter Sermon†using specially made Anglo-Saxon typefaces, or the digital facsimile of the Beowulf manuscript similar transhistorical properties are imputed to the letter. In the first case, the form of Anglo-Saxon letters becomes the locus of …
The Effects Of Cognitive And Relaxation Interventions On Injured Athletes' Mood, Pain, Optimism, And Adherence To Rehabilitation., Airi Naoi
Graduate Theses, Dissertations, and Problem Reports (ETD)
The present study assessed the effectiveness of cognitive and relaxation interventions on injured athletes' mood, pain, optimism, and adherence and compliance to rehabilitation. The total number of participants who completed this study was seven injured athletes (two females and five males) representing one NCAA Division I university (n = 6) and one NCAA Division II university (n = 1). All athletes incurred their injuries during participation in their sports and had surgery within one month prior to their season or during their competitive season. All participants needed more than 12 weeks for complete recovery after surgery, and they were recruited …
A Grounded Theory Of Moral Reckoning In Nursing., Alvita K. Nathaniel
A Grounded Theory Of Moral Reckoning In Nursing., Alvita K. Nathaniel
Graduate Theses, Dissertations, and Problem Reports (ETD)
Background. Moral distress is a pervasive problem in nursing, contributing to loss of nurses' ethical integrity, dissatisfaction with the work of nursing, and loss of nurses from the workforce. Purpose. The purpose of this research was twofold: to further elucidate the experiences and consequences of professional nurses' moral distress and to formulate a logical, systematic, and explanatory theory of moral distress and its consequences. Methods. This Glasserian grounded theory study utilized volunteer and purposive sampling to recruit a sample of 21 registered nurses. Results. The theory of moral reckoning in nursing illuminates a three-stage process. After a novice period, the …
Lee Hoiby: His Life, His Vocal Writing Style And An Annotation Of Selected Songs For High Voice With Performance Considerations., Colleen Gray Neubert
Lee Hoiby: His Life, His Vocal Writing Style And An Annotation Of Selected Songs For High Voice With Performance Considerations., Colleen Gray Neubert
Graduate Theses, Dissertations, and Problem Reports (ETD)
This research document includes an extensive current biography of Lee Hoiby. A comprehensive list of Hoiby's songs with their dates of composition and revision is also included. Influences on Hoiby's method of composition are discussed as well as his approach to setting text. The analysis of style is examined in broad terms, pointing out characteristics commonly found in Hoiby's songs with examples cited. Eighteen of Hoiby's songs for high voice have been annotated with information that would be of interest to a musician looking for significant new music. In addition to the basic information such as range, tessitura, tempi, duration, …
Roles Of Radicals In Cancer Research: Potential Therapeutic Agents And Probes For Studying Carcinogenesis., Jeannine Harrison Powell
Roles Of Radicals In Cancer Research: Potential Therapeutic Agents And Probes For Studying Carcinogenesis., Jeannine Harrison Powell
Graduate Theses, Dissertations, and Problem Reports (ETD)
Unpaired electrons (radicals) have been implicated in numerous disease processes. They have also been proven useful in the study of intra- and intercellular processes. This work describes two approaches in the study of radicals. The first project involves the synthesis of a spin probe utilizing a stable nitroxide radical to probe DNA structures; the second includes studies of aryl radicals derived from arenediazonium ions found in common foods and other products. Formation of novel DNA structures such as triplex DNA has been associated with inhibited gene transcription and DNA replication. Electron Spin Resonance (ESR) has been used to study spin-labeled …
The Mechanisms Of Ethanol-Induced Damage To The Developing Cerebellum: Effects On The Cerebellar Granule Cells., Zheng Li
Graduate Theses, Dissertations, and Problem Reports (ETD)
Alcohol exposure causes developmental abnormality known as Fetal Alcohol Syndrome (FAS), featured with central nervous system (CNS) dysfunction. The cerebellum is vulnerable to ethanol toxicity. Developmental exposure to ethanol depletes the number of cerebellar granule cells; however, the underlying mechanisms are unknown. A potential mechanism for ethanol-induced neuronal depletion is to reduce the pool of neuronal progenitors. The progression of the cell cycle is regulated by a family of protein kinases called cyclin-dependent kinases (CDKs). We hypothesize that ethanol interferes with the CDK system and disrupts the cell cycle kinetics in cerebellar granule progenitors (CGPs). Pregnant rats were fed ad …
Synthesis Of Novel Heteroaromatic Compounds Structurally Related To Natural Products Via Biradical Cycloaromatizations Of Enyne-Carbodiimides, Enyne-Ketenimines, And Enallene-Isonitriles., Xiaoling Lu
Graduate Theses, Dissertations, and Problem Reports (ETD)
Thermolysis of the benzannulated enyne-carbodiimides provides easy access to a variety of pyrido[1′,2′:1,2]pyrimido[4,5- b]indoles and related heteroaromatic compounds. Methylation of some of these new compounds with methyl iodide occurs exclusively at the site of the indolo nitrogen. The simplicity of the reaction sequence makes the process especially attractive for the synthesis of novel heteroaromatic compounds as potential DNA-intercalating agents. The formation of pyrimido[6 ′,1′:2,3]pyrimido[4,5-b]indoles was unexpected and likely involved a novel [2+2] cycloaddition pathway of the benzannulated enyne-carbodiimides. Similarly, several novel heteroaromatics structurally related to ellipticine alkaloids are synthesized by thermolysis of the pyridannulated enyne-carbodiimides. Two competing reaction pathways involving …
Parent Involvement And The Beginning Teacher: The Story Of Three Elementary Educators., Willard Michael Martin
Parent Involvement And The Beginning Teacher: The Story Of Three Elementary Educators., Willard Michael Martin
Graduate Theses, Dissertations, and Problem Reports (ETD)
Numerous studies conclude that parent involvement in education benefits student achievement and improves the overall quality of schools. However, limited descriptive evidence exists that beginning teachers are being acculturated to parent involvement. The voice of the beginning teacher is relatively silent in the parent involvement literature. Such information could provide school leaders with deeper insight into the impact of parent involvement experiences on beginning teachers and the apparent gulf that exists between preservice training and parent involvement skills required of beginning teachers. The case study approach was used to provide a description of how three beginning, elementary classroom teachers experienced …
The Future Of The University Housing Profession And Implications For Practitioners: A Delphi Study., Beth M. Mccuskey
The Future Of The University Housing Profession And Implications For Practitioners: A Delphi Study., Beth M. Mccuskey
Graduate Theses, Dissertations, and Problem Reports (ETD)
Problem. This study used the Delphi Technique of forecasting and a panel of individuals having the knowledge of the University Housing Profession to ascertain the likelihood of events to happen within the next 20 years and the level of impact of those events upon the profession. Methodology. Six nominators selected for their expertise within the University Housing Profession nominated individuals to serve as expert panelists. Eighty-three individuals were nominated. The 22 individuals with more than two nominations were invited to participate while the remaining panelists were selected randomly. Panelists were either CHO's (Chief Housing Officers) with at least five years …
An Examination Of The Habitat Requirements Of The Endangered Virginia Northern Flying Squirrel (Glaucomys Sabrinus Fuscus) By Assessing Nesting Sites, Habitat Use And The Development Of A Habitat Model., Jennifer M. Menzel
Graduate Theses, Dissertations, and Problem Reports (ETD)
Little is known about nest tree use of the endangered Virginia northern flying squirrel. I compared characteristics of nest trees used by Virginia northern flying squirrels with randomly selected trees during summer and fall of 2000 and 2001. I tracked 13 squirrels to 59 nest trees. Sixty-nine percent of the nests were in cavities and 31% were leaf nests. Yellow birch, black birch and American beech were selected for nest trees more than expected. Nest trees were in larger and taller trees than trees in the surrounding area. There were a significant number of trees located near skidder and hiking …
A Normal Accident Theory-Based Complexity Assessment Methodology For Safety-Related Embedded Computer Systems., John J. Sammarco
A Normal Accident Theory-Based Complexity Assessment Methodology For Safety-Related Embedded Computer Systems., John J. Sammarco
Graduate Theses, Dissertations, and Problem Reports (ETD)
Computer-related accidents have caused injuries and fatalities in numerous applications. Normal Accident Theory (NAT) explains that these accidents are inevitable because of system complexity. Complex systems, such as computer-based systems, are highly interconnected, highly interactive, and tightly coupled. We do not have a scientific methodology to identify and quantify these complexities; specifically, NAT has not been operationalized for computer-based systems. Our research addressed this by operationalizing NAT for the system requirements of safety-related computer systems. It was theorized that there are two types of system complexity: external and internal. External complexity was characterized by three variables: system predictability, observability, and …
The Regulation Of Arachidonic Acid Metabolism In Human Osteoblast-Like Cells., Frank Joseph Secreto
The Regulation Of Arachidonic Acid Metabolism In Human Osteoblast-Like Cells., Frank Joseph Secreto
Graduate Theses, Dissertations, and Problem Reports (ETD)
Reports that estrogen (E2) treatment modulates arachidonic acid (AA) metabolism by bone and bone cells are found in the literature. However, conflicting indications of the relationship that exists between E2 and AA metabolism emerge from the analysis of those reports. The present studies were undertaken to determine if E2 effected the production of prostaglandins (PG) in human osteoblast-like cells (hOB), and if this effect is due to the regulation of key enzymes involved in PG production, namely cytosolic phospholipase A2 (cPLA2) and the cyclooxygenases (COX-1, COX-2). We determined that hOB cells pretreated with E2 and co-stimulated with tumor growth factor-β …
An Analysis Of West Virginia Lamb Marketing Alternatives., Doolarie Singh-Knights
An Analysis Of West Virginia Lamb Marketing Alternatives., Doolarie Singh-Knights
Graduate Theses, Dissertations, and Problem Reports (ETD)
This study provides a comprehensive overview of the current lamb production and marketing environments in WV in view of current and prospective industry changes. Production and marketing inefficiencies, declining demand together with stiff competition from foreign supplies are significant challenges facing the sheep industry. A survey was developed and administered to WV sheep producers to characterize their production and marketing environment, as well as their marketing needs and concerns. Lamb sale transactions from livestock auctions markets in WV were analyzed to determine price trends and price discovery models in the WV sheep industry. The SAS (Statistical Analysis System, 1985) Kruskal-Wallis …
A World Wide Web Broker For Specifications, Methods, And Procedures For Hot Mix Asphalt Concrete Design., Donald Edward Slater
A World Wide Web Broker For Specifications, Methods, And Procedures For Hot Mix Asphalt Concrete Design., Donald Edward Slater
Graduate Theses, Dissertations, and Problem Reports (ETD)
The asphalt paving industry in the United States of America (USA) has no readily available method for evaluating and tracking specifications, methods, and procedures (SMPs) related to hot mix asphalt concrete design. There is no automated or computer assisted way of knowing when specifications, methods, and procedures are changed, revised, replaced, reissued, or discontinued, and when new specifications, methods, and procedures are issued. The problem is linking a user with a specific specification, method, or procedure within a specific source. Evaluation, in the context of this research, applies to the consistency of the inter-relationships among specifications and is not related …
Aquatic-Terrestrial Linkages In Appalachian Streams: Influence Of Riparian Inputs On Stream Habitat, Brook Trout Populations, And Trophic Dynamics., John A. Sweka
Graduate Theses, Dissertations, and Problem Reports (ETD)
Riparian zones play a major role in the structure and function of headwater stream ecosystems. Inputs of leaf litter from riparian zones are the primary energy source for secondary production in these streams and inputs of large woody debris (LWD) help shape stream habitat. Riparian zones of Appalachian streams were degraded by past timber harvest activities. Streamside management zones (SMZs) now protect the riparian zone by limiting timber harvest activities near streams. The objective of this study was to examine aquatic-terrestrial linkages and how habitat and food resources influence brook trout ( Salvelinus fontinalis) populations in Appalachian streams. LWD was …
The Effect Of Emphysema On Adaptation Of Peripheral Skeletal Muscle To Different Loading Conditions In The Syrian Golden Hamster., Anne K. Swisher
The Effect Of Emphysema On Adaptation Of Peripheral Skeletal Muscle To Different Loading Conditions In The Syrian Golden Hamster., Anne K. Swisher
Graduate Theses, Dissertations, and Problem Reports (ETD)
Purpose. Severe emphysema affects peripheral skeletal muscle with only partial reversal with exercise training. The effects of mild emphysema on adaptation of peripheral skeletal muscle to different loading conditions are unknown. Methods. Male Syrian golden hamsters were instilled with saline (S, n = 6) or porcine elastase (E, n = 12) to induce mild emphysema prior to removal of the right Achilles tendon to induce overload (OV) of plantaris muscle and unloading (UL) of gastrocnemius. The left limb served as control (C). Six animals were sacrificed at 1, 3, and 5 months. Fiber type, citrate synthase activity (CS), and capillary …
Distributional Ecology Of Bay Anchovy (Anchoa Mitchilli) In The Hudson River Estuary, United States., Ronald Clifton Tipton
Distributional Ecology Of Bay Anchovy (Anchoa Mitchilli) In The Hudson River Estuary, United States., Ronald Clifton Tipton
Graduate Theses, Dissertations, and Problem Reports (ETD)
We used hydroacoustics to seasonally estimate regional density and combined river region total abundance of larvae, juvenile, and adult bay anchovy in the Hudson River Estuary from May 1996 through September 1998. During the fine scale power plant study, pelagic fish abundance and distribution was determined acoustically in the vicinity of Bowline and Indian Point power plants on the Hudson River, New York during July, August, and September 1996, in a study designed to determine size specific spatial and temporal fish abundance and distribution with respect to environmental classifications in the vicinity of the two power plants. August yielded the …
Zbigniew Brzezinski: The Political And Academic Life Of A Cold War Visionary., Patrick G. Vaughan
Zbigniew Brzezinski: The Political And Academic Life Of A Cold War Visionary., Patrick G. Vaughan
Graduate Theses, Dissertations, and Problem Reports (ETD)
This work examines the political and academic career of Zbigniew Brzezinski. Born in Warsaw in 1928 Brzezinski was a personification of the trials of interwar Poland that would culminate in the combined Nazi-Soviet invasion that would trigger World War II. The son of a Polish diplomat the young Brzezinski witnessed the war from a diplomatic outpost in Montreal where he developed an academic interest in the affairs of the Soviet Union. In 1950 Brzezinski moved on to Harvard where he gained an academic reputation examining the phenomenon of "totalitarianism" and the fragmenting nuances of the Soviet empire in Eastern Europe. …
Examining Stages In Curriculum Change: Implementation Of Complementary And Alternative Medicine (Cam)., Ester L. Verhovsek
Examining Stages In Curriculum Change: Implementation Of Complementary And Alternative Medicine (Cam)., Ester L. Verhovsek
Graduate Theses, Dissertations, and Problem Reports (ETD)
The practice of medicine is changing radically and there is a substantial gap in the practice of medicine and the current curricular models used. As higher education faculty attempt major curriculum transformations, it is crucial to examine the various influences and their ability to progress from the initiation stage to adoption. The purpose of this study was to identify the external and internal influences that most affected the successful transition from the initiation to the adoption of a CAM curriculum change. These influences were examined within the context of complementary and alternative medicine (CAM) so administrators and faculty will have …
The Life Cycle Of A Coal Town: Widen, West Virginia, 1911-1963, Amanda J. Griffith
The Life Cycle Of A Coal Town: Widen, West Virginia, 1911-1963, Amanda J. Griffith
Graduate Theses, Dissertations, and Problem Reports (ETD)
The Elk River Coal and Lumber Company and its president, Joseph Gardner Bradley, built the town of Widen located in Clay County, West Virginia. As coal production proved successful, the coal town rapidly grew and by 1950, Widen offered amenities such as a Y.M.C.A., theater, soda fountain, schools, and churches for the diverse composition of miners to enjoy. In 1952, a fifteen-month strike marked the climax of the history of Widen. The struggle between the local union, known as the League of Widen Miners, and the United Mine Workers of America, resulted in the destruction of company and private property, …
Dark Wilderness A Phenomenological Exploration Of The Idea Of Cave Wilderness, Patricia E. Seiser
Dark Wilderness A Phenomenological Exploration Of The Idea Of Cave Wilderness, Patricia E. Seiser
Graduate Theses, Dissertations, and Problem Reports (ETD)
It has been almost forty years since the passage of the 1964 Wilderness Act and the establishment of the National Wilderness Preservation System. Forty years later, we still have not seen a wilderness that is not a surface environment. There exist neither subterranean nor marine wilderness areas. Efforts on behalf of cave wilderness have focused on the 1964 Wilderness Act legal definition of wilderness. Perhaps what is required is a different concept for the establishment of cave wilderness. This study explored the idea of cave wilderness from a human dimension perspective, via focus groups, using stakeholders from two cave regions …
The Influence Of The Monitoring Process On Special Education Services In West Virginia., Judith Hale Robertson
The Influence Of The Monitoring Process On Special Education Services In West Virginia., Judith Hale Robertson
Graduate Theses, Dissertations, and Problem Reports (ETD)
The purpose of this study was to investigate the effectiveness of the West Virginia Department of Education, Office of Special Education's monitoring system in bringing district special education programs into compliance with federal and state standards. Data for the study were obtained by surveying special education directors (22), special education teachers (848), and parents of students with exceptionalities (2,410) from 22 county school systems in West Virginia. The monitoring report for each of the 22 counties for the 1997–1998 and 1998–1999 school years and the previous monitoring report were analyzed. The 1996–1997 federal Office of Special Education Programs monitoring report …
The Impact Of Past Dating Relationship Solidarity On Commitment, Satisfaction, Investment And Maintenance In Current Relationships., Andy J. Merolla
The Impact Of Past Dating Relationship Solidarity On Commitment, Satisfaction, Investment And Maintenance In Current Relationships., Andy J. Merolla
Graduate Theses, Dissertations, and Problem Reports (ETD)
The purpose of this study was to determine how previous romantic relationships impact subsequent romantic relationships. Specifically, this study examined if past relationship solidarity is related to current relationship commitment, satisfaction, investment, and maintenance behavior usage among individuals in dating relationships. Participants were 204 undergraduates at an Eastern university who were currently in a dating relationship. Results indicated that past relationship solidarity is significantly and negatively related to current relationship commitment and satisfaction, but not significantly related to current investment or maintenance behavior usage. Several mediating variables were also examined, including the nature and attribution of individuals’ breakups, the length …
The Impact Of Caloric Preloading On Attempts At Food- And Eating-Related Thought Suppression In Restrained And Unrestrained Eaters., Cara Frances O'Connell
The Impact Of Caloric Preloading On Attempts At Food- And Eating-Related Thought Suppression In Restrained And Unrestrained Eaters., Cara Frances O'Connell
Graduate Theses, Dissertations, and Problem Reports (ETD)
The current study examined the relation between dietary restraint and caloric preload in thought suppression attempts. The impact of restraint status, suppression instructions, and a high calorie preload were examined among a sample of 64 college females classified as either restrained or unrestrained eaters. Participants engaged in a 60-minute laboratory activity; half of the participants were preloaded and all participants were randomly assigned to a food- and eatingrelated thought suppression condition or an expression control group. Difficulty of suppression and frequency of foods and eating-related thoughts were examined. Restrained participants instructed to suppress demonstrated significantly more food- and eating-related thoughts. …
The Influence Of Birth Order On Verbal Aggressiveness And Argumentativeness., Marissa F. Rodgers
The Influence Of Birth Order On Verbal Aggressiveness And Argumentativeness., Marissa F. Rodgers
Graduate Theses, Dissertations, and Problem Reports (ETD)
This study examined the influence of birth order on verbal aggressiveness and argumentativeness. Participants were 207 (111 men, 94 women; M age = 19.80) students. Participants completed the Verbal Aggressiveness Scale (Infante & Wigley, 1986) and the Argumentativeness Scale (Infante & Rancer, 1982). Results indicated first-born children reported significantly more argumentativeness than did youngest children. Men reported significantly more verbal aggressiveness and argumentativeness than females. A significant difference did not exist between the verbal aggressiveness of first-born children, only-children, and laterborn children. Future research should compare siblings’ reports of verbal aggressiveness, argumentativeness, and other salient communication behaviors to assess differing …
Communication Apprehension And Accuracy Of Decoding Nonverbal Signals: A Replication And Extension Of Schroeder And Ketrow (1997)., Abigail L. Sopko
Communication Apprehension And Accuracy Of Decoding Nonverbal Signals: A Replication And Extension Of Schroeder And Ketrow (1997)., Abigail L. Sopko
Graduate Theses, Dissertations, and Problem Reports (ETD)
This study was intended to be a replication and extension of Schroeder and Ketrow’s study (1997) of communication apprehension and nonverbal decoding ability, using the Interpersonal Perception Task -15 (Costanzo & Archer, 1993). This study explored specific nonverbal behaviors that are utilized by individuals who report high levels of communication apprehension when making judgments about an interaction. Moreover, the relationship between nonverbal decoding ability and interaction involvement was investigated. Results did not indicate any relationship between individuals’ scores on the IPT-15 and any other variable included in the study. Future research should attempt to develop a more reliable and valid …
Uric Acid As An Antioxidant And The Effect Of Changes In Plasma Uric Acid Concentrations On Broiler Susceptibility To Ascites, And, The Effect Of Diet And Strain On Growth, Feed Efficiency, And Amino Acid Retention In Hybrid Bluegill., Beth M. Stinefelt
Graduate Theses, Dissertations, and Problem Reports (ETD)
Study one investigated the ability of uric acid (UA) to scavenge reactive oxygen species (ROS) and the ability of UA to protect against ROS-mediated damage. Hydroxyl and superoxide radical ESR signals were reduced by addition of UA (P< 0.05). UA prevented lipid peroxidation in RAW 264.7 cells exposed to silica (P< 0.015). UA inhibited hydroxyl-mediated damage to λ Hind III DNA. The objective of study two was to determine the effect of changes in plasma UA (PUA) on growth and ascites development in broilers. Chicks were fed a grower diet supplemented with 0.5 moles inosine/kg feed to raise PUA, 15 mg allopurinol/kg body weight/day to lower PUA, or a control diet. Birds were housed in two environmental chambers; one had conditions to promote ascites while the second was held at standard conditions. Although dietary treatment had an effect on PUA, no effect of diet on performance or development of ascites was observed.