Digital Commons Network^™

Predicting Drug Sensitivity Of Cancer Cells Based On Dna Methylation Levels, Sofia P. Miranda, Fernanda A. Baião, Julia L. Fleck, Stephen R. Piccolo

Faculty Publications

Cancer cell lines, which are cell cultures derived from tumor samples, represent one of the least expensive and most studied preclinical models for drug development. Accurately predicting drug responses for a given cell line based on molecular features may help to optimize drug-development pipelines and explain mechanisms behind treatment responses. In this study, we focus on DNA methylation profiles as one type of molecular feature that is known to drive tumorigenesis and modulate treatment responses. Using genome-wide, DNA methylation profiles from 987 cell lines in the Genomics of Drug Sensitivity in Cancer database, we used machine-learning algorithms to evaluate the …

Dreams Interrupted: A Mixed-Methods Research Project Exploring Latino College Completion, Kate Sablosky Elengold, Jess Dorrance, Amanda Martinez, Patricia Foxen, Paul Mihas

Faculty Publications

Latino students are entering college at record numbers; Today, almost 3.8 million Latinos are enrolled in colleges and universities across the United States. Yet Latino students trail their White and Asian peers in attaining college degrees. The overall completion gap exceeds ten percentage points.

Although scholars and advocates have pointed to several different barriers facing Latino college students, a persistent narrative focuses on Latino students’ aversion to taking on student debt. In response, researchers at the University of North Carolina-Chapel Hill and UnidosUS undertook a multi-year mixed-method study to test and interrogate whether and how debt aversion affects Latino college …

Concurrent Associations Between Expressive Language Ability And Independence In Adolescents And Adults With Fragile X Syndrome, Leonard Abbeduto, Jessica Klusek, Julie Lounds Taylor, Nadia Abdelnur, Nicole Sparapani, Angela John Thurman

Faculty Publications

BACKGROUND: Few individuals with fragile X syndrome (FXS) successfully meet adult normative expectations in education, employment, peer relations, and habitation, although there is within-syndrome variability in this regard. The primary goal of this study was to determine whether expressive language skills contribute to the capacity for independent functioning in adulthood even after controlling for nonverbal cognitive ability. METHODS: Participants were 18- to 23-year-olds with FXS. Expressive language was assessed using the psychometrically validated Expressive Language Sampling (ELS) conversation and narration procedures. The language produced was transcribed and analyzed to yield measures of expressive vocabulary, syntax, and intelligibility. Parents concurrently completed …

The Power Of Tolerance Vs. Unselfishness As A Cultural Determinant Of Cooperation, Kimmo Eriksson, Brent Simpson, Irina Vartanova

Faculty Publications

Cooperation in collective action problems and resource dilemmas is often assumed to depend on the values of the individuals involved, such as their degree of unselfishness and tolerance. Societal differences in cooperation and cooperative norms may therefore result from cultural variation in emphasis on these personal values. Here we draw on several cross-national datasets to examine whether society-level emphasis on unselfishness and tolerance and respect for other people predict how societies vary in cooperation [in a continuous prisoner’s dilemma (PD)] and in norms governing cooperation [in a common pool resource dilemma (CPR)]. The results suggest that high levels of cooperation …

Relationship Between Food Insecurity And Smoking Status Among Women Living With And At Risk For Hiv In The Usa: A Cohort Study, Lila A. Sheira, Edward A. Frongillo Jr., Judith Hahn, Kartika Palar, Elise D. Riley, Tracey E. Wilson, Adebola Adedimeji, Daniel Merenstein, Mardge Cohen, Eryka L. Wentz, Adaora A. Adimora, Ighovwerha Ofotokun, Lisa Metsch, Janet M. Turan, Phyllis C. Tien, Sheri D. Weiser

Faculty Publications

Objectives People living with HIV (PLHIV) in the USA, particularly women, have a higher prevalence of food insecurity than the general population. Cigarette smoking among PLHIV is common (42%), and PLHIV are 6–13 times more likely to die from lung cancer than AIDS related causes. This study sought to investigate the associations between food security status and smoking status and severity among a cohort of predominantly low-income women of colour living with and without HIV in the USA.

Design Women enrolled in an ongoing longitudinal cohort study from 2013 to 2015.

Setting Nine participating sites across the USA.

Participants 2553 …

A Dichotomy Of Sport Sponsorships: Does The Nature Of Competition Among Sponsors Matter?, Thomas Doellman, Brian Walkup, Adrien Bouchet, Brian Chabowski

Faculty Publications

In this paper, we argue that the firm value implications of sport sponsorships for sponsors may depend on the competitive environment during the bidding process for different types of sponsorships. More specifically, we contend that the bidding environment for professional football (soccer) kit sponsorships represents a form of common value auction, while the bidding environment for corporate logo sponsorships on teams’ shirts does not. As common value auctions are prone to winner’s curse, the firm value implications should be different for kit sponsorship announcements than for shirt sponsorship announcements. Our results suggest that shareholders indeed perceive the value derived from …

Examining Associations Between Knowledge And Vaccine Uptake Using The Human Papillomavirus Knowledge Questionnaire (Hpv-Kq), Sayward Harrison, Valerie Yelverton, Yunfei Wang, Jan Ostermann, Laura J. Fish, Charnetta L. Williams, Lavanya Vasudevan, Emmanuel B. Walter

Faculty Publications

Objectives: Understanding the relationship between human papillomavirus (HPV) knowledge and vaccination behavior is important to inform public health interventions, yet few validated HPV knowledge scales exist. This study describes development of the Human Papillomavirus Knowledge Questionnaire (HPV-KQ) and its validation with parents residing in the southern United States (US). Methods: Drawing on previously published measures, we developed the 13-item HPV-KQ and administered the scale via Web-based survey to parents (N=1105) of adolescents ages 9 to 17 years. Dimensionality, internal consistency, model fit, and predictive validity were assessed. Results: The scale was bidimensional. One factor captured general HPV knowledge, and the …

Examining Associations Between Knowledge And Vaccine Uptake Using The Human Papillomavirus Knowledge Questionnaire (Hpv-Kq), Sayward Harrison, Valerie Yelverton, Jan Ostermann Ph.D., Laura J. Fish, Charnetta L. Williams, Lavanya Vasudevan, Emmanuel B. Walter

Faculty Publications

Objectives: Understanding the relationship between human papillomavirus (HPV) knowledge and vaccination behavior is important to inform public health interventions, yet few validated HPV knowledge scales exist. This study describes development of the Human Papillomavirus Knowledge Questionnaire (HPV-KQ) and its validation with parents residing in the southern United States (US). Methods: Drawing on previously published measures, we developed the 13-item HPV-KQ and administered the scale via Web-based survey to parents (N=1105) of adolescents ages 9 to 17 years. Dimensionality, internal consistency, model fit, and predictive validity were assessed. Results: The scale was bidimensional. One factor captured general HPV knowledge, and the …

An Extended Essay On Church Autonomy, Carl H. Esbeck

Faculty Publications

The doctrine of church autonomy has its own exclusive line of precedent running from Watson v. Jones (1872) through Kedroff v. St. Nicholas Cathedral (1952) - where the doctrine was first recognized as having First Amendment stature - and culminating with renewed vigor for religious institutional autonomy in the unanimous decision of Hosanna-Tabor Evangelical Lutheran Church and School v. EEOC (2012). Attention to church autonomy has expanded rapidly since the Supreme Court’s decision in Hosanna-Tabor, and its scope is much disputed as it pushes aside other claims and interests. In its most familiar form—the “ministerial exception” - it is …

Trapping Soybean Looper (Lepidoptera: Noctuidae) In The Southeastern Usa And Implications For Pheromone-Based Research And Management, Daniel E. Fleming, Jeffrey A. Davis, Fred R. Musser, Silvana V. Paula-Moraes, Ronald C. Stephenson, Christopher A. Wheeler, Earl Eugene Ringpis, Tyler S. Crum, J. Khai Tran

Faculty Publications

Novel strategies for the management of soybean looper, Chrysodeixis includens (Walker) (Lepidoptera: Noctuidae), are needed due to its increasing importance, costs, and challenges of management in soybeans (Glycine max [L.] Merr.; Fabaceae) in the Americas. Pheromone-mediated mating disruption may be 1 such novel strategy, but an effective tool for estimating mating disruption success must be found. The technique of trapping male moths using pheromone baited traps is a common method for assessing mating disruption technology. This paper reports on the testing of 2 trap types and 3 commercially available lures containing (Z)-7-dodecenyl acetate as the major active component. Trapping was …

Temporal Changes In Cuticular Hydrocarbons During Worker-Reproductive Transition In The Eastern Subterranean Termite (Blattodea: Rhinotermitidae), Qian Sun, Kenneth F. Haynes, Xuguo Zhou

Faculty Publications

In social insects, the reproductive division of labor is often regulated through communication using cuticular hydrocarbons (CHCs) that indicate caste identity and reproductive status. In many termites, workers retain reproductive potential and can differentiate into ergatoid reproductives, and this process is mediated by the presence of reproductives in sex- and age-specific patterns. However, little is known about the variation of CHCs profiles during this transition. In this study, we analyzed the CHC profiles of workers in comparison with ergatoids of different age, sex, and mating status in the eastern subterranean termite, Reticulitermes flavipes (Kollar) (Blattodea: Rhinotermitidae), one of the most …

Managing Corpses From Different Castes In The Eastern Subterranean Termite, Jizhe Shi, Chi Zhang, Sirui Huang, Austin Merchant, Qian Sun, Chuan Zhou, Kenneth F. Haynes, Xuguo Zhou

Faculty Publications

Corpse management is essential for social animals to maintain colony health. In the eastern subterranean termite, Reticulitermes flavipes, workers carry out undertaking behaviors to mitigate the risks associated with the dead. In this study, we hypothesized that termites would respond differently to the corpses from different castes based on their postmortem chemical signatures. To test this hypothesis, we 1) documented the behavioral responses of the workers toward corpses from different castes, and 2) profile the chemical signatures of these corpses. Corpses from all castes were retrieved inside the nests and cannibalized when they were decomposed <64 >h, regardless of the presence …

Biology, Ecology, And Pest Management Of The Tarnished Plant Bug, Lygus Lineolaris (Palisot De Beauvois) In Southern Row Crops, Justin George, James P. Glover, Jeffrey Gore, Whitney D. Crow, Gadi V.P. Reddy

Faculty Publications

The tarnished plant bug, Lygus lineolaris (Palisot de Beauvois), (Hemiptera: Miridae) is considered the most damaging pest of cotton (Gossypium hirsutum L.) in the mid-southern United States, although it is established throughout the United States, southern Canada, and northern Mexico. The introduction of transgenic crops for the control of moths in the Heliothine complex and eradication of the boll weevil, Anthonomus grandis, from much of the United States led to greatly reduced pesticide use in cotton fields, which allowed L. lineolaris to emerge as a new primary pest of cotton in the mid-southern United States. Since the publication of a …

A 3d Printed Vitrification Device For Storage In Cryopreservation Vials, Yue Liu, Andy Lin, Terrence R. Tiersch, William Todd Monroe

Faculty Publications

Sperm cryopreservation by vitrification is a promising approach for small-bodied animals such as zebrafish (Danio rerio). However, most vitrification tools adopted in aquatic research were initially designed for applications other than sperm (such as human embryo freezing) and, thus, pose challenges for adoption to sperm vitrification. Three-dimensional (3D) printing combined with open hardware sharing is an emerging strategy to address challenges in the development of cryo-preservation tools. The goal of this study was to develop a 3D printed Vitrification Device for Cryo-Vials (VDCV) that can be integrated with the existing vial storage systems. The VDCV combined the vitrification and handling …

A Baker's Dozen Of Top Antimicrobial Stewardship Intervention Publications In 2020, Sarah B. Green, Kayla R. Stover, Katie Barber, Jeannette L. Bouchard, Matthew L. Brown, Connor R. Deri, Bailey J. Francis, Timothy P. Gauthier, Jillian E. Hayes, Ashley H. Marx, Edoabasi U. Mcgee, Krutika Mediwala, Rachel J. Musgrove, Douglas Slain, Stefanie A. Stramel, Christopher M. Bland, P Brandon Bookstaver

Faculty Publications

The number of articles related to antimicrobial stewardship published each year has increased significantly over the last decade. Keeping up with the literature, particularly the most innovative, well-designed, or applicable to one's own practice area, can be challenging. The Southeastern Research Group Endeavor (SERGE-45) network reviewed antimicrobial stewardship-related, peer-reviewed literature from 2020 that detailed actionable interventions. The top 13 publications were summarized following identification using a modified Delphi technique. This article highlights the selected interventions and may serve as a key resource for teaching and training, and to identify novel or optimized stewardship opportunities within one's institution.

A Dose Of Dignity : Equitable Vaccination Policies For Incarcerated People And Correctional Staff During The Covid-19 Pandemic, Itay Ravid, Jordan M. Hyatt, Steven L. Chanenson

Faculty Publications

Since its emergence in early 2020, the COVID-19 pandemic has altered the lives of millions of Americans. As it so often is during times of crisis, our most vulnerable communities have disproportionately suffered and were overlooked. Among these myriad communities, incarcerated people became a particularly potent symbol of our failure to handle the spread of the virus. In December 2020, a beacon of hope emerged with the introduction of new cutting-edge vaccines which promised to bring the world back to where it was just a year-and-a-half ago. Here again, however, policy and politics have led states to adopt different distribution …

Family Resilience: Being Refined By The Fire, Alina M. Baltazar

Faculty Publications

No abstract provided.

Including Latinx Communities In Academic Libraries: A Theoretical Approach To Information Access, Andrew Wakelee, Kim M. Thompson

Faculty Publications

While more Latinx students continue to enroll in higher education, physical, intellectual, and socio-cultural barriers to information may continue to impede their success and inclusion. A tripartite theoretical model that examines physical, intellectual, and socio-cultural information access provides insights for academic libraries to better meet Latinx students’ information needs and include them in campus life. This paper gives an overview of the theoretical framework along with practical steps libraries can take to improve information equity.

Prevalence, Awareness, And Control Of Hypertension Among Bangladeshi Adults: An Analysis Of Demographic And Health Survey 2017-18, Gulam Muhammed Al Kibria, Rajat Das Gupta Ph.D., Jannatun Nayeem

Faculty Publications

Background

The prevalence of hypertension is increasing in Bangladesh, however, few recent studies investigated the proportion of people and factors associated with prevalence, awareness, and control of this condition in this country. This study investigated these among Bangladeshi adults.

Methods

Using Bangladesh Demographic and Health Survey 2017–18 data, a cross-sectional study was conducted. Multilevel logistic regression analysis was employed after descriptive analysis and prevalence estimation.

Results

Among 12,926 persons (mean age: 40 years, 57% women), the prevalence of hypertension was 27.4% (n = 3551), it was 28.4 and 26.2% among females and males, respectively. Among hypertensive people, about 42.4% …

Vacuum Infusion Of Composites: Durability Of Hybrid Large Area Additive Tooling For Vacuum Infusion Of Composites, Nathan Northrup, Jason Weaver, Andy R. George

Faculty Publications

The durability of a hybrid large area additively manufactured fiberglass ABS mold for vacuum infusion of composites was evaluated. The validation was done by designing and fabricating a mold for a custom test artifact and analyzing the surface geometry over the course of multiple infusions until tool failure. After printing and machining, the mold required a sealer to maintain vacuum integrity. The mold was able to produce 10 parts successfully before the sealed tool surface began to tangibly roughen, resulting in increased difficulty of demolding and a rougher surface finish. After the 14th infusion, the part required destructive force to …

Organizational Learning During Covid-19: A Qualitative Study Of Nurses' Experiences, Bret Lyman, Morgan K. Horton, Alyssa Oman

Faculty Publications

Aim: The aim of this study is to test the validity of the Organizational Learning in Hospitals model in the context of the COVID-19 pandemic.

Background: Organizational learning is especially crucial in circumstances of intense, complex, enduring change, as with the COVID-19 pandemic. Nurse managers need additional guidance for fostering organizational learning under such circumstances. The Organizational Learning in Hospitals model may be a helpful resource but requires additional validation.

Methods: Semi-structured interviews were conducted to gather 19 nurses' first-hand experiences of organizational learning during the COVID-19 pandemic. Data were analysed using deductive thematic analysis.

Results: Nurses' experiences of organizational …

Setting The Research Agenda For Nursing Administration And Leadership Science: A Delphi Study, Esther Maria Chipps, M Lindell Joseph, Catherine Alexander, Bret Lyman, Logan Mcginty, Heather Nelson-Brantley, Joy Parchment, Reynaldo R. Rivera, Mary Anne Schultz, Danielle M. Ward, Susan Weaver

Faculty Publications

Objective: The aim of this study was to identify and prioritize research topics for nursing administration and leadership science.

Background: Nursing administration and leadership research priorities should provide a framework for building the science needed to inform practice.

Methods: The Association for Leadership Science in Nursing (ALSN) and American Organization for Nursing Leadership (AONL) Foundation (AONL-F) for Nursing Leadership and Education collaborated on a Delphi study. Initial input on research priority items were received from ALSN and AONL members. National experts participated in a 3-round Delphi study.

Results: Top-ranked priorities included: 1) nurses' health, well-being, resiliency, and safety in the …

Honoring The Mother Of All People; Contemporary Indigenous Leadership In Revitalizing Environmental And Cultural Sustainability, Katharine A. Duderstadt, Alexandra G. Martin, Svetlana Peshkova, Siobhan Senier, Jennifer F. Brewer, Daniel R. Howard

Faculty Publications

This series of events brings Indigenous perspectives from 22 Indigenous speakers across the U.S. and Arctic regions to discussions of sustainable futures within the New Hampshire community. There is growing movement in the academic community to understand how Indigenous knowledge and cultural heritage can deepen our thinking about sustainable futures. While most researchers recognize that anthropogenic climate change and other sustainability challenges require humanistic as well as scientific approaches, many have yet to thoroughly understand the colonial legacies that initiated many of these sustainability problems and continue to impede our study and solutions. The 2020-2021 Sidore Series was designed to …

Ocean Regime Shift Is Driving Collapse Of The North Atlantic Right Whale Population, Erin L. Meyer-Gutbrod, Charles H. Greene, Kimberley T.A. Davies, David G. Johns

Faculty Publications

Ocean warming linked to anthropogenic climate change is impacting the ecology of marine species around the world. In 2010, the Gulf of Maine and Scotian Shelf regions of the Northwest Atlantic underwent an unprecedented regime shift. Forced by climate-driven changes in the Gulf Stream, warm slope waters entered the region and created a less favorable foraging environment for the endangered North Atlantic right whale population. By mid-decade, right whales had shifted their late spring/summer foraging grounds from the Gulf of Maine and the western Scotian Shelf to the Gulf of St. Lawrence. The population also began exhibiting unusually high …

James White Library Digital Initiatives, Margaret Adeogun

Faculty Publications

No abstract provided.

Assessing Oral Language When Screening Multilingual Children For Learning Disabilities In Reading, J. Marc Goodrich, Lisa A. Fitton Ph.D., Jessica Chan, C. Jamie Davis

Faculty Publications

Multilingual children represent a rapidly growing population of students in U.S. schools. However, identification of language and learning disabilities for students from different linguistic backgrounds is complex, leading to frequent misidentification of multilingual learners for special education. This article provides guidance on how special education teachers, speech-language pathologists, and other practitioners (e.g., school psychologists) can utilize each other’s expertise to accurately assess language and literacy skills of multilingual learners. Five key lessons learned from research on identification of language disorders are presented, along with discussion of why these are important when screening multilingual children for learning disabilities in reading. Specifically, …

Relationship Form And Function: Exploring Meaning-Making In Young Adults' Romantic Histories, Tyler B. Jamison, Caroline M. Sanner

Faculty Publications

Forming stable, supportive romantic relationships is an important determinant of well-being for adults. Yet, there has been limited research about if and how prior romantic experiences help individuals develop the capacity to enter into such unions. Using grounded theory methods, relationship history interviews were conducted with 35 young adults who provided data about 256 romantic and sexual relationships. The different relationship forms (e.g., hooking up, casual dating, committed partnering) were found to contribute in nuanced ways to romantic development. Specifically, romantic development was characterized by gaining romantic experience, identifying preferences for partners and partnership, and learning to maintain healthy relational …

‘Access Necessitates Being Seen’: Queer Visibility And Intersectional Embodiment Within The Health Information Practices Of Queer Community Leaders, Travis L. Wagner, Vanessa Kitzie

Faculty Publications

Navigating healthcare infrastructures is particularly challenging for queer-identifying individuals, with significant barriers emerging around stigma and practitioner ignorance. Further intersecting, historically marginalised identities such as one’s race, age or ability exacerbate such engagement with healthcare, particularly the access to and use of reliable and appropriate health information. We explore the salience of one’s queer identity relative to other embodied identities when navigating health information and care for themselves and their communities. Thirty semi-structured interviews with queer community leaders from South Carolina inform our discussion of the role one’s queer visibility plays relational to the visibility of other identities. We find …

Encirclement Of Moving Targets Using Noisy Range And Bearing Measurements, Cammy Peterson, Puneet Jain, Randal Beard

Faculty Publications

This paper presents theoretically justified controllers that use relative range and bearing measurements to steer a team of autonomous vehicles, operating without inertial position information, to circular trajectories around a constant-acceleration, constant-velocity, or stationary target. An extended Kalman filter is used to improve the noisy relative measurements and estimate the velocity of the moving target. These estimated values are used in the control laws to encircle constant-velocity moving targets. Lyapunov techniques are utilized to show that the vehicle will converge to the desired circular formations. Additionally, cooperating vehicles are shown to converge to a circular formation with equal temporal spacing …

Re-Visiting Acoustic Sounding To Advance The Measurement Of Optical Turbulence, Steven T. Fiorino, Santasri Bose-Pillai, Kevin J. Keefer

Faculty Publications

Optical turbulence, as determined by the widely accepted practice of profiling the temperature structure constant, C²_T, via the measurement of ambient atmospheric temperature gradients, can be found to differ quite significantly when characterizing such gradients via thermal-couple differential temperature sensors as compared to doing so with acoustic probes such as those commonly used in sonic anemometry. Similar inconsistencies are observed when comparing optical turbulence strength derived via C²_T as compared to those through direct optical or imaging measurements of small fluctuations of the index of refraction of air (i.e., scintillation). These irregularities are especially apparent …