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Spatial Distribution Of Earthworms In An East Texas Forest Ecosystem, Melissa A. Bozarth, Kenneth W. Farrish, George A. Damoff, James Van Kley, J. Leon Young Jan 2016

Spatial Distribution Of Earthworms In An East Texas Forest Ecosystem, Melissa A. Bozarth, Kenneth W. Farrish, George A. Damoff, James Van Kley, J. Leon Young

Faculty Publications

Earthworms were collected and identified in different ecological habitats of the Stephen F. Austin Experimental Forest (SFAEF) in the Piney Woods Ecoregion (PWE) of Texas. Earthworm spatial distribution data were collected over four distinct ecological habitats with a range of soil conditions and vegetative cover. A total of 128 sampling plots were surveyed in two different, broadly defined locations (mesic slope = 68 plots, dry-mesic upland = 60 plots). Using multivariate classification/ordination (TWINSPAN) and detrended correspondence analysis (DCA) of overstory vegetation data, these two locations were further divided into four distinct habitats: dry-mesic mixed upland, transitional zone, mesic slope and …

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Androgyny/Hermaphroditism: Hebrew Bible, Jennifer J. Williams Jan 2016

Androgyny/Hermaphroditism: Hebrew Bible, Jennifer J. Williams

Faculty Publications

The Hebrew Bible lacks a term for androgyny or hermaphroditism. The term tumtumim, which identifies persons of indeterminate or “hidden” sex, appears later in rabbinic texts. Nevertheless, sexual fluidity, ambiguity, intersexed persons, and persons with a combination of masculine and feminine characteristics appear in the Genesis creation stories and prophetic texts. While gender transgression is relevant to the general discussion, this entry from The Oxford Encyclopedia of the Bible and Gender Studies: Oxford Biblical Studies Online focuses primarily on ancient understandings, namely those presented in the Hebrew Bible, of those of “both sexes.”

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Effects Of The Deepwater Horizon Oil Spill On Coastal Marshes And Associated Organisms, N N. Rabalais, R. Eugene Turner Jan 2016

Effects Of The Deepwater Horizon Oil Spill On Coastal Marshes And Associated Organisms, N N. Rabalais, R. Eugene Turner

Faculty Publications

Oil gushed from the Macondo Mississippi Canyon 252 well into the Gulf of Mexico for 87 days after the Deepwater Horizon drilling rig exploded and sank. A concern, after widespread dispersant use offshore on surface waters and at the wellhead, was that the oil/dispersant mixture would reach valuable, and vulnerable, coastal ecosystems. Standardized oil spill response methodology identified 1,773 km of the 7,058 km of surveyed shoreline as oiled, with 1,075 km oiled in Louisiana. This paper synthesizes key results of published research on the oiling effects on coastal habitats and their inhabitants from microbes to vertebrates. There were immediate …

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Islands In The Oil: Quantifying Salt Marsh Shoreline Erosion After The Deepwater Horizon Oiling, R. Eugene Turner, G Mcclenachan, A W. Tweel Jan 2016

Islands In The Oil: Quantifying Salt Marsh Shoreline Erosion After The Deepwater Horizon Oiling, R. Eugene Turner, G Mcclenachan, A W. Tweel

Faculty Publications

Qualitative inferences and sparse bay-wide measurements suggest that shoreline erosion increased after the 2010 BP Deepwater Horizon (DWH) disaster, but quantifying the impacts has been elusive at the landscape scale. We quantified the shoreline erosion of 46 islands for before and after the DWH oil spill to determine how much shoreline was lost, if the losses were temporary, and if recovery/restoration occurred. The erosion rates at the oiled islands increased to 275% in the first six months after the oiling, were 200% of that of the unoiled islands for the first 2.5 years after the oiling, and twelve times the …

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Preface: Remote Sensing Of Water Resources, D.R. Mishra, E.J. D'Sa, S. Mishra Jan 2016

Preface: Remote Sensing Of Water Resources, D.R. Mishra, E.J. D'Sa, S. Mishra

Faculty Publications

No abstract provided.

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Seasonal Physiological Dynamics Of Maturing Female Southern Flounder (Paralichthys Lethostigma), Casey A. Grieshaber, Stephen R. Midway, Frederick S. Scharf, Heather Koopman, J. Adam Luckenbach, Mollie A. Middleton Jan 2016

Seasonal Physiological Dynamics Of Maturing Female Southern Flounder (Paralichthys Lethostigma), Casey A. Grieshaber, Stephen R. Midway, Frederick S. Scharf, Heather Koopman, J. Adam Luckenbach, Mollie A. Middleton

Faculty Publications

Physiological information is rarely used in descriptions of maturity for managed, wild fish species; however, the use of physiological data holds great promise to provide important detail on the complexities of oocyte development and maturity. Investigating southern flounder (Paralichthys lethostigma)—an overfished commercial and recreational fishery resource—we examined pre-spawn physiological changes in females to provide further detail of the maturation process. Given that adults of this species complete maturation and spawn in unknown offshore locations, information on pre-spawn physiological changes is particularly informative for both size- and age-based patterns of maturity. We evaluated seasonal and ontogenetic changes in hormone concentrations in …

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Coupled Oxygen And Dissolved Inorganic Carbon Dynamics In Coastal Ocean And Its Use As A Potential Indicator For Detecting Water Column Oil Degradation, X. Hu, W.-J. Cai, N.N. Rabalais, J. Xue Jan 2016

Coupled Oxygen And Dissolved Inorganic Carbon Dynamics In Coastal Ocean And Its Use As A Potential Indicator For Detecting Water Column Oil Degradation, X. Hu, W.-J. Cai, N.N. Rabalais, J. Xue

Faculty Publications

No abstract provided.

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Improving Treatment Of Neurodevelopmental Disorders: Recommendations Based On Preclinical Studies, Judith R. Homberg, Evan J. Kyzar, Adam Michael Stewart, Michael Nguyen, Manoj K. Poudel, David J. Ecchevaria, Adam D. Collier, Siddharth Gaikwad, Viktor M. Klimenko, William Norton, Julian Pittman, Shun Nakamura, Mamiko Koshiba, Hideo Yamanouchi, Sergey A. Apryatin, Maria Luisa Scattoni, David M. Diamond, Jeremy F.P. Ullmann, Matthew O. Parker, Richard E. Brown, Cai Song, Allan V. Kalueff Jan 2016

Improving Treatment Of Neurodevelopmental Disorders: Recommendations Based On Preclinical Studies, Judith R. Homberg, Evan J. Kyzar, Adam Michael Stewart, Michael Nguyen, Manoj K. Poudel, David J. Ecchevaria, Adam D. Collier, Siddharth Gaikwad, Viktor M. Klimenko, William Norton, Julian Pittman, Shun Nakamura, Mamiko Koshiba, Hideo Yamanouchi, Sergey A. Apryatin, Maria Luisa Scattoni, David M. Diamond, Jeremy F.P. Ullmann, Matthew O. Parker, Richard E. Brown, Cai Song, Allan V. Kalueff

Faculty Publications

Introduction: Neurodevelopmental disorders (NDDs) are common and severely debilitating. Their chronic nature and reliance on both genetic and environmental factors makes studying NDDs and their treatment a challenging task.Areas covered: Herein, the authors discuss the neurobiological mechanisms of NDDs, and present recommendations on their translational research and therapy, outlined by the International Stress and Behavior Society. Various drugs currently prescribed to treat NDDs also represent a highly diverse group. Acting on various neurotransmitter and physiological systems, these drugs often lack specificity of action, and are commonly used to treat multiple other psychiatric conditions. There has also been relatively little progress …

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Climate Change And The Confluence Of Natural And Human History: A Lawyer’S Perspective, Josh Eagle Jan 2016

Climate Change And The Confluence Of Natural And Human History: A Lawyer’S Perspective, Josh Eagle

Faculty Publications

No abstract provided.

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The Irrelevance Of Nanotechnology Patents, Emily M. Morris Jan 2016

The Irrelevance Of Nanotechnology Patents, Emily M. Morris

Faculty Publications

Although scientists have for decades now had the ability to manipulate matter at the atomic level, we have yet to see the nanotechnological revolution that these scientists predicted would follow. Despite the years of effort and billions of dollars that have been invested into research and development thus far, nanotechnology has yielded surprisingly few end-user applications. A number of commentators have blamed this lack of progress on the Bayh-Dole Act and other changes to patent law, arguing that, although these laws are supposed to stimulate technological development, they have in fact had the exact opposite effect when it comes to …

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Traditional Ecological Rulemaking, Anthony Moffa Jan 2016

Traditional Ecological Rulemaking, Anthony Moffa

Faculty Publications

This Article examines the implications of an increased role for Traditional Ecological Knowledge (TEK) in United States agency decisionmaking. Specifically, it contemplates where TEK might substantively and procedurally fit and, most importantly, whether a final agency action based on TEK would survive judicial scrutiny. In the midst of a growing body of scholarship questioning the wisdom of deference to agency expertise9 and the legitimacy of the administrative state writ large,10 this Article argues that there remains an important space in administrative rulemaking for the consideration of ways of understanding that differ from traditional Western norms. TEK can and should fill …

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Compelled Commercial Speech And The Consumer “Right To Know”, Jonathan H. Adler Jan 2016

Compelled Commercial Speech And The Consumer “Right To Know”, Jonathan H. Adler

Faculty Publications

Compelled commercial speech, including mandatory labeling and the disclosure of factually true information, should not be seen as a separate category of speech under the First Amendment. Rather, compelled commercial speech should be subject to the same level of protection as commercial speech generally. This means commercial speech compulsions, such as mandatory disclosures and labeling requirements, must be supported by a substantial government interest. The assertion of a consumer “right to know” does not constitute such an interest and cannot, by itself, justify compelled commercial speech. Allowing such a justification for compelled commercial speech would eviscerate any meaningful First Amendment …

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Synthesis, Characterization, And Biological Studies Of A Piperidinyl Appended Dipicolylamine Ligand And Its Rhenium Tricarbonyl Complex As Potential Therapeutic Agents For Human Breast Cancer, Amali Subasinghe, Inoka C. Perera, Svetlana Pakhomova, Theshini Perera Jan 2016

Synthesis, Characterization, And Biological Studies Of A Piperidinyl Appended Dipicolylamine Ligand And Its Rhenium Tricarbonyl Complex As Potential Therapeutic Agents For Human Breast Cancer, Amali Subasinghe, Inoka C. Perera, Svetlana Pakhomova, Theshini Perera

Faculty Publications

© 2016 Amali Subasinghe et al. A novel ligand bearing a central piperidinyl sulfonamide group, N(SO2pip)dpa, and its corresponding Re tricarbonyl complex, [Re(CO)3(N(SO2pip)dpa)]+, have been synthesized in good yield. The methylene CH2 signal seen as a singlet (4.54 ppm) in a 1H NMR spectrum of the ligand in DMSO-d6 appears as two doublets (5.39, 5.01 ppm) in a spectrum of the [Re(CO)3(N(SO2pip)dpa)]+ complex and confirms the presence of magnetically nonequivalent protons upon coordination to Re. Structural results revealed that the Re-N bond lengths fall within the normal range establishing coordination of ligand to metal. The presence of intraligand π→π and …

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Histidine Switch Controlling Ph-Dependent Protein Folding And Dna Binding In A Transcription Factor At The Core Of Synthetic Network Devices, D. K. Deochand, I. C. Perera, R. B. Crochet, N. C. Gilbert, M. E. Newcomer, A. Grove Jan 2016

Histidine Switch Controlling Ph-Dependent Protein Folding And Dna Binding In A Transcription Factor At The Core Of Synthetic Network Devices, D. K. Deochand, I. C. Perera, R. B. Crochet, N. C. Gilbert, M. E. Newcomer, A. Grove

Faculty Publications

© 2016 The Royal Society of Chemistry. Therapeutic strategies have been reported that depend on synthetic network devices in which a urate-sensing transcriptional regulator detects pathological levels of urate and triggers production or release of urate oxidase. The transcription factor involved, HucR, is a member of the multiple antibiotic resistance (MarR) protein family. We show that protonation of stacked histidine residues at the pivot point of long helices that form the scaffold of the dimer interface leads to reversible formation of a molten globule state and significantly attenuated DNA binding at physiological temperatures. We also show that binding of urate …

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Urban Microbiomes And Urban Agriculture: What Are The Connections And Why Should We Care?, Gary M. King Jan 2016

Urban Microbiomes And Urban Agriculture: What Are The Connections And Why Should We Care?, Gary M. King

Faculty Publications

© Springer Science+Business Media Dordrecht 2016. A large percentage (~50 %) of the global human population lives in urban systems. The transition from largely rural to urban lifestyles began gradually, but has accelerated. Given the magnitude of anthropogenic changes in the Earth system as a whole and concerns about resource availability and continued population growth, questions about the sustainability of urban systems have become a focal point for a variety of research and civic efforts, including programs promoting urban agriculture as a means to provide local food sources and to better manage critical nutrients such as nitrogen and phosphorus. The …

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Differential Plant Invasiveness Is Not Always Driven By Host Promiscuity With Bacterial Symbionts, Metha M. Klock, Luke G. Barrett, Peter H. Thrall, Kyle E. Harms Jan 2016

Differential Plant Invasiveness Is Not Always Driven By Host Promiscuity With Bacterial Symbionts, Metha M. Klock, Luke G. Barrett, Peter H. Thrall, Kyle E. Harms

Faculty Publications

© The Authors 2016. Identification of mechanisms that allow some species to outcompete others is a fundamental goal in ecology and invasive species management. One useful approach is to examine congeners varying in invasiveness in a comparative framework across native and invaded ranges. Acacia species have been widely introduced outside their native range of Australia, and a subset of these species have become invasive in multiple parts of the world. Within specific regions, the invasive status of these species varies. Our study examined whether a key mechanism in the life history of Acacia species, the legume-rhizobia symbiosis, influences acacia invasiveness …

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Differential Roles Of Two Homologous Cyclin-Dependent Kinase Inhibitor Genes In Regulating Cell Cycle And Innate Immunity In Arabidopsis1[Open], Safae Hamdoun, Chong Zhang, Manroop Gill, Narender Kumar, Michelle Churchman, John C. Larkin, Ashley Kwon, Hua Lu Jan 2016

Differential Roles Of Two Homologous Cyclin-Dependent Kinase Inhibitor Genes In Regulating Cell Cycle And Innate Immunity In Arabidopsis1[Open], Safae Hamdoun, Chong Zhang, Manroop Gill, Narender Kumar, Michelle Churchman, John C. Larkin, Ashley Kwon, Hua Lu

Faculty Publications

© 2016 American Society of Plant Biologists. All Rights Reserved. Precise cell-cycle control is critical for plant development and responses to pathogen invasion. Two homologous cyclindependent kinase inhibitor genes, SIAMESE (SIM) and SIM-RELATED 1 (SMR1), were recently shown to regulate Arabidopsis (Arabidopsis thaliana) defense based on phenotypes conferred by a sim smr1 double mutant. However, whether these two genes play differential roles in cell-cycle and defense control is unknown. In this report, we show that while acting synergistically to promote endoreplication, SIM and SMR1 play different roles in affecting the ploidy of trichome and leaf cells, respectively. In addition, we …

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Two New Species Of Siphocampylus (Campanulaceae, Lobelioideae) From The Central Andes, Laura P. Lagomarsino, Daniel Santamaría-Aguilar Jan 2016

Two New Species Of Siphocampylus (Campanulaceae, Lobelioideae) From The Central Andes, Laura P. Lagomarsino, Daniel Santamaría-Aguilar

Faculty Publications

© L.P. Lagomarsino, D. Santamaría-Aguilar. Two species of Siphocampylus (Campanulaceae: Lobelioideae) from the Central Andes of Peru and Bolivia are described, illustrated, and discussed with reference to related species. One species, Siphocampylus antonellii, is endemic to high elevation grasslands of Calca, Peru, while the second, S. siberiensis, is endemic to cloud forests of Cochabamba, Bolivia. Both species are robust shrubs that produce tubular pink flowers that are likely pollinated by hummingbirds.

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African Fire Cultures, Cattle Ranching, And Colonial Landscape Transformations In The Neo-Tropics, Andrew Sluyter, Chris S. Duvall Jan 2016

African Fire Cultures, Cattle Ranching, And Colonial Landscape Transformations In The Neo-Tropics, Andrew Sluyter, Chris S. Duvall

Faculty Publications

No abstract provided.

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Syntheses And Cellular Investigations Of Di-Aspartate And Aspartate-Lysine Chlorin E6 Conjugates, R. G.Waruna Jinadasa, Zehua Zhou, M. Graça H. Vicente, Kevin M. Smith Jan 2016

Syntheses And Cellular Investigations Of Di-Aspartate And Aspartate-Lysine Chlorin E6 Conjugates, R. G.Waruna Jinadasa, Zehua Zhou, M. Graça H. Vicente, Kevin M. Smith

Faculty Publications

© The Royal Society of Chemistry 2016. Chlorin e6 is a tricarboxylic acid degradation product of chlorophyll a. Four chlorin e6 bis(amino acid) conjugates were regioselectively synthesized bearing two aspartate conjugates in the 131,173- and 152,173-positions, or at the 131,152via an ethylene diamine linker. One additional conjugate bearing two different amino acids, lysine at 131via an ethylene diamine linker and an aspartate at 152via a β-alanine linker was also synthesized. The cytotoxicity and uptake of four di(amino acid) chlorin e6 conjugates were investigated in human HEp2 cells, and compared with chlorin e6. The most cytotoxic and most taken up conjugates …

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Synthesis And Regioselective Functionalization Of Perhalogenated Bodipys, Ning Zhao, Sunting Xuan, Brandon Byrd, Frank R. Fronczek, Kevin M. Smith, M. Graça H. Vicente Jan 2016

Synthesis And Regioselective Functionalization Of Perhalogenated Bodipys, Ning Zhao, Sunting Xuan, Brandon Byrd, Frank R. Fronczek, Kevin M. Smith, M. Graça H. Vicente

Faculty Publications

© The Royal Society of Chemistry. Three perhalogenated BODIPYs (1b-3b), bearing chloro and bromo groups at all carbon positions, were synthesized and characterized. The reactivity of BODIPY 3b was investigated under Stille cross-coupling reactions, and single crystal X-ray analysis was used to confirm the regioselectivity of the reactions. Further substitution at the boron atom produced nona-functionalized BODIPYs 7a,b, which show 676 and 739 nm emissions with 91 and 100 nm Stokes shifts, respectively.

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Rletters: A Web-Based Application For Text Analysis Of Journal Articles, Charles H. Pence Jan 2016

Rletters: A Web-Based Application For Text Analysis Of Journal Articles, Charles H. Pence

Faculty Publications

While textual analysis of the journal literature is a burgeoning field, there is still a profound lack of user-friendly software for accomplishing this task. RLetters is a free, open-source web application which provides researchers with an environment in which they can select sets of journal articles and analyze them with cutting-edge textual analysis tools. RLetters allows users without prior expertise in textual analysis to analyze word frequency, collocations, cooccurrences, term networks, and more. It is implemented in Ruby and scripts are provided to automate deployment.

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Is Genetic Drift A Force?, Charles H. Pence Jan 2016

Is Genetic Drift A Force?, Charles H. Pence

Faculty Publications

One hotly debated philosophical question in the analysis of evolutionary theory concerns whether or not evolution and the various factors which constitute it (selection, drift, mutation, and so on) may profitably be considered as analogous to “forces” in the traditional, Newtonian sense. Several compelling arguments assert that the force picture is incoherent, due to the peculiar nature of genetic drift. I consider two of those arguments here—that drift lacks a predictable direction, and that drift is constitutive of evolutionary systems—and show that they both fail to demonstrate that a view of genetic drift as a force is untenable. I go …

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Modulation Of Il-27 In Adipocytes During Inflammatory Stress, Heesun Nam, Bradley S. Ferguson, Jacqueline M. Stephens, Ron F. Morrison Jan 2016

Modulation Of Il-27 In Adipocytes During Inflammatory Stress, Heesun Nam, Bradley S. Ferguson, Jacqueline M. Stephens, Ron F. Morrison

Faculty Publications

© 2015 The Obesity Society. Objective While it is well established that adipose tissue-derived inflammation plays an important role in the pathogenic mechanisms linking obesity with metabolic dysfunction, the inflammatory mediators involved have not been fully elucidated. Here, we explored IL-12 family cytokines with a focus on IL-27 during obesity-induced inflammation in mice and cultured adipocytes (ADs) following exposure to inflammatory stimuli. Methods Relative mRNA abundance of IL-12 cytokines was assessed by reverse transcription polymerase chain reaction (RT-PCR) in genetically obese B6-ob/ob mice as well as C57BL/6J mice fed a high-fat diet and in ADs following exposure to inflammatory stimuli. …

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Abstract Book: Papers And Posters, Conference Of Latin Americanist Geographers, New Orleans, January 3-5, 2017, Andrew Sluyter Jan 2016

Abstract Book: Papers And Posters, Conference Of Latin Americanist Geographers, New Orleans, January 3-5, 2017, Andrew Sluyter

Faculty Publications

No abstract provided.

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Biology And Management Of The Mexican Rice Borer (Lepidoptera: Crambidae) In Rice In The United States, J. M. Beuzelin, B. E. Wilson, M. T. Vanweelden, A. Mészáros, M. O. Way, M. J. Stout, T. E. Reagan Jan 2016

Biology And Management Of The Mexican Rice Borer (Lepidoptera: Crambidae) In Rice In The United States, J. M. Beuzelin, B. E. Wilson, M. T. Vanweelden, A. Mészáros, M. O. Way, M. J. Stout, T. E. Reagan

Faculty Publications

© The Author, 2016. The Mexican rice borer, Eoreuma loftini (Dyar), is an invasive pest of rice, Oryza sativa L., in the Gulf Coast region of the United States. This pest also damages sugarcane, Saccharum spp. hybrids; corn, Zea mays L.; and sorghum, Sorghum bicolor (L.) Moench, and feeds on weedy noncrop grasses. Multiple aspects of integrated pest management including use of pheromone traps, manipulation of planting dates, harvest cutting height, stubble management, noncrop host management, soil fertility management, host plant resistance, use of insecticides, and biological control have been studied for Mexican rice borer management. However, the current management …

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Obesity Impairs Skeletal Muscle Regeneration Through Inhibition Of Ampk, Xing Fu, Meijun Zhu, Shuming Zhang, Marc Foretz, Benoit Viollet, Min Du Jan 2016

Obesity Impairs Skeletal Muscle Regeneration Through Inhibition Of Ampk, Xing Fu, Meijun Zhu, Shuming Zhang, Marc Foretz, Benoit Viollet, Min Du

Faculty Publications

© 2016 by the American Diabetes Association. Obesity is increasing rapidly worldwide and is accompanied by many complications, including impaired muscle regeneration. The obese condition is known to inhibit AMPK activity in multiple tissues. We hypothesized that the loss of AMPK activity is a major reason for hampered muscle regeneration in obese subjects. We found that obesity inhibits AMPK activity in regenerating muscle, which was associated with impeded satellite cell activation and impaired muscle regeneration. To test the mediatory role of AMPKα1, we knocked out AMPKα1 and found that both proliferation and differentiation of satellite cells are reduced after injury …

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Deletion Of A Predicted Β-Sheet Domain Within The Amino Terminus Of Herpes Simplex Virus Glycoprotein K Conserved Among Alphaherpesviruses Prevents Virus Entry Into Neuronal Axons, Nithya Jambunathan, Anu Susan Charles, Ramesh Subramanian, Ahmad A. Saied, Misagh Naderi, Paul Rider, Michal Brylinski, Vladimir N. Chouljenko, Konstantin G. Kousoulas Jan 2016

Deletion Of A Predicted Β-Sheet Domain Within The Amino Terminus Of Herpes Simplex Virus Glycoprotein K Conserved Among Alphaherpesviruses Prevents Virus Entry Into Neuronal Axons, Nithya Jambunathan, Anu Susan Charles, Ramesh Subramanian, Ahmad A. Saied, Misagh Naderi, Paul Rider, Michal Brylinski, Vladimir N. Chouljenko, Konstantin G. Kousoulas

Faculty Publications

© 2016, American Society for Microbiology. We have shown previously that herpes simplex virus 1 (HSV-1) lacking expression of the entire glycoprotein K (gK) or expressing gK with a 38-amino-acid deletion (gKΔ31-68 mutation) failed to infect ganglionic neurons after ocular infection of mice. We constructed a new model for the predicted three-dimensional structure of gK, revealing that the gKΔ31-68 mutation spans a well-defined β-sheet structure within the amino terminus of gK, which is conserved among alphaherpesviruses. The HSV- 1(McKrae) gKΔ31-68 virus was tested for the ability to enter into ganglionic neuronal axons in cell culture of explanted rat ganglia using …

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Herpes Simplex Virus 1 Ul37 Protein Tyrosine Residues Conserved Among All Alphaherpesviruses Are Required For Interactions With Glycoprotein K, Cytoplasmic Virion Envelopment, And Infectious Virus Production, Dmitry V. Chouljenko, Nithya Jambunathan, Vladimir N. Chouljenko, Misagh Naderi, Michal Brylinski, John R. Caskey, Konstantin G. Kousoulas Jan 2016

Herpes Simplex Virus 1 Ul37 Protein Tyrosine Residues Conserved Among All Alphaherpesviruses Are Required For Interactions With Glycoprotein K, Cytoplasmic Virion Envelopment, And Infectious Virus Production, Dmitry V. Chouljenko, Nithya Jambunathan, Vladimir N. Chouljenko, Misagh Naderi, Michal Brylinski, John R. Caskey, Konstantin G. Kousoulas

Faculty Publications

© 2016, American Society for Microbiology. All Rights Reserved. The herpes simplex virus 1 (HSV-1) UL37 protein functions in virion envelopment at trans-Golgi membranes, as well as in retrograde and anterograde transport of virion capsids. Recently, we reported that UL37 interacts with glycoprotein K (gK) and its interacting partner protein UL20 (N. Jambunathan, D. Chouljenko, P. Desai, A. S. Charles, R. Subramanian, V. N. Chouljenko, and K. G. Kousoulas, J Virol 88:5927-5935, 2014, http://dx.doi.org/10.1128/JVI.00278-14), facilitating cytoplasmic virion envelopment. Alignment of UL37 homologs encoded by alphaherpesviruses revealed the presence of highly conserved residues in the central portion of the UL37 protein. …

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Deletion Of A Predicted Β-Sheet Domain Within The Amino Terminus Of Herpes Simplex Virus Glycoprotein K Conserved Among Alphaherpesviruses Prevents Virus Entry Into Neuronal Axons, Nithya Jambunathan, Anu Susan Charles, Ramesh Subramanian, Ahmad A. Saied, Misagh Naderi, Paul Rider, Michal Brylinski, Vladimir N. Chouljenko, Konstantin G. Kousoulas Jan 2016

Deletion Of A Predicted Β-Sheet Domain Within The Amino Terminus Of Herpes Simplex Virus Glycoprotein K Conserved Among Alphaherpesviruses Prevents Virus Entry Into Neuronal Axons, Nithya Jambunathan, Anu Susan Charles, Ramesh Subramanian, Ahmad A. Saied, Misagh Naderi, Paul Rider, Michal Brylinski, Vladimir N. Chouljenko, Konstantin G. Kousoulas

Faculty Publications

© 2016, American Society for Microbiology. We have shown previously that herpes simplex virus 1 (HSV-1) lacking expression of the entire glycoprotein K (gK) or expressing gK with a 38-amino-acid deletion (gKΔ31-68 mutation) failed to infect ganglionic neurons after ocular infection of mice. We constructed a new model for the predicted three-dimensional structure of gK, revealing that the gKΔ31-68 mutation spans a well-defined β-sheet structure within the amino terminus of gK, which is conserved among alphaherpesviruses. The HSV- 1(McKrae) gKΔ31-68 virus was tested for the ability to enter into ganglionic neuronal axons in cell culture of explanted rat ganglia using …

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