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The Myths Of Data Exclusivity, Erika Lietzan Jan 2016

The Myths Of Data Exclusivity, Erika Lietzan

Faculty Publications

This article contributes to an ongoing academic and public policy dialogue over whether and on what terms U.S. law should provide “data exclusivity” for new medicines. Five years after a new drug has been approved on the basis of an extensive application that may have cost more than one billion dollars to generate, federal law permits submission of a much smaller application to market a duplicate version of the drug. This second application is a different type of application, and it may cost no more than a few million dollars to prepare. A similar sequence is true for biological medicines: …

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The Law Of 180-Day Exclusivity, Erika Lietzan, Julia Post Jan 2016

The Law Of 180-Day Exclusivity, Erika Lietzan, Julia Post

Faculty Publications

In 1984, Congress created a statutory pathway for approval of generic drug applications and included an incentive for generic applicants to challenge the patents claiming the reference drugs on which they based their applications. The first generic applicant to file an ANDA with a patent challenge is eligible for 180 days of generic market exclusivity. This article is the fourth in a series of articles describing the resulting body of law, as interpreted and applied by FDA (in regulations, guidances, citizen petition responses, and individual decisions awarding and denying exclusivity) and the courts. The heart of the article is section …

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International Intellectual Property Shelters, Sam F. Halabi Jan 2016

International Intellectual Property Shelters, Sam F. Halabi

Faculty Publications

The battle over the reach and strength of international protections for intellectual property rights is one of the critical flashpoints between wealthy and low-income countries: those protections are perceived to obstruct access to essential medicines, thwart regulatory efforts to promote individual and population health, and undermine traditional forms of agriculture and food production. While scholars have thoroughly tracked the bilateral and multilateral trade and investment treaties responsible for the expansion of international intellectual property rights worldwide, they have paid significantly less attention to the strength and form that opposition to international intellectual property expansion has taken. This Article examines the …

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A Review Of Radiotherapy-Induced Late Effects Research After Advanced Technology Treatments, Wayne D. Newhauser, Amy Berrington De Gonzalez, Reinhard Schulte, Choonsik Lee Jan 2016

A Review Of Radiotherapy-Induced Late Effects Research After Advanced Technology Treatments, Wayne D. Newhauser, Amy Berrington De Gonzalez, Reinhard Schulte, Choonsik Lee

Faculty Publications

The number of incident cancers and long-term cancer survivors is expected to increase substantially for at least a decade. Advanced technology radiotherapies, e.g., using beams of protons and photons, offer dosimetric advantages that theoretically yield better outcomes. In general, evidence from controlled clinical trials and epidemiology studies are lacking. To conduct these studies, new research methods and infrastructure will be needed. In the paper, we review several key research methods of relevance to late effects after advanced technology proton-beam and photon-beam radiotherapies. In particular, we focus on the determination of exposures to therapeutic and stray radiation and related uncertainties, with …

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Solid-State Nmr Investigations Of Cellulose Structure And Interactions With Matrix Polysaccharides In Plant Primary Cell Walls, Tuo Wang, Mei Hong Jan 2016

Solid-State Nmr Investigations Of Cellulose Structure And Interactions With Matrix Polysaccharides In Plant Primary Cell Walls, Tuo Wang, Mei Hong

Faculty Publications

© The Author 2015. Published by Oxford University Press on behalf of the Society for Experimental Biology. Until recently, the 3D architecture of plant cell walls was poorly understood due to the lack of high-resolution techniques for characterizing the molecular structure, dynamics, and intermolecular interactions of the wall polysaccharides in these insoluble biomolecular mixtures. We introduced multidimensional solid-state NMR (SSNMR) spectroscopy, coupled with 13C labelling of whole plants, to determine the spatial arrangements of macromolecules in near-native plant cell walls. Here we review key evidence from 2D and 3D correlation NMR spectra that show relatively few cellulose-hemicellulose cross peaks but …

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Peptidines: Glycine-Amidine-Based Oligomers For Solution- And Solid-Phase Synthesis, Julian Vastl, Rendy Kartika, Kichul Park, Art E. Cho, David A. Spiegel Jan 2016

Peptidines: Glycine-Amidine-Based Oligomers For Solution- And Solid-Phase Synthesis, Julian Vastl, Rendy Kartika, Kichul Park, Art E. Cho, David A. Spiegel

Faculty Publications

© The Royal Society of Chemistry 2016. Efforts to emulate biological oligomers have given rise to a host of useful technologies, ranging from solid-phase peptide and nucleic acid synthesis to various peptidomimetic platforms. Herein we introduce a novel class of peptide-like oligomers called "peptidines" wherein each carbonyl O-atom within poly-N-alkyl glycine oligomers is replaced with a functionalized N-atom. Compared to peptoids or peptides, the presence of this amidine N-substituent in peptidines effectively doubles the number of diversification sites per monomeric unit, and can decrease their overall conformational flexibility. We have developed iterative solution- and solid-phase protocols for the straightforward assembly …

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Tip Enhanced Laser Ablation Sample Transfer For Mass Spectrometry, Kermit K. Murray, Suman Ghorai, Chinthaka A. Seneviratne Jan 2016

Tip Enhanced Laser Ablation Sample Transfer For Mass Spectrometry, Kermit K. Murray, Suman Ghorai, Chinthaka A. Seneviratne

Faculty Publications

© 2015 Materials Research Society. Mass spectrometry is one of the primary analysis techniques for biological analysis but there are technological barriers in sampling scale that must be overcome for it to be used to its full potential on the size scale of single cells. Current mass spectrometry imaging methods are limited in spatial resolution when analyzing large biomolecules. The goal of this project is to use atomic force microscope (AFM) tip enhanced laser ablation to remove material from cells and tissue and capture it for subsequent mass spectrometry analysis. The laser ablation sample transfer system uses an AFM stage …

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Ionic Liquid Crosslinkers For Chiral Imprinted Nanogumbos, Suzana Hamdan, Leonard Moore, Jason Lejeune, Farhana Hasan, Trevor K. Carlisle, Jason E. Bara, D. L. Gin, Andrew L. Lafrate, R. D. Noble, David A. Spivak, Isiah M. Warner Jan 2016

Ionic Liquid Crosslinkers For Chiral Imprinted Nanogumbos, Suzana Hamdan, Leonard Moore, Jason Lejeune, Farhana Hasan, Trevor K. Carlisle, Jason E. Bara, D. L. Gin, Andrew L. Lafrate, R. D. Noble, David A. Spivak, Isiah M. Warner

Faculty Publications

© 2015 Elsevier Inc. Molecularly imprinted polymers (MIPs) are an important class of selective materials for molecular specific sensors and separations. Molecular imprinting using non-covalent interactions in aqueous conditions still remains a difficult challenge due to interruption of hydrogen-bonding or electrostatic interactions water. Newly developed crosslinking ionic liquids are demonstrated herein to overcome problems of synthesizing aqueous MIPs, adding to previous examples of ionic liquids used as monomers in non-aqueous conditions or used as MIP solvents. Vinylimidazole ionic liquid crosslinkers were synthesized and subsequently explored as matrix supports for fabrication of molecularly imprinted polymeric nanoGUMBOS (nanoparticles derived from a group …

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Helicopter-Borne Transient Electromagnetics In High-Latitude Environments: An Application In The Mcmurdo Dry Valleys, Antarctica, Neil Foley, Slawek Tulaczyk, Esben Auken, Cyril Schamper, Hilary Dugan, Jill Mikucki, Ross Virginia, Peter Doran Jan 2016

Helicopter-Borne Transient Electromagnetics In High-Latitude Environments: An Application In The Mcmurdo Dry Valleys, Antarctica, Neil Foley, Slawek Tulaczyk, Esben Auken, Cyril Schamper, Hilary Dugan, Jill Mikucki, Ross Virginia, Peter Doran

Faculty Publications

© 2015 Society of Exploration Geophysicists. The McMurdo Dry Valleys are a polar desert in coastal Antarctica, where glaciers, permafrost, ice-covered lakes, and ephemeral summer streams coexist. Liquid water is found at the surface only in lakes and in the temporary streams that feed them. Past geophysical exploration has yielded ambiguous results regarding the presence of subsurface water. In 2011, we used a helicopterborne, time-domain electromagnetic (TDEM) sensor to map resistivity in the subsurface across the Dry Valleys. The airborne electromagnetic (AEM) method excels at finding subsurface liquid water in polar deserts, where water remains liquid under cold conditions if …

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Comparison Of Electrophysiological Auditory Measures In Fishes, Karen P. Maruska, Joseph A. Sisneros Jan 2016

Comparison Of Electrophysiological Auditory Measures In Fishes, Karen P. Maruska, Joseph A. Sisneros

Faculty Publications

© Springer International Publishing Switzerland 2016. Sounds provide fishes with important information used to mediate behaviors such as predator avoidance, prey detection, and social communication. How we measure auditory capabilities in fishes, therefore, has crucial implications for interpreting how individual species use acoustic information in their natural habitat. Recent analyses have highlighted differences between behavioral and electrophysiologically determined hearing thresholds, but less is known about how physiological measures at different auditory processing levels compare within a single species. Here we provide one of the first comparisons of auditory threshold curves determined by different recording methods in a single fish species, …

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A Member Of The Phosphate Transporter 1 (Pht1) Family From The Arsenic-Hyperaccumulating Fern Pteris Vittata Is A High-Affinity Arsenate Transporter, Sandra Feuer Ditusa, Elena B. Fontenot, Robert W. Wallace, Molly A. Silvers, Thomas N. Steele, Alia H. Elnagar, Kelsey M. Dearman, Aaron P. Smith Jan 2016

A Member Of The Phosphate Transporter 1 (Pht1) Family From The Arsenic-Hyperaccumulating Fern Pteris Vittata Is A High-Affinity Arsenate Transporter, Sandra Feuer Ditusa, Elena B. Fontenot, Robert W. Wallace, Molly A. Silvers, Thomas N. Steele, Alia H. Elnagar, Kelsey M. Dearman, Aaron P. Smith

Faculty Publications

© 2015 New Phytologist Trust. Pteris vittata exhibits enhanced arsenic uptake, but the corresponding mechanisms are not well known. The prevalent form of arsenic in most soils is arsenate, which is a phosphate analog and a substrate for Phosphate transporter 1 (Pht1) transporters. Herein we identify and characterize three P. vittata Pht1 transporters. Pteris vittata Pht1 cDNAs were isolated and characterized via heterologous expression in Saccharomyces cerevisiae (yeast) and Nicotiana benthamiana leaves. Expression of the PvPht1 loci in P. vittata gametophytes was also examined in response to phosphate deficiency and arsenate exposure. Expression of each of the PvPht1 cDNAs complemented …

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Coloration In The Polymorphic Frog Oophaga Pumilio Associates With Level Of Aggressiveness In Intraspecific And Interspecific Behavioral Interactions, Sandra P. Galeano, Kyle E. Harms Jan 2016

Coloration In The Polymorphic Frog Oophaga Pumilio Associates With Level Of Aggressiveness In Intraspecific And Interspecific Behavioral Interactions, Sandra P. Galeano, Kyle E. Harms

Faculty Publications

© 2015, Springer-Verlag Berlin Heidelberg. Intraspecific morphological variation may correspond to behavioral variation that helps determine the nature of species interactions. Color variation among populations of variably toxic organisms has been shown to associate with alternative anti-predator behaviors. However, the effects of these alternative behavioral tendencies on the outcomes of interspecific interactions other than predator–prey remain largely unexplored. We investigated how coloration and body size variation in Oophaga pumilio, one of the most phenotypically diverse amphibians known, associated with territorial aggressiveness and how this association influenced the outcome of agonistic male–male interactions with conspecifics and heterospecifics of two sympatric species …

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Liposomes With Diverse Compositions Are Protected During Desiccation By Lea Proteins From Artemia Franciscana And Trehalose, Daniel S. Moore, Richard Hansen, Steven C. Hand Jan 2016

Liposomes With Diverse Compositions Are Protected During Desiccation By Lea Proteins From Artemia Franciscana And Trehalose, Daniel S. Moore, Richard Hansen, Steven C. Hand

Faculty Publications

© 2015 Published by Elsevier B.V. Intracellular accumulation of Late Embryogenesis Abundant (LEA) proteins and the disaccharide trehalose is associated with cellular desiccation tolerance in a number of animal species. Two LEA proteins from anhydrobiotic embryos of the brine shrimp Artemia franciscana were tested for the ability to protect liposomes of various compositions against desiccation-induced damage in the presence and absence of trehalose. Damage was assessed by carboxyfluorescein leakage after drying and rehydration. Further, using a cytoplasmic-localized (AfrLEA2) and a mitochondrial-targeted (AfrLEA3m) LEA protein allowed us to evaluate whether each may preferentially stabilize membranes of a particular lipid composition based …

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Isolation And Characterization Of Extremely Halophilic Co-Oxidizing Euryarchaeota From Hypersaline Cinders, Sediments And Soils And Description Of A Novel Co Oxidizer, Haloferax Namakaokahaiae Mke2.3T, Sp. Nov., S. Mcduff, G. M. King, S. Neupane, M. R. Myers Jan 2016

Isolation And Characterization Of Extremely Halophilic Co-Oxidizing Euryarchaeota From Hypersaline Cinders, Sediments And Soils And Description Of A Novel Co Oxidizer, Haloferax Namakaokahaiae Mke2.3T, Sp. Nov., S. Mcduff, G. M. King, S. Neupane, M. R. Myers

Faculty Publications

© FEMS 2016. All rights reserved. phylogenetic affiliations of organisms responsible for aerobic CO oxidation in hypersaline soils and sediments were assessed using media containing 3.8 M NaCl. CO-oxidizing strains of the euryarchaeotes, Haloarcula, Halorubrum, Haloterrigena and Natronorubrum, were isolated from the Bonneville Salt Flats (UT) and Atacama Desert salterns (Chile). A halophilic euryarchaeote, Haloferax strain Mke2.3T, was isolated from Hawai'i Island saline cinders. Haloferax strain Mke2.3T was most closely related to Haloferax larsenii JCM 13917T (97.0% 16S rRNA sequence identity). It grew with a limited range of substrates, and oxidized CO at a headspace concentration of 0.1%. However, it …

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Two New Species Of Siphocampylus (Campanulaceae, Lobelioideae) From The Central Andes, Laura P. Lagomarsino, Daniel Santamaría-Aguilar Jan 2016

Two New Species Of Siphocampylus (Campanulaceae, Lobelioideae) From The Central Andes, Laura P. Lagomarsino, Daniel Santamaría-Aguilar

Faculty Publications

© L.P. Lagomarsino, D. Santamaría-Aguilar. Two species of Siphocampylus (Campanulaceae: Lobelioideae) from the Central Andes of Peru and Bolivia are described, illustrated, and discussed with reference to related species. One species, Siphocampylus antonellii, is endemic to high elevation grasslands of Calca, Peru, while the second, S. siberiensis, is endemic to cloud forests of Cochabamba, Bolivia. Both species are robust shrubs that produce tubular pink flowers that are likely pollinated by hummingbirds.

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Autophagy Is Essential For Ultrafine Particle-Induced Inflammation And Mucus Hyperproduction In Airway Epithelium, Zhi Hua Chen, Yin Fang Wu, Ping Li Wang, Yan Ping Wu, Zhou Yang Li, Yun Zhao, Jie Sen Zhou, Chen Zhu, Chao Cao, Yuan Yuan Mao, Feng Xu, Bei Bei Wang, Stephania A. Cormier, Song Min Ying, Wen Li, Hua Hao Shen Jan 2016

Autophagy Is Essential For Ultrafine Particle-Induced Inflammation And Mucus Hyperproduction In Airway Epithelium, Zhi Hua Chen, Yin Fang Wu, Ping Li Wang, Yan Ping Wu, Zhou Yang Li, Yun Zhao, Jie Sen Zhou, Chen Zhu, Chao Cao, Yuan Yuan Mao, Feng Xu, Bei Bei Wang, Stephania A. Cormier, Song Min Ying, Wen Li, Hua Hao Shen

Faculty Publications

© 2016 Taylor & Francis Group, LLC. Environmental ultrafine particulate matter (PM) is capable of inducing airway injury, while the detailed molecular mechanisms remain largely unclear. Here, we demonstrate pivotal roles of autophagy in regulation of inflammation and mucus hyperproduction induced by PM containing environmentally persistent free radicals in human bronchial epithelial (HBE) cells and in mouse airways. PM was endocytosed by HBE cells and simultaneously triggered autophagosomes, which then engulfed the invading particles to form amphisomes and subsequent autolysosomes. Genetic blockage of autophagy markedly reduced PM-induced expression of inflammatory cytokines, e.g. IL8 and IL6, and MUC5AC in HBE cells. …

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Plastic And Evolved Responses To Global Change: What Can We Learn From Comparative Transcriptomics?, Melissa B. Debiasse, Morgan W. Kelly Jan 2016

Plastic And Evolved Responses To Global Change: What Can We Learn From Comparative Transcriptomics?, Melissa B. Debiasse, Morgan W. Kelly

Faculty Publications

© The American Genetic Association. 2015. All rights reserved. Physiological plasticity and adaptive evolution may facilitate persistence in a changing environment. As a result, there is an interest in understanding species' capacities for plastic and evolved responses, and the mechanisms by which these responses occur. Transcriptome sequencing has become a powerful tool for addressing these questions, providing insight into otherwise unobserved effects of changing conditions on organismal physiology and variation in these effects among individuals and populations. Here, we review recent studies using comparative transcriptomics to understand plastic and evolutionary responses to changing environments. We focus on 2 areas where …

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Herpes Simplex Virus 1 Ul37 Protein Tyrosine Residues Conserved Among All Alphaherpesviruses Are Required For Interactions With Glycoprotein K, Cytoplasmic Virion Envelopment, And Infectious Virus Production, Dmitry V. Chouljenko, Nithya Jambunathan, Vladimir N. Chouljenko, Misagh Naderi, Michal Brylinski, John R. Caskey, Konstantin G. Kousoulas Jan 2016

Herpes Simplex Virus 1 Ul37 Protein Tyrosine Residues Conserved Among All Alphaherpesviruses Are Required For Interactions With Glycoprotein K, Cytoplasmic Virion Envelopment, And Infectious Virus Production, Dmitry V. Chouljenko, Nithya Jambunathan, Vladimir N. Chouljenko, Misagh Naderi, Michal Brylinski, John R. Caskey, Konstantin G. Kousoulas

Faculty Publications

© 2016, American Society for Microbiology. All Rights Reserved. The herpes simplex virus 1 (HSV-1) UL37 protein functions in virion envelopment at trans-Golgi membranes, as well as in retrograde and anterograde transport of virion capsids. Recently, we reported that UL37 interacts with glycoprotein K (gK) and its interacting partner protein UL20 (N. Jambunathan, D. Chouljenko, P. Desai, A. S. Charles, R. Subramanian, V. N. Chouljenko, and K. G. Kousoulas, J Virol 88:5927-5935, 2014, http://dx.doi.org/10.1128/JVI.00278-14), facilitating cytoplasmic virion envelopment. Alignment of UL37 homologs encoded by alphaherpesviruses revealed the presence of highly conserved residues in the central portion of the UL37 protein. …

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Biological Control Activities Of Rice-Associated Bacillus Sp. Strains Against Sheath Blight And Bacterial Panicle Blight Of Rice, Bishnu K. Shrestha, Hari Sharan Karki, Donald E. Groth, Nootjarin Jungkhun, Jong Hyun Ham Jan 2016

Biological Control Activities Of Rice-Associated Bacillus Sp. Strains Against Sheath Blight And Bacterial Panicle Blight Of Rice, Bishnu K. Shrestha, Hari Sharan Karki, Donald E. Groth, Nootjarin Jungkhun, Jong Hyun Ham

Faculty Publications

Potential biological control agents for two major rice diseases, sheath blight and bacterial panicle blight, were isolated from rice plants in this study. Rice-associated bacteria (RABs) isolated from rice plants grown in the field were tested for their antagonistic activities against the rice pathogens, Rhizoctonia solani and Burkholderia glumae, which cause sheath blight and bacterial panicle blight, respectively. Twenty-nine RABs were initially screened based on their antagonistic activities against both R. solani and B. glumae. In follow-up retests, 26 RABs of the 29 RABs were confirmed to have antimicrobial activities, but the rest three RABs did not reproduce any observable …

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Association Of Polymorphisms In The Aldosterone-Regulated Sodium Reabsorption Pathway With Blood Pressure Among Hispanics, Bamidele O. Tayo, Liping Tong, Richard S. Cooper Jan 2016

Association Of Polymorphisms In The Aldosterone-Regulated Sodium Reabsorption Pathway With Blood Pressure Among Hispanics, Bamidele O. Tayo, Liping Tong, Richard S. Cooper

Faculty Publications

Background: Whereas genome-wide association study (GWAS) has proven to be an important tool for discovery of variants influencing many human diseases and traits, unfortunately its performance has not been much of all-around success for some complex conditions, for example, hypertension. Because some of the existing effective pharmacotherapeutic agents act by targeting known biological pathways, pathway-based analytical approaches could lead to more success in discovery of disease-associated variants. The objective of the present study was to identify functional variants associated with blood pressure in the aldosterone-regulated sodium reabsorption pathway using the simulated and real blood pressure phenotypes provided for Genetic Analysis …

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Pteridine Levels And Head Weights Are Correlated With Age And Colony Task In The Honey Bee, Apis Mellifera, Frank D. Rinkevich, Joseph W. Margotta, Jean M. Pittman, James A. Ottea, Kristen B. Healy Jan 2016

Pteridine Levels And Head Weights Are Correlated With Age And Colony Task In The Honey Bee, Apis Mellifera, Frank D. Rinkevich, Joseph W. Margotta, Jean M. Pittman, James A. Ottea, Kristen B. Healy

Faculty Publications

Background. The age of an insect strongly influences many aspects of behavior and reproduction. The interaction of age and behavior is epitomized in the temporal polyethism of honey bees in which young adult bees perform nurse and maintenance duties within the colony, while older bees forage for nectar and pollen. Task transition is dynamic and driven by colony needs. However, an abundance of precocious foragers or overage nurses may have detrimental effects on the colony. Additionally, honey bee age affects insecticide sensitivity. Therefore, determining the age of a set of individual honey bees would be an important measurement of colony …

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Cognitive Phenotypes And The Evolution Of Animal Decisions, Tamra C. Mendelson, Courtney L. Fitzpatrick, Mark E. Hauber, Charles H. Pence, Rafael L. Rodríguez, Rebecca J. Safran, Caitlin A. Stern, Jeffrey R. Stevens Jan 2016

Cognitive Phenotypes And The Evolution Of Animal Decisions, Tamra C. Mendelson, Courtney L. Fitzpatrick, Mark E. Hauber, Charles H. Pence, Rafael L. Rodríguez, Rebecca J. Safran, Caitlin A. Stern, Jeffrey R. Stevens

Faculty Publications

Despite the clear fitness consequences of animal decisions, the science of animal decision making in evolutionary biology is underdeveloped compared with decision science in human psychology. Specifically, the field lacks a conceptual framework that defines and describes the relevant components of a decision, leading to imprecise language and concepts. The ‘judgment and decision-making’ (JDM) framework in human psychology is a powerful tool for framing and understanding human decisions, and we apply it here to components of animal decisions, which we refer to as ‘cognitive phenotypes’. We distinguish multiple cognitive phenotypes in the context of a JDM framework and highlight empirical …

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Concept, Conversion, Cultivation, And Consequence: The Four Cs Of Successful Collaboration, Sarah Simms, Hayley Johnson Jan 2016

Concept, Conversion, Cultivation, And Consequence: The Four Cs Of Successful Collaboration, Sarah Simms, Hayley Johnson

Faculty Publications

In an effort to change the librarian-faculty collaboration culture at Nicholls State University, librarians actively sought grant opportunities to make resources available to the university which would facilitate collaboration. Nicholls was able to secure grant funding for a collaborative multidisciplinary research workshop series to promote undergraduate research. The objective of this grant funded opportunity was to place the library in a central role in the enhancement and expansion of the university’s research initiatives and partner with those disciplines that were traditionally self-contained. The technology and training made available to students through this initiative is important as it provides all students …

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Acetylation Of Androgen Receptor By Ard1 Promotes Dissociation From Hsp90 Complex And Prostate Tumorigenesis, John S. Depaolo, Zehua Wang, Jianhui Guo, Guanyi Zhang, Chiping Qian, Haitao Zhang, Jovanny Zabaleta, Wanguo Liu Jan 2016

Acetylation Of Androgen Receptor By Ard1 Promotes Dissociation From Hsp90 Complex And Prostate Tumorigenesis, John S. Depaolo, Zehua Wang, Jianhui Guo, Guanyi Zhang, Chiping Qian, Haitao Zhang, Jovanny Zabaleta, Wanguo Liu

Faculty Publications

Prostate cancer is an androgen receptor (AR)-driven disease and post-translational modification of AR is critical for AR activation. We previously reported that Arrestdefective protein 1 (ARD1) is an oncoprotein in prostate cancer. It acetylates and activates AR to promote prostate tumorigenesis. However, the ARD1-targeted residue within AR and the mechanisms of the acetylation event in prostate tumorigenesis remained unknown. In this study, we show that ARD1 acetylates AR at lysine 618 (K618) in vitro and in vivo. An AR construct with the charged lysine substitution by arginine (AR-618R) reduces RNA Pol II binding, AR transcriptional activity, prostate cancer cell growth, …

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Rearrangement And Evolution Of Mitochondrial Genomes In Parrots, Jessica R. Eberhard, Timothy F. Wright Jan 2016

Rearrangement And Evolution Of Mitochondrial Genomes In Parrots, Jessica R. Eberhard, Timothy F. Wright

Faculty Publications

© 2015 Elsevier Inc. Mitochondrial genome rearrangements that result in control region duplication have been described for a variety of birds, but the mechanisms leading to their appearance and maintenance remain unclear, and their effect on sequence evolution has not been explored. A recent survey of mitochondrial genomes in the Psittaciformes (parrots) found that control region duplications have arisen independently at least six times across the order. We analyzed complete mitochondrial genome sequences from 20 parrot species, including representatives of each lineage with control region duplications, to document the gene order changes and to examine effects of genome rearrangements on …

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Formation Of Environmentally Persistent Free Radical (Epfr) In Iron(Iii) Cation-Exchanged Smectite Clay, Ugwumsinachi G. Nwosu, Amitava Roy, Albert Leo N. Dela Cruz, Barry Dellinger, Robert Cook Jan 2016

Formation Of Environmentally Persistent Free Radical (Epfr) In Iron(Iii) Cation-Exchanged Smectite Clay, Ugwumsinachi G. Nwosu, Amitava Roy, Albert Leo N. Dela Cruz, Barry Dellinger, Robert Cook

Faculty Publications

Environmentally persistent free radicals (EPFRs) have been found at a number of Superfund sites, with EPFRs being formed via a proposed redox process at ambient environmental conditions. The possibility of such a redox process taking place at ambient environmental conditions is studied utilizing a surrogate soil system of phenol and iron(iii)-exchanged calcium montmorillonite clay, Fe(iii)CaM. Sorption of phenol by the Fe(iii)CaM is demonstrated by Fourier-transformed infra-red (FT-IR) spectroscopy, as evidenced by the peaks between 1345 cm and 1595 cm , and at lower frequencies between 694 cm and 806 cm , as well as X-ray diffraction (XRD) spectroscopy, as shown …

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Formation Of Environmentally Persistent Free Radical (Epfr) In Iron(Iii) Cation-Exchanged Smectite Clay, Ugwumsinachi G. Nwosu, Amitava Roy, Albert Leo N. Dela Cruz, Barry Dellinger, Robert Cook Jan 2016

Formation Of Environmentally Persistent Free Radical (Epfr) In Iron(Iii) Cation-Exchanged Smectite Clay, Ugwumsinachi G. Nwosu, Amitava Roy, Albert Leo N. Dela Cruz, Barry Dellinger, Robert Cook

Faculty Publications

Environmentally persistent free radicals (EPFRs) have been found at a number of Superfund sites, with EPFRs being formed via a proposed redox process at ambient environmental conditions. The possibility of such a redox process taking place at ambient environmental conditions is studied utilizing a surrogate soil system of phenol and iron(iii)-exchanged calcium montmorillonite clay, Fe(iii)CaM. Sorption of phenol by the Fe(iii)CaM is demonstrated by Fourier-transformed infra-red (FT-IR) spectroscopy, as evidenced by the peaks between 1345 cm and 1595 cm , and at lower frequencies between 694 cm and 806 cm , as well as X-ray diffraction (XRD) spectroscopy, as shown …

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Cryopreservation In Fish: Current Status And Pathways To Quality Assurance And Quality Control In Repository Development, Leticia Torres, E. Hu, Terrence R. Tiersch Jan 2016

Cryopreservation In Fish: Current Status And Pathways To Quality Assurance And Quality Control In Repository Development, Leticia Torres, E. Hu, Terrence R. Tiersch

Faculty Publications

Cryopreservation in aquatic species in general has been constrained to research activities for more than 60 years. Although the need for application and commercialisation pathways has become clear, the lack of comprehensive quality assurance and quality control programs has impeded the progress of the field, delaying the establishment of germplasm repositories and commercial-scale applications. In this review we focus on the opportunities for standardisation in the practices involved in the four main stages of the cryopreservation process: (1) source, housing and conditioning of fish; (2) sample collection and preparation; (3) freezing and cryogenic storage of samples; and (4) egg collection …

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A Deterministic Model For Predicting Hourly Dissolved Oxygen Change: Development And Application To A Shallow Eutrophic Lake, Zhen Xu, Y. Jun Xu Jan 2016

A Deterministic Model For Predicting Hourly Dissolved Oxygen Change: Development And Application To A Shallow Eutrophic Lake, Zhen Xu, Y. Jun Xu

Faculty Publications

Predicting dissolved oxygen (DO) change at a high frequency in water bodies is useful for water quality management. In this study, we developed a deterministic model that can predict hourly DO change in a water body with high frequency weather parameters. The study was conducted during August 2008-July 2009 in a eutrophic shallow lake in Louisiana, USA. An environment monitoring buoy was deployed to record DO, water temperature and chlorophyll-a concentration at 15-min intervals, and hourly weather data including air temperature, precipitation, wind speed, relative humidity, and solar radiation were gathered from a nearby weather station. These data formed a …

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Glufosinate Rate And Timing For Control Of Glyphosate-Resistant Rhizomatous Johnsongrass (Sorghum Halepense) In Glufosinate-Resistant Soybean, Randall L. Landry, Daniel O. Stephenson, Brandi C. Woolam Jan 2016

Glufosinate Rate And Timing For Control Of Glyphosate-Resistant Rhizomatous Johnsongrass (Sorghum Halepense) In Glufosinate-Resistant Soybean, Randall L. Landry, Daniel O. Stephenson, Brandi C. Woolam

Faculty Publications

Field studies were conducted over a three-year period (2011, 2012, and 2013) in Louisiana to evaluate the effect of glufosinate rate and timing on glyphosate-resistant (GR) rhizomatous johnsongrass control in glufosinate-resistant soybean. Treatments included glufosinate (0.5, 0.6, or 0.7 kg ai ha-1) applied alone POST1 (46 cm tall johnsongrass) and sequentially 3 (POST2) or 4 (POST3) wk after POST1 at 0.5 or 0.6 kg ha-1. Glufosinate (0.7 kg ha-1) applied POST1 controlled johnsongrass 77% at soybean harvest. Averaged across sequential application rate, delaying the sequential application from POST2 to POST3 increased control from 65 to 78% at harvest. Increasing sequential …

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