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Graduate Theses, Dissertations, and Problem Reports (ETD)

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Reciprocity With The Researcher: An Experimental Manipulation To Increase Help-Seeking In Adults 60 And Older, Elizabeth C. Price Jan 2015

Reciprocity With The Researcher: An Experimental Manipulation To Increase Help-Seeking In Adults 60 And Older, Elizabeth C. Price

Graduate Theses, Dissertations, and Problem Reports (ETD)

Seeking help is one way that individuals can maintain and achieve goals, but older adults may be reluctant to ask for help if they feel they cannot give anything in return. Men or individuals who endorse traditional beliefs about masculine behavior may be less likely than other individuals to ask for help. The first aim of the present study was to determine if a brief experimental manipulation based on the norm of reciprocity could increase help-seeking behavior and improve attitudes toward seeking help in older men and women. A second aim was to examine the relation between traditional beliefs about …

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Victorians Thinking Globally: Identity And Empire In Middle-Class Reading, Jessica A. Queener Jan 2015

Victorians Thinking Globally: Identity And Empire In Middle-Class Reading, Jessica A. Queener

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation argues that popular literature defined how English readers should reconcile a class-based experience of empire with the broadest categories of national identity meant to unify the subjects of the British Empire. Serial genres---periodicals and novels published in numbers---examined new patterns of travel, new approaches to social problems, and the new opportunities empire created for members of the middle class. Spanning the period from roughly 1840 to 1870, each chapter examines a narrative trope used to engage Victorian readers with the concerns of empire, and thus give them an opportunity to imagine the greater world they were given access …

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A Simulation Model For The Procedure Of Psychiatric Patients' Diversion At William R. Sharpe, Jr. Hospital Using Flocking Algorithm For Input Modeling, Aida Rabiee Gohar Jan 2015

A Simulation Model For The Procedure Of Psychiatric Patients' Diversion At William R. Sharpe, Jr. Hospital Using Flocking Algorithm For Input Modeling, Aida Rabiee Gohar

Graduate Theses, Dissertations, and Problem Reports (ETD)

The high rate of civil commitment in West Virginia indicates that the bureau of mental health in the state has been inefficient and unproductive at facilitating the procedures of mental health system delivery, to the point that the two state hospitals of West Virginia are often at their full capacity and incapable of admitting any new cases. This inadequacy at managing psychiatric emergencies causes frequent diversion of civil committed patients from the state psychiatric hospitals to other community psychiatric units, and ultimately costs the state an un-budgeted {dollar}4 million annually.;The main objective of this research is to contribute to the …

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Evolution Of Z ~ 0 Luminous Compact Blue Galaxies, Katherine Rabidoux Jan 2015

Evolution Of Z ~ 0 Luminous Compact Blue Galaxies, Katherine Rabidoux

Graduate Theses, Dissertations, and Problem Reports (ETD)

Luminous compact blue galaxies (LCBGs) are bright (MB ≤ --18.5), blue (B -- V ≤ 0.6), massive (M* ∼ 10 9 M[special character omitted]) star-forming galaxies with high B-band surface brightnesses (SBe(B) ≤ 21.0) that were common at z ∼ 1 when the Universe was half of its current age, but are rare in the local Universe. In this thesis, I have conducted studies of the atomic neutral hydrogen (H I) and global star formation properties of a group of the rare z ∼ 0 analogs to the common z ∼ 1 LCBGs to better understand how this class of …

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Promoting Parents' And Children's Well-Being Through Parent-Child Gratitude Interventions, Meagan A. Ramsey Jan 2015

Promoting Parents' And Children's Well-Being Through Parent-Child Gratitude Interventions, Meagan A. Ramsey

Graduate Theses, Dissertations, and Problem Reports (ETD)

Gratitude is a positive emotion that leads to enhanced relationship resources and emotional well-being for children and adults alike. Given the many benefits of gratitude, researchers have examined several types of gratitude interventions. However, it is unclear how the effectiveness of different gratitude interventions compare for youth or how these interventions operate in the family setting. Therefore, this study examined how parents could cultivate their children's (ages 8-13) gratitude and how two gratitude interventions---counting blessings and relational gratitude---enhanced parents' and children's daily gratitude, relationship satisfaction, and emotional well-being over the course of a week-long intervention and if effects were maintained …

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How To Mitigate Coal Mine Bumps Through Understanding The Violent Failure Of Coal Specimens, Gamal Rashed Jan 2015

How To Mitigate Coal Mine Bumps Through Understanding The Violent Failure Of Coal Specimens, Gamal Rashed

Graduate Theses, Dissertations, and Problem Reports (ETD)

Coal mine bumps have presented serious mining problems for many years. These sudden violent failures around underground mine openings have compromised safety, ventilation and access to mine workings. There is general agreement among researchers that both geologic and poor/inappropriate mining conditions that create high stresses in the pillar are the main causative factors for coal bumps.;The main objective of this research is to understand bump mechanisms in laboratory settings through examining the violent failure of coal specimens and to test three hypotheses to mitigate that violent failure. Also, man-made concrete specimens were prepared and tested to simulate failures in underground …

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Comparing Diel Cycles Of Dissolved Inorganic Carbon To Diel Cycles Of Fe And Mn At A Coal Mine Drainage Site In Harrison Co., Wv, Jill L. Riddell Jan 2015

Comparing Diel Cycles Of Dissolved Inorganic Carbon To Diel Cycles Of Fe And Mn At A Coal Mine Drainage Site In Harrison Co., Wv, Jill L. Riddell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Diel (24 hour) cycles of dissolved inorganic carbon and dissolved metals have rarely been studied in concert in coal mine drainage systems containing high CO2. Diel samples were collected from two locations at a site with elevated CO2; the locations differed in their CO 2 concentrations and the amount of vegetation present. Field data and samples were collected from both locations during March, May, and July 2014. To determine if the parameters cycled in a diel fashion, the data were fit using a cosine model and the goodness of fit was determined using an f-test statistic. Overall, 15 of 20 …

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Illustrating Appalachia: The Sketchbooks And Publications Of David Hunter Strother, 1833 To 1887, Alee Robins Jan 2015

Illustrating Appalachia: The Sketchbooks And Publications Of David Hunter Strother, 1833 To 1887, Alee Robins

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the mid-nineteenth century, one of the most popular American magazine illustrators was David Hunter Strother, a native of Martinsburg, Virginia (now West Virginia). Using the pseudonym "Porte Crayon," Strother published semi-fictional accounts of his travels which he often illustrated as well as authored. The West Virginia & Regional History Center offers a digital collection of 730 of the artist's sketches and paintings. Additionally, the Walters Art Museum presents eight of Strother's sketches online. To provide a method for studying Strother's artworks, a database was created to show connections between the artist's works based on date, location, and thematic content. …

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Quantitative Assessment Of The Discrimination Potential Of Class And Randomly Acquired Characteristics For Crime Scene Quality Shoeprints, Nicole Richetelli Jan 2015

Quantitative Assessment Of The Discrimination Potential Of Class And Randomly Acquired Characteristics For Crime Scene Quality Shoeprints, Nicole Richetelli

Graduate Theses, Dissertations, and Problem Reports (ETD)

Footwear evidence has tremendous forensic value; it can focus a criminal investigation, link suspects to scenes, help reconstruct a series of events, or otherwise provide information vital to the successful resolution of a case. When considering the specific utility of a linkage, the strength of the connection between the source footwear and an impression left at the scene of a crime varies with the known rarity of the shoeprint itself, which is a function of the class characteristics, as well as the complexity, clarity, and quality of randomly acquired characteristics (RACs) available for analysis. To help elucidate the discrimination potential …

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The Anti-Imperialist Empire: Soviet Nationality Policies Under Brezhnev, Jason A. Roberts Jan 2015

The Anti-Imperialist Empire: Soviet Nationality Policies Under Brezhnev, Jason A. Roberts

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation argues that the Soviet Union functioned as an empire despite its decidedly anti-imperialist rhetoric. Beginning in the 1920s, Bolshevik policies transformed the former Russian Empire into a new type of empire that was based on Marxist-Leninist ideology. Moreover, the Bolshevik policy of korenizatsiia as well as Marxist-Leninist rhetoric promoted the development of a decolonization process among the non-Russian peoples of the USSR in the 1920s and 1930s. Although Stalin abandoned korenizatsiia in the 1930s in favor of greater emphasis on Russification, the decolonization process continued into the Brezhnev period of the 1960s and 1970s. This decolonization process quickly …

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The Role Of Police And Courts In The Implementation Of Domestic Violence Policy In Brazil, Ellen Belchior Rodrigues Jan 2015

The Role Of Police And Courts In The Implementation Of Domestic Violence Policy In Brazil, Ellen Belchior Rodrigues

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation investigated factors that influence the decision-making process of police officers, prosecutors, public attorneys and judges when dealing with cases of domestic violence. The study specifically looked at the types of information the police and the judiciary considered relevant to ask victims when they filed complaints at police stations and at court hearings, respectively. Based on the literature on judicial politics and policing, this research focused on how individuals act as agents, helping or hindering the implementation of the policy. It highlighted the various factors that influence these agents, particularly in the context of small communities such as courts …

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A Heterogeneous Aerial Platform Mission Planner Using A Genetic Algorithm, Jonathan Rojas Jan 2015

A Heterogeneous Aerial Platform Mission Planner Using A Genetic Algorithm, Jonathan Rojas

Graduate Theses, Dissertations, and Problem Reports (ETD)

Systems exist today that can plan a mission with more than one aircraft efficiently for surveillance. However, objectives in these missions do not change and are typically performed using a homogeneous set of aerial vehicles. An adaptive mission planner was sought to task a heterogeneous set of Unmanned Aerial Vehicles (UAVs) when an unknown Target of Interest (TOI) is located amongst a set of Points of Interest (POIs). First, two dimensional flight path models of fixed wing and quadcopter platforms were created. Next, the design of a genetic algorithm and its fitness functions were studied. Fixed wing fitness functions were …

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Against The Thalassocracy: Sacred Geography, Nationhood And Perennial Traditionalism In Alexander Dugin's Neo-Eurasianist Philosophy, Jonathan Rushbrook Jan 2015

Against The Thalassocracy: Sacred Geography, Nationhood And Perennial Traditionalism In Alexander Dugin's Neo-Eurasianist Philosophy, Jonathan Rushbrook

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis discusses the ideological makeup of the Russian right wing philosopher Alexander Dugin's and his conceptualization of race and nation in his Neo-Eurasianist imperial project. Tracing Dugin's ideological influences from early Eurasianism, the European New Right and esoteric religious beliefs such as Perennial Traditionalism, the thesis then goes on to place Dugin's body of thought within a larger debate on defining fascism and whether Dugin can be considered a fascist. Ultimately this thesis contests some scholars' interpretations of Dugin's worldview as a fundamentally ethnocentric or even racist Russian nationalism. Rather, by examining Dugin's writings on nation through an ethno-symbolist …

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Drug Use And The Risk Of Motor Vehicle Collision In Adults 65 Years Of Age And Older, Toni Marie Rudisill Jan 2015

Drug Use And The Risk Of Motor Vehicle Collision In Adults 65 Years Of Age And Older, Toni Marie Rudisill

Graduate Theses, Dissertations, and Problem Reports (ETD)

Introduction: The population of adults 65 years of age and older is growing at an exponential rate in the United States. The current generation of older adults is more mobile and driving much later in life compared to previous cohorts. While the current generation of older adults is living longer, they are not necessarily healthier. Older adults consume roughly 30% of all written prescriptions, are the largest consumers of over-the-counter medications, and report a higher prevalence of lifetime licit and illicit drug use compared to previous generations. There is concern that many older adults will drive while taking drugs-either illicit …

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An Ideal Role, Twenty Years Too Soon: A Young Actor's Journey Through The Role Of Leonard In "Seminar", Nicholas Ryan Jan 2015

An Ideal Role, Twenty Years Too Soon: A Young Actor's Journey Through The Role Of Leonard In "Seminar", Nicholas Ryan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Through our production of Seminar, unique challenges were uncovered for an actor performing the role of Leonard. My goal is to examine some of the most difficult and interesting challenges that arose from an unrealistic casting of a realistic play. Issues discussed will be the age gap between Leonard and the students, and what contextually needs to be researched from the script. This examination also addresses the balance of comedy versus drama in regards to Leonard's character relationships with the students, and Leonard's place as a stock character in contemporary theater.

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Theory Of Flame Propagation In Open Obstructed Channels, Jad Sadek Jan 2015

Theory Of Flame Propagation In Open Obstructed Channels, Jad Sadek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Obstructed pipes constitute one of the most relevant configurations for extremely fast premixed flame acceleration and deflagration-to-detonation transition. While the flame propagation through obstacles is often associated with turbulence and/or shocks, a conceptually-laminar and shockless mechanism of extremely fast flame acceleration in semi-open "tooth-brush"-like obstructed pipes has been developed by Bychkov et al [ Phys. Rev. Lett. 101 (2008) 164501]. Namely, a flame front is ignited at the closed end of a pipe, with the flame propagating towards the open pipe end. This acceleration scenario is devoted to a powerful jet-flow, which is produced by delayed combustion in the spaces …

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Kinematic Basis For Body Specific Locomotor Mechanics And Perturbation Responses, Ryan B. Ross Jan 2015

Kinematic Basis For Body Specific Locomotor Mechanics And Perturbation Responses, Ryan B. Ross

Graduate Theses, Dissertations, and Problem Reports (ETD)

Animals have evolved mechanical and neural strategies for locomotion in almost every environment, overcoming the complexities of their habitats using specializations in body structure and animal behavior. These specializations are created by neural networks responsible for generating and altering muscle activation. Species specific musculoskeletal anatomy and physiology determine how locomotion is controlled through the transformation of motor patterns into body movements. Furthermore, when these species specific locomotor systems encounter perturbations during running and walking their behavioral and mechanical attributes determine how stability is established during and after the perturbation. It is still not understood how species specific structural and behavioral …

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Spatial And Temporal Investigation Of Real World Crosswind Effects On Transient Aerodynamic Drag Losses In Heavy Duty Truck Trailers In The Us, Bharadwaj Sathiamoorthy Jan 2015

Spatial And Temporal Investigation Of Real World Crosswind Effects On Transient Aerodynamic Drag Losses In Heavy Duty Truck Trailers In The Us, Bharadwaj Sathiamoorthy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Decreasing truck fuel usage and climate change gas production is of national and global importance. This study focuses on large, heavy-duty on-road tractor trailer combinations because of their impact in terms of fuel consumption levels, emissions, and their dominance in freight transportation in the United States, which offers substantial potential to improve efficiency of the transportation sector and reduce emissions. The US Department of Energy completed a study of this topic in 2009, and the EPA and NHTSA are both engaged in regulating truck efficiency. The Energy Information Administration (EIA) reported that more than 50 percent of the total diesel …

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The Use Of Concept Mappingpattern Matching To Conceptualize The Desired Domain Of Student Learning In The First Year Of College, Jacob B. Sanwidi Jan 2015

The Use Of Concept Mappingpattern Matching To Conceptualize The Desired Domain Of Student Learning In The First Year Of College, Jacob B. Sanwidi

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study conceptualized the desired domain of student learning in the first year of college as it pertains to a success program serving first-time, full-time undecided students at a land-grant and high research activity classified university. Trochim's Concept Mapping/Pattern Matching approach, an exploratory mixed methods research methodology, was used to collect and analyze data. The researcher sought the contribution of 23 participants including sixteen students, and seven faculty and staff members involved in the success program. As a group, participants generated 100 statements representing desired learning outcomes. They individually sorted the items into groups and rated them for relative importance …

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Rechargeable Lithium-Sulfur Batteries With High Sulfur-Loading Electrodes, Jianhua Yan Jan 2015

Rechargeable Lithium-Sulfur Batteries With High Sulfur-Loading Electrodes, Jianhua Yan

Graduate Theses, Dissertations, and Problem Reports (ETD)

Energy is one of the biggest challenges that mankind has been faced for many years. The ever-growing demand for energy is coupled with environmental concerns associated with the excessive use of fossil fuels such as coal, oil and gas. The development of new energy storage device with high energy density has unparalleled advantages in terms of easing the energy crisis and decreasing environmental pollution, and fueling the various energy applications. As one of the prospective energy storage systems, rechargeable lithium-sulfur (Li-S) batteries offer possibilities of low cost and high energy density since sulfur offers a high theoretical capacity of 1672 …

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Protest Tactics And Motivations Surrounding Mountaintop Removal Mining In West Virginia, Craig Zell Jan 2015

Protest Tactics And Motivations Surrounding Mountaintop Removal Mining In West Virginia, Craig Zell

Graduate Theses, Dissertations, and Problem Reports (ETD)

Social movements have been studied in a wide variety of ways. From the use of resource mobilization and political opportunity structure to the new social movement theories. In my paper I discuss how the use of identity and tactics is crucial in understanding how the social movement surrounding anti-mountaintop removal mining in West Virginia works. I studied two groups within this particular movement that use very different tactics as means to the same end. By analyzing them with the use of NSM theory I show how a multi-group approach to studying social movements gives a lot of information on the …

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Emotion Regulation Flexibility And Illicit Substance Use Among Adolescents, Chit Yuen Yi Jan 2015

Emotion Regulation Flexibility And Illicit Substance Use Among Adolescents, Chit Yuen Yi

Graduate Theses, Dissertations, and Problem Reports (ETD)

The purpose of the present study was to investigate how emotion regulation (ER) flexibility was related to illicit substance use among adolescents. The hypotheses were that higher levels of ER flexibility (indicated by higher levels of context sensitivity, a larger ER repertoire, and higher levels of responsiveness to feedback about ER) would be associated with lower levels of substance use, fewer substance-related problems, and lower tendency to use substances in emotion-laden situations. In an online survey, adolescent participants (aged 18 - 20; M = 19.00; SD = 0.74; 77.1% female) answered questions about emotion regulation, illicit substance involvement and other …

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New Experimental Approach To Measure Petrophysical Properties Of Organic-Rich Shales, Mehrdad Zamirian Jan 2015

New Experimental Approach To Measure Petrophysical Properties Of Organic-Rich Shales, Mehrdad Zamirian

Graduate Theses, Dissertations, and Problem Reports (ETD)

Production from hydrocarbon reservoirs is strongly dependent on the permeability of the formation. For decades, the permeability of conventional reservoirs, which are typically in milli-Darcy range, has been measured by the steady-state laboratory technique which provides accurate and fast results. In contrast, unsteady state techniques such as GRI or pulse decay have been used to measure the permeability of unconventional formations such as shales due to their ultra-low permeability. GRI technique is carried on crushed samples and is considered a fast technique for matrix permeability measurement. However, recent studies have found that reported GRI measurements results by different commercial laboratories …

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Perceptions Of Wood Product Supply And Demand For Affordable Building And Green Construction Markets, Gregory D. Estep Jan 2015

Perceptions Of Wood Product Supply And Demand For Affordable Building And Green Construction Markets, Gregory D. Estep

Graduate Theses, Dissertations, and Problem Reports (ETD)

Decreased housing starts between 2005 and 2012 have caused decreased demand for wood-based products such as flooring, cabinetry, and moulding produced from Appalachian hardwoods. However, there may be opportunities to increase demand for these products as demand in the green building sector increases within the United States. Due to this increased demand in green building, wood product manufacturers are presented with an opportunity to further diversify their sales portfolios. The overall goal of this research was to identify wood product opportunities within the affordable and green building industries. Through surveying techniques and spatial analysis of existing commercial green building projects, …

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Piece-Wise Linear Support Vector Machine To Classify Distributed Data, Nafiseh Salmani Niyasar Jan 2015

Piece-Wise Linear Support Vector Machine To Classify Distributed Data, Nafiseh Salmani Niyasar

Graduate Theses, Dissertations, and Problem Reports (ETD)

Support Vector Machines (SVMs) is a popular and highly performing classification model with a very good generalization ability for many classification applications. This method uses kernels to classify data that are not linearly separable. The added complexity of the kernels that map data to a higher dimensional space degrade the SVM classifier performance when dealing with large datasets. Moreover, classifying a dataset by choosing an appropriate kernel and finding the best set of its parameters is challenging. Failing in this process can easily cause to an overfit problem.;In this thesis we propose the Piece-wise Linear SVM (PWLSVM) using MagKmeans clustering …

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Communicating To Resolve The "Mommy Wars": Testing Communicated Stereotypes And The Common Ingroup Identity Model With Stay-At-Home And Working Mothers, Kelly G. Odenweller Jan 2015

Communicating To Resolve The "Mommy Wars": Testing Communicated Stereotypes And The Common Ingroup Identity Model With Stay-At-Home And Working Mothers, Kelly G. Odenweller

Graduate Theses, Dissertations, and Problem Reports (ETD)

Toward empirically validating motherhood as an intergroup context and uncovering communicative solutions to resolving the cultural "mommy wars," the goal of this dissertation was to test foundational intergroup communication theories with stay-at-home mothers (SAHMs) and working mothers (WMs) across two independent experiments. In Study One, participant SAHMs and WMs (N = 529) reported on their outgroup attitudes, affective responses (i.e., contempt, admiration, envy, and pity), behavioral responses (i.e., active/passive facilitation, active/passive harm), intergroup anxiety, and willingness to communicate after viewing a description of a target SAHM or WM designed in accordance with the most prevalent stereotypes of SAHMs and WMs …

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Changing Vulnerabilities In A Changing Climate: Farming Opportunity And Constraint In Kilimanjaro Region, Tanzania, Paul O'Keefe Jan 2015

Changing Vulnerabilities In A Changing Climate: Farming Opportunity And Constraint In Kilimanjaro Region, Tanzania, Paul O'Keefe

Graduate Theses, Dissertations, and Problem Reports (ETD)

This dissertation demonstrates that the vulnerability of households to both socioeconomic and environmental processes is found in unequal, differentiated ability to access the means of social production and reproduction. Place specific environmental and social factors co-produce specific manifestations of vulnerability, but the underlying causes and driving forces are to be found in the social formation and social relations of households in the case study area. The major finding of this dissertation is that changes in the social relations of production and reproduction are creating as much risk to livelihoods as climate change does, or is likely to do in the …

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Synthesis, Characterization And Photocatalytic Activity Of Au-Zno Heterostructures, Oshadha Kanchana Ranasingha Jan 2015

Synthesis, Characterization And Photocatalytic Activity Of Au-Zno Heterostructures, Oshadha Kanchana Ranasingha

Graduate Theses, Dissertations, and Problem Reports (ETD)

Heterostructures of semiconductor metal oxides and metals have been studied extensively due to the synergistic photocatalytic activity they display. Gold-Zinc oxide (Au-ZnO) heterostructured photocatalysts are one of the most widely studied photocatalysts due to the high photocatalytic activity of ZnO and the ability of Au to transfer photoexcited electrons away from ZnO, which leads to enhanced carrier separation and improved catalytic activity. Au heterostructuring is also known to alter the electronic structure of ZnO leading to better photochemical band alignment and a decreased work function which both contribute to enhanced catalytic activity. The use of Au to form heterostructures with …

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Dynamic Assessment Of Induced Stresses And In-Situ Stress Reorientation During Multistage Hydraulic Fracturing In Unconventional Reservoirs, Liliia Reddy Jan 2015

Dynamic Assessment Of Induced Stresses And In-Situ Stress Reorientation During Multistage Hydraulic Fracturing In Unconventional Reservoirs, Liliia Reddy

Graduate Theses, Dissertations, and Problem Reports (ETD)

This research has been dedicated to the optimization of multi-stage hydraulic fracturing by providing a more thorough understanding of fracture and reservoir stress behavior. This work was accomplished by the use of a fully coupled fracture propagation simulator (HFWVU2D developed under RPSEA (Grant/Contract No. #9122-06)) that couples fracture mechanics and fluid dynamics, unlike past studies, which observe only simple interactions. The underlying objective is to eliminate the misappropriated energy caused by inter-fracture stress interaction and stress reorientation surrounding the induced fracture network by assessing stress magnitude as a function of operation conditions.;This study is based upon an in-house numerical simulation …

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Using Enhanced Sampling Molecular Dynamics To Probe The Binding Process Of The Membrane Insertion Peptide Phlip, Yue Ren Jan 2015

Using Enhanced Sampling Molecular Dynamics To Probe The Binding Process Of The Membrane Insertion Peptide Phlip, Yue Ren

Graduate Theses, Dissertations, and Problem Reports (ETD)

Peptides with the ability to bind and insert into the cell membrane are an ever-growing field of research due to their potential biomedical applications. pH (Low) Insertion Peptide (pHLIP), which is a water-soluble polypeptide derived from helix C of bacteriorhodopsin, has the ability to insert into a membrane at acidic pH to form a stable transmembrane alpha-helix. The insertion process takes place in three stages: pHLIP is unstructured and soluble in water at neutral pH (state I), unstructured and bound to the surface of a membrane at neutral pH (state II), and inserted into the membrane as an alpha-helix at …

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