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On Generalizations Of Supereulerian Graphs, Sulin Song Jan 2022

On Generalizations Of Supereulerian Graphs, Sulin Song

Graduate Theses, Dissertations, and Problem Reports (ETD)

A graph is supereulerian if it has a spanning closed trail. Pulleyblank in 1979 showed that determining whether a graph is supereulerian, even when restricted to planar graphs, is NP-complete. Let $\kappa'(G)$ and $\delta(G)$ be the edge-connectivity and the minimum degree of a graph $G$, respectively. For integers $s \ge 0$ and $t \ge 0$, a graph $G$ is $(s,t)$-supereulerian if for any disjoint edge sets $X, Y \subseteq E(G)$ with $|X|\le s$ and $|Y|\le t$, $G$ has a spanning closed trail that contains $X$ and avoids $Y$. This dissertation is devoted to providing some results on $(s,t)$-supereulerian graphs and …


Navigating Abrupt Shifts In Contextual Discourses During A Pandemic And Lack Of Mentorship: A Preservice Teacher’S Journey Developing Critical Pedagogical Discourses, Casey L. King Jan 2022

Navigating Abrupt Shifts In Contextual Discourses During A Pandemic And Lack Of Mentorship: A Preservice Teacher’S Journey Developing Critical Pedagogical Discourses, Casey L. King

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study is centered on one English language arts (ELA) preservice teacher’s development of her critical pedagogical discourses (CPD) with the contextual discourses of a school placement for preservice teaching and later shift to a full-time teacher before the placement was complete during a pandemic and in the midst of implementing online learning. Data is drawn from a 4-month interpretive qualitative case study that included classroom observations and semi-structured interviews. The objective for this study included how a preservice teacher uses their beliefs and identity about instruction amid changing contextual discourses in a pandemic and with a lack of mentorship. …


Multisided Quality Inspection In Smart Manufacturing Systems, Milica Babic Jan 2022

Multisided Quality Inspection In Smart Manufacturing Systems, Milica Babic

Graduate Theses, Dissertations, and Problem Reports (ETD)

As technology advances so does its adoption in industry and our everyday lives. We use technology to better our daily tasks whether at home or in the workplace. In the workplace there are many benefits of implementing new technologies to improve processes and products while at the same time being cautious about associated costs. Costs associated with incorporating new digital technologies include but are not limited to hardware and software, system integration, testing, and employee training. Now that we have entered the era of the Fourth Industrial Revolution, there are many opportunities for improvements in manufacturing that involve Smart Digital …


Understanding Surface Water--Groundwater Connectivity And Discharge In Arctic Deltas, Lindsey N. Aman Jan 2022

Understanding Surface Water--Groundwater Connectivity And Discharge In Arctic Deltas, Lindsey N. Aman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Increased warming is driving unprecedented hydrologic changes within arctic deltas with implications for water storage, solute processing, and terrestrial and marine ecology. Thermokarst lakes within Arctic deltas store flood waters and filter solutes and sediments, thus moderating the impact of flood water discharge to arctic seas. However, this moderating influence is diminishing as lakes shrink on annual and seasonal time scales, especially close to active channels where lakes are shrinking most rapidly. This study investigates surface water-groundwater connectivity in arctic delta plains with coupled flow and heat transport models to provide a mechanistic understanding of how lake-channel proximity will impact …


Essays In Urban And Health Economics, Allyssa Ann Wadsworth Jan 2022

Essays In Urban And Health Economics, Allyssa Ann Wadsworth

Graduate Theses, Dissertations, and Problem Reports (ETD)

Chapter 1 analyzes the impact new hospital construction has on neighboring residential real estate prices. In 2017, the Oishei Children’s Hospital was built in downtown Buffalo, New York, representing a new era for women and children’s medical facilities. Individuals working at the old facility now faced the decision of whether to move closer to the new hospital or have a longer commute. Using property sales data, I analyze how Oishei impacts residential property prices with a difference-in-differences hedonic price model while utilizing three unique time treatments and two distance treatments. The opening of Oishei generated a statistically significant percentage increase …


Investigation Of Geomechanical Behavior Of Laminated Rock Mass Through Experimental And Numerical Approach, Qingwen Shi Jan 2022

Investigation Of Geomechanical Behavior Of Laminated Rock Mass Through Experimental And Numerical Approach, Qingwen Shi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Roof failure in the Appalachian underground coal fields occurs often in laminated shale. Laminated shale roof in coal mines fails in unique ways, such as cutter failure or delamination failure. Extensive studies have investigated the influential factors that cause laminated roof failure, which include in-situ stress, entry layout, roof span, and roof support. However, cutter failure continues to occur frequently and erratically. This is due to the lack of in-depth understanding of the inherent properties of the laminations, such as bedding plane strength, matrix strength, and bedding plane spacing, which in turn influence the geomechanical behavior of the laminated rock. …


Reinforcement Learning For Process Control: Applications To Energy Systems, Elijah Ballard Hedrick Jan 2022

Reinforcement Learning For Process Control: Applications To Energy Systems, Elijah Ballard Hedrick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Reinforcement learning (RL) is a machine learning method that has recently seen significant research activity owing to its successes in the areas of robotics and gameplaying (Silver et al., 2017). However, significant challenges exist in the extension of these control methods to process control problems, where state and input signals are nearly always continuous and more stringent performance guarantees are required. The goal of this work is to explore ways that modern RL algorithms can be adapted to handle process control problems; avenues for this work include using RL with existing controllers such as model predictive control (MPC) and adapting …


Phenomic And Genetic Controls Of The Drought Stress Response In Sorghum, Melissa A. Lehrer Jan 2022

Phenomic And Genetic Controls Of The Drought Stress Response In Sorghum, Melissa A. Lehrer

Graduate Theses, Dissertations, and Problem Reports (ETD)

Drought, one of the most common abiotic stressors, is a result of the precipitation and temperature fluctuations influenced by climate change. As consistent weather patterns are crucial for the maintenance of crop yield, drought threatens food security through its impact on plant growth and development. It is essential to ensure the quality, availability, and affordability of grain-based products in the face of climate change due to expectations of population growth. Therefore, shedding light on the mechanisms associated with drought tolerance is integral to maintaining agricultural production under water-limited conditions. My dissertation work aimed to uncover the morphological, physiological, and genetic …


Impact Of Haemonchus Contortus On Feed Efficiency And Feeding Behavior Of Katahdin And Suffolk Lambs, Camren L. Maierle Jan 2022

Impact Of Haemonchus Contortus On Feed Efficiency And Feeding Behavior Of Katahdin And Suffolk Lambs, Camren L. Maierle

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nutritional impact of internal parasitism, specifically Haemonchus contortus (Hc), is a significant contributor to production losses in small ruminants. Both chronic and subclinical infections generate millions of dollars of losses worldwide. Understanding the nutritional impact of Hc on lamb performance is crucial in determining the additional nutrient requirements of infected individuals. The aim of this study was to evaluate nutritional impact of Hc on infected Katahdin lambs with extensive genetic selection for parasite resistance and susceptible Suffolk lambs. Growth, feeding behavior, and feed efficiency (RFI. F:G) were evaluated during artificial Hc infection. Katahdin ewes from the Virginia …


Investigating The Mitochondrial Protein Mitoneet In C. Elegans Models Of Aging And Alzheimer's Disease, Jacob Ryan Boos Jan 2022

Investigating The Mitochondrial Protein Mitoneet In C. Elegans Models Of Aging And Alzheimer's Disease, Jacob Ryan Boos

Graduate Theses, Dissertations, and Problem Reports (ETD)

Oxidative stress is an imbalance between reactive oxygen species production and elimination, favoring the former. Reactive oxygen species serve as important signaling molecules for physiological homeostasis. However, when produced in excess, these once important signaling molecules become detrimental, disrupting cellular functions, and ultimately leading to cell death. In aging, reactive oxygen species production is increased, accompanied with reductions in oxidative stress resistance, increasing the risk for developing age-related diseases including cardiovascular disease, cancer, stroke, and neurodegenerative diseases. The outer mitochondrial membrane iron-sulfur cluster containing protein mitoNEET (CISD1; gene CISD1) has shown to be a mediator of mitochondrial function and …


Development Of Machine Learning Algorithm To Identify High-Emitters From On-Road Data For Heavy-Duty (Hd) Vehicles, Filiz Kazan Jan 2022

Development Of Machine Learning Algorithm To Identify High-Emitters From On-Road Data For Heavy-Duty (Hd) Vehicles, Filiz Kazan

Graduate Theses, Dissertations, and Problem Reports (ETD)

The process of on-road, heavy-duty engine family certification is regulated by the United States Environmental Protection Agency (US EPA). Currently, the US EPA 2010 emissions standards require the threshold from the Federal Testing Procedure (FTP) engine dynamometer cycle to be at or below a brake-specific NOx (bs-NOx) value of 0.20 g/bhp-hr for heavy-duty (HD) engines. The engine manufacturers are also required to conduct in-use portable emission measurement system (PEMS) testing to prove their products' compliance. The selected vehicles are required to satisfy not-to-exceed (NTE) analysis under normal driving conditions in the heavy-duty in-use testing (HDIUT) program. California …


Performance Of Peltier Cooled Technology During Preconcentration Of Volatile Organic Compounds Analyzed By Gas Chromatography-Mass Spectrometry (Gc-Ms) Using Niosh Manual Of Analytical Methods (Nmam) 3900, Elizabeth Ann Fernandez Jan 2022

Performance Of Peltier Cooled Technology During Preconcentration Of Volatile Organic Compounds Analyzed By Gas Chromatography-Mass Spectrometry (Gc-Ms) Using Niosh Manual Of Analytical Methods (Nmam) 3900, Elizabeth Ann Fernandez

Graduate Theses, Dissertations, and Problem Reports (ETD)

Using evacuated canisters for whole-air sampling allows for sampling without specific knowledge of the environment and potential analytes. Evacuated canisters are able to tolerate concentrations ranging from parts per trillion (PPT) to parts per million (PPM). The U.S. Environmental Protection Agency (EPA) has used evacuated canisters for years to sample volatile organic compounds (VOCs) from ambient air using their method TO-15 (LeBouf, et al., 2019). The GC-MS system used for the development of NMAM 3900 used liquid nitrogen to cool sorbent traps in the preconcentrator. Liquid nitrogen allows for cooling of specified points below ambient temperature. An alternative to liquid …


Machine Learning Approach To Health Risk Determination, Levi Butcher Cole Jan 2022

Machine Learning Approach To Health Risk Determination, Levi Butcher Cole

Graduate Theses, Dissertations, and Problem Reports (ETD)

In the United States, cardiovascular disease is the leading cause of death for both men and women. The factors that contribute to heart disease are well known but it is still an ever-evolving field of research. The possible benefits to being able to determine an individual’s Health Risk could provide the early insights needed to combat cardiovascular disease. However, two major problems within this area are the public availability of a dataset and the label imbalances for the dataset. In this thesis, we present a framework for exploring health risk using a combination of the NHANES dataset and open-source machine …


Low-Temperature Hot Corrosion Of Boilers In The Coal-Fired Power Plant, Artem Gavrilev Jan 2022

Low-Temperature Hot Corrosion Of Boilers In The Coal-Fired Power Plant, Artem Gavrilev

Graduate Theses, Dissertations, and Problem Reports (ETD)

Hot corrosion of materials has remained a relevant topic since its introduction in the second half of the 20th century as gas turbine engines suffered severe corrosion during operation over seawater. Hot corrosion is observed in a multitude of high temperature components, such as gas turbines, power plants, refineries, fluidized bed combustion systems, pipelines, and industrial waste incinerators.

Hot corrosion experiments in the laboratory have been conducted under constant temperatures of interest, while in the actual working conditions of coal-fired power plants, boiler tubes are cooled down via water cooling from a relatively high fireside temperature, e.g., 1000°C. To investigate …


Classifying Blood Glucose Levels Through Noninvasive Features, Rishi Reddy Jan 2022

Classifying Blood Glucose Levels Through Noninvasive Features, Rishi Reddy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Blood glucose monitoring is a key process in the prevention and management of certain chronic diseases, such as diabetes. Currently, glucose monitoring for those interested in their blood glucose levels are confronted with options that are primarily invasive and relatively costly. A growing topic of note is the development of non-invasive monitoring methods for blood glucose. This development holds a significant promise for improvement to the quality of life of a significant portion of the population and is overall met with great enthusiasm from the scientific community as well as commercial interest. This work aims to develop a potential pipeline …


Multifunctional Organoboron Compounds And Boralactonate Salts, Randika T. Abeysinghe Jan 2022

Multifunctional Organoboron Compounds And Boralactonate Salts, Randika T. Abeysinghe

Graduate Theses, Dissertations, and Problem Reports (ETD)

Organoboron compounds have gathered an important significance within the chemistry community on account of their wide range of applications in synthesis, catalysis, and medicinal chemistry. Even though the uses of boron compounds in drug discovery have been overlooked until the last several decades, boronic acid containing molecules have garnered increased attention due to the unique chemical properties of the boron center. Boron-functionalized ��-aryl propionic acid non-steroidal anti-inflammatory drug derivatives (bora-NSAIDs) can be accessed via copper(I)-catalyzed alkene boracarboxylation, using CO2 and B2pin2. To explore and expand the current synthetic and future medicinal chemistry applications of these bora-NSAIDs, methods …


Impact Of Radio Frequency Interference And Real-Time Spectral Kurtosis Mitigation, Evan T. Smith Jan 2022

Impact Of Radio Frequency Interference And Real-Time Spectral Kurtosis Mitigation, Evan T. Smith

Graduate Theses, Dissertations, and Problem Reports (ETD)

We catalog the ubiquity of Radio Frequency Interference (RFI) plaguing every modern radio telescope and investigate several ways to mitigate it in order to create better science-ready data products for astronomers. There are a myriad of possible RFI sources, including satellite uplinks and downlinks, cellular communications, air traffic radar, and natural sources such as lightning. Real-time RFI mitigation strategies must take these RFI characteristics into account, as the interfering signals can look significantly different at very high time and frequency resolutions.

We examine Spectral Kurtosis (SK) as a real-time statistical RFI detection method, and compare its flagging efficacy against simulated …


Development Of A Thermal Desalination System Using Low Quality Thermal Energy, Takudzwa C. Chipunza Jan 2022

Development Of A Thermal Desalination System Using Low Quality Thermal Energy, Takudzwa C. Chipunza

Graduate Theses, Dissertations, and Problem Reports (ETD)

Abstract

Development of a Thermal Desalination System Using Low Quality Thermal Energy

Takudzwa Chipunza

The blowdown water from the cooling tower of the power plant and the produced water from shale gas industry cannot be disposed directly to the environment as they may contain dissolved solids that are harmful to the environment. A detailed physical and chemical process to remove the mineral and organic solids has been developed in West Virginia University. Such a process includes running the blowdown and produced water through a softening tank, activated carbon tank, and a reverse osmosis (RO) system. The RO reject contains a …


Invisible Confidence: Developing An Innovative Leotard For Urinary And Menstrual Protection, Desiree' Nicole Childers Jan 2022

Invisible Confidence: Developing An Innovative Leotard For Urinary And Menstrual Protection, Desiree' Nicole Childers

Graduate Theses, Dissertations, and Problem Reports (ETD)

Invisible Confidence: Developing an Innovative Leotard for Urinary and Menstrual Protection

The focus of this thesis project is to develop a multifaceted study, related to leotards in competitive gymnastics and dance with regards to design and construction, use of absorbent fabrics, and product development and marketing. The research for developing this design will include: the exploration into the anesthetic design of the gymnastics leotard, along with the mechanical properties of fabric in the area of absorption and durability, as well as how the construction might affect these aspects, and will explore the steps towards the development and marketing of these …


Mountain Biking Mountaineers: Insights Into The West Virginia Mountain Biking Community, Connor Mullin Jan 2022

Mountain Biking Mountaineers: Insights Into The West Virginia Mountain Biking Community, Connor Mullin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Mountain biking is one of the most popular recreational activities in the United States. Beyond the increasing popularity of the sport, the technology is also changing, especially in terms of electric mountain biking. This new type of bike blends traditional mountain bikes with electric bikes, creating a potential new group of recreationists. The research on mountain biking, and more specifically electric mountain biking, is limited. The purpose of this study is to examine West Virginian mountain bikers by studying behaviors and motivations. There are no published studies focused on mountain biking in West Virginia, and therefore a need to fill …


Repercussions: The Pressure To Be Thin, Shuhan Liu Jan 2022

Repercussions: The Pressure To Be Thin, Shuhan Liu

Graduate Theses, Dissertations, and Problem Reports (ETD)

My MFA thesis and supporting exhibition will highlight ceramics work I have created with the intention of dissecting the relationship between a soul and reality to convey the story of tension and anxiety and show it in a way that would let viewers identify with my discomfort and anxiety. The inspiration for my work came from the severe body anxiety that I faced that broke out during the three years of psychological stress caused by the pandemic. Using personal narratives as a starting point, I created object-based artwork that addresses the external pressures I feel to be skinny. As an …


Developing Artificial Intelligence Tools To Investigate The Phenotypes And Correlates Of Chronic Kidney Disease Patients In West Virginia, Marzieh Amiri Shahbazi Jan 2022

Developing Artificial Intelligence Tools To Investigate The Phenotypes And Correlates Of Chronic Kidney Disease Patients In West Virginia, Marzieh Amiri Shahbazi

Graduate Theses, Dissertations, and Problem Reports (ETD)

ABSTRACT

Developing Artificial Intelligence tools to investigate the phenotypes and correlates of Chronic Kidney Disease patients in West Virginia

Marzieh Amiri Shahbazi

Chronic kidney disease (CKD) is responsible for disrupting the lives of 37 million people just in the USA, which is about 1 in 7 adults. CKD results in a gradual loss of kidney function over time. Sometimes CKD doesn’t produce any significant symptoms until it reaches an advanced stage. On the other hand, acute kidney injury (AKI) accounts for a sudden decline in the kidney’s function. As a result, the kidneys fail to filter waste materials from the …


Computational Analysis Of The Stability Limits Of Premixed Methane-Air Combustion In Micro-Channels, Almoutazbellah Adnan Kutkut Jan 2022

Computational Analysis Of The Stability Limits Of Premixed Methane-Air Combustion In Micro-Channels, Almoutazbellah Adnan Kutkut

Graduate Theses, Dissertations, and Problem Reports (ETD)

Technological progress in the last decades facilitated the development of integrated microsystem devices, including electrical and mechanical components for micro-electro-mechanical systems (MEMS). Such systems necessitate an external power supply, but typical batteries yet have some unavoidable limitations. To address this problem, numerous studies have been conducted to develop alternatives powered by micro combustion – in order to effectively utilize the high-density energy of hydrocarbon fuels. Such a global need has resulted in much more attention devoted to the combustion-based micro-power generation systems. However, to better understand the typical combustion characteristics in such microscale systems, design and performance restrictions need to …


Stylistic Changes In The Music Of Ruth Crawford Seeger, Xinlei Chu Jan 2022

Stylistic Changes In The Music Of Ruth Crawford Seeger, Xinlei Chu

Graduate Theses, Dissertations, and Problem Reports (ETD)

While the body of Ruth Crawford Seeger’s works is not extensive, her musical legacy cannot be ignored. As a central member of the “ultramoderns,” her work influenced the next generation of American composers such as Elliot Carter. This research document examines the stylistic changes of Crawford’s music throughout her career as a composer. Taking into account the various influences that could have impacted her compositional style over time, three pieces were selected for in-depth analysis from different times in Crawford’s life. The first two pieces analyzed are the first movement of Diaphonic Suite No. 2 and the third movement of …


Vaping During Pregnancy: Effects On Vascular And Behavioral Outcomes In Offspring, Eiman A. Aboaziza Jan 2022

Vaping During Pregnancy: Effects On Vascular And Behavioral Outcomes In Offspring, Eiman A. Aboaziza

Graduate Theses, Dissertations, and Problem Reports (ETD)

Electronic cigarette (e-cig) use is increasing due to aggressive marketing, tempting flavors, and seemingly higher acceptability in the community (lesser perceived social stigma) despite unproven claims of safety. In an alarming trend, pregnant women smokers have turned to novel “modified risk” products, such as e-cigs, in response to heavy marketing of e-cigs as safer alternatives to cigarettes and a tool to help quit smoking. This is despite proven detrimental effects of nicotine on a growing fetus, and scarcity of information regarding toxicity of e-liquid (with and without nicotine) on child development. Moreover, rampant e-cig use among youth (nearly 4 million …


Bottleneck Management Through Strategic Sequencing In Smart Manufacturing Systems, Sayantee Roy Jan 2022

Bottleneck Management Through Strategic Sequencing In Smart Manufacturing Systems, Sayantee Roy

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nowadays, industries put a significant emphasis on finding the optimum order for carrying out jobs in sequence. This is a crucial element in determining net productivity. Depending on the demand criterion, all production systems, including flexible manufacturing systems, follow a predefined sequence of job-based machine operations. The complexity of the problem increases with increasing machines and jobs to sequence, demanding the use of an appropriate sequencing technique. The major contribution of this work is to modify an existing algorithm with a very unusual machine setup and find the optimal sequence which will really minimize the makespan. This custom machine setup …


High Precision Pipeline Leak Detection And Localization Using Negative Pressure Wave Technique: An Application In A Real Field Case Study, Nathaniel C. Moryan Jan 2022

High Precision Pipeline Leak Detection And Localization Using Negative Pressure Wave Technique: An Application In A Real Field Case Study, Nathaniel C. Moryan

Graduate Theses, Dissertations, and Problem Reports (ETD)

One of the most important aspects of oil and gas production is the safe and efficient fluid transportation using pipelines. Pipelines transporting various fluids are the most efficient but are susceptible to failure and leaks. These leaks can come about through natural disaster, as well as from general wear from the pipes that could result in major environmental and economic problems. The ability to detect leaks with speed and accuracy, as well as locating these leaks within a narrow range, will aid with the maintenance response. Hasty responses will minimize the revenue loss and reduce potential environmental impact but bring …


The Use Of Neural Networks In Accelerating Small Molecule Docking Of Gpcrs, John Barber Jan 2022

The Use Of Neural Networks In Accelerating Small Molecule Docking Of Gpcrs, John Barber

Graduate Theses, Dissertations, and Problem Reports (ETD)

Docking simulations are a vital virtual screening technique to identify potential drug candidates by predicting the binding score and position for protein-ligand interactions. As ligand libraries expand into the billions, the number of groups able to run these simulations decreases drastically. Here we propose a simple methodology allowing for more accessibility of docking large ligand libraries. This method uses simple molecular features and unsupervised learning to cluster like molecules. These clusters are then randomly sampled, creating a training set. A model is trained using the bag of bonds method and a simple neural network to predict the binding affinity of …


System Development Of An Unmanned Ground Vehicle And Implementation Of An Autonomous Navigation Module In A Mine Environment, Jonas Amoama Bredu Jnr Jan 2022

System Development Of An Unmanned Ground Vehicle And Implementation Of An Autonomous Navigation Module In A Mine Environment, Jonas Amoama Bredu Jnr

Graduate Theses, Dissertations, and Problem Reports (ETD)

There are numerous benefits to the insights gained from the exploration and exploitation of underground mines. There are also great risks and challenges involved, such as accidents that have claimed many lives. To avoid these accidents, inspections of the large mines were carried out by the miners, which is not always economically feasible and puts the safety of the inspectors at risk. Despite the progress in the development of robotic systems, autonomous navigation, localization and mapping algorithms, these environments remain particularly demanding for these systems. The successful implementation of the autonomous unmanned system will allow mine workers to autonomously determine …


Understanding Vaccine-Induced Memory Responses To Develop The Next Generation Of Pertussis Vaccines, Kelly L. Weaver Jan 2022

Understanding Vaccine-Induced Memory Responses To Develop The Next Generation Of Pertussis Vaccines, Kelly L. Weaver

Graduate Theses, Dissertations, and Problem Reports (ETD)

Bordetella pertussis is a Gram-negative respiratory pathogen that can infect individuals of all ages and is notably responsible for infant fatalities. Pertussis (whooping cough) is a vaccine-preventable respiratory disease for which vaccines have been available in the United States since the 1940s. Whole cell pertussis vaccines kept incidence of pertussis under 5,000 cases per year, but were associated with reactogenicity issues. Following the introduction of less reactogenic acellular pertussis vaccines in the late 1990s, there have been noteworthy outbreaks of pertussis. For example, in 2012 there were over 50,000 reported cases of pertussis and 20 deaths in the U.S. The …