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Saprophytic Colonization And Sporulation Of Virulent And Hypovirulent Cryphonectria Parasitica On American Chestnut (Castanea Dentata) And Scarlet Oak (Quercus Coccinea), Eric Shelton Goddard Jan 2015

Saprophytic Colonization And Sporulation Of Virulent And Hypovirulent Cryphonectria Parasitica On American Chestnut (Castanea Dentata) And Scarlet Oak (Quercus Coccinea), Eric Shelton Goddard

Graduate Theses, Dissertations, and Problem Reports (ETD)

Colonization and sporulation (stroma production) of virulent (V) and hypovirulent (HV) Cryphonectria parasitica, were evaluated on two hosts to better understand the saprophytic stage of the fungus and its ability to produce HV inoculum. Both the V and HV C. parasitica strains were isolated from an existing chestnut orchard at the test site. Castanea dentata (American chestnut) and Quercus coccinea (scarlet oak) were used as test hosts. Sixty centimeter long stems of both species were cut from saplings and placed as pairs in three-layer, triangular stacks. Each stack was wound inoculated with either V, HV or water agar (control) inoculum. …

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Development Of A Conservation Action Plan For The Eastern Hellbender (Cryptobranchus Alleganiensis Alleganiensis) In West Virginia, William J. Greathouse Jan 2015

Development Of A Conservation Action Plan For The Eastern Hellbender (Cryptobranchus Alleganiensis Alleganiensis) In West Virginia, William J. Greathouse

Graduate Theses, Dissertations, and Problem Reports (ETD)

The Eastern hellbender (Cryptobranchus alleganiensis alleganiensis ) is the largest salamander in North America growing to 75 centimeters in length. This fully aquatic species is an indicator of good stream and river quality and has been considered to be in decline or rare throughout its range. This study focused on the current distribution of the Eastern hellbender at sites of historic occurrence in West Virginia in order to determine the species' current range and factors impacting its distribution in order to facilitate planned reintroductions and translocations of hellbenders reared in human care. The success of the reintroduction and translocation efforts …

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Assessing Feeder Space Access And Commercial Phytase Production Methods On Performance Of Commercial Broilers Fed Pelleted Diets, Mark Edward Lemons Jan 2015

Assessing Feeder Space Access And Commercial Phytase Production Methods On Performance Of Commercial Broilers Fed Pelleted Diets, Mark Edward Lemons

Graduate Theses, Dissertations, and Problem Reports (ETD)

Applied research conducted at universities is essential for further advancements in poultry science and ultimately the commercial poultry industry. One important area of applied nutrition research is examining production methods associated with the important feed additive/enzyme phytase. Exogenous phytase inclusion in poultry diets has consistently been associated with decreased diet cost, increased broiler performance, and reduction in negative environmental impact. However, thermal stability of commercial phytases are variable. Strategies for production of phytases that ultimately maintain activity after being subjected to the pelleting process is essential. Phytase manufacturers have modified production methods in an effort to maximize phytase thermal stability …

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Rotating Space Elevators: Classical And Statistical Mechanics, Steven Knudsen Jan 2015

Rotating Space Elevators: Classical And Statistical Mechanics, Steven Knudsen

Graduate Theses, Dissertations, and Problem Reports (ETD)

We investigate a novel and unique dynamical system, the Rotating Space Elevator (RSE). The RSE is a multiply rotating system of strings reaching beyond the Earth geo-synchronous satellite orbit. Objects sliding along the RSE string ("climbers") do not require internal engines or propulsion to be transported far away from the Earth's surface. The RSE thus solves a major problem in the space elevator technology which is how to supply the energy to the climbers moving along the string. The RSE is a double rotating floppy string. The RSE can be made in various shapes that are stabilized by an approximate …

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Metal Oxide Nanoparticles: The Importance Of Size, Shape, Chemical Composition, And Valence State In Determining Toxicity, Katherine Dunnick Jan 2015

Metal Oxide Nanoparticles: The Importance Of Size, Shape, Chemical Composition, And Valence State In Determining Toxicity, Katherine Dunnick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Nanoparticles, which are defined as a structure with at least one dimension between 1 and 100 nm, have the potential to be used in a variety of consumer products due to their improved functionality compared to similar particles of larger size. Their small size is associated with increased strength, improved catalytic properties, and increased reactivity; however, their size is also associated with increased toxicity in vitro and in vivo. Numerous toxicological studies have been conducted to determine the properties of nanomaterials that increase their toxicity in order to manufacture new nanomaterials with decreased toxicity. Data indicates that size, shape, chemical …

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Analytical And Computational Methods For The Assessment Of Biological Molecules And Their Binding Interactions: Case Studies In Dna Aptamer-Target Binding And P450-P450 Dimerization, Katherine M. Hickey Jan 2015

Analytical And Computational Methods For The Assessment Of Biological Molecules And Their Binding Interactions: Case Studies In Dna Aptamer-Target Binding And P450-P450 Dimerization, Katherine M. Hickey

Graduate Theses, Dissertations, and Problem Reports (ETD)

A DNA aptamer against atrazine, a small molecule target, was computationally predicted using mfold and RNA fold to generate secondary structure from sequence, and NAB and RNA Composer to subsequently generate tertiary structure, subsequently relaxed, and the most-representative structures docked (AutoDock) with atrazine and simazine. According to analysis with X3DNA, the best predicted structure had the majority of its base-pairing sugars in the 2'-endo conformation, contained multiple helical regions in the B-form. Constrained docking revealed no preference for the target molecule (atrazine) over a negative target (simaxine), in contrast to in vitro binding results, thus more calculations are needed to …

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Evaluation Of Age, Growth And Diet Of Channel Catfish (Ictalurus Punctatus) In Cheat Lake, West Virginia, Corbin D. Hilling Jan 2015

Evaluation Of Age, Growth And Diet Of Channel Catfish (Ictalurus Punctatus) In Cheat Lake, West Virginia, Corbin D. Hilling

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis describes population characteristics of Channel Catfish ( Ictalurus punctatus) in Cheat Lake, West Virginia in two chapters. The first chapter is comprised of a literature review on the ecology, diet and growth of Channel Catfish, as well as the influence of water level fluctuations on biota. The second chapter examines the age, growth and fall diet of Channel Catfish in Cheat Lake, West Virginia. Acidification has historically impaired Cheat Lake's fish community, but recent mitigation efforts within the Cheat River watershed have improved water quality and species richness. Presently, Channel Catfish are abundant and attain desirable sizes for …

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Development Of An Erosion Control Seed Mixture That Includes Native Species, George A. Hilvers Jan 2015

Development Of An Erosion Control Seed Mixture That Includes Native Species, George A. Hilvers

Graduate Theses, Dissertations, and Problem Reports (ETD)

The West Virginia Divisions of Highways (WVDOH) utilizes the establishment of grass cover as a temporary and permanent management practice to mediate the effects of erosion on highway construction sites. Current West Virginia regulations include five seed mixtures for permanent applications that include combinations of nine species. Six of these species are identified as invasive, and all nine species are considered introduced or both native and introduced. This research developed alternative seed mixtures that included low threat or native species. The alternative seed mixtures were then evaluated in a field test. The research also examined seedbed preparation techniques, the performance …

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Myosin Ii Isoforms In Breast Cancer: Role Of Contractility In Matrix Organization, Cell Migration, And Endothelial Barrier Function, Bridget Ruth Hindman Jan 2015

Myosin Ii Isoforms In Breast Cancer: Role Of Contractility In Matrix Organization, Cell Migration, And Endothelial Barrier Function, Bridget Ruth Hindman

Graduate Theses, Dissertations, and Problem Reports (ETD)

Breast cancer is a devastating and complicated disease. A large proportion of breast cancer related deaths are due to metastasis. Metastasis is when cancer cells leave the primary tumor, travel through the bloodstream, and proliferate in distant sites. Cell contractility is involved in a number of cellular processes associated with metastasis including matrix organization, tumor cell migration, and endothelial cell barrier function. The main regulator of contractility in nonmuscle cells is nonmuscle myosin II. There are three isoforms of this protein: myosin IIA, IIB, and IIC. The specific roles of the individual isoforms in cancer progression and metastasis have yet …

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Identification And Biosensing Application Of Molecular Recognition Elements, Ka Lok Hong Jan 2015

Identification And Biosensing Application Of Molecular Recognition Elements, Ka Lok Hong

Graduate Theses, Dissertations, and Problem Reports (ETD)

Molecular recognition elements (MREs) are biomolecules such as single-stranded DNA (ssDNA), RNA, small peptides and antibody fragments that can bind to user defined targets with high affinities and specificities. This binding property allows MREs to have a wide range of applications, including therapeutic, diagnostic, and biosensor applications. The identification of MREs can be achieved by using the process called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). This process begins with a large library of 109 to 1015 different random molecules, molecules that bind to the user defined target or positive target are enriched in the process. Subsequently, this process …

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The Effects Of The Human Voice On The Behavioral Indicators Of Stress In Dogs Housed In An Animal Shelter, Juliana M. Hypes Jan 2015

The Effects Of The Human Voice On The Behavioral Indicators Of Stress In Dogs Housed In An Animal Shelter, Juliana M. Hypes

Graduate Theses, Dissertations, and Problem Reports (ETD)

Animal shelters are very stressful environments for the animals housed there. Dogs that live in shelters have been observed exhibiting stress-related behavior such as barking, pacing, aggression and fear related behaviors such as cowering. Behaviors of this nature are off-putting to prospective adopters. To combat this problem, shelters are using different types of behavioral programs to reduce stress in the kennels. One such program involves human volunteers reading to the dogs. The aim of this study was to determine if listening to the human voice could reduce the expression of stress-related behaviors in shelter dogs. In order to establish the …

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Spirituality, Help-Seeking Attitude, And Black Women: A Qualitative Study, Pamela Lashe Jackson Jan 2015

Spirituality, Help-Seeking Attitude, And Black Women: A Qualitative Study, Pamela Lashe Jackson

Graduate Theses, Dissertations, and Problem Reports (ETD)

A semi-structured interview was used to survey help-seeking attitude via questions about spirituality, therapy, and the connections between the two. Interpretative Phenomenological Analysis (IPA) was used to provide a framework for understanding how these factors potentially effect professional help-seeking attitudes in Black women and the role spirituality plays in developing help-seeking attitudes and the potential effect on professional psychological help. Ten interviews were conducted with Black women who lived or went to church in Akron, Ohio. Data from nine study participants were used and seven super-ordinate themes were found. The themes identified were as follows: 1) awareness and access; 2) …

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Parameter Identification Of Induction Motor, Yousef Abdel-Rehim Jan 2015

Parameter Identification Of Induction Motor, Yousef Abdel-Rehim

Graduate Theses, Dissertations, and Problem Reports (ETD)

Numerous recent techniques of induction motor parameters calculating are hard to be done and expensive. Accurate calculations of the parameters of these motors would allow savings in different prospective like energy and cost. The major problem in calculating induction motor parameters is that it's hard to measure output power precisely and without harm during the operation of the machines. It will be better to find other way to find out the output power with certain amount of inputs like input voltage and current.;Particle swarm optimization (PSO) and genetic algorithms (GAs) are often used to estimate quantities from limited information. They …

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Effect Of Nutrition, Lactation And Gonadotropin Stimulation On Ram-Induced Lh Surge And Subsequent Fertility In Early Post-Partum Ewes During Seasonal Anestrous, Abiodun Emmanuel Adebiyi Jan 2015

Effect Of Nutrition, Lactation And Gonadotropin Stimulation On Ram-Induced Lh Surge And Subsequent Fertility In Early Post-Partum Ewes During Seasonal Anestrous, Abiodun Emmanuel Adebiyi

Graduate Theses, Dissertations, and Problem Reports (ETD)

This study evaluated the effect of lactation, exogenous gonadotropin (GS), and nutritional supplementation (SUPP) on fertility of Katahdin ewes during seasonal anestrous. Experiment 1 evaluated effects of lactation and GS on ram-induced LH surge. Lactating (65 to 80 d postpartum; pp) and dry ewes were randomly assigned to be treated with an estrus induction protocol (EIP) consisting of a 5-d treatment with a CIDR device with an injection of a gonadotropin mixture (240 IU eCG and 120 IU hCG; P.G. 600RTM; 3 ml/animal i.m.; n = 16) or no further treatment (n=16) at removal of CIDRs. Experiment 2 was similar …

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Eco-Town: An Integrated Modeling Framework For Simulating The Effects Of Urban Morphology On Sustainable Development, Ali Abutalebpur Jan 2015

Eco-Town: An Integrated Modeling Framework For Simulating The Effects Of Urban Morphology On Sustainable Development, Ali Abutalebpur

Graduate Theses, Dissertations, and Problem Reports (ETD)

Spatial structure of a city is a key determinant of its socioeconomic well-being and there is a growing interest in models that investigate the relation between spatial structure and sustainable urban development. This dissertation aims to examine the role of urban spatial structure on social, economic, and environmental dimensions of sustainability through developing an integrated modeling framework. In particular, this modeling framework bridges "design of urban built environment" and "sustainable development" at the city-region level through simulation and measuring the effect of changes in urban spatial structure on the stock of various asset forms including natural, human, and physical capital.;The …

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The Longest Common Subsequence Via Generalized Suffix Trees, Tazin Afrin Jan 2015

The Longest Common Subsequence Via Generalized Suffix Trees, Tazin Afrin

Graduate Theses, Dissertations, and Problem Reports (ETD)

Given two strings S1 and S 2, finding the longest common subsequence (LCS) is a classical problem in computer science. Many algorithms have been proposed to find the longest common subsequence between two strings. The most common and widely used method is the dynamic programming approach, which runs in quadratic time and takes quadratic space. Other algorithms have been introduced later to solve the LCS problem in less time and space. In this work, we present a new algorithm to find the longest common subsequence using the generalized suffix tree and directed acyclic graph.;The Generalized suffix tree (GST) is the …

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Diel Periodicity And Chronology Of Upstream Migration In Yellowphase American Eels (Anguilla Rostrata), Joni L. Aldinger Jan 2015

Diel Periodicity And Chronology Of Upstream Migration In Yellowphase American Eels (Anguilla Rostrata), Joni L. Aldinger

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis examined 24-h diel periodicity of upstream migration of yellow-phase American Eels (Anguilla rostrata), and the chronology of upstream movements within diel periods (day, night, and twilight). Further, relationships were examined for total lengths of upstream migrants and diel movements (vespertine, nocturnal, matutinal, and diurnal), as well as for total lengths and season of year. The thesis is comprised of two chapters: (1) an introduction and literature review on American Eel life history, migration and movement, and population concerns, and (2) a research study of diel periodicity and movement chronology of upstream migrant yellow-phase American Eels at an eel …

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Essays On Aesthetics Of Food, Marya Alhelaili Jan 2015

Essays On Aesthetics Of Food, Marya Alhelaili

Graduate Theses, Dissertations, and Problem Reports (ETD)

This thesis is comprised of three essays that explore the aesthetics of food in contemporary food and table setting design. The essays are: (1) Aesthetics of Food (2) Food Design (3) Table Setting Design.;Food is an everyday necessity. With advancements in production and a plentiful supply in developed countries, the preparation of food and its consumption has developed socially and artistically. There is increased emphasis being placed on how to make and present food in nontraditional ways to enhance aesthetic appeal. Yet, there is not consensus about the aesthetic dimensions of food. The viewpoint that food should be considered a …

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Father Involvements Influence On Mother's Perceptions Of Parenting In An Appalachian Sample, Kalynn B. Amick Jan 2015

Father Involvements Influence On Mother's Perceptions Of Parenting In An Appalachian Sample, Kalynn B. Amick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Father involvement in parenting can have a positive influence on both children and mothers. During times of economic stress it may also add to the resources available and make a positive contribution to mothers parenting practices. In this study it was considered how father involvement may influence mother's perceptions of parenting. Specifically, this study looks at father involvement in an Appalachian sample. Five participants completed questionnaires which answered questions about mothers' present perceptions of parenting and father involvement. No significant associations were found between father involvement and mother's perceptions of parenting. Limitations include small sample size and a lack of …

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Spatial And Temporal Distribution Of Hemlock Woolly Adelgid (Hemiptera: Adelgidae) Ovisac And Its Associations With The Environment, Sunghoon Baek Jan 2015

Spatial And Temporal Distribution Of Hemlock Woolly Adelgid (Hemiptera: Adelgidae) Ovisac And Its Associations With The Environment, Sunghoon Baek

Graduate Theses, Dissertations, and Problem Reports (ETD)

Eastern hemlock, Tsuga canadensis (Pinales: Pinaceae) is an important tree species in eastern North America ecosystems. During the past 65 years, eastern hemlock stands have been threatened by the hemlock woolly adelgid, Adelges tsugae Annand (Hemiptera: Adelgidae). The goal of this research was to determine the spatial and temporal distribution of A. tsugae populations. First, the appropriate sample unit for A. tsugae was determined based on within-branch and -tree distribution of A. tsugae. The results of this study showed that A. tsugae ovisacs were more frequently found at the tip of a branch and no significant (P > 0.05) differences in …

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Role Of Multi-Site Phosphorylation In Regulation Of E(Spl) M8 Activity During Drosophila Neurogenesis, Mohna Bandyopadhyay Jan 2015

Role Of Multi-Site Phosphorylation In Regulation Of E(Spl) M8 Activity During Drosophila Neurogenesis, Mohna Bandyopadhyay

Graduate Theses, Dissertations, and Problem Reports (ETD)

Notch signaling is an evolutionarily conserved pathway that regulates cell-fate determination at various stages of development in invertebrate and vertebrate species. The Notch pathway mediates juxtacrine signaling through a process termed as lateral inhibition by which two equipotent cells adopt distinct cell fates. The functions of Notch have been exceptionally well analyzed during neurogenesis in Drosophila, particularly during eye and mechanosensory bristle morphogenesis. At the onset of neurogenesis, proneural bHLH activators encoded by atonal (ato) or the achaete-scute complex (ASC) is expressed in groups of cells, called proneural clusters (PNCs) in the eye and the bristle tissue respectively. From each …

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Parameterized Strings: Algorithms And Applications, Richard Beal Jan 2015

Parameterized Strings: Algorithms And Applications, Richard Beal

Graduate Theses, Dissertations, and Problem Reports (ETD)

The parameterized string (p-string), a generalization of the traditional string, is composed of constant and parameter symbols. A parameterized match (p-match) exists between two p-strings if the constants match exactly and there exists a bijection between the parameter symbols. Historically, p-strings have been employed in source code cloning, plagiarism detection, and structural similarity between biological sequences. By handling the intricacies of the parameterized suffix, we can efficiently address complex applications with data structures also reusable in traditional matching scenarios. In this dissertation, we extend data structures for p-strings (and variants) to address sophisticated string computations.;We introduce a taxonomy of classes …

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Assessing And Meeting Residents' Needs: An Evaluation Of Residence Hall Programming, Michael J. Beck Jan 2015

Assessing And Meeting Residents' Needs: An Evaluation Of Residence Hall Programming, Michael J. Beck

Graduate Theses, Dissertations, and Problem Reports (ETD)

In this qualitative study, I examine how programming in college residence halls does and does not meet the needs of residents and resident assistants. Using focus group and individual interview data, I structure my analysis using Maslow's (1954) hierarchy of needs. I suggest that residence hall programming---academic, social, or a hybrid of the two---is most valuable for its ability to meet residents' needs related to belongingness but that residence hall staff must place more explicit emphasis on residents' growth needs in order for self-actualization to be supported.

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Lead Exposure Of Obligate Avian Scavengers In Eastern North America, Shannon Behmke Jan 2015

Lead Exposure Of Obligate Avian Scavengers In Eastern North America, Shannon Behmke

Graduate Theses, Dissertations, and Problem Reports (ETD)

Lead is a toxic element within the body of living organisms. Lead poisoning cases still occur in both humans and wildlife on a regular basis in the United States. Although the harmful effects of lead within the body are well known, such as decreased IQ in children, increased renal dysfunction, hypertension, anemia, and other morbid and mortal consequences in humans and wildlife, lead continues to be used in anthropogenic activities today. Through the use of lead in ammunition and fishing sinkers, and its presence in coal-fired power plant and other industrial emissions, lead is dispersed throughout modern human and natural …

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Types Of Co-Existing Chronic Physical Conditions And Newly-Diagnosed Depression, Its Treatment And Economic Outcomes Among Medicaid Beneficiaries With Type 2 Diabetes, Rituparna Bhattacharya Jan 2015

Types Of Co-Existing Chronic Physical Conditions And Newly-Diagnosed Depression, Its Treatment And Economic Outcomes Among Medicaid Beneficiaries With Type 2 Diabetes, Rituparna Bhattacharya

Graduate Theses, Dissertations, and Problem Reports (ETD)

Diabetes is a widely prevalent metabolic condition. Adults with type 2 diabetes mellitus (T2DM) also have many coexisting chronic physical conditions. Coexisting chronic physical conditions among individuals with T2DM may be concordant (conditions that overlap with T2DM in their pathogenesis and management plans such as cardiovascular diseases) or discordant (conditions with unrelated pathogenesis or management plans such as musculoskeletal disorders) or dominant (conditions whose severity eclipses all other illness management plans such as metastatic cancer). There is documented evidence on the negative consequences of depression in adults with T2DM. However, there is only limited knowledge on how the types of …

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Identification Of A Critical Gene In The Dihydroergot Alkaloid Pathway, Yulia Bilovol Jan 2015

Identification Of A Critical Gene In The Dihydroergot Alkaloid Pathway, Yulia Bilovol

Graduate Theses, Dissertations, and Problem Reports (ETD)

Ergot alkaloids, bioactive compounds produced by some species of fungi, have had significant impacts on agriculture and medicine. Claviceps purpurea and Epichloe spp. are ergot alkaloid producers associated with agricultural commodities and negatively affect humans and grazing animals, respectively. Another ergot alkaloid-producing fungus called Aspergillus fumigatus is ubiquitous in the environment; infections arising after inhaling the spores may kill immunocompromised persons. Ergot alkaloids and their derivatives are utilized by the pharmaceutical industry for the development of drugs. Some of these drugs are derived from lysergic acid, whereas others are derived from dihydrolysergic acid. Lysergic acid derivatives have vasoconstrictive properties and …

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Upscaling Of The Acidizing Process In Heterogeneous Porous Media, Vahidreza Bitarafhaghighi Jan 2015

Upscaling Of The Acidizing Process In Heterogeneous Porous Media, Vahidreza Bitarafhaghighi

Graduate Theses, Dissertations, and Problem Reports (ETD)

Coupled fluid flow, reaction and transport in porous media has been the topic of research in various disciplines for the past few decades. Conventional approach assumes a homogeneous and isotropic porous media, and simplifies the nature of coupling between fluid and rock interactions. However, including the reality of the process, i.e. assuming heterogeneous and anisotropic porous media with fully coupled rock fluid interaction, can lead to more advanced understanding of the fundamental physics behind the problem and developing efficient industrial applications. In the oil and gas industry optimization of different well stimulation techniques such as matrix acidizing in order to …

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Emotion Socialization And Autism Spectrum Disorder: The Role Of Disability Severity And Parental Attributions In Predicting Parents' Emotional Responses, Hilary R. Bougher Jan 2015

Emotion Socialization And Autism Spectrum Disorder: The Role Of Disability Severity And Parental Attributions In Predicting Parents' Emotional Responses, Hilary R. Bougher

Graduate Theses, Dissertations, and Problem Reports (ETD)

The importance of parents in emotion socialization is highly established among children who are typically developing (Sheffield Morris, Silk, Steinberg, Myers, & Robinson, 2007). Child characteristics, such as child temperament and emotional reactivity, have been found to influence parenting (Bell & Chapman, 1986; Belsky, 1984). However, little is known about the emotion socialization practices of parents of children with special needs and how disability severity may influence these practices. Participants included 68 parents of children with autism spectrum disorder (ASD) (ages 3-11). Parents reported on three dimensions, using three questionnaires: disability severity via the Vineland Adaptive Behavior Scales, 2nd edition …

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The Role Of Adenosine Monophosphate Activated Protein Kinase In Luteal Progesterone Production, Elizabeth Compton Bowdridge Jan 2015

The Role Of Adenosine Monophosphate Activated Protein Kinase In Luteal Progesterone Production, Elizabeth Compton Bowdridge

Graduate Theses, Dissertations, and Problem Reports (ETD)

Prostaglandin F2 alpha (PGF2&agr;) has in vivo luteolytic actions on the bovine corpus luteum (CL). Although PGF2&agr; is utilized extensively in livestock to synchronize estrus, its actions in vitro are controversial and do not always result in a reduction in progesterone (P4) secretion. The mechanism of action of PGF2&agr; is thought to involve activation of the phospholipase C-Ca2+ pathway. The luteolytic actions of PGF2&agr; are mediated through an elevation of cytosolic Ca2+ involving activation of protein kinase C (PKC). Expression of PKC isozymes and calcium/calmodulin-dependent protein kinase kinase 2 (CAMKK2) change as the CL develops to a mature stage. Either …

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Use Of Protein Immobilization To Measure Cytochrome P450 Conduction And Metabolism Kinetics, Christopher D. Bostick Jan 2015

Use Of Protein Immobilization To Measure Cytochrome P450 Conduction And Metabolism Kinetics, Christopher D. Bostick

Graduate Theses, Dissertations, and Problem Reports (ETD)

Cytochrome P450s (P450s) are a large family (>11,000) of heme thiolated proteins that are responsible for ~ 75% of the metabolism of pharmaceuticals on the market. Understanding P450 mediated metabolism is crucial for accurate in vitro predictions of drug metabolism. P450 protein-protein interactions have been shown to alter enzyme catalytic activity. Furthermore, these interactions are isoform specific, and can elicit activation, inhibition, or no effect on enzymatic activity. Studies show these effects are also dependent on the protein binding partner cytochrome P450 reductase (CPR), and the order of protein addition to purified reconstituted enzyme systems. In the current work, …

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